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2018 Vol. 24, No. 3
Published: 2018-03-31
 
353 The Relationship between the Expression of A and B and the Degree of Differentiation and Subtypes of Breast Cancer
ZHAO Wenming, ZHOU Bingjuan, LI Jinmei, et al
DOI: 10.3969/j.issn.1006-6233.2018.03.001
Objective: To investigate the relationship between the expression of -1 - alpha (HIF-1-α), glucose transporter 1 (Glut-1) and the degree of differentiation and molecular subtypes of breast cancer. Methods: Immunohistochemical method was used to detect the expression of HIF-1α and Glut-1 in 102 cases of breast cancer and 60 cases of adjacent normal tissues. The expression rates of HIF-1α and Glut-1 in breast cancer tissues with different degree of differentiation and molecular typing were compared. Results: The positive expression rates of HIF-1α and Glut-1 protein in breast cancer tissues were 62.75% and 68.63%, respectively, which were higher than those in 11.67% normal tissues. The difference was statistically significant (P < 0.05). The positive expression rates of HIF-1α and Glut-1 protein in high differentiated breast cancer tissues were 34.78% and 40.91%, respectively, which were lower than those of moderately differentiated 60%, 68.88%, and poorly differentiated 85.29% and 88.24% (P < 0.025). The differentiation of moderately differentiated breast cancer was lower than that of poorly differentiated ones (P < 0.025). There was no significant difference in positive expression rates of HIF-1α and Glut-1 protein between Luminal A type breast caner and Luminal B type breast caner (46.67% and 51.11% vs 54.55% and 63.64%) (P > 0.017). However, the rates in Luminal A and Luminal B type breast cancer were all lower than those in tissues with over-expressed HER-2 (85.71%, 92.86%) and triple negative breast cancer (90.48% and 95.24%) (P < 0.017). There was no significant difference between HER-2 overexpression type and three yin type (P > 0.017). Conclusion: The expression of HIF-1α and Glut-1 in breast cancer patients is highly positive, and the positive expression of HIF-1 alpha and Glut-1 in different degree of differentiation and molecular subtype of breast cancer is different.
2018 Vol. 24 (3): 353-357 [Abstract] ( 101 ) HTML (1 KB)  PDF (1345 KB)  ( 233 )
357 The Relationship between the Expression Level of Tumor Tissue and Plasma miR-146a and the Clinicopathological Features and Prognosis of Patients with Intrahepatic Cholangiocarcinoma
ZOU Yong, YU Changwen
DOI: 10.3969/j.issn.1006-6233.2018.03.002
Objective: To evaluate the association of circulating and tumor tissue miR-146a expressions with the clinicopathological properties and their correlations with prognosis in surgical patients with intrahepatic cholangiocarcinoma (ICC). Methods: 66 ICC patients were enrolled in the study. ICC tissues sample and plasma sample before operation were collected. The expression of miR-146a was determined by quantitative polymerase chain reaction (qPCR). Results: MiR-146a expressions in plasma were positively associated with that in tumor tissue (R=0.342, P=0.005). Tissue miR-146a was negatively correlated with poor differentiation (R=-0.253, P=0.041), TNM stage (R=-0.316, P=0.010), as well as ECOG performance (R=-0.386, P=0.001), while plasma miR-146a was inversely associated with N stage (R=-0.251, P=0.042) and TNM stage (R=-0.282, P=0.022). Kaplan-Meier curves suggested that high expression of tissue miR-146a was correlated with prolonged overall survival (OS) (P<0.001), while plasma miR-146a didn't (P=0.061). For the purpose of evaluating the prognostic value of tumor tissue or plasma miR-146a for NSCLC patients, univariate Cox regression analysis was performed, which indicated that tissue miR-146a could predict better OS (P<0.001); ECOG high performance (P=0.036), T high stage (P=0.005), N high stage (P=0.032), M high stage (P=0.006), and TNM high stage (P=0.019) could predict worse OS. Furthermore, multivariate Cox regression analysis revealed that only tissue miR-146a high expression was an independent factor for prolonged OS (P=0.001), while T high stage was a risk factor for OS. Conclusion: The expression level of miR-146a in tumor tissue and plasma is correlated with the clinicopathological characteristics of ICC patients, and miR-146a in tumor tissue may serve as a credible prognostic marker for ICC patients.
2018 Vol. 24 (3): 357-362 [Abstract] ( 68 ) HTML (1 KB)  PDF (1469 KB)  ( 155 )
362 Expression and Clinical Significance of miR-381 in Tissues of Esophageal Carcinoma
YANG Zebo, ZHANG Yuanyuan, TAO Kaiyi, et al
DOI: 10.3969/j.issn.1006-6233.2018.03.003
Objective: To investigate the expression of miR-381 in tissues of esophageal cancer and its clinical significance. Methods: 108 cases of esophageal cancer admitted to our hospital were selected as the research object, and the QRT-PCR method was used to detect the expression of miR-381 in postoperative cancer tissues and adjacent normal tissues.Analyzed the relationship between the expression of miR-381 and the clinicopathological features of esophageal cancer patients. Results: The expression of miR-381 in esophageal cancer tissues was significantly lower than that in adjacent normal tissues (0.47 ± 0.22 vs 1.02 ± 0.97),and the difference was statistically significant (P <0.05). The expression level of miR-381 in esophageal cancer was closely related to the TNM staging, differentiation degree, infiltration degree and lymph node metastasis (P <0.05), and the expression level of miR-381 in esophageal cancer tissues had no significant correlation with clinicopathological features such as gender, age, tumor diameter and tumor location (P> 0.05). Conclusions: MiR-381 in esophageal cancer is low expression, and its expression level is closely related to the occurrence and development of esophageal cancer, miR-381 may be a potential biomarker for the diagnosis of esophageal cancer and a new therapeutic target.
2018 Vol. 24 (3): 362-365 [Abstract] ( 64 ) HTML (1 KB)  PDF (1297 KB)  ( 104 )
366 The Value of SWE Combined with BI-RADS Grading in the Differential Diagnosis of Breast Masses and the Relationship with Pathological Features
YUAN Changhe, WEI Jie
DOI: 10.3969/j.issn.1006-6233.2018.03.004
Objective: To explore the value of shear wave elastography (SWE) combined with breast imaging reporting and data system (BI-RADS) grading in the differential diagnosis of breast masses and its relationship with pathological features. Methods: 96 patients with breast masses were examined by conventional breast ultrasonography and SWE, and the BI-RADS grading and modified SWE scoring were performed. With the diagnostic results of pathology as the golden standard, the diagnostic efficiency of BI-RADS grading and its combination with SWE in the differential diagnosis of breast masses was evaluated by the area under receiver operating characteristic (ROC) curve (AUC). The strain ratio of ultrasonic elastography of normal tissues and mass tissues was measured by SWE, and its relationship with pathological features was analyzed. Results: In the 96 patients, there were benign and malignant masses in 67 cases and 29 cases respectively diagnosed by pathology. There were statistically significant differences of BI-RADS grade and SWE score between benign and malignant masses (P < 0.05). The ROC curve showed that the AUC of BI-RADS grading and SWE combined with BI-RADS grading in the differential diagnosis of breast masses were 0.83 and 0.91 respectively. The specificity, positive predictive value, negative predictive value of SWE combined with BI-RADS grading in the diagnosis of benign and malignant breast masses were significantly higher than those of BI-RADS grading alone. In the 96 patients, the strain ratio of ultrasonic elastography was lower than 3.08 in 68 cases and more than 3.08 in 28 cases, with statistically significant differences between the two in the shape of masses, boundary, aspect ratio, echo, calcification, blood flow and other pathological features (P < 0.05). Logistic regression and multivariate analysis showed that shape of masses, boundary, aspect ratio, echo, calcification and blood flow were independent influencing factors of elasticity strain ratio larger than 3.08 (P < 0.05). Conclusion: SWE combined with BI-RADS grading can fully display the histological and pathological features of breast masses, which is helpful for the differential diagnosis of benign and malignant breast masses.
2018 Vol. 24 (3): 366-370 [Abstract] ( 93 ) HTML (1 KB)  PDF (1339 KB)  ( 429 )
370 Clinical Effect of Unilateral Approach Spinal Canal EnlargementAngioplasty in the Treatment of Degenerative Lumbar Spinal Stenosis under Endoscopic Microendoscopy
REN Mingliang, LI Hui, LIU Dongbin, et al
DOI: 10.3969/j.issn.1006-6233.2018.03.005
Objective: To investigate the clinical effect of unilateral approach spinal canal enlargement angioplasty in the treatment of degenerative lumbar spinal stenosis under endoscopy. Methods: 100 patients with degenerative lumbar spinal stenosis admitted from January 2014 to December 2016 were randomly divided into two groups. Patients in the control group were given non-surgical symptomatic treatment, while patients in the experimental group were treated with microscopic endoscopy spinal canal enlargement angioplasty. pain, lumbar function, neurological function recovery, disease-related parameters and quality of life were compared between the two groups. Results: The JOA score, ASIA score, FIM score, lordosis angle, lumbosacral angle, distance traveled, intervertebral space height, spinal canal sagittal diameter, physiological function and other quality of life indicators and overall health score were significantly higher in the operation group. The ODI score of the operation group was significantly lower than that of the control group, there was a significant difference (P <0.05). Conclusion: The clinical effect of unilateral approach spinal canal enlargement angioplasty under the endoscope for the treatment of degenerative lumbar spinal stenosis is significant and has reference value.
2018 Vol. 24 (3): 370-374 [Abstract] ( 68 ) HTML (1 KB)  PDF (1336 KB)  ( 165 )
374 Effect of Splenectomy and Pericardial Devascularization in the Treatment of Hepatocirrhosis with Portal Hypertension and the Influence on Liver Function of Patients
XIE Xiang, et al
DOI: 10.3969/j.issn.1006-6233.2018.03.006
Objective: To explore the effect of splenectomy and pericardial devascularization in the treatment of portal hypertension with liver cirrhosis and its effect on liver function in patients. Methods: A total of 78 patients with portal hypertension were treated in our hospital from March 2016 to May 2017. All the patients were divided into two groups according to random number table, each group of 39 cases. The patients in the control group were treated with traditional open splenectomy and pericardial devascularization. And the patients in the observation group were treated with laparoscopic splenectomy and pericardial devascularization. The clinical indicators, liver function indexes and complications were compared between the two groups. Results: The intraoperative blood loss, visual analogue scale (VAS) score, bowel function recovery time and hospitalization time were less in the observation group, and the operation time was longer and the difference was statistically significant(P <0.05).There was no significant difference in the levels of prothrombin time (PT), albumin (ALB), alanine aminotransferase (ALT) and total bilirubin (TBIL) between the two groups before operation (P> 0.05).The levels of PT, ALB, ALT and TBIL in the two groups were significantly better than those before operation (P <0.05).The levels of PT, ALT and TBIL in the observation group were significantly higher than those in the control group, the ALB level was lower (P <0.05).The incidence of postoperative complications was 5.13% (2/39) in the observation group significantly higher than that in the control group (23.08%, 9/39), the difference was statistically significant (P <0.05). Conclusion: Laparoscopic resection of pericardial cardiomyocytes can reduce the amount of intraoperative blood loss, reduce the incidence of complications, shorten the recovery time and hospital stay in patients with cirrhotic portal hypertension, improve liver function.
2018 Vol. 24 (3): 374-378 [Abstract] ( 63 ) HTML (1 KB)  PDF (1338 KB)  ( 141 )
378 Effects of High-dose Vitamin E Plus Ultra-heparin on Oxidative Stress and Microinflammatory state in Children with Henoch-schonlein Purpura
ZHU Li
DOI: 10.3969/j.issn.1006-6233.2018.03.007
Objective: To study the effects of high dose of vitamin E plus ultra - micro - heparin on oxidative stress and microinflammatory state in children with henoch-schonlein purpura. Methods: 114 children with Henoch-Schonlein purpura were enrolled in this study from August 2012 to January 2016. All children were divided into control group (n = 57 cases) and study group (n = 57 cases) according to the digital table method. The control group of children with conventional treatment of allergic purpura method, the study group of children in the control group based on the use of large doses of vitamin E and ultra-micro heparin. Results: After treatment, all the indexes of the study group decreased significantly (P <0.05), and there was significant difference between the two groups (P <0.05). All patients had no obvious abnormality of coagulation time, bleeding time and platelet count before and after treatment, and all children treated with heparin had no severe allergic reaction and side effects. All the children's blood lipids, Hb, ALB, etc. were no significant abnormalities, all large doses of vitamin E in children with no significant thrombosis, bleeding and other side effects. The total effective rate in the control group was 78.9%, significantly lower than the total effective rate of the study group was 96.5% (P <0.05). In the control group, 14 out of 57 patients had nephritis and the incidence of HSPN was 24.6%. In the study group, 4 patients had nephritis, and the incidence of HSPN was 7.0%. The incidence of HSPN in the control group was significantly higher than that in the study group (χ2 = 5.377, P <0.05). Conclusion: The synergistic effect of ultra-micro-heparin plus high dose of vitamin E on different pathogenesis of HSP can significantly reduce the incidence of HSP nephropathy and improve the micro-inflammatory state and oxidative stress state of HSP.
2018 Vol. 24 (3): 378-382 [Abstract] ( 71 ) HTML (1 KB)  PDF (1341 KB)  ( 243 )
382 Effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on the Inflammatory Factors of Severe Burn Patients and the Prevention of Sepsis
LIN Yan, RUAN Shubin, CHEN Xiaodong, et al
DOI: 10.3969/j.issn.1006-6233.2018.03.008
Objective: To investigate the effect of ligustrazine injection on inflammatory cytokines in severe burn patients and the prevention of sepsis. Methods: 80 patients with severe burn admitted to our hospital from April 2013 to March 2017 were randomly divided into two groups. Patients in the control group were given routine treatment. Patients in the observation group were treated with ligustrazine injection. The two groups of patients with inflammatory factors, other diseases related parameters and sepsis prevention effect were compared. Results: The levels of TNF-α, IL-1, IL-6, CRP and PCT in the observation group were significantly lower than those in the control group on the 1st, 3rd, 7th, 10th and 14th day after treatment. ALT and AST levels were significantly lower than the control group, there was a significant difference (P <0.05); SIRS incidence was significantly lower than the control group, there was a significant difference (P <0.05). Conclusion: The effect of Salviae Miltiorrhizae injection on inflammatory factors and prevention of sepsis in patients with severe burn has significant reference value.
2018 Vol. 24 (3): 382-385 [Abstract] ( 65 ) HTML (1 KB)  PDF (2542 KB)  ( 194 )
385 Effect of Paclitaxel Combined with Platinum Neoadjuvant Chemotherapy on Locally Advanced Cervical Cancer and the Influence on the Expression of Smac Survivin and MMP-2
ZHANG Zhian, YI Hongyan
DOI: 10.3969/j.issn.1006-6233.2018.03.009
Objective: To explore the clinical effect of paclitaxel combined with platinum neoadjuvant chemotherapy (NACT) in the treatment of locally advanced cervical cancer (LACC) and the influence on the expression of second mitochondria-derived activator of caspase (Smac), apoptosis inhibiting gene (Survivin) and matrix metalloproteinase -2 (MMP-2). Methods: 76 patients with LACC were divided into the study group and the control group by random number table method, 38 cases in each group. Patients in the study group were treated with paclitaxel + cisplatin chemotherapy, while patients in the control group were treated with cisplatin +5- fluorouracil (5-FU) chemotherapy. The short-term curative effect, operation indexes, postoperative lymph node metastasis and the expression of Smac in cervical cancer tissues were compared between the two groups. Changes of serum levels of Survivin and MMP-2 levels before and after treatment were observed, and the incidence of toxic and side reactions was recorded. Results: The response rate of the study group was higher than that of the control group. The operation time, intraoperative blood loss, postoperative lymph node metastasis rate and the positive rate of Smac in the cervical cancer tissues in the study group were shorter / less / lower than those in the control group (P < 0.05). After 2 courses of chemotherapy, serum levels of Survivin and MMP-2 in the two groups were decreased, and the levels in study group were lower than those in the control group (P < 0.05). There was no significant difference in the incidence of toxic and side effects between the two groups (P > 0.05). Conclusion: Paclitaxel combined with platinum NACT is markedly effective in the treatment of LACC. The regimen can reduce the blood loss, shorten the operation time, reduce the expression of Smac, Survivin and MMP-2 and inhibit tumor metastasis. It is conducive to the prognosis of the disease but attention should be paid to toxic and side effects.
2018 Vol. 24 (3): 385-389 [Abstract] ( 74 ) HTML (1 KB)  PDF (1345 KB)  ( 227 )
389 The Significance on the Patients with cN0 Papillary Thyroid Cancer for the First time Routine Prophylactic Central Lymph Node Dissection
WU Danping
DOI: 10.3969/j.issn.1006-6233.2018.03.010
Objective: To investigate cN0 papillary thyroid cancer patients for the first time in the treatment of routineprophylactic central lymph node dissection significance. Methods: From 2009 May to 2015 February in our hospital, 72 cases of patients with papillary thyroidcarcinoma were selected. All the patients were underwent routine prophylactic central lymph node dissection. The postoperative complications and prognosis were observed and the clinical pathological data and central lymph node metastasis were compared. Results: Postoperative pathology showed the central lymph node metastasis rate was 30.56%. tumor penetration thyroid membrane central lymph node metastasis rate was 53.33%, significantly higher than that of non penetrating 14.29%, the difference was statistically significant (P<0.05); Multiple tumors in patients with central lymph node metastasis rate was 70%,significantlyhigher than that of single tumor in 24.19% patients, the difference was statistically significant(P<0.05); The different age, gender, tumor diameter, tumor unilateral and bilateralpatientscentral lymph node metastasis rate showed no statistical significance (P > 0.05); Patients with postoperative complications in 3 cases, including 1 case of transient recurrent nerve injury, 2 cases of transient hypoparathyroidism. Patients were given aftertreatment, all symptomsinthe postoperative 2 ~ 6 months away. No deaths occurred during the follow-up period. Conclusion: cN0 papillary thyroid cancer for the first time in the treatment of routine prophylactic central lymph node dissection approach is necessary and safe.
2018 Vol. 24 (3): 389-393 [Abstract] ( 62 ) HTML (1 KB)  PDF (1347 KB)  ( 290 )
393 Effect of Atorvastatin and Betaloc on Serum Hcy hs-CRP and Serum Lipids in Patients with Coronary Heart Disease Combined with Transient Ischemia
ZHANG Furong, QI Ming, et al
DOI: 10.3969/j.issn.1006-6233.2018.03.011
Objective: To investigate the effects of atorvastatin and betaloc on serum Hcy, hs-CRP and blood lipid levels in patients with coronary heart disease complicated with transient ischemic attack. Methods: 80 patients with coronary heart disease complicated with transient ischemic attack admitted to our hospital from June 2015 to June 2017 were randomly divided into two groups, the control group received betaloc and the experimental group received atorvastatin. The electrocardiogram (ECG) improvement, the overall treatment effect of transient ischemic attack, disease-related parameters and adverse reactions were compared between the two groups. Results: The total effective rate of electrocardiogram improvement and the total effective rate of transient ischemic treatment in experimental group were significantly higher than those in control group (P <0.05); the thickness of intima-media, the maximum area of plaque transection, The levels of TG, TC, LDL-C, IL-8, HCY, Hs-CRP, NT-proBNP and FBG in the two groups were significantly lower than those in the control group (P <0.01). There was no significant difference (P> 0.05). Conclusion: Atorvastatin combined with betaloc has significant effect on serum Hcy, hs-CRP and serum lipid level in patients with coronary heart disease complicated with transient ischemia.
2018 Vol. 24 (3): 393-396 [Abstract] ( 227 ) HTML (1 KB)  PDF (1321 KB)  ( 203 )
396 Comparison of the Effects of Intravenous and Epidural Controlled Analgesia on the Postoperative Sedation Comfort and Adverse Reactions in Elderly Patients Undergoing Total Hip Arthroplasty
WEI Fengxiang, WANG Shoutian
DOI: 10.3969/j.issn.1006-6233.2018.03.012
Objective: To investigate and compare the effects of intravenous and epidural controlled analgesia on postoperative sedation, comfort and adverse reactions in elderly patients undergoing total hip arthroplasty. Methods: 120 elderly patients undergoing hip arthroplasty admitted from January 2016 to September 2017 were randomly divided into two groups: PCIA group received PCIA analgesia and PCEA group received PCEA analgesia. Pain, sedation, comfort, mental state and adverse reactions in both groups at rest and activity at different time points were compared between the two groupos. Results: The resting VAS scores of patients in PCEA group at 4h, 8h, 24h and 48h after operation were significantly lower than those in PCIA group. The VAS scores at 12h, 24h and 48h after operation were significantly lower than those in PCIA group. The scores of RSS at 4h, 8h, 12h, 24h and 48h were significantly lower than that of PCIA group, and BCS score was significantly higher than that of PCIA group. MMSE scores at 24h and 48h after operation were significantly higher than those in PCIA group. Nausea and vomiting (P <0.01). The incidence of lower extremity weakness and prolonged urinary catheter indwelling time was significantly higher than that of PCIA group (P <0.05), and there was a significant difference.Conclusion: Compared with PCIA, PCEA has better effect on postoperative pain, sedation, comfort and mental state in elderly patients undergoing hip replacement. However, attention should be paid to the side effects such as fatigue of the lower extremities and too long indwelling catheter.
2018 Vol. 24 (3): 396-400 [Abstract] ( 77 ) HTML (1 KB)  PDF (1338 KB)  ( 156 )
400 Effect of Sextant Minimally Invasive Percutaneous Pedicle Screw Internal Fixation in Treating Middle-aged and Elderly Spinal Fractures and Its Impact on Quality of Life
WANG Yuqiang, ZHAI Lei, SU Xuetao
DOI: 10.3969/j.issn.1006-6233.2018.03.013
Objective: To study the effect of Sextant minimally invasive percutaneous pedicle screw internal fixation in the treatment of middle-aged and elderly patients with spinal fractures and quality of life of patients, provide a reference for clinical treatment. Methods: 86 cases of elderly patients with thoracolumbar spine fractures treated in our hospital from March 2012 to March 2017 were selected as the subjects of this study. According to the simple random method, all patients were divided into control group (n = 41) and study group (n = 45). The patients in the control group were treated with open pedicle screw internal fixation, and the patients in the study group were treated with Sextant minimally invasive percutaneous pedicle screw internal fixation. The operation indexes, imaging indexes and quality of life of the two groups were compared between the two groups. Results: There was no significant difference in operative time between the two groups (P> 0.05). The bleeding volume and postoperative hospital stay in study group were lower than those in control group, with significant difference (P <0.05).The sagittal index of vertebral body and the height of the anterior vertebral body in the two groups were significantly higher than those in the control group, and the difference was statistically significant (P <0.05).The postoperative Cobb 's angle of the two groups were lower than preoperative, and the study group was lower than the control group, the difference was statistically significant (P <0.05); The postoperative study group had higher physical function, emotional function, somatic pain, social function and overall health score than the control group (P <0.05). Conclusion: Sextant minimally invasive percutaneous pedicle screw fixation for the treatment of middle-aged and elderly spine fracture effect is significant, can effectively reduce the body injury, improve the patient's kyphosis angle and vertebral height, promote patient recovery and improve patient quality of life, it is worth clinical Promotion.
2018 Vol. 24 (3): 400-404 [Abstract] ( 63 ) HTML (1 KB)  PDF (1345 KB)  ( 131 )
405 Efficacy and Safety of Nimodipine in Treatment of Cerebral Vasospasm Caused by Subarachnoid Hemorrhage
LIU Xiaojun, WU Kaiyi, LIU Nanwu, et al
DOI: 10.3969/j.issn.1006-6233.2018.03.014
Objective: To investigate the efficacy and safety of nimodipine in the treatment of cerebral vasospasm caused by subarachnoid hemorrhage. Methods: 108 patients with SAH admitted to our hospital from January 2015 to January 2017 were randomly divided into two groups. Patients in the control group were given routine treatment, nimodipine plus nimodipine, The GCS score, Hunt-Hess grade, GOS score, BI index, disease-related parameters and adverse reactions were compared between the two groups. Results: The scores of GCS in the nimodipine group were significantly higher than those in the control group after treatment, and the scores of Hunt-Hess in the nimodipine group were lower than those in the control group. The GOS scores in the 3-month group were significantly lower than those in the control group (P <0.05). After treatment, the left TCD, the right TCD, the amount of hematoma, the levels of IL-6, SBP and DBP in the two groups were significantly lower than those in the control group There was no significant difference between the two groups in the incidence of adverse drug reactions and the overall incidence of treatment (P> 0.05). Conclusion: Nimodipine is effective in treating cerebral vasospasm of subarachnoid hemorrhage and has high safety.
2018 Vol. 24 (3): 405-408 [Abstract] ( 67 ) HTML (1 KB)  PDF (1316 KB)  ( 179 )
408 Effects of Topiramate and Levetiracetam on Bone Metabolism in school-age Children with Epilepsy
LI Zhiyi
DOI: 10.3969/j.issn.1006-6233.2018.03.015
Objective: To investigate the effects of topiramate and levetiracetam on the bone metabolism in children with school-age epilepsy. Methods: A total of 82 cases of children with school-age epilepsy who were treated in our hospital from October 2014 to October 2017 were randomly divided into group A and group B, 41 cases in each group. The two groups of children were treated with topiramate and levetiracetam, respectively. The clinical efficacy and the effect on bone metabolism were compared between the two groups. Results: The total effective rate of clinical treatment in group A and group B was 87.80% (36/41) and 90.24% (37/41) respectively, with no significant difference between the two groups (χ2 = 0.12, P> 0.05) The incidence of adverse reactions in group B was 46.34% (19/41) and 19.51% (8/41) respectively after treatment. The difference between the two groups was statistically significant (χ2 = 6.68, P <0.05). After treatment, The levels of Ca, P, ALP, BAP and BMD in group A were (2.46 ± 0.09) mmoL / L, 1.47 ± 0.07 mmoL / L, 183.68 ± 26.54 U / L, 232.64 ± 17.02 and 2.24 ± 1.72, respectively. The indexes in group B were [(2.46 ± 0.08) mmoL / L], [(184.12 ± 24.83) U / L], [(233.52 ± 18.31)] and [(2.26 ± 1.86) ]Before and after treatment, there was no significant difference between each index (P> 0.05). Conclusion: Topiramate and levetiracetam have a good therapeutic effect on children with school-age epilepsy, but the incidence of adverse reactions is high and safety is low during the course of topiramate treatment. However, the short-term use of the two drugs on the bone metabolism No obvious effect.
2018 Vol. 24 (3): 408-411 [Abstract] ( 65 ) HTML (1 KB)  PDF (1328 KB)  ( 254 )
412 Effect of Laparoscopic Hysterectomy on Ovarian Function and Clinical Effect in Patients with Uterine Leiomyoma
LI Na
DOI: 10.3969/j.issn.1006-6233.2018.03.016
Objective: To explore the clinical effects of laparoscopic hysterectomy surgery on post-operative ovarian function. Methods: A total of 71 cases with uterine leiomyoma were chosen from November 2013 to September 2016, recceived either laparoscopic hysterectomy (observation group, n=34) or open hysterectomy (control group, n=37). The clinical effects, complication rate between two groups, and the reproductive hormone level were compared at 6 months after operation. Results: There were significant differences between observation group and control group in operative time, blood loss, postoperative exhaust, postoperative ambulation time and hospital stay (P<0.05). The incidence of complications was lower and postoperative life quality was better in observation group (P>0.05). Estradiol levels were lower than those before treatment in two groups, follicle stimulating hormone and luteinizing hormone levels were higher than those before treatment in two groups, The change range of the observation group was less than that of the control group. Conclusion: Laparoscopic hysterectomy has obvious clinical effect, Low complication rate and little influence on ovarian function, which is worthy of clinical promotion.
2018 Vol. 24 (3): 412-414 [Abstract] ( 66 ) HTML (1 KB)  PDF (1251 KB)  ( 100 )
415 Comparative Analysis of Small Saphenous Vein Thrombolysis by Infusion Catheter and Dorsalis Pedis Vein Directed Thrombolysis in Treatment for Central Venous Thrombosis after Temporary Inferior Vena Cava Filter
HUANG Yingjie, LING Yongzhi, et al
DOI: 10.3969/j.issn.1006-6233.2018.03.017
Objective: To investigate the therapeutic effect of temporary inferior vena cava in the treatment of thrombolytic and transposed thrombolysis in patients with acute iliofemoral vein thrombosis. Methods: From March 2012 to March 2016, 60 patients with acute iliac femoral vein thrombosis in our hospital were retrospectively analyzed. They were divided into catheter thrombolysis group (n=30) and dorsalis pedis thrombolysis group (n=30) according to the treatment. The clinical effects of the two treatment methods were compared after treatment, including the change of the circumference of the lower limbs, the rate of body swelling, the dosage of urokinase, the time of hospitalization, the rate of thrombolysis, the occurrence of thrombolysis, the long-term patency and the valvular function. Results: Catheter circumferential thrombolysis group before and after treatment, thigh and calf circumference difference and limb swelling rate were significantly higher than those in the dorsalis pedis thrombolysis group, the difference was statistically significant (P <0.05). The amount of urokinase and the time of hospitalization in the treatment of thrombolytic therapy were significantly lower than those in the back thrombolytic group (P <0.05). 2 weeks after treatment, the thrombolytic rate in the catheter thrombolysis group was significantly higher than that in the dorsalis pedis thrombolysis group, and the incidence of complications was significantly lower than that in the dorsalis pedis thrombolysis group. The above differences were statistically significant (P <0.05). Follow up for 18 months, venous catheterization rate in catheter thrombolysis group was significantly higher than that in the dorsalis pedis thrombolysis group, while the incidence of thrombotic syndrome (PTS) and thrombosis recurrence rate were significantly lower than those in the dorsalis pedis thrombolysis group, the difference was statistically significant (P <0.05). Conclusion: Thrombolytic therapy via small saphenous vein for patients with acute iliac femoral vein thrombosis has many advantages, such as good curative effect, short treatment time and low incidence of complications. It is worthy of further clinical application.
2018 Vol. 24 (3): 415-419 [Abstract] ( 69 ) HTML (1 KB)  PDF (1338 KB)  ( 112 )
419 Therapeutic Effect of Exercise Therapy on Chronic Left Ventricular Ejection in Elderly Patients with Heart Failure
ZHOU Maosong, SUN Xiaomei, LI Li
DOI: 10.3969/j.issn.1006-6233.2018.03.018
Objective: To evaluate the efficacy of exercise therapy in elderly patients with chronic heart failure with preserved left ventricular ejection fraction (HF-PEF). Methods: 130 elderly patients with chronic HF-PEF were divided into the observation group and the control group. The two groups were all received conventional medical treatment, but the observation group was given exercise therapy additionally. Before treatment and 8 weeks after treatment, the 6 minute walking distance, cardiac function level, left ventricular ejection fraction, plasma N terminal B type natriuretic peptide precursor (NT-proBNP) and quality of life score were collected and analyzed in two groups. After 24 weeks of follow-up, the readmission rate and fatality rate were compared between the two groups. Results: After treatment, all the indexes of the two groups were improved (P<0.05), and all indexes in the observation group (except left ventricular ejection fraction) were significantly better than those in the control group (P<0.05). The rate of readmission in the observation group was significantly lower than that of the control group (P<0.05). Conclusions: Exercise therapy based on routine drug therapy can significantly improve cardiac function, exercise endurance and quality of life in elderly patients with chronic HF-PEF.
2018 Vol. 24 (3): 419-422 [Abstract] ( 79 ) HTML (1 KB)  PDF (1330 KB)  ( 152 )
422 Clinical Analysis of Low Molecular Weight Heparin and Aspirin in Treating Recurrent pregnancy loss Caused by Antiphospholipid Antibodies
ZHANG Shuyun, ZHANG Hong, WANG Yunjie, et al
DOI: 10.3969/j.issn.1006-6233.2018.03.019
Objective: To investigate the clinical efficacy of low molecular weight heparin combined with aspirin in the treatment of recurrent spontaneous abortion caused by antiphospholipidantibodies. Methods: 88 patients with recurrent spontaneous abortion caused by anti-phospholipid antibody were selected from December 2015 to December 2017 in our hospital. Patients were divided into control group (n = 44) and observation group (n = 44) The patients in the control group and observation group were treated with aspirin and low molecular weight heparin together with aspirin, respectively. The clinical effects of the two groups were compared. Results: After treatment, the total effective rate in the observation group and the control group after treatment was 88.64% and 65.91%, respectively. The difference between the two groups was statistically significant (χ= 6.47, P <0.05). The observation group and the control group were pregnant There was no significant difference in the incidence of complications among the two groups (P> 0.05). After treatment, E2 and P levels in both groups were significantly improved, but the improvement in observation group was significantly better than that in control group (P <0.05). After treatment, the levels of IFN-γ, IL-4 and IFN-γ / IL-4 in the observation group were significantly better than those in the control group (P <0.05). Conclusion: Low molecular weight heparin combined with aspirin in patients with recurrent spontaneous abortion caused by antiphospholipid antibodies has a significant clinical effect, which is helpful for the expression of the hormone and the enhancement of immunity in patients, and also helps to improve the pregnancy outcome of patients with high safety. It is worth clinical promotion.
2018 Vol. 24 (3): 422-426 [Abstract] ( 90 ) HTML (1 KB)  PDF (1349 KB)  ( 154 )
426 The Effect of Propofol combined with Midazolam in the treatment of the Elderly Patients with Unilateral Lower Limb Surgery
YU Fanting
DOI: 10.3969/j.issn.1006-6233.2018.03.020
Objective: To explore the elderly patients with unilateral lower extremity surgery propofol anesthesia, propofol combined with midazolam anesthesia sedation anesthesia effect. Methods: From July 2015 to July 2017 in our hospital, 86 cases of elderly patients with unilateral lower extremity surgery as the research object. Patients were randomly divided into two groups according to a simple randomized grouping method, the control group (n=43) treated with propofol anesthesia, study group (n=43) treated with propofol combined with midazolam anesthesia. Observe two groups before anesthesia (T0) the effective time of anesthesia, intraoperative (T1), 1.5h (T2), end of operation (T3) each time the heart rate (HR), mean arterial pressure (MAP) level; the standard for evaluation of sedation (Ramsay score) were assessed before sedation, induction period, The degree of sedation during the operation and after operation was compared; the sedative onset time, awake time, response time and the rate of adverse reactions were compared between the two groups. Result: The patients of two groups with HR, MAP levels among different groups at different time points and measurements of time difference (P<0.05). The research group T1 HR, T0 and MAP levels were significantly lower than the control group P<0.05); T0, T2, T3 HR, no significant level of MAP the difference (P>0.05). After sedation (intraoperative, postoperative) study group Ramsay sedation score was significantly better than the control group, the difference was statistically significant (P<0.05). The study group sedation onset Time, waking time and response time were significantly shorter than those in the control group (P<0.05). There was no significant difference in the rate of adverse drug reactions between groups(χ2=1.400,P>0.05). Conclusion: Two schemes on elderly patients with unilateral lower extremity surgery has higher safety, but propofol combined with midazolam sedation effect is more ideal, the calm effect is fast, deep level of sedation, postoperative anesthesia in awake patients, low rate of adverse reactions, so it has the value of clinical application.
2018 Vol. 24 (3): 426-430 [Abstract] ( 54 ) HTML (1 KB)  PDF (1347 KB)  ( 109 )
430 Analysis of the Changes of Plasma Brain Natriuretic Peptide in children with Kawasaki Disease and its Correlation with Heart Function
SHI Zhengying, GUAN Jianhong, et al
DOI: 10.3969/j.issn.1006-6233.2018.03.021
Objective: To investigate the changes of plasma brain natriuretic peptide in children with Kawasaki disease and its correlation with cardiac function. Methods: From July 2015 to July 2017 in our hospital, 39 cases of pediatric children with Kawasaki disease as the observation group, according to the disease is divided into 20 cases of acute children, 19 cases of convalescent patients; the same period in our hospital 50 cases of healthy children as a control group. The levels of plasma brain natriuretic peptide were detected in the two groups. Meanwhile, the cardiac function indexes in the observation group were also examined. The correlation between plasma brain natriuretic peptide and cardiac function was analyzed. Results: The levels of plasma brain natriuretic peptide in acute stage were significantly higher than those in recovery stage and control group (P <0.05). The level of plasma natriuretic peptide in convalescent group was higher than that in control group, the difference was statistically significant (P <0.05).The indexes of LVSF, CI, LVEF in acute stage were significantly lower than those in recovery stage, the difference was statistically significant (P <0.05). The difference of E / A index and recovery period There was no significant difference between the two groups (P> 0.05). Sodium levels of plasma brain natriuretic peptide and children with acute LVSF, CI, LVEF indicators show a significant negative correlation (P <0.05), and E/A showed no significant correlation (P> 0.05). Conclusion: The level of plasma brain natriuretic peptide in children with acute Kawasaki disease is significantly increased, which is negatively correlated with LVSF, CI and LVEF, which is of great importance for early clinical diagnosis in children.
2018 Vol. 24 (3): 430-433 [Abstract] ( 61 ) HTML (1 KB)  PDF (1332 KB)  ( 214 )
433 Risk Factors and Preventive Measures of Catheter Related Blood Stream Infection
RAN Fang, LI Xiaodong, ZHAO Chunyan, et al
DOI: 10.3969/j.issn.1006-6233.2018.03.022
Objective: To explore the risk factors and preventive measures of dialysis catheter related blood stream infection (CRBSI). Methods: 63 CRBSI patients who had received central venous indwelling catheter for treatment in the Nephrology of our hospital from February 2013 to March 2017 were selected as the CRBSI group, and another 63 cases without infection given central venous indwelling catheter as control group. The related risk factors and pathogenic characteristics of CRBSI were analyzed. Results: The occurrence of CRBSI was related with catheterization outside of the hospital, internal jugular vein catheterization, length of hospital stay in ICU, body mass index (BMI), mean artery pressure (MAP), acute physiology and chronic health evaluation (APACHE) Ⅱscores, catheter dwelling time, and CD4+, with statistically significant difference between the two groups (P<0.05). Femoral vein catheterization, the use of immunosuppressor, plasma catheterization or double plasma filtration, the increase of fasting plasma glucose, albumin and immunoglobulin G (IgG) levels were not related with the occurrence of CRBSI, with statistically significant difference (P>0.05); the multiple-factor analysis showed that: Catheterization outside of the hospital, internal jugular vein catheterization, MAP, APACHE) Ⅱscore, catheter dwelling time, and CD4+ were important risk factors of the occurrence of CRBSI (P<0.05). The length of hospital stay in ICU and BMI showed no definite correlation (P>0.05); the gram positive bacteria was the major microorganism detected, which accounted for 50.78%, followed by gram negative bacteria, which accounted for 36.51%; the common pathogenic bacteria were staphylococcus epidermidis, staphylococcus aureus and enterobacter cloacae. Conclusion: MAP, APACHE) Ⅱscore, catheter dwelling time, and CD4+ were important risk factors of the occurrence of CRBSI, gram positive cocci is the main pathogen for CRBSI; therefore, in clinical practice, susceptibility testing should be performed according to the pathogen, and antibacterial agents should be selected according to antimicrobial susceptibility results; aseptic operation should be strictly implemented, and catheterization time shortened to strengthen the prevention for critical illness and immune hypofunction and reduce the incidence rate of CRBSI.
2018 Vol. 24 (3): 433-437 [Abstract] ( 77 ) HTML (1 KB)  PDF (1339 KB)  ( 253 )
437 Effect of Functional Endoscopic Sinus Surgery on Chronic Nasosinusitis with Nasal Polyps
SHI Jianfei, LI Jia
DOI: 10.3969/j.issn.1006-6233.2018.03.023
Objective: To evaluate the efficacy of functional endoscopic sinus surgery for chronic sinusitis with nasal polyps by observing the NRS score, postoperative complications and prognosis of patients. Methods: 124 cases of patients with chronic sinusitis complicated with nasal polyps treated in our hospital were selected as the study objects, and were divided into observation group and control group, according to random number table method, 62 cases in each group. The control group were given routine surgery treatment, and the observation group were given functional endoscopic sinus surgery. Clinical indicators, pain degree, endoscopic findings, quality of life, clinical efficacy and olfactory function were observed, and complications and recurrence rates were figured in the two groups. Results: Operation time, nasal ventilation time, hospitalization time, intraoperative blood loss and mucosal recovery time in the observation group were significantly lower than those in the control group (P < 0.05). At 6 months after operation, NRS, Lund-Kennedy and SNOT-20 scores were significantly lower than those before operation in the two groups (P < 0.05), and those in the observation group were lower than those in the control group (P < 0.05). Total effective rate of the observation group was 96.77%, significantly higher than that of 87.10% of the control group (P < 0.05). At 3 months after operation, the score of olfactory function was significantly lower than that before operation in the two groups (P < 0.05). and that in the observation group was lower than that in the control group (P < 0.05). Complication rate of the observation group was 3.23%, and the recurrence rate was 4.84%, which were lower than that of 14.52% and 16.13% in the control group (P < 0.05). Conclusion: Compared with conventional surgery, functional endoscopic sinus surgery can not only reduce the pain of patients with chronic sinusitis and nasal polyps, but also improve the clinical curative effect and reduce the complication and recurrence rate.
2018 Vol. 24 (3): 437-441 [Abstract] ( 58 ) HTML (1 KB)  PDF (1337 KB)  ( 113 )
452 Clinical Study of Endoscopic Surgery combined with Laparoscopic Lavage in the treatment of Severe Acute Pancreatitis
LI Huazhi, ZHU Run
DOI: 10.3969/j.issn.1006-6233.2018.03.027
Objective: To study the clinical efficacy of endoscopic surgery combined with laparoscopic lavage in the treatment of severe acute pancreatitis. Methods: 154 patients were randomly divided into observation group and control group. The control group was treated with routine comprehensive therapy + endoscopic retrograde cholangio-pancreatography. On the basis of this, the observation group was given laparoscopic lavage treatment. The efficacy, symptoms, signs, biochemical indicators and postoperative complications were observed in the two groups. Results: There was no significant difference in the curative effect between the two groups. However, the recovery time of abdominal symptoms, body temperature, amylase and the time of anal exhaust were faster than those in the control group. The levels of TNF-α, IL- IL-8 were significantly improved, the incidence of complications in the observation group was lower than that in the control group (P <0.05 or 0.01). Conclusion: Endoscopic combined with intraperitoneal lavage is effective in the treatment of severe acute pancreatitis, which can reduce the duration of clinical symptoms and improve the clinical blood biochemical indexes and reduce the incidence of surgical complications.
2018 Vol. 24 (3): 452-455 [Abstract] ( 66 ) HTML (1 KB)  PDF (1317 KB)  ( 112 )
455 The Application of Desogestrel and Ethinylestradiol Tablets in the treatment of Abnormal Uterine Bleeding in Perimenopause
SUN Xingxing, et al
DOI: 10.3969/j.issn.1006-6233.2018.03.028
Objective: To investigate the abnormal uterine bleeding in perimenopausal patients, using the clinical effect of marvelon. Methods: 84 cases of abnormal uterine bleeding in the perimenopausal period were selected and divided into two groups randomly, 42 cases in each group. Mifepristone (1 times /d, 12.5mg each time) was used as the control group, and Desogestrel and Ethinylestradiol Tablets (2-3 /d, 3-4 tablets each time, 1 /d) was used as the observation group. The levels of sex hormones (follicle stimulating hormone (FSH), progesterone (P), estradiol (E2), luteinizing hormone (LH)), uterine volume and endometrial thickness, adverse reactions and therapeutic effects in two groups after 3 courses of treatment were observed. Results: The levels of FSH, P, E2 and LH in the observation group were significantly lower than those in the control group (P<0.05). The measurements of uterine volume and endometrium thickness in the observation group were less than those of the control group (P<0.05). The total effective rate of clinical treatment in the control group was 80.95%, and the total effective rate in the observation group was 92.86% (P<0.05). The adverse incidence rate of the control group was 7.14%, and the adverse incidence rate of the observation group was 19.05% (P<0.05). Conclusion: Compared with mifepristone in the treatment of abnormal uterine bleeding in perimenopausal period, Desogestrel and Ethinylestradiol Tablets has a more significant clinical effect, and improves the indicators and uterus of patients more obviously, but it is easy to cause acne and obesity, so we should pay attention to drug reactions.
2018 Vol. 24 (3): 455-459 [Abstract] ( 58 ) HTML (1 KB)  PDF (1337 KB)  ( 190 )
459 Effect of Open Reduction and Internal Fixation in the Treatment of Sanders Type IV Calcaneal Fracture
DU Guojun, LIU Yi
DOI: 10.3969/j.issn.1006-6233.2018.03.029
Objective: To investigate the influence of open reduction and internal fixation on Sanders type calcaneal fracture and the grading of Maryland foot. Methods: 80 patients with Sanders type IV calcaneal from January 2016 -2016 year in December in our hospital were fracture, were randomly divided into two groups, the control group using poking reduction and internal fixation, the study group were treated with open reduction and internal fixation, compared two groups of patients the results and the effect on the Maryland foot score. Results: Before treatment, there was no significant difference in the Gissane angle and Bohler angle between the two groups (P>0.05), which was improved after treatment, and the study group was significantly better than the control group (P<0.05). Before treatment, there was no significant difference in the width of root bone and the height of root bone between the two groups (P>0.05), which was improved after treatment, and the study group was significantly better than the control group (P<0.05). In the comparison of the Maryland foot score of the two groups of patients, the good rate of Maryland score in the study group was significantly higher than that of the control group (P<0.05). Conclusion: Open reduction and internal fixation for Sanders type IV calcaneal fractures are helpful to improve Gissane angle, Bohler angle, root width and root height. Meanwhile, the Maryland foot score is higher.
2018 Vol. 24 (3): 459-463 [Abstract] ( 53 ) HTML (1 KB)  PDF (1347 KB)  ( 160 )
463 Clinical Analysis of Double Chamber Pacemaker in the treatment of Senile Patients with Chronic Cardiac Arrhythmia
MA Yuanfeng
DOI: 10.3969/j.issn.1006-6233.2018.03.030
Objective: To investigate the clinical effect of double chamber pacemaker in the treatment of senile patients with chronic cardiac arrhythmia. Methods: 100 elderly bradycardia patients admitted to our hospital from January 2014 to November 2017 were randomly divided into two groups. Patients in DDD group were treated with double-chamber pacemaker while those in VVI group were treated with single-chamber cardiac pacing The disease-related parameters, NYHA classification, quality of life and follow-up results were compared between the two groups. Results: The levels of LVEF, SV, CO and CI in DDD group were significantly higher than those in VVI group after treatment. The LVEDD, PAV, BV, PV, CK-MB and cTnⅠ in patients with DDD were significantly lower than those in VVI group The scores of quality of life in each dimension of SF-36 in each month were significantly higher than those in VVI group (P <0.01), and the NYHAⅠ ~ Ⅱlevel of patients in treatment group were significantly higher than those in VVI group The incidence of atrial fibrillation and hospitalization due to heart failure were significantly lower than that of VVI group, with significant difference (P <0.05). Conclusion: The double-chamber cardiac pacemaker treatment of elderly patients with chronic cardiac arrhythmia significant clinical effect, can significantly improve the prognosis, with reference.
2018 Vol. 24 (3): 463-466 [Abstract] ( 59 ) HTML (1 KB)  PDF (1314 KB)  ( 147 )
466 Application of WeChat Software in Functional Recovery of Elderly Postoperative Patients with Intertrochanteric Fracture
ZHOU Weina, LI Ning, WANG Yanming, et al
DOI: 10.3969/j.issn.1006-6233.2018.03.031
Objective: To investigate the application effect of WeChat software management in patients with fracture of femoral intertrochanteric function after restoration. Methods: 100 elderly patients with femur from December 2013 to December 2016 were fracture, were randomly divided into two groups, all patients were with bone plied intertrochanteric fracture diagnosis, surgery with PFNA internal fixation in the hospital. Two groups were given routine nursing in Department of orthopedics, the same rehabilitation training. 50 cases in the control group were given regular discharge guidance after discharge, and regular telephone follow-up was carried out. On the basis of the experimental group, an irregular WeChat return visit was conducted. The recovery of hip joint, self-care ability and nursing satisfaction were compared between the two groups. Results: After three months of discharge, the Harris score, the ADL scale and the nursing satisfaction were higher in the experimental group than in the control group, and the difference was statistically significant (P < 0.05). Conclusion: The application of WeChat software can promote the recovery of hip function and the improvement of self-care ability and improve the satisfaction of nursing in the elderly.
2018 Vol. 24 (3): 466-469 [Abstract] ( 65 ) HTML (1 KB)  PDF (1319 KB)  ( 119 )
469 Clinical Observation of Radioactive 125I Particles in the treatment of Pancreatic Cancer Patients
LIU Xianxing, LIANG Jingbo, CHANG Fan, et al
DOI: 10.3969/j.issn.1006-6233.2018.03.032
Objective: To investigate the effect of radioactive 125I particles in pancreatic cancer patients. Methods: 58 pancreatic cancer patients admitted n our hospital were selected and divided into the control group and the experiment group by order of medical treatment. The control group were treated by palliative operation and the experiment group were treated by CT guided radioactive 125I particles implantation. Two groups were both treated by conventional anti-inflammatory, analgesic, fluid replacement and other supporting symptomatic treatment after operation. The CEA, CA125, CA199, pain assessment, quality of life score, solid tumor curative effect and median survival time were compared before treatment and 1 month after treatment. Results: Compared with before treatment, the CEA, CA125 and CA199 level were lower (P<0.05), the experiment group were more obviously (P<0.05).Compared with before treatment, the VAS score were lower (P<0.05), the experiment group were more obviously (P<0.05) . Compared with the control group after treatment the tumor curative effect were better (P<0.05), the median survival time were longer(P<0.05) . Conclusion: Radioactive 125I particles can significantly reduce serum CEA, CA125 and CA199 levels in patients with pancreatic cancer, effectively alleviate the pain, improve clinical symptoms, improve the quality of life of patients, the tumor tissue has good killing effect, can effectively prolong the relative survival time of patients.
2018 Vol. 24 (3): 469-473 [Abstract] ( 76 ) HTML (1 KB)  PDF (1342 KB)  ( 168 )
482 Effect of Different Concentrations of Contrast Agent on the Quality of Lower Extremity Vein Image Got by Direct-scan Multi-slice Spiral CT
WANG Ning, LI GaoYang, ZHANG Dan, et al
DOI: 10.3969/j.issn.1006-6233.2018.03.036
Objective: To investigate the effect of different concentration contrast agents on the image quality of the lower extremity venography with multi-slice spiral CT. Methods: The patients received direct method lower extremity venous examination were collected from 2014 to 2016 in our hospital. The injection rate of contrast medium was 3ml / s, the delay time was 50s and the scanning time was 20s.The images were divided into groups according to the different concentrations, and the original image data were acquired. The original image data were acquired and analyzed by image reconstruction. The images were evaluated and analyzed statistically. Results: In this group of 40 patients, 80 sides of the lower extremity deep vein, the scores of each group were as follows: the concentration of 1: 4 group, 1 points for 13.04%, 2 points for 52.17%, 3 points for 34.79%;concentration of 1: 6 group, 1 points for the 11.11%, 2 points for 22.22%, 3 points for the 66.67%;the concentration of 1: 7 group, 1 point for 18.18%, 2 points for 18.18%, 3 points for 63.64%;the concentration of 1: 9 group, 1 points for the 0,2 points for 24%, 3 points for 76% cases. Conclusion: This study demonstrates the use of contrast media at a contrast agent concentration of 1: 6, 1: 7, 1: 9 can get a clear image of blood vessels. But the concentration of contrast agent set 1: 9 not only can provide the best clinical image data, but also reduce the amount of contrast agent, can be considered the best venous CTV of the lower extremity concentration.
2018 Vol. 24 (3): 482-485 [Abstract] ( 65 ) HTML (1 KB)  PDF (1785 KB)  ( 231 )
485 Comparative Analysis of Breast Fibroadenoma and Phyllodes Tumor Ultrasound Manifestations
CUI Yan
DOI: 10.3969/j.issn.1006-6233.2018.03.037
Objective: To explore the ultrasonographic features and characteristics of breast fibroadenoma and lobular tumor, to provide guidance for the imaging diagnosis of breast lesions. Methods: Pathologically proved breast fibroadenoma (n=86 cases), phyllodes tumor (21 cases) of patients with clinical data, 2-D ultrasound and color Doppler flow information were collected. The differences and similarities of ultrasonic manifestations of two kinds of breast lesions were compared and analyzed statistically. Results: The maximum diameter of the breast fibroadenoma was (20.14 + 8.71) mm. The boundary of the lesion was clear and the shape was more regular in the oval shape and the Doppler spectrum was a low resistance type. The blood flow signal 0~ grade I was 68.6%. The internal echo was most homogeneous, the internal echo of the lesion was slightly hypoechoic to equal echo, a few echoes in the rear were enhanced, the calcification in the tumor was rare, and the cystic degeneration was not detected. Phyllodes tumor of the largest tumor diameter was (32.59 + 10.49) mm. The boundary was clear, lobulated edge and many of the internal echo unevenly, visible high echo separation. The blood flow signal II ~ III grade accounted for 61.9%. There were fewer cystic changes and calcification in the lesion. Compared with phyllodes tumor of breast fibroadenoma, the maximum diameter of the lesions, the average detection rate and tumor cystic degeneration were lobulated were significantly reduced (P<0.05), internal echo and blood flow signal less uniform examination rate (0~ grade) was increased (P<0.05). There was no statistically significant difference in the aspect ratio, axillary lymph node change, calcification detection rate, Vmax and RI index between the two groups (P>0.05). Conclusion: Color Doppler ultrasound is part of a specific index in the prediction of breast fibroadenoma and phyllodes tumors, but the ultrasound findings of two there is also a certain coincidence, clinical qualitative judgment, must pay attention from more angles.
2018 Vol. 24 (3): 485-489 [Abstract] ( 62 ) HTML (1 KB)  PDF (1341 KB)  ( 235 )
489 Ultrasonic Diagnosis of Discoid Meniscus of Knee Joint in Children
WANG Yu, GENG Hua, HE Man, et al
DOI: 10.3969/j.issn.1006-6233.2018.03.038
Objective: To study the diagnostic value of ultrasonography in the discoid meniscus of the knee joint in children. Methods: 28 patients diagnoed as discoid menisci by MRI were examined by ultrasonography, the width and thickness of menisci were measured. Results: The ultrasonography results of 28 patients were abnormol.The the width and thickness of menisci measured between Ultrasonography and MRI were significantly different (P＜0.05). Both of them were not consistent (Kappa＜0.4). Conclusions: Ultrasonography can make relatively accurate diagnosis for discoid menisci in children,and can be an effective mean to detect discoid menisci.
2018 Vol. 24 (3): 489-492 [Abstract] ( 131 ) HTML (1 KB)  PDF (2433 KB)  ( 147 )
492 Effect of Guizhi Fuling Pill Combined with Albendazole on Serum VEGF and Flk-1 and Inflammatory Factors Levels of Patients with Endometriosis
LEI Xia, WANG Yuan, SHI Xiaoyan, et al
DOI: 10.3969/j.issn.1006-6233.2018.03.039
Objective: To explore the clinical efficacy of Guizhi fuling capsules combined with albendazole in the treatment of endometriosis (EMT) and effects on the serum levels of vascular endothelial growth factor (VEGF), fetal liver kinase (Flk-1) and inflammatory factors. Methods: 116 patients with EMT admitted in our hospital from February 2015 to December 2016 were selected and randomly divided into two groups. The patients in control group were treated with pantoprazole while the patients in the observation group were treated with Guizhi Fuling pill and albendazole. The clinical efficacy, the levels of serum VEGF, Flk-1, inflammatory factors before and after treatment and incidence of adverse reactions were compared between two groups. Results: After treatment, the total effective rate of observation group was 93.1%, which was significantly higher than that of the control group (P<0.05). Compared with before treatment, the levels of serum VEGF, Flk-1 IL-6, IL-8 and CRP of two groups after treatment were significantly lower than before (P<0.01), and the observation group were lower than those of the control group (P<0.01). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Guizhi Fuling pill combined with albendazole can effectively enhance the clinical efficacy with high safety in the treatment of EMT. It may be related to the decrease of serum VEGF, Flk-1 and inflammatory factors levels.
2018 Vol. 24 (3): 492-495 [Abstract] ( 80 ) HTML (1 KB)  PDF (1323 KB)  ( 140 )
499 Clinical Observation on treatment of Chronic Urticaria with Integrated Traditional Chinese and Western Medicine
TIAN Zhilan, ZHANG Liangqi, HOU Junrong
DOI: 10.3969/j.issn.1006-6233.2018.03.041
Objective: To explore the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of chronic urticaria. Method: 72 patients with chronic urticaria were randomly divided into two groups, 36 cases in the control group were given western medical treatment; the 36 cases in control group were treated on the basis of Western medicine plus Angelica nourishing blood, dispelling wind and relieving itching, both groups last 4 weeks for a course of treatment. Result: At the end of the 4-week course, the total effective rates of the treatment group and the control group were 91.67% and 72.22%. After 4 weeks of drug withdrawal, the recurrence rate of the treatment group and the control group were 12.12% and 38.46% respectively. The difference between the total effective rate and the recurrence rate of the two groups was statistically significant (P<0.05). Conclusion: The combination of traditional Chinese and Western medicine has a high curative effect on the treatment of chronic urticarial, the recurrence rate is low and the adverse reaction is less.
2018 Vol. 24 (3): 499-502 [Abstract] ( 61 ) HTML (1 KB)  PDF (1325 KB)  ( 262 )
502 Expression and Significance of Integrin α2β1 Protein and CD44V3 Protein in Cervical Squamous cell Carcinoma
ZHAO Yaohong, QI Zhiyu, GUO Dongxia, et al
DOI: 10.3969/j.issn.1006-6233.2018.03.042
Objective: To investigate the expression and clinical significance of integrin α2β1 protein and CD44V3 protein in cervical squamous cell carcinoma. Methods: Expression protein of integrinα2β1 and CD44V3 were detected in 80 cases of cervicals quamous cell carcinoma and normal cervical tissues 50 cases by SP method of immunohistochemistry. The correlation between the expression of two indexes in cervical squamous cell carcinoma and the relationship with the biological behavior of cervical squamous cell carcinoma were investigated. Result: The positive expression rates of integrin alpha 2 beta 1 protein and CD44V3 protein in cervical squamous cell carcinoma were 73.4% and 71.3%, respectively, which were all higher than those in normal cervical mucosa tissues, and the difference was statistically significant (P < 0.05). Integrin alpha 2 beta 1 protein and CD44V3 protein were significantly related to the degree of differentiation, clinical stage, lymph node metastasis and depth of invasion of cervical squamous cell carcinoma. The expression of integrin alpha 2 beta 1 protein and CD44V3 protein in the squamous cell carcinoma of the cervix was positively correlated (R =0.67). Conclusion: Expression of integrinα2β1 and CD44V3 protein may play an important role in the occurrence and development of cervical squamous cell carcinoma. They have positive synergy, and be used as a judgment of local invasion, distant metastasis and prognosis prediction factors of cervical squamous cell carcinoma.
2018 Vol. 24 (3): 502-506 [Abstract] ( 48 ) HTML (1 KB)  PDF (1714 KB)  ( 131 )
506 Study on the Influencing Factors of Urban Residents' Health Behavior in Chengde
FU Zhinan, HUANG Zhigang, HAN Huiqiang, et al
DOI: 10.3969/j.issn.1006-6233.2018.03.043
Objective: To find out the status of the distribution of health behavior factors in urban residents in Chengde, to guide the residents to develop good health behavior and avoid bad behavior. Methods: A multi stage stratified random sampling method was used to investigate the households of 15 years old and above in 5 counties of Chengde. Results: There were 1,320 men, 687 men (52.05 percent) and 633 women (47.95 percent).Men's smoking rate was 27.5%, women's smoking rate was 2.8%, men's drinking rate was 76.9%, and women's drinking rate was 23.5%.53.7 percent of people took part in physical activity within six months.88.9% of the people brush their teeth twice a day on average; 80.1 percent had at least one health check in nearly 1 year;There was a statistically significant difference in the self-assessment of the health status of the population with different physical exercise and brushing condition (P < 0.01). Conclusion: The male urban residents in Chengde have a high frequency of smoking, especially the high drinking amount. They take part in physical exercise, brush their teeth and have a higher awareness of health examination. Individualized health promotion strategies should be formulated according to the different characteristics of the population so that residents can develop good living habits and healthy behavior patterns.
2018 Vol. 24 (3): 506-510 [Abstract] ( 71 ) HTML (1 KB)  PDF (1335 KB)  ( 163 )
510 Effect of Health Education with Cognitive Intervention on Nursing Effect After PTBD Operation in Department of Hepatobiliary Surgery
DING Xinran
DOI: 10.3969/j.issn.1006-6233.2018.03.044
Objective: To analyze the effect of health education of cognitive intervention on the postoperative nursing effects of percutaneous transhepatic biliary drainage (PTBD) in Department of Hepatobiliary Surgery. Methods: 86 cases in our hospital from department of hepatobiliary surgery for the treatment of PTBD were selected as the research objects, and randomly divided into the control group receiving routine health education, cognitive group giving comprehensive and standard cognitive intervention on the basis of the control group of health education, with 43 cases in each group. The postoperative nursing effect and complications were compared between the two groups. Results: The related knowledge about disease and PTBD in the cognitive group were significantly higher than those in the control group, and patients with stable state of mind, and actively cooperate with the treatment was significantly higher than those in the control group, and patients with acceptable time for more than 3 months was significantly higher than that of control group (P<0.01). The incidence rates of infection and catheter removal in the cognitive group were significantly lower than those in the control group (P<0.05). Conclusion: Cognitive intervention of health education in the department of hepatobiliary surgery for PTBD can significantly improve the cognitive level of disease, promote actively cooperate with the treatment, with psychological adjustment, which can significantly improve the nursing effects after surgery and reduce the incidence rate of postoperative infection and extubation, so it is worthy of clinical promotion.
2018 Vol. 24 (3): 510-513 [Abstract] ( 65 ) HTML (1 KB)  PDF (1321 KB)  ( 158 )
514 Effect of Rapid Rehabilitation Nursing on Postoperative Pain and Rehabilitation in Patients Undergoing Hysteroscopic Uterine Surgery
DU Haixia, SU Fenglong, ZHAO Qiaomian
DOI: 10.3969/j.issn.1006-6233.2018.03.045
Objective: To investigate the effect of rapid rehabilitation nursing on postoperative pain and rehabilitation in patients taken hysteroscopic hysterectomy. Methods: 90 cases of hysteroscopic hysterectomy patients in our department from August to December 2016 were randomly divided into the observation group and the control groupaccording to the proportion of 1:1, each with 45 cases. The patients in the control group were received routine care during the perioperative period, and the observation group was received rapid rehabilitation nursing during the perioperative period. The operation stress, postoperative pain and rehabilitation of the two groups were compared. Results: Cortisol and epinephrine after 1d of the operation in the observation group was lower than that in the control group, and the postoperative pain score after 24h of the operation was lower than that in the control group, the difference was statistically significant (P<0.05). The anal exhaust time, ambulation time, defecation time and length of stay in the observation group were shorter than those in the control group, and the complication was less than that in the control group, the difference was statistically significant (P<0.05). Conclusion: Rapid rehabilitation nursing can reduce the postoperative pain of patients undergoing hysteroscopic hysterectomy, accelerate the postoperative rehabilitation and shorten the hospitalization time.
2018 Vol. 24 (3): 514-517 [Abstract] ( 61 ) HTML (1 KB)  PDF (1319 KB)  ( 146 )
517 Detection and Clinical Significance of Serum Inflammatory Factors and Biochemical Indexes in patients with Vascular Dementia
ZHANG Zuonian, et al
DOI: 10.3969/j.issn.1006-6233.2018.03.046
Objective: To explore the clinical significance of detecting serum inflammatory factors and biochemical indexes in patients with vascular dementia (VD) so as to provide reference for the clinical diagnosis of patients with this disease. Methods: 82 patients with vascular dementia (observation group) admitted to our hospital from October 2012 to October 2016 and 85 normal persons (control group) who underwent health examination in our hospital during the same period were enrolled in this study. Serum levels of inflammatory cytokines and life indicators, analysis of the two groups were included in the indicators of the differences between the levels. Results: The levels of IL-1β, TNF-α and IL-6 in the observation group were [(62.69 ± 31.08) pg / mL], [(8.41 ± 2.06) foml / mL] and [(10.97 ± 5.12) pg / mL] were significantly higher in the control group than those in the control group (P <0.05) The levels of Hcy, HDL-C, LDL-C, triglyceride and apolipoprotein A were [(37.51 ± 19.34) umoL / L, 0.90 ± 0.23 nmoL / L, 3.14 ± 1.11 nmoL / L, 1.74 ± 1.02 mmoL / L, / L], there was significant difference between each index level and the control group (P <0.05). There was no significant difference in the levels of other inflammatory factors and biochemical indexes between the two groups (P> 0.05). Conclusion: There are differences in inflammatory factors and biochemical indicators between vascular dementia patients and normal persons. Joint detection of inflammatory factors and biochemical indicators is helpful for clinical diagnosis of vascular dementia patients.
2018 Vol. 24 (3): 517-520 [Abstract] ( 69 ) HTML (1 KB)  PDF (1325 KB)  ( 201 )
520 Correlation and Influencing Factors of Biochemical iIndex and Psychological Function in Maintenance Hemodialysis Patients
HE Jun
DOI: 10.3969/j.issn.1006-6233.2018.03.047
Objective: To explore the correlation of biochemical indexes and psychological function in maintenance hemodialysis patients, and to analyze the influencing factors. Methods: 58 patients undergoing maintenance hemodialysis (study group) in our hospital during the period from November 2015 to December 2016 and 30 healthy volunteers (healthy group) who received physical examination in our hospital during the same period were selected as the subjects. Patients in the study group were divided into the poor psychological function group and the good psychological functiongroup according to the psychological function in patients undergoing maintenance hemodialysis. The biochemical parameters hemoglobin (Hb), total protein (TP), albumin (Alb), prealbumin (PA), serum creatinine (SCr), blood urea nitrogen (BUN), serum calcium (Ca), brain-derived neurotrophic factor (BDNF) and psychological function evaluated with the psychiatric symptom checklist (SCL-90) were compared between the two groups, and correlation analysis was performed. The independent influencing factors of psychological function were analyzed by multiple Logistic regression analysis. Results: There were significant differences of Hb, Alb and BDNF among the three groups (P< 0.05), and there were significant differences of PA, SCr, BUN and Ca between the poor psychological function group and the healthy group (P< 0.05). There was a significant difference of BUN between the good psychological function groupand the healthy group (P< 0.05), but there was no significant difference in TP among the three groups (P> 0.05).The SCL-90 score of poor psychological function group was higher than that of the good psychological function group and the healthy group, with significant differences between groups (P< 0.01).Hb, Alb and BDNF were independent factors influencing the psychological function in patients undergoing maintenance hemodialysis(P< 0.05). Conclusion: There are great differences in biochemical indexes and psychological functionbetween patients undergoing maintenance hemodialysisand healthy people. Hb, Alb and BDNF are important factors influencing the psychological function in patients undergoing maintenance hemodialysis, and relevant indicators should be monitored in clinical practice.
2018 Vol. 24 (3): 520-524 [Abstract] ( 90 ) HTML (1 KB)  PDF (1346 KB)  ( 303 )
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