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2021 Vol. 27, No. 7 Published: 2021-07-31 1057 Effects of Danbai Granule on TGF-β/Smad Signaling Pathway and Endometrial Fibrosis in Rats with Intrauterine Adhesions TAN Liping, et al DOI: 10.3969/j.issn.1006-6233.2021.07.001 Objective: To investigate the effect of Danbai Granule on endometrial fibrosis in rats with intrauterine adhesion (IUA) and its possible mechanism. Methods: SD rats were randomly divided into sham operation group (15 rats) and model group (65 rats), the IUA model was established by mechanical curettage and infective injury, and the sham operation only underwent laparotomy and uterine suture. The successful models were divided into model group, Danbai Granule low-dose group (2.5 g/kg), Danbai Granule middle-dose group (5.0 g/kg) and Danbai Granule high-dose group (10.0 g/kg), with 15 in each group. The drug was administered 24 hours after successful modeling, Danbai Granule low, medium and high dose groups was given by gavage according to the dosage, while the sham operation group and the model group were given the same amount of normal saline, the time of intragastric administration was from 7∶00 to 10∶00 a.m, continuous gavage for 24 days. At 24 hours after the last administration, the uterine tissues were collected, the uterine permeability and AFS score were measured, hematoxylin eosin staining (HE) was used to detect the pathological changes, endometrial thickness and the number of glands in each group. Masson staining was used to detect the degree of endometrial fibrosis; enzyme linked immunosorbent assay (ELISA) was used to detect the collagen content in rat uterus; and Western blot was used to detect the expression of transforming growth factor-β1 (TGF-β1)/Smad pathway protein in endometrium. Results: Compared with those in the sham operation group, the uterine cavity disappeared; the cavity wall tissue showed adhesion state, the endometrial thickness and the number of glands were significantly reduced in the model group; the uterine patency score, AFS score, content of insoluble collagen and area of endometrial fibrosis were significantly higher; the protein expression levels of TGF-β1 and Smad3 in endometrium were significantly higher, and the expression level of Smad7 protein were significantly lower (P<0.05); compared with those in the model group, the endometrial thickness and the number of glands in the Danbai Granule low, medium and high dose groups were higher to a certain extent, the patency of uterus and the degree of endometrial fibrosis were relieved, and the content of insoluble collagen was significantly lower; the protein expression levels of TGF-β1 and Smad3 showed an decreasing trend; the expression of Smad7 protein showed an increasing trend (P<0.05); there was a certain dose effect relationship. Conclusion: Danbai granule can effectively alleviate the degree of endometrial fibrosis in IUA rats, which may be related to the inhibition of TGF-β/Smad pathway. 2021 Vol. 27 (7): 1057-1062 [Abstract] ( 196 ) HTML (1 KB)  PDF (1616 KB)  ( 364 ) 1063 Role of Endogenous Relaxin-1 Relaxin-3 and Receptor LGR7 in Myocardial Fibrosis of Mice with Atrial Fibrillation WENG Fangzhong, HU Chaoliang, YAN Jun, et al DOI: 10.3969/j.issn.1006-6233.2021.07.002 Objective: To analyze the role of endogenous relaxin (RLX)-1, relaxin-3 and relaxin receptor (LGR7) in myocardial fibrosis of mice with atrial fibrillation. Methods: Atrial fibrillation model was constructed by intraperitoneal injection of ISO. 40 C57B62 mice were randomly divided into blank control group, model group, model group + RLX1 and model group + RLX3 group with 10 mice in each group. The model group + RLX1 and model group + RLX3 were intraperitoneally injected with RLX1 and RLX3, respectively. The blank control group and model group were injected with the same volume of normal saline. A week later, the area of myocardial collagen deposition and the content of hydroxyproline were detected. RT-PCR and Western Blot were used to detect the mRNA and protein expression of relaxin 1, relaxin 3 and LGR7. Immunohistochemical method was used to detect α-SMA integral optical density (IOD), and Western Blot was used to detect the expression of α-SMA protein in myocardial tissues. Real-time PCR and Western Blot were used to detect the mRNA and protein expression of collagenⅠ, collagen III, matrix metalloproteinase-1 (MMP-1), MMP-2, MMP-9, MMP-13, and tissue inhibitor of metalloproteinase-1 (TIMP-1). Meanwhile, RT-PCR method was used to detect the mRNA expression of myocardial angiotensin II (AngII), angiotensin receptor 1 (AT1R), angiotensin receptor 2 (AT2R), aldosterone (ALD) and mineralocorticoid receptor (MR). Results: ①Compared with the blank control group, the percentages of myocardial collagen deposition areas in ventricular septum, right ventricle and left ventricle, and the content of hydroxyproline were significantly increased in the model group (P<0.05). Compared with the model group, the percentages of myocardial collagen deposition areas in ventricular septum, right ventricle and left ventricle, and the content of hydroxyproline were significantly reduced in the model group+RLX1 and model group+RLX3 (P<0.05). ②Compared with the blank control group, the mRNA and protein expression of relaxin 1, relaxin 3 and LGR7 was significantly reduced in the model group (P<0.05). Compared with the model group, the mRNA and protein expression of relaxin 1, relaxin 3 and LGR7 was significantly increased in model group +RLX1 and model group+RLX3 (P<0.05). ③Compared with the blank control group, α-SMA IOD, α-SMA protein, the mRNA and protein expression of collagenⅠ and collagenⅢ were significantly increased in the model group (P<0.05). Compared with the model group, α-SMA IOD, α-SMA protein, the mRNA and protein expression of collagenⅠ and collagenⅢ were significantly reduced in the model group+RLX1 and the model group+RLX3 (P<0.05). ④Compared with the blank control group, the mRNA and protein expression of MMP-1, MMP-2, MMP-9 and MMP-13 was significantly increased, while the expression of TIMP-1 mRNA and protein was significantly reduced in the model group (P<0.05). Compared with the model group, the mRNA and protein expression of MMP-1, MMP-2, MMP-9 and MMP-13 was significantly decreased, while the expression of TIMP-1 mRNA and protein was significantly increased in the model group+RLX1 and model group+RLX3 (P<0.05). ⑤Compared with the blank control group, the levels of Ang Ⅱ mRNA, AT1R mRNA, AT2R mRNA, ALD mRNA, and MR mRNA were significantly increased in the model group. Compared with the model group, the levels of Ang Ⅱ mRNA, AT1R mRNA, AT2R mRNA, ALD mRNA, and MR mRNA were significantly reduced in the model group+RLX1 and model group+RLX3. Conclusion: The pathological changes of myocardial fibrosis are observed in the heart of the AF mice, and the endogenous relaxin-1, relaxin-3 and LGR7 are low expression, and relaxin could be antagonized by AngII and ALD system. 2021 Vol. 27 (7): 1063-1069 [Abstract] ( 139 ) HTML (1 KB)  PDF (1558 KB)  ( 213 ) 1070 Changes of Serum MBL Masp-2 and DKK-1 Levels in Patients with Rheumatoid Arthritis and Their Correlation with Prognosis ZANG Xuelian, JU Yanling, ZHAO Xu DOI: 10.3969/j.issn.1006-6233.2021.07.003 Objective: To study the changes of levels of serum mannose-binding lectin (MBL), MBL-associated serine protease-2 (MASP-2) and Dickkopf-1 protein (DKK-1) in patients with rheumatoid arthritis (RA) and their correlation with prognosis of patients. Methods: 194 RA patients and 102 health examiners in our hospital from August 2017 to August 2020 were selected as the study group and the control group. Serum MBL, masp-2 and DKK-1 levels were detected at admission. According to 28 joint disease activity scores (DAS28), the patients were divided into mild group (n = 83), moderate group (n = 62) and severe group (n = 49). According to the guidelines, RA patients were given standard treatment. According to the efficacy, the patients were divided into standard group (n = 129) and standard group (n = 65), The serum levels of MBL, masp-2 and DKK-1 were compared in each group, and their influence on DAS28 score and predictive value for curative effect were analyzed. Results: The levels of serum MBL and MASP-2 in study group were lower than those in control group, while the level of serum DKK-1 was higher than that in control group. The levels of serum MBL and MASP-2 in mild, moderate and severe groups were gradually decreased, while the level of serum DKK-1 and DAS28 score were gradually increased. The levels of serum MBL and MASP-2 in standard group were higher than those in non-standard group, while the level of serum DKK-1 was lower than that in non-standard group (P<0.05). Multivariate linear regression analysis showed that the levels of serum MBL and MASP-2 were important factors affecting the DAS28 score (P<0.05). Serum MBL and MASP-2 levels were closely related to the treatment effect of RA, and logistics regression model of substandard RA treatment was shown as Y=12.573-0.722× serum MBL-0.090× serum MASP-2+0.792× serum DKK-1. The AUC values of serum MBL, MASP-2, DKK-1 and the combined detection of the three in predicting the efficacy of RA were 0.896, 0.825, 0.693 and 0.958 respectively, and the sensitivities were 72.09%, 67.44%, 80.62% and 89.15%, and the specificities were 90.77%, 81.54%, 52.31% and 90.77%. Conclusion: The levels of MBL and masp-2 in serum of RA patients were significantly decreased, while the level of DKK-1 in serum was significantly increased, which was closely related to the changes of the disease, and could provide reference information for the evaluation of curative effect and prognosis. 2021 Vol. 27 (7): 1070-1075 [Abstract] ( 131 ) HTML (1 KB)  PDF (1388 KB)  ( 445 ) 1076 The Effect of Reduced Glutathione Combined with Polyene Phosphatidylcholine on CRP IL-6 PCT and Liver Function in Patients with Acute Drug-Induced Liver Injury LI Congying, YANG Zhanjiang, DU Guangqing DOI: 10.3969/j.issn.1006-6233.2021.07.004 Objective: To explore the effect of reduced glutathione combined with polyene phosphatidylcholine on CRP, IL-6, PCT and liver function in patients with acute drug-induced liver injury. Methods: The clinical data of 68 patients with acute drug-induced liver damage were selected for retrospective analysis from January 2018 to January 2020. According to different treatment drugs, they were divided into control group (treated with polyene phosphatidylcholine) and observation group (treated with reduced glutathione combined with polyene phosphatidylcholine), 34 cases in each group. The CRP, IL-6, PCT, TBIL, ALT, AST, GGT, TBA, MELD score, Child-Pugh score and adverse reactions (allergic rash, stomach discomfort, diarrhea) were observed and evaluated in the two groups. Results: After 4 weeks and 8 weeks of treatment, the CRP, IL-6, PCT, TBiL, ALT, AST, GGT, TBA, MELD scores and Child-Pugh scores of the observation group were lower than those of the control group (all P<0.05). The incidence of adverse reactions in the observation group was 11.76%, which was the same as the control group (χ2=0.159, P>0.05). Conclusion: Reduced glutathione combined with polyene phosphatidylcholine treatment can not only improve liver function, but also reduce inflammation, and has high safety and a good prognosis. 2021 Vol. 27 (7): 1076-1080 [Abstract] ( 116 ) HTML (1 KB)  PDF (1268 KB)  ( 207 ) 1081 Silk Fibroin/Hydroxyapatite Composite Promotes Bone Defect Repair by Inhibiting NF - κ B / NLRP3 LI Shiyan, LI Yanbo, CAO Lei, et al DOI: 10.3969/j.issn.1006-6233.2021.07.005 Objective: To study the effect of silk fibroin hydroxyapatite (HA) composite on inflammatory reaction in repairing rabbit bone defect. Methods: A total of 16 New Zealand white rabbits were divided into two groups. 15mm long radial segmental bone defect model was made in the operation groups. According to the different transplantation materials, the rabbits were divided into two groups. One group was implanted with HA, the other group was implanted with SF surface modified HA. The mRNA expression of IL-1 β and IL-18 were detected by real-time fluorescent quantitative polymerase chain reaction (RT PCR) 48 hours after operation. The protein expression levels of NF - κ B and NLRP3 were detected by Western blot. Results: Compared with the tissue-engineered bone prepared by HA culture with SF surface modification, the mRNA levels of IL-1 β and IL-18, as well as the protein expression levels of NF-κB and NLRP3 were significantly decreased. Conclusion: Silk fibroin hydroxyapatite composite can promote bone defect repair by inhibiting NF-κB/NLRP3 mediated inflammatory reaction. 2021 Vol. 27 (7): 1081-1084 [Abstract] ( 108 ) HTML (1 KB)  PDF (1356 KB)  ( 180 ) 1085 Correlation Between Bone Metabolism Indicators and Thyroid Hormones in Patients with Hyperthyroidism and Predictive Value on Hyperthyroidism Osteoporosis MA Xingpo, NIU Min, SHEN Jinfu, et al DOI: 10.3969/j.issn.1006-6233.2021.07.006 Objective: To observe the changes of bone metabolism in patients with hyperthyroidism and their relationship with thyroid hormones and hyperthyroid osteoporosis. Methods: 176 patients with hyperthyroidism who were admitted from September 2017 to September 2020 were selected as hyperthyroidism group, and 100 healthy controls were selected as control group. The thyroid hormones [total triiodothyronine (TT3), free triiodothyronine (FT3), total thyroxine (TT4), free thyroxine (FT4), thyroid-stimulating hormone (TSH)] and bone metabolism indexes [25-hydroxyvitamin D [25-(OH)-D], total aminoterminal propeptide of type I procollagen (TPINP), β-Crosslaps (β-CTX), N-terminal osteocalcin (N-MID)] were compared between the two groups. Pearson correlation analysis was used to analyze the correlation between bone metabolism indexes and thyroid hormones. Bone mineral density (BMD) was used to evaluate whether hyperthyroidism were complicated with osteoporosis. Based on this, the patients were divided into osteoporosis group and non-osteoporosis group. The differences of the above bone metabolism indexes were compared between the two groups, and receiver operating characteristic (ROC) curve was plotted to analyze the predictive value of bone metabolism indexes on hyperthyroid osteoporosis. Results: The levels of serum TT3, FT3, TT4 and FT4 in hyperthyroidism group were significantly higher than those in control group (P<0.05), while the TSH level was significantly lower than that in control group (P<0.05). The 25-(OH)-D level was significantly lower than that in control group (P<0.05), while the levels of TPINP, β-CTX and N-MID were significantly higher than those in control group (P<0.05). Serum 25-(OH)-D in patients with hyperthyroidism was negatively correlated with TT3, FT3, TT4 and FT4 (P<0.05). TPINP was positively correlated with FT3 and FT4 (P<0.05). β-CTX was positively correlated with TT3, FT3, TT4 and FT4 (P<0.05), and was negatively correlated with TSH (P<0.05). N-MID was positively correlated with TT3, FT3, TT4 and FT4 (P<0.05), and was negatively correlated with TSH (P<0.05). The detection rate of osteoporosis among 176 patients with hyperthyroidism was 23.30% (41 cases). The level of 25-(OH)-D in osteoporosis group was significantly lower than that in non-osteoporosis group (P<0.05), while the levels of TPINP, β-CTX and N-MID were significantly higher than those in non-osteoporosis group (P<0.05). The areas under the ROC curves (AUC) of 25-(OH)-D, TPINP, β-CTX and N-MID in predicting hyperthyroid osteoporosis were 0.660, 0.721, 0.641 and 0.639 (P<0.05), and the AUC of the combination of the four was 0.786 (P<0.05). Conclusion: Serum 25-(OH)-D of patients with hyperthyroidism is abnormally decreased, while TPINP, β-CTX and N-MID are abnormally increased, and the above indexes are closely related to the levels of thyroid hormones. The combined detection of 25-(OH)-D, TPINP, β-CTX and N-MID has a certain predictive value on hyperthyroid osteoporosis. 2021 Vol. 27 (7): 1085-1089 [Abstract] ( 136 ) HTML (1 KB)  PDF (1416 KB)  ( 236 ) 1090 Correlation Analysis of Serum EGF YKL-40 SAA Levels and Cognitive Impairment of Patients with Parkinson's Disease SUN Ni, SHI Jing, LIU Gui'an DOI: 10.3969/j.issn.1006-6233.2021.07.007 Objective: To explore the correlation between the level of serum human cartilage glycoprotein 39 (YKL-40), epidermal growth factor (EGF), amyloid A (SAA) and cognitive impairment of patients with Parkinson's disease (PD). Methods: A total of 62 PD patients admitted to our hospital from May 2019 to May 2020 were selected as the observation group, and 60 healthy controls during the same period for physical examination were selected as the control group. Analyze the serum YKL-40, EGF, and SAA levels of the observation group and the control group, the Montreal Cognitive Assessment Scale (MoCA) score, and record the observation group’s Parkinson’s disease unified score scale (UPDRS) score. Pearson was used to analyze the correlation between UPDRS score, MoCA score and serum YKL-40, EGF, SAA levels in PD patients. Results: The serum YKL-40, EGF and SAA levels of the observation group were significantly higher than those of the control group, and the MoCA score was significantly lower than that of the control group. There was a statistical difference between the two groups (P<0.05). The condition of patients in the observation group was recorded, including UPDRS Ⅰ (3.84 ± 0.47) points, UPDRS Ⅱ (23.83 ± 3.07) points, and UPDRS Ⅲ (29.9 ± 3.49) points. Pearson was used to analyze the correlation between UPDRS score, MoCA score and serum YKL-40, EGF, SAA levels in PD patients, and the results showed that serum YKL-40、EGF, SAA levels were negatively correlated with MoCA score (r = -0.425, -0.548,- 0.455, P<0.01), and UPDRSⅠ (r=0.604, 0.645, 0.592, P<0.01), UPDRSⅡ (r=0.559, 0.527, 0.636, P<0.01), UPDRSⅢ (r=0.584, 0.709, 0.613, P<0.01) 0.01). The scores were positively correlated. Conclusion: The levels of serum YKL-40, EGF and SAA in PD patients are significantly increased, and are closely related to the patient's condition and cognitive impairment. The index levels have certain reference value for clinical early detection and treatment. 2021 Vol. 27 (7): 1090-1093 [Abstract] ( 103 ) HTML (1 KB)  PDF (1200 KB)  ( 150 ) 1094 Effect of Entecavir Combined with Polyene Phosphatidylcholine on Average Platelet Volume Blood Uric Acid and TGFβ1 in Patients with Chronic Hepatitis B Combined with NAFLD LI Xiao, SHI Jie, et al DOI: 10.3969/j.issn.1006-6233.2021.07.008 Objective: To analyze the effect of entecavir combined with polyene phosphatidylcholine treatment on average platelet volume, blood uric acid and TGFβ1 in patients with chronic hepatitis B combined with non-alcoholic fatty liver disease. Methods: The 146 patients with CHB combined with NAFLD admitted to this hospital from January 2017 to August 2019 were retrospectively analyzed. According to different treatment methods, patients were divided into the conventional group (conventional + entecavir treatment), 68 cases, and the combined group (entecavir + polyene phosphatidylcholine treatment), 78 cases. The clinical effects, mean platelet volume (MPV), serum uric acid (BUA), transforming growth factor β1 (TGFβ1), liver function and adverse reactions after treatment were compared between the two groups. Results: After treatment, the total clinical effective rate of the conventional group was 75.00%, which was significantly lower than that of the combination group (88.46%) (P<0.05). After treatment, the levels of MPV, BUA, and TGFβ1 all declined, and the declining in the combined group after treatment was significantly greater than that in the conventional group(P<0.05). After treatment, the liver function of the two groups improved. After treatment, the differences in AST, TBIL, and ALB levels in the combined group before and after treatment were significantly greater than those in the conventional group(P<0.05). After treatment, the total incidence of adverse reactions was 1.47% in the conventional group and 2.56% in the combination group. There was no difference between the two groups (P>0.05). Conclusion: Entecavir combined with polyene phosphatidylcholine therapy can reduce the levels of MPV, BUA and TGFβ1 in patients with CHB and NFALD, delay the progression of the disease, improve liver function, and improve the therapeutic effect. 2021 Vol. 27 (7): 1094-1098 [Abstract] ( 270 ) HTML (1 KB)  PDF (1255 KB)  ( 938 ) 1099 Correlation Between Caffeine Citrate Combined with PS on Lung Function and Serum NT-ProBNP and IL-6 Levels in Neonates with Respiratory Distress Syndrome QIN Jianpin, YANG Qin, et al DOI: 10.3969/j.issn.1006-6233.2021.07.009 Objective: To study the correlation between caffeine citrate combined with pulmonary surfactant (PS) on lung function and serum levels of amino-terminal pro-brain natriuretic peptide (NT-ProBNP) and interleukin-6 (IL-6) in children with neonatal respiratory distress syndrome (NRDS). Methods: Eighty children with NRDS who were treated in our hospital from July 2019 to July 2020 were randomly divided into observation group and control group, with 40 cases in each group. The control group was treated with PS, while the observation group was treated with caffeine citrate on the basis of the control group. Clinical efficacy, pulmonary function index, serum levels of NT-proBNP and IL-6 and complication rate were compared between the two groups. Results: After treatment, the total effective rate in the observation group was significantly higher than that in the control group (P<0.05). The ratio of time to peak tidal expiratory flow and total expiratory time in observation group after treatment, TPEF/TE), ratio of expiratory volume at peak tidal flow and total expiratory volume (VPEF/VE) and Tidal volume/kg (VT/kg) were significantly higher than those of the control group (P<0.05). After treatment, the levels of NT-proBNP and IL-6 in the observation group were significantly lower than those in the control group (P<0.05). Compared with the control group, the incidence of complications in the observation group decreased significantly (P<0.05). Conclusion: Caffeine citrate combined with PS has a significant clinical effect on children with NRDS, which is related to the improvement of lung function and the regulation of serum NT-proBNP and IL-6 levels, and can effectively avoid complications. 2021 Vol. 27 (7): 1099-1103 [Abstract] ( 134 ) HTML (1 KB)  PDF (1476 KB)  ( 204 ) 1104 Clinical Efficacy and Mechanism of Hulisan Capsule combined Nail Internal Fixation on Garden Type Ⅲ and Ⅳ Femoral Neck Fractures in Young and Middle-aged Patients WANG Rongsheng, HAN Xue, WANG Jing, et al DOI: 10.3969/j.issn.1006-6233.2021.07.010 Objective: To investigate the clinical curative effect and the mechanism of Hulisan capsule combined nail internal fixation on GardenⅢ, Ⅳyoung and middle-aged femoral neck fracture.Methods: 130 patients with femoral neck fractures were divided into control group and combined treatment group. Patients in the control group were treated with nail internal fixation, and patients in the combined treatment group were treated with Hulisan capsule after nail internal fixation. Fracture healing, femoral head necrosis rate, incidence of femoral neck shortening, serum oxidative stress and inflammatory factors concentration and hip joint function of patients in the two groups were observed. Results: After surgery, the patients received Hulisan capsule combined nail internal fixation showed the fracture healing time was significantly shorter (P<0.01) and fracture healing rate increased significantly (P<0.05), and 6 months after operation, femoral head necrosis rate and incidence of femoral neck shortening significantly decreased (P<0.05), serum oxidative stress indicators increased significantly(P<0.01), serum inflammatory factors indicators decreased significantly(P<0.01),Harris hip score increased significantly (P<0.01), and Harris hip function evaluation effect of excellent and good rate increased significantly (P<0.05).Conclusion: Hulisan capsule combined nail internal fixation treatment significantly improved fracture healing and femoral head necrosis rate, improve the patient's hip joint function of GardenⅢ, Ⅳ young and middle-aged femoral neck fracture. Its mechanism of action may be achieved through anti-oxidative stress and anti-inflammation. 2021 Vol. 27 (7): 1104-1107 [Abstract] ( 111 ) HTML (1 KB)  PDF (1246 KB)  ( 143 ) 1108 Effect of Sevoflurane or Propofol Combined with Remifentanil on Patients Undergoing Laparoscopic Inguinal Hernia Surgery ZHANG Dalei, HOU Guiting, WANG Xin, et al DOI: 10.3969/j.issn.1006-6233.2021.07.011 Objective: To study the efficacy of remifentanil combined with sevoflurane and propofol in patients with laparoscopic inguinal hernia surgery. Methods: 80 patients with inguinal hernia who underwent laparoscopic surgery in our hospital from August 2018 to August 2020 were selected, according to the tool list of random distribution sequence, they were divided into group A and group B, 40 cases in each group. The group A was given remifentanil combined with sevoflurane for anesthesia maintenance, and group B was given remifentanil combined with propofol for anesthesia maintenance. The perioperative situation, systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), steward recovery score after extubation, respiratory quotient (RQs) after skin incision, plasma cortisol, blood glucose and adrenocorticotropic hormone (ACTH) levels before anesthesia and at the end of operation were compared between the two groups, and the incidence of adverse reactions was observed. Results: The recovery time and extubation time in group A were (6.03±1.50)min, (9.34±1.63)min, which were significantly shorter than those in group B (7.28±1.76)min,(12.30±2.04)min, with statistically significant (P<0.05). SBP, DBP, HR, steward wake-up score, RQs, plasma cortisol, blood glucose and ACTH levels of the two groups were statistically significant (P<0.05) and had interaction (P<0.05); SBP, DBP and HR levels at 5 min after intubation (T1), 15 min after artificial pneumoperitoneum (T2), 30 min after artificial pneumoperitoneum (T3) and at the end of operation (T4) in the two groups were higher than those before operation (T0), and the increase degree in group A was less than that in group B (P<0.05); At extubation and 10 minutes after extubation, the steward recovery score of group A was (4. 75 1 ± 50), (5. 21 0 ± 37), which were higher than (4. 22 0 ± 47), (4. 86 0 ± 49), the difference was statistically significant (P<0.05); During the whole operation, the RQs of group B was lower than that of group A, and the RQs of group B was significantly lower than that of group A at 0 ~ 1H (P<0.05). At the end of operation, the levels of plasma cortisol, blood glucose and ACTH in the two groups were significantly higher than those before anesthesia (P<0.05); At the end of operation, the levels of plasma cortisol, blood glucose and ACTH in group B were significantly lower than those in group A (P<0.05). The total adverse reaction rates of group A and group B were 15.00% and 17.50% respectively, and there was no statistical significance (P>0.05). Conclusion: Remifentanil combined with sevoflurane in laparoscopic inguinal hernia surgery has significant anesthetic effect, which helps to ensure stable blood flow, shorten the recovery time and extubation time, improve the quality of recovery, and has good safety. Propofol can significantly reduce the body protein decomposition during anesthesia, play the role of nitrogen saving, and also significantly inhibit the intraoperative stress response. 2021 Vol. 27 (7): 1108-1113 [Abstract] ( 102 ) HTML (1 KB)  PDF (1288 KB)  ( 144 ) 1114 Correlation Between MicroRNAs of Serum and Endothelial Cell Function in Elderly Patients with Acute Myocardial Infarction and Heart Failure GULIZIREMU Abudumanafu, LI Na DOI: 10.3969/j.issn.1006-6233.2021.07.012 Objective: To investigate the correlation between serum microRNAs and vascular endothelial cell function in elderly patients with acute myocardial infarction and heart failure. Methods: From January 2018 to December 2020, 56 elderly patients with acute myocardial infarction and heart failure in our hospital were retrospectively collected as an observation group, while 93 patients with simple myocardial infarction in our hospital were collected as a control group. The serum levels of miRNA-145, miRNA-19b and miRNA-96 were detected, and the correlation between serum miRNA-145, miRNA-19b and miRNA-96 and vascular endothelial cell function were analyzed. Results: Compared with the control group, miRNA-145, miRNA-19b and miRNA-96 in the observation group were significantly increased (1.76 ± 0.32 vs 1.04 ± 0.31, P<0.001, 1.52 ± 0.44 vs 1.08 ± 0.37, P<0.001, 2.76 ± 0.54 vs 1.43 ± 0.62, P<0.001, respectively). Pearson linear correlation showed that miRNA-145, miRNA-19b and miRNA-96 were negatively correlated with FMD, NO and LVEF, and positively correlated with ET-1 and NT-Pro BNP (P<0.05). Conclusion: The miRNA-145, miRNA-19b and miRNA-96 are significantly increased in patients with acute myocardial infarction and heart failure, and are related to the function of vascular endothelial cells. 2021 Vol. 27 (7): 1114-1117 [Abstract] ( 94 ) HTML (1 KB)  PDF (1257 KB)  ( 133 ) 1118 Effect of Laryngeal Mask Combined with LPSV on Pulmonary Function Pulmonary Complications and Serum SP-A in Patients Undergoing Laparotomy WANG Xin, WANG Lu, WANG Liwei DOI: 10.3969/j.issn.1006-6233.2021.07.013 Objective: To observe the effects of laryngeal mask combined with LPSV on lung function, pulmonary complications and serum SP-A in patients undergoing laparotomy. Methods: 60 patients who underwent elective laparotomy in General Department of our hospital from July 2018 to July 2020 were selected as the study object prospectively. The patients in the control group (30 cases) were divided into two groups randomly and simply by random, the control group (30 cases) as LPSV, and the observation group was laryngeal mask combined with LPSV (30 cases). The clinical indexes, pulmonary function indexes, pulmonary complications, serum biochemical factors were collected and compared. Results: There was no significant difference in clinical indexes between 2 groups (P>0.05). Ventilation indexes MVV, FVC, ventilation indexes PEF and FEF25 in the control group were significantly lower than those before surgery, the differences were statistically(P<0.05). Ventilation indexes FEF25 in the observation group were significantly lower than those before surgery, the differences were statistically significant (P<0.05). Ventilation indexes MVV, FVC, FEV1, ventilation indexes PEF and FEF25 in observation group were significantly higher than those in control group, the differences were statistically significant(P<0.05). The incidence of pulmonary infection, pleural effusion and atelectasis in the observation group were 3.33%, 0%, 0%, significantly lower than that in the control group 23.33%, 13.33%, 13.33%, the differences were statistically significant(P<0.05). Serum SP-A in 2 groups on day 1 after surgery was significantly higher than that before surgery and 7 days after surgery, the differences were statistically significant(P<0.05). The level of serum SP-A in the observation group was significantly lower than that in the control group on day 1 and day 7 after surgery, the differences were statistically significant(P<0.05). Conclusion: Laryngeal mask combined with PCV can reduce lung function injury, lung complication rate, and serum SP-A level. 2021 Vol. 27 (7): 1118-1122 [Abstract] ( 100 ) HTML (1 KB)  PDF (1224 KB)  ( 152 ) 1123 Effect of Bronchoalveolar Lavage via Fiberoptic Bronchoscope on Severe Pneumonia and the Efficacy of Arterial Blood Gas and Respiratory Dynamics WU Yao, PENG Jie, XIE Mei, et al DOI: 10.3969/j.issn.1006-6233.2021.07.014 Objective: To investigate the effect of bronchoalveolar lavage by fiberoptic bronchoscope in the treatment of severe pneumonia and the efficacy of arterial blood gas and respiratory dynamics. Methods: A total of 118 patients with severe pneumonia who were admitted to the hospital from September 2017 to September 2020 were enrolled as subjects. According to the simple random method, They were divided into control group (n=58) and observation group (n=60). The control group was given routine comprehensive medical treatment, while observation group was treated with bronchofibroscopic BAL. The duration of cough, disappearance time of lung rales, hospitalization time, clinical curative effect, Arterial blood gas index [Ⅱ acute physiology and chronic health evaluation system (APACHE Ⅱ), arterial blood CO2 partial pressure (PaCO2), blood oxygen saturation (SaO2), arterial blood oxygen partial pressure (PaO2)], respiratory dynamics indexes [dynamic compliance (Cdyn), airway resistance (Raw), work of breathing (WOB)] and levels of inflammatory factors [interleukin-6 (IL-6) interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α)] were compared between the two groups. Results: The duration of cough, disappearance time of lung rales and hospitalization time in observation group were shorter than those in control group (P<0.05), and response rate of treatment was higher than that in control group (88.33% VS 70.69%) (P<0.05). In observation group, SaO2, PaO2 level were higher than the control group after treatment, the APACHE Ⅱ score, PaCO2, Raw, WOB, IL - 6, IL - 8, TNF alpha were lower than the control group (P<0.05). Conclusion: Bronchoalveolar lavage via fiberoptic bronchoscope is effective in the treatment of severe pneumonia, which can improve arterial blood gas index and respiratory dynamics, and reduce inflammatory factors. 2021 Vol. 27 (7): 1123-1126 [Abstract] ( 93 ) HTML (1 KB)  PDF (1188 KB)  ( 271 ) 1127 Levels and Clinical Significance of Peripheral Blood Regulatory T Lymphocytes IL-10 and SIgE in Children with Bronchial Asthma WANG Ruqiong, LI Xiaoming, LIN Daojiong, et al DOI: 10.3969/j.issn.1006-6233.2021.07.015 Objective: To explore the clinical guiding significance through detecting the levels of peripheral blood regulatory T lymphocytes, serum interleukin-10 (IL-10) and specific IgE (sIgE) in bronchial asthma children allergic to Dermatophagoides pteronyssinus. Methods: From February 2018 to February 2020, 163 children with bronchial asthma who were allergic to Dermatophagoides pteronyssinus were selected as study subjects. According to the severity of the disease, they were divided into mild group (52 cases), moderate group (63 cases), and severe group (48 cases). Meanwhile, 50 healthy children of the same age were selected as the control group. The peripheral blood lymphocytes were isolated, and then cultured for 48 hours under the stimulation of Dermatophagoides pteronyssinus leachate. Flow cytometry was used to detect the percentages of adaptive regulatory T cells (iTreg) and type I regulatory T cells (Tr1). In addition, the lung function, serum IL-10, TGF-β and sIgE levels were compared among groups. Results: Comparison of the control group and the diseased group found that the severer the disease, the lower the forced expiratory volume in the first second (FEV1), the FEV1 to forced vital capacity (FVC) ratio (FEV1/FVC) and peak expiratory flow (PEF), the lower the proportions of iTreg and Tr1, showing statistically significant differences (P<0.05). Comparison of immune factor levels between the control group and the diseased group found that the severer the disease, the lower IL-10 and TGF-β levels (P<0.05), and the higher the sIgE level (P<0.05). Conclusion: The detection of lung function indexes, IL-10 secreting regulatory T lymphocytes and immune factors IL-10, TGF - β and SiGe levels in children with bronchial asthma not only helps to evaluate the severity of the disease, but also helps to provide reference for the prognosis of the disease in the process of treatment.. 2021 Vol. 27 (7): 1127-1130 [Abstract] ( 104 ) HTML (1 KB)  PDF (1257 KB)  ( 246 ) 1131 Effect of Posterior Medial Branch of Spinal Nerve Block on Pain Relief ODI Index Score and JOA Score in Patients with Low Back Pain HUANG Fei, LIU Junwu, CHEN Tingting, et al DOI: 10.3969/j.issn.1006-6233.2021.07.016 Objective: To investigate the effect of posterior medial branch of spinal nerve block on pain relief, ODI index score and JOA score in patients with low back pain. Methods: The selected study objects are 96 patients with low back pain from February 2016 to February 2020. A simple random grouping method is adopted through the random number table. The patients were divided into control group (given conventional treatment) and observation group (given posteromedial spinal nerve block surgery), each with 48 cases, and the VAS score and ODI index score, low back muscle extension activity (ROM), isometric muscle strength (IMS), JOA score, quality of life were observed and evaluated. Results: After 1 week, 4 weeks, and 8 weeks of treatment, the VAS score and ODI index score of the observation group were lower than those of the control group, while the scores of ROM, IMS, subjective symptoms, clinical signs, limitations of daily life, physical health, mental health, and social relationship, independence and environmental factors were higher than those of the control group (P<0.05). Conclusion: The posterior medial branch of spinal nerve block can not only improve lumbar spine function, but also relieve pain in patients with low back pain, and has high application value. 2021 Vol. 27 (7): 1131-1136 [Abstract] ( 140 ) HTML (1 KB)  PDF (1393 KB)  ( 621 ) 1137 Relationship Between Serum Hb ALB BMI and Pulmonary Infection in Maintenance Hemodialysis Patients CHEN Ruijuan, WU Yuechun, DING Honglian, et al DOI: 10.3969/j.issn.1006-6233.2021.07.017 Objective: To study the relationship between serum hemoglobin (HB), serum albumin (ALB), body mass index (BMI) and pulmonary infection in maintenance hemodialysis patients and the risk factors of pulmonary infection. Methods: A total of 81 patients with maintenance hemodialysis in our hospital from January 2016 to January 2020 were selected as the research objects. According to whether pulmonary infection occurred in patients during hemodialysis treatment, all patients were divided into infection group (23 cases) and non-infection group (58 cases). Gender, age, BMI, length of first dialysis stay, vascular access, hypertension, diabetes, smoking history, Hb and ALB expression levels were compared between the two groups. ROC curve was used to analyze the value of serum Hb, ALB and BMI in predicting pulmonary infection in maintenance hemodialysis patients; Non- conditional logistic stepwise regression was used to analyze the influencing factors of pulmonary infection in maintenance hemodialysis patients. Results: By univariate analysis, compared with the non-infection group, the proportion of patients with age ≥ 60 years, diabetes mellitus and smoking history in the infection group was higher, and the BMI, Hb and ALB levels in the infection group were higher, and the differences were statistically significant (P<0.05); ROC analysis showed that the area under the curve of BMI, Hb and ALB in predicting pulmonary infection in maintenance hemodialysis patients was 0.804, 0.804 and 0.850, respectively, and the differences were statistically significant (P<0.05); Logistic regression analysis confirmed that age ≥ 60 years old, BMI ≥ 24.205kg/m2, diabetes mellitus, smoking history, Hb ≤ 82.875g/l, ALB ≤ 33.445g/l were the risk factors of pulmonary infection in maintenance hemodialysis patients, the differences were statistically significant (P<0.05). Conclusion: Age, diabetes and smoking history are independent risk factors for pulmonary infection in maintenance hemodialysis patients. BMI, Hb and ALB have certain predictive value for pulmonary infection in maintenance hemodialysis patients 2021 Vol. 27 (7): 1137-1140 [Abstract] ( 107 ) HTML (1 KB)  PDF (1364 KB)  ( 182 ) 1141 Correlation Analysis of Blood Lipid Ratio Chemerin Level and Severity of Coronary Artery Disease in Patients with Acute Coronary Syndrome ZHAO Yuanyuan, DING Zhenjiang, TIAN Yanan, et al DOI: 10.3969/j.issn.1006-6233.2021.07.018 Objective: To investigate the relationship between the serum lipid ratio and Chemerin level in patients with acute coronary syndrome (ACS) and the severity of coronary artery disease, to evaluate the clinical predictive value of the ratio of serum lipids and Chemerin level in patients with acute coronary syndrome (ACS). Methods: 230 patients who had done the coronary angiography in our hospital from July 2019 to January 2020 were selected that met the inclusion criteria, and their medical records and clinical examination data were collected and divided into ACS group (164 cases) and control group (66 cases). ACS group included unstable angina pectoris group (87 cases) and acute myocardial infarction group (77 cases). At the same time, Gensini score was divided into three groups: low group, medium group and high group. The differences of blood lipid ratio and Chemerin level among the groups and the correlation with the severity of coronary artery disease were analyzed. Results: Comprehensive analysis showed that the levels of TC / HDL-C, TG / HDL-C, non-HDL-C / HDL-C, LDL-C / HDL-C, LCI and Chemerin in ACS group were significantly higher than those in control group, and they were positively correlated with the severity of coronary artery disease (P<0.01), and Chemerin level was also positively correlated with TC / HDL-C, LDL-C / HDL-C, non-HDL-C / HDL-C (P<0.01). By establishing binary logistic regression model, Chemerin was found to be an independent risk factor for ACS (or = 1.03, P<0.01). The cut-off value of Chemerin in predicting ACS was 619.00ng/ml and the area under the ROC curve was 0.716( P<0.001,95%CI:0.649～0.783). Conclusion: The serum lipid ratio and Chemerin level in patients with acute coronary syndrome are significantly higher than those in the control group, and they are positively correlated with Gensini score. Meanwhile, the increase of Chemerin level can be used as an independent risk factor to predict ACS, and has high predictive value for ACS. 2021 Vol. 27 (7): 1141-1146 [Abstract] ( 117 ) HTML (1 KB)  PDF (1377 KB)  ( 235 ) 1147 Effects of Biotype Long-Stem Hip Replacement on Perioperative Indicators and Postoperative Recovery of Elderly Unstable Intertrochanteric Fractures CHEN Tinglin, LIN Jiuzao, HUANG Yufeng, et al DOI: 10.3969/j.issn.1006-6233.2021.07.019 Objective: To study the effects of biotype long-stem hip replacement on perioperative indicators and postoperative recovery of elderly unstable intertrochanteric fractures. Methods: 248 patients with unstable intertrochanteric fractures treated in our hospital from April 2014 to April 2019 were selected and divided into two groups by simple random grouping, with 124 cases in each group. They were given bioprosthesis and bone cement prosthesis under intravenous inhalation general anesthesia or continuous epidural anesthesia respectively to perform hemi-hip replacement therapy. The perioperative indicators, prosthetic stability, postoperative hip function and complications were compared between the two groups. Results: The operative time and first ambulation time in biotype group were significantly lower than those in bone cement group (P<0.05), and there were no statistically significant differences in the intraoperative blood loss and hospital stay between the two groups (P>0.05). The prosthesis sinking distance in biotype group was significantly lower than that in bone cement group (P<0.05), and the incidence rates of prosthesis loosening in the two groups were 3.23% and 4.84% respectively (P>0.05). The Harris scores were significantly increased in the two groups (P<0.05), and the Harris scores at 1, 3, 6 and 12 months after surgery in biotype group were higher than those in bone cement group (P<0.05). The recovery effect of hip function in biotype group at 12 months after surgery was obviously better than that in bone cement group (P<0.05), and the excellent and good rates in the two groups were 72.58% and 54.84% (P<0.05). The incidence rates of postoperative infection and bone cement poisoning in biotype group were significantly lower than those in bone cement group (P<0.05), and the incidence rates of postoperative complications in the two groups were 11.29% and 28.23% (P<0.05), and the case fatality rates were 3.23% and 4.84% respectively(P>0.05). Conclusion: Biotype long-stem hip replacement for elderly patients with unstable intertrochanteric fractures is beneficial to shorten the operative time, promote postoperative rehabilitation, improve the stability of prosthesis and the recovery effect of hip function, and reduce the risk of postoperative complications. 2021 Vol. 27 (7): 1147-1151 [Abstract] ( 81 ) HTML (1 KB)  PDF (1587 KB)  ( 139 ) 1152 Effect of Stapler Hemorrhoid Excision Combined with Partial Anal Sphincterotomy on Edema of Wound Margin and Anal Function after Severe Mixed Hemorrhoids Operation WANG Meng, NING Yuyong, WU Wei, et al DOI: 10.3969/j.issn.1006-6233.2021.07.020 Objective: To investigate the effects of surgical procedures for prolapseand oral sphincterotomy (PPH) combined with partial anal sphincterotomy for severe mixed hemorrhoids on postoperative wound edema and anal function. Methods: The data of 103 patients with severe mixed hemorrhoids admitted to the General Hospital of Anhui Wanbei Coal and Power group from January 2019 to November 2020 were retrospectively analyzed, and they were divided into the combined group (PPH + amputation, n = 52) and the control group (PPH alone, n = 51) according to different surgical methods. After 7 days of treatment, the total effective rate, postoperative edema and anal function of the two groups were observed and compared. Results: The total effective rate (100%) of the combination group was significantly higher than that of the control group (90.20%), and the difference was statistically significant (χ2=5.289, P<0.05). The postoperative edema in the combined group was significantly lighter than that in the control group, the difference was statistically significant (χ2=19.443, P<0.05). The postoperative wound edge edema score [(2.34±1.05) points] of the combined group was significantly lower than that of the control group [(5.24±2.67) points], and the difference was statistically significant (t=7.658, P<0.05). After 7 days of treatment, the difference between the anal function indicators of the anal canal resting pressure and diastolic pressure before and after treatment in the combined group was significantly higher than that of the control group, and the differences were statistically significant (t=6.449, 6.540, P<0.05). The total incidence of postoperative complications in the combined group (3.85%) was significantly lower than that in the control group (13.73%), and the difference was statistically significant (P<0.05). Conclusion: Compared with stapler hemorrhoidectomy, stapler hemorrhoidectomy combined with anal sphincterotomy in the treatment of severe mixed hemorrhoids can significantly improve the clinical efficacy, alleviate the edema of the wound margin, improve the anal function and reduce the incidence of postoperative complications. 2021 Vol. 27 (7): 1152-1156 [Abstract] ( 105 ) HTML (1 KB)  PDF (1214 KB)  ( 227 ) 1157 Efficacy and Safety of Regional Mastectomy Combined with Gland Shaping and Continuous Negative Pressure Perfusion in the Treatment of Plasma Cell Mastitis with Nipple Retraction XU Anwen, XIE Quan, LI Ting, et al DOI: 10.3969/j.issn.1006-6233.2021.07.021 Objective: To analyze the efficacy and safety of regional mastectomy combined with gland shaping and continuous negative pressure perfusion in the treatment of plasma cell mastitis (PCM) with nipple retraction. Methods: The clinical data of 112 PCM patients with nipple retraction in our hospital were retrospectively analyzed. Among them, 54 patients underwent regional mastectomy+gland shaping (control group), and 58 patients received regional mastectomy + gland shaping combined with continuous negative pressure perfusion (observation group). The clinical efficacy, postoperative recovery and occurrence of postoperative complications were recorded in the two groups, and the differences in postoperative breast pain and breast cosmetic effect were compared between the two groups. Results: Both groups were cured after operation. The times of dressing change, wound healing time, hospitalization time, healing time and the total incidence of postoperative complications in the observation group were lower than those in the control group (P<0.05), and the postoperative breast pain grade in the observation group was lower than that in the control group (P<0.05). There was no significant difference between the two groups (P>0.05). Conclusion: Regional mastectomy + gland shaping combined with continuous negative pressure perfusion has a good efficacy and few complications in the treatment of PCM, and it has a positive effect in promoting the postoperative rehabilitation of patients. 2021 Vol. 27 (7): 1157-1160 [Abstract] ( 108 ) HTML (1 KB)  PDF (1560 KB)  ( 237 ) 1161 Effects of Modified Borehole Drainage on Postoperative Intracranial Pneumatocele Remoteintracranial Hemorrhageand Short-term Prognosis in Patients with Chronic Subdural Hematoma ZHOU Hui, WANG Haiquan DOI: 10.3969/j.issn.1006-6233.2021.07.022 Objective: To explore the effects of modified borehole drainage on postoperative intracranial pneumatocele, remote intracranial hemorrhage and short-term prognosis in patients with chronic subdural hematoma. Methods: 120 patients with chronic subdural hematomawhowere admitted to the hospital from January 2017 to January 2020 were enrolled as research objects. They were randomly divided into observation group (61 cases) and control group (59 cases) according to the random number table method. The control group was treated with routine boreholedrainage, while observation group was treated with endoscopic assisted drilling drainage, In addition, the brain tissue recruitment of the observation group was significantly better than that of the control group (P<0.05). The general surgical indexes, postoperative complications, clinical curative effect and prognosis results at 1 month after surgery were compared between the two groups. Results: There was no significant difference in operation time between the two groups (P>0.05). The hospitalization time in observation group was significantly shorter than that in control group (P<0.05), incidence of postoperative intracranial pneumatocele, intracranial effusion and remote intracranial hemorrhage was lower than that in control group (P<0.05),and total clinical response rate was significantly higher than that in control group (98.36% vs 89.83%) (P<0.05). At 1 month after surgery, disability rate in observation group was significantly lower than that in control group (1.64%vs 10.17%) (P<0.05), and recurrence rate was significantly lower than that in control group (1.64% vs 11.86%) (P<0.05). Conclusion: The application of endoscopic assisted drilling drainage in patients with chronic subdural hematoma is not only beneficial to reduce the incidence of postoperative intracranial pneumatocele, intracranial effusion and remote intracranial hemorrhage, In addition, it is conducive to the rapid recovery of brain tissue, with better clinical curative effect, but also can reduce Postoperativerecurrence rate and disability rate, which is of certain positive significance in improving prognosis of patients. 2021 Vol. 27 (7): 1161-1165 [Abstract] ( 121 ) HTML (1 KB)  PDF (1207 KB)  ( 281 ) 1166 The Predictive Value of Integrated Cervical Cerebral Ultrasound on Coronary Stenosis of Patients with Intracranial and Extracranial Atherosclerotic Stenosis SHEN Jian, ZHANG Haoran, WANG Feng, et al DOI: 10.3969/j.issn.1006-6233.2021.07.023 Objective: To investigate the relationship between intracranial and extracranial atherosclerotic stenosis by using transcranial doppler (TCD) and carotid artery ultrasound. Methods: A total of 186 patients with coronary artery stenosis confirmed by coronary angiography in our hospital were divided into group A, 97 cases (coronary artery stenosis ≤ 2 branches) and group B, 89 cases (coronary artery stenosis ≥ 3 branches). Patients in both groups were examined by transcranial Doppler ultrasound (TCD) and carotid artery ultrasound. The stenosis of intracranial artery (group A: 1067, group B: 979), extracranial artery (group A: 776, group B: 712) were compared between the two groups.Results: The detection rates of intracranial and extracranial arterial stenosis were 5.2% (55 / 1067) and 10.18% (79 / 776) in group A, and 8.5% (83 / 979) and 17.13% (122 / 712) in group B, with statistical significance (P=0.003, P=0.001). In group A, 52 (39%) were mild stenosis, 47 (35%) were moderate stenosis, 35 (26%) were severe stenosis or occlusion; 61 (30%) were mild stenosis, 65 (32%) were moderate stenosis, 79 (38%) were severe stenosis or occlusion. The difference between the two groups was statistically significant (P=0.018). Conclusion: In patients with coronary heart disease, with the aggravation of intracranial and extracranial artery stenosis, the severity of coronary artery stenosis and the number of involved vessels are also increasing, and the two are positively correlated. We can evaluate coronary artery stenosis by examining intracranial and extracranial artery stenosis with integrated carotid brain ultrasound (TCD and carotid ultrasound). 2021 Vol. 27 (7): 1166-1168 [Abstract] ( 120 ) HTML (1 KB)  PDF (1237 KB)  ( 256 ) 1169 Comparative Study on the Efficacy and Safety of Laparoscopic Stability Tracking System and Laparoscopic Operation Assistant in Surgery WANG Xuan, WANG Shijun, ZHOU Lian'er, et al DOI: 10.3969/j.issn.1006-6233.2021.07.024 Objective: To explore the differences between laparoscopic stability tracking system and laparoscopic operation assistant in the effectiveness and safety of surgery. Methods: From January 29, 2019 to December 14, 2019, 100 patients who underwent laparoscopic minimally invasive surgery in the Department of Obstetrics and Gynecology, Xuanwu Hospital of Capital Medical University, Department of Gastrointestinal surgery and Obstetrics, People's Hospital of Peking University, and general surgery Department of the Third Hospital of Peking University were selected as the research objects. According to the central random method, they were divided into study group (n = 50) and control group (n = 50), Patients in the study group were treated with laparoscopic stable tracking system, while patients in the control group were treated with laparoscopic assistant. The efficacy and safety of the two groups were compared Results: Compared with the control group, the number of times of laparoscopic removal and cleaning and the graphic stability were significantly better in the study group, and the differences were statistically significant (P>0.05). There were no statistically significant differences between the two groups in terms of flexibility and effectiveness of operation, ease of use, and overall satisfaction with improving surgical efficiency (P>0.05). There was no statistically significant difference in the incidence of postoperative adverse events between the two groups (P<0.05). There was no significant difference in the rate of good wound healing between the two groups on day 1, day 2, and day 7-10 after surgery (P>0.05). Conclusion: Compared with the laparoscopic operation assistant, the video image stability obtained by the laparoscopic stable tracking system is significantly better, the number of laparoscopic removal and cleaning is less, and the operator's operation satisfaction and postoperative recovery of patients are no less than the laparoscopic operation assistant, which has better effectiveness and safety. 2021 Vol. 27 (7): 1169-1173 [Abstract] ( 122 ) HTML (1 KB)  PDF (1269 KB)  ( 197 ) 1174 Clinical Observation on the Treatment of Colorectal Cancer with Laparoscopically Assisted Colorectal Ectropion Surgery YANG Chun, ZHANG Chunxia, JIANG Tao DOI: 10.3969/j.issn.1006-6233.2021.07.025 Objective: To study the characteristics of laparoscopic-assisted colorectal ectropion and drag-out surgery for colorectal cancer, and to provide references for optimizing surgical procedures and related research. Methods: 66 colorectal cancer patients who were treated in Shenyang anal and intestinal hospital from July 2018 to July 2020 were selected prospectively. 66 patients were divided into experimental group (n = 33) and control group (n = 33 cases) according to simple random grouping method. The control group performed laparoscopic rectectomy, and the experimental group performed laparoscopic colorectal ectropion and pull out operation. The therapeutic effect of the two groups was evaluated 5 days after operation, and the operation indexes (bleeding, operation time, defecation times per day, intestinal recovery time and hospitalization time), recurrence rate and complication rate were observed and compared. Results: The average daily defecation times in experimental group was (9.62±1.22) times, which was significantly higher than that in control group (5.22±0.80) times, the difference was statistically significant (t=8.032, P<0.05). Comparison of operation time between the two groups [(157.23±43.42) min vs (163.04±40.45) min], the difference was not statistically significant (t=0.074, P>0.05). The postoperative intestinal recovery time [(2.11±0.50) d], intraoperative blood loss [(46.32±4.27) ml] and hospitalization time [(48.44±3.50) d] in experimental groups were significantly shorter or shorter than those in control group [(4.58±0.68) d], [(68.42±6.57) ml] and [(67.90±5.91) d], with statistical significance (t=7.540, 6.279, 7.097, P<0.05).The incidence of complications such as equincisional infection, postoperative anastomotic fistula, abdominal hemorrhage and subcutaneous emphysema in experimental group was significantly lower than that in control group, with statistical significance (P<0.05). The recurrence rate of 5 months after operation in experimental group was significantly lower than that in control group, with statistical significance (P<0.05). Conclusion: Laparoscopic pull-out surgery for colorectal eversion has the advantages of small trauma. And it can significantly reduce the recurrence rate and the incidence of complications and shorten the length of hospital stay. It has the value of promotion. 2021 Vol. 27 (7): 1174-1177 [Abstract] ( 123 ) HTML (1 KB)  PDF (1259 KB)  ( 239 ) 1178 Application Value of Srm-iv System in Diagnosis and Treatment of Superior Semicircular Canal Benign Paroxysmal Positional Vertigo YANG Qiuyun, MENG Nan, WEI Fuyi DOI: 10.3969/j.issn.1006-6233.2021.07.026 Objective: To observe the application value of SRM-IV system in the induction test of benign paroxysmal positional vertigo of superior semicircular canal (AC-BPPV). Methods: 110 patients with ac-bppv admitted to Baise people's Hospital from February 2018 to February 2021 were prospectively selected and randomly divided into experimental group (n = 55) and control group (n = 55) by simple random sampling method. The patients in the experimental group were treated with srm-iv diagnosis and treatment system, while the patients in the control group were treated with conventional manipulative reduction. Both groups were treated for 1 week. The total effective rate, cure time, subjective and objective symptoms, improvement of quality of life, occurrence of complications and recurrence rate of the two groups were compared after one week of treatment. Results: The total effective rate of the experimental group (96.36%) was significantly higher than that of the control group (81.82%), the difference was statistically significant( χ 2=11.652,P<0.05). The cure time of the experimental group [(6. 13 1 ± 66) D] was significantly shorter than that in the control group [(6. 99 0 ± 74) D], the difference was statistically significant (t = 5. 443, P< 0. 05). The difference of subjective and objective symptom related scores (UCLA-DQ, MSQ) before and after treatment in the experimental group [(2.46 0.05)] ± 14)] (63. 10 0 ± 59), which was significantly higher than that of the control group [(1. 58 6 ± 28) (49. 22 0 ± 41)]. The difference of quality of life (DHI) score before and after treatment [(36.12 1 ± 33), which was significantly higher than that of the control group [(22. 50 2 ± 10)]. The incidence of complications in the experimental group (3.64%) was significantly lower than that in the control group (18.18%), the difference was statistically significant (P<0.05). There was no significant difference in the recurrence rate between the experimental group (3.64%) and the control group (5.45%) (P>0.05). Conclusion: The SRM-IV diagnosis and treatment system plays an active role in the diagnosis and treatment of benign paroxysmal positional vertigo in the upper semicircular canal. The treatment effect is significant with few complications, safe and reliable, and at the same time, it significantly improves the subjective and objective symptoms and quality of life of patients. It is suitable for clinical practice and application. 2021 Vol. 27 (7): 1178-1181 [Abstract] ( 99 ) HTML (1 KB)  PDF (1257 KB)  ( 337 ) 1182 Guiding Effect of Magnetic Resonance Imaging in the Treatment of Patients with Reducible Atlantoaxial Dislocation YAO Lidong, TIAN Huawei, LIU Jie, et al DOI: 10.3969/j.issn.1006-6233.2021.07.027 Objective: To explore the effect of MRI on the diagnosis and treatment of patients with reproducible atlantoaxial dislocation. Methods: 94 patients with reversible atlantoaxial dislocation admitted in our hospital from January 2017 to January 2020 were selected as the test subjects and the clinical data were reviewed. The patients were examined by magnetic resonance, according to whether the front of the spinal cord was compressed. The incidence of postoperative complications, spinal cord compression index and JOA score of patients with reducible atlantoaxial dislocation were statistically analyzed. Results: There were 3 cases of vertebral artery injury, 6 cases of vascular injury and 2 cases of nerve injury in the observation group, and 1 case of vertebral artery injury and 2 cases of vascular injury in the control group; The incidence of postoperative complications in the observation group was higher than that in the control group (P<0.05). The decrease of spinal cord compression index in the observation group before and after operation was greater than that in the control group (P<0.05), and the decrease of spinal cord compression index in the last follow-up and before operation in the observation group was also greater than that in the control group (P<0.05). The JOA score of the observation group before and after operation increased more than that of the control group (P<0.05), and the JOA score of the observation group at the last follow-up and before operation also increased more than that of the control group (P<0.05). In the observation group, 18 cases were cured, 16 cases were markedly effective, and 4 cases were ineffective. In the control group, 26 cases were cured, 14 cases were markedly effective, and 16 cases were ineffective. The total effective rate of the observation group was significantly higher than that of the control group (P<0.05). Conclusions: Magnetic resonance can help to judge whether the patients with reducible atlantoaxial dislocation are compressed to a certain extent, so it has high reference significance for patients to take reducible atlantoaxial reduction surgery whether to take decompression operation, which is suitable for clinical promotion. 2021 Vol. 27 (7): 1182-1185 [Abstract] ( 108 ) HTML (1 KB)  PDF (1252 KB)  ( 162 ) 1186 Effects of Laparoscopic Radical Gastrectomy on Energy Metabolism Peripheral Blood TCell Subsets Intestinal Barrier Function Body's Inflammatory Stress Level and Immune Function in Patients with Gastric Cancer DAI Mengshuang, ZHANG Feng, JIA Tingting, et al DOI: 10.3969/j.issn.1006-6233.2021.07.028 Objective: To explore the effects of laparoscopic radical gastrectomy on energy metabolism, peripheral blood T cell subsets, intestinal barrier function, body’ s inflammatory stress level and immune function in patients with gastric cancer. Methods: A total of 142 patients with gastric cancer admitted to our hospital from June 2017 to June 2020 were selected as the research subjects. According to the surgical methods, 142 patients were divided into laparoscopic surgery group (observation group, n=75) and open surgery group (control group, n=67). The energy metabolism [albumin (ALB), prealbumin (PA), retinol binding protein (RBP), transferrin (TRF)], intestinal barrier function [diamine oxidase (DAO), D-lactic acid], inflammatory stress level [C reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)], peripheral blood T cell subsets (CD4+, CD8+, CD4+/CD8+) and immunoglobulins (IgA, IgG, IgM) were compared between the two before and after surgery. Results: At 3 days after surgery, the levels of serum ALB, PA, RBP, TRF, TNF-α, IgA, IgG and IgM and peripheral blood CD4+ and CD4+/CD8+in the two groups were decreased compared with those before surgery(P<0.05). At 3d after surgery, the levels of plasma DAO and D-lactic acid and serum CRP in the two groups were increased compared with those before surgery (P<0.05). At 1 day after surgery, the level of serum IL-6 in the two groups was higher than that before surgery (P<0.05). The changes of above indexes before and after surgery in observation group were lower than those in control group (P<0.05). Conclusion: Compared with open surgery, laparoscopic radical gastrectomy has less effect on energy metabolism, intestinal barrier function, inflammatory stress level and immune function, and it is beneficial to postoperative recovery. 2021 Vol. 27 (7): 1186-1190 [Abstract] ( 107 ) HTML (1 KB)  PDF (1263 KB)  ( 181 ) 1191 Protective Effect of Yangxin Dingji Capsule on Myocardial Ischemia Reperfusion Injury WANG Jing, et al DOI: 10.3969/j.issn.1006-6233.2021.07.029 Objective: To study the effect of Yangxindingji Capsule on nitrogen metabolism in myocardial tissue after ischemia-reperfusion injury. Methods: A model of rats with ischemia-reperfusion injury was established. The activities of LDH and CK in the myocardial tissue of the model rats were investigated. The content of antioxidant enzymes and lipid peroxidation products, the content of humic, spermine and polyamine in the tissues, Ornithine decarboxylase (ODC), spermine / spermine N-acetyltransferase activity (SSAT), nitric oxide (no) and nitrogen free radical content (ONOO-) were investigated. The mitochondrial related metabolic enzyme activity of myocardial tissue was detected. The effect of Yangxindingji capsule on the prognosis was evaluated. Results: The activities of LDH and CK isoenzyme in the myocardial tissue of the model rats were significantly increased, and the myocardial damage was significant. The content of polyamine, humic acid and spermine in the myocardial tissue of the model rats was significantly increased, the activity of ODC and SSAT increased, the NO content was significantly decreased, the activity of ONOO- of nitrogen free radical was significantly increased, the activity of superoxide dismutase, catalase and glutathione peroxidase in the myocardial tissue was significantly decreased, and the content of thiobarbituric acid reactant and lipid peroxide increased significantly, The oxidative stress response of myocardial tissue was significant. The mitochondrial metabolic enzymes isocitrate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, The activity of α-ketoglutarate dehydrogenase was significantly reduced, which indicating that the energy metabolism of mitochondria was abnormal. The results showed that the Yangxindingji capsule could significantly improve the myocardial injury, reduce the LDH and CK activity of myocardial injury index, and give yangxindingji capsule to dry prognosis, significantly reduce the activity level of ODC and SSAT, reduce the content of polyamine, humic, spermine, nitrogen free radical, restore the level of NO content, improved the metabolism of myocardial nitrogen, and restored the enzyme activity related to antioxidant damage in heart tissue, The content of thiobarbituric acid reactant and lipid peroxide was reduced, and the activity of mitochondrial metabolizing enzyme was restored.Conclusion: Yangxindingji capsule could significantly improve the abnormal nitrogen metabolism of myocardial tissue, reduce the content of amine, reduce nitrogen free radicals, restore the energy metabolism of myocardial tissue, and reduce the occurrence of myocardial tissue injury. 2021 Vol. 27 (7): 1191-1196 [Abstract] ( 127 ) HTML (1 KB)  PDF (1303 KB)  ( 171 ) 1197 Study on the Effect of Antibiotics on Pregnancy Outcome of Pregnant Women with Mild Bacterial Infections YAO Shuhui, et al DOI: 10.3969/j.issn.1006-6233.2021.07.030 Objective: To explore the effects of anti-infective drugs on the treatment of mild bacterial infections in pregnant women and the health of mothers and babies. Methods: From January 2019 to January 2020, 120 patients with mild bacterial infections during pregnancy who were admitted to Chengde Central Hospital were selected. All patients underwent normal obstetric examinations. According to simple random grouping, they were divided into observation group and control group, each with 60 cases. The observation group was treated with antibiotics after a mild bacterial infection during pregnancy, while the control group was not treated with antibiotics after a mild bacterial infection. The infection sites of the two groups of patients were compared, and the antibiotic usage in the observation group was counted. Compare the use of antibiotics on the impact of the two groups of pregnant women during the entire pregnancy, such as poor pregnancy (premature delivery, premature rupture of membranes, abortion, etc.), and at the same time the last B-ultrasound results (fetal double parietal diameter, femoral length , Birth weight, birth gestational age) for comparative analysis. Results: The distribution of the two groups of patients in the digestive system, respiratory system, urinary system, and reproductive system was relatively consistent, and there was no statistical difference (P>0.05); the types of antibiotics used in the observation group were as follows: 30 third-generation cephalosporins ( 50.00%), 18 cases of penicillins (30.00%), 6 cases of macrolides (10.00%), 4 cases of lincomycins (6.67%), and 2 cases of tetracycline antibiotics (3.33%). The most used is the third-generation cephalosporin. The incidence of adverse pregnancy (premature delivery, premature rupture of membranes, miscarriage, etc.) in the observation group was 8.33% (5/60), which was significantly lower than that of the control group (35.00%, 21/60), and the difference was statistically significant (χ2=12.570) , P<0.01); Compared with the control group, the observation group’s last B-ultrasound examination before labor, the developmental indicators such as the length of the double parietal diameter and the length of the femur, and the birth weight of the fetus were significantly increased, with statistical differences (P<0.05).Conclusion: Mild bacterial infections occur during pregnancy. Reasonable use of antibiotics can reduce the incidence of adverse pregnancy and is of great significance for improving the outcome of childbirth. 2021 Vol. 27 (7): 1197-1199 [Abstract] ( 98 ) HTML (1 KB)  PDF (1237 KB)  ( 169 ) 1200 Effect of Sequential Invasive-Non-Invasive Sequential Mechanical Ventilation on COPD Patients with Type II Respiratory Failure and Pulmonary Heart Disease GAO Jing, TENG Haifeng DOI: 10.3969/j.issn.1006-6233.2021.07.031 Objective: To discuss the effects of two different mechanical ventilation (invasive-non-invasive sequential mechanical ventilation and simple invasive mechanical ventilation) on blood gas, pulmonary function and ventilator associated pneumonia (VAP) in patients with chronic obstructive pulmonary disease (COPD) complicated with type II respiratory failure and pulmonary heart disease. Methods: From December 2017 to December 2018, 70 patients with COPD with pulmonary heart disease complicated with type Ⅱ respiratory failure were randomly divided into two groups: test group (n = 35) and control group (n=35). In the control group, 35 patients were given mechanical ventilation by endotracheal intubation first. After reaching the indication of non-invasive ventilation, the test group was changed to non-invasive mask mechanical ventilation, and the control group continued to be treated with simple invasive mechanical ventilation. Systolic blood pressure (SBP), arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2), pH, heart rate (HR), pulmonary function, mortality and VAP were measured before and after treatment in two groups. The incidence, the total duration of mechanical ventilation and the length of hospitalization were compared and analyzed. Results: There was no significant difference in SBP,PaO2,PaCO2, PH and HR between the two groups before and after treatment (P>0.05). The levels of SBP,PaO2, PH after treatment in both groups were significantly higher than those before treatment(t=-1.39,-2.99,-9.75,-12.60,-8.36,-8.36, all P<0.05), and the levels of HR and PaCO2 were lower than those before treatment (t=5.44,8.26,7.19,10.80, all P<0.05). There was no significant difference in pulmonary function between the two groups before treatment (P>0.05), but the pulmonary function indexes in two groups after treatment were significantly higher than those before the treatment (t=-2.69,-3.67, -5.45,-5.38, all P<0.05). The incidence of VAP in test group was 2.80. %, significantly lower than 20.00% in control group (χ2= 5.814, P<0.05), and the duration of mechanical ventilation in the test group was significantly shortened compared with control group (t = 5.196, P<0.05). The hospitalization time in test group was significantly lower than that in control group, and there was no significant difference in the mortality between the two groups (P>0.05). Conclusion: Invasive-non-invasive sequential mechanical ventilation can improve pulmonary function and reduce the incidence of ventilator-associated pneumonia in patients with COPD complicated with cor pulmonale with type Ⅱ respiratory failure. It is worthy of promotion and application in clinic. 2021 Vol. 27 (7): 1200-1204 [Abstract] ( 117 ) HTML (1 KB)  PDF (1217 KB)  ( 134 ) 1205 Clinical Value of Serum Glycosylated Hemoglobin and Albumin Levels in Predicting the Risk of Infection After Cesarean Section in Puerperae with Gestational Diabetes Mellitus PAN Juerong, WEI Hui, CHEN Ying, et al DOI: 10.3969/j.issn.1006-6233.2021.07.032 Objective: To explore the risk factors of infection after cesarean section in puerperae with gestational diabetes mellitus (GDM) and the predictive value of serum glycosylated hemoglobin (HbA1c) and albumin (Alb) on postoperative infection. Methods: The clinical data of 110 puerperae with GDM admitted from September 2017 to September 2020 were retrospectively analyzed. The levels of serum biochemical indicators such as fasting plasma glucose (FPG), HbA1c, hemoglobin (Hb), glycated albumin (GA), Alb and total cholesterol (TC) were detected among all puerperae in the morning before cesarean section. The occurrence of infection after cesarean section was counted, and the factors of general maternal data, surgical data and pregnancy-related complications that might affect postoperative infection were collected among all puerperae. Univariate analysis and multivariate logistic regression analysis were used to explore the risk factors affecting postoperative infection, and receiver operating characteristic (ROC) curve was plotted to explore the predictive value of serum indicators on postoperative infection. Results: The incidence rate of postoperative infection was 26.36% (29/110) among puerperae with GDM after cesarean section, including incision infection of 10.00% (11/110), urinary tract infection of 11.82% (13/110) and lung infection of 4.55% (5/110). There were statistically significant differences in the surgical incision length, intraoperative blood loss, presence or absence of prophylactic use of antibiotics, presence or absence of genital tract inflammation, amniotic fluid pollution and premature rupture of membranes and levels of serum FPG, HbA1c, GA and Alb between infection group and non-infection group of GDM puerperae after cesarean section (P<0.05). Multivariate logistic regression analysis showed that prophylactic use of antibiotics was a protective factor for infection after cesarean section in GDM puerperae (P<0.05), and the genital tract inflammation, amniotic fluid pollution, premature rupture of membranes, HbA1c>6.5% and Alb<40g/ L were independent risk factors for postoperative infection (P<0.05). The areas under the ROC curves of serum HbA1c, Alb and the combination of the two in predicting infection after cesarean section in GDM puerperae were 0.733, 0.700 and 0.797 respectively (P<0.05). Conclusion: There is a certain incidence rate of infection after cesarean section in GDM puerperae. Prophylactic use of antibiotics is the protective factor, and genital tract inflammation, amniotic fluid pollution, premature rupture of membranes and high serum HbA1c and low Alb levels are risk factors. The combined detection of serum HbA1c and Alb before surgery has a certain predictive value on postoperative infection. 2021 Vol. 27 (7): 1205-1209 [Abstract] ( 124 ) HTML (1 KB)  PDF (1338 KB)  ( 192 ) 1210 Predictive Value of Serum Levels of HMGB1, MiR-00-C-3p and CTn Ⅰ on the Prognosis of Neonatal Respiratory Distress Syndrome HUO Huiyi, LU Yongxue DOI: 10.3969/j.issn.1006-6233.2021.07.033 Objective: To explore the predictive value of serum levels of HMGB1, miR-200-c-3p and cTn Ⅰ level on the prognosis of neonatal respiratory distress syndrome. Methods: 120 children with NRDS treated between January 2016 and December 2019 in our hospital were chosen and divided into mild group (n=72, level I and II by X-ray results), severe group (n=48, level III and IV by X-ray results).In addition, 40 normal newborns in our hospital during the same period were selected as the control group. Serum HMGB1, miR-200-c-3p and cTn I level differences were compared between three groups and prognosis was predicted. Results: Serum HMGB1, miR-200c-3p and cTn I levels in the three groups were: severe grouP>mild group>control group (P<0.05).During hospitalization, 34 (28.33%) of 120 patients with NRDS died and 86 (71.67%) survived. There were no significant differences in age, sex, birth weight, maternal age, cesarean section, time of dyspnea, maternal diabetes, maternal hypertension, meconium inhalation, intrauterine distress, neonatal asphyxia, etc. between the two groups (P>0.05), but the differences in disease, HMGB1, miR-200c-3p and cTn I between the two groups were statistically significant (P<0.05). ROC curve analysis showed that the AUC of HMGB1, miR-200c-3p and CTN I in NRDS patients were 0.933, 0.892 and 0.766, with high accuracy. Taking the maximum tangent point of Youden index at the upper left of ROC curve as the optimal critical value, the sensitivity and specificity of HMGB1, miR-200c-3p and CTN I were 91.2%, 82.4%, 50.0% and 91.9%, 100.0% , 100.0% at this point, indicating a high predictive value. The AUC of the three combined predictions was 0.925, and the sensitivity and specificity were 85.3% and 98.8%, indicating high predictive value. Conclusion: Serum HMGB1, miR-200-c-3p and cTn I levels in children with NRDS has high expression, and is closely related to the degree of disease with high value of prognostic assessment. 2021 Vol. 27 (7): 1210-1214 [Abstract] ( 102 ) HTML (1 KB)  PDF (1370 KB)  ( 152 ) 1215 Correlation Between Heart Rate Variability and PCT in Patients with Kawasaki Disease and Its Value in Predicting Coronary Artery Injury LUO Jie, et al DOI: 10.3969/j.issn.1006-6233.2021.07.034 Objective: To explore the correlation between heart rate variability (HRV) and PCT in children with Kawasaki disease and its value in predicting coronary artery injury. Methods: 86 cases of children with Kawasaki disease diagnosed in our hospital from January 2017 to June 2019 were retrospectively selected, including 46 male patients and 40 female patients, aged 1 to 5 years, average age 2.53 ± 1.14 years old. All children underwent echocardiography before treatment. According to whether coronary artery damage occurred, they were divided into group A (coronary artery damage group, 42 cases) and group B (non-coronary artery damage group, 44 cases). Healthy children served as a control group. HRV indicators (time domain indicators, frequency domain indicators) were tested for children in each group, and the serum PCT levels of children in each group were detected by immunofluorescence chromatography. The three groups of children's HRV time domain indicators and frequency domain indicators were observed and compared, and the PCT levels of children in each group were compared. Results: The results showed that children with Kawasaki disease compared with normal children in the control group had statistically significant differences in HRV time-domain and frequency-domain indicators (P<0.05), and children in group A had significantly lower HRV indicators than group B. The difference was statistically significant (P<0.05). The serum PCT levels of children in groups A and B were significantly higher than those in the control group, and the serum PCT levels (2.85 ± 1.28 ng / ml) in group A were significantly higher than those in group B (1.26 ± 0.93 ng / ml) (P<0.05). Conclusion: There is a good correlation between heart rate variability (HRV) and serum PCT levels in children with Kawasaki disease. At the same time, the above two indicators can more accurately predict whether children will have coronary artery injury. It has good diagnostic value and is suitable for the early clinical diagnosis of Kawasaki disease and Kawasaki disease combined with coronary artery injury, so as to provide a basis for the timely treatment of children. It is worthy of clinical promotion. 2021 Vol. 27 (7): 1215-1218 [Abstract] ( 155 ) HTML (1 KB)  PDF (1256 KB)  ( 250 ) 1219 Effect of Pure Tumor Resection and Partial Pancreatectomy for Insulinoma on Blood Glucose Level and Prognosis LI Bing, ZHOU Huichao, WANG Qingguang DOI: 10.3969/j.issn.1006-6233.2021.07.035 Objective: To investigate the effect of simple tumor resection and partial pancreatectomy for insulinoma on the blood glucose level and prognosis of patients. Methods: 80 patients with insulinoma treated in our hospital from January 2017 to January 2020 were selected. According to different treatment methods, they were divided into resection group (43 cases, treated with simple tumor resection) and resection group (37 cases, treated with partial pancreatectomy). The changes of blood glucose level, prognosis and complications were compared between the two groups. Results: The FBG in the removal group was significantly higher at 1 day after surgery than before the operation (P<0.05), and the FBG at 30 days after surgery was significantly lower than before the operation (P<0.05), and the FBG in the resection group at 1d, 3, and 5 days after surgery FBG in the removal group was significantly lower than that in the resection group at 1d, 3d, 5d, and 7d after surgery (P<0.05). The FBG of the removal group was significantly lower than that of the resection group (P<0.05). There was no change in HbA1c in the two groups at 7d and 30d, and the HbA1c of the removal group was not statistically significant compared with the resection group (P>0.05). The average survival time of the removal group was significantly longer than that of the removal group (P<0.05). The incidence of short-term complications (27.91%vs21.62%) in the removal group was not statistically significant (P>0.05); the incidence of long-term complications (16.28%vs48.65%) in the removal group was significantly lower than the resection group (P<0.05). Conclusion: In the treatment of insulinomas of suitable size, the blood glucose level changes of simple tumor resection are less than that of partial pancreatectomy, the survival time of patients is relatively long, and the long-term complications after surgery are relatively fewer. 2021 Vol. 27 (7): 1219-1222 [Abstract] ( 119 ) HTML (1 KB)  PDF (1249 KB)  ( 133 ) 1223 Comparison of the Effects of Valsartan and Salcubatrium on Vascular Endothelial Function in Patients with Hypertension and Chronic Heart Failure LI Na, GULIZIREMU Abudumanafu DOI: 10.3969/j.issn.1006-6233.2021.07.036 Objective: To investigate the protective effect of sacubatre and valsartan on vascular endothelial function in patients with hypertension and chronic heart failure. Methods: A total of 159 patients with hypertension and chronic heart failure were simply randomly divided into observation group and control group, 80 cases in the observation group and 79 cases in the control group. The control group was treated with valsartan, and the observation group was treated with sacubitril valsartan, and both groups were treated for 6 months. The brachial artery endothelium-dependent vasodilation (EDD) function, serum nitric oxide (NO), endothelin-1 (ET-1), carotid intima-media thickness, glomerular filtration rate and left ventricular ejection fraction were compared between the two groups before and after treatment. Results: There was no significant difference in EDD, NO and ET-1 between the two groups before treatment (P>0.05). After treatment, compared with the control group, the EDD function of the observation group was significantly increased [(11.78 ± 3.25) vs (10.15 ± 3.17)%, P=0.002], the NO level was significantly increased [(97.24 ± 6.21) vs (82.61 ± 5.35) μmoL / L, P=0.000], and the ET-1 level was significantly decreased [(42.21 ± 7.14) vs (50.42 ± 6.36) ng / L, P=0.000]. There was no significant difference in carotid intima-media thickness, glomerular filtration rate and left ventricular ejection fraction between the two groups before and after treatment (P>0.05). Conclusion: Sacubitril valsartan have protective effect on vascular endothelial function in patients with hypertension and chronic heart failure. 2021 Vol. 27 (7): 1223-1226 [Abstract] ( 125 ) HTML (1 KB)  PDF (1197 KB)  ( 162 ) 1227 Effect of Ticagrelor on Unstable Angina Pectoris of Coronary Heart Disease on Human Plasma Lipoprotein-Related Phospholipase A2 and Cardiac Function WANG Jing, ZHANG Yingqiang, XU Yanjuan, et al DOI: 10.3969/j.issn.1006-6233.2021.07.037 Objective: To investigate the effect of ticagrelor on the plasma lipoprotein-related phospholipase A2 (Lp-PLA2) and cardiac function in patients with unstable angina pectoris of coronary heart disease. Methods: A total of 80 patients admitted to our hospital from July 2018 to May 2020 were selected and randomly divided into control group and study group with 40 cases in each by the random number table method. The control group received conventional treatment, and the study group was taking ticagrelor antiplatelet therapy on the basis of control group. The plasma Lp-PLA2, platelet indexes and cardiac function indexes were tested and compared and analyzed after the treatment. Results: After treatment, the maximum platelet aggregation rate of Lp-PLA2 in the study group was significantly lower than that of the control group (P<0.05), and the effective platelet inhibition rate was significantly higher than that of the control group (P<0.05); compared with the control group, SV, FS, EF and other cardiac function indexes of the study group after treatment were significantly higher, and LVDd was significantly lower (P<0.05); the clinical treatment effect of angina pectoris in the study group was significantly better than that of the control group. The results of multivariate logistic regression analysis showed that LpPLA2 was an independent risk factor for the efficacy of angina pectoris, and SV was a protective factor for the efficacy of angina pectoris. Conclusion: Ticagrelor can effectively inhibit platelet aggregation in patients with unstable angina pectoris of coronary heart disease, enhance the antiplatelet coagulation effect, effectively improve the heart function of patients, and the therapeutic effect is more significant. The therapeutic effect of angina pectoris is related to multiple factors such as Lp-PLA2 and SV. 2021 Vol. 27 (7): 1227-1232 [Abstract] ( 104 ) HTML (1 KB)  PDF (1223 KB)  ( 162 )

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