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2018 Vol. 24, No. 5
Published: 2018-05-31
705
The Protective Effect and Mechanism of Dexmedetomidine after Treatment in Rats with Focal Cerebral Ischemia- reperfusion Injury
CAO Limei, LI Qiang, DONG Zhiqiang, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.001
Objective:
To study the protective effect and mechanism of dexmedetomidine (Dex) after treatment in rats with focal cerebral ischemia- reperfusion injury.
Methods:
A total of 120 healthy Sprague-Dawley (SD) rats were randomly divided into the sham operation group (S group), ischemia reperfusion group (Mod group), dexmedetomidine pretreatment group (Dex1 group, treated with abdominal injection of 50μg/kg Dex of 100μg/mL at 30min before making MCAO models) and dexmedetomidine after treatment group (Dex2 group, treated with intraperitoneal injection of 50μg/kg Dex of 100μg/mL immediately after reperfusion), with 30 rats in each group. Except S group, 24h after ischemia reperfusion, the neurological function (bederson) score was compared between the other groups, the volume of cerebral infarction was determined by TTC staining method, the percentage of infarct was calculated, and levels of neuron specific enolase (NSE), superoxide dismutase (SOD) and malondialdehyde (MDA) were determined by enzyme-linked immunosorbent assay, xanthine oxidase method and thiobarbituric acid method. The expression quantities of response element binding protein (CREB), Bcl-2 and brain-derived neurotrophic factor (BNDF) mRNA and protein in all groups were detected by RT-PCR method and Western blot method. The immunoenzyme labeling assay (SP) was used for immunohistochemical staining.
Results:
There was no significant difference of bederson score between Mod group and Dex1 group, but bederson scores of Mod group and Dex1 group were significantly higher than those of Dex2 group. TTC staining showed that the infarct volume and the percentage of infarct volume in total brain volume in Dex1 group and Mod group were significantly higher than those in Dex2 group. Levels of NSE and MDA in Dex2 group were significantly lower than those in Dex1 group while the SOD level was significantly higher than that in Dex1 group. RT-PCR, Westernblot and immunohistochemical analysis showed that expression quantities and positive expression rates of CREB, Bcl-2 and BDNF mRNA and protein in Dex2 group were higher than those in Mod group and Dex1 group, showing Dex2 group > Dex1 group > Mod group (P < 0.05).
Conclusion:
Dexmedetomidine has certain protective effect in rats with ischemia reperfusion injury. Dexmedetomidine after treatment can enhance the activities of autioxidant enzymes and inhibit oxidative stress reactions in rats with focal cerebral ischemia reperfusion. It also can improve the expression of Bcl-2 and BDNF through regulating response element binding protein (CREB) of cyclic adenosine monophosphate. The protective effect on brain is significant.
2018 Vol. 24 (5): 705-710 [
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69
)
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711
Relationship between Thyroid Function and 25- Hydroxyvitamin D in Newly Diagnosed Elderly Patients with Type 2 Diabetes Mellitus
YANG Ruihua
DOI: 10.3969/j.issn.1006-6233.2018.05.002
Objective:
To investigate the relationship between thyroid function and 25-hydroxyvitamin D in newly diagnosed type 2 diabetes patients.
Methods:
Totally 90 patients with newly diagnosed type 2 diabetes treated in our hospital from February 2016 to February 2017. were divided into normal group [25 (OH) D≥30ng/ml] [30ng/mL≤25 (OH) D<30ng/mL], deficient group 10ng/mL≤5 (OH) D<20ng/mL and serious deficient group <10ng/mL, compared with the serum levels of vitamin D and thyroid function correlation.
Results:
The levels of thyroid stimulating hormone (TSH) and glycosylate hemoglomin (HbA1c) increased gradually with the decrease of 25-hydroxyvitamin D in the newly diagnosed patients with elderly type 2 diabetes. The difference between the four groups was statistically significant (P <0.05). Multivariate linear regression analysis showed that PTH and calcium were positively correlated with 25 (OH) D levels, whereas HbA1c, TSH, and age and 25-hydroxyvitamin D in serum were significantly negative Related (P <0.05).
Conclusions:
HbA1c, TSH, and age are influence 5 of 25-OH(D) deficiency in newly diagnosed type 2 diabetic patients.
2018 Vol. 24 (5): 711-713 [
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86
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714
Ipsilateral Fractures of the Hip and Shaft of the Femur treated with Reconstructive Nailing under the Assistance of an Reduction Device
WANG Wei, ZHANG Min, LIU Jianning, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.003
Objective:
To evaluate the curative effect and surgical skills of reconstructive intramedullary nailing in the treatment of ipsilateral fractures of the hip and shaft of the femur (IFHSFs) with the assistance of an reduction device by percutaneous techniques.
Methods:
From January 2013 to January 2016, 21 adult patients with IFHSFs were enrolled into this study. All the patients were treated with reconstructive nailing (RN) by percutaneous techniques under the assistance of the reduction device. The operation time, reduction time, fluoroscopy time, intra-operative blood loss and preoperative and postoperative pain score of VAS were recorded. Follow-up was conducted to assess the healing of the fractures, the functional recovery and Harris hip score of the affected limbs.
Results:
All the 21 cases were achieved closed reduction. The average operative time, fracture reduction time, fluoroscopy time and blood loss were 74.57±14.17 minutes, 12.69±2.61 minutes, 19.24±11.08 seconds and 130.48±23.29 mL, respectively. All fractures healed well on an average of 5.00±3.33 months. The pain score of VAS in preoperation was significantly less than in postoperation (P <0.05). According to Friedman－Wyman classification 21 cases get good result. There were no significant differences between the Harris hip score of the affected and healthy limbs when the fractures were union.
Conclusions:
IFHSFs treated with RN under the assistance of the reduction-T pin by percutaneous techniques is a good choice for ipsilateral fractures of the hip and shaft of the femur with the advantages of less soft tissue trauma, less complications, less intra-operative blood loss, excellent functional recovery and less cost.
2018 Vol. 24 (5): 714-717 [
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76
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718
The Influence of Suhuang Zhike Capsule Combined with Seretide on the Serum Levels of TNF-α, TGF-β
1
and IgE of Patients with Cough Variant Asthma
WANG Ning, HUO Xiaoying, CHEN Baoqing, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.004
Objective:
To analyze the influence of Suhuang Zhike capsule combined with seretide on the serum levels of tumor necrosis factor-α(TNF-α), transforming growth factor β
1
(TGF-β
1
) and immunoglobulin E (IgE) of patients with cough variant asthma.
Methods:
90 cases of cough variant asthma admitted from March 2015 to September 2016 in our hospital were selected and divided into the control group and the observation group with 45 cases in each group. The control group was treated with seretide, while the observation group was treated with Suhuang Zhike capsule based on the control group, of the serum levels of TNF-α, TGF-β
1
, IgE, eosinophils (Eos) count, fractional exhaled nitric oxide (FeNO), forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), cough symptoms integral, curative effect and incidence of adverse reactions were compared between two groups after treatment.
Results:
After treatment, the serum levels of TNF-α, TGF-β
1
, IgE, Eos, FeNO of observation group were significantly lower than those of the control group(P<0.05), FVC, FEV1, cough symptoms integral and total effective rate of observation group were obviously higher than those of the control group (P<0.05). No severe adverse reactions was found in both groups after treatment(P>0.05).
Conclusion:
Suhuang Zhike capsule combined with seretide is effective in the treatment of patients with cough variant asthma, which could reduce the levels of serum TNF-α, TGF-β
1
, IgE.
2018 Vol. 24 (5): 718-721 [
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75
)
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722
Clinical Value Analysis of Combined NT-pro BNP hs-CRP and D-D in Acute Myocardial Infarction
WANG Jing, SHANG Lihua, XIONG Weiguo, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.005
Objective:
To investigate the clinical value of combined detection of NT-proBNP, hs-CRP and D-D in patients with acute myocardial infarction
Methods:
72 patients with acute myocardial infarction (AMI) admitted to our hospital from October 2015 to October 2017, 52 patients with non-acute myocardial infarction admitted to our hospital at the same period were enrolled in this study. BNP, hs-CRP DD and other indicators, at the same time compare the different levels of cardiac function in patients with indicators of the level of BNP, hs-CRP and DD levels of the correlation between the indicators.
Results:
The levels of BNP, hs-CRP and DD in the observation group were [(426.85 ± 76.35) pg / mL] and [(91.52 ± 30.23) mg / L] respectively in the two groups of patients with no significant difference (P> 0.05) , [(401.56 ± 96.34) mg / L] and [(25.59 ± 5.94) pg / mL] (Killip II-IV) BNP in AMI patients with normal heart function (Killip I group) and AMI patients with heart failure (Killip II-IV) BNP was significantly higher than that in AMI patients (t = 37.78,14.32,14.96,P<0.05). There was no significant difference between hs-CRP level and DD level (P> 0.05). Correlation analysis showed that the level of BNP was positively correlated with the level of hs-CRP (R = 0.584, P <0.05). There was no correlation between other indexes (P> 0.05).
Conclusion:
Combined detection of BNP, hs-CRP and D-D levels in patients with acute myocardial infarction is helpful for the clinical diagnosis of patients, and combined detection can help to determine the patient's cardiac function classification.
2018 Vol. 24 (5): 722-724 [
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95
)
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725
Effect of Standard Large Trauma Craniotomy combined with Vascular Reconstruction for Severe Traumatic Brain Injury and the Influence on Cerebral Perfusion
ZHU Shijia, WU Shiqiang, FAN Xiaohong, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.006
Objective:
To study the curative efficacy of standard large bone flap decompression combined with revascularization in treatment of severe craniocerebral injury and its effects on cerebral perfusion.
Methods:
90 patients of severe craniocerebral injury who received therapy from January 2014 to January 2017 in our hospital were selected as research objects. According to random number table, all the patients were divided into the observation group (n=45) and the control group (n=45), the control group was treated with standard large bone flap decompression, while the observation group was combined with brain-duramater-muscle revascularization. The blood rheology, coagulation function, intracranial pressure (ICP), cerebral perfusion volume (CCP), postoperative complications and prognosis were compared between the two groups.
Results:
The blood viscosity, whole blood low shear viscosity, plasma viscosity and hematocrit of the two groups after sugery 7D were significantly lower than those before operation (P < 0.05). On 7 days after operation, the two groups were significantly lower in whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity and hematocrit than before operation (P < 0.05). On 7 days after operation, ICP of the two groups were significantly lower than those before the operation, and the CCP was significantly higher (P < 0.05). The ICP in the observation group was significantly lower than the control group, and the CCP was significantly higher than that of the control group [(16.31 + 1.70) mmHg vs (21.40 ±1.94) mmHg, (64.98±7.30) mmHg vs (57.54±6.19) mmHg]. There was no significant difference in the incidence of intracranial infection, epilepsy, hydrocephalus and incisional hernia between the two groups (P > 0.05). 6 months after operation, the prognosis in the observation group was significantly better than that in the control group (P < 0.05).
Conclusion:
The use of standard large bone flap decompression and vascular reconstruction in patients with severe craniocerebral injury has significant effect. It can effectively improve blood rheology and coagulation function, promote cerebral perfusion, and have less postoperative complications and high prognosis. It is worthy of application.
2018 Vol. 24 (5): 725-729 [
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730
The Clinical Application Value of Umbilical Cord Blood Serum Total Bilirubin Detection in the Early Diagnosis and treatment of ABO Hemolytic Disease of the Newborn
YAO Chaofeng
DOI: 10.3969/j.issn.1006-6233.2018.05.007
Objective:
To explore the clinical value of cord blood serum total bilirubin in the early diagnosis and treatment of neonatal ABO hemolytic disease, and to provide experience and reference for clinical diagnosis and treatment.
Methods:
From October 2015 to October 2017, 320 neonates with ABO blood group mismatch in our hospital were selected as the study samples to detect three indexes of neonatal ABO hemolysis. The serum total bilirubin level of umbilical cord blood was measured by automatic biochemical analyzer, and the relationship between serum total bilirubin and maternal and infant blood group, time of jaundice and hemolysis was analyzed.
Results:
There was no significant difference between maternal and infant O - A blood type and mother - to - infant O - B blood type in the incidence of ABO hemolytic disease , incidence of high bilirubin , total bilirubin in cord blood serum , anti - human globulin test and release test. In the age of less than or equal to 3 days of neonatal umbilical cord blood serum total bilirubin was significantly higher than that of age greater than 3 days in neonatal hyperbilirubinemia, the difference was statistically significant (P<0.05). Coombs test positive children's umbilical cord blood total bilirubin was significantly higher than that of antiglobulin test negative patients, the difference was statistically significant (P<0.05).
Conclusion:
The three detection of serum total bilirubin and hemolysis of umbilical cord blood in neonates with ABO incompatible blood group is of great significance in the early diagnosis and treatment of ABO hemolytic disease of the newborn.
2018 Vol. 24 (5): 730-733 [
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73
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734
Effect of Midazolam combined with Early Mechanical Ventilation on the Cerebral Oxygenation Index Lung Function and Serum Inflammatory Factors in Children with Severe Hand-Foot-Mouth Disease
HU Dandan, HE Liya, LI Peiqing, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.008
Objective:
To explore the effect of midazolam combined with early mechanical ventilation on the cerebral oxygenation index, lung function and serum inflammatory factors in children with severe hand-foot-mouth disease (HFMD).
Methods:
60 children with severe HFMD who underwent mechanical ventilation in the pediatric intensive care unit of the hospital were randomly divided into the routine and the study group. All children were given nutritional support and anti-inflammatory treatment. On the basis, the study group was treated with intravenous injection of midazolam. The condition of hospitalization and prognosis was compared between the two groups. The cerebral oxygenation metabolism indexes, including cerebral oxygen consumption, cerebral oxygen extraction rate and amount of lactic acid produced in the two groups were calculated before and after treatment. The lung function and serum inflammatory factors were detected. The incidence of adverse reactions during treatment and the prognosis were statistically analyzed.
Results:
The length of ICU stay and duration of mechanical ventilation in the study group was shorter than that in the control group (P<0.05). After treatment, the cerebral oxygen consumption and amount of lactic acid produced in the study group [(57.3±9.3)%, (0.15±0.02) mmol/L] were significantly lower than those in the routine group [(67.7±12.6)%, (0.17±0.05) mmol/L], and the cerebral oxygen extraction rate [(62.3±11.2)%] was significantly higher than that in the routine group [(52.5±10.3)%] (P<0.05). The PEF, FVC and FEV1 in the study group [(86.4±7.5)%, (73.7±10.7) L, (83.7±12.3)%] were significantly higher than those in the routine group [(80.5±7.2)%, (65.7±9.8) L, (74.5±10.7)%] (P<0.05). Serum inflammatory cytokines IL-6, TNF-ɑ and PCT in the study group were significantly lower than those in the normal group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (10% vs 13.3%) (P>0.05).
Conclusion:
Midazolam combined with early mechanical ventilation can effectively improve the cardiopulmonary function and oxygenation index in children with severe HFMD, and promote their recovery.
2018 Vol. 24 (5): 734-737 [
Abstract
] (
69
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738
Analysis on Vitrectomy combined with Air Filtration for Vitreoretinal Diseases
GONG Lanlan
DOI: 10.3969/j.issn.1006-6233.2018.05.009
Objective:
To investigate the clinical effect of vitrectomy combined with air filtration in the treatment of vitreoretinal diseases.
Methods:
102 patients with monocular vitreoretinal diseases who were admitted to hospital from May 2015 to May 2017 were randomly divided into two groups. Patients in filtration air group were treated with vitrectomy combined with filtered air filling. Patients in C
3
F
8
group were treated with vitrectomy combined with C
3
F
8
Gas filling, visual acuity, intraocular pressure, central macular thickness, central anterior chamber depth, complications and long-term quality of life were compared before and after treatment.
Results:
Compared with C
3
F
8
Gas group, the BCVA, intraocular pressure and OCT levels in the filtered air group were significantly lower than those in the C
3
F
8
gas group; the ACD was significantly higher than that of the C
3
F
8
gas group; the gas absorption time was significantly lower than that of the C
3
F
8
gas group; There was a significant difference between the three groups (P<0.01). The overall complication was significantly lower than that of the control group (P <0.05) .
Conclusion:
Vitrectomy combined with filtering air filling has significant clinical effect in the treatment of vitreoretinal diseases.
2018 Vol. 24 (5): 738-741 [
Abstract
] (
55
)
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742
The Application Value of Reduced Glutathione in Patients with Acute Organophosphorus Pesticide Poisoning
GUO Yongjun, KONG Yuanyuan, XIAO Jinghua, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.010
Objective:
To investigate the value of reduced glutathione (GSH) in the treatment of acute organophosphorus pesticide poisoning (AOPP).
Methods:
170 AOPP patients treated in the emergency department of our hospital from January 2013 to December 2016 were selected as the research object. According to the random number table method divided into two groups, 85 cases in each group, the control group were treated with routine treatment of atropine and pralidoxime chloride, observation group combined with reduced glutathione treatment, treated for 7 days. The clinical parameters and the changes of serum Cholinesterase (CHE) and cardiac troponin I (cTnI) were compared between the two groups.
Results:
At the 24h, 3d, 7d, the CHE of the observation group were significantly higher than the control group, and cTnI were significantly lower, the difference was of statistically significant (P < 0.05); the dosage of atropine and hospitalization time in observation group were (258.69±114.27) mg, (10.13±3.24) days, significantly less than the control group (316.52±131.46) mg, (13.75±4.58) days, the observation group rebound rate (3.53%) was lower than in the control group (11.76%), the differences was of statistically significant (P < 0.05).
Conclusion:
The reduced glutathione can be used in the treatment of acute organophosphorus pesticide poisoning, which can effectively prevent myocardial damage and shorten the course of disease.
2018 Vol. 24 (5): 742-744 [
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85
)
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745
Influence of Somatostatin on Serum Levels of Occludin IL-8 and IL-2 and Mucosal Barrier Function of Patients with Severe Acute Pancreatitis
FU Xiaolin, DUAN Ying, ZHANG Yi, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.011
Objective:
To investigate the influence of somatostatin on the levels of occludin, interleukin-8 (IL-8) and interleukin-2 (IL-2) and mucosal barrier function of patients with severe acute pancreatitis.
Methods:
From October 2014 to October 2016, 98 patients with acute severe pancreatitis admitted in our hospital were selected and divided into the control group and the experimental group, with 49 cases in each group according to different treatment methods. The control group was treated with conventional western medicine, while the experimental group was treated with somatostatin on the basis of control group. Then the curative effect, bowel sounds, first defecation, abdominal pain, abdominal distension relief, 3 days and 7 days after treatment, serum levels of occludin, IL-8, IL-2, urinary lactulose/mannitol (L/M) urine, D-lactic acid, APACHE Ⅱ score and incidence of adverse reactions before and after treatment were observed and compared between the two groups.
Results:
After treatment, the total effective rate was higher than that of the control group, and the bowel sounds, first time defecation, abdominal pain, abdominal distension relief time of experimental group were significantly shorter than those of the control group (P<0.05). The serum occludin and IL-2 levels of experimental group were significantly higher than those before treatment (P>0.05). The above indicators of experimental group were significantly higher than those of the control group; the serum IL-8, urine L/M value, D-lactic acid, APACHE Ⅱ scores of both groups were significantly lower than those before treatment, and the above indicators of experimental group were significantly lower than those of the control group (P<0.05). The incidence rate of adverse reaction showed no differences between the two groups (P>0.05).
Conclusion:
Somatostatin adjuvant therapy can improve the clinical efficacy in the treatment of patients with acute severe pancreatitis, alleviate the barrier of the mucosa barrier and improve the serum occludin, IL-8 and IL-2 levels.
2018 Vol. 24 (5): 745-748 [
Abstract
] (
51
)
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749
The Value of CT Annular Calcification in Diagnosis and Differential Diagnosis of Benign and Malignant Thyroid Nodules
CHEN Dandan
DOI: 10.3969/j.issn.1006-6233.2018.05.012
Objective:
To explore CT annular calcification in the value of diagnosis and differential diagnosis of benign and malignant thyroid nodules, and provide guidance for clinical diagnosis of benign and malignant thyroid nodules.
Methods:
From August 12, 2016 to August 25, 2017, 56 cases of thyroid nodules treated in our hospital were confirmed by surgery and pathology. 56 cases of thyroid nodules were diagnosed by CT. The operative pathology results were the gold standard for diagnosis. The results of CT diagnosis and surgical pathology were compared. The value of CT annular calcification in diagnosis and differential diagnosis of benign and malignant thyroid nodules were compared.
Results:
The sensitivity, specificity and accuracy of CT in the diagnosis of benign and malignant thyroid nodules were 94.87%, 88.24% and 92.86% respectively. Comparing the diagnostic results with the results of pathological diagnosis, there was no significant difference between the two groups (P>0.05). There was a significant difference between enhanced thyroid nodules and thyroid nodules with enhanced margins and high enhancement results (P<0.05).
Conclusion:
CT cyclic calcification has a significant effect on the diagnosis of thyroid benign and malignant nodules, with high sensitivity, specificity and accuracy, which is worthy of the application and promotion of various medical institutions.
2018 Vol. 24 (5): 749-751 [
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] (
42
)
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752
The Prophylactic Effect of Propofol on the Preventive Effect of Cesarean Section Postoperative Adverse Reactions of Hemabate and the Influence on Hemodynamics
CAO Xiuling, XU Mingjun
DOI: 10.3969/j.issn.1006-6233.2018.05.013
Objective:
To analyze the preventive effect of propofol on cesarean section hemabate adverse reactions and influence on hemodynamics.
Methods:
86 cases of caesarean section were received therapy from January 2017 to October 2017. According to the random table method, those patients were divided into control group and research group, 43 cases in each group. Both groups were given epidural anesthesia, intravenous infusion of 10U oxytocin after childbirth, and in the palace injection of 250μg hemabate. The patients in the study group were immediately given intravenous infusion of 3mg.kg/min propofol, while the control group was intravenously injected with the same amount of normal saline. The adverse reactions, hemodynamics and operation before and after operation were compared between the two groups.
Results:
The incidence of flushing, chest tightness, nausea and vomiting, dizziness and headache in the study group were lower than those in the control group (P<0.05). Before operation, there was no difference in heart rate (HR), diastolic pressure (DBP), systolic pressure (SBP), respiratory frequency (RR) and oxygen saturation (SpO
2
) in two groups (P>0.05). After operation, two groups of HR, DBP, SBP and RR all increased, SpO
2
decreased correspondingly, and the amplitude of change in the study group was smaller than that in the control group (P<0.05). There was no difference in bleeding volume, extubation time and operative time between the two groups (P>0.05).
Conclusion:
The effect of propofol on prevention of adverse reactions that cesarean section of hemabate, can reduce maternal discomfort. It is more conducive to the stability of hemodynamics, and has certain guiding value for clinical work.
2018 Vol. 24 (5): 752-754 [
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] (
61
)
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755
Expression and Clinical Significance of Atrial Natriuretic Peptide in Gastric Cancer
LI Xiaowen, LI Chunhui
DOI: 10.3969/j.issn.1006-6233.2018.05.014
Objective:
To study the expression of atrial natriuretic peptide (ANP) in gastric cancer and explore its clinical significance in the development and progression of gastric cancer.
Methods:
Immunohistochemistry was used to detect the expression of ANP in 40 cases of gastric cancer after resection and 20 cases of normal gastric mucosa. The relationship between the expression of ANP in gastric cancer tissue and the clinicopathological features of the patients' sex, age, degree of differentiation, depth of infiltration, regional lymph node metastasis, tumor stage and tumor typing were analyzed.
Results:
The positive expression rate of ANP in normal gastric mucosa was 95% (19/20), which was strongly positive. The positive expression rate of ANP in gastric cancer tissues was 90% (54/60), which was weakly expressed. The expression of ANP in normal gastric mucosa was stronger than that in cancer tissue (P<0.05).The expression intensity of ANP in gastric carcinoma was positively correlated with the degree of tumor differentiation (P<0.01, r=0.383), which was negatively correlated with the depth of invasion (P<0.01, r=-0.499), negatively correlated with lymph node metastasis (P<0.01, r=-0.396), and negatively correlated with tumor stage (P<0.01, r= -0.519). The expression intensity of ANP gradually weakened with infiltration depth, lymph node metastasis and stage failure. In addition, the expression intensity of ANP was not correlated with gender, age and tumor type (P>O.05).Multiple factor analysis showed that the degree of differentiation of the tumor was independent of these clinicopathological features affecting the expression of ANP in gastric cancer (P=0.013, 95%CI=1.493 to 27.207, OR=6.256).
Conclusion:
The expressions of ANP in normal tissues is higher than gastric carcinoma. The ANP expressions of gastic cacinoma is higher in better differentiation degree, but the expressions more decreased in deeper invasion, higher TNM stage and lymph node metastasized. There is no correlation among the groups in gender, age, and classification. So ANP correlates with the occurrence and development of gastric cancer gastric cancer, could be used as biological targeted drug.
2018 Vol. 24 (5): 755-759 [
Abstract
] (
84
)
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760
Logistic Regression Analysis of High-risk Factors for Death on Children's Refractory Mycoplasma Pneumoniae
ZHU Ying, WANG Jing
DOI: 10.3969/j.issn.1006-6233.2018.05.015
Objetive:
To explore the risk factors and clinical significance of refractory Mycoplasma pneumoniae pneumonia (RMPP).
Methods:
The clinical data of 109 children with Mycoplasma pneumoniae were retrospectively analyzed. The clinical data of 49 cases of refractory Mycoplasma pneumoniae pneumonia and 60 cases of Mycoplasma pneumoniae pneumonia (MPP) were compared, and Logsitic regression analysis was performed.
Results:
RMPP had a long >10 day with a long duration of heat and high incidence of extrapulmonary complications. The imaging changed in a large area of one side of the lung, involving two lobes above the lobes, and pleural effusion, especially in the right upper lung. CRP (C reactive protein) and LDH (lactate dehydrogenase) were significantly higher in the laboratory. Logsitic regression analysis showed that the independent risk factor for RMPP was long heat course, multiple pleural effusion, right upper lung disease, CRP and LDH increased significantly (P <0.05).
Conclusions:
Thermal process is more than 10 days, mainly seen on the top of the right lung, CRP>40mg/L, LDH>410U/L. It raises a clinical significance of distinguish early period of RMPP.
2018 Vol. 24 (5): 760-762 [
Abstract
] (
54
)
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763
Clinical Effect of Tirofiban Combined with Clopidogrel on Acute Myocardial Infarction and the Levels of IL-6, TNF-α and hs-CRP in Serum
ZHANG Ming, HOU Jianwei, WANG Xihui, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.016
Objective:
To explore the clinic effect of tirofiban (TIR) combined with clopidogrel (CLO) on acute myocardial infarction (AMI) and the levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and high sensitivity C-reactive protein (hs-CRP) in serum.
Methods:
119 cases of patients with AMI admitted in our hospital from January 2015 to January 2017 were selected as research objectives, and according to simple random method, those patients were divided into two groups. The observation group (60 cases) was treated by TIR combined with CLO, while the control group (59 cases) was treated by CLO. The clinical effect, changes of serum IL-6, TNF-α, hs-CRP levels before and after treatment as well as the incidence of adverse reactions were compared between two groups.
Results:
After treatment, the overall effective rate of observation group was 95.0%, which was significantly higher than that of the control group (81.4%, P<0.05). The serum IL-6, TNF-α, hs-CRP levels of both groups after treatment were significantly lower than those before treatment (P<0.01), and the serum IL-6, TNF-α, hs-CRP of the observation group were significantly lower the in the control group at same time (P<0.01). The total incidence of adverse reactions in the two groups was 6.7% and 5.1%, respectively, and there was no significant difference between the two groups. (P>0.05).
Conclusion:
Tirofiban combined with clopidogrel could effectively control the inflammation and improve the treatment effect with high safety.
2018 Vol. 24 (5): 763-766 [
Abstract
] (
77
)
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151
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767
The Effectiveness of Two Different Intraocular Lenses Bigbag and Rayner 620H in Cataract and High Myopia Eyes
ZHENG Li, LI Min
DOI: 10.3969/j.issn.1006-6233.2018.05.017
Objective:
To investigate the clinical effect of two different intraocular lens implantation in the treatment of cataract with high myopia.
Methods:
From September 2013 to January 2016, 98 cases of cataract phacoemulsification and intraocular lens implantation in the ophthalmological center of our hospital were retrospectively analyzed. Among them, 50 cases (68 eyes) were given Bigbag intraocular lens, and 48 cases (63 eyes) were given Rayner 620H intraocular lens. The effect of the two groups were compared.
Results:
Before operation, there were no significant differences in the two groups of patients with macular central retinal thickness, axial value, the best corrected visual acuity, and intraocular pressure (IOP) were not statistically significant (P>0.05); At 1 months and 3 months after operation, the Bigbag group of Rayner group had significantly lower than the 620H Rayner group (P<0.05), and the best corrected visual acuity was significantly better than that of the 620H Bigbag group (P<0.05); 1 months and 3 months after surgery, the degree of numerical optometry of two groups of patients were significantly lower than that before operation (P<0.05); 3 months after surgery, Bigbag group, posterior capsular wrinkle opacification were significantly lower than Rayner group 620H (P<0.05).
Conclusion:
Bigbag intraocular lens is more effective in cataract patients with high myopia.
2018 Vol. 24 (5): 767-770 [
Abstract
] (
102
)
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(1598 KB) (
135
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771
Clinical Curative Effect of Calcitonin combined with Alfacalcidol in the treatment of Osteoporotic Distal Radius Fractures in the Elderly
YE Pengsheng
DOI: 10.3969/j.issn.1006-6233.2018.05.018
Objective:
To observe the clinical curative effect of calcitonin combined with alfacalcidol in the treatment of osteoporotic distal radius fractures in the elderly.
Methods:
90 elderly patients with osteoporotic distal radius fractures who were admitted to the hospital from March 2015 to June 2017 were selected and randomly divided into the treatment group and the control group, 45 cases in each group. All patients were treated by open reduction and internal fixation. The treatment group was treated with salmon calcitonin 50U/ times +0.25 μg/times and twice/d of alfacalcidol after operation, while the control group was only treated with alfacalcidol. All patients were treated for 3 months. The visual analogue scale (VAS) scores and bone mineral density (BMD) in the two groups were determined. The length of hospital stay, fracture healing time, excellent and good rate of wrist function recovery and adverse reactions were statistically analyzed.
Results:
After treatment, VAS scores of the two groups were significantly decreased while BMD of lumbar vertebra L2-4 and femoral neck were significantly increased(P < 0.05).After treatment, the VAS score in the treatment group was significantly lower than that in the control group, BMD of lumbar vertebra L2-4 and femoral neck were significantly higher than those in the control group, the length of hospital stay and fracture healing time were significantly shorter than those of the control group (P < 0.05). The excellent and good rate of wrist function recovery in the treatment group was significantly higher than that in the control group (91.11% vs 73.33%) (P < 0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups (P > 0.05).
Conclusion:
Calcitonin combined with alfacalcidol is effective and safe in the treatment of osteoporotic distal radius fractures in the elderly.
2018 Vol. 24 (5): 771-773 [
Abstract
] (
94
)
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226
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774
The Correlation of the Tumour Necosis Factor -308 Gene Polymorphism Response to Etanercept Treatment in Rheumatoid Arthritis
YANG Qunzhi, ZHANG Ge, HE Jing
DOI: 10.3969/j.issn.1006-6233.2018.05.019
Objective:
To study the effect of TNF gene polymorphism on the efficacy of etanercept in the treatment of rheumatoid arthritis.
Methods:
103 patients with rheumatoid arthritis were selected in this study. included. The polymorphism of TNF- alpha -308 (G/A) gene was analyzed in patients. and the patients were divided into three groups: GG, GA and AA. All patients were treated with etanercept (25 mg/ times, 1 weeks, 2 times). At 4 weeks, 8 weeks and 12 weeks, we evaluated whether the patients achieved the ACR20 and ACR50 mitigation criteria. The improvement of patients with different genotypes were observed.
Results:
After 12 weeks of therapy, ACR20 and ACR50 criterion were met by 94.8% and 70.0% in GG group; 78.4% and 59.5% in GA group; 62.5% and 37.5% in AA group. The ACR20 and ACR50 in GG group were significant higher than that of GA and AA groups, the difference was statistically significant( P < 0.05 ).
Conclusion:
The polymorphism of TNF- alpha -308 (G/A) gene is correlated with the clinical efficacy of etanercept in patients with rheumatoid arthritis. The effect of etancept on patients with TNF- alpha -308GG type rheumatoid arthritis is better than those with GA and AA genotypes. The difference of therapeutic effect between different types of gene types gradually appears with the prolongation of the time of treatment.
2018 Vol. 24 (5): 774-777 [
Abstract
] (
51
)
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132
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778
Effect of Fluid Therapy Guided by SVV on Coagulation Function in Elderly Patients with Hypercoagulable Colon Cancer
YANG Chaojie, GAO Xiaozeng, TAN Zhibin, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.020
Objective:
To investigate the effect of liquid therapy guided by SVV on the coagulation function of the elderly patients with hypercoagulable colon cancer.
Methods:
120 cases of senile hypercoagulability (thrombus and elastic map CI>3) were selected in our hospital for radical resection of colon cancer. The random digital table was used to divide into the liquid treatment group (group S) guided by SVV and the liquid treatment group (group C) guided by CVP, with 60 cases in each group. Recording and analysis of two groups of patients before anesthesia (T
0
), at the beginning of the operation (T
1
), one hour of operation(T
2
), at the end of operation (T
3
), hemodynamics and oxygen index for four points and thromboelastogram coagulation reaction time (R), blood clotting time (K), blood clot formation rate (alpha angle), maximum amplitude (MA), coagulation index (CI) changes.
Results:
The amount of liquid input in group S was lower than that in group C (P<0.05). Compared with the C group, the MAP, CVP and Lac of the S group were lower than those of the C group at (T
1
), (T
2
) and (T
3
). SVV, ScvO
2
, and DO
2
I were all higher than those in the group (P< 0.05). Compared with T
0
, the two groups of patients (T
1
), (T
2
), (T
3
), the R value and K value became larger, and the alpha and CI were smaller (P < 0.05). Compared with the group C, the coagulation factor, fibrinogen and coagulant function were stronger than group S at (T
1
), (T
2
) and (T
3
) (P < 0.05).
Conclusion:
The liquid therapy guided by SVV is helpful to maintain the stability of coagulation function during the operation of the elderly patients with colon cancer with hypercoagulability, and to correct the hypercoagulability.
2018 Vol. 24 (5): 778-781 [
Abstract
] (
76
)
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404
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782
Influence of Ambroxol joint Reynolds Nasal Spray on Serum and Middle Ear Effusion on HA,sIL-2R, Fn and Inflammatory Media in the Treatment Secretory Otitis Media
YAN Bin, WU Wenwen, LIU Bo, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.021
Objective:
To research Influence of ambroxol joint Reynolds nasal spray on serum and middle ear effusion on hyaluronic acid (HA), Soluble interleukin-2 receptor (sIL-2 R), fibronectin (Fn) and inflammatory media in the treatment secretory otitis media.
Methods:
86 cases of secretory otitis media was from May 2013 to November 2016, according to lottery method was divided into control group and research group, 43 cases in each group. The control group was treated with the basic treatment, and the research group was treated with ambroxol joint Reynolds nasal spray based on control group. Clinical curative effect, serum HA and middle ear effusion, sIL-2 R, Fn, interleukin 1β (IL-1β), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), procalcitonin (PCT), and adverse reactions occur between two group were observed and compared.
Results:
Total effective rate of the research group was significantly higher than the control group, and the difference was statistically significant (P<0.05). After treatment, two groups of serum and middle ear effusion HA, sIL-2 R, IL-1β, IL-8, TNF-α, PCT was significantly lower than befroe treatment, research group was significantly lower than the control group, Fn of two group was significantly higher than control group, the control group was significantly higher than the control group, the differences were statistically significant (P<0.05). The total adverse effects rate of two group was not statistically significant (P>0.05).
Conclusion:
Effect is sure of ambroxol joint Reynolds nasal spray in the treatment secretory otitis media,wich can reduce serum and middle ear effusion HA, sIL-2R and inflammatory mediators, improve the level of Fn.
2018 Vol. 24 (5): 782-785 [
Abstract
] (
85
)
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258
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786
Effect of Nimodipine combined with Fasudil Hydrochloride SAC Vasospasm of Postoperative Acute Hemorrhage of Intracranial Aneurysm
WU Jie, ZHOU Ye
DOI: 10.3969/j.issn.1006-6233.2018.05.022
Objective:
To evaluate the effect of Nimodipine combined with Fasudil hydrochloride in the treatment of Cerebral vasospasm of intracranial aneurysms after acute hemorrhagic by SAC after operation.
Methods:
A total of 86 patients with crebral vasospasm of intracranial aneurysms after acute hemorrhagic by SAC were selected and randomly divided into 2 groups, 43 cases each. The control group received nimodipine infusion micro pump injection 10mg, tid, the treatment group received nimodipine infusion micro pump injection 10mg, tid,+ fasudil hydrochloride micro pump injection 30mg, tid, and 2 groups were treated for 14days. Nerve function defect score (National Institutes of health neurological impairment score, NIHSS), Glasgow coma score (Glasgow Coma Scale, GCS), Barthel (the Barthel index of index ADL) evaluated, blood samples were collected to determine the levels of Fatty acid binding protein (FABP) and Neuron specific enolase (NSE), and blood flow velocity of middle cerebral artery (MCA) were determined and clinical effect were also compared.
Results:
After the treatment, the NIHSS scores in the control group and the treatment group were (10.97±3.98), (7.61±3.86), GCS scores were (11.19±2.85), (13.56±3.04) Barthel scores were respectively (48.37±11.24), (59.68±12.30), levels of FABP (521.23±118.75), (397.02±97.45) ng/L, NSE were respectively (14.82±3.71), (11.64±3.59) ug/L, MCA were respectively (123.20±21.14), (138.69±21.36) cm/s, the above indexes in the control group and treatment group had statistical significance (P<0.05), the total efficiency of the control group76.74% was lower than the treatment group 93.02% (P<0.05), and the incidence of cerebral infarction within 30 days in the control group18.60% was higher than the treatment group 4.65%(P<0.05).
Conclusion:
Nimodipine combined with fasudil hydrochloride can relieve cerebral vasospasm of intracranial aneurysms after acute hemorrhagic by SAC, reduce neurological damage, promote brain perfusion, is worthy of clinical application.
2018 Vol. 24 (5): 786-790 [
Abstract
] (
55
)
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139
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791
Clinical Research of Ilaprazole Sequential in treatment of Peptic Ulcer and the Effects on Serum Gastrin and Gastrin Gene Expression
WU Dawei, YANG Yushuang, CUI Qingzhi, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.023
Objective:
To study clinical research of Ilaprazole sequential in treatment of peptic ulcer and the effects on serum gastrin and gastrin gene expression.
Methods:
80 patients of peptic ulcer who received therapy from March 2015 to March 2016 in our hospital were selected as research objects. According to the draw method divided into control group and experimental group, all the 40 cases. The control group was treated with routine treatment, oral omeprazole, Clarithromycin Capsules, Furazolidone Tablets. while the observation group was treated with Ilaprazole sequential, Ilaprazole Enteric-coated Tablets, Clarithromycin Capsules, Furazolidone Tablets oral. Then symptom relief, healing time, healing rate, HP eradication time, HP eradication rate, serum gastrin and gastrin gene expression, adverse reaction rate, treatment effect of two groups were compared.
Results:
The symptom relief, healing time, healing rate, HP eradication time and HP eradication rate in the experimental group were significantly lower than those in the control group[92.50%(37/40)vs75.00%(30/40),(6.93±1.35)week vs(3.29±0.74)week,92.50%(37/40)vs75.00%(30/40),(7.49±1.67)d vs(10.86±2.45)d,95.00%(38/40)vs75.00%(30/40)](P<0.05); The gastrin and gastrin gene expressions were significantly lower than those in the control group [(24.57±6.04)pmoL/L vs(28.09±6.37)pmol/L,(0.13±0.02)pmol/L vs(0.25±0.05)pmoL/L] (P<0.05); The total incidence of adverse reactions was significantly lower than that of the control group[10.00%(4/40)vs42.50%(17/40)](P<0.05); The total effective rate was significantly higher than that of the control group[95.00%(38/40)vs70.00%(28/40)] (P<0.05).
Conclusion:
Ilaprazole sequential is well for peptic ulcer, which can reduce the local inflammatory reaction of ulcer, reduce gastric acid secretion, reduce serum gastrin level and gastrin gene expression, and can significantly improve therapeutic efficacy and safety of medication.
2018 Vol. 24 (5): 791-793 [
Abstract
] (
71
)
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344
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794
Sericin Inhibits Retinal Neuron Apoptosis in Diabetic Rat via Regulation of JNK Signaling Pathway
DONG Zhijun, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.024
Objective:
This study was to investigate the effects of sericin on the inhibition of retinal neuron apoptosi via regulation of JNK signaling pathway in diabetic rat.
Methods:
The diabetic rat models were established by feeding high lipid foods and intraperitoneal injection of small-dose streptozotocin. Rats were randomly divided into three groups, sericine-treatment group, diabetes model group and normal control group. The sericin solution dissolved in normal saline solution 2.4 g·kg
-1
·d
-1
was used for 35 days in gavage method in the sericin-treated group. The rats were sacrificed by an overdose of anesthesia and retinal sections were prepared. The expressions of phosphorylation c-Jun N-terminal kinase( p-JNK),Cytochrome(Cyt-c)and Cysteine aspartate kinase 9(caspase-9)in retinas in protein levels were detected by Western blot . The activity of Cysteine aspartate kinase 3(caspase-3)in the retina was detected by spectrophotometry. TUNEL staining was employed to detect retinal neuron apoptosis.
Results:
The relative expression levels of p-JNK, Cyt-c and caspase-9 proteins, the activity of caspase-3,the apoptotic index(AI) in rat retinas in the sericintreated group were significantly lower than those in the diabetic model group (all at P<0.05).
Conclusion:
Sericin can inhibit retinal neuron apoptosis by regulating JNK signaling pathway in diabetic rats.
2018 Vol. 24 (5): 794-796 [
Abstract
] (
67
)
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(1314 KB) (
142
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797
Effect of Xiyanping Injection Combined with Aminophylline on Blood Gas Index and Serum TNF-α, IL-8 and IL-10 Levels of Patients with Acute Exacerbation of Chronic Bronchitis
WANG Chunchang, JIN Yang, YANG Cui, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.025
Objective:
To investigate the effect of Xiyanping injection combined with aminophylline (Ami) on the blood gas index and serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-8 and IL-10 of patients with acute exacerbation of chronic bronchitis (AECB).
Methods:
142 cases of AECB patients admitted in our hospital from April 2015 to April 2017 were selected. According to simple random method, those patients were divided into two groups. The control group was treated with Ami while the observation group was given the combination of Ami and Xiyanping injection. The changes of blood gas indexes, serum TNF-α, IL-8, IL-10 levels before and after treatment, clinical effect as well as the incidence of adverse reactions were compared between the two groups.
Results:
After treatment, the value of PaO
2
was significantly increased, and the PaCO
2
value decreased significantly (P< 0.01), the PaO
2
in observation group was higher than that in the control group, and PaCO
2
was less than that in the control group (P< 0.01). After treatment, TNF-α, IL-8 in the serum of the patients were significantly decreased, and the levels of IL-10 were significantly increased (P< 0.01), TNF-α, IL-8 in the observation group were less than the control group, IL-10 was higher than the control group (P< 0.01). After treatment, the total effective rate of observation group was higher than the control group (P< 0.05). The incidence of adverse reactions was not statistically significant (P>0.05).
Conclusion:
Xiyanping injection combined with aminophylline treatment of chronic bronchitis acute episodes can rapidly improve the patients' lung function, improve clinical curative effect, to significantly reduce the level of serum TNF alpha, IL - 8 and raise the level of serum IL - 10, inhibit the body's inflammatory response and improve immune function.
2018 Vol. 24 (5): 797-801 [
Abstract
] (
73
)
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(1346 KB) (
232
)
802
Clinical Comparison of Laparoscopic Radical Cystectomy and Open Surgery
SU Zhouquan, YU Liyun, WEI Sujie, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.026
Objective:
To investigate and compare the clinical efficacy of laparoscopic radical cystectomy and open surgery.
Methods:
100 patients with bladder cancer undergoing radical cystectomy admitted from January 2015 to July 2017 were randomly divided into two groups. Laparoscopic radical cystectomy was performed in patients with laparoscopic surgery, while patients in open group The patients were given open surgery. The clinical indexes, perioperative complications and quality of life were compared between the two groups.
Results:
The ASA score, intraoperative blood loss, intraoperative blood transfusion, anal exhaust time, dietary recovery time, pelvic drainage time and hospitalization time were significantly lower in the laparoscopic group than in the open group. The perioperative overall complication rate (P <0.05). The postoperative blood transfusion rate was significantly higher than that in the open group (P <0.05). There was a significant difference between the open group and the control group There was a significant difference between the two groups (P <0.05).
Conclusion:
Compared with open surgery, laparoscopic radical cystectomy has the advantages of low trauma, rapid recovery after operation, fewer complications and better long-term prognosis.
2018 Vol. 24 (5): 802-804 [
Abstract
] (
89
)
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(1294 KB) (
240
)
805
Clinical Effects of Neuroendoscopic Evacuation of Hematoma Via CT-guided Coronal Suture Anterior Approach
QU Zhe, WANG Dong, ZHANG Jinfeng, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.027
Objective:
To investigate the clinical effects of neuroendoscopic evacuation of hematoma via CT-guided coronal suture anterior approach.
Methods:
86 patients with hypertensive intracerebral hemorrhage (HICH) in our hospital from June 2015 to March 2017 were selected, and they were divided into two groups by random number table, 43 cases in each. Control group was given routine stereotactic vacuation of hematoma, observation group was given neuroendoscopic evacuation of hematoma via CT-guided coronal suture anterior approach. The surgical indexes, surgical effects, rebleeding rate, fatality rate and the incidence of complications of two groups were compared.
Results:
The surgical indexes of observation group were significantly better than those of control group, and the total surgical effective rate was significantly higher than control group, the rebleeding rate, fatality rate and the incidence of complications were significantly lower than control group (P<0.05).
Conclusion:
Neuroendoscopic evacuation of hematoma via CT-guided coronal suture anterior approach can effectively shorten surgery time and recovery time of hemiplegia, protect normal brain tissues, decrease surgical risks, reduce complications and death.
2018 Vol. 24 (5): 805-808 [
Abstract
] (
76
)
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(1 KB)
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(1307 KB) (
189
)
809
Relationship between Serum Metal Ions, Vitamin B
12
and Alzheimer Disease
SONG Lei, LI Hua, FU Yimin
DOI: 10.3969/j.issn.1006-6233.2018.05.028
Objective:
To explore the correlation between serum metal ions, vitamin B
12
and the pathogenesis of Alzheimer’s disease (AD).
Methods:
Forty-six patients who met AD diagnostic criteria were selected as AD group, and Forty-five elderly patients with normal cognitive function at the same time were selected as control group. The contents of Cu, Zn, Fe, Pb, Cd, Ca, Mg and Mn in the two groups were compared. Logistic regression analysis was used to analyze the correlation between 8 kinds of metal ions, vitamin B
12
and simple intelligent state scale (MMSE) score.
Results:
The concentration of copper ion in AD group was significantly higher than that in control group; Vitamin B
12
content was significantly lower than the control group, the difference was statistically significant (t = 3.477,5.102, all P <0.05). Logistic regression analysis showed that both copper ion, vitamin B
12
content and age all contributed to the independent risk factors of MMSE score decline in AD patients (χ
2
= -0.256, 4.527, -0.328, all P <0.05).
Conclusion:
The levels of copper ion and vitamin B
12
in elderly patients are related to AD, which are independent risk factors of AD.
2018 Vol. 24 (5): 809-811 [
Abstract
] (
79
)
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(1304 KB) (
337
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812
Effect of Comprehensive Behavioral Intervention on Delaying Disease Progression in patients with Chronic Obstructive Pulmonary Disease
QIN Qin
DOI: 10.3969/j.issn.1006-6233.2018.05.029
Objective:
To investigate the effects of comprehensive behavioral interventions on the progression of patients with chronic obstructive pulmonary disease (COPD).
Methods:
106 cases of COPD in our hospital from March 2015 to May 2017 were selected. If they received comprehensive behavioral intervention, they were divided into observation group and control group. The control group received conventional treatment only, while the observation group received comprehensive behavioral intervention on the basis of conventional treatment. The patients of two groups were received respiratory function assessment after 6 months, and their quality of life and the number of acute attacks of COPD were evaluated.
Results:
After 6 months' intervention, the FEV1, FEV1% and the number of acute attacks in the observation group were significantly better than those in the control group, the difference was statistically significant (P<0.05). In the observation group, the social psychological influence, activity, respiratory symptoms and total scores in the SGRQ assessment scale were significantly lower than those in the control group at 6 months. The difference was statistically significant (P<0.05).
Conclusion:
The implementation of comprehensive behavioral intervention in patients with COPD can effectively improve lung function and quality of life of patients with chronic obstructive pulmonary disease, help to delay the progression of patients' condition, and has a very positive effect on the control of disease progression. It is recommended for clinical application.
2018 Vol. 24 (5): 812-815 [
Abstract
] (
112
)
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(1 KB)
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(1309 KB) (
127
)
816
Effect of Salmeterol Combined with Montelukast Sodium on the Lung Function and serum NO ET IFN-γ Levels of Children with Bronchial Asthma
PANG Jun, HUANG Rui, WANG Yuan, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.030
Objective:
To study the effect of salmeterol combined with montelukast sodium on the lung function, Carbon monoxide(NO), Endothelin (ET), interferon-γ(IFN-γ) levels of children with bronchial asthma.
Methods:
120 patients of bronchial asthma who were treated from April 2014 to April 2015 in our hospital were selected as research objects. According to draw method,those patients were divided into salmeterol group 40 cases, 40 cases of the combined group and montelukast group in 40 cases. three groups were given routine treatment of bronchial antispasmodic, oxygen inhalation, antibiotics and glucocorticoids, aminophylline Sustained-release Tablets was given according to the situation of children. The Salmeterol group was treated with routine treatment combined with salmeterol. while the combined group was treated with Montelukast sodium combined with Salmeterol. montelukast sodium group was treated with montelukast sodium.Then the clinical effect, wheezing, wheezing, wet rales disappeared time, FEV1, FEV1/FVC, PEF, NO, ET, IFN- gamma levels were compared between two groups.
Results:
The total effective rate of combined group was significantly higher than that of the control group (P＜0.05); the disappearance time of wheezing, wheezing and rales were significantly shorter than those of the salmeterol and montelukast sodium group(P<0.05); FEV1,FEV1/FVC,PEF were significantly higher than those of the salmeterol and montelukast sodium group (P＜0.05); serum NO, ET levels were significantly lower than those of the salmeterol and montelukast sodium group(P＜0.05), IFN-γ was significantly higher than that of the salmeterol and montelukast sodium group(P＜0.05).
Conclusion:
The combination of two drugs in the treatment of children with bronchial asthma is superior to the treatment of Shah Mette Lo or montelukast sodium, which can significantly improve the lung function of children. It may be related to the effective regulation of serum NO, ET and IFN- gamma levels.
2018 Vol. 24 (5): 816-819 [
Abstract
] (
77
)
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(1 KB)
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(1297 KB) (
234
)
820
Clinical Study of Fibrinolytic Enzyme combined with Atorvastatin in the Treatment of Transient Ischemic Attack
LI Yu, JIANG Zongze
DOI: 10.3969/j.issn.1006-6233.2018.05.031
Objective:
To investigate the clinical efficacy of plasmin (Plm) combined with atorvastatin (ATV) on transient ischemic attack (TIA) and its impact on the hemorheology and serum matrix metalloproteinase - 9 (MMP-9), hypersensitivity C- reactive protein (hs-CRP) levels in patients.
Methods:
100 cases of TIA in our hospital from February 2015 to February 2017 were selected and divided into two groups by random number table. The control group (50 cases) was treated with ATV, and the observation group (50 cases) was additionally treated with Plm. The clinical efficacy, the changes of Hemorheology and serum MMP-9 and hs-CRP levels and the incidence of adverse reactions before and after treatment were recorded and compared between the two groups.
Results:
After 4 weeks of treatment, the total effective rate of the observation group was 94%, which was significantly higher than that of the control group (74%, P<0.05). Compared with before treatment, the values of high shear viscosity (HBV), whole blood low shear viscosity (LBV), plasma viscosity (SV) and red cell backlog (HCT) were significantly decreased in the two groups after 4 weeks of treatment (P<0.01), and the blood rheology indexes above the observation group were significantly lower than those of the control group (P<0.01). After two weeks of treatment, the serum levels of MMP-9 and hs-CRP were significantly decreased (P<0.01) in the 4 groups, and the decrease in the observation group was more significant (P<0.01). Compared with the control group (10%), the adverse reaction rate in the observation group was 6%, the difference was not statistically significant (P>0.05).
Conclusion:
The combination of fibrinolytic enzyme and atorvastatin in the treatment of transient ischemic attack can effectively relieve the symptoms and signs of the patients, improve the blood rheology and microcirculation of the body significantly, and the curative effect is better and safe and reliable.
2018 Vol. 24 (5): 820-822 [
Abstract
] (
107
)
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(1 KB)
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(1304 KB) (
131
)
823
Analysis on Microsurgical Treatment of Early Glottic Carcinoma with CO
2
Laser Laryngoscope
HUANG Ankun, ZHOU Xingqiang, DU Baowen
DOI: 10.3969/j.issn.1006-6233.2018.05.032
Objective:
To analyze the clinical effect of CO
2
laser laryngoscope microsurgical treatment of early glottic laryngeal cancer.
Methods:
28 cases of early glottic carcinoma with CO
2
laser laryngoscopy treated in our hospital in November ~2016 November 2014 were selected as the observation group. Meanwhile, 28 cases of early glottic laryngocarcinoma treated by open partial laryngectomy in our hospital in October October 2012 to 2014 were selected as control group. The quality of life score (QOL) and serum vascular endothelial growth factor (VEGF) in two groups before and after treatment were compared and analyzed. Meanwhile, the local recurrence rate and survival rate of two groups of patients with different TNM staging were compared.
Results:
Before treatment, there was no significant difference between the two groups in QOL score and VEGF level (P> 0.05). After treatment, the indexes in the control group were [(25.6833.68 ± 6.354.97) points and (442.46351) respectively. 63 ± 36.0834.67 ng / L]. After treatment, the QOL score and VEGF level in the observation group were (45.62 ± 8.34) and (204.81 ± 32.24ng/L, respectively] (T = -13.71716.41, 35.4186.51; P <0.05). The rate of local recurrence in the observation group was significantly lower than that in the control group, and the survival rate was higher than that of the control group, and the difference between the groups was statistically significant (P < 0.05).
Conclusion:
The use of CO
2
laryngoscope microsurgery in the treatment of patients with early glottic laryngeal cancer is helpful to improve the quality of life of patients with low recurrence rate and high safety and is worthy of clinical promotion.
2018 Vol. 24 (5): 823-825 [
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826
Efficacy and Safety of Percutaneous Transhepatic Choledochoscopy in the Treatment of Intrahepatic and Extrahepatic Bile Duct Stones
GONG Yiwei, OU Junjie, PENG Chengdong, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.033
Objective:
To investigate the efficacy and safety of percutaneous transhepatic choledochoscopy in the treatment of intrahepatic and extrahepatic bile duct stones.
Method:
The clinical data of 92 patients with intrahepatic and extrahepatic biliary calculi in our hospital were retrospectively analyzed. Among them, 32 cases underwent percutaneous transhepatic choledochoscopy (observation group), 60 cases underwent conventional common bile duct lithotomy and T tube drainage (control group). The clinical efficacy (stone clearance rate, postoperative stone recurrence rate), operative related indexes (operation time, intraoperative bleeding, incision length, postoperative exhaust time, fasting time, hospitalization time), postoperative rehabilitation indexes [alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (STB)], liver function indexes and postoperative complications were compared between the two groups.
Results:
There was no significant difference in stone removal rate and postoperative stone recurrence rate between the two groups (P > 0.05). The operation time, intraoperative bleeding, incision length, postoperative exhaust time and fasting time in the observation group were significantly lower than those in the control group (P<0.05). The postoperative ALT, AST and STB of the two groups were significantly lower than those before operation (P<0.05), but there was no significant difference between the two groups in liver function index (P>0.05). The incidence of complications in the observation group was lower than that in the control group, the difference was statistically significant (P<0.05).
Conclusion:
Percutaneous transhepatic choledochoscopy and traditional surgery are effective in the treatment of intrahepatic and extrahepatic bile duct stones, and can improve the liver function of patients. But the former has the advantages of minimally invasive, less trauma, rapid postoperative recovery, low incidence of complications, and has more clinical value.
2018 Vol. 24 (5): 826-829 [
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56
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830
Comparison of Bipolar Artificial Femoral Head Replacement and Total Hip Arthroplasty in the Treatment of Senile Femoral Neck Fracture
FAN Lei, LI Jie, ZHAO Dazhong
DOI: 10.3969/j.issn.1006-6233.2018.05.034
Objective:
To investigate and compare the efficacy of bipolar artificial femoral head replacement and total hip arthroplasty in the treatment of elderly femoral neck fracture.
Methods:
A total of 80 elderly patients with femoral neck fracture who were hospitalized from January 2015 to January 2016 were randomly divided into two groups. Patients in BFHR group received bipolar artificial femoral head replacement (BFHR) while patients in THR group received total hip arthroplasty Replacement surgery (THR) was performed to compare the clinical parameters of the two groups, hip function, long-term complications and hip joint prognosis.
Results:
The operation time, intraoperative blood loss, intraoperative blood transfusion, hospitalization and hospitalization costs in BFHR group were significantly lower than those in THR group. The Harris total score at the end of follow-up was significantly lower than that in THR group. The long-term complication rate (P<0.05). There was a significant difference between the two groups (P>0.05). The WOMAC score and OHS score in the final follow-up were significantly higher than those in the THR group (P<0.05).
Conclusion:
Both BFHR and THR can achieve significant clinical effect in a short period of time, but fewer THR complications and better long-term prognosis are the first choice for elderly patients with femoral neck fracture. However, BFHR has low trauma and moderate cost, Elderly patients in poor condition, with reference.
2018 Vol. 24 (5): 830-833 [
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51
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834
Short-term Effect and Safety of Automatic Hemorrhoid Ligation in the Treatment of Ⅲ or Ⅳ Mixed Hemorrhoids
DENG Bing, XU Yongqiang, LI Haijun, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.035
Objective:
To study the short-term effect and safety of automatic ligation in the treatment of Ⅲ or Ⅳ mixed hemorrhoids.
Methods:
116 cases of Ⅲ or Ⅳ mixed hemorrhoids patients in our hospital from June 2014 to August 2016 were randomly divided into the control group and the observation group, 58 cases in each group. The control group was treated by Milligan Morgan (M-M), while the observation group was treated with automatic ligation of hemorrhoids (RPH). The operation time, wound healing time, hospitalization time, postoperative VAS score, total effective rate and incidence of complications were compared between the two groups.
Results:
The total operative efficiency of observation group (93.10%) was significantly higher than that of the control group (77.59%) (P<0.001); the operation time, wound healing time, hospitalization time and postoperative VAS scores were significantly lower in the observation group than those of the control group (P<0.01); the incidence of complications of observation group (6.89%) was significantly lower than that of the control group (32.75%) (P<0.001).
Conclusion:
RPH is effective in the treatment of mixed hemorrhoids at stage Ⅲ and Ⅳ. It can promote wound healing, reduce postoperative pain and has high safety.
2018 Vol. 24 (5): 834-836 [
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75
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837
Clinical Efficacy of Methylprednisolone in the treatment of Pediatric Intractable Pneumonia Mycoplasma Pneumonia
ZHENG Na, SUN Daqing
DOI: 10.3969/j.issn.1006-6233.2018.05.036
Objective:
To investigate the clinical efficacy of methylprednisolone in the treatment of children with intractable pneumonia mycoplasma pneumonia.
Methods:
200 infants with refractory mycoplasma pneumoniae pneumonia admitted from January 2016 to October 2017 were randomly divided into two groups, the control group received azithromycin, and the observation group received methylprednisolone Group of children with clinical indicators, the overall effect of treatment, disease-related parameters and safety.
Results:
The cough onset time, cough disappearance time, antipyretic time, wet rales disappear time, wheezing disappearance time and hospitalization time in observation group were significantly lower than those in control group. The 2/3 shadow absorption rate Significantly higher than the control group; the total effective rate was significantly higher than the control group; after treatment, the white blood cell count was significantly higher than the control group, CRP, IL-4, IL-10, IL-17 and TGF- Significantly lower than the control group, there was a significant difference (P <0.05); two groups of children with adverse drug reaction rate was not significantly different (P> 0.05).
Conclusion:
The clinical efficacy of methylprednisolone in the treatment of pediatric intractable pneumonia mycoplasma pneumonia is significant and has reference value.
2018 Vol. 24 (5): 837-840 [
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77
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841
Analysis of the Influence Factors of Vascular Cognitive Impairment in Acute Cerebral Infarction Patients
ZHAO Jianguo
DOI: 10.3969/j.issn.1006-6233.2018.05.037
Objective:
To observe the risk factors of vascular cognitive impairment(VCI) in acute cerebral infarction patients.
Methods:
A total of 100 cases of acute cerebral infarction patients were divided into VCI group (64 cases) and non-VCI group (36 cases) according to the presence of VCI. Then single factor and multi-factor analysis were implemented in the VCI among acute cerebral infarction patients.
Result:
No statistical significance was observed in smoking, drinking and arterial fibrillation between the two groups (p>0.05); while the statistical significances were obtained in comparisons of carotid artherosclerosis, primary hypertension, leukoaraiosis, diabetes and serum Hcy level between groups (p<0.05). The multivariable Logistic regression model revealed that the serum Hcy level [OR=0.520,95%Cl:1.120~1.014,P=0.001], leukoaraiosis [OR=6.833,95%Cl:2.474~12.365,P=0.002], primary hypertension[OR=2.671,95%Cl:1.031~7.120,P=0.011], carotid artherosclerosis [OR=3.319,95%Cl:1.225~8.669,P=0.040] and diabetes [OR=7.131,95%Cl:2.029~19.322,P=0.001] were all closely related to the presence of VCI in acute cerebral infarction patients.
Conclusion:
For patients with acute cerebral infarction, theses conditions such as diabetes, carotid atherosclerosis, primary hypertension, leukoaraiosis, and serum Hcy concentration may be considered as a hint for cognitive dysfunction.
2018 Vol. 24 (5): 841-843 [
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58
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844
Short and Long-term Effect of Small Bone Window Through Lateral Fissure Island Approach in the treatment of Hypertensive Cerebral Hemorrhage Less than 6h
ZHANG Xiaofeng, YU Zhihu, ZHANG Mingwen, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.038
Objective:
To observe the short-term and long-term effect of small bone window by the lateral fissure island approach for hypertensive intracerebral hemorrhage onset <6 h.
Methods:
60 patients with basal ganglia hypertensive intracerebral hemorrhage were selected, and divided into the observation group and control group, 30 cases in both groups. The observation group was treated with small bone window through the lateral fissure island approach, and the control group was through the temporal lobe cortex. The hematoma removal, rebleeding rate, the GOS score at one month after surgery, the functional recovery (assessed by ADL scale)at one year after surgery were compared between two groups.
Result:
The success rate of hematoma evacuation in the observation group was 96.67%, which was significantly higher than 60.00% in the control group (P <0.05). The rebleeding rate was 13.33% in the control group and no recurrence in the observation group, the difference was not significant (P > 0.05). There was no significant difference in GOS prognosis between the two groups at one month after surgery (P > 0.05). The mortality rate of the observation group and the control group were both 3.33%, the difference was not statistically significant (P > 0.05). The proportion of ADL grade Ⅰ in the surviving patients of observation group was 48.28%, which was significantly higher than 24.14% in the control group (P < 0.05).
Conclusion:
The effect of the small bone window through the lateral fissure Island approach is better than that of the temporal cortex approach. The removal of hematoma is complete and the patient's long-term function is better.
2018 Vol. 24 (5): 844-847 [
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53
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848
Application of Serum CysC Level in the Diagnosis of Acute Heart Failure and Its Effect on Patient's Treatment Effectiveness
ZHAN Maoqin
DOI: 10.3969/j.issn.1006-6233.2018.05.039
Objective:
To explore the application of serum CysC level in the diagnosis of acute heart failure.
Methods:
70 patients with acute heart failure from February 2015 to May 2017 in our hospital, the patients in the study group, 70 healthy subjects were selected as control group, the study group were diagnosed by detection of serum CysC levels, observed and recorded in patients with clinical diagnosis with fault effect.
Results:
there was a positive correlation between heart failure and serum CysC level. The serum CysC level in the study group was significantly higher than that in the normal level (P < 0.05).
Conclusion:
the detection of serum CysC level in the diagnosis of acute heart failure is more accurate in clinical diagnosis. It is helpful to observe the change of the patient's condition and achieve higher clinical treatment efficiency, so it should be further applied in clinic.
2018 Vol. 24 (5): 848-850 [
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66
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854
Clinic Application of Bushen Huoxue Fang Combined with Intrauterine Infusion to Improve the Receptivity of Endometrium
LU Xiaoning, DANG Huimin, XI Wenyan, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.041
Objective:
To investigate the effect of Bushen Huoxue decoction combine with intrauterine infusion of G－CSF on infertile patients and study its possible mechanism.
Methods:
60 patients with low endometrial receptivity of kidney deficiency and blood stasis syndrome were randomly divided into Chinese medicine group (20 cases), perfusion group (20 cases), and Chinese medicine combined perfusion group (20 cases). The Chinese medicine group was treated with Bushen Huoxue Decoction. The perfusion group was treated by intrauterine infusion of recombinant human G CSF, and the Chinese medicine plus perfusion group was treated by combination of them. The changes of pregnancy rate, TCM syndrome score, endometrial thickness and echo score, uterine artery pulsation index (PI) and resistance index (RI) were observed before and after treatment.
Results:
The pregnancy rate after treatment was higher than that of traditional Chinese medicine plus perfusion group than that of traditional Chinese medicine group and perfusion group (P<0.05). TCM syndrome scores were compared before and after treatment, and the Chinese medicine group and Chinese medicine plus perfusion group had statistical significance (P < 0.01). After treatment, the thickness and echo score of endometrium in each group increased significantly, and the thickness of endometrium in the Chinese medicine plus perfusion group was significantly higher than that of the traditional Chinese medicine group and the perfusion group (P < 0.001). After treatment, the thickness and echo score of endometrium in each group increased significantly, and the thickness of endometrium in the Chinese medicine plus perfusion group was significantly higher than that of the traditional Chinese medicine group and the perfusion group (P < 0.001). The pulsatility index of uterine artery in Chinese herbal medicine plus perfusion group was significantly lower than that in traditional Chinese medicine group (P< 0.01). There was no significant difference in uterine artery resistance index between the three groups (P < 0.05).
Conclusion:
The combination of Bushen Huoxue Recipe and intrauterine intrauterine infusion of recombinant human G CSF to improve the endometrial receptivity is reliable, which embodies the synergistic effect of the combination of traditional Chinese and Western medicine, and deserves further study and clinical popularization.
2018 Vol. 24 (5): 854-858 [
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66
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865
Analysis of Comprehensive Nursing Effects of High Ligation of Great Saphenous Vein combined with Foam Sclerotherapy for Varicose Veins of Lower Extremities
ZHAO Shuling
DOI: 10.3969/j.issn.1006-6233.2018.05.044
Objective:
To analyze the clinical effects of comprehensive nursing in the treatment of patients with varicose veins of the lower limbs by high ligation of the great saphenous vein combined with foam sclerotherapy.
Methods:
A total of 68 patients with varicose veins of lower extremities admitted to Second Affiliated Hospital of Harbin Medical University from July 2016 to July 2017 were randomly selected. All patients were treated with high ligation of great saphenous vein and injection of foam sclerosing agent. At the same time, the patients were divided into 34 cases in the control group and the treatment group according to the random envelope method. The patients in the control group were treated with routine nursing, and the patients in the treatment group were treated with comprehensive nursing, that is, the nursing intervention was carried out before, during and after the operation on the basis of the control group, and the psychological nursing and discharge nursing were carried out. The clinical symptoms and signs score, incidence of complications and nursing satisfaction of the two groups were analyzed.
Results:
The patients in the treatment group were more satisfied with the nursing than the control group. The clinical symptoms and signs and complications of the treatment group were lower than those in the control group (P < 0.05).
Conclusion:
The combination of high saphenous vein ligation and foam sclerosing agent injection in the treatment of varicose veins in patients with comprehensive nursing care intervention can not only improve the clinical symptoms and signs, improve nursing satisfaction, but also reduce the incidence of complications, it is worthy of clinical application.
2018 Vol. 24 (5): 865-867 [
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48
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868
Effect of Skin Care on Patients with Advanced Malignant Tumor Accompanied by Low Protein Edema
LIANG Ying
DOI: 10.3969/j.issn.1006-6233.2018.05.045
Objective:
To study study and analyze the skin care effect of advanced malignant tumor with low protein edema, so as to get effective nursing methods, effectively avoid complications and infection.
Methods:
In this study, 40 patients with advanced malignant tumor with low protein edema were treated in our hospital from March 2016 to August 2017. The randomized digital table was used to divide into the control group and the observation group. The two groups were 20 cases. The control group was treated with routine nursing. The main risk factors of the observation group were analyzed, and the corresponding nursing measures were implemented. After 3 weeks of nursing, the pressure sores, survival, depression, anxiety and nursing satisfaction of the two groups were observed.
Results:
The incidence of bedsore in the study group was lower than that in the control group (χ
2
=4.329, P<0.05). After 1 weeks and 3 weeks of nursing, the KPS score and QOL score of the study group were significantly higher than those in the control group (t=2.954, 3.053, P<0.05). The scores of self rating Anxiety Scale and self rating depression scale of the study group were significantly lower than those of the control group (t=2.942, 2.487, P<0.05). On the whole, the degree of satisfaction of the patients in the study group was significantly better than that of the control group (z=-3.606, P<0.05), and the total satisfaction rate was significantly higher than that of the control group (χ
2
=5.714, P<0.05).
Conclusion:
In clinical treatment of malignant tumor with low protein edema, the targeted nursing measures can effectively reduce the pressure sore, improve the patient's survival and quality of life, at the same time, it can also relieve the anxiety and depression of the patients and improve the patient's nursing satisfaction.
2018 Vol. 24 (5): 868-872 [
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49
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873
Clinical Effect of Different Drugs Combined with Kalo Sodium in Treatment of Bronchiectasis with Hemoptysis
YANG Dexiang, YANG Li, WANG Feng, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.046
Objective:
To analyze the clinical effect of different drugs combined with kalo sodium in treatment of bronchiectasis with hemoptysis.
Methods:
A retrospective study was conducted on 60 patients with bronchiectasis with hemoptysis from January 2013 to December 2016. The 30 cases of patients were treated with phentolamine combined with cardosulfan sodium as the observation group. 30 cases of patients were treated with pituitrin combined with cardosulfan sodium as the control group. Comparison of two groups of patients with clinical efficacy, the average amount of bleeding and bleeding time, adverse reaction rate.
Results:
After treatment, there was no statistically significant difference in the total effective rate between the observation group and the control group (83.33% vs. 86.67%, P>0.05). The average blood loss (161.34±34.51vs. 155.22±34.23) and bleeding time (5.27±0.52vs. 5.38±0.51)d in the observation and control groups were not statistically different (P>0.05).The total adverse reaction rate of the observation group was significantly lower than that of the control group (20.00% vs.. 50.00% P<0.05).
Conclusion:
Phentolamine and pituitrin combined with cardulfonated sodium in the bronchiectasis with hemoptysis, can produce a good clinical efficacy, but phentolamine combined with cardulfonated sodium treatment of bronchiectasis with hemoptysis, which he reaction rate is low.
2018 Vol. 24 (5): 873-875 [
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60
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876
Application of Two-dimensional Speckle Tracking Imaging in the Diagnosis of Neonatal Asphyxia Myocardial Damage and its Correlation with Serum Troponin
LI Lizhen, CHEN Chengcai, LIANG Yanling, et al
DOI: 10.3969/j.issn.1006-6233.2018.05.047
Objective:
To explore the value of two-dimensional speckle tracking imaging (2D-STI) in early evaluation on myocardial injury of neonatal asphyxia.
Methods:
70 cases of healthy neonatal (control group) and 70 cases of asphyxia neonates (research group) were studied. The cardiac function was valued by the color Doppler ultrasonography, and the serum troponin levels were measured by the automated chemiluminescence analyzer.
Results:
There were a positive correlation between total left ventricular systolic global longitudinal strain (LV GLS) and left ventricular output (LVO) (p <0.01), and a negative correlation between LV GLS and serum troponin (cTnI) in the research group (p <0.01).
Conclusion:
2D-STI can quantitatively evaluate the myocardial injury and thus can be used to assess the cardiac function of neonatal asphyxia.
2018 Vol. 24 (5): 876-880 [
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45
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