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2019 Vol. 25, No. 8 Published: 2019-08-31 1233 The Expression Level and Regulation Mechanism of MicroRNA-23a MicroRNA-24-2 and MicroRNA-27a in Patients with Primary Gouty Arthritis LI Ningning, DAI Bingbing, LEI Lei, et al DOI: 10.3969/j.issn.1006-6233.2019.08.001 Objective: To analyze the expression level and regulation mechanism of microRNA-23a (miR-23a), microRNA-24-2 (miR-24-2) and microRNA-27a (miR-27a) in patients with primary gouty arthritis (PGA). Methods: 50 patients with PGA in our hospital were selected as case group and 30 health physical examination personnel as control group. The expression levels of miR-23a, miR-24-2 and miR-27a were detected by real-time fluorescent quantitative PCR. Pearson correlation analysis was used to analyze the relationship between the expressions of miR-23a, miR-24-2 and miR-27a. The data were included in statistical analysis. Results: The plasma fasting blood glucose, uric acid, white blood cell count, neutrophils, triglycerides and apolipoprotein B100 in the case group were significantly higher than those in the control group (all P<0.05), apolipoprotein A1 was significantly lower than those in the control group (P<0.01), but there was no significant difference in total cholesterol between the two groups (P>0.05). Compared with the control group, the expression levels of miR-23a, miR-24-2 and miR-27a in the case group were significantly decreased (P<0.01). Pearson correlation analysis showed that there was a positive correlation between the expression levels of miR-23a, miR-24-2 and miR-27a in peripheral blood mononuclear cells of patients (P<0.01). Urate (100 g/ml) was used to stimulate peripheral blood mononuclear cells in healthy people. The results showed that the expression levels of miR-23a, miR-24-2 and miR-27a in peripheral blood mononuclear cells in the stimulation group were significantly lower than those in the non-stimulation group (P<0.01). Conclusion: Mi-23a, mir-24-2 and mir-27a may play an important role in the inflammatory immune response of PGA as negative inflammatory regulators, and mir-24-2 may regulate the lipoprotein of PGA. 2019 Vol. 25 (8): 1233-1236 [Abstract] ( 168 ) HTML (1 KB)  PDF (1242 KB)  ( 355 ) 1237 Effect of Plasmin on Deep Venous Thrombosis and its Effect on Venous Blood Flow Mechanics of Lower Extremity FAN Huishuang, ZENG Hanqiang, MO Canjun, et al DOI: 10.3969/j.issn.1006-6233.2019.08.002 Objective: To investigate the effect of plasmin on DVT and its effect on deep venous blood flow mechanics of lower limbs. Methods: Prospective selection of 184 DVT patients from June 2017 to February 2018 as subjects in our hospital. Divided into two groups according to the numerical random table method, 92 cases in each group. The control group was treated as a normal treatment, and the observation group was treated for plasmin. To observe the clinical efficacy of two patients. And compare the two groups before and after treatment in patients with hemodynamics and inflammatory reaction. Results: In clinical efficacy, the effective rate of the observation group was 92.39%, which was significantly higher than that of the control group (81.52%) (χ2= 4.792, P<0.05). There were no significant differences in FIB, PV, HSV and LSV between the two groups before treatment (P>0.05). After treatment, the FIB, HSV and LSV in the observation group were significantly lower than those in the control group (t=2.984,3.039,2.197,P<0.05). There were no significant differences in CRP, TNF- and il-6 between the two groups before treatment (P>0.05). After treatment, CRP, TNF-a and IL-6 in the observation group were significantly lower than those in the control group (t=9.999, 6.580, 8.536, P<0.05). Conclusion: Fibrinolytic therapy for DVT patients can improve clinical efficacy, significantly improve hemodynamics, and eliminate inflammatory factors. 2019 Vol. 25 (8): 1237-1239 [Abstract] ( 188 ) HTML (1 KB)  PDF (1214 KB)  ( 266 ) 1240 Effects of Pramipexole combined with Behavioral Therapy on HAMD UPDRS Score Non-motor Symptoms and Quality of Life in Patients with Early-onset Parkinson's Disease and Depression PAN Xiaofeng, et al DOI: 10.3969/j.issn.1006-6233.2019.08.003 Objective: To analyze the effects of pramipexole combined with behavioral therapy on Hamilton depression scale (HAMD), unified Parkinson'sdisease rating scale (UPDRS), non-motor symptoms and quality of life in patients with early-onset Parkinson's disease and depression. Methods: 60 cases of early-onset Parkinson's disease complicated with depression from June 2013 to June 2018 in our hospital were randomly divided into control group treated with pramipexole and combined group treated with pramipexole and behavioral therapy, with 30 cases in each group. The differences of HAMD score and the second and third part of UPDRS scores between the two groups before and 3 months after treatment were compared to assess the degree of depression, non-motor symptoms and quality of life. Results: Compared with before treatment, the HAMD scores of the two groups were significantly decreased at 3 months after treatment (P<0.01); compared with the control group, the HAMD scores of the combined group were significantly decreased at 3 months after treatment (P<0.01). Three months after treatment, the scores of UPDRS in the second part of the two groups were significantly significantly decreased compared with those before treatment, and the score in the combined group was significantly decreased compared with the control group (P<0.01). The scores of UPDRS in the second part of the two groups were significantly decreased compared with those before treatment, and the score in the combined group was significantly decreased compared with the control group (P<0.01). Conclusion: The application of pramipexole combined with behavioral therapy in early-onset Parkinson's disease patients with depression can not only effectively alleviate depression, but also alleviate non-motor symptoms. Therefore, it can promote patients to adjust their mental state, improve their ability of daily living and play an important role in improving their quality of life. 2019 Vol. 25 (8): 1240-1242 [Abstract] ( 126 ) HTML (1 KB)  PDF (1219 KB)  ( 267 ) 1243 The Relationship Between the Level of MiR-19a in Peripheral Blood with BNP and Heart Function of Patients with Ischemic Heart Failure MENG Wenqin, LI Caixia, YU Haixia, et al DOI: 10.3969/j.issn.1006-6233.2019.08.04 Objective: To investigate the relationship between the level of miR-19a in peripheral blood with brain natriuretic peptide (BNP) and heart function of patients with ischemic heart failure. Methods: According to the NYHA classification of heart function, 100 patients with ischemic heart failure were divided into 35 cases of grade II, 42 cases of grade III, 23 cases of grade IV, another 50 healthy persons in the same period were selected as control group. Left ventricular ejection fraction (LVEF), left ventricular anteroposterior diameter (LAD) and left ventricular end-diastolic diameter (LVEDD) were measured by echocardiogram, the serum BNP level was measured by electrochemiluminescence immunoassay, real time fluorescence quantitative PCR (qRT-PCR) was used to detect the expression of miR-19a in peripheral blood, Pearson correlation analyzed the correlations between miR-19a, BNP with LVEF, LAD, LVEDD, receiver operating characteristic curve (ROC) was used to assess the predictive values of miR-19a and BNP for cardiac function classification in patients with ischemic heart failure. Results: Alanine aminotransferase, aspartate aminotransferase, creatinine, urea nitrogen, uric acid and blood glucose in the ischemic heart failure group were significantly higher than those in the control group, while hemoglobin and total cholesterol were significantly lower than those in the control group (P<0.05). With the increase of NYHA grade, LAD and LVEDD gradually increased, LVEF gradually decreased, BNP and miR-19a expressions gradually increased (P<0.05). BNP was positively correlated with LAD and LVEDD (r = 0.382, r = 0.358, P<0.001) and negatively correlated with LVEF (r = - 0.402, P <0.001). MiR-19a was positively correlated with LAD and LVEDD (r = 0.415, r = 0.336, P<0.001), and negatively correlated with LVEF (r = - 0.392, P<0.001). The AUC value of BNP for predicting grade III of heart function was 0.753, and the AUC value of BNP for predicting grade IV of heart function was 0.704. The AUC value of miR-19a for predicting grade III of heart function was 0.838, and the AUC value of miR-19a for predicting grade IV of heart function was 0.795. Conclusion: The levels of microRNA-19a and BNP in peripheral blood of patients with ischemic heart failure were increased, which were positively correlated with cardiac function parameters, and could be used as predictors of cardiac function classification. 2019 Vol. 25 (8): 1243-1248 [Abstract] ( 120 ) HTML (1 KB)  PDF (1656 KB)  ( 210 ) 1249 Effect of Intracoronary Micorandil Injection on slow/no-reflow Flow and Risk Factors in Patients with NSTEMI Undergoing Percutaneous Coronary Intervention SONG Changlai, FU Xin, SUN Jiangtao DOI: 10.3969/j.issn.1006-6233.2019.08.005 Objective: To investigate the effect and risk factors of intracoronary injection of nicorandil on slow flow / no reflow during percutaneous coronary intervention in patients with NSTEMI. Methods: 110 patients with acute non-ST-segment elevation myocardial infarction (NSTEMI) admitted to our hospital from June 2016 to June 2018 were divided into control group and experimental group according to TIMI shunt of target lesions after percutaneous coronary intervention. Among them, patients with TIMI no more than grade 2, i.e. slow flow/no reflow, were divided into experimental group (25 cases), while patients with TIMI grade 3, i.e. patients with normal reflow, were divided into control group (85 cases). The general data of two groups of patients were recorded, and the related indicators of coronary interventional surgery in two groups were observed, the occurrence of major adverse cardiac events in two groups during hospitalization were compared, and the blood flow indicators before and after the application of nicorandil in the experimental group were analyzed. Logistic regression analysis was used to analyze the related factors affecting slow/no-reflow flow during interventional procedures. Results: The proportion of patients with hyperlipidemia, diabetes history, smoking history, etc. in the experimental group was significantly higher than that of the control group (P<0.05). There was no significant difference in the intraoperative center rate between the two groups (t=0.241, P>0.05). The thrombus signs and incidence of intraoperative hypotension in the experimental group were significantly higher than those in the control group (χ2=8.273, χ2=6.394, χ2=6.028, t=22.349, χ2=5.273, all P<0.05). During the hospitalization period, 1 patient in the experimental group died due to cardiogenic shock, and there was no recurrence of myocardial infarction in both groups and no significant difference in the incidence of major cardiac adverse events in the two groups (all P>0.05). The ratio of TMPG3 level and TIMI blood flow level 3 in the experimental group was significantly higher than that before the treatment in this group (χ2=47.232, χ2=53.234, P<0.05). After treatment with nicorandil, CTFC of the experimental group was significantly lower than that of this group (t=8.273, P<0.05). Thrombosis, multiple stents, intraoperative hypotension, diabetes history, and smoking history were all risk factors for slow blood flow/no complex flow (all P<0.05). Conclusion: Thrombosis, signs of hypotension, multiple stents, history of diabetes mellitus and smoking during PCI are all related risk factors affecting the occurrence of slow/no-reflow coronary flow in patients with NSTEMI. Intracoronary nicorandil injection can effectively improve slow/no-reflow coronary flow in patients with NSTEMI. 2019 Vol. 25 (8): 1249-1252 [Abstract] ( 113 ) HTML (1 KB)  PDF (1234 KB)  ( 320 ) 1253 Effect of Hemoperfusion combined with Hemodialysis on Renal Function and T-lymphocyte Levels in Patients with Uremia SONG Pei DOI: 10.3969/j.issn.1006-6233.2019.08.006 Objective: To investigate the effect of hemoperfusion combined with hemodialysis on renal function and T-lymphocyte levels in patients with uremia. Methods: 100 patients with uremia were randomly divided into observation group and control group, with 50 cases in each group. Control group were received hemodialysis and observation group were received hemoperfusion combined with hemodialysis. After 6 months of treatment, the changes of clinical symptoms and quality of life were observed. The indexes of renal function and T-lymphocyte levels were detected before and after treatment. Results: The clinical symptoms in two group were significantly improved after treatment, while the occurrence rates of skin pruritus, dizziness, headache, inappetence and hypertension in observation group were significantly lower than those in control group (P<0.05). The scores of SF-36 in two groups after treatment were increased and the scores of RE, MH, SF, BP, VT and GH in observation group were higher than those in control group (P<0.05). The levels of Scr, BUN and β2-MG level in observation group were lower than those in control group, while the CD3+, CD4+ and CD4+/CD8+ level was significantly higher than control group (P<0.05). Conclusion: Hemoperfusion combined with hemodialysis is helpful to improve the life quality of patients with uremia. It can improve the renal function and immunologic function. 2019 Vol. 25 (8): 1253-1256 [Abstract] ( 111 ) HTML (1 KB)  PDF (1236 KB)  ( 337 ) 1257 Curative Efficacy of Aspirin Combined with Diosmin in Treatment of Postoperative Varicose Great Saphenous Vein and Influence on Coagulation Function Serum Serpine1 and KLF2 Levels SHI Wanqing, CHEN Keli, SONG Qinghong DOI: 10.3969/j.issn.1006-6233.2019.08.007 Objective: To study the curative efficacy of aspirin combined with diosmin in treatment of postoperative varicose great saphenous vein and effects on coagulation function, serum plasminogen activator inhibitor(serpine1) and Kruppel like transcription factor 2(KLF2) levels. Methods: 95 patients of postoperative varicose great saphenous vein who received therapy from January 2016 to May 2018 in our hospital were as theis research, and they were divided into the 50 cases of the observation group and 45 cases of the control group by the simple random number table, they were given routine preventive treatment after operation on the basis of, the control group was given aspirin treatment, and the observation group was combined with Diosmin treatment on the basis of the control group, thye were given drugs continuously for 2 weeks. The coagulation function, serpine1, KLF2, leg symptoms, incidence of deep vein thrombosis in lower extremities and adverse reactions were compared between the two groups. Results: The activation time of partial thromboplastin (APTT), prothrombin time (PT) and thrombin time (TT) in the observation group were significantly longer than those in the control group at after treatment 3 and 7 days(P<0.05); the serum serpine1 in the observation group was significantly lower than those in the control group, and KLF2 was significantly higher than those in the control group at after treatment 3 and 7 days(P<0.05); after treatment, the weight and visual analogue scale (VAS) scores in the observation group were significantly lower than those in the control group(P<0.05); the incidence of deep vein thrombosis in lower extremities in the observation group was significantly lower than those in the control group(P<0.05); there was no significant difference in adverse reactions between the two groups during treatment(P>0.05). Conclusion: Aspirin combined with diosmin is well for postoperative varicose great saphenous vein, which can effectively regulate the serum serpine1 and KLF2 levels, improve the coagulation function, prevent the formation of deep vein thrombosis in lower extremities, and has high safety, it's worthy of clinical application and promotion. 2019 Vol. 25 (8): 1257-1260 [Abstract] ( 375 ) HTML (1 KB)  PDF (1240 KB)  ( 428 ) 1261 Changes of Serum HSP70 and Hydrogen Sulfide Levels in Patients with Acute Respiratory Distress Syndrome and Their Relationships with Prognosis SHI Yubin, GAO Xinhai, SHEN Yangfan, et al DOI: 10.3969/j.issn.1006-6233.2019.08.008 Objective: To detect the levels of serum heat shock protein 70 (HSP70) and hydrogen sulfide (H2S) in patients with acute respiratory distress syndrome (ARDS), and to analyze their relationships with the prognosis of the disease. Methods: 90 patients with ARDS admitted to our hospital from May 2015 to May 2018 were divided into 49 cases in death group and 41 cases in survival group. Enzyme linked immunosorbent assay (ELISA) was used to detect serum HSP70 and H2S levels, all subjects were scored by APACHE- II, the inhaled oxygen concentration (FiO2) and arterial partial pressure of oxygen (PaO2) were measured by blood gas analyzer, and the oxygenation index was calculated. Results: The APACHE-II score in the death group was significantly higher than that in the survival group (P<0.05), the oxygenation index in the death group was significantly lower than that in the survival group (P<0.05), the number of extrapulmonary ARDS in the death group was significantly higher than that in the survival group (P<0.05); serum H2S and HSP70 levels of ARDS patients in the survival group were significantly higher than those in the death group (P<0.05); the serum levels of H2S and HSP70 in severe ARDS patients were significantly lower than those in moderate ARDS patients (P<0.05), and the serum levels of H2S and HSP70 in moderate ARDS patients were significantly lower than those in mild ARDS patients (P<0.05); ROC curve analysis showed that serum H2S and HSP70 levels alone detections had certain values in predicting the prognosis of ARDS patients; the combined detection of AUC was 0.885, sensitivity was 77.60%, specificity was 92.90%; multivariate analysis showed that APACHE-II score, oxygenation index, serum H2S level, and serum HSP70 level were independent risk factors affecting the prognosis of patients. Conclusion: The serum H2S and HSP70 levels in ARDS survival group are increased significantly, lower oxygenation index (PaO2/FiO2), lower serum H2S level, and lower serum HSP70 level are risk factors for all-cause mortality in ARDS patients within 30 days, which may be a biomarker of prognosis of ARDS. 2019 Vol. 25 (8): 1261-1264 [Abstract] ( 127 ) HTML (1 KB)  PDF (1379 KB)  ( 307 ) 1265 Effects of Ambroxol Hydrochloride combined with Montelukast Sodium on Serum Levels of MMP-9 TIMP-1 and IL-6 in Children with Asthma LU Fang, ZHU Yan DOI: 10.3969/j.issn.1006-6233.2019.08.009 Objective:To explore the different administration routes of ambroxol hydrochloride combined with montelukast sodium om serum levels of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1(TIMP-1) and interleukin-6 (IL-6) in children patients with asthma. Methods:84 cases of children patients with asthma admitted to our hospital were evenly divided into atomization group and intravenous drip group according to the random number table method. On the basis of conventional treatment and montelukast sodium chewable tablets, atomization group was given atomization inhalation of ambroxol hydrochloride, and intravenous drip group was given intravenous drip of ambroxol hydrochloride. Clinical efficacy, disappearance times of symptoms and signs, pulmonary ventilation function and serum markers were compared between the two groups. Results:After treatment, the total effective rate in atomization group was significantly higher than that in intravenous drip group (95.24% vs 76.19%) (P<0.05). The disappearance times of fever, asthma, cough and lung rale in atomization group were earlier than that in intravenous drip group (P<0.05). There were no significant differences in the levels of pulmonary artery resistance index (RI), pulmonary shunt rate (Qs/Qt), partial pressure difference of alveolar-arterial oxygen (PA-aDO2), maximal inspiratory pressure (PIMAX), serum MMP-9, TIMP-1, IL-6 and osteopontin (OPN) between the two groups before treatment (P>0.05), but the differences of above indexes before and after treatment in atomization group were greater than those in intravenous drip group (P<0.05). Conclusions: Ambroxol hydrochloride combined with montelukast sodium can effectively control the condition of children with asthma, and the efficacy of aerosol inhalation is better than intravenous drip, which may be related to the reduction of serum levels of MMP-9, TIMP-1, IL-6 and OPN. 2019 Vol. 25 (8): 1265-1268 [Abstract] ( 143 ) HTML (1 KB)  PDF (1236 KB)  ( 361 ) 1269 Effect of Adrenocortical Hormone combined with Cefuroxime on Children with Severe Pneumonia and its Influence on Immune Function LIU Yunjun, LIU Shihu DOI: 10.3969/j.issn.1006-6233.2019.08.010 Objective: To explore the therapeutic effect of adrenal cortex hormones combined with cefuroxime in children with severe pneumonia and its effects on immune function. Methods: 180 cases of children with severe pneumonia admitted to our hospital from January 2015 to December 2017 were divided into the observation group (n=90) and the control group (n=90) according to the simple random grouping method. The two groups were given the removing phlegm, relieving asthma and cough and other conventional symptomatic treatment, and the control group was given the daily intravenous drop of cefuroxime, and the observation group was additionally given the intravenous drop of methylprednisolone. The clinical efficacy, the inflammatory factors levels [interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor α (TNF-α), C-reactive protein (CRP)] and immune function indexes were compared between the two groups. And the improvement time of antipyretic and pulmonary rales disappearance symptoms, and the ICU stay, total hospital stay and adverse reactions during treatment were recorded in the two groups. Results: The total effective rate of efficacy in the observation group was significantly higher than that in the control group [88.89% (80/90) vs 77.78% (70/90)] (P<0.05). After treatment, the levels of IL-10, CD3+, CD4+ and CD4+/ CD8+ in the observation group were significantly higher than those in the control group, and the levels of IL-6, TNF-α, CRP and CD8+ were significantly lower than those in the control group, and the antipyretic time and the pulmonary rales disappearance time were significantly earlier than those in the control group, and the ICU stay and total hospital stay were significantly shorter than those in the control group (P<0.05). The incidence rate of adverse reactions in the observation group was slightly lower than that in the control group [5.56% (5/90) vs 12.22% (11/90) ](P>0.05). Conclusion: Adrenal cortex hormones combined with cefuroxime can have an exact clinical efficacy in children with severe pneumonia, and it can significantly improve the inflammatory reactions and clinical symptoms, enhance the immune function and shorten the hospital stay, and it has high safety. 2019 Vol. 25 (8): 1269-1272 [Abstract] ( 139 ) HTML (1 KB)  PDF (1213 KB)  ( 273 ) 1273 Effects of Tetramethylpyrazine Hydrochloride on Visual Acuity and Vascular Endothelial Function in NPDR Patients WANG Qian, et al DOI: 10.3969/j.issn.1006-6233.2019.08.011 Objective: To explore the effects of tetramethylpyrazine hydrochloride on visual acuity and vascular endothelial function in patients with non-prolifertive diabetic retinopathy (NPDR). Methods: A total of 142 patients with NPDR admitted to our hospital from October 2016 to October 2018 were selected and divided into two groups according to the simple random grouping. The two groups were given basic treatment, and 71 patients in control group were treated with calcium dobesilate tablets, and 71 patients in observation group were given tetramethylpyrazine hydrochloride tablets on the basis of control group. The treatment efficacy, and visual acuity, intraocular pressure, macular edema and macular thickness, and plasma vascular endothelial growth factor (VEGF), endothelin-1 (ET-1) and endothelium-dependent flow-mediated dilatation (FMD) before and after treatment were compared between the two groups. Results: The total effective rate of treatment in observation group was significantly higher than that in control group (92.96% vs 81.69%) (P<0.05). After treatment, the visual acuity in observation group was significantly better than that in control group (P<0.05), and the macular edema score was significantly lower than that in control group, and the macular thickness was significantly lower than that in control group (P<0.05). The levels of VEGF and ET-1 in observation group were significantly lower than those in control group while the FMD value was significantly higher than that in control group (P<0.05). However, there was no significant change in intraocular pressure between the two groups before and after treatment (P>0.05). Conclusion: Teramethylpyrazine hydrochloride can effectively improve the vision of NPDR patients, reduce macular edema and improve vascular endothelial function. 2019 Vol. 25 (8): 1273-1275 [Abstract] ( 108 ) HTML (1 KB)  PDF (1215 KB)  ( 294 ) 1276 Effects of Gefitinib Targeted Therapy on Epidermal Growth Factor and Immune Function in Patients with Non-small Cell Lung Cancer XU Haifeng, DONG Yuchao, QIN Hao, et al DOI: 10.3969/j.issn.1006-6233.2019.08.012 Objective: To study the effects of gefitinib targeted therapy on epidermal growth factor and immune function in patients with late stage EGFR gene mutation non-small cell lung cancer (NSCLC). Methods: 120 patients with late stage EGFR gene mutation NSCLC who were admitted to the hospital from January 2016 to August 2017 were selected and divided into control group and observation group according to simple random grouping method. Control group was given conventional chemotherapy regimen, and observation group was given gefitinib on the basis of control group, and they were treated for 4 cycles with a cycle of 28d. The efficacy, incidence rate of toxic and side effects of III and IV chemotherapy were counted in the two groups. The levels of T lymphocytes, immunoglobulins, serum and pleural effusion EGFR were detected. Results: The disease control rate and effective rate of treatment in observation group were higher than those in control group (P<0.05). The CD3+, CD4+ and CD4+/CD8+ levels in observation group after treatment were higher than those in control group while the CD8+ level was lower than that in control group (P<0.05). The immunoglobulins indexes in observation group after treatment were higher than those in control group (P<0.05). The levels of epidermal growth factor receptor (EGFR) in serum and pleural effusion after treatment in observation group were lower than those in control group (P<0.05). Conclusions: Gefitinib targeted therapy can significantly reduce EGFR level and improve immune function in the treatment of late stage EGFR gene mutation NSCLC. 2019 Vol. 25 (8): 1276-1279 [Abstract] ( 124 ) HTML (1 KB)  PDF (1225 KB)  ( 195 ) 1280 Effects of Adenosine Monophosphate combined with Pulmicort Respules on Serum LTE4, MCP-1 and INF-gamma in Children with Bronchiolitis CHAO Yujin DOI: 10.3969/j.issn.1006-6233.2019.08.013 Objective: To study Curative efficacy of Vidarabine monophosphate combined with primeresch in treatment of Children with bronchiolitis and its effectson serum Leukotriene E4 (LTE4), monocyte chemokinin-1 (McP-1), interferon-gamma (inf-gamma). Methods: 90 children with bronchiolitis treated in our hospital from February 2015 to February 2017 was conducted, they were randomly divided into observation group (n=48) and control group (n=42). The observation group was treated with adenosine monophosphate combined with pulmicort respules. The control group was treated with pulmicort respules. The clinical efficacy, serum LTE4, McP-1, inf-gamma, TNF- alpha, interleukin-6 (il-6), interleukin-8 (il-8), time of disappearance of clinical symptoms and adverse reactions in the two groups were compared. Results: The effective rate of the observation group was 95.83%, significantly higher than that of the control group (80.95%, P<0.05). After treatment, serum LTE4, McP-1 and inf-gamma levels were significantly improved in the two groups (P<0.05). Serum LTE4 and McP-1 levels in the observation group were lower than those in the control group, and inf-gamma levels were significantly higher than those in the control group (P<0.05). After treatment, serum tnf-alpha, il-6 and il-8 levels were significantly improved in both groups (P<0.05). Serum tnf-alpha, il-6 and il-8 levels in the observation group were lower than those in the control group (P<0.05). The time of antipyretic, time of disappearance of moist rale, time of disappearance of wheezing, time of disappearance of cough and time of hospitalization in the observation group was significantly lower than that in the control group (P<0.05). The total incidence of rash, nausea, diarrhea and angioedema in the two groups was 8.33% and 16.67%, respectively, with no statistically significant difference (P>0.05). Conclusion: The efficacy of adenosine monophosphate combined with pramikacin in the treatment of bronchiolitis in children is relatively high, which can effectively improve the serum LTE4, McP-1 and inf-gamma levels in patients with less adverse reactions, and the children are basically tolerable and worthy of popularization and application. 2019 Vol. 25 (8): 1280-1283 [Abstract] ( 140 ) HTML (1 KB)  PDF (1235 KB)  ( 318 ) 1284 Effects of Flurbiprofen Axetil Combined with Dezocine on Hemodynamics and Postoperative Analgesia Effects in Patients Undergoing Radical Resection of Colon Cancer XIE Peng, LI Haiying , XU Jing, et al DOI: 10.3969/j.issn.1006-6233.2019.08.014 Objective:To analyze the effects of flurbiprofen axetil combined with dezocine on hemodynamics and postoperative analgesia effects in patients undergoing radical resection of colon cancer. Methods: A total of 94 patients undergoing radical resection of colon cancer admitted to our hospital from January 2016 to December 2018 were selected and divided into observation group and control group according to the random number table method, with 47 cases in each group. The two groups were given patient-controlled intravenous analgesia (PCIA), and control group was treated with dezocine formula (30 mg), and observation group was given formula of flurbiprofen axetil (150 mg) and dezocine (30 mg). Heart rate (HR) and mean arterial blood pressure (MAP) were routinely monitored before surgery, at the end, the 12 h , the 24 h and the 48 h after surgery. At 2 h, 4 h, 8 h, 12 h and 24 h after surgery, the pain level was evaluated by visual analogue scale (VAS), and the postoperative sedation effects were evaluated by sedation degree score (Ramsay). The occurrence of adverse reactions was recorded in the two groups. Results:The changes of HR and MAP values in observation group were significantly lower than those in control group before surgery and at different time points after surgery (P<0.05). At different time points after surgery, the VAS score and Ramsay score in observation group were significantly lower than those in control group (P<0.05). The incidence rate of adverse reactions in observation group was significantly lower than that in control group (6.38% vs 21.28%) (χ2=4.374, P=0.036). Conclusions:Flurbiprofen axetil combined with dezocine can effectively maintain hemodynamic stability and relieve postoperative pain of patients after radical resection of colon cancer. 2019 Vol. 25 (8): 1284-1287 [Abstract] ( 88 ) HTML (1 KB)  PDF (1238 KB)  ( 319 ) 1288 Effect of Uterine Artery Embolization on Estradiol, Luteinizing Hormone and Follicle Stimulating Hormone Levels in Patients with Postpartum Hemorrhage XU Yan, YOU Huijuan DOI: 10.3969/j.issn.1006-6233.2019.08.015 Objective:To investigate the effects of uterine artery embolization on the levels of estradiol luteinizing hormone and follicle stimulating hormone in postpartum hemorrhage patients. Methods: 60 patients with postpartum hemorrhage admitted to our hospital from January 2016 to December 2018 were divided into two groups according to whether the patients received uterine artery embolization. The patients in group A were treated with uterine artery embolization, while those in group B were treated with non-uterine artery embolization. The amount of postpartum hemorrhage and hospital stay in 24 hours were recorded. The ICU occupancy rate, hysterectomy rate, puerperal infection rate and postpartum hemorrhage rate were compared between the two groups. The changes of follicle-stimulating hormone, luteinizing hormone and estradiol levels before and after treatment were analyzed. Results: There was no significant difference in hospital stay between the two groups (t=0.625, P>0.05). Postpartum hemorrhage within 24 hours in group a was (1039.28±53.44) ml, significantly lower than that in group b (2734.39±43.29) ml (t=6.283, P<0.05). There was no significant difference in puerperal infection rate between the two groups (P>0.05). The ICU occupancy rate, uterine resection rate and postpartum hemorrhage rate in group a were 43.75%, 0 and 46.88%, respectively, lower than those in group b 78.57%, 7.14% and 85.71% (t=10.282, t=5.394, t=11.283, all P<0.05). There were no significant differences in the levels of follicular maturation hormone, luteinizing hormone and estradiol between the two groups before treatment (all P>0.05). After treatment, the levels of follicle-stimulating hormone, luteinizing hormone and estradiol in group a were significantly higher than those in group b (t=3.293, t=4.383, t=5.384, all P<0.05). Conclusion: Uterine artery embolization for postpartum hemorrhage patients can effectively improve the therapeutic effect, and will not have a greater impact on ovarian function, follicle-stimulating hormone, luteinizing hormone and estradiol levels. It is worthy of clinical application. 2019 Vol. 25 (8): 1288-1290 [Abstract] ( 90 ) HTML (1 KB)  PDF (1220 KB)  ( 353 ) 1291 Clinical Efficacy of Invasive-noninvAsive sequential Mechanical Ventilation in the treatment of Traumatic ARDS and its Effect on Serum NT-proBNP and Inflammatory Factors WANG Xinfeng, YANG Aizhen, DING Zhaoyong, et al DOI: 10.3969/j.issn.1006-6233.2019.08.016 Objective: To observe the clinical curative effect of invasive-noninvasive sequential mechanical ventilation on traumatic acute respiratory distress syndrome (ARDS) and the influences levels of serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) and inflammatory factors in serum. Methods: 96 patients with traumatic ARDS who were admitted to the hospital and needed mechanical ventilation from October 2016 to October 2018 were randomly divided into 2 groups, 48 cases in each group. Group A was given invasive-noninvasive sequential mechanical ventilation, while group B was given simple invasive mechanical ventilation. The blood gas analysis indexes before and at 24h after treatment, levels of serum NT-proBNP and inflammatory factors [interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α)] before and at 3d after treatment were compared between the 2 groups. The indexes of mechanical ventilation and conditions after weaning in the 2 groups were observed. Results: The blood pH, PaCO2 and PaO2 in the 2 groups were significantly improved at 24h after treatment (P<0.05), There was no significant difference in the above indexes between the two groups before and after treatment (P>0.05). The difference values of serum NT-proBNP, IL-6 and TNF-α levels before and after treatment in group A were significantly higher than those in group B (P<0.05). The total ventilation time, invasive ventilation time and length of stay in ICU of group A were significantly shorter than those of group B, and the incidence of VAP was significantly lower than that in group B (P<0.05). Conclusion: The invasive-noninvasive sequential mechanical ventilation can effectively improve blood gas indexes, relieve heart injury and inflammation, decreased incidence of VAP and shorten the rehabilitation process of patients with traumatic ARDS. 2019 Vol. 25 (8): 1291-1294 [Abstract] ( 102 ) HTML (1 KB)  PDF (1220 KB)  ( 295 ) 1295 Effects of Three Different Blood Purification Methods on Serum β2-MG Calcium and Phosphorus Concentrations and Parathyroid Hormone Levels in Patients with Uremia WANG Yujing DOI: 10.3969/j.issn.1006-6233.2019.08.017 Objective:To analyze the effects of three different blood purification methods on serum β2 microglobulin (β2-MG), calcium and phosphorus concentrations and parathyroid hormone (PTH) levels in patients with uremia. Methods:A total of 100 patients with uremia who were admitted to the hospital during the period from May 2015 to May 2018 were selected as subjects. They were randomly divided into HFHD group (treated with high-flux hemodialysis, n=34), HDF group (treated with hemodiafiltration, n=32) and HD+HP group (treated with hemodialysis and hemoperfusion, n=34). All groups were given 3 months of treatment. The total treatment response rate, serum creatinine (Scr), blood urea nitrogen (BUN), KT / V value, serum β2-MG, blood calcium, serum phosphorus, calcium-phosphorus product and PTH levels before and after treatment were compared among the three groups. Results:The total treatment response rate of HFHD group (91.18%)or HD+HP group (94.12%) were significantly higher than that of HDF group (68.75%)(P<0.05). The BUN and Scr in all groups were after treatment, but there was no significant difference in BUN, Scr or KT/V value among the three groups (P>0.05). Theserum β2-MG, serum phosphorus, calcium-phosphorus product and PTH levels in HFHD group and HD+HP group were significantly lower than those in HDF group, with statistically significant differences between HFHD group and HD+HP group (P<0.05). Conclusion: All of the three blood purification methods can well treat uremia. The therapeutic effects and the improvement of serum β2-MG, blood phosphorus, calcium-phosphorus product and PTH by HFHD or HD+HP are better than HDF, especially HD+HP. 2019 Vol. 25 (8): 1295-1298 [Abstract] ( 132 ) HTML (1 KB)  PDF (1236 KB)  ( 414 ) 1299 Effect of Ulinastatin on Lipopolysaccharide-induced Acute Lung Injury in Rats based on TLR4/MyD88/NF-kappa B pathway WANG Xi, MU Qiantu, et al DOI: 10.3969/j.issn.1006-6233.2019.08.018 Objective: To observe the ulinastatin on acute lung injury induced by lipopolysaccharide in mice protection and of TLR4/MyD88/NF-κB signaling pathway. Methods: 48 SPF Wistar male rats aged 12-15 weeks were randomly divided into four groups. The acute lung injury (ALI) model was established by intravenous injection of 0.5mL lipopolysaccharide (LPS) (5mg/kg) into the tail of the model group. The control group was given saline of equal volume. The dexamethasone (DXM) intervention group and ulinastatin (UTI) intervention group were given intraperitoneal injection of 1 mL dexamethasone (2 mg/kg) and 1 mL dexamethasone (1 mL) 24 hours and 10 minutes before LPS injection, respectively. UTI solution (5 mg/kg) was pretreated, while the control group and the model group were given saline of equal volume instead. The weight loss ratio and wet-dry weight ratio (W/D) of lung tissue were calculated for 10 hours. Pulmonary vascular endothelial permeability was measured by Evanslan method. Lung pathological changes were observed by hematoxylin-eosin staining (HE) and scored. The levels of TNF-alpha, IL-6 and IL-1 beta in bronchial lavage fluid (BALF) were detected by ELISA. The number of total cells and neutrophils was observed and counted under microscope. The expression of TLR4, MyD88 and NF-kappa B proteins in TLR4/MyD88/NF-kappa B signaling pathway was detected by Western blot. Results: Compared with control group, model group and DXM intervention group rats weight and UTI intervention group were obviously decreased (P<0.05), compared with model group, DXM intervention group and UTI intervention group obviously increased (P<0.05). Compared with control group, model group rats after by LPS stimulation, W/D ratio increased significantly (P<0.05); Compared with model group, DXM intervention group and UTI intervention group W/D ratio significantly decreased (P<0.05). Compared with control group, model group appeared the number of neutrophil and total cells in BALF significantly increased (P<0.05); Compared with model group, DXM group and ulinastatin group the number of neutrophil and total cells in BALF of obvious declined(P<0.05).Compared with control group, model group rats with Evans blue concentration appear obviously increased (P<0.05), compared with model group and DXM group and UTI group rats Evans blue concentration significantly decline, statistically significant difference (P<0.05). The control structure of lung tissue integrity, no congestion, the alveolar cavity was clear, interval found no edema and inflammatory cell infiltration. Compared with control group, the mo new alveolar cavity decreased significantly, interval appeared thickened, alveolar walls appeared hyperemia and edema, and found a lot of inflammatory cells infiltration, HE score significantly higher than the control group (P<0.05). And DXM group, ulinastatin group compared with model group, was close to normal lung tissue structure, inflammatory cells infiltration, DXM group and ulinastatin group HE scores significantly lower than the model group, the difference was statistically significant (P<0.05). Compared with control group, model group of IL-6 and IL-1,TNF-αlevel appear obviously increased (P<0.05); Compared with model group and DXM group and ulinastatin group rat BALF of IL-6 and IL-1, TNF-αlevel appear obvious dropped, statistically significant difference (P<0.05). Compared with control group, model group of TLR4, MyD88, NF-κB protein expression increased significantly (P<0.05); Compared with model group, TLR4, MyD88, NF-κB protein expression in DXM group and ulinastatin group decreased obviously, statistically significant difference (P<0.05). Conclusion: Ulinastatin can inhibit the activation of TLR4/MyD88/NF-kappa B signaling pathway induced by LPS, thereby alleviating inflammatory response and exerting protective effect on LPS-induced lung injury. 2019 Vol. 25 (8): 1299-1303 [Abstract] ( 98 ) HTML (1 KB)  PDF (1695 KB)  ( 347 ) 1304 Effects of 3D Laparoscopic Radical Prostatectomy on Perioperative Indexes, Continence Recovery and Postoperative Complications in Patients with Prostate Cancer WANG Shiqin, et al DOI: 10.3969/j.issn.1006-6233.2019.08.019 Objective:To observe the effects of 3D laparoscopic radical prostatectomy (3D-LRP) on perioperative indexes, continence recovery time and postoperative complications in patients with prostate cancer (Pca). Methods: The data of 110 patients with Pca treated by LRP in the department of urinary surgery of the hospital from May 2015 to December 2017 were retrospectively analyzed. 58 patients treated with 3D-LRP were included in the 3D group, and 52 patients treated with 2D-LRP were included in the 2D group. Perioperative indicators, postoperative continence recovery, incidence of postoperative urinary incontinence and sexual dysfunction in both groups were observed. Results: The surgery of all patients was successful. The surgical time of 3D group was significantly shorter than that of 2D group, and the intraoperative blood loss and blood transfusion rate were significantly less/lower than those of 2D group (P<0.05). There was no significant difference in postoperative leakage urine rate, positive rate of resection margin or retention rate of vascular nerve tract between the two groups (P>0.05). The continence recovery in 3D group was better than that in 2D group at 1 month, 2 months, 3 months and 4 months after removal of urinary catheter (P<0.05). Patients with sexual dysfunction in 3D group were significantly fewer than 2D group, and the incidence of urinary incontinence at 3 months after surgery was significantly lower than that in 2D group. Conclusion: 3D-LRP is effective in the treatment of Pca, and it can effectively improve continence. 2019 Vol. 25 (8): 1304-1307 [Abstract] ( 116 ) HTML (1 KB)  PDF (1240 KB)  ( 312 ) 1308 Efficacy of Endoscopic Adenoidectomy and Tonsillectomy in the Treatment of Obstructive Sleep Apnea Hypopnea Syndrome in Children LI Longqiao, WANG Shengguo, SHI Xianping, WU Feifeng, et al DOI: 10.3969/j.issn.1006-6233.2019.08.020 Objective: To explore the clinical effects of endoscopic adenoidectomy and tonsillectomy in the treatment of obstructive sleep apnea hypopnea syndrome (OSAHS) in children. Methods: 86 children patients with OSAHS in our hospital were selected and divided into observation group and control group by simple random grouping, with 43 cases in each group. Control group was treated with continuous positive airway pressure (non-surgical treatment), and observation group was given endoscopic adenoidectomy and tonsillectomy. After 3 months of treatment, polysomnography (PSG) was performed, and the clinical efficacy of children patients was observed, and the quality of life of children patients was assessed by OSA-18 scale. Results: The effective rate of treatment in observation group was significantly higher than that in control group (93.02% vs 76.74%) (P<0.05). The changes of PSG results before and after treatment in the two groups showed the decrease of AHI, increase of lowest SaO2 and decrease of time of SaO2<92% in observation group were greater than those in control group (P<0.05). The changes of OSA-18 quality of life scores before and after treatment in the two groups showed the decreases of scores of sleep disorder, physical symptoms and daytime functional status and total score in observation group were greater than those in control group (P<0.05). In the mood, the guardian In terms of impact, there was no significant difference in the magnitude of the changes between the two groups (P>0.05). There were no significant differences in the scores of poor mood and impact on guardian between the two groups (P>0.05). The postoperative bleeding rate was 2.33% in observation group, and there were no serious complications in the two groups. Conclusion: Adenoid hypertrophy and tonsil hypertrophy are the main causes of OSAHS in children. Endoscopic surgical resection can significantly improve hypoxemia and enhance quality of life of children patients. And it is superior to non-surgical treatment, and it has few postoperative complications, and it is safe and reliable. 2019 Vol. 25 (8): 1308-1311 [Abstract] ( 108 ) HTML (1 KB)  PDF (1241 KB)  ( 293 ) 1312 Relationship between Serum IL-23 and IL-35 and Carotid Atherosclerotic Plaque Stability in Patients with Acute Cerebral Infarction WANG Lin, QI Li, HE Wei, et al DOI: 10.3969/j.issn.1006-6233.2019.08.021 Objective: To investigate the relationship between the serum levels of IL-23 and IL-35 and the stability of carotid atherosclerotic plaques in patients with acute cerebral infarction. Methods: 124 patients with acute cerebral infarction were divided into unstable plaque group, stable plaque group and non-plaque group according to the results of carotid ultrasonography, and 63 healthy people were selected as control group. Serum levels of IL-23 and IL-35 were compared in each group. Results: The level of serum IL-35 (18.8±6.7) ng/ml in the acute cerebral infarction group was significantly higher than that in the control group (8.7±4.1) ng/ml (P<0.01); the level of serum IL-23 (24.3±4.8) ng/ml in the acute cerebral infarction group was significantly higher than that in the control group (8.4+1.6) ng/ml (P<0.01). Academic significance (P<0.01). Serum IL-35 level (22.3±5.8) ng/ml in patients with unstable plaque was significantly higher than that in patients with stable plaque (15.3±1.6) ng/ml in patients with unstable plaque (P<0.01); serum IL-35 level (22.3±5.8) ng/ml and (15.3+1.6) ng/ml in patients with unstable plaque and patients with stable plaque were significantly higher than those in patients without plaque (10.7±4.1) ng/ml in patients with unstable plaque (P<0.01). The serum IL-23 level (36.9+6.4) ng/ml in unstable plaque group was significantly higher than that in stable plaque group (23.4±4.7) ng/ml (P<0.01); the serum IL-23 level (36.9±6.4) ng/ml and (23.4±4.7) ng/ml in unstable plaque group and stable plaque group were significantly higher than those in non-plaque group (11.4±1.6 ) ng/ml, the difference was statistically significant (P<0.01). Conclusion: The serum levels of IL-23 and IL-35 in patients with acute cerebral infarction may be related to the stability of carotid atherosclerotic plaque. 2019 Vol. 25 (8): 1312-1315 [Abstract] ( 149 ) HTML (1 KB)  PDF (1249 KB)  ( 230 ) 1316 Analysis of Quality of Life and Neutrotransmitter Tested by Encephalofluctuograph of Venlafaxine in the Treatment of Depression LIU Tao, et al DOI: 10.3969/j.issn.1006-6233.2019.08.022 Objective: Research the clinical efficacy , serological indexes and neutrotransmitter of Venlafaxine in the treatment of depression . Methods: Select 168 depression patients between October 2015 and January 2017 of our hospital , divided them into two groups called control group and research group randomly, the control group was taken fluoxetine , while research group was combined with Venlafaxine , compared the SF-36 score , HAMD score , serological indexes and neutrotransmitter factors of two groups before and after treatment .Results:The SF-36 score of two groups before treatment had no statistical difference(P>0.05),the SF-36 score of research group 4 weeks and 8 weeks after treatment were both much higher than control group , and had statistical difference(P<0.05),the SF-36 score of two groups 4 weeks and 8 weeks after treatment all had statistical difference with pre-treatment respectively(P<0.05).The HAMD score of two groups had no statistical difference(P>0.05),the HAMD score of research group 4 weeks and 8 weeks after treatment were both much higher than control group , and had statistical difference(P<0.05),the HAMD score of two groups 4 weeks and 8 weeks after treatment all had statistical difference with pre-treatment respectively(P<0.05).The serological indexes of two groups such as TNF-α、IL-1β、IL-6 had no statistical difference(P>0.05),the TNF-α、IL-1β、IL-6 of research group 4 weeks and 8 weeks after treatment were both much lower than control group , and had statistical difference(P<0.05),the TNF-α、IL-1β、IL-6 level of two groups 4 weeks and 8 weeks after treatment all had statistical difference with pre-treatment respectively(P<0.05).The neutrotransmitter indexes such as Glu、NE、Ach、DA、5-HT and GABA of two groups before treatment had no statistical difference(P>0.05),Glu level of research group 4 weeks and 8 weeks after treatment were both much lower than control group , NE、Ach、DA、5-HT and GABA levels of research group of 4 weeks and 8 weeks after treatment were all much higher than control group , and had statistical difference(P<0.05),Glu、NE、Ach、DA、5-HT and GABA levels of two groups of 4 weeks and 8 weeks after treatment had statistical difference with pre-treatment respectively(P<0.05).Conclusion:The function mechanism of Venlafaxine is related to the expression of cytokines and the regulation of neutrotransmitters ,and the effect is accurate , which can significantly improve the quality of life of patients and promote the alleviation of depression symptoms , and is worthy of clinical promotion. 2019 Vol. 25 (8): 1316-1320 [Abstract] ( 141 ) HTML (1 KB)  PDF (1249 KB)  ( 257 ) 1321 Expression Levels of Cyclic RNA ciRS-7 and EGFR in Endometrial Carcinoma AN Xin, et al DOI: 10.3969/j.issn.1006-6233.2019.08.023 Objective: To investigate the expressions and clinical significances of cyclic RNA ciRS-7 and epidermal growth factor receptor (EGFR) in endometrial cancer. Methods: 62 patients tissus with endometrial cancer who underwent surgical treatment in Handan First Hospital from July 2011 to May 2013 were studied, meanwhile, 60 normal endometrial tissues of hysteromyoma patients undergoing hysterectomy were collected as control group, real-time fluorescence quantitative polymerase chain reaction (qRT-PCR) was used to detected the expression levels of ciRS-7 and EGFR in all specimens, the correlation between the expressions of ciRS-7 and EGFR, and their relationships with clinicopathological characteristics and prognosis. Results: The expression levels of ciRS-7 and EGFR in the study group were significantly higher than those in the control group (P<0.05); the expression of ciRS-7 was not correlated with age and menopause (P>0.05), but with histological differentiation, pathological stage, myometrial invasion, and lymph node metastasis (P<0.05); the expression of EGFR was not related to age (P>0.05), but related to menopause, histological differentiation, pathological stage, myometrial invasion, and lymph node metastasis (P<0.05); the correlation analysis showed that there was a positive correlation between ciRS-7 and EGFR expression in endometrial cancer tissues (r = 0.875, P<0.001); the median survival time of patients with high expression of ciRS-7 was lower than that of patients with low expression (P<0.05), and the median survival time of patients with high expression of EGFR was lower than that of patients with low expression (P<0.05). Conclusion: The expressions of ciRS-7 and EGFR are high in endometrial cancer, they were positively correlated, and correlated with histological differentiation, pathological stage, myometrial invasion, lymph node metastasis, and prognosis, it is speculated that both of them can be used as potential biomarkers for prognostic evaluation of endometrial cancer. 2019 Vol. 25 (8): 1321-1324 [Abstract] ( 128 ) HTML (1 KB)  PDF (1501 KB)  ( 297 ) 1325 Comparison of Clinical Effects of Directional Neuroendoscopy with Hematoma Evacuation and Double Soft-channel Drainage in the Treatment of Hypertensive Intracerebral Hemorrhage HE Liming, LIU Baoguo, et al DOI: 10.3969/j.issn.1006-6233.2019.08.024 Objective: To compare the clinical efficacy of directional neuroendoscopy hematoma evacuation and double soft channel drilling drainage in the treatment of hypertensive intracerebral hemorrhage. Methods: Eighty-seven patients with hypertensive intracerebral hemorrhage admitted in our hospital from August 2016 to July 2018 were enrolled, according to a simple randomized grouping method, they were divided into in the observation group (45 cases) and the control group (42 cases) . The observation group was treated with a square body-guided neuroendoscopic hematoma evacuation, and the control group was treated with double soft-channel drilling. The clinical efficacy, the National Institutes of Health Stroke Scale (NIHSS), the Barthel Index, surgical indicators, inflammatory factor levels, and complications of the two groups was compared between the two groups. Results: The total clinical effective rate of the observation group was significantly higher than that of the control group (P<0.05). There was no significant difference in NIHSS score and Barthel index between the two groups (P>0.05). The NIHSS scores of the two groups were decreased after 15 days, 30 days after surgery and 3 months after surgery (P<0.05). Barthel The index showed an upward trend (P<0.05), but the NIHSS score of the observation group was always lower than that of the control group (P<0.05), and the Barthel index was always higher than the control group (P<0.05). There were significant differences in the interaction between the two groups, at different time points, between groups, and between different time points (P<0.05). The intraoperative blood loss and operation time of the observation group were significantly higher than those of the control group (P<0.05), and the hematoma clearance rate was significantly higher than that of the control group (P<0.05). There were no significant differences in the levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and high-sensitivity C-reactive protein (hs-CRP) between the two groups before surgery (P>0.05). After 7d, 15d and 30d, the levels of IL-6, TNF-α and hs-CRP in the two groups were decreased (P<0.05), but the observation group was always lower than the control group (P<0.05).There were significant differences in the interaction between the two groups, at different time points, between groups, and between different time points (P<0.05). There were no significant differences in postoperative rebleeding, pulmonary infection, hydrocephalus, intracranial infection, drainage tube obstruction, and intracranial gas accumulation between the two groups (P>0.05). Conclusion:Compared with double soft channel drilling and drainage for hypertensive cerebral hemorrhage, the treatment of hypertensive cerebral hemorrhage with directional neuroendoscopic hematoma evacuation has a higher hematoma clearance rate and is more effective in improving neurological function and daily living ability. The level of inflammatory factors, good clinical efficacy, and fewer complications contribute to the improvement of prognosis. 2019 Vol. 25 (8): 1325-1328 [Abstract] ( 118 ) HTML (1 KB)  PDF (1243 KB)  ( 254 ) 1329 Curative Efficacy of Milrinone Combined with Dopaminein Treatment of Chronic Heart Failure and Effects on CysC NT-proBNP IL-6 Levels LI Fei, HU Jun, FENG Qifan DOI: 10.3969/j.issn.1006-6233.2019.08.025 Objective: To study the curative efficacy of milrinone combined with dopaminein treatment of chronic heart failure and effects on Cystatin C(CysC), N-terminal B type natriuretic peptide precursor(NT-proBNP), interleukin-6(IL-6) levels. Methods: 65 patients of chronic heart failure who received therapy from June 2017 to September 2018 in our hospital were selected as research objects, they were divided into observation group (35 cases) and control group (30 cases) by simple random number table method. The control group was given routine treatment, while the observation group was given milrinone combined with dopamine without digitalis preparation, they were continuous treatment for 7d. The clinical efficacy, the changes of serum CysC, NT-proBNP, IL-6 and adverse reactions were compared between the two groups. Results: After treatment, the total effective rate in the observation group was significantly higher than those in the control group(P<0.05); there were significant differences in the interaction of left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF), serum CysC, NT-proBNP and IL-6 between groups at interblock·different time points(P<0.05); there were no adverse reactions such as abnormal liver and kidney function, abnormal blood and urine routine, and 1 case of ventricular premature contraction in the observation group. Conclusion: Milrinone combined with dopaminein is well for chronic heart failure, which can effectively reduce the expression of serum CysC, NT-proBNP and IL-6, the clinical application value is high. 2019 Vol. 25 (8): 1329-1332 [Abstract] ( 98 ) HTML (1 KB)  PDF (1244 KB)  ( 289 ) 1333 Curative Effect of Rabeprazole Combined with Droperitiazole Meretroxine in the Treatment of Patients with Chronic Atrophic Gastritis and its Effect on Serum sIL-2R MDA and G-17 WANG Jian, CHEN Zhitao, ZHOU Tingting, et al DOI: 10.3969/j.issn.1006-6233.2019.08.026 Objective: To observe the curative effect of rabeprazole combined with droperitiazole meretroxine in the treatment of patients with chronic atrophic gastritis and its effect on serum soluble interleukin-2 receptor (sIL -2R), malondialdehyde (MDA) and gastric secrete element-17 (G-17). Methods: 96 cases of chronic atrophic gastritis patients from December 2015 to December 2017, according to the simple random number table method these patients were divided into control group and research group,48 cases in each group. control group was treated with rabeprazole, and the research group was treated with flupipertiazol tablet united rabeprazole. Then curative effect, SF-36 scale score, anxiety, depression scores and symptom scores,sIL-2R,MDA,G-17, and adverse reactions occur between two group were and compared. Results: Total effective rate of the experimental group 95.83% was significantly higher than the control group 79.18% (P<0.05). Before treatment, SF-36 scale score, anxiety, depression scores and symptom scores,sIL-2R,MDA,G-17 of two group was no statistically significant (P>0.05). 2 weeks after treatment, 4 weeks after treatment, SF-36 scale score, G-17 of experimental group was significantly increased than after the treatment, the treatment group was significantly higher than the control group, anxiety depression scale and symptom scores, sIL-2R, MDA of two group was significantly reduced than after treatment, the experimental group was significantly lower than the control group,the difference was statistically significant (P<0.05). The adverse effects rate in both group was no statistical significance (P>0.05). Conclusion: curative effect of rabeprazole combined with droperitiazole meretroxine in the treatment of patients with chronic atrophic gastritis is sure, can significantly improve the clinical symptoms of patients,improve health,,it may be more conducive to regulating sIL-2R, MDA, and G-17 levels. 2019 Vol. 25 (8): 1333-1335 [Abstract] ( 119 ) HTML (1 KB)  PDF (1216 KB)  ( 237 ) 1336 Efficacy and Safety of Febuxostat Combination with Alprostadil in Treatment of Chronic Renal Failure and Influence Onhyperuricemia Andhemorheology LI Zhicheng, TANG Zhigang, ZHENG Qiao, et al DOI: 10.3969/j.issn.1006-6233.2019.08.027 Objective: To study the efficacy and safety of febuxostat combination withalprostadil in treatment of chronic renal failure and influence on hyperuricemia(UA) and hemorheology. Methods: 90 patients of chronic renal failure who received therapy from February 2015 to February 2018 in our hospital were selected as research objects,theywere divided into observation group (50 cases) and control group (40 cases) by simple random number table method,on the basis of routine treatment, the control group was treated with febuxostat, and the observation group was treated with Alprostadil for 8 weeks.The clinical efficacy, laboratory indexes, hemorheological changes and adverse reactions of the two groups were compared.Results: After treatment, the total effective rate of the observation group was significantly higher than those in the control group(P<0.05); there were significant differences in urea nitrogen (BUN), serum creatinine (Scr), 24-hour urinary protein, UA, whole blood high shear viscosity, whole blood low shear viscosity and plasma viscosity between groups at interblock·different time points(P<0.05);in the observation group, there were 2 cases of redness in the injection site during the intravenous injection of alprostadil, and there were no nausea and vomiting, obvious abnormal liver function, joint pain and other adverse reactions during the treatment of the two groups. Conclusion: Febuxostat combination withalprostadil is well for chronic renal failure, which can effectively improve blood hypercoagulability and renal function, reducing UA expression, and without increasing adverse drug reactions and has high clinical value. 2019 Vol. 25 (8): 1336-1339 [Abstract] ( 103 ) HTML (1 KB)  PDF (1216 KB)  ( 280 ) 1340 Application of Dexmedetomidine combined with Endotracheal Intubation Laryngeal Mask in Anesthesia for Patients with Cervical Spine Injury SUN Yanbin, et al DOI: 10.3969/j.issn.1006-6233.2019.08.028 Objective: To analyze the anesthesia effect of dexmedetomidine combined with ILMA in treating patients with cervical spine injury. Methods: 120 patients with cervical spine injury from December 2011 to December 2017 were randomly divided into control group and observation group, each group with 60 cases. The control group was treated with midazolam combined with ILMA, while observation group was treated with endotrachealintubation anesthesia combined with ILMA. The clinical indexes, changes of hemodynamic parameters and s tress hormone indexes of before anaesthesia (T0), 1 min after anaesthesia (T1), during intubation (T2) and 1 min after successful intubation(T3) of two groups were compared. Results: The total success rate of intub ation of the observation group and contr ol group was 96.67% and 91.67% respectively. There was no significant difference in the total success rate, intubation time and atropine use before intubation between the two groups (P>0.05). The success rate of the first intubatio n and tolerance rate in the observation group were significantly higher than those in the control group (P<0.05), The rate of use of esmolol and agitatio n after intubation were significantly lower than those of the control group (P<0.05). HR, MAP, SpO2 in the two groups at T0, T1, T2, T3 were decreased first and then increased, there was no significant difference in T0 between groups, but there was significant difference in T1, T2 and T3 (P<0.05), the fluctuation of the observation group was smaller and more stable; The Ramsay score of the two groups were increased first and then decreased, and the sedation state of the observation group was better than that of the control group; there was no significant difference in norepinephrine and epinephrine between the two groups at T0 and T1, while the observation group was significantly lower at T2 and T3 than the control group (P<0.05), the fluctuation of the observation group was smaller and more stable; The interaction effect of the above indexes between two groups at different time points, between groups, at different time, between groups and between groups had significant differences (P<0.05). Conclusion: Dexmedetomidine combined with ILMA can improve the success rate and tolerance of the first intubation of anesthesia in patients with cervical spine lesion, which is conducive to maintaining stable hemodynamics and alleviating the stress response of patients. 2019 Vol. 25 (8): 1340-1343 [Abstract] ( 107 ) HTML (1 KB)  PDF (1232 KB)  ( 361 ) 1344 Effect of Combined Nerve Block Anesthesia on Postoperative Analgesia and Immune Function in Elderly Patients Undergoing Total Hip Replacement SHI Yajuan DOI: 10.3969/j.issn.1006-6233.2019.08.029 Objective: To investigate the effect of combined nerve block anesthesia on postoperative analgesia and immune function in elderly patients undergoing total hip arthroplasty. Methords: 112 elderly patients treated in our hospital from 2013.1 to 2018.1 were selected for the study of total hip replacement. The patients were coded according to admission time. The patients were divided into experimental group and control group. Each group had 56 patients. The experimental group received combined nerve block anesthesia, while the control group received single general anesthesia. After operation, the analgesic effect and immune function of the two groups of elderly patients were compared. Results: The postoperative analgesic effect and immune function of the elderly patients in the experimental group were significantly better than those in the control group (P<0.05). However, there was no statistical difference in the immune function between the two groups before treatment (P>0.05). Conclusion: The effect of combined nerve block anesthesia on analgesia and immune function in elderly patients undergoing total hip arthroplasty is significantly better than that of single general anesthesia. Combined with nerve block anesthesia is more worthy of clinical recommendation. 2019 Vol. 25 (8): 1344-1347 [Abstract] ( 141 ) HTML (1 KB)  PDF (1215 KB)  ( 242 ) 1348 Study on Relationship between FeNO concentration with Pulmonary Function and Serum IL-17 IgE in Patients with Bronchial Asthma in Non-acute Episodes RONG Qing'na, ZHAO Xiaoling, LI Xia, et al DOI: 10.3969/j.issn.1006-6233.2019.08.030 Objective: To investigate the relationship between exhaled nitric oxide (FeNO) concentration with pulmonary function and serum interleukin-17 (IL-17) and immunoglobulin E (IgE) levels in patients with bronchial asthma in non-acute episodes. Methods: 125 patients with non-acute bronchial asthma were enrolled according to the Asthma Control Test (ACT) score: control group (40 cases), partial control group (45 cases), and uncontrolled group (40 cases). Another 40 patients with normal physical examination were selected as the control group. FeNO, lung function indexes and serum IL-17 and IgE were detected in several groups of subjects. The results of several groups were compared and the correlation between ACT scores and FeNO, lung function indicators, IL-17, and IgE was analyzed. Results: Compared with the control group, the level of FeNO in the experimental group was significantly higher, the levels of FEV1 and PEF were significantly lower (P<0.05); In the experimental group, compared with the uncontrolled group, the level of FeNO in the control group was significantly lower, the levels of FEV1 and PEF were significantly higher, and the level of FeNO in the control group was significantly lower, and the levels of FEV1 and PEF were significantly higher than those in the control group (P<0.05). The levels of FEV1 and PEF in some control group were close to those in uncontrolled group (P>0.05); the levels of IL-17 and IgE in the experimental group were significantly higher than those in the control group (P<0.05); the levels of IL-17 and IgE in the control group and some control group were significantly lower than those in the uncontrolled group, and the levels of IL-17 and IgE in the control group were significantly lower than those in the partial control group (P<0.05). FeNO concentration was not significantly correlated with FEV1 and PEF (P>0.05), but positively correlated with serum levels of IL-17 and IgE (P<0.05). Conclusion: FeNO in patients with bronchial asthma in non-acute episodes is closely related to serum IL-17 and IgE, but has no significant correlation with pulmonary function. FeNO combined with pulmonary function can comprehensively reflect asthma control in patients with bronchial asthma. 2019 Vol. 25 (8): 1348-1350 [Abstract] ( 104 ) HTML (1 KB)  PDF (1218 KB)  ( 285 ) 1351 Clinical Efficacy of Wenyang Yixin Principle combined with Western Medicine in the treatment of Congestive Heart Failure JING Yating, WANG Fengrong, LIU Yue DOI: 10.3969/j.issn.1006-6233.2019.08.031 Objective: To explore the clinical efficacy of Wenyang Yixin principle combined with western medicine in the treatment of congestive heart failure (CHF). Methods: 202 patients with CHF were selected and randomly grouped according to the random number table method. Control group was treated with conventional western medicine, and observation group was treated with Wenyang Yixin principle based on control group. The efficacy of cardiac function was evaluated in the two groups. TCM symptoms scores and TCM syndrome efficacy were compared between the two groups before treatment and after 16 w of treatment, and levels of cardiac ultrasound indicators and serum copeptin and N-terminal pro-brain natriuretic peptide (NT-proBNP) were observed in the two groups before treatment and after 16 w of treatment. Results: The total effective rate of cardiac function in observation group was significantly higher than that in control group (97.03% vs 87.13%). After treatment, the scores of TCM symptoms of palpitations, asthma, chest pain, edema of extremities, cough and expectoration and oliguria were significantly reduced in the two groups (P<0.05), and the changes in observation group were significantly greater than those in control group (P<0.05). The total effective rate of TCM syndromes in observation group was significantly higher than that in control group (90.10% vs 71.29%). After treatment, the cardiac ultrasound indicator left ventricular end-systolic diameter (LVESD) in the two groups was significantly decreased (P<0.05) while the left ventricular ejection fraction (LVEF), cardiac output (CO) and mitral anterior blood flow E-to-A ratio (E/A) were significantly increased (P<0.05), and the changes of other indicators except the LVESD in observation group were significantly greater than those in control group (P<0.05). After treatment, the levels of serum copeptin and NT-proBNP were significantly decreased in the two groups (P<0.05), and the declines in observation group were significantly greater than those in control group (P<0.05). Conclusions: Wenyang Yixin principle combined with western medicine has significant efficacy on CHF, and it can effectively improve cardiac function, alleviate the related symptoms of heart failure, regulate the levels of copeptin and NT-proBNP, and benefit the prognosis of patients. 2019 Vol. 25 (8): 1351-1355 [Abstract] ( 89 ) HTML (1 KB)  PDF (1257 KB)  ( 211 ) 1356 MRI Features of Placentas with Different Subtypes of Fetal Growth Restriction XIE Lehua, XU Haidong, LIU Yugui DOI: 10.3969/j.issn.1006-6233.2019.08.032 Objective: To analyze placenta MRI features of fetal growth restriction (FGR) with different subtypes, and to provide evidence for FGR treatment. Methods: The clinical data of 36 pregnant women diagnosed with FGR were collected as the FGR group. 30 normal pregnant women were selected as the control group. All patients underwent MRI diffusion-weighted imaging (DWI) examination. And they were divided into symmetrical group and asymmetrical group according to the head circumference/length. The placenta MRI features of FGR with different subtypes were compared. Results: The placental thickness and placental volume of symmetrical FGR group were lower than those of asymmetrical FGR group and the control group. The placental apparent diffusion coefficient (ADC) value was lower than that of the control group (P<0.05). The placental volume of asymmetrical FGR group was lower than that of the control group, and placental ADC value was lower than that of symmetrical FGR group and the control group (P<0.05). The head circumference, length and the Apgar scores at 1 min after birth of symmetrical FGR group were lower than those of asymmetrical FGR group and the control group (P<0.05), and the weight was lower than that of the control group (P<0.05). The length, weight and and the Apgar scores at 1 min after birth in asymmetrical FGR group were lower than those in the control group (P<0.05). Except the weight, the other indexes were higher than those in symmetrical FGR group (P<0.05). The incidence of perinatal complications in symmetrical FGR group was slightly higher than that in asymmetrical FGR group and the control group (P>0.05). Conclusion: The MRI of symmetrical FGR is characterized by low placental thickness, volume and ADC value. The placenta thickness is basically normal in asymmetrical FGR, and the decrease of placental volume is short of symmetrical type. But the decrease of ADC value is significant. 2019 Vol. 25 (8): 1356-1359 [Abstract] ( 122 ) HTML (1 KB)  PDF (2424 KB)  ( 325 ) 1360 Analysis on the Relationship between Resting Heart Rate and Metabolic Syndrome in Patients with Hypertension XU Dongdong, ZHAO Qiqin, BAI Zhifang DOI: 10.3969/j.issn.1006-6233.2019.08.033 Objective: To analyze the relationship between resting heart rate (RHR) and metabolic syndrome (MS) in patients with hypertension. Methods: A total of 126 patients with essential hypertension admitted to the hospital from December 2016 to December 2018 were included in the study. According to whether patients with hypertension were complicated with MS, they were divided into simple hypertension group (n=72), hypertension with 1 item MS group (n=31) and hypertension with MS group (n=23). Age, gender, history of hypertension, BMI, waist circumference, resting heart rate and laboratory biochemical indicators [including fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting insulin concentration (FINS), insulin resistance index (IR)] were compared among the three groups, and the risk factors affecting MS in hypertension were analyzed. Results: There were significant differences in the age, history of hypertension, BMI, waist circumference, RHR, FBG, TC, TG, HDL-C, LDL-C and IR among simple hypertension group, hypertension with 1 item MS group and hypertension with MS group (P<0.05), and there was no significant difference in the gender proportion among the three groups (P>0.05). Correlation analysis showed that RHR value was positively correlated with waist circumference, FBG, TG, LDL-C, FINS and IR in patients with hypertension (r=0.14, 0.13, 0.61, 0.45, 0.41, 0.54, 0.63, P<0.05). Logistic regression analysis suggested that waist circumference, RHR and IR were independent risk factors for hypertension with MS. Conclusions: Hypertensive patients with MS are closely related to IR, waist circumference and RHR. It is suggested that hypertensive patients exercise more to reduce abdominal fat and pay attention to regulating RHR, reduce insulin resistance index, so as to reduce the risk of cardiovascular disease. 2019 Vol. 25 (8): 1360-1362 [Abstract] ( 112 ) HTML (1 KB)  PDF (1216 KB)  ( 317 ) 1363 The Expression of PCSK9 in Patients with T2DM and Coronary Heart Disease and its Clinical Significance TANG Yuanyuan, WANG Xiaoshu DOI: 10.3969/j.issn.1006-6233.2019.08.034 Objective: To investigate the expression of serum Proprotein convertase subtilisin/kexin type 9 (PCSK9) in patients with type 2 diabetes mellitus (T2DM) complicated with coronary heart disease (CHD) and its clinical significance.Methods: 90 patients with T2DM who were treated in our hospital from January 2017 to June 2018 were enrolled,40 patients with CHD were included as T2DM combined with CHD group,another 50 patients with simple T2DM as T2DM group,another 40 healthy subjects were selected as the control group.The levels of serum PCSK9, glucose metabolism [Fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c) ,fasting insulin (FINS)], lipid metabolism [Total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C)]and inflammatory factors [Interleukin -6 (IL-6), homocysteine (Hcy) ,high sensitivity C reactive protein (hs-CRP)]were compared between the three groups,the correlation between serum PCSK9 levels and glucose metabolism index, lipid metabolism index and inflammatory factors in patients with T2DM and CHD were analyzed.Results: Serum PCSK9 levels in T2DM combined with CHD group were higher than that in T2DM group and control group (P<0.05).The levels of HbA1c and FINS in T2DM combined with CHD group were higher than those in T2DM group and control group, and FPG level was higher than that in control group (P<0.05).The levels of TC, TG and LDL-C in T2DM combined with CHD group were higher than those in T2DM group and control group, and HDL-C level was lower than that in control group (P<0.05).The levels of IL-6, Hcy and hs-CRP in T2DM combined with CHD group were higher than those in T2DM group and control group (P<0.05).Serum PCSK9 levels in patients with T2DM combined with CHD were positively correlated with FINS, TC, TG, LDL-C, IL-6, Hcy, hs-CRP (P<0.05), and had no significant correlation with FPG, HbA1c, HDL-C (P >0.05).Conclusion: Serum PCSK9 is highly expressed in patients with T2DM and CHD, and its expression level is positively correlated with FINS, TC, TG, LDL-C, IL-6, Hcy and hs-CRP. 2019 Vol. 25 (8): 1363-1367 [Abstract] ( 111 ) HTML (1 KB)  PDF (1233 KB)  ( 302 ) 1368 Comparative Analysis of Clinical Efficacy and Prognosis of Patients with Multiple Thyroid Nodules treated by Total Thyroidectomy and Subtotal Thyroidectomy WANG Naijin, YING Haojie, SHI Jin, et al DOI: 10.3969/j.issn.1006-6233.2019.08.035 Objective:To explore the clinical efficacy and prognosis effects of patients with multiple thyroid nodules treated by total thyroidectomy and subtotal thyroidectomy. Methods:Ninety patients with multiple thyroid nodules in our hospital from March 2016 to August 2017 were retrospectively analyzed. They were divided into total thyroidectomy group (n = 45) and subtotal thyroidectomy group (n = 45). Total thyroidectomy group was treated by total thyroidectomy, and subtotal thyroidectomy group was treated by subtotal thyroidectomy. The clinical efficacy and prognosis of the two groups were compared. Results:The operative time and total hospital stay in total thyroidectomy group were longer than those in subtotal thyroidectomy group, and the length of incision was longer than that in subtotal thyroidectomy group, and the usage amount of analgesics was more than that in subtotal thyroidectomy group (P<0.05). The postoperative thyroid function indexes of free triiodothyronine (FT3) and free thyroxine (FT4) in total thyroidectomy group were lower than those in subtotal thyroidectomy group (P<0.05). There was no statistically significant difference in parathyroid gland function indexes between the two groups before and after surgery (P>0.05). The incidence rate of complications in total thyroidectomy group was higher than that in subtotal thyroidectomy group (17.78% vs 4.44%) (P<0.05). At 1 year after operation,the recurrence rate of total resection group was lower than that of subtotal resection group, and the difference was statistically significant (P<0.05). Conclusions:Subtotal thyroidectomy for patients with multiple thyroid nodules has less damage to their thyroid function and lower incidence of complications, while total thyroidectomy for patients with multiple thyroid nodules has lower recurrence rate. Both methods have their own advantages 2019 Vol. 25 (8): 1368-1370 [Abstract] ( 129 ) HTML (1 KB)  PDF (1208 KB)  ( 233 ) 1371 Analysis on Efficacy of Cimetidine and Interferon combined with Zinc Supplement in treatment of Rotavirus Infectious Diarrhea in Children WANG Daoli, WANG Qian, HE Aling DOI: 10.3969/j.issn.1006-6233.2019.08.036 Objective: To study the application effects of cimetidine and interferon combined with zinc supplement in the treatment of rotavirus infectious diarrhea in children. Methods:180 children patients with rotavirus infectious diarrhea admitted to our hospital from January 2017 to January 2018 were randomly divided into observation group (cimetidine + interferon+zinc supplement, n=90) and control group (cimetidine+interferon, n=90). The treatment effects were observed in the two groups. Results:The stool recovery time, dehydration correction time and body temperature recovery time in observation group were significantly shorter than those in control group (P<0.05). After 3 d of treatment, the negative conversion rate of fecal rotavirus antigen in observation group was significantly higher than that in control group (P<0.05), and the effective rate of treatment was significantly better than that in control group (P<0.05). After 10 d of treatment, the blood zinc levels in the two groups were significantly higher than those before treatment (P<0.05), and the increase in observation group was significantly greater than that in control group (P<0.05), and the blood zinc level in observation group after treatment was significantly higher than that in control group (P<0.05). At 3 months of telephone follow-up, the recurrence rate was 8.89% in observation group and was 20.00% in control group, and there was a significant difference in the recurrence rate between the two groups (χ2=4.23, P<0.05). Conclusions: Zinc supplementation with cimetidine and interferon has a good application value in children with RV infectious diarrhea. It can alleviate the clinical symptoms of children in a short time, promote the negative reaction of RV antigen, improve the treatment effect and reduce the recurrence rate in later period. It is worthy of clinical promotion. 2019 Vol. 25 (8): 1371-1373 [Abstract] ( 89 ) HTML (1 KB)  PDF (1211 KB)  ( 223 ) 1374 Analysis on Effectiveness of Collagen Sponge in Preventing Postoperative Bleeding and Incision Adhesion in Thyroid Surgery QIU Lifei, SUN Qiyu, ZHAO Guojun DOI: 10.3969/j.issn.1006-6233.2019.08.037 Objective: To explore the effect of collagen sponge in preventing postoperative bleeding and incision adhesion after thyroidectomy. Methods: 98 patients with thyroid surgery, from October 2017 to June 2018, were randomly divided into two groups: observation group and control group. In the observation group, after resection of the lesion, the bleeding was completely stopped by ultrasonic scalpel and bipolar electrocoagulation forceps, and collagen sponge was placed between the surgical wound and anterior cervical muscle group. In the control group, collagen sponge was not placed after complete hemostasis with ultrasonic scalpel and bipolar electrocoagulation forceps. The drainage volume of negative pressure drainage tube and the adhesion of incision and blood oozing were observed after operation. Results: The negative pressure drainage volume of the observation group was 14.64±6.18 ml 24 hours after operation, which was lower than that of the control group (36.68±9.28 ml) , with difference statistically significant(p<0.05). The negative pressure drainage volume of the observation group was 38.10±7.29ml 48 hours after operation, which was lower than that of the control group (56.12±8.67ml) , with difference statistically significant(p<0.05). The incidence of blood seepage was 4.08 % in the post-operative group, which was lower than 16.33 % in the control group. The difference was statistically significant.(p<0.05); The synchronous neck movement rate of the observation group was 10.20%, three months after operation, which was significantly lower than that of the control group (26.53%), with difference statistically significant(p<0.05). Conclusion: The application of collagen sponge in thyroidectomy can effectively prevent postoperative bleeding and incision adhesion, reduce the risk of postoperative bleeding, reduce the incidence of incision adhesion, and has good clinical application value. 2019 Vol. 25 (8): 1374-1376 [Abstract] ( 125 ) HTML (1 KB)  PDF (1216 KB)  ( 264 ) 1377 Correlation between Survivin Acetylation and PCAF, P300 Expression in Esophageal Carcinoma and its Clinical Significance ZHAO Baozhong, et al DOI: 10.3969/j.issn.1006-6233.2019.08.038 Objective: To investigate the relationship between the acetylation level of Survivin protein and the expression of PCAF,P300 and the clinical features of esophageal carcinoma. Methods: The Survivin protein acetylation level were examined via co-immunoprecipitation experiment in 70 cases esophageal carcinoma tissue and peficancerous tissues. The PCAF and P300 protein were examined via Immunohistochemical staining experiment in esophageal carcinoma tissue.The relationship was analyzed between Survivin acetylation level and expression of PCAF, P300 and clinical case characteristics. Results: (1)The Survivin protein was acetylated in esophageal carcinoma tissue. The Survivin protein acetylation level in esophageal carcinoma tissue was 72.05±1.26%, it was obviously higher than the peficancerous tissues(13.03±1.34%). There was statistics difference (P<0.05);The Survivin protein acetylation level were closely related to esophageal carcinoma staging, differentiation and lymph node metastasis (P<0.05); (2) The positive expression of PCAF was 38.57% in cancer tissues,which was lower than that in normal tissues which was 87.14%. There was statistics difference (P<0.05); (3) The positive expression of P300 was 72.86%% in cancer tissues,which was higher than that in normal tissues which was 15.71%%. There was statistics difference (P<0.05); (4)The Survivin acetylation level and expression of PCAF in esophageal carcinoma was no correlation.The correlation coefficient r=0.2421 (P>0. 05);(5)The Survivin acetylation level and expression of P300 in esophageal carcinoma was interrelated.The correlation coefficient r=0.7453 (P<0. 05). Conclusions: Survivin protein acetylated in esophageal cancer tissue, and the occurrence and development of esophageal cancer may be closely related to the degree of acetylation of Survivin protein. The acetylation of Survivin protein was correlated with acetyltransferase P300, but not with PCAF. 2019 Vol. 25 (8): 1377-1379 [Abstract] ( 158 ) HTML (1 KB)  PDF (1354 KB)  ( 298 ) 1380 Analysis on Efficacy and Safety of Conformal Intensity-modulated Radiotherapy combined with Targeted Therapy in the treatment of Brain Metastases from Lung Cancer RAO Jian, ZHANG Qinhua, LIN Xiuxin, et al DOI: 10.3969/j.issn.1006-6233.2019.08.039 Objective: To explore the efficacy and safety of conformal intensity-modulated radiotherapy combined with targeted therapy in the treatment of brain metastases from lung cancer. Methods: 82 patients with brain metastases from lung cancer admitted to hospital from January 2012 to June 2017 were selected and divided into control group and observation group according to the random number table method, with 41 cases in each group. Control group was given conformal intensity-modulated radiotherapy combined with chemotherapy, and observation group was given conformal intensity-modulated radiotherapy combined with targeted therapy. The serum levels of tumor indexes factors were detected by ELISA. The serum levels of tumor indexes factors, efficacy, adverse reactions and 1-year survival rate were observed and compared between the two groups. Results: The total effective rate in observation group was significantly higher than that in control group (92.68% vs 70.73%) (χ2=6.609, P=0.010). The serum levels of TNF-α, NSE, SCC-Ag and CEA in observation group were significantly lower than those in control group (t=5.122, 13.013, 13.416, 22.857, P=0.000, 0.000, 0.000, 0.000). There was no significant difference in the incidence rate of adverse reactions between the two groups after treatment (P>0.05), and they were tolerated. The 1-year PFSand 1-year OS were 63.42% and 68.29% in observation group, which were significantly higher than those in control group with 36.56% and 46.34% (Log-rank χ2=6.874, 4.797, P=0.008, 0.029). Conclusions: Intensity modulated radiation therapy (IMRT) combined with targeted therapy can be used for symptomatic patients with brain metastases from lung cancer. The clinical efficacy is significantly better than that of radiotherapy and chemotherapy, and the side effects are tolerable. 2019 Vol. 25 (8): 1380-1383 [Abstract] ( 126 ) HTML (1 KB)  PDF (1329 KB)  ( 295 ) 1384 Analysis on the Efficacy and Safety of Bevacizumab Combined with Chemotherapy in treatment of Platinum Sensitive Recurrent Ovarian Cancer JIANG Fan, GAO Yang, REN Xiaochen, et al DOI: 10.3969/j.issn.1006-6233.2019.08.040 Objective: To investigate the clinical efficacy and safety of Bevacizumab combined with chemotherapy in treatment of platinum sensitive recurrent ovarian cancer, and provide a certain reference for clinical treatment. Methods: 80 patients with platinum sensitive recurrent ovarian cancer selected from February 2015 to February 2018, and they were divided into control group and experimental group, which were treated with conventional therapy and bevacizumab combined treatment. After a period of treatment, the clinical efficacy, KPS score and adverse reaction of the two groups were observed. Results: There was no significant difference in cancer control rate between the experimental group and the control group, but the difference of the cancer remission rate was statistically significant (P<0.05). The rate of cancer remission in the experimental group was higher than that of the control group. And there was no significant difference in the adverse reaction of the two groups. The KPS score of the experimental group was higher than that of the control group. The difference was statistically significant (P<0.05). Conclusion: Bevacizumab combined with chemotherapy has certain clinical curative effect in treating platinum sensitive recurrent ovarian cancer, and the patient is well tolerated, so it has certain clinical reference value. 2019 Vol. 25 (8): 1384-1386 [Abstract] ( 133 ) HTML (1 KB)  PDF (1219 KB)  ( 240 ) 1387 Analysis of Nosocomial Infections and Pathogens in Patients with Undergoing Abdominal Surgery in 2017 HU Jiuli, TANG Guanjie, XIAO Xu, et al DOI: 10.3969/j.issn.1006-6233.2019.08.041 Objective: To analyze the infection site, pathogens and drug resistance of patients with nosocomial infection in undergoing abdominal surgery, so as to provide evidence for the prevention and treatment of nosocomial infections. Methods: Retrospective analysis of 47 cases of hospital infection patients with 576 hospitalized patients in our hospital in 2017 The clinical data explored the types of surgery in hospital infections, the distribution and composition ratio of nosocomial infections, and the distribution and drug resistance of nosocomial infections. Results: In the surgical patients, nosocomial infection occurred mainly in Ⅱ incision surgery (78.72%) in 47 cases, the proportion of infections in the incision site was the highest (63.27%), followed by respiratory infection (24.49%), and the other was catheter Correlation of infection; The submission rate of the pathogens causing the nosocomial infection reached 74.00%, of which the detection rate was 59.09%, of which the blood sample was the lowest; 26 cases of pathogens were isolated, including 12 cases of Gram-negative bacteria, Gram 5 cases of positive bacteria and 3 cases of fungi.Conclusion: The main infection sites of abdominal emergency surgery hospital infection, the analysis of infectious pathogens, to minimize the incidence of nosocomial infection, and provide a basis for the standard selection of antibacterial drugs, to achieve effective prevention and control the purpose of hospital infection. 2019 Vol. 25 (8): 1387-1389 [Abstract] ( 89 ) HTML (1 KB)  PDF (1372 KB)  ( 249 ) 1390 Effect of Dexmedetomidine on Analgesia and Intestinal Function after Radical Resection of Colon Cancer AN Bin, LIU Shuo, TAO Deqiang DOI: 10.3969/j.issn.1006-6233.2019.08.042 Objective: To study the effect of dexmedetomidine on analgesia and intestinal function after radical resection of colon cancer. Methods: 80 patients with colon cancer underwent radical operation in our hospital from March 2017 to March 2018 were selected. According to simple random number table, the patients were divided into observation group (45 cases) and control group (35 cases). According to simple random number table,those patients were divided into the observation group (n=45) and the control group (n=38). The control group was injected with normal saline before induction of general anesthesia, while the observation group was injected with dexmedetomidine. Then the surgical recovery index (recovery time, first exhaust time, recovery time of spontaneous breathing, time of eating common food, recovery time of bowel sounds), Visual Analogue Scale/Score at 1 hour, 3 hours, 6 hours, 12 hours, 24 hours after operation, Systolic pressure, diastolic blood pressure, mean artery pressure levels before operation, immediately after intubation, immediately after extubation, immediately after extubation, incidence of adverse reactions of two groups before and after treatment were compared. Results: The Recovery time, first exhaust time, recovery time of spontaneous breathing, common food intake time, recovery time of bowel sounds in the observation group were significantly lower than those in the control group(P＜0.05). Postoperative 1H, postoperative 3h, postoperative 6h, postoperative 12h and postoperative 24hVAS scores were significantly lower than those of the control group(P＜0.05).Preoperative, intubation, immediate and immediate extubation of SBP, DBP and MAP were significantly lower than those of the control group(P＜0.05).The total incidence of adverse reactions was significantly lower than that of the control group[15.55%(7/45)vs34.21％(13/38)](P＜0.05). Conclusion: . Dexmedetomidine has remarkable analgesic effect after radical resection of colon cancer. It can improve analgesic and sedative effect, reduce fluctuation of vital signs, promote faster recovery of gastrointestinal function and reduce adverse reactions. 2019 Vol. 25 (8): 1390-1393 [Abstract] ( 92 ) HTML (1 KB)  PDF (1226 KB)  ( 256 ) 1394 Application of Colposcopy and Endocervical Scraping in the Diagnosis of HSIL YIN Donghui, SUN Yunxia, YANG Jie DOI: 10.3969/j.issn.1006-6233.2019.08.043 Objective: To study the value of colposcopy and endocervical curettage in the diagnosis of high-grade cervical lesions (HSIL). Methods: 68 suspected HSIL patients from January 2017 to January 2018 were selected from outpatient clinic of our hospital,all performed colposcopy and endocervical scraping, the pathological results of the hysterectomy were the gold standard. To analyze the value of colposcopy and endocervical scraping in the diagnosis of cervical intraepithelial neoplasia (CIN). Results: 16 cases of CINI lesions, 24 cases of CINII lesions, 18 cases of CINIII lesions and 10 cases of invasive cancer lesions were diagnosed by postoperative lesions. 10 cases of CINI lesions, 20 cases of CINII lesions, 22 cases of CINIII lesions and 6 cases of invasive cancer were diagnosed by colposcopy and endotracheal curettage. The coincidence rate between colposcopy and endoscopic scraping was 73.53% (50/68), and non-conformity was 26.47% (18/68), of which were over-diagnosed 5.88%(4/68), under-diagnosed 20.59% (14/68). colposcopy examination and neck lining scrape intraoperative and postoperative pathology of CIN Ⅰ, CIN Ⅱ, CIN Ⅲ and invasive cancer diagnosis is no statistical difference (P>0.05). Conclusion: Colposcopic examination and endocervical curettage are important means to prevent and treat cervical cancer, which can increase the accuracy of pathological biopsy to a certain extent and provide reliable basis for clinical treatment 2019 Vol. 25 (8): 1394-1396 [Abstract] ( 116 ) HTML (1 KB)  PDF (1218 KB)  ( 378 ) 1397 Analysis on Prognosis and Influencing Factors in Patients with Type 1 Cardiorenal syndRome Undergoing CRRT GAO Qingbao, DAI Ximing, CHEN Peng, et al DOI: 10.3969/j.issn.1006-6233.2019.08.044 Objective: To study the continuous renal replacement therapy (CRRT) in patients with kidney syndrome (CRS) 1 core and analyzes the factors affecting prognosis. Methods: 66 patients with type 1 cardiorenal syndrome admitted to our hospital from July 2017 to September 2018 were retrospectively collected. According to the death during hospitalization, 31 cases were divided into survival group and 35 cases into death group. The clinical indicators, laboratory examination indicators, treatment parameters and left ventricular ejection fraction levels of the two groups were compared, and multivariate logistic regression analysis was made. Results: The interval between diagnosis and treatment in survival group was (3.2 +0.8) days, which was lower than that in death group (5.1 +1.2) days, with significant difference (P<0.05). The levels of alanine aminotransferase, total bilirubin and serum creatinine in survival group were lower than those in death group, and there were significant differences (all P<0.05). The left ventricular ejection fraction of survival group was (60.4 +10.3)%, which was higher than that of control group (50.7 +9.2)%. The difference was significant (P<0.05). Multivariate logistic regression analysis showed that the interval between diagnosis and treatment was a risk factor for death in CRRT patients with type 1 cardiorenal syndrome, while left ventricular ejection fraction was a protective factor. Conclusion: CRRT has a poor prognosis for type 1 CRS patients. The interval between diagnosis and treatment is an independent risk factor for death, while left ventricular ejection fraction is a protective factor. 2019 Vol. 25 (8): 1397-1400 [Abstract] ( 97 ) HTML (1 KB)  PDF (1209 KB)  ( 255 ) 1405 Therapeutic Effect of Sanren Decoction and Ermiao Powder combined with Western Medicine on Dry Eye of Yin Deficiency and Dampness XU Ting, YANG Liying, GUO Tiezhu DOI: 10.3969/j.issn.1006-6233.2019.08.046 Objective:To observe the efficacy of addition and subtraction of Sanren decoction and Ermiao powder combined with western medicine in the treatment of yin deficiency and dampnesstype of xerophthalmia. Methods:82 patients (164 eyes) with xerophthalmia admitted to our hospital from June 2016 to December 2018 were selected. According to the random number table method, the patients were divided into observation group and control group, with 41 cases (82 eyes) in each group. Control group was given sodium hyaluronate eye drops for external use, and observation group was given addition and subtraction of Sanren decoction and Ermiao powder orally on the basis of control group. After 1 month of treatment, the TCM syndromes scores and efficacy index, objective indicators [Schirmer I test (SIt), break-up time (BUT) of tear film, corneal fluorescein staining (FL)], visual parameters [Strehl ratio (SR), objective scatter index (OSI)] and clinical efficacy were compared between the two groups after 1 month of treatment. Results: After 1 month of treatment, the symptoms scores in observation group were significantly lower than those in control group (P<0.05), and the SIt and BUT in observation group were significantly higher than those in control group while the FL was significantly lower than that in control group (P<0.05), and the SR was significantly higher than that in control group while the OSI was significantly lower than that in control group (P<0.05), and the differences of symptoms scores, SIt, BUT, FL, SR and OSI before and after treatment in observation group were greater than those in control group (P<0.05). The total effective rate in observation group was significantly higher than that in control group (95.12% vs 74.39%) (P<0.05). Conclusions:Sanren Decoction and Ermiao Powder combined with western medicine can better alleviate the symptoms of traditional Chinese medicine, improve the stability of tear film and visual quality, and improve the clinical efficacy. 2019 Vol. 25 (8): 1405-1408 [Abstract] ( 202 ) HTML (1 KB)  PDF (1220 KB)  ( 526 )

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