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2018 Vol. 24, No. 1
Published: 2018-01-31
1
Protective Effect of Atorvastatin Preinduced HO-1 Expression on Acute Renal Injury Induced by Meglumine in Rats
WEI Kaiyong, et al
DOI: 10.3969/j.issn.1006-6233.2018.01.001
Objectives:
To investigate whether atorvastatin can induce heme oxygenase-l (HO-1) expression in rat kidneys to prevent contrast- induced acute kidney injury(CI-AKI) and its related mechanisms.
Methods:
48 healthy Sprague-Dawley male rats were randomly divided into the blank control group, model group , atorvastatin group and zinc protoporphyrin IX(ZnPPIX) group. A rat model of CI-AKI was established by intramuscular injection of gentamicin sulfate for 2 days and then intravascular injection of 76% meglumine diatrizoate. Atorvastatin group and ZnPPIX group were pretreated with atorvastatin/ZnPPIX before using meglumine diatrizoate. We detected changes in serum creatinine (Scr) before and after model establishment, measured the interleukin-6(IL-6), monocyte chemotactic protein 1 (MCP-1),malondialdehyde(MDA) and total antioxidant capacity (T- AOC) as well as the protein expression of HO-1, Bax, Bcl-2 in the renal tissue, and analyzed the renal cell apoptosis index(AI).
Results:
After contrast agent injection, compared with the control group,the SCr of the other three groups were significantly increased and reached the CI-AKI standard, Meanwhile, the inflammatory and oxidative stress markers and AI were also significantly increased. Compared with the model group, in atorvastatin group, the expression of HO-1 protein in renal tissue increased significantly, while the level of inflammation and oxidative stress and both AI and SCr decreased significantly (P＜0.05),in ZnPPIX group, the expression of HO-1 protein in renal tissue also increased, but the level of inflammation and oxidative stress and both AI and SCr increased significantly(P＜0.05).
Conclusion:
Atorvastatin can induce expression of HO-1 protein in rat kidney throuh which inhibit the renal inflammation and oxidative stress and cell apoptosis, thereby protecting against CI-AKI.
2018 Vol. 24 (1): 1-5 [
Abstract
] (
75
)
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6
Clinical Value of Serum Cholinesterase in Evaluating Liver Injury Induced by Antituberculosis Therapy in Patients with HBV Infection and Pulmonary Tuberculosis
LIN Tao
DOI: 10.3969/j.issn.1006-6233.2018.01.002
Objective:
To analyze the clinical value of serum cholinesterase (CHE) in evaluating liver injury induced by antituberculosis therapy in patients with hepatitis B virus (HBV) infection and pulmonary tuberculosis.
Methods:
112 cases of patients with HBV infection and pulmonary tuberculosis (combined group), 94 cases of patients with simple pulmonary tuberculosis (simple group) and 102 healthy subjects (healthy group) were enrolled in the study. All patients with pulmonary tuberculosis received antituberculosis treatment. Serum CHE levels and liver function indexes were detected, and the correlation between CHE and liver function indexes was analyzed.
Results:
During the treatment, the normal rate of liver function, the mild injury rate and the severe injury rate in the combined group were 16.07%, 44.64% and 39.29%, respectively while those in the simple group was 21.28%, 61.70% and 17.02%, respectively (P<0.05).The serum CHE level ranged from high to low were the combined group, the simple group and the healthy group, and the difference was statistically significant (P<0.05), and the more serious liver injury, the lower serum CHE level (P<0.05). After treatment, the levels of HBV-DNA quantification, total bilirubin(TBIL), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of the combined group were significantly increased (P<0.05), while CHE level was significantly decreased (P<0.05). Serum CHE was negatively correlated with TBIL, ALT and AST (r=-0.712, 0.723,0687, P<0.05). The ROC curve results of liver injury induced by anti tuberculosis treatment and analyzed by serum CHE showed that the area under the curve was 0.912 (P<0.05) and the diagnostic critical value was 4325.54U/L, and the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of serum CHE diagnosis were 91.49%, 83.33%, 96.63%, 65.22% and 90.18% with high diagnostic efficiency.
Conclusion:
Serum CHE can well reflect the degree of liver injury and high diagnostic efficiency in patients with HBV infection and pulmonary tuberculosis during antituberculosis treatment, which provides references for early antiviral therapy.
2018 Vol. 24 (1): 6-10 [
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72
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11
Influence of KW-2478 on the Proliferation of Tumor Cells
CHANG Xiaomin, WANG Jianping, ZHAO Xuerong, et al
DOI: 10.3969/j.issn.1006-6233.2018.01.003
Objective:
To study the effect on proliferation of KW-2478 to Eca109 and KYSE-150 esophageal cancer cell line, SGC-7901 gastric cancer cell line, HepG2 hepatoma cell line and MCF-7 breast cancer cell in vitro. And to observe the effect of KW-2478 to HL-7702 normal hepatocytes.
Methods:
HL-7702, Eca109, KYSE-150, SGC-7901, MCF-7 and HepG2 cell lines were cultured in vitro, give different concentrations of KW-2478, MTT assay test cell proliferation after 24h and 48h.
Results:
After 24h and 48h different concentrations of KW-2478 to the tumor cells, the proliferation of five tumor cells were reduced in dose-dependent and time-dependent, and showed dose and time interaction on Eca109 cells and HepG2 cells, but HL-7702 was not significantly affected.
Conclusion:
KW-2478 have inhibitory effect to Eca109, KYSE-150, SGC-7901, MCF-7 and HepG2 cells, and had no significant effect on the proliferation of HL-7702 normal hepatocytes.
2018 Vol. 24 (1): 11-16 [
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53
)
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16
Comparison of Risk of Hypotension between Cesarean Section in Pregnant Women with Severe Preeclampsia and Healthy Pregnant Women under Combined Spinal-epidural Anesthesia
SHI Jingjing, DONG He
DOI: 10.3969/j.issn.1006-6233.2018.01.004
Objective:
To investigate the risk of hypotension in cesarean section of pregnant women with severe preeclampsia and healthy pregnant women under combined spinal epidural anesthesia.
Methods:
40 pregnant women with severe preeclampsia were enrolled from August 2016 to August 2017 as pregnant women with severe preeclampsia and 240 healthy pregnant women were enrolled as healthy maternal groups. The maternal anesthesia period was compared between the two groups , Neonatal weight, hypotension incidence, anesthesia SBP, DBP, MAP, HR and other adverse reactions.
Results:
The dosage of lidocaine, the total amount of infusion, the dose of ephedrine and the weight of neonatal were lower than those of healthy pregnant women, and the incidence of hypotension was significantly higher than that of healthy pregnant women group. SBP, DBP and MAP The baseline values, the lowest values after anesthesia, the lowest blood pressure drop and the basal value - the lowest blood pressure values were significantly higher than those in the healthy pregnant women group; HR basal value, lowest postnesthesia, lowest heart rate decline, basal value - lowest heart rate (P <0.01). The significant difference between the two groups was higher than that of the healthy pregnant women group, and the highest heart rate was higher than that of the healthy pregnant women group (P <0.01). The postoperative pain rate was significantly higher than that of healthy pregnant women group (P <0.05).
Conclusion:
Pregnant women with severe preeclampsia have a higher risk of developing low blood pressure during cesarean section under combined spinal epidural anesthesia. Therefore, it is necessary to adjust the anesthetic dose and strengthen the management of intraoperative infusion.
2018 Vol. 24 (1): 16-20 [
Abstract
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61
)
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20
Effects of Remifentanil Combined Anesthesia on IL-6 MDA and SOD Levels in Patients with Open Colon Cancer Surgery
JI Peng, YAO Fan, CAO Bo, et al
DOI: 10.3969/j.issn.1006-6233.2018.01.005
Objective:
To investigate the effect of remifentanil combined anesthesia on the levels of interleukin-6 (IL-6), malondialdehyde (MDA) and superoxide dismutase (SOD) in postoperative patients undergoing open colon cancer surgery.
Methods:
From March 2015 to March 2017 in our hospital, 68 cases of open colorectal cancer patients with operation were selected as the research object. According to the random number table method the patients were divided into two groups. The study group underwent remifentanil and propofol anesthesia, the control group underwent sufentanil and propofol anesthesia. The levels of IL-6, IL-8, CRP, MDA, SOD and adverse reaction rates of the two groups before and after anesthesia induction, 1h after operation, 1D after operation and 3D after operation were compared.
Results:
There was no significant difference in the levels of IL-6, IL-8, CRP, MDA and SOD in the two groups before induction (P>0.05). After operation, the levels of IL-6, IL-8 and CRP in the two groups were significantly higher than those before the operation (P<0.05). One hour, oneday and three days after operation, The levels of IL-6, IL-8 and CRP in the study group were significantly lower than those in control group (P<0.05). MDA was increased and SOD decreased in both group (P<0.05). Compared between groups, there was no statistical difference in postoperative of one hour and one day (P>0.05). The MDA level of 3D after operation was lower than that of control group, while SOD level was higher than that of control group (P<0.05). There was no significant difference in the rate of adverse reaction between the two groups (χ
2
=0.327, P>0.05).
Conclusion:
Remifentanil combined anesthesia applied to open colon cancer surgery can significantly reduce the levels of IL-6, IL-8, CRP, MDA, and increase the level of SOD, which significantly reduce the postoperative inflammatory and oxidative stress response.
2018 Vol. 24 (1): 20-26 [
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90
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26
The Expression of HGF and its Receptor c-met in Human Esophageal Carcinomaand the Relationship to Lymphangiogenesis and Lymphatic Metastasis of EC
ZHAO Yang, LIU Shasha, et al
DOI: 10.3969/j.issn.1006-6233.2018.01.006
Objective:
To determin the expression of HGF and its receptor c-met in human esophageal carcinoma and to investigate the relationship between HGF and its receptor with lymphangiogenesis and lymphatic metastasis of EC.
Method:
Immunohistochemical staining was used to examine expression of HGF and c-met in 30 cases of NM and 70 cases of EC tissues.The microlymphatic density (LMVD) in esophageal carcinoma was calculated by D2-40 as the specific marker of lymphatic endothelium.
Results:
Expression of HGF and c-met in EC showed significantly higher than that in NM, and they were positively correlated with lymphangiogenesis and lymphatic metastasis of EC.
Conclusion:
The overexpression of HGF and c-met may play an important role in lymphangiogenesis and lymphatic metastasis of EC.
2018 Vol. 24 (1): 26-30 [
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67
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30
The Relationship between CT Manifestations and Immunohistochemical Typing of Gastrointestinal Stromal Tumors
CHANG Ying, WANG Dongmei, MAI Xiaoli
DOI: 10.3969/j.issn.1006-6233.2018.01.007
Objective:
To study the CT applied value in the diagnosis of gastrointestinal stromal tumor, and observe its performance and the relationship with immunohistochemical, so as to provide reference for staging for clinical diagnosis and treatment plan.
Methods:
80 cases of gastrointestinal stromal tumors confirmed by operation and pathology in our hospital from April 2014 to April 2017 were selected as the research objects, including 48 cases of gastric lesions, 23 cases of small intestinal lesions, 7 cases of abdominal lesions, 1 case of esophageal lesions, 1 case of retroperitoneal lesions. All patients underwent CT scan. The location, size, shape, border, growth pattern, necrosis degree and calcification of the tumor were statistically analyzed, and compared with immunohistochemical typing.
Results:
In 80 patients, there were 24 cases, 19 cases, 9 cases and 28 cases of smooth muscle differentiation, nerve orientation differentiation, smooth muscle and nerve bidirectional differentiation and lack of differentiation. Eighty patients had 85 gastrointestinal stromal tumors, of which 40 were diameter less than 5cm, and 31 lesions were 5 ~ 10cm in diameter. The diameter of 14 lesions was more than 10cm. The contour of 52 lesions was fairly regular, and 33 lesions were irregular or lobule. The boundaries of 72 lesions were clear and 13 lesions were not clearly defined by the adhesion or infiltration of the surrounding area. 55 lesions were exogenous, 20 lesions were cross-wall growth, and 10 lesions were endogenous. There was no obvious necrosis in 40 lesions, 27 lesions were focal necrosis, and 18 lesions had extensive necrosis. Smooth muscle mass direction differentiation group > 10cm in diameter, mass increase, the mass proportion of extensive necrosis was obviously higher than that of neural differentiation of direction group, the smooth muscle and nerve two-way characteristics, lack of differentiation groups (P<0.05).
Conclusion:
CT examination is a clinical diagnosis of gastrointestinal stromal tumor is an effective way, to the CT manifestation of gastrointestinal stromal tumor give careful observation to determine tumor immune group tumble type, it is of great use value and significance, can further promote the use.
2018 Vol. 24 (1): 30-34 [
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68
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34
The Level Changes and Significance of Serum VH HIF-1α and HIF-2α Levels in Patients with Kidney Cancer
SHI Chunxia, LI Zhongxin, LIU Yongquan, et al
DOI: 10.3969/j.issn.1006-6233.2018.01.008
Objective:
To research the changes and significance of serum von hippel-lindau (VHL), hypoxia-inducible factor (HIF)-1α and HIF-2α in patients with renal cancer.
Method:
45 cases of renal carcinoma were collected from January 2015 to April 2016 as the renal cell cancer group, and at the same time the collection of healthy persons as control group, serum VHL, HIF-1α and HIF-2α level of two groups were examined; The maximum diameter of renal cancer patients was measured; Patients with renal cell carcinoma were followed up for 6 months, observed and recorded the recurrence patients.
Results:
The level of serum VHL in renal cancer group decreased significantly compared with that in control group, while levels of HIF-1α and HIF-2α were obviously higher( P<0.01) . Expression of serum VHL, HIF-1α and HIF-2α was not related to age and sex in renal carcinoma (P>0. 05) ,while there was significantly correlated with pathological grade, clinical stages, diameter of cancer site and lym-phatic metastasis (P<0.01). Level of serum VHL in recurrent cases was obviously lower, while levels of HIF-1α and HIF-2α were obviously higher than non-recurrent cases( P< 0.05,P<0.01) .
Conclusion:
Levels of serum VHL, HIF-1α and HIF-2α are correlated significantly with pathological grade, clinical stages, size of carcinoma and lymphatic metastasis, which indicates indexes mentioned above could be play an important role in the occurrence and development of clear cell renal carcinoma.
2018 Vol. 24 (1): 34-38 [
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94
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38
Effects of Dexmedetomidine Combined with Propofol on Liver and Kidney Function and Blood Gas Analysis in Patients with Brain Injury
CAO Guizhen, YIN Le, CHEN Jianjun
DOI: 10.3969/j.issn.1006-6233.2018.01.009
Objective:
To study the effects of dexmedetomidine and propofol in patients with liver and kidney function, blood gas analysis of craniocerebral injury.
Methods:
80 cases of craniocerebral injury admitted in our hospital from November 2012 to November 2017 (40 cases of normal liver and kidney function, 40 cases of abnormal liver and kidney function) were retrospectively studied. According to the random number table method, 40 cases of patients with normal liver function were divided into group A and group B, each of 20 cases; 40 cases of liver and kidney dysfunction were divided into group C and group D, each of 20 cases. Group A and group C were anesthetized with dexmedetomidine combined with propofol, and group B and D were used to induce anesthesia by propofol alone. The general data of all patients (gender, age, BMI, ASA score, and operation time) were counted; The liver function (AST, ALT), renal function (serum creatinine, blood urea nitrogen) and blood gas analysis (PaO
2
and PaCO
2
) were detected before operation (T
1
), 12h (T
2
) after operation and 24h (T
3
) after operation.
Results:
There was no significant changes of AST and ALT in 12h and 24h after operation (P > 0.05). There was no significant difference in AST and ALT between group A and group B, group C and group D at the same time point (P > 0.05). 12h and 24h after operation, the BUN and Scr were significantly increased (P < 0.05). The blood urea nitrogen and serum creatinine levels in the group A were significantly lower than those in the group B (P < 0.05), and the group C was significantly lower than that in the group D (P < 0.05). After operation, all the patients in each group decreased significantly (P < 0.05) and PaCO
2
significantly increased (P < 0.05). At the same time point, the PaO
2
value of group A was higher than that of group B (P < 0.05), and the C group was significantly higher than that of group D (P < 0.05), PaCO
2
value in group A was significantly lower than that of group B (P < 0.05).
Conclusion:
Dexmedetomidine combined with propofol can improve renal function and blood gas analysis in patients with craniocerebral injury, but has no obvious protective effect on liver and little effect on liver function.
2018 Vol. 24 (1): 38-43 [
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89
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43
Clinical analysis of Pulmonary Consolidation in Children with Mycoplasma Pneumoniae Infection
LU Sukun, LIU Jianhua, SHUAI Jinfeng, et al
DOI: 10.3969/j.issn.1006-6233.2018.01.010
Objective:
To investigate the clinical diagnosis and treatment of childhood mycoplasma pneumoniae infections with lung consolidation.
Methods:
Clinical data and treatment of 149 children mycoplasma pneumoniae infections with lung consolidation hospitalized were analyzed retrospectively.
Results:
(1) All the 149 patients had fever and cough. The average course of disease before admission was 10.7±6.0 days. The average course of disease after admission was 3.87±4.57 days and the average stay was 15.9±6.5 days. Among the 149 children, there were 105 cases with hyperpyrexia; White blood cell (WBC) was normal in 87 cases; Unilateral lung involvement was found in 131 cases; there were 70 cases with Pleural effusion and 5 cases with pulmonary necrosis; And there were 58 preschool children and 75 school-age children, no significant difference was found in sex, maximum body temperature, length of stay, fever duration and complications between the two groups. (2) For the treatment, azithromycin was the first drug and sensitive antibiotics was used if complicated with bacterial infection. And bronchoalveolar Lavage with bronchoscope was indispensable. Moreover, short-period application of glucocorticosteroid on critical patients can effectively improve clinical symptoms.
Conclusions:
Childhood mycoplasma pneumoniae infections with lung consolidation can occur at all ages and more common at preschool and school age. Its incidence of RMPP is high. White blood cell was normal and Unilateral lung involvement was found in most patients. It was relatively serious and had prolonged course,however,it can be clinically cured with combined modality treatment mostly.
2018 Vol. 24 (1): 43-46 [
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76
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47
Effect of Additional Use of Pidotimod Therapy on Levels of Serum Inflammatory Factors and Immune Function in Children with Tonsillitis
WU Yunfei
DOI: 10.3969/j.issn.1006-6233.2018.01.011
Objective:
To investigate the effect of additional use of pidotimod therapy on levels of serum inflammatory factors and immune function in children with tonsillitis.
Methods:
240 cases of children with tonsillitis admitted in our hospital from January 2015 to August 2016 were enrolled in the study, and they were divided into control group (treated with routine drugs, n=140) and observation group (additionally treated with pidotimod therapy, n=100) by the random number table method. The serum inflammatory factors [interleukin -4 (IL-4), interleukin -6 (IL-6), interferon γ (IFN- γ)], the immune function [T cell subsets (CD3+, CD4+, CD8+)], the relief of clinical symptoms (duration of fever, duration of cough, duration of tonsil inflammation), recurrent frequency after 1 year of treatment and readmission rates in the two groups were observed before and after treatment.
Results:
There were no significant differences in IL-4, IL-6, IFN-γ, CD3+, CD4+ and CD8+, duration of fever, duration of cough and duration of tonsil inflammation between the two groups before treatment (P > 0.05). After treatment, IL-4, IL-6 and CD8+ in the two groups were significantly decreased, IFN-γ, CD3+ and CD4+ were significantly increased, the duration of fever, duration of cough and duration of tonsil inflammation were significantly shortened, and the changes of the above indexes (except CD4+) were more obvious in the observation group than the control group (P < 0.05). After 1 year of treatment, the recurrent frequency and readmission rate of the observation group were significantly less or lower than those of the control group (P < 0.05).
Conclusion:
The additional use of pidotimod therapy is effective in the treatment of children with tonsillitis. It can relieve the clinical symptoms and improve the prognosis of children through effective regulation of serum inflammatory factors and immune function.
2018 Vol. 24 (1): 47-50 [
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84
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50
The Clinical Research of Arotinolol for Treatment of Patients with Hypertension Associated with Anxiety and Depression
YANG Yang, LIU Yancheng, WANG Jing
DOI: 10.3969/j.issn.1006-6233.2018.01.012
Objective:
To investigate the clinical efficacy of Arotinolol treatment of patients with hypertension associated with anxiety and depression.
Methods:
67 cases of patients with 1-2 stage hypertension associated with anxiety and depression disorder being evaluated by SAS and SDS from Chengde Central Hospital Hypertension clinic were divided into experimental group and control group from February 2016 to April 2017. The control group were treated with Enalapril 10mg once a day and the experimental group were treated with Arotinolol 10mg once a day for 4 weeks. Two groups were evaluated with Depression Rating Scale (SAS) and Self-Rating Anxiety Scale (SDS) and the blood pressure were measured before and after treatment.
Results:
The effects of hypertension in two groups showed significant difference (P < 0.01) than those before treatment. There was no significant difference in the level of blood pressure drops between the two groups (p> 0.05). The score of SAS and SDS were lower (P<0.01) in the experimental group showed significant difference (P<0.01) compared with the control group. The heart rate of the experimental group decreased significantly after treatment compared with that of the control group (p<0.01).
Conclusion:
Arotinolol can effectively reduce the blood pressure and score of Depression Rating Scale (SAS) and Self-Rating Anxiety Scale (SDS)。
2018 Vol. 24 (1): 50-54 [
Abstract
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135
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55
Comparison of PFNA Internal Fixation and Arthroplasty in the Treatment of Unstable Intervertebral Fractures in Elderly Patients
LI Kun, ZHANG Yumin, GUO Jianbin, et al
DOI: 10.3969/j.issn.1006-6233.2018.01.013
Objective:
To investigate and compare the efficacy of PFNA internal fixation and arthroplasty in treatment of unstable intertrochanteric fractures in elderly patients.
Methods:
A total of 150 patients with unstable intertrochanteric fractures admitted from October 2013 to October 2016 were randomly divided into two groups. The patients in the internal fixation group received PFNA internal fixation. The patients in the joint replacement group were treated with arthroplasty. Perioperative clinical indexes, complications, recovery of joint function and long-term quality of life of the two groups before and after treatment.
Results:
The operation time, intraoperative blood loss, postoperative drainage, postoperative weight-bearing time and fracture healing time were significantly lower in the patients in the internal fixation group than those in the joint replacement group. The quality of life scores in each dimension were significantly different There was significant difference between the two groups (P <0.01). The overall complication rate was significantly lower than that of the control group. The rate of joint function was significantly higher than that of the joint replacement group (P <0.05).
Conclusion:
Compared with the arthroplasty, the clinical efficacy of PFNA internal fixation in patients with unstable intertrochanteric fractures is more significant and has reference value.
2018 Vol. 24 (1): 55-58 [
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69
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59
Clinical Analysis of 50 Cases of Cholelithiasis Treated by Laparoscopic Choledocholithotomy with Nephroscope
HUANG Jintuan, CHEN Yexi
DOI: 10.3969/j.issn.1006-6233.2018.01.014
Objective:
To evaluate the clinical efficacy of laparoscopic cholecystectomy combined with laparoscopic choledocholithotomy using a rigid nephroscope in the treatment of 50 cases of cholelithiasis.
Methods:
A total of 100 patients with cholelithiasis admitted to the department of General Surgery of the Third People's Hospital of Hui Zhou were divided into observation group and control group according to random number table. Patients in observation group were treated with laparoscopic cholecystectomy plus laparoscopic choledocholithotomy performed using a rigid nephroscope, while those in control group were treated with traditional open operation. The total effective rate, operation duration, length of stay, time of postoperative anal exhaust, postoperative drainage tube indwelling time, intraoperative bleeding, incident rates of postoperative complications, and the recurrence rate between the two groups were compared.
Results:
The total effective rate of clinical efficacy in the observation group was significantly higher than that in the control group (96.00%). The operation duration, length of stay, time of postoperative anal exhaust, and postoperative drainage tube indwelling time of the observation group were significantly shorter than those in control group (P<0.05). The intraoperative bleeding was significantly less in the observation group (P <0.05). There was no significant difference in the recurrence rate of stones between the two groups (P> 0.05), while the incident rates of postoperative complications were significantly lower in the observation group (2.00%), the difference was statistically significant (P<0.05).
Conclusion:
Laparoscopic cholecystectomy combined with laparoscopic choledocholithotomy using a rigid nephroscope has higher effective rate, lower incident rates of postoperative complications, and causes less damage in the treatment of cholelithiasis, which are beneficial to the recovery of patients and makes it worth generalizing.
2018 Vol. 24 (1): 59-62 [
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70
)
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62
The Effect of Different Frequencies of rTMS on the Improvement of Cerebral Infarction and Depression and the Change of FTHUE-HK Rating
PING Ping, BA Chunhe, ZHANG hongxia, et al
DOI: 10.3969/j.issn.1006-6233.2018.01.015
Objective:
To investigate the effect of repeated transcranial stimulation (rTMS) on the improvement of depression in patients with cerebral infarction and the change of FTHUE-HK (FTHUE-HK) rating in patients with hemiplegia.
Methods:
96 patients with cerebral infarction who were treated in our hospital from September 2015 to August 2016 were selected and divided into three groups: 0.5Hz group, 1Hz group and 2Hz group , Each group of 32 cases. Three groups were using the basic drug therapy and rehabilitation training, on the basis of this group with the corresponding frequency rTMS for treatment. The improvement of depression in the three groups before and after treatment was evaluated by the Depression Self-Rating Scale (SDS). The changes of FTHUE-HK were observed before and after treatment.
Results:
There was no significant difference in SDS scores between the two groups before treatment (P> 0.05). However, after treatment, the scores of SDS in the three groups were significantly decreased, but the 0.5Hz group and the 2Hz group all dropped below the cut- (P <0.05), but there was no significant difference between the two groups (P <0.05), but there was no significant difference between the two groups (P <0.05). There was no significant difference in FTHUE-HK between the two groups before treatment, and there was no significant difference between the two groups and the 2Hz group (P <0.05).
Conclusion:
The use of different frequencies of rTMS in the treatment of cerebral infarction patients can improve the patient's depressive symptoms and hemiplegia upper limb function, but in contrast, high frequency and low frequency rTMS treatment of cerebral infarction is more significant.
2018 Vol. 24 (1): 62-65 [
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85
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65
Effect of Thoracoscopic Two-hole Method on Pulmonary Bulla Resection and the Effect of VAS Score
HAO Yanhong, XI Junfeng, LI Wanning
DOI: 10.3969/j.issn.1006-6233.2018.01.016
Objective:
To explore the video-assisted thoracoscopic surgery (video-assisted thoracic, surgery, VATS) under the influence of the two hole type spell bullae of lung resection and VAS score efficacy.
Methods:
From May 2014 to May 2016, 98 patients with bullous pulmonary bullae were operated under VATS. Under the advice of the physician, the patients were voluntarily divided into the observation group (49 cases) and the control group (49 cases). The patients in the observation group were excised by two - hole method, and the traditional traditional three - hole resection was performed in the control group. The perioperative time, intraoperative blood loss, incision length, extubation time and hospitalization time, pulmonary function, VAS score and VRS score, postoperative complications, recurrence of one year and incidence of one year pneumothorax in two groups were compared.
Results:
There was no statistical difference in operative time and intraoperative blood loss between the two groups. The length of incision, extubation time and hospitalization time in the observation group were significantly less than those in the control group. The difference of lung function between the two groups before and after treatment was not statistically significant. Before treatment, there was no significant difference in the VAS score and VRS score between the two groups. After treatment, the VAS score and VRS score of the two groups decreased significantly, and the decrease in the observation group was significantly better than that in the control group (P < 0.05). There was no significant difference in the incidence of complications, one year recurrence and the incidence of one year pneumothorax in the two groups ( P > 0.05).
Conclusion:
The two hole method and three type of spell bullae of lung resection in patients with symptoms under VATS are alleviated effectively the safety, and the two hole spell has less pain, less trauma, postoperative recovery and good characteristics such as fast, and it is worthy of reference.
2018 Vol. 24 (1): 65-69 [
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79
)
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Quantitative Evaluation of the Degree of Consciousness Disorder in Coma patients and the Value of Prognostic Evaluation by Narcotrend Index
ZHAONG Yingyu, CHEN Yuchong, PAN Tingjun, et al
DOI: 10.3969/j.issn.1006-6233.2018.01.017
Objective:
To explore the quantitative assessment and prognostic value of the Narcotrend index for the degree of disturbance of consciousness in coma patients.
Methods:
42 severe comatose patients admitted to our department of critical care medicine from January 2016 to February 2017 were selected. The correlation between NT and APACHE II and GCS score before and after stimulation, the correlation between NT and GOS score before and after stimulation, and prognosis of NT before and after stimulation were analyzed.
Results:
The NT value of the patients was (56.62 ± 25.59), GCS was (4.55 ± 0.80), APACHE II was (28.57 ± 7.46), and there was a positive correlation between NT and GCS before stimulation (correlation coefficient r = 0.881, P <0.001). The NT value of the patients was (61.72 ± 29.87), the GOS was (2.43 ± 1.35), and the NT and GOS scores before and after stimulation were significantly correlated with APACHE II (correlation coefficient r=0.-952, P <0.001, r=0.905, P<0.001).The area under the curve of NT before stimulation was 0.916, 95% confidence interval was 0.833~ 0.999, and coma patients were predicted The optimal cut-off rate was 59.67, the sensitivity was 92.9%, the specificity was 71.4%, the missed diagnosis rate was 7.1%, the misdiagnosis rate was 28.6%, and the area under the curve of NT value after stimulation was 0.957, 95% The optimal cut-off rate was 74.58, the sensitivity was 97.3%, the specificity was 92.9%, the misdiagnosis rate was 2.7%, the misdiagnosis rate was 7.1%, and the NT value of the patients before and after stimulation was 74.58. The area under the good prognosis curve of the coma patients was 0.916, 0.957> 0.9, the NT value predicted the good prognosis of coma patients Correctness higher.
Conclusion:
The Narcotrend index of coma patients is significantly correlated with GCS and APACHE II scores, and it can be used to evaluate the prognosis of coma patients. In particular, the NT value of coma patients is better than that before stimulation. The prognosis, sensitivity, specificity are improved, missed diagnosis rate and misdiagnosis rate decreased.
2018 Vol. 24 (1): 69-73 [
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75
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73
The study and clinical significance of contrast medium injection way of direct inferior vena cava CTV by multi-slice CT
CAO Hongwei, XING Yuanyuan, CHOU Hengzhi, et al
DOI: 10.3969/j.issn.1006-6233.2018.01.018
Objective:
By comparing the image quality of the inferior vena cava (IVC) direct CT venography (CTV) using multi-slice computed tomography (MSCT), under different contrast medium injection concentrations,delay scan times conditions, to obtain optimal contrast medium injection way.
Methods:
Using 64-detector row scanner (Sensation 64; Siemens), 56 patients who were suspected of inferior vena cava diseases underwent IVC direct CTV examination, Randomly divided into 8 groups. At the same conditions of contrast medium rate(3.5~4.0mL/s), liquid volume (unilateral liquid volume 200mL), delay scan time (30s), the contrast medium concentrations of each group were 1:2、1:4、1:6、1:9, compare the image quality of the four groups. At the same conditions of contrast medium rate(3.5~4.0mL/s), contrast medium concentrations(1:4~1:6), liquid volume (unilateral liquid volume 200mL), dual phase scan, the firs phase delayed scan time of the four experimental groups were 20s、25s、30s、35s respectively, after 20s scan repeatedly. Collecting 25s、30s、35s、40s、45s imaging data, then compare the image quality.
Result:
The image quality of the four contrast medium concentration groups are not all the same (H＝19.727, P<0.001),1:4~1:6 groups is better than others;The image quality of delay scan times is not all the same (H＝22.262, P<0.001), 30s~40s phases is the best.
Conclusion:
IVC direct CTV using MSCT is feasible, at the same conditions of contrast medium rate (3.5~4.0mL/s), liquid volume (unilateral liquid volume 200mL), the best concentration is 1:4~1:6, the best delay scan time is 30s~40s.It can obtain better image quality and be used to diagnose the IVC diseases.
2018 Vol. 24 (1): 73-77 [
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505
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77
The Clinical Effects of Single-aperture Thoracoscopic and Mediastinal Lymph Node Cleaning were Analyzed
ZHAO Yong, SUN Zhenyu, GU Minwei, et al
DOI: 10.3969/j.issn.1006-6233.2018.01.019
Objective:
To analyze the clinical efficacy of single-aperture thoracoscopic pulmonary lobes and mediastinal lymph node cleaning.
Methods:
102 cases of lung cancer patients admitted in our hospital from January 2015 to January 2017 were selected. The patients in routine group were taken the three hole method of thoracoscopic surgery and systemic lymph node dissection, and patients in the experimental group were taken the single hole thoracoscopic lobectomy and systematic lymph node dissection.
Results:
The time of operation, the amount of intraoperative bleeding, the time of hospitalization, and the cost of medical treatment were lower in the experimental group than in the routine group. There was no significant difference between the two groups of drainage tube placement time and total flow rate (P>0.05). The VAS score of the patients in the experimental group was significantly lower than that in the routine group (P<0.05).
Conclusions:
Taking the single hole thoracoscopic lobectomy and systematic lymph node dissection for patients with lung cancer has significant clinical curative effect.
2018 Vol. 24 (1): 77-80 [
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79
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80
The Expression and the Clinical Significance of CDC25A and CDK1 in Gastric Cancer
FU Hua, YU Aijun, CHEN Kai, et al
DOI: 10.3969/j.issn.1006-6233.2018.01.020
Objective:
To investigate the expression and the clinical significance of CDC25A and CDK1 in gastric carcinoma.
Methods:
Immunohistochemistry was used to detect the expression of CDC25A and CDK1 in gastric cancer tissue of 119 cases. The correlation of the expression CDC25A and CDK1 and clinical pathological characteristics were analyzed.
Results:
The expression of CDC25A and CDK1 in highly differentiated gastric cancer tissues was highly expressed in low differentiated gastric cancer tissues, and had significant correlation with the pathological grade of gastric cancer (P<0.001). CDC25A and CDK1 were low expression in early gastric cancer, high expression in advanced gastric cancer tissue and significant correlation with TNM staging of gastric cancer (P<0.01). The expression of CDC25A and CDK1 is significantly associated with lymph node metastasis (P<0.001) in patients with gastric cancer. CDC25A and CDK1 are highly expressed in gastric carcinoma with lymph node metastasis, and low expression in gastric cancer tissues without lymph node metastasis (P<0.001).
Conclusion:
CDC25 and CDK1 could be potential biomarker for diagnosis and treatment of gastric cancer.
2018 Vol. 24 (1): 80-83 [
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50
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87
Application of New Biological Patch in Female Pelvic Floor Dysfunction
JIN Li, HONG Li
DOI: 10.3969/j.issn.1006-6233.2018.01.022
Objective:
To explore the effect of new biological patch in female pelvic floor dysfunction.
Methods:
140 patients with pelvic floor dysfunction were enrolled in this study from January 2013 to April 2016. The patients in the control group were treated with modified vaginal repair. The patients in the observation group were treated with biologic patch, The clinical indexes, complication rate, pelvic floor function index, quality of life and overall treatment effect were compared between the two groups.
Results:
The operation time, intraoperative blood loss, hospitalization time and residual urine volume were significantly lower in the observation group than in the control group. Compared with the control group, the resting state of the resting state was significantly lower than that of the control group The maximal contractility, sustained contractility, coordination ability and maximum urinary flow rate were significantly higher than those in the control group. PFIQ-7 score, PISQ-12 score and ICI-Q-SF score group were significantly lower at 6 months after treatment (P <0.01). The overall complication rate was significantly lower than that of the control group (P <0.01). The total effective rate was significantly higher than that of the control group (P <0.01), and the difference was significant (P <0.05).
Conclusion:
The new biological patch in female pelvic floor dysfunction in the application of the effect is significant, with reference.
2018 Vol. 24 (1): 87-90 [
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70
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Changes of Rennin Angiotensin Aldosterone in Acute Myocardial Infarction in Different Parts
LI Shucheng, WANG Hong, LIU Chao, et al
DOI: 10.3969/j.issn.1006-6233.2018.01.023
Objective:
To observe the changes of renin, angiotensin II (ATII) and aldosterone (ALD) in plasma of patients with acute myocardial infarction (AMI) at different sites of infarction.
Methods:
A total of 49 patients with anterior wall AMI, 39 patients with inferior wall AMI, 29 patients with acute non-ST segment elevation myocardial infarction (NSTEMI) and 20 patients with unstable angina pectoris (UA) were enrolled in this study. (BNP), left ventricular end-diastolic diameter (LV), ejection fraction (EF) and so on were recorded and compared between the two groups.
Results:
Renin 16.73 (8.42, 33.12) in the anterior wall AMI group, Renin 18.98 (8.30,30.41) in the inferior wall AMI group and Renin 15.27 (P = 0.009) in the NSTEMI group were significantly higher than those in the UA group (P <0.05). There was no significant difference between the two groups (P> 0.05). There was no significant difference in the level of Renin between the two groups (P> 0.05). Renin and ATII were correlated with Rs = 0.157 (P <0.05). ALD was correlated with ATII (Rs = 0.325, P <0.01).
Conclusion:
The level of Renin in the early stage of AMI was higher than that in the control group. There was no significant difference in the Renin level between the two groups. There was no significant difference in ATII and ALD between the two groups, but there was correlation between Renin, ATII and ALD.
2018 Vol. 24 (1): 90-95 [
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59
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135
Effect of Photodynamic Therapy Combined with Hormone Therapy on the Improvement of VSS Score and Expression of p-STAT3 and Egr-1 in Patients with Hypertrophic Scars
NING Jinbin, FENG Jian
DOI: 10.3969/j.issn.1006-6233.2018.01.036
Objective:
To investigate the effect of photodynamic therapy combined with hormone therapy on the improvement of VSS score and the expression of p-STAT3 and Egr-1 in patients with hypertrophic scars.
Method:
A total of 124 patients with hypertrophic scars treated in our hospital from January 2014 to July 2016 were randomly divided into control group and observation group, with 62 patients in each group. The control group was treated with glucocorticoid alone. The observation group was treated with photodynamic therapy on the basis of the control group. The VSS score and the curative effect were evaluated and analyzed before and after treatment. The levels of p- STAT3, Egr-1 expression.
Results:
After 2 months of treatment, the VSS score of the observation group was significantly lower than that of the control group (P <0.05). The treatment efficiency of the observation group was significantly higher than that of the control group (P <0.05). After treatment, the levels of p-STAT3 and Egr-1 in both groups were significantly decreased (P <0.05), and the two indexes in the observation group were significantly lower than those in the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05).
Conclusion:
The combined use of photodynamic therapy and glucocorticoid can effectively inhibit the expression of p-STAT3 and Egr-1 in patients with hypertrophic scar and reduce the score of VSS, which has better therapeutic effect and has certain safety.
2018 Vol. 24 (1): 135-139 [
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45
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145
Effects of Different Doses of Dexmedetomidine combined with Dexamethasone on the Levels of Inflammatory Cytokines and Histamine in rats with Lung Ischemia-reperfusion Injury
LI Guanjun
DOI: 10.3969/j.issn.1006-6233.2018.01.039
Objective:
To investigate the effects of different doses of dexmedetomidine combined with dexamethasone on the levels of inflammatory cytokines and histamine in rats with lung ischemia-reperfusion injury.
Methods:
50 SD rats were randomly divided into four groups: sham operation group, model group, dexmedetomidine high dose group, dexmedetomidine group, dexmedetomidine low dose group, each group of 10 rats. According to the literatures, the model of lung ischemia-reperfusion injury was established. After the modeling, dexmedetomidine low, middle and high dose group rats were given dexmedetomidine 1, 5, 10μg/kg loading dose, then in 1, 5, 10μg·kg
-1
·h
-1
were treated with continuous infusion of 1H; dexamethasone 0.2 mg/kg, intratracheal instillation, and then to 3 mg/kg intravenous injection; intravenous infusion of saline model group and sham operation group were given the same amount of medication for 4 weeks. The tumor necrosis factor α (TNF-α), interleukin -1 β (IL-1β), histamine (HIS) and leukotriene B4 (LTB4) levels were observed and compared in each group.
Results:
Compared with model group, dexmedetomidine group and high dose of dexmedetomidine in dose of TNF- α, IL-1β, HIS and LTB4 levels were decreased, the difference was statistically significant (P<0.05), TNF- α, IL-1β, HIS and LTB4 levels in dexmedetomidine high dose group and dexmedetomidine dose group, the difference was not statistically significant (P>0.05).
Conclusion:
Dexmedetomidine combined with dexamethasone can control lung ischemia reperfusion rat model of inflammation, reduce the leukotriene and histamine levels, but increase the dose limited protective effect, showed no significant protective effect.
2018 Vol. 24 (1): 145-152 [
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152
Effects of Matrine Pretreatment on Nerve cell Apoptosis and Expression of Bax and Bcl-2 Protein in rats with Cerebral Ischemia and Reperfusion
ZHAO Yanwu, CAI Chunhua, JIANG Song, et al
DOI: 10.3969/j.issn.1006-6233.2018.01.040
Objective:
To observe the effects of matrine pretreatment on the apoptosis of nerve cells and the expression of Bcl-2 and Bax after cerebral ischemia and reperfusion in the brain.
Methods:
60 healthy SD rats were randomly divided into 6 groups, namely sham group, model group, matrine group (4, 8, 16 mg/kg), edaravone group (1 mg/kg). The cerebral ischemia reperfusion injury model was established by suture method in rats. Then neuro-behavior was scored in different time, brain cell apoptosis was determined and the expression of Bax and Bcl-2 were examined.
Results:
Compared by the model group, rats in matrine pretreatment group showed better neurobehavioral score (P<0.05), lower brain cell apoptosis rate (P<0.05), significantly higher expression of bcl-2 protein (P<0.01) and lower expression of Bax protein (P<0.05).
Conclusion:
Matrine shows a neuro-protective role on cerebral ischemia and reperfusion injury in rats and it enhances the expression of Bcl-2 protein and inhibits the expression of Bax protein.
2018 Vol. 24 (1): 152-155 [
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60
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155
Study on the Correlation between Chemerin and CRP and Gestational Diabetes
LIAN Hang, et al
DOI: 10.3969/j.issn.1006-6233.2018.01.041
Objective:
To discuss the levels and clinical significance of chemerin and CRP in the serum of gestational diabetes patients.
Methods:
From March 2016 to February 2017, 100 suspected gestational diabetes women were selected. According to the diagnosis of gestational diabetes, all women were divided into diabetes group (40 cases) and non-diabetic group (60 cases). At the same time, 50 cases of healthy non-pregnant women were selected as control group. The serum chemerin and CRP expression levels of all subjects were tested by enzyme-linked immunosorbent assay and its clinical significance was discussed.
Results:
Comparison of serum chemerin, CRP, FBG, 1h FBG, 2 hFBG and 3 hFBG levels in the control group and non-diabetic group, the difference was not statistically significant (P>0.05). The serum chemerin, CRP, FBG, 1h FBG, 2 hFBG and 3 hFBG levels of the diabetic group were all high non-diabetic group, and the difference was statistically significant (P<0.05). The results of ROC curve analysis showed that serum chemerin and CRP level diagnosis of gestational diabetes had good evaluation value.
Conclusions:
The serum chemerin and CRP in gestational diabetes are at a high level, and the detection of serum chemerin and CRP in pregnant women has certain clinical value in the diagnosis of gestational diabetes.
2018 Vol. 24 (1): 155-158 [
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48
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Expression and Correlation of CerbB-2, EGFR, bcl-2, P53 and Ki-67 in Gastric Carcinoma
HAN Lu, et al
DOI: 10.3969/j.issn.1006-6233.2018.01.042
Objective:
To analyze the expression and correlation of C-erbB-2, EGFR, bcl-2, P53 and Ki-67 in gastric cancer, and to provide the theoretical basis for the prognosis and targeted therapy of gastric cancer.
Methods:
The immunohistochemical staining results of C-erbB-2, EGFR, Bcl-2, P53 and Ki-67 in 193 patients with gastric cancer were analyzed retrospectively.
Results:
C-erbB-2 and EGFR were associated with invasion depth and lymph node metastasis (P<0.05), but not with tumor differentiation (P>0.05); P53 was associated with lymph node metastasis and differentiation (P <0.05), but not with depth (P>0.05); Ki-67 was associated with invasion depth, Ki-67 was associated with invasion depth, lymph node metasis and tumor differentiation (P<0.05). At the same time, the results showed that the indicators were associated with age and sex of patients with gastric cancer (P>0.05). There was a positive correlation between C-erbB-2 and EGFR, Ki-67 and bcl-2, EGFR and Ki-67; bcl-2 was negatively correlated with P53; there was no correlation between the other indexes.
Conclusion:
The expression of C-erbB-2, EGFR, bcl-2, P53 and Ki-67 in gastric carcinoma is related to the clinicopathological features. The combined detection is important for the prognosis and targeted therapy of gastric cancer.
2018 Vol. 24 (1): 159-162 [
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61
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Study on the Correlation between Carotid Vulnerable Plaque and Coronary SYNTAX Score
YAN Hongyu, et al
DOI: 10.3969/j.issn.1006-6233.2018.01.043
Objective:
To study the relationship between the vulnerable plaque of carotid artery and the coronary SYNTAX score, and to explore the predictive effect of carotid atherosclerosis index on SYNTAX score and prognosis in patients with coronary heart disease.
Methods:
315 cases underwent coronary angiography in Chengde central hospital from March 2016 to May 2017 were enrolled in the study. And the SYNTAX score was calculated according to coronary angiography, and divided into four groups: mild group (1 ≤points <21) in 124 cases, moderate group (21≤ points <31) in 63 cases, severe group (more than or equal to 31 points) in 45 cases, the control group of 83 cases (0); At the same time, the situation of carotid artery atherosclerosis was detected by ultrasound, and the number and texture of vulnerable plaques were measured and recorded, and the corresponding evaluation was made.
Results:
The detection rate of vulnerable plaque of carotid artery was compared between the four groups. Compared with the mild group, the control group had a significant difference compared with the severe group (P<0.05). The proportion of vulnerable plaque in carotid artery was compared between the four groups. There was a significant difference between the groups (P<0.05). As SYNTAX score increased, mixed plaques hypoechoic accounted ladder in each group except the severe group increased; the other three groups, high echo mixed echo plaque in each group in proportion gradually increased; plaque heterogeneity was not statistically significant (P>0.05). There was no significant difference between the follow-up patients after 1 months of follow-up after discharge (P>0.05).
Conclusion:
Carotid vulnerable plaques, especially low echo mixed echo plaques are significantly correlated with coronary artery lesions. Ultrasound detection of vulnerable carotid plaques has great clinical value for early diagnosis and prevention of coronary heart disease, and it is worthy of further excavation.
2018 Vol. 24 (1): 163-167 [
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The Changes of Serum Levels of Th1/Th2 Cytokines before and after the Treatment of Active Ulcerative Colitis
WANG Wei, TAN Yuting, LUO Dan, et al
DOI: 10.3969/j.issn.1006-6233.2018.01.044
Objective:
To observe the changes of serum levels of Th1/Th2 cytokin before and after the treatment of ulcerative colitis (UC).
Methods:
58 patients with active UC were selected into UC group while 58 healthy persons as control group. The expression of IL-2、IFN-γ、IL-4、IL-10 in serum were measured at the 3 different time points: before treatment, 3 months and 12 months after treatment.
Results:
Before treatment, the expression of IFN-γ、IL-10 in serum decreased but IL-4 increased in UC group, with statistical differences (P<0.05). 3 months and 12 months after treatment, the expression of IFN-γ in UC group was lower significantly than control group, but no statistical difference was found in UC group. The expression of IL-4 was higher significantly than control group, especially at the time point of 12 months after treatment (P<0.05). The expression of IL-10 was lower than control group, but it increased significantly at the time point of 12 months after treatment (P<0.05). There was no statistical difference in the expression of IL-2 between the two groups (P>0.05).
Conclusion:
It was suggested that the expression of IFN-γ decreased and IL-4 increased in serum during active UC, would inhibit the Th1 cells immune response to limit inflammatory process. During the remission of UC, the expression of IL-4 decreased and IL-10 increased would keep the balance of Th1/Th2 cells gradually.
2018 Vol. 24 (1): 167-170 [
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Effects of Mouse Nerve Growth Factor Combined with Adenosine Cobalt on Serum ESM-1, ET-1, MBP and Hcy in Patients with Diabetic Peripheral Neuropathy
SANG Yiquan, SUN Yan, WANG Ben
DOI: 10.3969/j.issn.1006-6233.2018.01.045
Objective:
To investigate the effects of mouse nerve growth factor combined with adenosine cobalt on diabetic peripheral neuropathy in patients with clinical efficacy and serum on endothelial cell specific molecule -1 (ESM-1), endothelin -1 (ET-1), myelin basic protein (MBP) and homocysteine (Hcy) level of influence.
Methods:
90 patients of diabetic peripheral neuropathy sdmitted in our hospital from April 2016 to July 2017 were selected as research objects. The two groups were treated with Mouse Nerve Growth Factor for Injection after their examination. On this basis, the observation group added adenosine cobalamin injection. Dynamic monitoring and analysis of clinical efficacy of two groups of patients before and after treatment, TSS (neuropathy symptoms questionnaire), TCSS (Toronto clinical scoring system) and VAS (visual analogue scale) score, observation of the two groups of patients with serum ESM-1, ET-1, MBP, Hcy level and nerve conduction velocity.
Results:
After treatment, the total effective rate of the observation group was 86.67% (39/45) superior to that of the control group (68.89% (31/45) (P < 0.05). The scores of TSS, TCSS and VAS in the observation group were all lower than those in the control group (P < 0.05). The serum levels of ESM-1, ET-1, MBP and Hcy in the observation group were lower than those in the control group (P < 0.05). The MNCV and SNCV of the tibial nerve and median nerve in the observation group increased significantly, and the conduction velocity was better than that of the control group (P < 0.05).
Conclusion:
The combination of mouse nerve growth factor and adenosine cobalamin can improve the clinical efficacy and nerve conduction velocity, and decrease serum ESM-1, ET-1, MBP and Hcy levels, as well as TSS, TCSS and VAS scores.
2018 Vol. 24 (1): 170-174 [
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