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2018 Vol. 24, No. 2
Published: 2018-02-28
177
Effects of Rho-Associated Kinase on High Glucose-Induced Murine Heart Endothelial Cell Senescence
XU Changwu, QIU Liqiang, JIANG Hong
DOI: 10.3969/j.issn.1006-6233.2018.02.001
Objective:
To investigate the role of Rho-associated kinase in the high glucose-induced murine heart endothelial cells (MHECs) senescence.
Methods:
MHECs senescence was induced by culturing with 22 mM glucose for 72 h. MHECs in control group were treated with normal culture media and the MHECs in High glucose (HG) group were treated with 22 mM glucose. MHECs in Y27632 group were pretreated with Rho-associated kinase inhibitor Y27632 before cultured in high glucose. In addition, mannitol was added to exclude the effect of osmotic pressure. The ratio of senescent cells was identified by senescence-associated β -galactosidase (SA-βG) staining and flow cytometry was used to analyze the cell cycle. The expression of senescence associated protein p21, p-MBS(Thr853) and MBS was explored by Western blot. The telomerase activity in endothelial cells and the level of nitric oxide (NO) in culture medium assay kit were detected with respective kits.
Results:
Compared to the control group, treatment of high glucose could significantly increase the ratio of SA-βG positive cells (44.00%±3.63% vs. 4.17%±0.70%,P＜0.01), enhance ROCK activity, increase the ratio of cells in G0/G1 stage and the expression of p21, inhibit telomerase activity of the cells and NO level in culture medium (all P<0.05). However, treatment of ROCK inhibitor Y27632 could greatly inhibit ROCK activity and effectively decrease the ratio of senescent cells (both P<0.05). Also, treatment of Y27632 could decrease the ratio of cells in G0/G1 stage and the expression of p21 and reverse the decrease of telomerase activity and NO level in cells cultured in high glucose medium (all P<0.05).
Conclusion:
Rho related kinase activation is involved in high glucose induced endothelial cell senescence, and inhibition of Rho related kinase can reduce the senescence of endothelial cells induced by high glucose, and provide a new direction for the prevention and treatment of diabetic angiopathy.
2018 Vol. 24 (2): 177-181 [
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86
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181
Meta Analysis of the Relationship between the Quality of Life and Social Support for the Elderly in China
LEI Cheng, DAI Fengling, LUO Jing, et al
DOI: 10.3969/j.issn.1006-6233.2018.02.002
Objective:
To systematically evaluate the correlation between quality of life and social support in Chinese elderly by meta analysis.
Methods:
Chinese database includes CNKI and VIP Chinese journals database, Wanfang database and China biomedical database computer retrieval; embase and PubMed database were searched from inception to September 2017. The literature on the correlation between quality of life and social support was evaluated by retrieving the subjects of Chinese aged people. After screening literature, extracting data and evaluating the quality of the study, the RevMan 5.3 software was used for Meta analysis.
Results:
Totally 425 relevant studies were searched and 12 studies were included in the final analysis. The meta-analysis suggested that the total score of quality of life of the Chinese elderly were positively correlated with social support and its three dimensions, but the correlation between the two indicators at a weak correlation level. Among the three dimensions of social support, the correlation coefficient between subjective support and quality of life is the highest, the second is the support utilization, and the correlation coefficient between objective support and quality of life is the lowest.
Conclusion:
Social support may improve the quality of life of the elderly in China to a certain extent.
2018 Vol. 24 (2): 181-188 [
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77
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188
Comparative Analysis of the Effect of Artificial Femoral Head Replacement and PFNA in the Treatment of Unstable Intertrochanteric Fractures in Elderly Patients
LI Zhongtan
DOI: 10.3969/j.issn.1006-6233.2018.02.003
Objective:
To analyze and compare the artificial femoral head replacement and PFNA in the treatment of unstable intertrochanteric fractures in elderly patients.
Methods:
From January 2012 to January 2016, 60 elderly patients with unstable intertrochanteric fracture were selected as the research objects, and they were divided into two groups according to the selected surgical methods. The control group was treated with PFNA internal fixation, and the observation group was treated with artificial femoral head replacement. The general operation indexes of the two groups were observed and compared, and the Harris scores and postoperative complications of the two groups were compared.
Results:
The loading time and length of stay in the observation group were significantly lower than those in the control group; But the operation time and intraoperative blood loss were significantly greater than those in the control group, the difference was statistically significant (P<0.05). After treatment, the total incidence of complications in the observation group was 17.14%, which was significantly lower than that in the control group (40%), and the difference was statistically significant (P<0.05). The difference between the two groups was statistically significant. After treatment, observation group patients with hip Harris score was significantly higher than the control group, the difference was statistically significant (P<0.05); Harris hip score was slightly higher than that of the control group after 6 months.
Conclusion:
Artificial femoral head replacement surgery can help patients reduce the bed time, early recovery of walking function and self-care ability, reduce complications, improve the quality of life of patients. Therefore, the elderly patients with unstable intertrochanteric fracture can be treated with artificial femoral head replacement.
2018 Vol. 24 (2): 188-192 [
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56
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192
Distribution of Pathogenic Bacteria and Risk Factors of Pulmonary Infection in Children after Abdominal Surgery
YANG Qian, LIU Jie
DOI: 10.3969/j.issn.1006-6233.2018.02.004
Objective:
To analyze the pathogenic bacteria distribution and risk factors of postoperative pulmonary infection in children with abdominal surgery.
Methods:
The clinical data of 835 cases of children with abdominal surgery in our hospital from April 2013 to April 2017 were retrospectively analyzed. The pathogenic bacteria in 91 cases of children with pulmonary infection were identified, and the pathogenic bacteria distribution was recorded, and the risk factors for children with postoperative pulmonary infection were analyzed.
Results:
Among 91 cases of children with postoperative pulmonary infection, there were 47 cases (51.65%) with mixed infection and 44 cases (48.35%) with pure infection, and 230 specimens were obtained and 88 pathogenic bacteria strains were detected. There were 49 strains (55.68%) of gram-negative bacteria, 31 strains (35.23%) of gram-positive bacteria and 8 strains (9.09%) of fungi, and the acinetobacterhaemolyticus, klebsiellapneumoniae, staphylococcus haemolyticus and staphylococcus aureus were the main pathogenic bacteriaan. They accounted for 18.18%, 14.77%, 14.77% and 11.36% respectively. Surgical methods, surgical site, congenital heart disease, albumin level before surgery, whether to use antibiotics before surgery, postoperative mechanical ventilation time, invasive operation, chronic respiratory diseases were the risk single factors affecting the postoperative pulmonary infection in children with abdominal surgery (P<0.05). The albumin before surgery,postoperative mechanical ventilation time, invasive operation and chronic respiratory diseases were independent risk factors for postoperative pulmonary infection in children with abdominal surgery (P<0.05).
Conclusion:
Gram-negative bacteria are the main pathogenic bacteria of postoperative pulmonary infection in children with abdominal surgery, and the pulmonary infection is related to the preoperative albumin level before surgery, postoperative mechanical ventilation time, invasive operative, chronic respiratory diseases and other factors, and the clinical application should take effective preventive measures against various risk factors.
2018 Vol. 24 (2): 192-196 [
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87
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197
Relationship between Blood Magnesium Level and Cardiac Valve Calcification in Maintenance Hemodialysis Patients
SHEN Kangkang, WANG Jingfu, ZHANG Baohong, et al
DOI: 10.3969/j.issn.1006-6233.2018.02.005
Objective:
To explore the relation between serum magnesium and cardiar valve calcification(CVC) in maintenance hemodialysis(MHD) patients.
Methods:
Patients with age≥18 years old,maintenance hemodialysis for ≥ 3 months were enrolled in this study.We collected their clinical data and blood biochemical indexes,CVC was measured by echocardiography. Logistic regression was used to analyze the relation between serum magnesium and CVC.
Results:
①Among 149 MHD patients, serum magnesium average was 1.08±0.16mmol/L and 100 cases were high serum magnesium (67.1%),49 cases were normal serum magnesium(32.9%).98 cases were with CVC (65.8%). There were 60 cases with CVC (60.0%) in the high blood magnesium group, which were significantly lower than those 38 with CVC in the normal serum magnesium. ②Age, dialysis age, coronary heart disease, correction of calcium and serum scale were significantly higher in CVC group than non-CVC group (P <0.05). Serum magnesium level and the incidence of high serum magnesium were significantly higher in non-CVC group than CVC group (P <0.05). ③Logistic regression analysis dispaly: Serum magnesium was independent negatively associated with CVC (P = 0.001); age , dialysis age, serum phosphorus were independent positively associated with CVC (P＜0.05). Serum magnesium was independently negatively associated with MVC,AVC,MVC and AVC (P＜0.05). Serum phosphorus was independently positively associated with MVC, AVC, MVC and AVC (P＜0.05). Dialysis age was independently positively associated with MVC (P＜0.05). Age was independently positively associated with AVC (P＜0.001).
Conclusion:
The higher prevalence of serum magnesium, the higher serum magnesium and CVC in MHD patients, high serum magnesium can reduce the incidence of CVC in MHD patients; high serum phosphorus is an independent risk factor for CVC.
2018 Vol. 24 (2): 197-201 [
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87
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202
The Effect of Individualized Treatment on the Prognosis of Elderly Patients with Chronic Heart Failure
HUANG Zhigang, LI Yan
DOI: 10.3969/j.issn.1006-6233.2018.02.006
Objective:
To investigate the effect of geriatric comprehensive assessment intervention on the prognosis of hospitalized elderly patients with chronic heart failure, so as to provide reference for the health protection of elderly patients.
Methods:
During the period of January 2014 to January 2016, 220 inpatients with CHF were included in this study as the research object, randomly divided into control group and observation group, 110 cases in each group. The control group was given routine drug treatment and symptomatic treatment, the observation group was given comprehensive evaluation of the elderly, and the multidisciplinary treatment was organized according to the evaluation results, and individual treatment program was formulated. Two groups of patients were followed up for 1 year. The mortality, readmission rate, emergency visit rate, cardiac function, cognitive function and quality of life were compared and analyzed.
Results:
The mortality, readmission rate and emergency visit rate of the observation group were 8.18%, 23.64% and 16.36%, respectively, which were lower than 19.09%, 38.18% and 30% of the control group (P<0.05); After the intervention, the LVEF of the observation group was (51.25±6.68), which was significantly higher than that of the control group (46.71±5.87) (P<0.05); The C-MLHF score was (37.61+6.51), which was significantly lower than that of the control group (45.51±5.59) (P<0.05); The MoCA score was (24.51±2.87), which was significantly higher than that of the control group (22.59±2.91)(P<0.05).
Conclusion:
The elderly intervention after comprehensive geriatric assessment can significantly reduce the mortality, readmission rate, emergency treatment rate, improve cardiac function, cognitive function and quality of life, and improve the prognosis of elderly patients with chronic heart failure, which is worthy of clinical use.
2018 Vol. 24 (2): 202-205 [
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206
Comparison of Efficacy of two Chemotherapy Regimens for Acute Lymphoblastic Leukemia in TEL-AML1 Fusion
ZHANG Aiming
DOI: 10.3969/j.issn.1006-6233.2018.02.007
Objective:
To compare the difference of clinical efficacy between BCH-2003 program and CCLG-2008 regimen in the diagnosis of acute lymphoblastic leukemia (molecular marker TEL-AML1), so as to provide reference for clinical children to choose appropriate diagnosis and treatment plan according to the actual condition.
Methods:
From August 2012 to December 2015, 120 cases of children with acute lymphoblastic leukemia who were hospitalized for chemotherapy in our hospital were enrolled in the study. They were treated by BCH-2003 program and CCLG-2008 program. The children in each group were 60 cases, respectively. The molecular biological markers were TEL-AML1. The statistical differences in the recurrence of the two groups, the plasma related biochemical indexes (VEGF, VEGFR, bFGF, MVD), and the clinical efficacy were compared.
Results:
The changes of VEGF, VEGFR, bFGF and MVD were significantly changed (P<0.05) before and after treatment in the two groups. After treatment, the differences of VEGF, VEGFR and MVD in the two groups were statistically significant (p<0.05). The difference of clinical efficacy between the two groups was statistically significant (P<0.05). The difference of adverse reactions between the two groups was statistically significant (P<0.05). The difference of the risk of recurrence of the two groups was statistically significant (P<0.05), and the difference of the immunophenotype of the two groups was statistically significant (P<0.05). The recurrence of the two groups was compared, and the differences in risk, immune classification and recurrence were statistically significant (all P<0.05).
Conclusions:
The short term clinical efficacy of the BCH-2003 regimen is better than the CCLG-2008 scheme in the treatment of children with TEL-AML1 fusion gene positive acute lymphoblastic leukemia. However, the incidence of adverse reactions and the severity of relapse in the CCLG-2008 regimen were better than that of the BCH-2003 regimen.
2018 Vol. 24 (2): 206-211 [
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211
The Efficacy of Aspirin in the Treatment of Primary Hypertension with CHD and its Effect on Plasma Viscosity and Platelet Aggregation Rate
CUI Linlin, GAO Guojie, HU Taohong
DOI: 10.3969/j.issn.1006-6233.2018.02.008
Objective:
To observe the curative efficiency of aspirin on primary hypertension combined with coronary heart disease(CHD) and its influence on plasma viscosity and platelet aggregation rate.
Methods:
A total of 107 cases of primary hypertension patients with coronary heart disease were randomly divided into two groups by the random number table method: the study group (56 cases) and the control group (51 cases). The control group were given Telmisartan (40mg/d), Isosorbide Dinitrate tablets (30mg once, 3 times per day), while the study group were given aspirin (100mg/d) on the basis of the control group. Compare the blood pressure, blood lipid levels, left ventricular ejection fraction (LVEF), plasma viscosity and platelet aggregation rate changes of the two groups before and after 6 months' treatment.
Results:
After 6 months' treatment, the level of blood pressure, TC, TG, plasma viscosity and platelet aggregation rate of both groups were all declined on different degree, while the level of plasma viscosity and platelet aggregation rate of the study group were more significant lower than that of the control group (P<0.05). In addition, the LVEF of both groups were all increased significantly (P<0.01), and the LVEF level of the study group were significantly higher than the control group (P<0.05); the total effective rate of the study group were significantly higher than the control group (90.9% vs 76.5%, P<0.05).
Conclusion:
The therapy of aspirin can improve the blood viscosity and LVEF level for primary hypertension patients with CHD, and improve the curative efficiency as well.
2018 Vol. 24 (2): 211-215 [
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87
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215
Effect of Small Tidal Air Volume Lung Protective Ventilation on PostoperativeReintegration of Catients with Incomplete Gastroenteral Surgery for Elderly combined with Pulmonary Dysfunction
GAO Dehong
DOI: 10.3969/j.issn.1006-6233.2018.02.009
Objective:
To provide guidance for the patients with anesthesia ventilation in the selection process by understanding of gastrointestinal surgery used in lung protective ventilation with low tidal volume to the elderly pulmonary insufficiency results and analysis of the method of difference between the traditional mechanical ventilation.
Methods:
From February 2012 to December 2016, 140 cases of gastrointestinal surgery admitted in our hospital were randomly divided into control group (traditional mechanical ventilation group) and experimental group (protective ventilation management group), with 70 patients in each group. The operation related indicators (Pplat, Ppeak, PErCO
2
, Raw, anesthesia time, operative time, operative bleeding volume, transfusion volume and urine volume) of the two groups before and after operation (T
0
-T
4
) were compared. The statistical difference of airway monitoring index, oxygen saturation and related indicators (PaO
2
, PaCO
2
, OI, Qs/Qt), inflammatory cytokines and related indicators (IL-6, IL-8, TNF-α, CC16, SP-D, sRAGE) of two groups were compared.
Results:
The differences of Pplat, PErCO
2
, Raw, time of anesthesia, operation time and bleeding volume of the two groups were statistically significant (P<0.05). The Pplat, PErCO
2
and Raw in the experimental group were larger than those in the control group, and the time of anesthesia, the operation time and the amount of bleeding were less than those of the control group. The difference of P peak, P average and CL index in the experimental group and the control group was statistically significant (P<0.05). The difference of P peak (T
1
, T
2
, T
3
), P average (T
2
, T
3
), CL (T
2
, T
3
, T
4
) between the two groups were statistically significant (P<0.05). The overall index of the experimental group was less than that of the control group. The differences of PaO
2
, PaCO
2
, OI and Qs/Qt in the experimental group and the control group were statistically significant (P<0.05). The differences of PaO
2
(T
2
, T
3
, T
4
), PaCO
2
(T
1
, T
2
, T
3
, T
4
) and Qs/Qt between the two groups were statistically significant. The PaO
2
, PaCO
2
, OI and Qs/Qt in the control group were less than those in the experimental group. The differences of IL-6, IL-8, TNF- alpha, CC16, SP-D and sRAGE in the experimental group and the control group were statistically significant (P<0.05). The difference of IL-6 (T
1
, T
2
), TNF- alpha (T
1
, T
2
, T
3
, T
4
), CC16 (T
1
, T
2
, T
3
), and the index of between the two groups were statistically significant. The TNF-alpha, CC16 and SP-D in the control group were higher than those in the experimental group, but the sRAGE was less than the experimental group.
Conclusions:
Gastrointestinal surgery in elderly patients with pulmonary insufficiency, lung protective ventilation of low tidal volume, compared to conventional mechanical ventilation can reduce the severity of inflammation, better protect the airway function and blood gas status and safety of anesthesia.
2018 Vol. 24 (2): 215-222 [
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Evaluation of Early Carotid Elastic Function in Patients with Hypertension by ET Technique
CHEN Xiuming
DOI: 10.3969/j.issn.1006-6233.2018.02.010
Objective:
To explore value of E-tracking (ET) technology in evaluating the carotid elasticity in hypertensive patients.
Methods:
Seventy-eight hypertensive patients were divided into two groups according to the intima-media thickness(IMT)of carotid artery, group A (36 cases): IMT≤1.0mm, group B (42 cases): IMT>1.0mm,and normal control group (75 cases). Using ET technology to track the movement of common carotid arterial wall and measure the parameters: stiffness parameters (β), elastic coefficient (Ep), and arterial compliance (AC).
Results:
The values of Ep and β in group A and group B were significantly higher than those in control group. The AC values in group A and group B were lower than those in control group, and there were also significant differences. The values of Ep and β in group B were higher than those in group A, there was a significant difference between the two groups, while the AC value was lower than that in group A, with significant difference.
Conclusions:
ET technology can reflect the vascular endothelial function earlier. It is a simple and useful method in evaluating the vascular changes of hypertensive patients.
2018 Vol. 24 (2): 222-224 [
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56
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225
The Timing of Operation on the Prognosis of Patients with High Grade Aneurysm Microscopy
YANG Xinchao, YU Qibing, LIU Zhengchen, et al
DOI: 10.3969/j.issn.1006-6233.2018.02.011
Objective:
To investigate the effect of microsurgical clipping time on prognosis of patients with high grade intracranial aneurysms.
Methods:
The clinical data of 80 patients with Hunt-Hess III ~ IV intracranial aneurysms treated by microclipping in our department of neurosurgery from January 2012 to May 2017 were retrospectively analyzed. According to the onset time of patients with operation time, divided into 40 cases of early (0 ~ 3), 40 cases of late (more than 8) two subgroups. The general data of two groups of surgical patients, factors associated with postoperative outcomes, postoperative complications and the outcome of the two groups after 6 months of operation were observed.
Results:
In the early group and the late group, the difference was statistically significant (P < 0.05) in the Fisher classification, the delayed ischemic nerve dysfunction and the good outcome.
Conclusion:
The prognosis of the patients with high grade intracranial aneurysm with early operation is better than that of late operation.
2018 Vol. 24 (2): 225-228 [
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228
Study on the Effect of Salvia Miltiorrhiza Ligustrazine Injection in the Treatment of Refractory Hypertension in Elder in Serum CRP and Homocysteine
MA Jianlin, WANG Xiaohong, LI Chunmei, et al
DOI: 10.3969/j.issn.1006-6233.2018.02.012
Objective:
To investigate the effect of Salvia miltiorrhiza Ligustrazine Injection in the treatment of Refractory hypertension in elder in serum CRP and homocysteine.
Methods:
90 cases with refractory hypertension in our hospital were selected and divided into 2 groups, 44 cased in the control group received irbesartan and hydrochlorothiazide treatment, 44 cases in the treatment group received more with Salvia miltiorrhiza Ligustrazine Injection treatment, a total of 14 days treatment. Changes of laboratory indexes were compared to explore the clinical effect and mechanism of the Salvia miltiorrhiza Ligustrazine Injection in the treatment of Refractory hypertension.
Results:
After 14 days of treatment, diastolic blood pressure and systolic blood pressure in 2 groups were significantly decreased than before(P<0.05), and the average blood pressure in the treatment group was lower than the control group(P<0.05). After 14 days of treatment, the total effective rate of the treatment group was significantly higher than the control group(P<0.05). Before treatment, two groups of CRP, Hcy, whole blood viscosity, whole blood low shear viscosity was no significant difference after treatment, CRP, Hcy, whole blood viscosity, whole blood low shear viscosity of treatment group improvement were better than the control group, there was significant difference between two groups. (P<0.05).
Conclusion:
Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection adjuvant therapy can significantly improve serum CRP and homocysteine levels in patients with refractory hypertension, and it has good clinical therapeutic effect.
2018 Vol. 24 (2): 228-232 [
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232
Serum OPG in Patients with Polycystic Ovary Syndrome and its Clinical Significance
DENG Yuehong
DOI: 10.3969/j.issn.1006-6233.2018.02.013
Objective:
To investigate the serum level of serum retinin and its clinical significance in patients with polycystic ovary syndrome (PCOS).
Methods:
120 patients with PCOS admitted to our hospital from January 2016 to July 2016 were enrolled as PCOS group and 120 healthy volunteers were enrolled in this study as healthy control group. Meanwhile, Luteotropic hormone (LH), follicle stimulatin hormone (FSH), testosterone (T), estradiol (E2) and pituitary prolactin (PRL) Fasting serum insulin (FINS) and fasting blood glucose (FBG) were measured. The levels of homeostasis model assessment-insulin resistance (HOMA-IR) and serum retinal omentin.
Results:
The levels of serum LH and T in PCOS group were significantly higher than those in healthy control group (P <0.05), while the levels of serum FSH in PCOS group were significantly lower than those in healthy control group (P <0.05). The levels of FINS and HOMA-IR in PCOS group were higher (P <0.05). The level of serum Omentin in patients with PCOS was lower than that in healthy controls (P <0.05). The level of serum Omentin was negatively correlated with HOMA-IR index in patients with PCOS (R2 = 0.798; P <0.001) .
Conclusions:
The decline of serum Omentin will lead to the rise of insulin resistance and indirectly affect the blood glucose level of PCOS patients. It may be used as an adjunctive therapy for PCOS patients as the relevant laboratory index.
2018 Vol. 24 (2): 232-235 [
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235
Effects of Monotherapy and Dual Antiplatelet Therapy on Vascular Endothelial Function and Inflammatory Factors after Drug-eluting Stent Implantation
GUO Qing, YE Hong
DOI: 10.3969/j.issn.1006-6233.2018.02.014
Objective:
To investigate the effect of different antiplatelet regimens on vascular endothelial function and inflammatory factors after drug-eluting stent implantation.
Methods:
300 patients with coronary heart disease and came to our hospital for drug eluting stent implantation from January 2015 to December 2016 were enrolled and randomly divided into monotherapy group and dual antiplatelet therapy group. Monotherapy group receive clopidogrel antiplatelet treatment whereas dual antiplatelet therapy group receive clopidogrel plus aspirin in the treatment. The vascular endothelial function indexes such as ET-1, NO and inflammatory factors such as TNF-a, IL-1, CRP were compared between the two groups at the time before operation, 12 hours after operation and 30 days after operation.
Results:
After operation, the levels of ET-1, TNF-a and CRP increased significantly, and NO decreased significantly. After 30 days antiplatelet treatment, the levels of ET-1, TNF-a and CRP decreased, and NO increased. Besides, ET-1 and CRP levels in dual antiplatelet therapy group were less than monotherapy group at 30 days after operation and they change more in dual antiplatelet therapy group. Level of TNF-a showed no significant difference between the two group, however, dual antiplatelet therapy group showed greater reductions than monotherapy group (P<0.05).
Conclusion:
Compared with clopidogrel monotherapy, clopidogrel plus aspirin can improve the vascular endothelial function and reduce the inflammatory reaction in patients after drug-eluting stent implantation.
2018 Vol. 24 (2): 235-239 [
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86
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239
Effect of the Intermittent Pneumatic Compression on the Deep Venous Thrombosis of Lower Limb in ICU Patients
CHEN Yajing, HAN Guijun
DOI: 10.3969/j.issn.1006-6233.2018.02.015
Objective:
To explore the effect of IPC on the prevention of DVT.
Methods:
48 patients admitted to the intensive care unit due to ARDS were selected and randomly divided into two groups: control group and experimental group, the control group using drug anticoagulant prevention; experimental group given the application of IPC. The blood coagulation function of the patients was observed and the color Doppler ultrasound was used to examine the thrombosis of the lower extremities, and the preventive effect of the two groups was judged.
Results:
The difference between the two groups of the activated partial thromboplastin time, prothrombin time, fibrinogen, ultrasound examination results had significant difference (P < 0.05).
Conclusions:
The intermittent pneumatic compression can improve the coagulation function of patients and prevent the formation of deep vein thrombosis in ICU patients.
2018 Vol. 24 (2): 239-242 [
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65
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242
Effects of Different Anesthetic Methods on Neutrophils and Lymphocytes after Breast Cancer Surgery
LING Hua, et al
DOI: 10.3969/j.issn.1006-6233.2018.02.016
Objective:
To observe the suction compound anesthesia with intravenous anesthesia and two different anesthetic methods for breast cancer postoperative neutrophils and lymphocytes.
Methods:
A prospective study was conducted. 100 patients with breast cancer were randomly divided into two groups. Group A (n=50) received total intravenous anesthesia, group B (n=50) received static inhalation combined anesthesia. The changes of neutrophils count (N), lymphocyte count (L) and neutrophils / lymphocyte ratio (NLR) were compared before and after the operation.
Results:
There was significant difference in serum N, L and NLR values between the two groups before and after operation (P < 0.05). There was no significant difference in the value of N, L and NLR between the two groups after operation (P > 0.05).
Conclusion:
Two different ways of total intravenous anesthesia and intravenous inhalation combined anesthesia have slight effect on the N, L and NLR value of breast cancer after operation. It is suggested that anesthesia should be chosen according to the actual situation of patients.
2018 Vol. 24 (2): 242-245 [
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78
)
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245
Analysis of the Curative Effect and Daily Living Standard of Closed Reduction Intramedullary Nail and Open Reduction Plate Fixation in the treatment of Middle Clavicular Fracture
LIU Gang
DOI: 10.3969/j.issn.1006-6233.2018.02.017
Objective:
To study and compare the clinical effect of closed reduction intramedullary nail and open reduction and plate fixation for the treatment of clavicular fracture.
Methods:
During January 2013 to July 2016, 100 cases of clavicle fracture patients who received in the hospital were selected and randomly divided into two groups by taking computer single blind randomized grouping method, 50 cases in each group. Group A was treated with closed reduction and intramedullary nail fixation. Group B was treated with open reduction and plate fixation. The operation, prognosis and quality of life were compared between two groups.
Results:
The intraoperative blood loss and operative time in group A were significantly less than group B (P<0.05), the fracture healing time was significantly shorter than group B (P<0.05); the complication rate in group A was higher than group B (P<0.05); after the operation, the CM score in two groups was significantly better than those before operation (P<0.05), and two groups after surgery had no significant difference (P>0.05).
Conclusion:
Closed reduction and intramedullary nail fixation and open reduction and plate fixation of clavicle can effectively improve shoulder joint function in patients with clavicle fractures, each has its advantages and disadvantages, clinicians should choose a fixed way according to the specific circumstances of patients.
2018 Vol. 24 (2): 245-248 [
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68
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248
The Evaluation of Multi-slice Spiral CT Cardiac Function in the Evaluation of Coronary Artery Bypass Grafting
WAN Liye, CUI Zhixin, WANG Shenglin, et al
DOI: 10.3969/j.issn.1006-6233.2018.02.018
Objective:
To detect left ventricular function before and after coronary artery bypass grafting in patients with coronary artery disease with multi slice spiral CT (MSCT) and to evaluate the treatment effect after CABG.
Methods:
A retrospective analysis of 38 patients (86 branches of bridging vessels) was performed by Ejection-Fraction software, volume rendering (VR) and multiplanar reformation (MPR). The changes of left ventricular function before and after coronary artery bypass graft surgery were analyzed, and the plaque formation and restenosis in the bridge were observed.
Results:
Multi slice spiral CT showed that 8 patients (8.1%) had restenosis caused by intravascular thrombosis, and 2 (2.3%) were completely obliterate. Postoperative left ventricular ejection fraction was significantly improved compared with that before operation (44.13 + 8.52 VS 39.26 + 7.46, P < 0.05). The change rate of left ventricular function index EF was 10.79 + 7.81 after operation, and 8 cases (total 9) had stenosis of bridge vessel, and the rate of change of EF was 6.87 + 4.71.
Conclusion:
Multi slice spiral CT can clearly observe the bridge vessels and detect left ventricular function at the same time, so as to evaluate the curative effect of coronary artery bypass grafting. It is a reliable examination method.
2018 Vol. 24 (2): 248-251 [
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68
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251
The Efficacy of Metformin and Rosuvastatin in the treatment of Newly Diagnosed Type 2 Diabetes Mellitus
GONG Min, WANG Aihua
DOI: 10.3969/j.issn.1006-6233.2018.02.019
Objective:
To investigate the efficacy of combination of metformin and rosuvastatin in the treatment of newly diagnosed obese type 2 diabetes mellitus.
Method:
90 newly diagnosed obese type 2 diabetic patients admitted to hospital from July 2015 to November 2016 were randomly divided into two groups. Patients in the control group were treated with metformin, while patients in the observation group were given rosuvastatin. The patients in the two groups were compared Patient disease-related parameters, overall treatment effect and quality of life.
Result:
The levels of BMI, SBP, FBG, 2hPG, HbAlc, HOMA-IR, IMT, TC, TG and LDL-C in the observation group were significantly lower than those in the control group, FCP, FMD and HDL-C were significantly higher than the control group; 6 months after treatment, the total quality of life scores were significantly higher than the control group, there was a significant difference (P <0.01); total effective rate was significantly higher than the control group, there was significant Difference (P <0.05).
Conclusion:
The combination of metformin and rosuvastatin is of great value in the treatment of newly diagnosed obesity type 2 diabetes.
2018 Vol. 24 (2): 251-255 [
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233
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255
Effects of Ischemic Preconditioning and Collateral Circulation on Short-term Prognosis in Patients with Acute Myocardial Infarction Complicated with Diabetes Mellitus
ZHANG Junyi, ZHAO Kaidi, MA Ying, et al
DOI: 10.3969/j.issn.1006-6233.2018.02.020
Objective:
To investigate the effects of myocardial ischemic preconditioning (IP) and coronary collateral circulation (CR) on the short-term prognosis of patients with acute myocardial infarction (AMI) complicated with diabetes mellitus.
Methods:
Retrospective analysis of diabetic patients with acute myocardial infarction in 115 cases, according to the 48 hours of pre infarction angina pectoris divided into ischemic preconditioning group (IP group, n=69) and non-ischemic preconditioning group (group NIP, n=46). The two groups were divided into subgroups (A group, B group, C group, D group) according to the collateral circulation (CR). The baseline data, myocardial infarct size, left ventricular ejection fraction and 6 months follow-up . The incidence of death, severe arrhythmia, left ventricular function and other adverse reactions were compared between the two groups.
Results:
The peak value of CK and CK-MB in group A were significantly lower than that in group D(P<0.05). The A in group LVEF was significantly higher than that in other groups(P<0.05). Incidence of adverse reactions of A group was lower than that of B group, C group, D group (P<0.05); B group, C group of patients with adverse reaction rate was significantly lower than that in D group, the difference was statistically significant (P<0.05).
Conclusions:
In patients with acute myocardial infarction complicated with diabetes mellitus, myocardial ischemic preconditioning and collateral circulation can play a protective role in myocardial infarction and improve the prognosis.
2018 Vol. 24 (2): 255-258 [
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65
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258
Observation of Therapeutic Effect of Visual and Audio-visual combined Intervention on Vascular Vagus Reflex during Hemorrhoidectomy
LIU Xiaoli, JIA Guopu, ZHAO Honglian, et al
DOI: 10.3969/j.issn.1006-6233.2018.02.021
Objective:
To explore a method to reduce the reflexes of the vagus nerve in patients with hemorrhoids.
Methods:
A single center randomized controlled clinical trial was conducted. 200 patients undergoing hemorrhoidal mucosal circumcision were randomly divided into experimental group (100 cases) and control group (100 cases). During the operation, the control group received routine nursing, while the experimental group was given audio-visual intervention combined with dispersal. On the basis of this, the changes of vital signs and the number of vasovagal reflexes in the two groups were observed and compared.
Results:
Compared with the control group, the vital signs of the experimental group were relatively stable during the operation, and the difference was statistically significant. The number of vascular vagus nerve reflex (8 cases) in the experimental group was significantly less than that of the control group (18 cases), and the difference was statistically significant (P<0.05).
Conclusion:
For patients with hemorrhoids and mucous membrane circumcision, the combination of audio-visual intervention can effectively reduce the occurrence of adverse reactions such as vasovagal reflex and stable vital signs, which is of great significance for the smooth operation and ensuring the safety of patients.
2018 Vol. 24 (2): 258-261 [
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96
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262
The Predictive Value of the Ratio of Blood Lipid Index to Simple Postprandial Hyperglycemic Diabetes
TANG Jinmei, BI Tingting, ZHOU Qian, et al
DOI: 10.3969/j.issn.1006-6233.2018.02.022
Objective:
To investigate and compare predictive diagnostic value of TG/HDL-C, TC/HDL-C, non-HDL-C ratios for isolated post-challenge hyperglycemia (IPH).
Methods:
220 patients with IPH and 216 normal glucose tolerances (NGT) were enrolled in this study. All subjects were underwent a75-g OGTT. Their clinical, lipid and glucose were measured and calculated TG/HDL-C, TC/HDL-C, non-HDL-C ratios.
Results:
Compared with NGT, patients with IPH had higher blood pressure, BMI, waist circumference, TC, TG, LDL-C,TG/HDL-C, TC/HDL-C,non-HDL-C and 2h-PG, with lower HDL-C (P<0.05). According to logistic regression analysis, after adjusted for the age, blood pressure, BMI, waist circumference and FBG, TC, TG, LDL-C, TC/HDL-C, TG/HDL-C, and non-HDL-C were all positively correlated with IPH. TG/HDL-C obtained the highest area under the curve (AUC) of 0.832 determined by ROC curves, suggesting that TG/HDL-C has the greatest diagnostic value of IPH. The cut off value of TG/ HDL-C was set at 1.42, with the sensitivity of 81.90% and the specificity of 69.20%.
Conclusion:
TG/HDL-C has the greatest diagnostic value of IPH, patients whose TG/HDL-C is over 1.42 need further test of OGTT in order to diagnose IPH earlier.
2018 Vol. 24 (2): 262-266 [
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48
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266
Effect of Hyperbaric Oxygen Therapy on Cognition, Speech and Exercise Ability in Children with Early Cerebral Palsy
XIAN Ying, TAN Lijuan, FAN Jinlian, et al
DOI: 10.3969/j.issn.1006-6233.2018.02.023
Objective:
To study the effect of hyperbaric oxygen therapy on cognitive, speech and language abilities in children with early cerebral palsy.
Methods:
61 cases of early cerebral palsy patients admitted to our hospital during the period from June 2014 to June 2017 as an example, which were randomly divided into two groups, the observation group of 31 cases, treated with routine therapy and hyperbaric oxygen combined treatment; 30 patients in control group were used routine treatment method. The effects of MMSE (simple mental scale), CRRC version of children's language development retardation assessment (S-S), and (GMF) total motor function score on cognitive, verbal and motor ability of patients were evaluated.
Results:
Using the conventional method of hyperbaric oxygen combined treatment of the two groups of patients after treatment, GMF score decreased significantly, S-S score and MMSE score after treatment increased, there was no significant difference between the two groups of patients before treatment, before and after treatment, there were significant differences between the two groups (P<0.05).
Conclusion:
For children with early cerebral palsy, the hyperbaric oxygen therapy based on routine treatment can significantly improve their cognition, speech and motor ability, which is worthy of popularization and application.
2018 Vol. 24 (2): 266-269 [
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66
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283
Laboratory Analysis of Irregular Antibodies in Rh Blood Group System Causing Hemolytic Disease of The Newborn
ZHAO Qian, WANG Zhenlei, HE Lujun, et al
DOI: 10.3969/j.issn.1006-6233.2018.02.028
Objective:
To analyze the distribution of all kinds of irregular antibodies causing hemolytic disease of the newborn (HDN) in Rh blood group system to provide important basis for clinical prevention, diagnosis and the treatment of Rh-HDN.
Methods:
The ABO and Rh blood group identification (neonatal ABO blood group identification was done only by positive test) by the tube method. Three tests of neonatal hemolysis were carried out by microcolumn gel method. The antibody screening and antibody identification were carried out by microcolumn gel method and polyamine method. The application of 2 test were compared between the two groups.
Result:
In 246 cases of compatible ABO blood type of the parents, there were 61 cases of irregular antibodies detected in Rh blood group system (24.60%), and the distribution of antibodies were anti-D(32 cases), anti-E(2 cases), anti-cE(4 cases), anti-C(3 cases), anti-c(2 cases) and anti-Ce(4 cases) respectively. In 273 cases of incompatible ABO blood type of the parents, there were 25 cases of irregular antibodies detected in Rh blood group system (8.93%), and the distribution of antibodies were anti-D(15 cases), anti-E(2 cases), anti-cE(4 cases), anti-C(2 cases), anti-c(1 case) and anti-Ce(1 case) respectively. The detected number of Rh antibodies in the group without ABO antibodies was higher than the number of the group with ABO antibodies. The differences was statistically significant (P＜0.05).
Conclusion:
Anti-D is still the main cause of Rh-HDN. However, the detection rates of anti -E and anti-cE were also high in other Rh systems, especially in the samples of the same or compatible ABO blood group. We should attach importance to the RhD positive pregnant women. If the ABO blood group is the same or coincide, the screening of unexpected antibodies in Rh blood group system is of great clinical significance for the prevention and early treatment of Rh-HDN.
2018 Vol. 24 (2): 283-286 [
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116
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286
Study on the Feasibility of Preserving Left Colon Artery in Laparoscopic Radical Resection of Rectal Cancer
REN Cong, BAI Wenwu, LUO Zhimin, et al
DOI: 10.3969/j.issn.1006-6233.2018.02.029
Objective:
To explore the feasibility of preserving Left colic artery (LCA) in laparoscopic radical resection of rectal cancer.
Methods:
The clinical data of 102 cases of laparoscopic rectal radical resection admitted in our hospital from July 2014 to January 2017 were retrospectively analyzed, including 36 cases with preservation of LCA (the experimental group)and 66 cases without preservation of LCA(the control group). Through comparing the operative time, blood loss, postoperative exhaust time, pull out time of pelvic drainage tube, the number of lymph nodes removed around the root of inferior mesenteric artery, to get the difference in the surgical outcome between the two groups.
Results:
No significant difference was found in intraoperative blood loss [65 (20-300) vs 70 (10-400) ml, p=0.848], operative time [165 (104-270) vs 183 (100-328) min,p=0.368], pull out time of pelvic drainage tube[12.5 (6-44) vs 13 (7-120),p=0.220], postoperative exhaust time [6 (2-12) vs 6 (2-18), p=0.253], the number of lymph nodes removed around the root of IMA [15.694±2.745 vs 16.288±3.262,p=0.356]between the two groups. 2 cases of anastomotic leakage occurred in the preservation group,while 14 cases of anastomotic leakage occurred in the none-preservation group (p=0.038), there was statistical difference between the two groups (P<0.05), it can be proved that the experimental group can effectively reduce the occurrence of anastomotic leakage.
Conclusion:
The operation of preserving the left colonic artery in laparoscopic radical resection of rectal cancer reduce the incidence of anastomotic leakage and don't increase the risk of operation. It is a safe and feasible operation.
2018 Vol. 24 (2): 286-290 [
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63
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290
The Relationship between Circulating Tumor cells and the Level of Serum Squamous cell Carcinoma Antigen in Patients with Non-small Cell Lung Cancer
LV Xiaowei, LU Haijun
DOI: 10.3969/j.issn.1006-6233.2018.02.030
Objective:
To study the analysis of lung cancer circulating tumor cells and non small cell (NSCLC) in serum of patients with squamous cell carcinoma antigen (SCC-Ag) level.
Methods:
40 NSCLC patients in our hospital from February 2015 to February 2017 as the main research object, and select the health examination in the same period as control 40 group, benign disease and 35 as benign group; through the research object Cell Search system for the detection of circulating tumor cells, and serum SCC-Ag level by ELISA, three groups of results Comparative analysis of NSCLC group.
Results:
the number of circulating tumor cells was significantly higher than that in benign group and control group, the difference was statistically significant (P<0.001), benign group was significantly higher than the control group number of circulating tumor cells (P<0.001); the level of SCC-Ag in group NSCLC was significantly higher than that in benign group and control group, the difference was statistically significant (P<0.001), and benign group SCC-Ag level of control group had no significant difference (P>0.05); group NSCLC number of circulating tumor cells and SCC-Ag levels were positively correlated (r=0.965, P < 0.05).
Conclusion:
It can help to improve the clinical detection rate of NSCLC, and make the patients receive scientific and effective treatment as soon as possible, for the clinical suspected NSCLC patients can detect the number of circulating tumor cells and serum SCC-Ag levels.
2018 Vol. 24 (2): 290-293 [
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81
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293
Study on the Factors of Influencing Fatty Liver in PostmenopausalWomen Complicated with Type 2 Diabetes
GE XiaoChun, WANG YingNan, GAO Yu, et al
DOI: 10.3969/j.issn.1006-6233.2018.02.031
Objective:
To analyze the influencing factors of fatty liver in type 2 diabetic patients with Postmenopausal.
Methods:
From October 2012 to October 2014, the general condition, lifestyle and self-management data of hospitalized patients were collected. 136 cases of postmenopausal type 2 diabetes mellitus with fatty liver were selected as observation group, and 138 cases of postmenopausal patients with type 2 diabetes mellitus as control group. The differences of the data between the two groups were compared.
Results:
There was significant difference between the two groups of high fat diet, high sugar diet, physical exercise and self management index (P < 0.05). Multivariate logistic regression analysis showed that high fat diet (OR = 2.324, 95%CI = 1.409 to 3.833) and high carbohydrate diet (OR = 1.866, 95%CI = 1.118 to 3.114) were risk factors for fatty liver.
Conclusions:
The influencing factors of fatty liver in postmenopausal patients with type 2 diabetes are diet habits, physical exercise and self-management. High glucose and high-fat diet are risk factors for fatty liver.
2018 Vol. 24 (2): 293-296 [
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83
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296
The Establishment of a Nomogram Model of no Streptococcus Infection Risk of Individual Prediction of Pregnant Women in Late Pregnancy
ZENG Xianqin, WANG Lijun, LU Binghuai
DOI: 10.3969/j.issn.1006-6233.2018.02.032
Objective:
To establish the individual nomograms for predicting the risk of GBS infection model by analysis of risk factors related to the infection of Streptococcus lactis (GBS) in pregnant women in late pregnancy.
Methods:
From Jan 2017 to June 2017, 694 late pregnancy women were enrolled in this study. Their clinical data were analyzed and logistic regression model was used to determine the risk factors related to GBS infection. Then the R software was used to establish a predictive nomogram model of GBS infection. Bootstrap method was used to validate the nomogram model and ROC curve was used to explore the predictive efficacy of the model in predicting the GBS infection.
Results:
A total of 68 cases out of 694 cases had GBS infection. The prevalence rate was 9.80%. Age (OR=2.79,95CI%:1.45-5.39), overweight before pregnancy/obesity (R=2.50,95CI%:1.11-5.66), vaginitis (OR=3.71, 95CI%:1.88-7.32), urinary tract infection (OR=2.68, 95CI%:1.25-5.78), and pregnancy with diabetes mellitus (OR=3.14, 95CI%:1.39-7.09) were all independent risk factors for GBS infection (P<0.05). The nomogram model had a C-index of 0.816 with good discrimination and accuracy, and ROC curve showed that the area under the curve (AUC) for the nomogram model predicting GBS infection was 0.832 (95%CI: 0.757-0.899).
Conclusion:
The nomogram built based on age, overweight before pregnancy/obesity, vaginitis, urinary tract infection, and pregnancy with diabetes mellitus has a good discrimination and accuracy which could be helpful for screening the pregnancy women with high risk and setting the interventional plans.
2018 Vol. 24 (2): 296-301 [
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65
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301
Analysis of Psychological Disorders and Influencing Factors in Patients with Systemic Lupus Erythematosus
YU Yao, PANG Dongrui
DOI: 10.3969/j.issn.1006-6233.2018.02.033
Objective:
To investigate the prevalence of psychological disorders in patients with systemic lupus erythematosus (SLE) and analyze the influencing factors.
Methods:
80 patients with SLE treated in our hospital during the period from February 2012 to April 2017 were selected as the subjects, and 80 healthy volunteers who underwent physical examination in our hospital during the same period were also enrolled in the study. All subjects were evaluated with the symptom check list-90 (SCL-90), and the level of mental health was compared between the two groups. According to the results of SCL-90 screening, patients with SLE were divided into mental disorder group and no-mental disorder group. The clinical data such as age, gender, course of disease, recurrence frequency, disease activity, visceral involvement, adverse drug reactions, education level, occupation status, economic income, marital status and residence were compared between groups.
Results:
The total score of SCL-90 of patients with SLE was significantly higher than that of healthy volunteers [(154.29±28.51) vs (132.17±25.69) ](P < 0.05). In 80 patients with SLE, 29 patients had mental disorders detected by SCL-90, and the detection rate was 36.3% (29/80). The proportions of patients whose course of disease was longer than 6 months, patients with disease in active phase, patients with visceral involvement, patients with adverse drug reactions, patients whose education level was lower than high school, unemployed patients, patients whose income was less than 50 thousand yuan / year and unmarried or divorced patients in the mental disorders group were significantly higher than those in the non-mental disorder group (P < 0.05).
Conclusion:
The risk of mental disorders is relatively higher in patients with SLE. The course of disease, disease activity, visceral involvement, adverse drug reactions, educational level, occupational status, economic income and marital status have significant effect on the occurrence of mental disorders in patients with SLE.
2018 Vol. 24 (2): 301-305 [
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64
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305
Clinical Study of Retcam Ⅲ in the Diagnosis of Neonatal Retinoblastoma by Retinal Imaging System
DAN Yanping, CHEN Qingran, RAO Li
DOI: 10.3969/j.issn.1006-6233.2018.02.034
Objective:
To analyze the clinical value of Retcam III in the early diagnosis of neonatal retinoblastoma using retinal imaging system.
Methods:
A retrospective analysis was carried out from July 2014 to July 2016 in 75 cases of RB newborns in our department of Ophthalmology and 100 cases of eyes. These patients were treated with binocular indirect ophthalmoscope, RetCam III and B type ultrasonic diagnosis RB.
Results:
100 eyes were diagnosed with a double eye ophthalmoscope for the gold standard to diagnose the AE phase of the eye condition, the use of RetCam III diagnosis in the A phase is consistent, B, C, D and E there was a small difference, but very close (P> 0.05). Through the analysis of the Kappa coefficient, the 2 kinds of RB staging are consistent, of which the Kappa coefficient was =0.9794, and the 95% confidence interval was 0.9598-0.9991. In 100 eyes, there were 58 eyes in the A-D period. Using binocular ophthalmoscope 132 standard tumor were detected by RetCam, III in the detection of tumor 130, the detection rate was 98.48%. 111 tumor bodies were detected by B type ultrasound, and the detection rate was 84.09% (P<0.05). RetCam III detection occurred in 2 cases of subconjunctival hemorrhage, the incidence rate was 2%, but there was no adverse reaction in corneal contusion, retinal hemorrhage and infection. The overall bad rate was 2%. The binocular ophthalmoscope and B ultrasonic in the above adverse complications were higher, no difference (P>0.05). This reveals that RetCam III is safe, reliable, and has good prognosis, and is worthy of clinical application.
Conclusion:
The early diagnosis of neonatal retinoblastoma by Retcam III (retina imaging system) can be used to diagnose the tumor staging and disease in a timely and accurate way. It has high specificity and detection rate, and has high diagnostic value in clinical.
2018 Vol. 24 (2): 305-309 [
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60
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309
Analysis of Urine Protein and High Risk Factors in Medical Examiners in Xinxiang
LI Yichun, et al
DOI: 10.3969/j.issn.1006-6233.2018.02.035
Objective:
To explore the detection of proteinuria in Xinxiang area and the influencing factors of high risk.
Methods:
A retrospective analysis was made on the physical examination data of 930 cases of physical examination in Xinxiang March 2015 to December 2016. According to the examination of urine protein group, urinary protein levels in normal subjects as control group, 759 cases of abnormal proteinuria as the observation group, 171 cases. The effects of the general information, weight mass index (BMI), medical history, blood lipid and other factors on the level of proteinuria were analyzed and compared.
Results:
The 930 cases included in the prevalence of proteinuria was 18.39%. The higher the age, the higher BMI index, the high frequency of heavy metal contact, the high blood pressure of blood lipid and blood sugar, the higher the rate of albuminuria. According to the P < 0.05 standard, the variables selected by single factor, such as age, BMI, occupation, blood pressure and other variables were evaluated. The level of proteinuria is abnormal for the dependent variables to establish regression model, Logistic regression analysis showed that age (OR=0.289), BMI (OR=0.094), occupation (OR=0.394), blood pressure (OR=0.353), blood lipids (OR=4.772), blood glucose (OR=0.230) in Xinxiang area is high risk persons influence the level of proteinuria abnormal factor.
Conclusion:
The prevalence of proteinuria in Xinxiang was higher examination, increased age, hypertension, high blood sugar, high blood lipids, high heavy metal contact occupation, the body mass index is high risk factors affecting proteinuria, can reduce the incidence of proteinuria by controlling the above factors.
2018 Vol. 24 (2): 309-313 [
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86
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313
Curative Effect of Folic Acid Combined with Vitamin B
12
in Treating Senile Coronary Heart Disease with Chronic Heart Failure and Homocysteinemia
ZHANG Zedan, ZENG Li, TAN Ping
DOI: 10.3969/j.issn.1006-6233.2018.02.036
Objective:
To investigate the efficacy of folic acid and vitamin B
12
in the treatment of elderly patients with chronic heart failure and hyperhomocysteinemia.
Methods:
A total of 80 elderly patients with CHD with hyperhomocysteinemia who were hospitalized from June 2015 to June 2017 were randomly divided into two groups. The patients in the control group were given symptomatic treatment while the patients in the experimental group Folic acid and vitamin B
12
were used to compare disease-related parameters, heart failure grade and quality of life in both groups.
Results:
The levels of HCY, NT-proBNP, TG, TC, LDL-C, MCP-1 and IL-8 in the experimental group were significantly lower than those in the control group (P <0.01). The NYHAⅠ ~ Ⅱlevel after treatment was significantly higher than that of the control group Group, there was a significant difference (P <0.05).
Conclusion:
The effect of folic acid combined with vitamin B
12
in the treatment of chronic heart failure and hyperhomocysteinemia in elderly patients with coronary heart disease is significant, and it is of reference significance.
2018 Vol. 24 (2): 313-317 [
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91
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317
Influence of Effect and Symptom Scores of Montelukast and Terbutaline in the treatment of Children Patients with Bronchial Asthma
YANG Shuo, HONG Yuan, DANG Yuanyuan
DOI: 10.3969/j.issn.1006-6233.2018.02.037
Objective:
To study influence of effect and symptom scores of montelukast and terbutaline in the treatment of children patients with bronchial asthma.
Methods:
124 children with bronchial asthma who were treated in our hospital from June 2014 to December 2016 were enrolled in this study. The children were divided into observation group and control group with 62 cases in each group, the two groups were given routine anti infection, oxygen inhalation, and relieving asthma and bronchiectasis and other related drugs. The control group was treated with terbutaline inhalation, while the observation group based on the control group of the drug, plus taking montelukast. After 2 months of treatment, the curative effect of the treatment group was compared with that of the two groups (FEV1, PEF and FEV1/FVC), symptom scores and adverse reactions.
Results:
The clinical control rate of the observation group was 40.32%, the total effective rate was 98.39%, which were significantly higher than the control group of 17.74% and 88.71%, the difference was statistically significant (P < 0.05). After treatment, the levels of FEV1, PEF and FEV1/FVC in the two groups were significantly higher than those before treatment, the observation group was significantly higher than the control group, the difference was statistically significant (P < 0.05). After treatment, the two groups were significantly lower than those in the control group in the day and night symptom scores, and the observation group was significantly lower than the control group, the difference was statistically significant (P < 0.05). The total incidence of adverse reactions in the observation group was 6.45%, compared with the control group of 11.29%, the difference was not statistically significant (P > 0.05).
Conclusion:
Montelukast and terbutaline in the treatment of children with bronchial asthma has a good effect, but also can effectively improve the symptom score.
2018 Vol. 24 (2): 317-321 [
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74
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Efficacy of Ray Bella in the Treatment of Chronic Atrophic Gastritis in Elderly Patients and its Effect on Serum Levels of Gastrin and Endothelin
PIAO Rennv, ZHAO Dong
DOI: 10.3969/j.issn.1006-6233.2018.02.038
Objective:
To study the effect of Ray Bella in the treatment of senile chronic atrophic gastritis and its influence on the serum levels of Gastrin and Endothelin.
Methods:
100 cases of elderly patients with chronic atrophic gastritis admitted in our hospital from July 2014 to July 2015 were selected and randomly divided into observe group and control group (50 cases in each group). Patients in the control group were given omeprazole (20mg/time,2time/day), levofloxacin (0.2 g/time,2 time/day), and furazolidone (100mg/time,3time/day). Patients in the observation group were given rabeprazole azole (20mg/time,1time/day), levofloxacin (0.2g/time,2 time/day), furazolidone (100mg/time,3 time/day). The treatments for patients in both groups were last two weeks. After treatment, the serum levels of gastrin and endothelin, the adverse reactions and the efficacy between treatments were compared.
Result:
After treatment, the GAS and ET levels in patients of the observation group were(176.38±13.29)ng/L, which higher than that in patients of the control group(142.27±12.32)ng/L; While, serum ET level(62.82±5.72)ng/L were lower than that in patients of the control group(78.39±6.59)ng/L. The differences of the two items were all statistically significant(P<0.05). The incidence rates of adverse reactions in observation group was 10.00%(5/50 cases), which less than that in the control group 38.00%(19/50 cases). The difference was statistically significant(P<0.05). The total effective rate of the observation group was 94.00%(47/50 cases), which higher than that in the control group 76.00%(38/50). The difference was statistically significant(P<0.05);
Conclusion:
Ray Bella has a significant effect in the treatment of chronic atrophic gastritis in elderly patients, which could significantly improve the level of serum gastrin, reduce the level of endothelin, and reduce the incidence of complications.
2018 Vol. 24 (2): 321-325 [
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110
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325
The Effect of Escitalopram on the Neurologic Function and Cognitive Function of the Post-stroke Depression Patients
HU Huiting, WANG Minzhong
DOI: 10.3969/j.issn.1006-6233.2018.02.039
Objective:
To explore the effect of Ai Sciplan on the neural function and cognitive function of patients with post-stroke depression.
Methods:
82 stroke patients were selected in our hospital from October 2016 to October 2017 were patients with depression as the research object, it was divided into study group ( 41 cases ) and control group ( 41 cases ) by random number table method , two groups of patients were treated with routine drug treatment the study group, patients taking escitalopram on the basis of routine therapy, patients in control group received placebo on the basis of conventional drug treatment, continuous treatment for 12 weeks. The depression of two groups were compared before and after treatment, nerve function, the cognitive function and life ability The evaluation.
Results:
Before treatment, there was no significant difference in the HAMD score, NIHSS score, MMSE score and FIM score between the two groups (P>0.05). After treatment, the HAMD scores, NIHSS scores, MMSE scores and FIM scores of the two groups were all improved, and the observation group was significantly better than the control group (P<0.05).
Conclusion:
In the clinical treatment of post-stroke depression, the use of escitalopram can improve neurological function and cognitive function, as well as improve depression and viability of patients.
2018 Vol. 24 (2): 325-328 [
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83
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Clinical Observation of Azithromycin in treating Mycoplasma Pneumoniae Infection in Children with Upper Respiratory Tract
CAI Qinwu, YANG Zijiang, WANG Changle
DOI: 10.3969/j.issn.1006-6233.2018.02.040
Objective:
To investigate the clinical effect of azithromycin in the treatment of Mycoplasma pneumoniae infection in children with upper respiratory tract.
Methods:
100 cases of upper respiratory tract mycoplasma pneumoniae infection in our hospital from October 2016 to July 2017 were randomly divided into two groups, azithromycin group receiving azithromycin and clarithromycin group receiving clarithromycin, The clinical indicators, the overall treatment effect, the related disease parameters and the adverse reactions of the two groups were compared.
Results:
The antipyretic time, the disappearance of cough, the disappearance of rales and the disappearance of wheeze in the azithromycin group were significantly lower than those in the clarithromycin group; the cure rate was significantly higher than that in the clarithromycin group; after treatment, the lymphocytes , IgA, IgE and IgG levels were significantly higher than the clarithromycin group, CRP and IL-4 levels were significantly lower than the clarithromycin group, there was a significant difference (P <0.01); two groups of children There was no significant difference in adverse reaction rate of all kinds of drugs (P> 0.05).
Conclusion:
azithromycin in children with upper respiratory tract infection Mycoplasma pneumoniae clinical effect is significant, higher safety, with reference.
2018 Vol. 24 (2): 328-332 [
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57
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Effect of Urapidil and Sodium Nitroprusside on Early Active Bleeding in Hypertensive Intracerebral Hemorrhage
CHEN Ruilian, CHEN Xindong, HUANG Yanzhen
DOI: 10.3969/j.issn.1006-6233.2018.02.041
Objective:
To investigate and compare the effect of urapidil and sodium nitroprusside on early active bleeding after hypertensive intracerebral hemorrhage.
Methods:
120 patients with hypertensive intracerebral hemorrhage admitted from January 2015 to June 2017 were randomly divided into two groups: urapidil and uracil sodium, sodium nitroprusside and sodium nitroprusside respectively Group hematoma volume, neurological score, disease-related parameters, long-term prognosis and adverse reactions.
Results:
The hematoma volume of the patients in the urapidil group was significantly lower than those in the sodium nitroprusside group at 1 week, 2 weeks and 4 weeks after treatment, and CSS scores were significantly higher than those in the sodium nitroprusside group. After treatment, the systolic blood pressure Viscosity, low cut-off viscosity, plasma viscosity, erythrocyte sedimentation rate and hematocrit were significantly lower than those in sodium nitroprusside group. MMSE score and FMA score were significantly higher than those in the three months after treatment There was a significant difference between sodium nitroprusside group and sodium nitroprusside group (P <0.05). There was no significant difference in ADR between the two groups during treatment (P> 0.05).
Conclusion:
Compared with sodium nitroprusside, urapidil has a more significant effect on early active bleeding in patients with hypertensive intracerebral hemorrhage.
2018 Vol. 24 (2): 332-336 [
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76
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Effect of the NBASS-APS on the Anxiety or Depression and Nursing Satisfaction caused by the Postoperative Pain in the Cataract Patient
ZHAO Ying, XU Lanfang, ZHAO Ya'nan, et al
DOI: 10.3969/j.issn.1006-6233.2018.02.043
Objective:
To evaluate the effectiveness of the nurse-based, with anesthesiologist andspecialist-supervised acute pain management model (NABSS-APS)on the postoperative pain, anxiety or depression, clinical prognosis and the nursing satisfaction in the cataract Patient.
Methods:
Totally 124 cataract patients were randomly divided into observation group (n=62) and control group (n=62). The observation group was given with the NABSS-APS while the control group was given traditional acute pain service. The postoperative pain was evaluated by the visual analog scale (VAS).The anxiety or depression emotions were assessed by the Self-rating Anxiety Scale (SAS) or Self-rating Depression Scale (SDS). The vision value and complication after the operation were tested to observe the clinical prognosis and the nursing satisfaction were tested by the questionnaire.
Results:
The pain of the observation group was significantly decreased when compared the control group (P<0.05) while the anxiety and depression of the observation group were significantly alleviated as compared with the control group (P<0.05). Besides, the vision value was improved as well as the complication was decreased in the observation group which were different with the control group (P<0.05). And the nursing satisfactions in the observation group were improved significantly between with the control group.
Conclusion:
The NBASS-APS could alleviate the postoperative pain and further to relieve the anxiety and depression symptom which reduce the complication, improve the clinical prognosis and nursing satisfaction.
2018 Vol. 24 (2): 339-343 [
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