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2021 Vol. 27, No. 6 Published: 2021-06-30 881 Effects of Different Anesthesia Methods on the Expression of Apoptotic Gene in Spontaneous Hypertensive Rats with Intracerebral Hemorrhage ZHAO Guangping, CHEN Yongxue, ZHEN Shuqing, et al DOI: 10.3969/j.issn.1006-6233.2021.06.01 Objective: To explore the effects of different anesthesia methods on neuronal apoptosis and expression of related proteins in spontaneous hypertensive rats with intracerebral hemorrhage. Methods: 30 spontaneously hypertensive rats were used to establish cerebral hemorrhage models by autologous blood injection. They were randomly divided into anesthesia group A and anesthesia group B with 15 rats in each group. Rats in group A were given intravenous inhalation combined with anesthesia, while rats in group B were given target controlled intravenous anesthesia with propofol combined with sufentanil. After the anesthesia took effect, the rats in both groups were injected with autologous blood to build cerebral hemorrhage models. The neurobehavioral scores and brain water content of both groups of rats were observed and compared at 6h, 12h, 24h, 48h and 72h after anesthesia modeling. TUNEL method was used to detect the apoptosis of brain tissue at different time points. The expression of Bax, Bcl-2, caspase-3 and other apoptosis related proteins in brain tissue around intracerebral hemorrhage were detected by immunohistochemistry. The expression of Bax, Bcl-2, caspase-3 and other apoptosis related proteins in brain tissue around intracerebral hemorrhage were detected by RT-PCR and Western blot. Results: Neurobehavioral changes began to appear at 6 hours after intracerebral hemorrhage operation. With the extension of time point, the water content of brain tissue around the hemorrhage area increased significantly, the number of apoptotic cells increased significantly, and the expression of apoptosis related proteins Bax, Bcl-2 and caspase-3 also increased significantly. Compared with anesthesia group A, the nerve of anesthesia group B at 6 h, 12 h, 24 h, 48 h, 72 h after operation was significantly increased. The expression levels of Bax and caspase-3 mRNA and protein were significantly lower than those of group A at the same time point (P<0.05), while the expression of bcl-2 mRNA and protein was significantly higher than that of group A at the same time point (P<0.05). Conclusion: Propofol combined with sufentanil target controlled intravenous anesthesia can reduce the expression of apoptosis related proteins, reduce the apoptosis of nerve cells, reduce the degree of brain level, improve the neurobehavioral score, and play a protective role in the secondary cerebral hemorrhage injury. 2021 Vol. 27 (6): 881-886 [Abstract] ( 134 ) HTML (1 KB)  PDF (2627 KB)  ( 154 ) 887 The Correlation Between Expression of Tim-3 in Peripheral Blood and Chemoradiotherapy Sensitivity of Esophageal Carcinoma ZHAO Chunyan, TANG Jiaying DOI: 10.3969/j.issn.1006-6233.2021.06.02 Objective: To investigate the correlation between the expression of T cell immunoglobulin mucin 3 (Tim-3) and chemoradiotherapy sensitivity of esophageal carcinoma (EC). Methods: Patients who admitted our hospital from January 2017 to December 2019 were diagnosed EC, and their pathological specimens and pathological data were collected. Immunohistochemistry was used to detect the expression of Tim-3 protein in EC tissues and adjacent tissues. Flow cytometry was used to detect the level of Tim-3 in peripheral blood. The relationship between the expression of Tim-3 protein and the pathological parameters of EC was analyzed. The Kaplan Meier survival curve was plotted to further evaluate the relationship between expression of Tim-3 protein and overall survival (OS) and disease-free survival (DFS). The relationship between the prognosis of EC and the expression of Tim-3 protein was analyzed by COX regression analysis. The ROC curve of Tim-3 on the prognosis of EC was plotted, and the area under the curve (AUC) was calculated. Results: After concurrent chemoradiotherapy, patients were divided into sensitive group (36 cases) and resistance group (42 cases). The expression of Tim-3 was high in EC tissues (85.90%), while it was slightly expressed in paracancerous tissues (10.26%). The difference was statistically significant (P<0.05). The abnormal expression of Tim-3 in EC was significantly different in depth of invasion, lymph node metastasis and TNM stage (P<0.05), and patients with high expression of Tim-3 had lower OS and DFS (P<0.05). COX regression analysis showed that high expression of Tim-3 (HR = 4.253, 95% CI 1.464-12.353) was an independent risk factor for chemoradiotherapy sensitivity in EC patients. The area under ROC curve was 0.848, the sensitivity and specificity of prediction were 86.2% and 76.3%, respectively. Conclusion: Tim-3 protein is highly expressed in cancer tissues and serum of EC patients resistant to radiotherapy and chemotherapy, which has a certain correlation with the sensitivity of EC to radiotherapy and chemotherapy, and can be used as a specific marker to predict EC. 2021 Vol. 27 (6): 887-891 [Abstract] ( 118 ) HTML (1 KB)  PDF (1456 KB)  ( 171 ) 892 The Diagnostic Value of PET-CT SUV for Postoperative Recurrence and Metastasis of Colorectal Cancer ZHANG Jiang, CHEN Yaming, WANG Meng, et al DOI: 10.3969/j.issn.1006-6233.2021.06.03 Objective: To explore the changes in the standard uptake value (SUV) of positron emission computed tomography (PET-CT) in patients with colorectal cancer before surgery, and to analyze the diagnostic predictive value of PET-CT SUV for postoperative recurrence and metastasis of colorectal cancer. Methods: A total of 50 patients with colorectal cancer, from November 2017 to August 2020, who met the inclusion criteria in this study were included as observation subjects for retrospective study. The 50 patients underwent whole-body PET-CT examination before surgery, and the highest SUV (SUVmax) in the specific area of colorectal cancer lesions was calculated. In the follow-up the correlation between SUVmax and recurrence or metastasis was observed, and the diagnostic efficacy of SUVmax for colorectal cancer recurrence and metastasis was analyzed. Results: The median follow-up time was 23.5 months, and the follow-up rate was 100%. Of the 50 patients, 24 had local recurrence or metastasis, and 26 patients had no recurrence or metastasis. The preoperative SUVmax of patients with local recurrence or metastasis after operation was (5.3±2.3), and the preoperative SUVmax of patients without recurrence and metastasis after operation was (2.7±0.6). The preoperative SUVmax of the former was significantly higher than the latter, and the difference was statistically significant (t=4.587, P<0.05).When preoperative SUVmax=4.2, the diagnostic sensitivity and specificity of colorectal cancer recurrence and metastasis were 72.0% and 100.0% respectively, and the negative and positive predictive values were 73.0% and 100.0% respectively. Conclusion: The higher the preoperative SUVmax of colorectal cancer patients, the greater the chance of tumor recurrence and metastasis in the near future. The preoperative SUV has important value in predicting the recurrence and metastasis of colorectal cancer patients. 2021 Vol. 27 (6): 892-895 [Abstract] ( 416 ) HTML (1 KB)  PDF (1211 KB)  ( 1145 ) 896 Moxifloxacin on Lung Function Oxygen Metabolism and Serum CRP CK LDH NBC Levels of COPD Patients with Respiratory Failure MA Feifei, SHI Liang DOI: 10.3969/j.issn.1006-6233.2021.06.04 Objective: To explore the effects of moxifloxacin in the treatment of chronic obstructive pulmonary disease (COPD) patients with respiratory failure on lung function, oxygen metabolism, serum C-reactive protein (CRP), creatine kinase (CK), lactate dehydrogenase (LDH), and neutrophils (NBC) level. Methods: 62 COPD patients with respiratory failure admitted between March 2018 and March 2020 were selected as the research objects, and were simply randomly divided into observation group and control group, with 31 cases in each group, using a random number table. Patients in the two groups received conventional treatment. Patients in the control group were treated with aerosol inhalation of salbutamol sulfate, and patients in the observation group were treated with aerosol inhalation of moxifloxacin. The differences in lung function, oxygen metabolism indexes, serum CRP, CK, LDH, and NBC levels before and after treatment were compared between the two groups of patients and the clinical efficacy. Results: Before treatment, there was no significant difference in the levels of FVC, FEV1, FEV1/FVC, CaO2, VO2 Max, ERO2, serum CRP, CK, LDH, and NBC between the two groups of patients (P>0.05); The levels of FVC, FEV1, FEV1/FVC, and CaO2 were higher than before treatment, and the increase in the observation group was greater, while the VO2 Max, ERO2, serum CRP, CK, LDH, and NBC levels of the two groups of patients were lower than before treatment. The degree of reduction in the observation group was greater, and the difference was statistically significant (P<0.05). The difference in efficacy between the two groups of patients was statistically significant (P<0.05). The total effective rate of clinical efficacy in the observation group was 96.77%, which was significantly higher than that of the control group (80.65%). The difference was statistically significant (P<0.05) . Conclusion: Moxifloxacin has a significant effect in the treatment of COPD patients complicated with respiratory failure, which can effectively improve patients' lung function, oxygen metabolism, and improve patients' serum CRP, CK, LDH, and NBC levels. It is worthy of clinical promotion. 2021 Vol. 27 (6): 896-900 [Abstract] ( 162 ) HTML (1 KB)  PDF (1234 KB)  ( 299 ) 901 The Correlation Between Myosin1H Gene Polymorphism and the Susceptibility of Skeletal Mandibular Retrusion in Mongolian LI Xiaohui, CHENG Shuyu, BA Gena, et al DOI: 10.3969/j.issn.1006-6233.2021.06.05 Objective: To analyze the correlation between polymorphism of type I myosin (myosin1H) gene and the susceptibility of skeletal mandibular retrusion (MR) in Mongolian. Methods: A total of 61 patients with skeletal type II malocclusion (mainly on MR) who were treated in stomatology department of the hospital were made the observation group, while another 61 patients with skeletal type I malocclusion were made the control group. All were Mongolian cases in Inner Mongolia. The distribution of Myosin1H gene polymorphisms at rs11611277 and rs3825393 loci was detected by polymerase chain reaction-restriction fragments length polymorphism (PCR-RELP). The correlation between Myosin1H gene polymorphism and the susceptibility of skeletal MR was analyzed. Results: The genotype carrying AG and frequency of A allele in observation group were 60.66% and 38.52%, higher than those in control group (24.59%, 23.77%) (P<0.05). In observation group, SNB angle and Z angle in patients carrying AG genotype at rs3825393 locus wee (81.49±1.73)° and (62.25±4.75)°, lower than those carrying GG genotype [(82.18±1.57)°, (82.16±1.95)°] and AA genotype [(72.14±5.11)° , (73.52±6.34)°] (P<0.05), while ANB angle [(5.91±0.75)°] was higher than those carrying GG genotype [(4.21±1.45)°] and AA genotype [(4.19±0.65)°] (P<0.05). Taking GG genotype as control group, carrying AG genotype of Myosin1H gene at rs3825393 could increase the susceptibility to MR by 2.571 times (P<0.05). Conclusion: G→A mutation of Myosin1H gene at rs3825393 locus is related to the susceptibility of MR in Mongolian. The risk of susceptibility to MR is higher in patients with AG genotype at the locus. 2021 Vol. 27 (6): 901-905 [Abstract] ( 89 ) HTML (1 KB)  PDF (1239 KB)  ( 155 ) 906 Diagnostic Value of Combined Detection of Peripheral Blood Smear Bone Marrow Cell Morphology and Bone Marrow Biopsy for Myelodysplastic Syndrome ZHU Xiaohua, WANG Jiancheng, CHENG Yan, et al DOI: 10.3969/j.issn.1006-6233.2021.06.06 Objective: To investigate the diagnostic value of combined detection of peripheral blood smear, bone marrow cell morphology and bone marrow biopsy for myelodysplastic syndrome (MDS), aiming at providing reference for early diagnosis and treatment of MDS. Methods: 108 patients with suspected MDS admitted to the hospital from January 2016 to January 2020 were selected as subjects. All patients underwent peripheral blood smear, detection of bone marrow cell morphology and bone marrow biopsy. With follow-up data as the golden standard, the value of combined detection of peripheral blood smear, bone marrow cell morphology and bone marrow biopsy for diagnosis and classification of MDS was evaluated. Results: The efficiency (Kappa value) of combined detection of peripheral blood smear, bone marrow cell morphology and bone marrow biopsy in the diagnosis of MDS was higher than that of single detection. The sensitivity was significantly higher than that of single detection(P<0.05). With follow-up data as the golden standard, the accuracy of combined detection of peripheral blood smear, bone marrow cell morphology and bone marrow biopsy for classification of MDS was 84.62%(66/78). Conclusion: The combination detection of peripheral blood smear, bone marrow cell morphology and bone marrow biopsy can effectively improve the diagnostic sensitivity and accuracy for MDS. The accuracy of combined detection is also high in the classification of MDS. It is expected to provide reference for selection of treatment plan for MDS and prognosis evaluation. 2021 Vol. 27 (6): 906-909 [Abstract] ( 111 ) HTML (1 KB)  PDF (1222 KB)  ( 251 ) 910 Study on the Overexpression of Fragile X-Related Gene 1 in Meningioma Tissue to Promote the Growth and Angiogenesis of Meningioma Cells CAO Jie, ZHANG Jie, MENG Facai, et al DOI: 10.3969/j.issn.1006-6233.2021.06.07 Objective: To investigate the expression of RNA-binding gene fragile X-related protein 1 (FXR1) in human meningiomas and its effect on the growth and angiogenesis of meningiomas. Methods: Collect the tumor tissue and adjacent tissue specimens of 24 meningiomas in our hospital, and detect the expression of FXR1 by immunohistochemical staining. Isolate and culture human meningioma cells, and divide the cultured cells into blank control group, pcDNA3.1-NC group and pcDNA3.1-FXR1 group. Transfect the pcDNA3.1-FXR1 plasmid vector and the pcDNA3.1 empty plasmid vector to meningiomas by lipofection; Real-time fluorescent quantitative PCR and Western blot detection of FXR1 mRNA and protein expression levels in cells were pweformed; CCK-8 experiment was conducted to detect cell proliferation activity; cell clone formation test was conducted to detect cell colony forming ability; Western blot was conducted to detect VEGF and EDN-1 protein expression levels; flow cytometry was conducted to detect the positive cell expression of the markers CD31 and CD34 of vascular endothelial cells; in vitro tubule formation test was conducted to detect the tube formation of HUVECs. Results: The positive expression of FXR1 in meningioma tissue was significantly higher than that in adjacent tissues (P<0.05). Compared with the blank control group and the pcDNA3.1-NC group, the relative expression of FXR1 mRNA and protein in the cells of the pcDNA3.1-FXR1 group were significantly increased (P<0.05), cell proliferation activity increased significantly after 48, 72 and 96 hours of transfection (P<0.05), the number of cell clone formation increased significantly (P<0.05), VEGF and EDN-1 protein expression levels increased significantly (P<0.05), the number of positive cells marked by CD34 and CD31 increased significantly (P<0.05), at the same time, the number of lumens formed increased significantly. Conclusion: FXR1 is highly expressed in human meningiomas. Overexpression of FXR1 can promote meningioma cell growth and angiogenesis. 2021 Vol. 27 (6): 910-915 [Abstract] ( 76 ) HTML (1 KB)  PDF (2403 KB)  ( 179 ) 916 Effects of T Cell Immunoglobulin and Mucin Domain Protein-3 on T Cells in Patients with Type 2 Diabetes GU Yinye, ZHANG Jue, SHI Lei DOI: 10.3969/j.issn.1006-6233.2021.06.08 Objective: To investigate the effect of T immunoglobulin and mucin domain protein-3 on T cells in type 2 diabetes mellitus. Methods: This study selected 72 patients with type 2 diabetes from January 2017 to December 2019 and 55 healthy controls as the control group to compare the expression of TIM-3 in T cells. The relative expression of cytokines was compared between the two groups. To further compare the relative expression of cytokines and transcription factors stimulated by anti TIM-3 antibody on T cells of diabetic patients. Results: The contents of CD4+T and CD8+T cells in diabetic group were significantly higher than those in control group (P<0.05); diabetic group had lower INF-γ、IL-4、IL-17、IL-22 content than control group. The IL-10、IL-35 content of diabetic group was higher than that of control group (P<0.05). The content of TNF-α、INF-γ in diabetic group was lower than that in control group (P<0.05). The INF-γ、IL-17、IL-22 content of diabetic patients stimulated by anti-antibody TIM-3 was significantly higher than that of non-antibody stimulated diabetic patients. The IL-35 content of diabetic patients after anti-antibody stimulation was significantly lower than that of non-antibody stimulation diabetic patients (P<0.05). The TNF-α、INF-γ content of diabetic patients after anti-antibody stimulation was higher than that of non-antibody stimulation diabetic patients (P<0.05). Conclusion: The expression of T cell surface mucin domain protein-3 is increased in diabetic patients. The content will rise, and may be involved in the cellular regulatory function T type 2 diabetes patients. 2021 Vol. 27 (6): 916-919 [Abstract] ( 108 ) HTML (1 KB)  PDF (1226 KB)  ( 230 ) 920 Diagnostic Value of Antithrombin-III Coagulation Index and D-Dimer in Different Degrees of Pregnancy-Induced Hypertension CAI Congying DOI: 10.3969/j.issn.1006-6233.2021.06.09 Objective: To study the predictive value of antithrombin-III (AT-Ⅲ) coagulation index and D-dimer (D-D) in different degrees of pregnancy-induced hypertension. Methods: A total of 108 patients with pregnancy-induced hypertension admitted to our hospital from December 2017 to December 2019 were retrospectively analyzed. They were sub-grouped as pregnancy-induced hypertension group(42 cases), mild PE group (36 cases) and severe PE group (30cases) according to the severity of the disease. Another selection of normal pregnancy women during the same period were made the normal group (48 cases). The differences of four coagulation, AT-Ⅲ and D-D between each group were compared, and the correlation between each index and disease severity was analyzed. The working characteristic curve (ROC curve) was used to analyze the predictive value of the above indexes on the severity of the disease. Results: PT、APTT、TT and AT-Ⅲ levels of normal group> pregnancy-induced hypertension grouP> mild PE group and severe PE group, the values were statistically significant (Pall<0.05);The FIB、D-D level of normal grouP< pregnancy-induced hypertension grouP< mild PE group and severe PE group, the values were statistically significant (Pall<0.05).Spearman correlation analysis shows that PT, APTT, TT, and the AT-Ⅲ were significant negative correlated with PE (r= -0.790, -0.680,- 0.826, -0.597, Pall<0.05), FIB and D-D were positively correlated with PE (r =0.690, 0.780, Pall<0.05).ROC curve analysis showed that PT, APTT, TT, FIB, the AT-Ⅲ and D-D to predict severe PE AUC were 0.934, 0.930, 0.912, 0.874, 0.805, 0.867, predictive value is better . Conclusion: The coagulation condition of patients with different degrees of pregnancy-induced hypertension can be better reflected by four coagulations, AT-Ⅲ and D-D, and the predictive value of severe PE is high. By monitoring the above indexes, the severity of the disease can be detected as soon as possible, and the symptomatic treatment can be given. 2021 Vol. 27 (6): 920-923 [Abstract] ( 98 ) HTML (1 KB)  PDF (1429 KB)  ( 224 ) 924 Effects of Amniotic Membrane Transplantation and Conjunctival Autograft Transplantation on Visual Quality Corneal Refractive Power and Tear Film Function of Patients Undergoing Pterygium Surgery HUANG Lijuan, LIN Xuesong DOI: 10.3969/j.issn.1006-6233.2021.06.010 Objective: To explore the effects of amniotic membrane transplantation and conjunctival autograft transplantation on visual quality, corneal refractive power and tear film function of patients undergoing pterygium surgery. Methods: A prospective study was conducted among 220 patients undergoing pterygium surgery at the hospital between June 2018 and November 2019. They were randomly divided into control group and experimental group by random number table method, 110 cases in each group. The control group was treated with amniotic membrane transplantation after pterygium surgery, and the experimental group was treated with conjunctival autograft transplantation. Therapeutic effects of the 2 groups were compared. Visual quality, corneal refractive power and tear film function of the 2 groups were observed before and after treatment. Meanwhile, the incidence of complications was compared between the 2 groups. Results: There were no significant differences in the total response rate and recurrence rate between the 2 groups (P>0.05). Compared with the same group before treatment, MTF, SR, SIT and BUT of both groups were significantly increased. Besides, the above indexes of experimental group were significantly higher than those of the control group (P<0.05). However, TF-OSI and corneal refractive power were significantly reduced, which were significantly lower in the experimental group than the control group (P<0.05). The recurrence rate and the incidence of complications in experimental group were slightly lower than those in the control group (P>0.05). Conclusion: Clinical effects of conjunctival autograft transplantation and amniotic membrane transplantation are similar in patients undergoing pterygium surgery. However, the former is more conducive to the improvement of visual quality, corneal refractive power and tear film function. Besides, the risk of complications is lower. 2021 Vol. 27 (6): 924-929 [Abstract] ( 81 ) HTML (1 KB)  PDF (1243 KB)  ( 296 ) 930 Clinical Value of Combined Examination of Serum β-HCG PCT and CRP and Secretion GBS in Predicting Chorioamnionitis and Neonatal Infection in Pregnant Women with Premature Rupture of Membranes GAO Yanjie, GONG Chuntao, WANG Haixia, et al DOI: 10.3969/j.issn.1006-6233.2021.06.011 Objective: To investigate the clinical value of combined examination of serum β-chorionic gonadotropin (β-HCG), procalcitonin (PCT) and C-reactive protein (CRP) and secretion group B streptococcus (GBS) in predicting chorioamnionitis and neonatal infection in pregnant women with premature rupture of membranes (PROM). Methods: From September 2019 to September 2020, 300 pregnant women were selected, including 100 cases with PROM of term (tPROM group), 100 cases with preterm PROM (PPROM), and 100 pregnant women without PROM undergoing termination of pregnancy by cesarean section (control group). Maternal serum β-HCG, PCT and CRP levels and GBS positive rate, neonatal cord blood PCT and CRP were detected. Results: Serum β-HCG, PCT and CRP levels and GBS positive rate in the PPROM group were higher than those in the tPROM group and control group (P<0.05). Besides, serum β-HCG, PCT and CRP levels and GBS positive rate in the chorioamnionitis group were higher than those in the non-chorioamnionitis group (P<0.05).ROC curve analysis showed that the sensitivity and AUC of serum β-HCG, PCT and CRP levels in tandem detection of pregnant women with premature rupture of membranes complicated with chorionic amnitis were higher than those of single detection(P<0.05). Cord blood PCT and CRP levels in sepsis group were higher than those in the neonatal pneumonia group, non-infection group and control group (P<0.05). Conclusion: Pregnant women with PROM have elevated serum β-HCG, PCT and CRP levels and GBS positive rate. Combination of the four has higher value in predicting chorioamnionitis. Cord blood PCT and CRP levels can help early diagnosis of neonatal infection. 2021 Vol. 27 (6): 930-934 [Abstract] ( 140 ) HTML (1 KB)  PDF (1359 KB)  ( 219 ) 935 Research on the Correlation Between Serum BNP γ-GT Levels and Neural Prognosis in Asphyxia Neonates ZHANG Wei, YANG Ling, ZHONG Lihua DOI: 10.3969/j.issn.1006-6233.2021.06.012 Objective: To study the correlation between serum brain natriuretic peptide (BNP), γ-glutamyl transpeptidase (γ-GT) levels and neural prognosis in asphyxia neonates. Methods: A total of 128 asphyxia neonates who were admitted to the hospital from February 2017 to June 2019 were enrolled, including 76 cases in mild group and 52 cases in severe group. Another 30 healthy neonates were enrolled as control group. The levels of serum BNP and γ-GT, and scores of neonatal behavioral neurological assessment (NBNA) were compared among the three groups. The efficiency of serum BNP and γ-GT levels for distinguishing mild asphyxia from severe asphyxia was analyzed by ROC curves. The correlation between expression level of BNP and γ-GT and NBNA score was analyzed by Pearson method. Results: There were significant differences in levels of BNP and γ-GT among the three groups (P<0.05). The levels of BNP and γ-GT were the highest in severe group, followed by mild groups and control group (P<0.05). The area under the curve (AUC) values for BNP and γ-GT to identify mild and severe asphyxia were 0.885 (95%CI: 0.827-0.943, P<0.001) and 0.847 (95%CI: 0.777-0.917, P<0.001), respectively. There were significant differences in NBNA scores of newborns with different degrees of asphyxia compared with control group (P<0.05).There were significant differences in NBNA scores among the three groups at different times, and the NBNA scores gradually increased, whose increase was more significant in severe group (P<0.05). The expression levels of BNP and γ-GT were negatively correlated with NBNA scores on the first day and 7th day in severe group [(r=-0.318, r=-0.352, P<0.05), (r=-0.303, r=-0.380, P<0.05)]. Conclusion: Serum BNP and γ-GT can effectively distinguish the severity of neonatal asphyxia. The expression levels of BNP and γ-GT on the first day and 7th day are correlated with neural prognosis in severe asphyxia neonates. The more severe the asphyxia, the higher the expression levels of BNP and γ-GT, and the lower the NBNA score. 2021 Vol. 27 (6): 935-938 [Abstract] ( 103 ) HTML (1 KB)  PDF (1617 KB)  ( 252 ) 939 An Analysis of the Correlation Between the Levels of Peripheral Blood Ghrelin PTX3 TNF-α IL-6 and Myocardial Injury in Patients with Obstructive Sleep Apnea Syndrome YANG Yanqiong, LUO Mei, LEI Qing, et al DOI: 10.3969/j.issn.1006-6233.2021.06.013 Objective: To study the correlation between peripheral blood ghrelin, PTX3, TNF-α, IL-6 levels and myocardial injury in patients with obstructive sleep apnea syndrome. Methods: A prospective selection of 88 patients with OSAHS who were diagnosed and treated in our hospital from June 2018 to June 2020 were divided into mild group (5<AHI≤15) with 33 cases according to the apnea index detected by polysomnography. There were 31 cases in the moderate group (15<AHI≤30), 24 cases in the severe group (AHI>30), and 30 healthy persons (AHI≤5) in the same period in the healthy group for control. Peripheral blood ghrelin, PTX3, TNF-α, IL-6 levels and myocardial injury markers NT-proBNP, HFABP, cTnI levels were detected and compared in each group. Pearson test was used to analyze the correlation of the above indicators. Results: The levels of ghrelin, PTX3, TNF-α, and IL-6 in each group of OSAHS patients were significantly higher than those in the healthy group, and the levels of ghrelin, PTX3, TNF-α, and IL-6 followed the order of mild, moderate, and severe increasingly (P<0.001). The levels of NT-proBNP, HFABP, and cTnI in each group of OSAHS patients were significantly higher than those in the healthy group, and the levels of NT-proBNP, HFABP, and cTnI increased in the order of the mild group, moderate group, and severe group (P<0.001). OSAHS patients' ghrelin level was negatively correlated with NT-proBNP, HFABP, cTnI levels (r=-0.384, r=-0.653, r=-0.498; P<0.001); OSAHS patients' PTX3 level was correlated with NT-proBNP, HFABP, cTnI. The level was positively correlated (r=0.892, r=0.740, r=0.823; P<0.001); the level of TNF-α in OSAHS patients was positively correlated with the levels of NT-proBNP, HFABP, and cTnI (r=0.680, r=0.657, r =0.760; P<0.001) IL-6 levels in OSAHS patients were positively correlated with NT-proBNP, HFABP, and cTnI levels (r=0.674, r=0.666, r=0.778; P<0.001). Conclusion: The levels of ghrelin, PTX3, TNF-α, and IL-6 are importantly related to myocardial damage, which may be caused by the inflammatory reaction caused by impaired breathing and intermittent hypoxia, which may damage the cardiovascular system. Therefore, attention should be paid in the treatment of OSAHS to monitoring the level of inflammatory factors. 2021 Vol. 27 (6): 939-942 [Abstract] ( 91 ) HTML (1 KB)  PDF (1227 KB)  ( 177 ) 943 Detection of Th1/Th2 Cytokines Secreted by T Lymphocyte in Peripheral Blood in Patients with Scar Uterus and Its Significance AN Xin, et al DOI: 10.3969/j.issn.1006-6233.2021.06.014 Objective: The contents of Th1/Th2 cytokines secreted by T lymphocyte in peripheral blood in patients with scar uterus were detected in order to reveal the possible immune mechanism of uterus scar. Methods: A total of 108 patients with scar uterus were made the study group, and another 126 patients without scar uterus were made the control group. The contents of Th1/Th2 cytokines secreted by T lymphocyte in peripheral blood in both groups were detected. Results: The contents of IFN-γ and IL-12 secreted by lymphocytes in peripheral blood in experimental group were higher than those in control group, and the differences were statistically significant. But compared to the control group, the contents of IL-4 and IL-10 secreted by lymphocytes in peripheral blood in the study group were seen to be with no statistical difference. Conclusion: Chances are that the formation of uterus with scar is related to the increase of cellular immunity mediated by Th1 cells. 2021 Vol. 27 (6): 943-945 [Abstract] ( 103 ) HTML (1 KB)  PDF (1211 KB)  ( 198 ) 946 Changes and Significance of Serum ET-1 PGE2 and PGF2α Levels in Patients Before and After Flexible Ureteroscopic Lithotripsy DUAN Tao, LENG Guoxiong, ZHANG Jiuwu, et al DOI: 10.3969/j.issn.1006-6233.2021.06.015 Objective: To explore the changes and significance of serum endothelin-1 (ET-1), prostaglandin E2 (PGE2) and prostaglandin F2α (PGF2α) levels in patients before and after flexible ureteroscopic lithotripsy (FURL). Methods: A total of 268 patients with urinary calculi who were treated in the hospital from February 2017 to December 2019 were enrolled as the research subjects. All patients underwent FURL. The occurrence of systemic inflammatory response syndrome (SIRS) within 1 week after surgery, as well as levels of serum ET-1, PGE2 and PGF2α before and after surgery were observed. The relationship between serum ET-1, PGE2, PGF2α levels and the occurrence of SIRS was analyzed by univariate, multivariate and ROC curves analysis. Results: Among the 268 patients, there were 24 cases (8.96%) with SIRS (SIRS group) and 244 cases (91.04%) without SIRS (non-SIRS group) within 1 week after surgery. The difference of serum ET-1, PGE2, PGF2α before and after operation in SIRS group was higher than that in non-SIRS group (P<0.05). The results of univariate analysis showed that there were significant differences in gender, diabetes, operation time, postoperative levels of serum ET-1, PGE2 and PGF2α, and urinary tract infection between the two groups (P<0.05). The results of multivariate regression analysis showed that operation time not shorter than 120 min, urinary tract infection, postoperative ET-1 level not lower than 81.33 ng/L, PGE2 not lower than 254.23 pg/mL and PGF2α not lower than 117.56 ng/mL were independent predictors of SIRS. The results of ROC curve analysis showed that the area under the ROC curve (AUC) of serum ET-1 combined with PGE2 and PGF2α for predicting SIRS was higher than that of them alone (P<0.05). Conclusion: The levels of serum ET-1, PGE2 and PGF2α are increased in patients after FURL, which are highly expressed in patients with SIRS. The combined detection of three indexes is of application value in clinically predicting SIRS. 2021 Vol. 27 (6): 946-951 [Abstract] ( 103 ) HTML (1 KB)  PDF (1424 KB)  ( 167 ) 952 Expression of MiR-497 and CCNE1 in Non-Small Cell Lung Cancer and Its Relationship with Prognosis DING Lingzhi, LUO Xiangjun, CHEN Weiwei, et al DOI: 10.3969/j.issn.1006-6233.2021.06.016 Objective: To investigate the expressive characteristics of miR-497 and cyclin E1 (CCNE1) in non-small cell lung cancer (NSCLC) tissues, and to analyze the relationship between miR-497, CCNE1 and clinicopathological features and prognosis of patients. Methods: A total of 102 cases of NSCLC admitted to our hospital from February 2016 to December 2017 were selected. Surgical resection of cancerous tissue (NSCLC group) and paracancerous tissue (≥5 cm from the edge of tumor tissue) (paracancerous group) were selected. Real-time quantitative PCR (qRT-PCR) was used to detect the expression of miR-497 and CCNE1, and Pearson correlation was used to analyze the correlation between miR-497 and CCNE1. Postoperative follow-up was maintained, and Kaplan-Meier method was used to analyze the difference in survival rates among patients with different miR-497 and CCNE1 expression, and Cox proportional risk model was used to analyze the related factors affecting the prognosis of NSCLC patients. Results: The expression of miR-497 in NSCLC group was lower than that in paracancerous group (P<0.001), and the expression of CCNE1 was higher than that in paracancerous group (P<0.001). The expression of miR-497 and CCNE1 was correlated with tumor diameter, degree of differentiation and TNM stage (P<0.001). Pearson correlation analysis showed that miR-497 expression was negatively correlated with CCNE1 (r=-0.539,P<0.001). Kaplan-Meier survival curve analysis showed that the PFS and OS survival rates in the group with low miR-497 expression were lower than those in the group with high miR-497 expression (P<0.05), and the PFS and OS survival rates in the group with high CCNE1 expression were lower than those in the group with low CCNE1 expression (P<0.05). Cox proportional hazards regression analysis showed that TNM stage Ⅲ, miR - 497<0.56, CCNE1 acuity 1.05 were risk factors for poor prognosis of NSCLC patients (P<0.01). Conclusion: The expression of miR-497 is down-regulated and the expression of CCNE1 is up-regulated in NSCLC tissues. MiR-497 may be involved in malignant biological behavior and poor prognosis of NSCLC by negatively regulating the expression of CCNE1. 2021 Vol. 27 (6): 952-957 [Abstract] ( 114 ) HTML (1 KB)  PDF (1526 KB)  ( 165 ) 958 Relationship between the Levels of Serum CK18 and FGF-21 with Bleeding from Esophageal Varices and Liver Function Classification in Patients with Liver Cirrhosis Ascites ZHANG Shunli, et al DOI: 10.3969/j.issn.1006-6233.2021.06.017 Objective: To analyze the relationship of the expression levels of serum cytokeratin 18 (CK18) and fibroblast growth factor 21 (FGF-21) with bleeding from esophageal varices (EV) and liver function classification in patients with liver cirrhosis ascites. Methods: 245 patients with liver cirrhosis ascites were selected and their serum CK18 and FGF-21 levels were tested. Serum CK18 and FGF-21 levels of patients with different Chid-Pugh grades of liver function were compared, and correlation analysis was carried out. According to the presence or absence of bleeding from EV, the patients were divided into bleeding group and non-bleeding group. Factors affecting bleeding from EV were analyzed. Results: CK18 levels of patients with grade A, grade B, and grade C liver function increased in turn (P<0.05), while FGF-21 levels of patients with grade A, grade B, and grade C liver function decreased in turn (P<0.05). The grade of liver function was positively correlated with CK18 (P<0.05), and negatively correlated with FGF-21 (P<0.05). There were statistically significant differences between the bleeding group and the non-bleeding group in terms of EV degree, Chid-Pugh classification of liver function, CK18 and FGF-21 expression levels (P<0.05). Logistic analysis showed that Chid-Pugh classification of liver function and CK18 were risk factors for bleeding from EV (P<0.05), while FGF-21 was a protective factor (P<0.05). Conclusion: The expression levels of serum CK18 and FGF-21 in patients with liver cirrhosis ascites are closely related to bleeding from EV and liver function classification. 2021 Vol. 27 (6): 958-962 [Abstract] ( 133 ) HTML (1 KB)  PDF (1232 KB)  ( 218 ) 963 The Expression of ERCC1 and SLC7A11 in Esophageal Squamous Cell Carcinoma and its Relationship with the Efficacy of Neoadjuvant Chemotherapy LUI Jianwei, XU Shizong, Li Li, et al DOI: 10.3969/j.issn.1006-6233.2021.06.018 Objective: To Observe the changes of ERCC1 and SLC7A11 expression in esophageal cancer tissue, and to explore the role of ERCC1 and SLC7A11 in esophageal cancer chemotherapy. Methods: The expression levels of ERCC1 and SLC7A11 in 92 cases of esophageal cancer tissue (experimental group) and 36 cases of normal esophageal mucosa tissue (control group) were detected by SP immunohistochemical method, and the relationship between the relative transcript levels and clinicopathological characteristics of patients with esophageal cancer was analyzed. Results: The positive rates of ERCC1 and SLC7A11 expression in esophageal cancer group were higher than those in control group (P<0.01). The high expression of ERCC1 was correlated with the clinical stages, differentiation degrees and lymph node metastasis of esophageal cancer (P<0.05), but not with gender and age (P>0.05).The high expression of SLC7A11 was correlated with the clinical stages, lymph node metastasis, and differentiation degrees of esophageal cancer (P<0.05), but not with gender and age (P>0.05).Pearson correlation analysis showed that ERCC1 expression level was positively correlated with SLC7A11 expression level.Kaplan-Meier analysis showed that the recurrence rate of esophageal cancer patients with ERCC1 (+)/SLC7A11 (+) high expression was also higher than that of patients with negative ERCC1/ SLC7A11 expression at 3 years after treatment. The difference was statistically significant (P<0.05). The overall survival rate at 3 years was lower than that of patients with negative expression (P < 0.05).Among 81 patients receiving neoadjuvant chemotherapy, there were 59 patients in the sensitive group and 22 patients in the drug resistant group. The positive expression rate of ERCC1 was significantly different between the two groups (P<0.01). The positive expression rate of SLC7A11 was significantly different between the two groups (P<0.05). Conclusion: The expression levels of ERCC1 and SLC7A1,to some extent, are of a certain guiding effect on preoperative neoadjuvant chemotherapy in patients with esophageal cancer, and the efficacy of neoadjuvant chemotherapy in patients with ERCC1 (+)/SLC7A11 (+) high expression is poor. 2021 Vol. 27 (6): 963-967 [Abstract] ( 75 ) HTML (1 KB)  PDF (1519 KB)  ( 289 ) 968 Changes of Levels of Serum Creatinine Urea Nitrogen and B-Natriuretic Peptide in Perioperative Period of Elderly Patients with Femoral Intertrochanteric Fractures and the Clinical Significance JIANG Mingju, HU Yong DOI: 10.3969/j.issn.1006-6233.2021.06.019 Objective: To explore changes of levels of serum creatinine (serum creatinine, Scr), blood urea nitrogen (blood urea nitrogen, BUN) and B-type natriuretic peptide (B-type natriuretic peptide, BNP) in perioperative period of elderly patients with femoral intertrochanteric fractures, and analyze the risk factors for poor prognosis of patients after operation. Methods:The clinical data of 147 elderly patients with intertrochanteric fractures who underwent surgical treatment in the hospital from January 2017 to June 2020 were retrospectively analyzed. According to the occurrence of adverse events, patients were divided into good prognosis group (n=122) and poor prognosis group (n=25). The general clinical data and changes in levels of serum Scr, BUN and BNP at different time points (before surgery, at 12h, 24h, 48h and 72h after surgery) were compared between the two groups. The independent risk factors of poor prognosis were analyzed by multivariate logistic regression analysis. Results:Older age and longer interval from injury to operation are observed in poor prognosis group than those in good prognosis group (P<0.05), and proportion of patients with ASA grading at grade III-IV, preoperative abnormal renal function and difference value of perioperative fluid intake and output not lower than 500mL was higher than that in good prognosis group (P<0.05). There were no significant differences in gender, history of underlying diseases, operation time, hospitalization time and anesthesia method between the two groups (P>0.05). After surgery, levels of serum Scr and BNP were increased and then decreased, and level of serum BUN was gradually increased in poor prognosis group. The levels of serum Scr, BUN and BNP were increased and then decreased in good prognosis group. The levels of serum Scr, BUN and BNP in the two groups showed statistically significant differences in terms of inter-group effect, time effect, and interaction effect (P<0.05). At 48h and 72h after operation, the poor prognosis group had significantly higher serum BUN levels than the good prognosis group (P<0.05). At 12h, 24h, 48h and 72h after operation, serum BNP and Scr levels in the poor prognosis group were higher than those in the good prognosis group (P<0.05).Logistic regression analysis showed that age, ASA grading at grade III-IV, difference value of perioperative fluid intake and output not lower than 500mL, levels of serum Scr, BUN and BNP levels at 72h after surgery were influencing factors of poor prognosis in elderly patients with intertrochanteric fractures (P<0.05). Conclusion:Influencing factors for postoperative poor prognosis in elderly patients with intertrochanteric fractures include age, ASA grading at grade III-IV, difference value of perioperative fluid intake and output not lower than 500mL, levels of serum Scr, BUN and BNP levels at 72h after surgery. The real-time monitoring on levels of serum Scr, BUN and BNP levels at 72h after surgery, and taking effective intervention measures can improve their prognosis. 2021 Vol. 27 (6): 968-974 [Abstract] ( 119 ) HTML (1 KB)  PDF (2482 KB)  ( 249 ) 975 An Analysis of the Correlation Between Plasma Circulation MiR-126 MiR-155 and In-Stent Restenosis in Elderly Patients with Coronary Heart Disease DU Yue, LI Sha, XIAO Ming, et al DOI: 10.3969/j.issn.1006-6233.2021.06.020 Objective: To detect the expressions of plasma circulation microRNA-126 (miR-126) and microRNA-155 (miR-155) in elderly patients with coronary heart disease, and to explore the correlation between their expression levels and the occurrence of in-stent restenosis (ISR) after percutaneous coronary intervention (PCI). Methods: From August 2017 to September 2019, 135 elderly patients with coronary heart disease confirmed by coronary angiography and percutaneous coronary intervention (PCI) in our hospital were selected as the study objects, coronary angiography was performed 1 year after operation, and the patients were divided into restenosis group (n = 39) and non restenosis group (96). The expression levels of miR-126 and miR-155 were detected by real-time fluorescence quantitative PCR (qRT-PCR); the diagnostic value of plasma circulation miR-126 and miR-155 expressions in elderly patients with coronary heart disease who had ISR after PCI was evaluated by receiver operating characteristic curve (ROC); and Logistic regression analysis was used to analyze the influencing factors of ISR in elderly patients with coronary heart disease after PCI. Results: The expression levels of plasma miR-126 and miR-155 in the restenosis group were significantly lower than those in the non-restenosis group (P<0.05). ROC results showed that AUC of plasma miR-126 and miR-155 was 0.843 and 0.708, respectively, and the cutoff value was 3.158 and 1.424, respectively, at this time, the corresponding sensitivity was 74.0% and 59.4%, and the specificity was 82.1% and 76.9%, respectively; the AUC of ISR after PCI in elderly patients with coronary heart disease detected by plasma circulation miR-126 combined with miR-155 was 0.864, and the corresponding sensitivity and specificity were 79.2% and 84.6%, respectively. Logistic analysis showed that low expressions of miR-126 and miR-155 in plasma circulation were independent risk factors for ISR in elderly patients with coronary heart disease after PCI. Conclusion: The expressions of plasma circulation miR-126 and miR-155 significantly decreased among elderly patients with coronary heart disease who had ISR after PCI and they participate in the occurrence and development of ISR in elderly patients with coronary heart disease after PCI, therefore, it is suggested that miR-126 and miR-155 in plasma circulation may be potential biological indicators for diagnosis and disease assessment of elderly patients with coronary heart disease who had ISR after PCI. 2021 Vol. 27 (6): 975-979 [Abstract] ( 114 ) HTML (1 KB)  PDF (1270 KB)  ( 164 ) 980 Observation of Inflammatory Response and Bone Metabolism in the Treatment of Thoracolumbar Fractures with Traditional Posterior Median Approach, Paraspinal Space Approach and Minimally Invasive Percutaneous Approach HOU Jiangye, ZHANG Ning, CAI Fei, et al DOI: 10.3969/j.issn.1006-6233.2021.06.021 Objective: To explore the clinical effects of traditional posterior median approach, paraspinal muscle approach and minimally invasive percutaneous approach in the treatment of thoracolumbar fractures. Methods: The selected study subjects were 150 cases of thoracolumbar fractures from January 2017 to December 2019, and they were divided into group A (the paraspinal muscle space approach group received surgical treatment, n=60), Group B (surgery with minimally invasive percutaneous approach, n=30), and group C (surgery with traditional posterior median approach, n=60) according to the random number table. The study compared the three groups of TNF-α, MCP-1, HMGB- 1. CRP, IL-1β, OC, OPG, PICP, PINP, TRACPsb, RANKL, β-CTx, NTX indicators, as well as evaluation of operation time, intraoperative blood loss, hospital stay, and incision length. Results: Repeated measures analysis of variance showed significant difference between the three groups of TNF-α, MCP-1, HMGB-1, CRP, IL-1β, OC, OPG, PCP, PINP, TRACPsb, RANKL, β-CTx, NTX time point. (P<0.05). One-way variance showed that there was no significant difference between the three groups of TNF-α, MCP-1, HMGB-1, CRP, IL-1β, OC, OPG, PICP, PINP, TRACPsb, RANKL, β-CTx, NTX before surgery ( P>0.05); 48h after operation, TNF-α, MCP-1, HMGB-1, CRP, IL-1β, TRACPsb, RANKL, β-CTx, NTX in group A were lower than those in groups B and C, while OC and OPG , PICP and PINP were higher than those in groups B and C , but lower than those of B and C groups (P<0.05). The operation time of group A was shorter than that of group B and C (P<0.05); the blood loss of group A was lower than group C (P<0.05); the blood loss of group A was not significantly different from group B (P>0.05). Comparison of the length of hospital stay of the three groups showed no significant difference (P>0.05). Conclusion: Comparison of the three surgical approaches revealed the paraspinal space approach is more effective, that is, the operation time is short and the inflammation is small. 2021 Vol. 27 (6): 980-985 [Abstract] ( 115 ) HTML (1 KB)  PDF (1242 KB)  ( 133 ) 986 Effects of Endoscopic Full-Thickness Resection Endoscopic Submucosal Dissection and Laparoscopic Surgery on Resection Rate and Complications of Gastric Lamina Propria Stromal Tumor HUANG Kehua, YUAN Shengchun, ZHANG Zhen DOI: 10.3969/j.issn.1006-6233.2021.06.022 Objective: To explore the effects of endoscopic full-thickness resection (EFR), endoscopic submucosal dissection (ESE) and laparoscopic surgery on resection rate and complications of gastric lamina propria stromal tumor. Methods: The clinical data of 186 patients with gastric muscularis propria stromal tumor were retrospectively analyzed. 62 patients in the laparoscopic group were treated with laparoscopic surgery, 61 patients in the EFR group were treated with endoscopic full-thickness resection, and 63 patients in the ESE group were treated with endoscopic submucosal excavation treatment, and the study compared the operation time of the three groups, the average body temperature of 3 days after the operation, the total number of white blood cells on the day after the operation, the postoperative ventilation time, the hospitalization cost, the hospitalization time, the incidence of complications, and the resection rate. Results: There was no significant difference in operation time, total white blood cell count, average temperature of 3 days after operation, resection rate and complications among the three groups (P>0.05). The postoperative ventilation time and hospitalization time of EFR group and ESE group were shorter than those of laparoscopic group, and the hospitalization cost was less than that of laparoscopic group (P<0.05). The hospitalization cost of EFR group was shorter than that of ESE group (P<0.05). Conclusion: Laparoscopic surgery, ESE, EFR surgery can completely resect the lesion tissue of patients with gastric muscularis propria stromal tumor, but compared with laparoscopic surgery, endoscopic surgery has shorter hospitalization time and lower hospitalization cost, but endoscopic surgery is more complicated than laparoscopic surgery, so it is still necessary to choose reasonable surgical methods according to the actual situation of patients. 2021 Vol. 27 (6): 986-989 [Abstract] ( 115 ) HTML (1 KB)  PDF (1222 KB)  ( 301 ) 990 An Observation of Curative Effect of Minimally Invasive Trepanation and Drainage Through the Temporal Approach and the Frontal Approach in the Treatment of Hypertensive Intracerebral Hemorrhage LIU Guangpu DOI: 10.3969/j.issn.1006-6233.2021.06.023 Objective: To study the curative effect of minimally invasive trepanation and drainage via the temporal approach and the frontal approach in the treatment of hypertensive intracerebral hemorrhage (HICH). Methods: This study retrospectively reviewed 106 patients with HICH in left basal ganglia who were diagnosed and treated in the hospital between February 2016 and February 2020. They were divided into the temporal group (48 cases, temporal approach) and the frontal group (58 cases, frontal approach) according to the surgical approach. The two groups were compared with respect to nerve function impairment, perioperative indicators, and activity of daily living, and postoperative complications were counted. Results: The residual hematoma volume of the frontal group was significantly smaller than that of the temporal group at 3d after operation, and the difference was statistically significant (P<0.05), but no statistically significant differences were found in the other indexes (P>0.05). The NIHSS scores and CSS scores of the two groups gradually decreased after operation, and there were statistically significant differences in terms of inter-group effect and time effect (P<0.05). Comparison between different time points showed that the above scores of the frontal group at 3 and 6 months after operation were significantly lower than those of the temporal group, and the differences were statistically significant (P<0.05). The activity of daily living scores of the two groups gradually increased after operation, and there were statistically significant differences in terms of inter-group effect and time effect (P<0.05). Comparison between different time points showed that the above scores of the frontal group at 3 and 6 months after operation were significantly higher than those of the temporal group, and the differences were statistically significant (P<0.05). There were no statistically significant differences between the two groups in the incidences of intracranial infection, lung infection and puncture site bleeding (P>0.05). Conclusion: Minimally invasive trepanation and drainage through both the temporal approach and the frontal approach can safely and effectively remove the hematoma, but the latter has more advantages since it can effectively increase the removed hematoma volume in early stage, and promote recovery of activities of daily living as well as neurological function. 2021 Vol. 27 (6): 990-994 [Abstract] ( 94 ) HTML (1 KB)  PDF (1694 KB)  ( 214 ) 995 Effect of Different Maintenance Time of Dual Antiplatelet Therapy After Intracranial Aneurysm Stent and Coils Embolization on Delayed Cerebral Ischemia MA Ke, LIAO Xiao, LU Huadong, et al DOI: 10.3969/j.issn.1006-6233.2021.06.024 Objective: To study the different effects of different maintenance time of dual antiplatelet therapy on delayed cerebral ischemia after intracranial aneurysm stent combined with coils embolization. Methods: A retrospective analysis was conducted towards 208 hospitalized patients with intracranial aneurysms, who had stent combined with spring coil embolization between January 2017 and January 2019. Patients were divided into 3 groups, namely the short-term group (maintenance time 3 months, and n = 63), medium-term group (maintenance time 6 months, and n = 87) and the long term group (maintenance time more than nine months, n = 58).The cumulative incidence of delayed cerebral ischemia in the three groups was observed. Kaplan-Meier method was used to calculate the cumulative incidence of delayed cerebral ischemia in the three groups, and Log-rank method was used for comparison between the three groups. Cox proportional regression model was used to analyze the independent influencing factors of delayed cerebral ischemia. Results: Among the 208 patients with intracranial aneurysm, 11 cases of delayed cerebral ischemia occurred, including 5 cases in the short-term group and 6 cases in the medium-term group. The cumulative incidence of delayed cerebral ischemia was higher in the short-term and medium-term groups than in the long-term group, and the differences were significant (P<0.05). Univariate Cox analysis showed that the main risk factors of delayed cerebral ischemia were dual antiplatelet duration, Raymond grade, tumor neck width > 4mm, history of diabetes and age (P<0.05).Multivariate Cox analysis showed that the independent risk factors of delayed cerebral ischemia were mainly dual antiplatelet duration and Raymond grade (P<0.05). Conclusion: In patients with intracranial aneurysms, the maintenance time of different dual antiplatelet therapy after stent combined with coil embolization is 9 months or more, which can effectively reduce the incidence of delayed cerebral ischemia. The incidence of delayed cerebral ischemia in patients with intracranial aneurysms increases with the increase of Raymond grade. 2021 Vol. 27 (6): 995-998 [Abstract] ( 142 ) HTML (1 KB)  PDF (1205 KB)  ( 224 ) 999 Clinical Application of Floating Bone Flap Decompression Combined with Intracranial Pressure Monitoring in Craniocerebral Surgery OUYANG Yibin, HE Qinglong, YIN Mantian, et al DOI: 10.3969/j.issn.1006-6233.2021.06.025 Objective: To explore the application value of floating bone flap decompression combined with intracranial pressure monitoring in craniocerebral surgery. Methods: The clinical data of 98 patients with craniocerebral injury admitted to the hospital from March 2019 to August 2020 were retrospectively analyzed. According to different surgical methods, they were divided into an observation group (53 cases) and a control group (45 cases). The observation group was treated with floating bone flap decompression and intracranial pressure monitoring, while the control group was treated with standard decompressive craniectomy and intracranial pressure monitoring. The usage time and dose of mannitol, ICU hospital stay length, intracranial pressure at different time points, Glasgow Coma Scale (GCS), postoperative complications and prognosis were compared between the two groups. Results: There were statistically significant differences in intracranial pressure and GCS scores between the two groups and at different time points (P<0.05). The GCS scores showed statistically significant differences in termof interaction effect (P<0.05). There was no significant difference in intracranial pressure between the two groups at each time point (P>0.05), and the observation group had higher GCS scores than the control group 7 days after operation (P<0.05).After surgery, the dosage of mannitol was higher in the observation group than in the control group (P<0.05), but no significant differences were found in usage time of mannitol and ICU stay between the 2 groups (P>0.05). The incidences of complications such as electrolyte imbalance, renal dysfunction and incisional hernia were lower in the observation group than in the control group (P<0.05), but no significant differences were found between the 2 groups in the incidences of other complications (P>0.05). At 6 months after surgery, the observation group spent less on treatment than the control group (P<0.05), and no significant difference was found in the good prognosis rate between the 2 groups (P<0.05). Conclusion: Floating bone flap decompression combined with intracranial pressure monitoring can greatly reduce intracranial pressure in patients with craniocerebral injury. For prognosis, it is comparable to standard decompressive craniectomy.Also, it can reduce incidences of postoperative complications and avoid secondary cranial repair, thereby reducing the patient’s economical burden. 2021 Vol. 27 (6): 999-1003 [Abstract] ( 107 ) HTML (1 KB)  PDF (1216 KB)  ( 204 ) 1004 Epidemiological Characteristics and Clinical Analysis of 191 Cases of Childhood Measles Complicated with Severe Pneumonia SUN Ling, CUI Xiaowei, SUN Yishuo, et al DOI: 10.3969/j.issn.1006-6233.2021.06.026 Objective: To analyze the epidemiological and clinical characteristics, treatment measures and prognosis of children with measles complicated with severe pneumonia, so as to provide evidence for measles prevention and control and reduce the mortality of severe measles. Methods: From 2011 to 2019, 191 children with measles and severe pneumonia admitted to the inpatient ward of Hebei Children's Hospital were made the research object. The clinical data of the children were retrospectively studied, and the epidemiological characteristics were analyzed by descriptive epidemiology. At the same time, the clinical features, treatment and prognosis of children were also analyzed. Results: The male to female ratio of 191 cases was 1.93:1. The onset time was from January through June, and the age was mainly under 1.5, accounting for 90.06%. The regional distribution was mainly in the surrounding cities and rural areas, accounting for 88.48%; 69 cases ( 36.12%) have a previous medical history, all children have symptoms such as fever, rash, cough, shortness of breath, and three concave signs. The most common complication is laryngitis in 129 cases (67.54%), white blood cells, CRP, myocardial enzymes, liver function, blood sugar, and imaging examinations all had different degrees of abnormality. The sputum culture was mainly Escherichia coli; after comprehensive assessment and targeted treatment, 107 cases (56.02%) were cured and discharged, and 74 cases (38.74%) were improved and discharged. 10 cases died or died after giving up treatment. Conclusion: The overall incidence of measles complicated with severe pneumonia fluctuated significantly from 2011 to 2019, and 2014 was the peak of the incidence. The respiratory, digestive, and cardiovascular systems of the children could be affected. The causes of death were respiratory failure, ARDS, and MODS. The coverage rate and timely vaccination rate of children with measles component vaccine (MCV) should be treated in a timely manner based on clinical manifestations of severely ill children to reduce the mortality rate and improve the prognosis of children. 2021 Vol. 27 (6): 1004-1008 [Abstract] ( 114 ) HTML (1 KB)  PDF (1427 KB)  ( 154 ) 1009 Comparison of Two Different Ultrasound Evaluation Methods in the Differential Diagnosis of BI-RADS 4 Breast Lesions WANG Jin, et al DOI: 10.3969/j.issn.1006-6233.2021.06.027 Objective: To compare the value of the modified ultrasound elastography score and the ultrasound elastic strain ratio in the differential diagnosis of four types of breast benign and malignant lesions in breast imaging reporting and data system for ultrasound (BI-RADS). Methods: A total of 83 cases of breast lesions (96 breast masses) in our hospital were selected, who were graded by modified ultrasound elastography, and the elastic strain ratio of ultrasound was measured. According to the results of operation and pathology, and by plotting the receiver operating characteristic (ROC) curve of the subjects, the diagnostic efficacy of the modified ultrasound elastography and strain ratio in the differential diagnosis of BI-RADS 4 types of breast benign and malignant lesions was evaluated. Results: Among the 96 breast masses, 41 of 4A, 32 of 4B and 23 of 4C were diagnosed by ultrasonography before operation, 56 of them were malignant and 40 of them were benign. The sensitivity, specificity, accuracy and yoden index of the two methods were 69.64% (39 / 56), 73.21% (41 / 56), 72.50% (29 / 40), 82.50% (33 / 40) and 70.83% (68 / 96), 77.08% (74 / 96) respectively. The ROC curve analysis showed that the area under the ROC curve was 0.86, which was higher than that of the modified elastography (0.74). Conclusion: The modified elasto-sonography score and the elastic-strain ratio of ultrasound have important guiding value in the differentiation of four types of breast benign and malignant lesions in BI-RADS, but the elastic-strain ratio of ultrasound may be more reliable and objective, which has a good diagnostic value in the differentiation of four types of breast benign and malignant lesions in BI-RADS. 2021 Vol. 27 (6): 1009-1012 [Abstract] ( 121 ) HTML (1 KB)  PDF (1621 KB)  ( 232 ) 1013 Effects of Right Ventricular Septum Pacing on Cardiac Function WANG Yaling, et al DOI: 10.3969/j.issn.1006-6233.2021.06.028 Objective: To study and compare the effects of right ventricular middle septum pacing and right ventricular high septum pacing on cardiac function. Methods: From January 2018 to March 2020, 100 patients with complete atrioventricular block undergoing permanent pacemaker implantation in our hospital were included in the study, and were divided into 2 groups with 50 patients in each according to the random number table method. Group A was pacing at the high septum of right ventricle, while group B was pacing at the middle septum of right ventricle. The levels of n-terminal brain natriuretic peptide (NT-proBNP), cardiac color Doppler monitoring index, QRS wave time limit, quality of life score and incidence of adverse cardiac events were compared between the two groups. Results: The levels of NT-proBNP in both groups were significantly lower than those before operation at 3 and 6 months after operation (P<0.05), while the levels of NT-proBNP in Group B were lower than those in Group A at 3 and 6 months after operation (P<0.05). The LVEF, LVEDD, LVESD and LAEF at 3 and 6 months after operation were significantly improved in both groups (P<0.05), while the LVEF and LAEF in group B were higher than those in group a (P<0.05), while the LVEDD and LVESD in group B were lower than those in control group (P<0.05). The QRS wave duration of the two groups at 3 months and 6 months after operation was significantly shorter than that before operation (P<0.05), while the QRS wave duration of Group B was shorter than that of Group A at 3 months and 6 months after operation (P<0.05). The quality of life scores of both groups at 3 and 6 months after operation were significantly lower than those before operation (P<0.05), while the quality of life scores of Group B were lower than those of Group A at 3 and 6 months after operation (P<0.05). Within 6 months after operation, the incidence of adverse cardiac events in group A was 8.00%, while that in group B was 4.00%. There was no significant difference between the two groups (P>0.05). Conclusion: Pacing in the middle septum of right ventricle can improve the cardiac function of patients with permanent pacemaker implantation, which is better than pacing in the high septum of right ventricle, and the risk of adverse cardiac events is not increased, which verifies it’s safety and reliability. 2021 Vol. 27 (6): 1013-1017 [Abstract] ( 97 ) HTML (1 KB)  PDF (1240 KB)  ( 136 ) 1018 An Analysis of the Effect of Maternal-Infant Blood l Group Incompatibility on Neonatal Hemolysis ZHAO Jun, ZHANG Lei, et al DOI: 10.3969/j.issn.1006-6233.2021.06.029 Objective: To investigate the high distribution of antibody titers in maternal-fetal ABO blood type incompatibility and its effect on the newborn with ABO blood type incompatible hemolytic disease. Methods: A retrospective analysis of 760 type O Rh-negative parturients (whose husbands are not type O Rh-negative) and their newborns is made to discuss the high distribution of antibody titers and the effect on hemolysis of newborns. Results: Among 760 pregnant women with ABO incompatibility, the titer increases with the increasing of gestational time and gestational age, and the difference is statistically significant. These pregnant women are sub-grouped according to their husbands' ABO blood type, and there is no significant difference in antibody titers between groups. With the increasing of antibody titer, the incidence of hemolytic disease in newborns is on the rise. Conclusion: Dynamic monitoring of maternal antibody titers during pregnancy is significant to reducing neonatal hemolytic disease caused by maternal-fetal ABO blood type incompatibility and can improve the quality of the birth population. 2021 Vol. 27 (6): 1018-1021 [Abstract] ( 96 ) HTML (1 KB)  PDF (1201 KB)  ( 182 ) 1022 The Influence of Lateral Posterior Discectomy, Posterior Discectomy and Open Laminoplasty on SLRT Score and Inflammatory Factor Levels in Patients with Lumbar Disc Herniation YIN Zhenyu, SHI Bo, SONG Jingang, et al DOI: 10.3969/j.issn.1006-6233.2021.06.030 Objective: To compare and analyze the effects of lateral posterior intervertebral foramen, posterior intervertebral discoscopy and open laminectomy on SLRT score and inflammatory factor level. Methods: A total of 90 patients with lumbar disc herniation who were hospitalized and treated in our hospital from June 2018 to May 2019 were prospectively analyzed. They were randomly divided into the endoscopic group and the open group, with 45 cases in each group. The curative effects of two different surgical methods, the levels of inflammatory factors before and after operation and the impact on SLRT scores of the two groups were compared. Results: The postoperative efficiency was 97.78%. The postoperative efficiency of the open group was 84.44%. The effective rate was significantly higher in the foramen group than in the open group, and the difference was statistically significant (P<0.05). The levels of interleukin-6(IL-6), interleukin-8(IL-8), interleukin-17(IL-17) and tumor necrosis factor-α(tnf-α) and tumor necrosis factor-γ(tnf-γ) in both groups after surgery were lower than before, IL-4 levels were higher than before, and the difference was statistically significant (P<0.05). There was significant difference in the IL-4 level and IL-6、IL-8、IL-17、TNF-α、IFN-γ levels in the open group (P<0.05); and the number of degrees of flexion and extension SLRT hip, knee and ankle joints in the foramen group was better than that in the open group, with statistically significant difference (P<0.05). Conclusion: Intervertebral foramen surgery can inhibit the inflammatory reaction and pain degree in patients with lumbar disc herniation, and the effect of intervertebral foramen surgery is better. 2021 Vol. 27 (6): 1022-1026 [Abstract] ( 88 ) HTML (1 KB)  PDF (1291 KB)  ( 330 ) 1027 Effect of Phrenic Nerve Protection in Mediastinal Tumor Resection by Video-Assisted Thoracoscopy and Its Influence on Surgical Indexes and Postoperative Recovery FAN Shaowei, et al DOI: 10.3969/j.issn.1006-6233.2021.06.031 Objective: To investigate the effect of phrenic nerve protection during video-assisted thoracoscopic resection of mediastinal tumor and its influence on surgical indexes and postoperative recovery. Methods: A total of sixty-six patients with mediastinal tumors in our hospital from January 2015 to December 2019 were selected for a prospective study, and were divided into experimental group and control group according to the principle of digital randomness, with 33 patients in each group. The control group was treated with standard thoracotomy. The experimental group underwent mediastinal tumor resection by video-assisted thoracoscopy and phrenic nerve protection measures. The intraoperative and postoperative indicators and phrenic nerve fluctuation were compared. Results: Intraoperatively, the time of thoracotomy (12.07±3.27)min, the amount of thoracotomy blood loss (12.89±4.68) min, and the time of thoracotomy (11.46±2.39)min in the experimental group were all lower than those in the control group, and the differences were statistically significant (P<0.05). The difference in total operation time was not significant, and was not statistically significant ( P>0.05). After the operation, the experimental group had less catheter duration (3.25±0.95) d, drainage volume (365.89±102.49) ml, and length of hospital stay (7.79±2.19) d than the control group, and P<0.05 was statistically significant. Intraoperative and postoperative indicators showed a positive correlation, but the degree of strength was different, P<0.05 was statistically significant. The upsilon /V was (186.25±28.54) in the experimental group and (120.22±25.36) in the control group. There was significant difference in data on the upsilon /V, with t=9.935,P<0.05 being of statistical significance. Conclusion: Video-assisted thoracoscopic resection of mediastinal tumor can reduce the time of thoracotomy, chest closing, hospital stay and catheter insertion, reduce the amount of blood loss, maintain the phrenic nerve, and avoid the phrenic nerve injury. 2021 Vol. 27 (6): 1027-1030 [Abstract] ( 110 ) HTML (1 KB)  PDF (1212 KB)  ( 273 ) 1031 Comparison of Clinical Efficacy of Three Different Surgical Procedures for Lacrimal Canaliculitis ZHANG Qi, LU Shanshan, ZHANG Lei, et al DOI: 10.3969/j.issn.1006-6233.2021.06.032 Objective: To investigate the clinical effects of triangular incision of lacrimal canaliculus combined with calculi removal, punctal dilation combined with lacrimal canaliculus extrusion for calculi removal, and incision of lacrimal canaliculus combined with artificial lacrimal canaliculus placement for lacrimal canaliculitis. Methods: This study was retrospective. A total of 31 patients (31 eyes) with canaliculitis who had surgery in the Affiliated Hospital of Chengde Medical University from June 2017 to March 2020 were selected and divided into group A (10 eyes), group B (12 eyes) and group C (9 eyes) according to surgical methods. Group A was treated with triangular incision of lacrimal canalicular wall for canaliculitis; group B was treated with dilation of tear points and massage of lacrimal canaliculi to rule out lacrimal canalicular calculi; group C was treated with lacrimal canaliculitis by lacrimal canaliculotomy combined with placement of artificial lacrimal canaliculi. Conjunctivitis, punctitis, lacrimal canaliculitis and lacrimal canalicular patency and complications at 3 months after operation were compared among the three groups. Results: The effective rate was 80.0% (8/10) in group A, 66.7% (8/12) in group B, and 100.0% (9/9) in group C. There was a significant difference among the three groups (P<0.05). Conclusion: The lacrimal canaliculus incision combined with artificial lacrimal duct placement is an ideal surgical method for the treatment of lacrimal canaliculitis with good curative effect and less complications. 2021 Vol. 27 (6): 1031-1034 [Abstract] ( 119 ) HTML (1 KB)  PDF (1228 KB)  ( 219 ) 1035 The Diagnostic Efficacy of MRI Quantitative Parameters in the Grading of Glioma and the Correlation Analysis with the Expression of EGFR and Ki-67 in Tumor Tissue CHEN Wen, LI Zesheng, ZHONG Kai DOI: 10.3969/j.issn.1006-6233.2021.06.033 Objective: To explore the diagnostic efficacy of MRI quantitative parameters for the classification of glioma and its correlation with the expression of epidermal growth factor receptor (EGFR) and nuclear proliferation-related antigen (Ki-67) in tumor tissues. Methods: From January 2018 to April 2020, 87 patients with glioma admitted to our hospital were prospectively selected. According to the World Health Organization classification of tumors of the central nervous system, they were divided into low-grade group (grade Ⅱ, n=41) and high-grade group (grade Ⅲ, Ⅳ, n=46). The general data, quantitative parameters of magnetic resonance [volume transfer constant (Ktrans), extravascular extracellular volume fraction (Ve), edema width] were compared between the two groups. The receiver operating characteristic curve (ROC) was used to evaluate the effectiveness of magnetic resonance quantitative parameters in the diagnosis of glioma grading, and the positive rates of EGFR and Ki-67 and the average integral optical density of the two groups were compared. Pearson was used to analyze the relationship between the quantitative parameters of magnetic resonance and the average integrated optical density of tumor tissue EGFR and Ki-67. Results: The Ktrans, Ve and edema width of the high-grade group were higher than those of the low-grade group (P<0.05). The area under the curve (AUC) of MRI quantitative parameters Ktrans, Ve, and edema width in the combined diagnosis of glioma classification was 0.891, which was greater than the single diagnosis of each parameter. The best sensitivity and specificity of combined diagnosis were 80.43% and 87.80%, respectively. The EGFR positive rate, Ki-67 positive rate and the average integrated optical density of EGFR and Ki-67 in the high-grade group were higher than those in the low-grade group (P<0.05). Ktrans, Ve, and edema width were all positively correlated with the average integrated optical density of tumor tissue EGFR and Ki-67 (P<0.05). Conclusion: The quantitative parameters of magnetic resonance have good diagnostic performance in the grading diagnosis of glioma, and are positively correlated with the expression of EGFR and Ki-67 in tumor tissues. Early determination of the changes in the quantitative parameters of magnetic resonance can assist the clinical determination of the graded diagnosis of glioma and the expression of EGFR and Ki-67. 2021 Vol. 27 (6): 1035-1040 [Abstract] ( 161 ) HTML (1 KB)  PDF (1995 KB)  ( 267 ) 1041 Effect of Combined Antihypertensive Regimen on Cardiac Function, Hemodynamics Peripheral Blood Hcy and CRP Levels in Patients with Old Myocardial Infarction and Heart Failure XIN Guoyong, ZHENG Gaomei, ZHANG Huihui DOI: 10.3969/j.issn.1006-6233.2021.06.034 Objective:To explore the effect of combined antihypertensive regimen on cardiac function, hemodynamics, peripheral blood Hcy and CRP levels in the treatment old myocardial infarction combined with heart failure. Methods:A retrospective analysis was conducted with the clinical data of 60 patients with old myocardial infarction and heart failure admitted to our hospital from January 2019 to March 2020 who were divided into groups A, B, and C according to their treatment methods. 22 patients in group A were treated with valerian Sartan combined with benazepril hydrochloride treatment, 20 patients in group B were treated with valsartan alone, and 18 patients in group C were treated with benazepril hydrochloride alone. The blood pressure status and cardiac function indexes of the three groups before and after treatment were compared. Left ventricular ejection fraction (LVEF), left ventricular end-systolic volume (LVESV) and left ventricular end-diastolic volume (LVEDV), hemodynamic indicators Stroke volume (SV), cardiac output (CO) and cardiac index (CI), peripheral blood homocysteine (Hcy), C-reactive protein (CRP) difference and clinical efficacy. Results:①After treatment, the systolic and diastolic blood pressure of group A were significantly lower than those of group B and C, P<0.05; ②After treatment, the LVEF level of group A was higher than that of group B and C, and the levels of LVESV and LVEDV were lower than group B and C; The difference between the LVESV and LVEDV groups was statistically significant, P<0.05; ③After treatment, the three indexes of group A were higher than those in groups B and C, P<0.05; ④After treatment, the levels of Hcy and CRP in group A were significantly lower than in groups B and C, P<0.05; ⑤The total effective rate of patients in group A was 95.45%, which was significantly higher than 80.00% in group B and 77.78% in group C. Conclusion: The combined antihypertensive regimen is effective in treating patients with old myocardial infarction combined with heart failure, which can improve the patient's cardiac contractility, regulate hemodynamic indicators, and reduce Hcy and CRP levels. 2021 Vol. 27 (6): 1041-1044 [Abstract] ( 88 ) HTML (1 KB)  PDF (1220 KB)  ( 170 ) 1045 Efficacy of Levonorgestrel Intrauterine Sustained-Release System in the Treatment of Endometrial Hyperplasia CUI Guanqun DOI: 10.3969/j.issn.1006-6233.2021.06.035 Objective: To explore the efficacy of levonorgestrel intrauterine sustained-release system(LNG-IUS)in the treatment of endometrial hyperplasia. Methods: A total of 260 patients with endometrial hyperplasia admitted in our hospital from April 2019 to April 2020 were selected. The selected patients met the inclusion criteria and were randomly divided into two groups, each with 130 cases. During treatment, medroxyprogesterone acetate was administered to the control group, and LNG-IUS was administered to the observation group. The curative effect was compared through 3 menstrual periods. Results: Before treatment, there was no difference in endometrial thickness and hemoglobin level between the two groups(P>0.05);After treatment, the endometrial thickness and hemoglobin level of the observation group were better than those of the control group(P<0.05).Before treatment, there was no difference in the scores of PBAC, menstrual volume and progesterone receptor between the two groups(P>0.05); After treatment, PBAC, progesterone receptor score and menstrual volume of the observation group were better than those of the control group(P<0.05).The levels of E2(estradiol),P(progesterone),LH(luteinizing hormone) and FSH(serum follicle stimulating hormone)in the observation group were significantly different before and after treatment(P<0.05),with statistical significance; The levels of E2(estradiol),P(progesterone),LH(luteinizing hormone)and FSH(serum follicle stimulating hormone)in the control group were not significantly different before and after treatment(P>0.05).During the treatment period, the LNG-IUS of 3 patients in the observation group fell off due to excessive menstruation,26 cases had abnormal vaginal bleeding,1 case was taken out midway, and 3 cases were closed; In the control group,4 patients had poor symptom control and 6 patients were diagnosed with pregnancy; During the treatment, there were no coagulation, renal and liver dysfunction in both groups. Conclusion: The choice of LNG-IUS for the treatment of endometrial hyperplasia has a definite curative effect and can effectively regulate the level of progesterone, thereby implementing effective treatment for endometrial hyperplasia, which is worthy of promotion. 2021 Vol. 27 (6): 1045-1048 [Abstract] ( 81 ) HTML (1 KB)  PDF (1216 KB)  ( 164 ) 1049 Effect of Ropivacaine and Sufentanil Combined Spinal-Epidural Anesthesia for Cesarean Section on Hemodynamics and Muscle Relaxation DENG Guokui, LI Yunxian, XIE Hong, et al DOI: 10.3969/j.issn.1006-6233.2021.06.036 Objective: To explore the effect of ropivacaine and sufentanil combined spinal-epidural anesthesia for cesarean section on hemodynamics and muscle relaxation. Methods: A prospective selection of 80 parturients who underwent cesarean section in our hospital from January 2019 to June 2020 were randomly divided into two groups according to the random number table method. The control group (40 cases) had ropivacaine combined spinal-epidural anesthesia, and the observation group (40 cases) had ropivacaine combined with sufentanil combined spinal-epidural anesthesia. The changes in heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) levels 15 minutes before anesthesia and 15 minutes after anesthesia between the two groups of women were compared, as well as the degree of muscle relaxation after anesthesia, drug onset time, analgesia time, exercise recovery time, and maternal Bromage exercise score, Apgar score of newborns 15 minutes postpartum, and occurrence of adverse drug reactions. Results: Repeated measurement analysis of variance showed that the time point effect can significantly affect the changes in SBP, DBP and HR levels, and the interaction effect of time point and anesthesia methods can significantly affect the changes in SBP levels (P<0.05); and the decrease in SBP in the observation group after anesthesia was lower than that in the control group (all P<0.05). The excellent and good rate of muscle relaxation in the observation group was 97.50%, which was higher than 85.00% in the control group. The difference was statistically significant (P<0.05). Compared with the control group, the observation group had no statistically significant differences in the time of drug onset, Apgar score of the newborn, Bromage exercise score, analgesia time and exercise recovery time(P>0.05). Conclusion: Ropivacaine and sufentanil combined spinal-epidural anesthesia for cesarean section has little effect on hemodynamics, high rate of muscle relaxation, and does not affect the function of the lower limbs of the mother and the health of the newborn. The drug has high safety. 2021 Vol. 27 (6): 1049-1052 [Abstract] ( 117 ) HTML (1 KB)  PDF (1218 KB)  ( 158 )

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