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2018 Vol. 24, No. 11 Published: 2018-11-15 1761 Effects on Cell Viability of HUVECs Stimulated by Serum From Children with Coronary Artery Lesions of Kawasaki Disease via Regulating PAI-1 YU Lin, CHEN Mingqun, et al DOI: 10.3969/j.issn.1006-6233.2018.11.001 Objective: To investigate the effect and mechanism of serum from children with coronary artery lesions of Kawasaki disease on the viability of human umbilical vein endothelial cells (HUVECs) by regulating PAI-1. Methods: Fifty-two children with Kawasaki disease were collected, including 25 children with coronary artery injury, 27 children with non-coronary artery injury, and 21 children with healthy control group. Clinical data were collected to detect the high risk of KD-CALs and coagulation index, and serum samples were prepared. Human umbilical vein endothelial cells (HUVECs) were treated with serum for 24 hours. The expression of PAI-1 in HUVECs was detected by RT-qPCR and the cell viability was detected by CCK-8. Results: Platelet, white blood cell (WBC), erythrocyte sedimentation rate (ESR), prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) and fibrinogen degradation product (FDP) levels in children with Kawasaki disease complicated with coronary artery injury were significantly higher than those in the control group. Conclusion: Children with KD-CALs have significantly elevated levels of serum PAI-1 in a massive hypercoagulable state, and increased PAI-1 levels in HUVECs leading to the inhibition of viability of HUVECs. 2018 Vol. 24 (11): 1761-1764 [Abstract] ( 91 ) HTML (1 KB)  PDF (1357 KB)  ( 134 ) 1765 Changes of Platelet Mitochondrial Function in Asthmatic Patients LIU Huifang, MA Hongxia DOI: 10.3969/j.issn.1006-6233.2018.11.002 Objective: To investigate the changes of platelet mitochondrial function in asthmatic patients. Methods: 122 cases were diagnosed as acute episode of asthma from April 2016 to May 2017. According to the severity grading standard, they were divided into 4 groups, 45 cases of intermittent state (first grade), 23 cases of mild asthma (second grade), 30 cases of moderate asthma (third grade) and 24 cases of severe asthma (fourth grade). 44 cases of normal control group came from the physical examination center at same time. Platelet and platelet mitochondria were separated from blood samples. The ultrastructure of platelets was observed by transmission electron microscopy. The platelet mitochondrial membrane potential (MMP), cytochrome C oxidase (COX) activity and adenosine triphosphate (ATP) activity were detected and their differences were analyzed. Results: There were significant differences in platelet mitochondrial membrane potential (MMP), cytochrome C oxidase (COX) activity and adenosine triphosphate (ATP) between asthma group and normal group (P<0.05). The mitochondrial function (MMP, ATP, COX) of asthmatic patients with different severity was significantly different from that of normal control group (P<0.05). Conclusion: There are mitochondrial respiratory chain inhibition and impaired function in asthmatic patients. Mitochondrial damage and dysfunction may play an important role in the pathogenesis of asthma. 2018 Vol. 24 (11): 1765-1768 [Abstract] ( 78 ) HTML (1 KB)  PDF (1812 KB)  ( 298 ) 1769 Significance of Progesterone beta -hCG combined with CA125 in Threatened Abortion ZHANG Yan, et al DOI: 10.3969/j.issn.1006-6233.2018.11.003 Objective: To analyze the clinical value of progesterone, chorionic gonadin (β-hCG) and glycoprotein 125 (CA125) detection in patients with threatened abortion. Methods: 113 cases of threatened abortion admitted in our hospital from May 2015 to November 2016 were divided into 65 cases of threatened abortion continuing pregnancy group and 48 cases of inevitable abortion group according to pregnancy outcome. 53 normal pregnancies were selected at the same time. The levels of progesterone, beta-hCG and CA125 were measured by radioimmunoassay. The serum levels of progesterone, beta-hCG and CA125 in each group were observed and compared. The possible risk factors of threatened abortion were identified. The relationship between P, beta-hCG and CA125 and threatened abortion was analyzed by multiple logistic regression and ROC curve. Results: The levels of progesterone and beta-hCG in the inevitable abortion group were lower than those in the threatened abortion group and were lower than those in the normal pregnancy group (11.70 [1.26], (24.09 [3.19], (26.70 [4.20] mg / mL, (1879.53 [220.18], (6982.11 [876.10], (7035.96 [965.12] mU / ml. CA125 was higher in threatened abortion group than in continuing pregnancy group and higher than in normal pregnancy group (57.88 [8.96], (27.63 [3.41], (19.40 [2.76] U/mL. The difference was statistically significant (P<0.05). Logistic regression analysis showed that serum progesterone, beta -hCG and CA125 levels were independent factors influencing the occurrence of threatened abortion. ROC curve showed, area under progesterone curve was 0.723 (95%CI was 0.628~0.819), and the sensitivity and specificity were 0.406 and 0.761. The area under the β-hGG curve was 0.513 (95%CI was 0.406~0.620), and the sensitivity and specificity was 0.653 and 0.672. Area under curve of CA125 was 0.812 (95% CI 0.737~0.888), the sensitivity and specific degree was 0.782 and 0.567, the joint detection area under the curve was 0.857 (95% CI was 0.790~0.924), sensitive and specific degree was 0.663 and 0.716 respectively, the joint detection area under curve is significantly higher than individual indicators. Conclusions: Progesterone, beta-hCG and CA125 can objectively reflect the state of pregnancy, predict threatened abortion, improve clinical diagnosis, thus conducive to clinical treatment. 2018 Vol. 24 (11): 1769-1772 [Abstract] ( 69 ) HTML (1 KB)  PDF (1392 KB)  ( 154 ) 1773 Efficacy and Safety of Percutaneous Nephrolithotomy under Modified Valdi via Posture for Renal Calculi GU Yong, LIU Jianjun, LI Yong DOI: 10.3969/j.issn.1006-6233.2018.11.004 Objective: To investigate the efficacy and safety of percutaneous nephrolithotomy under improved valdi via posture for renal calculi. Methods: 154 patients with renal calculus admitted to our hospital from October 2016 to November 2017 were analyzed retrospectively. The subjects were control group and study group. The control group was prone position and the study group was modified valdi via position. The clinical efficacy, blood pressure and heart rate, surgical results and adverse reactions were compared between the two groups. Results: The clinical effect of modified valdi via posture in the study group was significantly better than that in the control group ( P<0.05 ). There was no significant difference in blood pressure and heart rate between the two groups before treatment ( P>0.05 ). After treatment, the blood pressure and heart rate in the study group were significantly lower than those in the control group ( P<0.05 ). The operation time, blood loss and blood transfusion rate of kidney stone patients in the study group were all lower than those in the control group (P<0.05 )), and the ambulation time in the study group was also significantly higher than that in the control group (P<0.05 ). After treatment, the wound infection, chest distress, dysphoria and pleura injury in the study group were significantly less than those in the control group ( P<0.05 ). Conclusion: Percutaneous nephrolithotomy in modified valdivia position can improve the clinical effect of renal calculi, stabilize blood pressure and heart rate, and reduce the complications of patients, safe and reliable, worthy of clinical promotion. 2018 Vol. 24 (11): 1773-1776 [Abstract] ( 99 ) HTML (1 KB)  PDF (1281 KB)  ( 149 ) 1777 Effect of New Dressing on the Curative Effect of Calcitonin and Leukocyte count in Patients with Orthopedic Infection ZHOU Qingjie, LIANG Yun DOI: 10.3969/j.issn.1006-6233.2018.11.005 Objective: To explore the effect of new dressing on the curative effect and calcitonin and white blood cell count in patients with orthopedic infection. Methods: From January 2017 to January 2018, 80 patients with orthopaedic infectious wounds were selected as the study subjects. 40 patients with orthopaedic infectious wounds were treated with traditional dry gauze dressing change as the control group, and 40 patients were treated with new dressing - silverion dressing change as the study group. The clinical efficacy, procalcitonin and leukocyte counts, cytoinflammatory factors, healing time, times of dressing change, hospitalization days and wound infection rate of the two groups were evaluated. Results: The clinical efficacy of the patients in the study group was significantly better than that in the control group (P<0.05). There was no significant difference in the level of calcitonin in the two groups before the treatment (P > 0.05). After treatment, the average calcitonin water in the two groups was decreased, and the level of calcitonin in the study group was more obvious, the difference was statistical significance (P<0.05); there was no significant difference in the leucocyte count level between the two groups before treatment (P > 0.05). After treatment, the leucocyte count level of the two groups decreased significantly, and the level of leukocyte count decreased more significantly in the study group (P<0.05); the two groups before treatment were statistically significant. There was no significant difference in the level of inflammatory factors (P>0.05). The improvement of inflammatory factors in the patients after treatment was significantly better than that in the control group (P<0.05). The healing time of the patients in the study group was significantly shorter than that of the control group, the number of replacement times was less than the control group, and the number of days in hospital was less than that of the control group. The infection rate of the control group and the wound surface was significantly lower than that of the control group, the difference was statistically significant (P<0.05). Conclusion: Compared with the traditional dry gauze dressing change, the new dressing change has better clinical effect and better therapeutic effect in the treatment of orthopedic infectious wounds. And it can improve the level of procalcitonin and leukocyte count and the levels of various cytokines, shorten the hospitalization time, reduce the number of dressing changes, reduce the rate of wound infection, and further protect the life and health of patients. It is worthy to be widely applied in clinical. 2018 Vol. 24 (11): 1777-1781 [Abstract] ( 90 ) HTML (1 KB)  PDF (1270 KB)  ( 164 ) 1782 Application of Etomidate Plasma Target controlled Infusion combined with Sevoflurane Anesthesia in Gynecologic Laparoscopy YANG Mei DOI: 10.3969/j.issn.1006-6233.2018.11.006 Objective: To explore the application of etomidate plasma target controlled infusion combined with sevoflurane anesthesia in gynecological laparoscopic surgery. Methods: From October 2016 to October 2017, 80 cases of patients undergoing elective gynecologic laparoscopic surgery were studied in our hospital. According to the simple random method, the patients were divided into control group and observation group. The control group was treated with propofol by plasma target controlled infusion, and the target controlled infusion of etomidate was used in the observation group. The changes of mean arterial pressure (MAP), heart rate (HR), cognitive function change, awakening period and adverse reaction were compared between the two groups. Results: At the time of T1 and T2, the MAP level of the control group was higher than that of T0 time (P<0.05). When T1, T2 and T3 time, the HR level of the control group was higher than that of the T0 time (P<0.05); there was no statistically significant difference between the observation group and the control group at the time of T0 (P<0.05). The respiratory recovery time, the time of eye opening and extubation in the observation group were significantly shorter than those in the control group (P<0.05). The restlessness score and OAAS score in the observation group were significantly lower than those in the control group (P<0.05). Compared with before anesthesia, MMSE scores were decreased after operation in the two groups (P<0.05); the patients in the observation group after 6h, 24h, 48h, MMSE score higher than the control group (P<0.05). The incidence of adverse reactions in the control group was 22.50%, the incidence of adverse reactions in the observation group was 7.50%, and the incidence of adverse reactions in the observation group was lower than that in the control group (P>0.05). Conclusion: Etomidate plasma target-controlled infusion combined with sevoflurane anesthesia can reduce the influence on circulatory system in patients undergoing gynecological laparoscopic surgery. Moreover, the postoperative anesthesia recovery of this surgical program is faster, less impact on cognitive function of patients, higher safety. 2018 Vol. 24 (11): 1782-1785 [Abstract] ( 77 ) HTML (1 KB)  PDF (1268 KB)  ( 194 ) 1790 Expression of β-catenin and ILK in Gallbladder Carcinoma and the Correlation with Clinicopathological Parameters XU Dan, et al DOI: 10.3969/j.issn.1006-6233.2018.11.008 Objective: To analyze the expression of β-catenin and ILK in gallbladder carcinoma and its correlation with clinicopathologic parameters. Methods: 75 cases of cholecystitis associated with cholecystitis from April 2013 to May 2016 were selected. According to the results of pathological examination, 47 cases were gallbladder carcinoma, 13 cases were cystic polyps, and 15 cases were chronic cholecystitis. The expression levels of β-catenin and ILK were measured. Results: The expression of ILK, β -catenin in gallbladder carcinoma was significantly higher than that in cystic polyps and chronic cholecystitis (P<0.05). The positive rates of ILK and β-catenin in patients with tumor diameter ≥ 2cm were higher than those in patients with tumor diameter < 2cm, and the difference of positive rate of β -catenin was statistically significant (P<0.05). The positive rates of ILK and β -catenin in patients with different pathological differentiation degrees were significantly different. The positive rates of ILK and β -catenin from high to low were high differentiation, middle differentiation and low differentiation. The positive rate of ILK and β -catenin in serous infiltration patients was higher than that in non-serous infiltration patients (P<0.05). The positive rate of ILK and β -catenin in patients with lymph node metastasis was significantly higher than that in patients without lymph node metastasis (P<0.05). There was a significant positive correlation between the positive rate of LLK and β -catenin in gallbladder carcinoma (P<0.05). Conclusion: The positive rates of β -catenin and ILK in gallbladder carcinoma tissues are significantly increased, and the increased expression level of β -catenin and ILK may indicate the increase of invasion and lymph node metastasis risk, and the expression of β -catenin and ILK is positively correlated with the expression of β -catenin in gallbladder carcinoma. 2018 Vol. 24 (11): 1790-1793 [Abstract] ( 71 ) HTML (1 KB)  PDF (1525 KB)  ( 136 ) 1794 Clinical Efficacy of Tabazole Combined with Glucocorticoid in the Treatment of Hyperthyroidism and Its Effect on Serum PC III beta 2-MG HA and ALB WANG Bo, et al DOI: 10.3969/j.issn.1006-6233.2018.11.009 Objective: To investigate the clinical efficacy of tabazole combined with glucocorticoid in the treatment of hyperthyroidism and its effect on serum procollagen type III (PCIII), beta 2-microglobulin (beta 2-MG), hyaluronic acid (HA) and albumin (ALB). Methods: 80 cases of hyperthyroidism according to simple random sampling were divided into control group and research group, 40 patients in each group. control group was treatmented with tumazole, and the research group was treatmented with tumazol and glucocorticoids. then clinical curative effect, thyroid-stimulating hormone (TSH), three free iodine thyroid glycine (FT3), free thyroxine (FT4), PCⅢ, β2-MG, HA, ALB, and adverse reactions occur between two group was compared. Results: The total effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P<0.05). TSH increased and FT3 and FT4 decreased in both groups at 3 and 6 months after treatment. TSH was higher and FT3 and FT4 were lower in the study group than in the control group at each time point. The thyroid levels of the two groups were significantly different at 3 and 6 months after treatment (P<0.05). At 3 and 6 months after treatment, PCIII, beta 2-MG and HA were decreased and ALB was increased in both groups. PCIII, beta 2-MG and HA in study group were lower than those in control group and ALB was higher than those in control group at each time point. The serum levels of PCIII, beta 2-MG, HA and ALB in two groups were significantly different at 3 months and 6 months after treatment (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Tabazole combined with glucocorticoids in the treatment of hyperthyroidism is superior to tabazole alone. It can reduce serum PC III, beta 2-MG and HA levels, promote the expression of ALB, may be an effective treatment for hyperthyroidism patients. 2018 Vol. 24 (11): 1794-1797 [Abstract] ( 79 ) HTML (1 KB)  PDF (1255 KB)  ( 146 ) 1798 Effect of Different Fluid Resuscitation Methods on treatment Efficacy and Immune Regulation Level in Patients with Traumatic Shock Accompanied by TIC YAN Xiaowei, LI Xiaodong, LI Suqing, et al DOI: 10.3969/j.issn.1006-6233.2018.11.010 Objective: To explore the clinical efficacy of damage control resuscitation (DCR) and active fluid resuscitation (AFR) in patients with traumatic shock and trauma induced coagulopathy (TIC). Methods: The clinical data of 92 patients with traumatic shock and TIC treated in our hospital from September 2011 to December 2017 were retrospectively analyzed. According to the fluid resuscitation strategy, the patients were divided into the amage control resuscitation group (DCR group, 47 cases) and active fluid resuscitation group (AFR group, 45 cases) . The activated partial thromboplastin time (APTT), international normalized ratio (INR), serum lactate (LAC), and hematocrit (HCT) in the two groups at 30 min before resuscitation and 6 h after resuscitation, and the two groups of shock index( SI), mean arterial pressure (MAP), blood pressure fluctuation amplitude, total fluid volume at 24 hours after resuscitation, platelet activating factor (PAF), Phospholipase A2 (PLA2) at 30min before resuscitation, 6h, 18h, and 36h after resuscitation, within 72h of recovery the complication rate and the survival rate at 1 week after resuscitation were compared. Results: There were no significant differences in MAP, SI, and injury severity score (ISS) between the two groups at admission (P>0.05). There was no significant difference in the APTT, INR, LAC, and HCT values between the two groups at 30 min before resuscitation (P>0.05); APTT, INR, LAC values were significantly lower,but HCT values were significantly higher in the DCR group than those in the AFR group at 6 hours after resuscitation (P<0.05). The MAP, blood pressure fluctuation amplitude, SI value, and total rehydration dose in the DCR group were significantly lower than those in the AFR group at 24 hours after resuscitation (P<0.05). There was no significant difference in PAF and PLA2 between the two groups at 30 minutes before and 18 hours after resuscitation (P>0.05). The PAF and PLA2 at 6 hours after resuscitation in the DCR group were significantly higher than those in the AFR group (P<0.05). The PAF and PLA2 at 36 hours after resuscitation were in the DCR group were significantly lower than those in the AFR group (P<0.05). After 72 hours of resuscitation, the incidence of ARDS, DIC, and MODS was significantly lower in the DCR group than in the AFR group, and the survival rate after one week of resuscitation was significantly higher in the DCR group than in the AFR group (P<0.05). Conclusion: Compared with AFR, DCR is effective in treating patients with traumatic shock and TIC, improving coagulation function, effectively correcting shock, stable blood pressure during resuscitation, low complication rate, high survival rate, and obvious clinical advantage; but in early resuscitation treatment AFR can effectively inhibit immunocytokines and inflammatory mediators and has a certain degree of immune regulation. 2018 Vol. 24 (11): 1798-1803 [Abstract] ( 81 ) HTML (1 KB)  PDF (1297 KB)  ( 153 ) 1804 Clinical Observation of Pectin-Bismuth Triple Therapy and Quadruple Therapy in the Treatment of Refractory Peptic Ulcer TAO Donghong, LIU Mingcheng DOI: 10.3969/j.issn.1006-6233.2018.11.011 Objective: To explore the clinical effect of colloidal bismuth pectin triple therapy and quadruple therapy in the treatment of refractory peptic ulcer and the influence on intestinal microflora, Helicobacter pylori (Hp) eradication rate and adverse reactions. Methods: 120 patients with refractory peptic ulcer admitted to our hospital from October 2017 to December 2017 were selected as the study subjects. All the patients were divided into control group and observation group by simple random grouping method, 60 cases in each group. The control group was treated with pectin bismuth triple therapy, while the observation group was treated with pectin bismuth quadruple therapy. The curative effect of the two groups was compared, the distribution of intestinal microflora was measured before and after treatment, the eradication rate of HP was counted, and the incidence of adverse reactions was observed. Results: The total effective rate of treatment in the observation group was higher than that in the control group (96.67% vs 86.67%) (P<0.05). Before treatment, there was no significant difference in intestinal microflora between the two groups (P>0.05). The amount of prevotella, lactobacillus, clostridium leptum, bacteroides fragilis and enterobacteriaceae in the observation group at 4 weeks after drug withdrawal was higher than that in the control group, while the amount of Clostridium was lower than that in the control group (P<0.05). The Hp eradication rate in observation group at 4 weeks after drug withdrawal was higher than that in control group (96.67% vs 85.00%) (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The total effective rate of colloidal bismuth pectin quadruple therapy is high in the treatment of refractory peptic ulcer, and the Hp eradication rate is also high. It can adjust the intestinal microecological balance with low incidence of adverse reactions, and it can be tolerated by patients. 2018 Vol. 24 (11): 1804-1807 [Abstract] ( 83 ) HTML (1 KB)  PDF (1255 KB)  ( 310 ) 1808 Effect of Transcranial Ultrasound combined with Rehabilitation Guidance on the Curative Effect and Prognosis of Patients with Cerebral Hemorrhage Tang Ying, Wei Feng'ou, Huang Dapeng, et al DOI: 10.3969/j.issn.1006-6233.2018.11.012 Objective: To explore the effect of transcranial ultrasound combined with rehabilitation guidance on the curative effect and prognosis of patients with cerebral hemorrhage. Methods: From February 2016 to February 2017, 68 cases of patients with cerebral hemorrhage treated in our hospital were selected as the subjects. According to simple random method, the patients were divided into two groups. The control group was given routine limb rehabilitation exercise, and the observation group was given routine limb rehabilitation exercise plus transcranial ultrasound treatment. Limb function recovery and life therapy score were compared between the two groups after 6 weeks of treatment, and after treatment Fugl-Meyer motor function, Barthel score, Hamilton depression scale (HAMD) score, Hamilton anxiety scale (HAMA) score. Results: The improvement rate of limb function in the observation group was better than that in the control group (52.95% VS 76.47%, P<0.05). After treatment, the Fugl-Meyer motor function and Barthel score of the two groups were higher than those before treatment (P<0.05), while the Fugl-Meyer motor function and Barthel score of the observation group were higher than those of the control group (P<0.05). After treatment, the scores of HAMD and HAMA in the two groups were lower than those before treatment (P<0.05), while the scores of HAMD and HAMA in the observation group were lower than those in the control group (P<0.05). The quality of life in the observation group after treatment for 6 weeks was higher than that in the control group (P<0.05). Conclusion: Transcranial ultrasound combined with rehabilitation guidance in the treatment of patients with cerebral hemorrhage. This treatment can effectively restore limb function and improve psychological status, improve the quality of life. It has important clinical significance. 2018 Vol. 24 (11): 1808-1811 [Abstract] ( 99 ) HTML (1 KB)  PDF (1271 KB)  ( 155 ) 1812 Effect of Sublingual Captopril on Emergency Treatment and Serum Levels of 8-isoPGF2 Alpha ox-LDL and PARK7 in Patients with Acute Ischemic Stroke SUN Baocun, et al DOI: 10.3969/j.issn.1006-6233.2018.11.013 Objective: To investigate the effect of sublingual captopril on emergency therapy of acute ischemic stroke and the effects of serum 8-Isoprostaglandin F2 alpha (8-isoPGF2 alpha), oxidized low-density lipoprotein (ox-LDL) and Parkinson's protein 7 (PARK7). Methods: 91 patients of acute ischemic stroke received treatment from February 2016 to February 2018 in our hospital were selected as research objects, according to the smiple random number table. All those patients were divided into the 46 cases of observation group and the 45 cases control group. The control group was given routine treatment, the observation group was given captopril tablets sublingual treatment on the basis of the control group. The two groups were treated continuously for 14d. The clinical efficacy, NIHSS score, Barthel index, blood lipid index, serum 8-isoPGF2a, ox-LDL and PARK7 were compared between the two groups. Results: After treatment, the total effective rate of the observation group was 91.30% (42/46), which was significantly higher than that of the control group 73.33% (33/45) (P<0.05). Compared with those before treatment, the NIHSS score and Barthel index of the two groups improved significantly after treatment (P<0.05), the NIHSS score in the observation group was significantly lower than that of the control group, and the Barthel index was significantly higher than that of the control group (P<0.05). Compared with those before treatment, the blood lipid indexes of the two groups were significantly improved after treatment (P<0.05), the total cholesterol (TC), three glycerol (TG) and low density lipoprotein cholesterol (LDL-L) in the observation group were significantly lower than that of the control group, and the high density lipoprotein cholesterol (HDL-C) was significantly higher than that of the control group (P<0.05). After treatment, the serum 8-isoPGF2α, ox-LDL and PARK7 levels in the two groups were significantly lower than those before treatment (P<0.05), and the serum levels of 8-isoPGF2α, ox-LDL and PARK7 in the observation group were significantly lower than that of the control group [(352.30±32.01)μg/dl VS (398.45±39.45)μg/dl, (7.30±1.24)pg/mL VS(9.94±1.75)pg/mL,(19.42±2.32)μg/L VS(25.87±2.95)μg/L](P<0.05). There were no severe adverse reactions during the two groups, no cerebral hemorrhage patients, 2 patients in the observation group had rash and itching, and no special treatment was needed after the drug was stopped. Conclusion: The effect of sublingual captopril in the treatment of acute ischemic stroke is remarkable. It is helpful to improve nerve function. The internal mechanism may be related to reducing the expression of serum 8-isoPGF2 alpha, ox-LDL, PARK7 and alleviating oxidative stress. 2018 Vol. 24 (11): 1812-1816 [Abstract] ( 72 ) HTML (1 KB)  PDF (1299 KB)  ( 168 ) 1817 Comparison of MRI and Spiral CT in Preoperative Staging of Rectal Cancer PANG Jichao, WANG Pinghuai DOI: 10.3969/j.issn.1006-6233.2018.11.014 Objective: To investigate the clinical application value of MRI and spiral CT in the preoperative staging diagnosis of rectal cancer, and to provide the effective basis for the clinical assessment of rectal cancer. Methods: 50 patients with rectal cancer treated in our hospital from January 2014 to December 2015 were selected. The T staging clinical examination rate, lymph node diagnosis accuracy and internal organ structure lesions of the two groups were observed. Results: Compared with the statistics of T staging clinical examination rate of the two groups, the overall accuracy of MRI in the diagnosis of preoperative T staging of rectal cancer was significantly higher than that of spiral CT (T=3.07, P=0.01). The overall accuracy of MRI in diagnosis of lymph node lesions in preoperative t-staging of rectal cancer was significantly better than that of spiral CT(T=3.46, P=0.03). Conclusion: For preoperative staging and lymph node diagnosis of rectal cancer, MRI scan has a rapid, effective, high resolution and good specificity of clinical results. And it has a high clinical value. 2018 Vol. 24 (11): 1817-1820 [Abstract] ( 90 ) HTML (1 KB)  PDF (1724 KB)  ( 161 ) 1821 Application of Pulsed Wave Indicating Continuous Cardiac Output Monitoring (PICCO) Technique in Liquid Resuscitation of Multiple Trauma Patients LI Qiang, ZHANG Shupei, et al DOI: 10.3969/j.issn.1006-6233.2018.11.015 Objective: To investigate the application of Pulsed Wave Indicating Continuous Cardiac Output Monitoring (PICCO) technology in fluid resuscitation from multiple trauma patients. Methods: 80 patients with multiple traumatic fluid resuscitation who were admitted from March 2017 to March 2018 were randomly divided into two groups. Patients in the control group were given traditional TTE and CVP monitoring. Patients in the PICCO group were treated with PICCO. The life related evidence and clinical observation index of the two groups during the monitoring period were compared. Results:The HR, CVP, MAP, CI, GEF, GEDVI, ITBVI, EVLWI, LAC, and APACHEII scores in the PICCO group were significantly lower than those in the control group at the time of T2 and T3, and the PaO2/FiO2 levels were significantly higher than those in the control group. The control group; 72h liquid volume, ventilator time, norepinephrine use, ICU time and mortality at 28 days were significantly lower than the control group, the difference was statistically significant (P<0.05). Conclusion:The application of pulse wave indication continuous cardiac output monitoring technique in fluid resuscitation of patients with multiple trauma is significant and has reference significance. 2018 Vol. 24 (11): 1821-1823 [Abstract] ( 74 ) HTML (1 KB)  PDF (1254 KB)  ( 256 ) 1824 Diagnostic Value of Ankle-brachial Index Combined with Vibrating Perception Threshold in Type 2 Diabetes Mellitus Complicated with Lower Extremity Atherosclerotic Disease LUO Lingguang, LONG Xinping DOI: 10.3969/j.issn.1006-6233.2018.11.016 Objective: To explore the diagnostic value of ankle brachial index (ABI) combined with vibration perception threshold (VPT) in type 2 diabetes mellitus (DM) complicated with lower extremity atherosclerotic disease. Methods: A total of 119 type 2 diabetes mellitus patients with PAD were selected and randomly divided into two control group (ABI≥0.9; VPT≤10 V) 56 cases and observation group (ABI<0.9; VPT>10V) 63 cases. The ABI was detected by ultrasonic flow meter, and The VPT was detected by digital vibration perception threshold detector,and the levels of TC, TG, HDL-C, LDL-C, FBG, HbA1c, uric acid and ALB were detected by automatic biochemical analyzer. Results: The level of ABI in the observation group was lower than that in the control group, and the VPT level was higher in the observation group than that in the control group (t=13.45, 14.67, P<0.05); The level of LDL-C in the observation group was higher than that in the control group (t=15.32, P<0.05); The level of uric acid in the observation group was higher than that in the control group (t=15.67, P<0.05); The age, course of disease, LDL-C and uric acid were negatively correlated with ABI and positively correlated with VPT, with statistic difference (P<0.05); Age, duration of disease, LDL-C, and uric acid were risk factors for type 2 diabetes mellitus with LEAD (regression coefficients =1.43, 1.61, 1.71, 1.45, P<0.05);ABI ≤ 0.9 is the gold standard for the diagnosis of type 2 diabetes mellitus combined with lower extremity atherosclerotic disease. The diagnostic criteria are VPT>10 V, sensitivity is 75.9%, specificity is 84.8%, false negative rate is 24.0%, false positive rate 15.2%, correct index 0.61, positive likelihood ratio 4.99, negative likelihood ratio 0.28, Kappa consistency analysis, value is 0.60. Conclusion: In type 2 diabetic patients with lower extremity atherosclerotic disease, ankle brachial index decreased and vibration perception threshold increased, which were closely related to the risk factors such as age, course of disease, LDL-C, uric acid. 2018 Vol. 24 (11): 1824-1828 [Abstract] ( 70 ) HTML (1 KB)  PDF (1289 KB)  ( 187 ) 1829 Curative Efficacy of Hyperbaric Oxygen combined with Thiocic Acid Injection in treatment of Diabetic Foot and its Effects on Angiogenesis Factors HAN Mei, SU Junping, LIU Xinrong, et al DOI: 10.3969/j.issn.1006-6233.2018.11.017 Objective: To investigate the clinical effect of hyperbaric oxygen combined with lipoic acid injection on diabetic foot. Methods: 85 cases of diabetic foot patients admitted to our hospital from May 2015 to May 2017 were selected as the study subjects, the randomization method was divided into the observation group (n=45) and the control group (n=40), the control group was treated with thiocyanic acid injection, and the observation group was treated with hyperbaric oxygen combined with thiocyanic acid injection. After treatment, the efficacy and serum endothelin (ET), calcitonin gene-related peptide (CGRP), endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) levels, hemorheology and HbAlc values were compared between the two groups. Results: After treatment, the total effective rate of the observation group was 93.33% higher than that of the control group (P<0.05). There was no significant difference in ET, CGRP, VEGF and bFGF levels between the two groups before treatment. After treatment, two groups of CGRP, VEGF and bFGF levels were significantly elevated, ET level declined obviously, observation group of CGRP, VEGF and bFGF were significantly higher than that of control group, ET level is significantly lower than control group (P<0.05); There was no significant difference in total blood viscosity, plasma viscosity and fibrinogen level between the two groups before treatment. After treatment, two groups of whole blood low shear viscosity, plasma viscosity and fibrin raw water average declined obviously, observation group whole blood low shear viscosity, plasma viscosity and fibrinogen were significantly lower than the control group, (P<0.05); Before treatment, there was no significant difference in HbAlc level between the two groups (P>0.05). After treatment, the HbAlc level of both groups decreased significantly, and the HbAlc level of the observation group was significantly lower than that of the control group (P<0.05). Conclusion: In diabetic foot patients, hyperbaric oxygen combined with thioic acid injection has a significant effect, and can effectively improve the serum ET, CGRP, VEGF and bFGF levels of patients, which is worthy of promotion and application. 2018 Vol. 24 (11): 1829-1832 [Abstract] ( 74 ) HTML (1 KB)  PDF (1275 KB)  ( 264 ) 1833 Effect of Carboprost Tromethamine combined with Oxytocin on Postpartum Hemorrhage after Cesarean Section and its Influence on Oxidative Stress and Coagulation Function HAN Huihui, FENG Chong, HEI Jiangrong DOI: 10.3969/j.issn.1006-6233.2018.11.018 Objective: To study the effect of carboprost tromethamine combined with oxytocin on postpartum hemorrhage after cesarean section and effects on, and oxidative stress and coagulation function. Methods: 130 patients of cesarean section who received therapy from December 2014 to December 2017 in our hospital were selected as research objects, according to random number table, those patients were divided into the observation group (n=65) and the control group (n=65), after the birth of the fetus, the control group was treated with oxytocin, while the observation group was combined with Carboprost Tromethamine. The postpartum hemorrhage, duration of uterine contraction, duration of uterine fundus, lochia duration, stress index, coagulation function and adverse reaction were compared between the two groups. Results: The bleeding volume of 2h and 24h in the observation group was significantly less than that of the control group, the postpartum hemorrhage rate in the observation group was 6.15% (4/65), which was also significantly lower than that in the control group 18.46% (12/65) (P<0.05); the observation group had longer uterine contraction, faster descending rate of uterine fundus, and shorter duration of lochia, compared with the control group, there were significant differences (P<0.05); at the end of operation and at after operation 24h, the malondialdehyde (MDA) in the observation group was significantly lower than that of the control group, and superoxide dismutase (SOD), glutathione peroxidase (GSH-px) and catalase (CAT) were significantly higher than that of the control group(P<0.05); at the end of operation and at after operation 24h, the fibrinogen (FBI), D- two polymer (D-D) in the observation group was significantly lower than that of the control group (P<0.05); there were no significant differences in facial flushing, nausea, vomiting, headache and chest tightness between the two groups(P>0.05). Conclusion: Carboprost tromethamine combined with oxytocin is well for prevention of postpartum hemorrhage in caesarean section, it's helpful for relieving perioperative stress reaction and improve blood coagulation function, and has high safety, it's worthy of application and promotion. 2018 Vol. 24 (11): 1833-1837 [Abstract] ( 75 ) HTML (1 KB)  PDF (1266 KB)  ( 259 ) 1838 Relationship between Chlamydia Pneumoniae Antibody IgG and IgM and Unstable Angina Pectoris GAO Li, JIANG Zhihui DOI: 10.3969/j.issn.1006-6233.2018.11.019 Objective: To study the relationship between immunoglobulin G (IgG) and immunoglobulin M (IgM) of Chlamydia pneumoniae (Cpn) antibody and unstable angina pectoris (UAP). Methods: 56 patients with UAP admitted to our hospital from March 2017 to March 2018 were selected as the study group and 30 healthy volunteers as the control group. The levels of plasminogen activator inhibitor-1 (PAI-1), C-reactive protein (CRP), tumor necrosis factor-1 (TNF-1), Cpn antibody IgG and IgM were compared between the two groups. The levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), TNF-α, CRP and PAI-1 were compared between the IgG positive group and the negative group. Results: The levels of PAI-1, CRP and TNF-α in the study group were significantly increased in comparison of those in the control group (P<0.05). There was no significant difference in the positive rate of Cpn antibody IgM between the two groups (P>0.05), but the positive rate of Cpn antibody IgG in the study group was significantly increased in comparison of the control group (P<0.05). The levels of TC, TG, LDL-C, TNF-α, CRP and PAI-1 in the positive group were significantly higher than those in the negative group (P<0.05), but there was no significant difference between the two groups of HDL-C levels (P>0.05). Conclusion: Cpn antibody IgG is closely related to the occurrence of UAP, and the mechanism may lie in the IgG of Cpn antibody can induce the release of inflammatory factors, and then induce the production of TNF-α and CRP, which may affect the lipid metabolism of plasma and cause UAP. 2018 Vol. 24 (11): 1838-1840 [Abstract] ( 88 ) HTML (1 KB)  PDF (1260 KB)  ( 170 ) 1841 Clinical Efficacy of of Magnesium Sulfate Combined with Xueyaping Granules on Pregnancy-induced Hypertension and Effects on the levels of LIF, Apelin and Beta-HCG in Serum FENG Xiaoling, WANG He, WEI Hongfa DOI: 10.3969/j.issn.1006-6233.2018.11.020 Objective: To evaluate the clinical efficacy of magnesium sulfate combined with Xueyaping granules in the treatment of pregnancy-induced hypertension (PIH), and the effect on serum leukemia inhibitory factor (LIF) Apelin and β-chorionic gonadotropin (β-HCG) levels. Methods: 90 patients with PIH were enrolled of our hospital from December 2015 to December 2016. They were randomly divided into control group and experimental group (n=45). In the control group, 45 cases were treated with intravenous infusion of magnesium sulfate and lapelol hydrochloride tablets. 45 cases in the experimental group were treated with Xueyaping granules. Changes of serum LIF, Apelin and β-HCG levels were compared between the two groups. Changes of systolic and diastolic blood pressure before and after treatment were observed, and the pregnancy outcomes of different treatment groups were observed. Results: The total effective rate (88.89%) in the experimental group was higher than that in the control group (64.44%), the difference was statistically significant (P<0.05). There was no significant difference in LIF, Apelin and β-HCG levels between the two groups (P>0.05). After treatment, the levels of LIF were significantly increased, and the level of LIF, Apelin and β-HCG was significantly higher than that of the control group (752.38 ± 31.57 VS 703.01±32.02 (P<0.05). Apelin and β-HCG levels were significantly decreased, and the level of the experimental group was lower than that of the control group (233.33 ± 23.56 VS 271.69 ± 24.83), the difference was statistically significant (P<0.05) (15772.96 ± 1705.93) VS (11473.19 ± 1698.87)], the difference was statistically significant (P<0.05). The systolic and diastolic blood pressure of the experimental group were lower than those of the normal group (135.8 ± 6.9) VS (153.1 ± 8.7), and the systolic and diastolic blood pressure (88.0 ± 5.8) VS (92.97 ± 5.7)], the difference was statistically significant (P<0.05). Compared with the control group (35.56%), the difference between the two groups was statistically significant (P<0.05). Conclusion: Xueyaping granule combined with Magnesium Sulfate treatment for patients with PIH certain effect, can increase the level of LIF, serum Apelin and beta -HCG level, reduce the level of blood pressure and improve the outcome of pregnancy. 2018 Vol. 24 (11): 1841-1844 [Abstract] ( 86 ) HTML (1 KB)  PDF (1279 KB)  ( 179 ) 1845 Effect of Amlodipine on Blood Pressure and Vascular Endothelial Cell Function in Patients with Isolated Systolic Hypertension CHENG Ke, HAN Yuan, LIU Wenjun, et al DOI: 10.3969/j.issn.1006-6233.2018.11.021 Objective: To analyze the antihypertensive effect of amlodipine in treatment isolated systolic hypertension and its influences on endothelial cell function. Methods: 92 patients with isolated systolic hypertension who were treated from October 2016 to December 2017 in our hospital were divided into the control group (treated with enalapril) and observation group (treated with amlodipine) according to the simple random number table method with 46 cases in each group. The clinical efficacy, blood pressure changes, vascular endothelial cell function, and adverse reactions in both group were compared. Results: Total effective rate in the observation group was significantly higher than the control group, there was statistical differences (P<0.05). Before treatment, daytime systolic blood pressure (dSBP), average nighttime systolic blood pressure (nSBP) and 24h average systolic blood pressure (24SBP) in both groups were not statistically significant (P>0.05). After treatment of 4 weeks and 6 weeks, dSBP,nSBP,24hSBP in both group were declined, while the observation group decreased more obviously. There was statistically significant differences(P<0.05). Before treatment, the nitric oxide (NO), endothelin-1 (ET-1) and brachial artery flow-mediated vasodilation (FMD) in both groups were no differences. But after treatment of 4 weeks and 6 weeks, NO and FMD in both groups were all rised, ET-1 was decreased, while the observation group changed was more obvious. There was statistically significant differences (P<0.05). Adverse reaction rate in both groups were not statistically significant (P>0.05). Conclusion: Antihypertensive effect is better of amlodipine in treatment isolated systolic hypertension, and it can improve the function of vascular endothelial cells, which can provide reference for clinical blood pressure reduction. 2018 Vol. 24 (11): 1845-1848 [Abstract] ( 66 ) HTML (1 KB)  PDF (1274 KB)  ( 221 ) 1849 Clinical Efficacy of Mecobalamin Combined with Norfloxacin in the treatment of Gestational Diabetes Mellitus and its Effect on Serum RBP4 FGF21 and Nesfatin-1 FAN Xiaojun, WANG Jing DOI: 10.3969/j.issn.1006-6233.2018.11.022 Objective: To study curative efficacy of mecobalamin combined with insulin aspart flexpen in treatment of gestational diabetes mellitus and effects on serum retinol-binding protein 4(RBP4), fibroblast growth factor 21(FGF21), feeding inhibition factor -1(Nesfatin-1) levels. Methods: 100 patients of gestational diabetes mellitus who received therapy from October 2016 to October 2017 in our hospital were selected as research objects. According to random number table, all the patients were divided into the observation group (n=50) and the control group (n=50). The control group was treated with insulin aspart flexpen, while the observation group was combined with mecobalamin, they were treated with 7d for 1 courses, continuous treatment for 3 courses. Results: After treatment, fasting blood glucose (FPG) and 2-hour postprandial blood glucose (2-hour PBG) in both groups were significantly lower than those before treatment (P<0.05); FBG and 2-hour PBG in observation group were significantly lower than those in control group (P<0.05). After treatment, the levels of RBP4, FGF21 and Nesfatin-1 in serum of the two groups were significantly lower than those before treatment (P<0.05). The levels of RBP4, FGF21 and Nesfatin-1 in the observation group were significantly lower than those in the control group [(21.20+2.47) ug/mL VS (26.94+3.24) ug/mL, (101.39+13.52) ng/L VS (127.34+14.50) ng/L, (1.38+0.20) ug/L VS (1.67+0.27). G/L] (P<0.05); The total incidence of hypoglycemia, nausea, vomiting and hyperosmotic coma in the observation group was 8.00% (4/50), significantly lower than that in the control group (24.00% (12/50) (P<0.05). Conclusion: Mecobalamin combined with norfloxacin has significant therapeutic effect on gestational diabetes mellitus. It can effectively reduce blood glucose and the expression of RBP4, FGF21 and Nesfatin-1 in serum, and improve the adverse maternal and infant outcomes. It is safe to use Mecobalamin combined with norfloxacin. 2018 Vol. 24 (11): 1849-1852 [Abstract] ( 68 ) HTML (1 KB)  PDF (1269 KB)  ( 203 ) 1853 Application of Comprehensive Exercise Training in Knee Joint Replacement and its Effect on Joint Mobility and Function CHANG Liang DOI: 10.3969/j.issn.1006-6233.2018.11.023 Objective: To study application of comprehensive exercise training in knee joint replacement and its effect on joint mobility and function. Methods: 80 patients with comprehensive exercise training who received therapy from August 2014 to August 2016 in our hospital were selected. According to simple random number table, those patients were divided into the observation group (n=45) and the control group (n=45). After surgery, the control group was given simple passive training, the observation group was given comprehensive exercise training on the basis of the control group. After 1 month, treatment effect were compared between the two groups. Results: After surgery, the tibial angle, the knee joint line height and the maximum extension angle of the knee joint of tow groups were reduced, The maximum flexion angle of the knee joint and posterior tibial angle were increased(P<0.05), and the result of observation group was better than that of control group(P<0.05); the HSS score in the observation group was higher than that of the control group (90.85±2.17)scores VS(78.34±3.03)scores, the VAS score was lower than that of the control group (2.78±0.42)scores VS(4.59±0.53)scores(P<0.05);the total effective rate in the observation group was higher than that of the control group 93.33%(42/45) VS 75.56% (34/45)(P<0.05); the incidence rate of complication in observation group was lower than that in control group 2.22%(1/45)VS15.56(7/45)(P<0.05). Conclusion: The application of comprehensive exercise training after knee replacement can promote the recovery of joint mobility and function, reduce complications and improve prognosis. It is worthy of application and popularization. 2018 Vol. 24 (11): 1853-1856 [Abstract] ( 74 ) HTML (1 KB)  PDF (1276 KB)  ( 187 ) 1857 Comparison of Efficacy and Safety of Tegacycline combined with Xuebijing and Cefoperazone Sulbactam in the treatment of Carbapenem-resistant Acinetobacter Baumannii Infection MA Xin, ZHENG Jingjing, ZHANG Jie, et al DOI: 10.3969/j.issn.1006-6233.2018.11.024 Objective: To investigate investigate the efficacy and safety of tigacycline combined with Xuebijing and cefoperazone sulbactam in the treatment of carbapenem-resistant Acinetobacter baumannii infection. Methods: From February 2016 to February 2017, 92 patients with carbapenem-resistant Acinetobacter baumannii pneumonia were randomly divided into study group (n = 46) and control group (n = 46). Patients in the study group were treated with tegacycline combined with Xuebijing, while patients in the control group were treated with tegacycline combined with cefoperazone sulbactam. The clinical efficacy, bacterial clearance rate, inflammatory response related indicators [C-reactive protein (CRP), white blood cell count (WBC), procalcitonin (PCT)], disease development and adverse reactions were compared between the two groups. Results: The total effective rate and bacterial eradication rate in research group were 91.30% and 78.26%, which were higher than 71.74% and 58.70% in control group (P<0.05); After treatment, the CRP, WBC, PCT levels, CPIS and APACHE II scores in research group were lower than those before treatment and control group (P<0.05); The total incidence of adverse reactions in research group was 6.52%, which was lower than 21.74% in control group (P<0.05); After treatment, the levels of BUN and Scr in control group were higher than those in research group (P<0.05). Conclusion: Tigecycline cobined with Xuebijing in treatment of carbapenem-resistant Acinetobacter baumannii is effective. It can increase the bacterial eradication rate, reduce inflammatory response and have high safety, which has better curative effects compared with tigecycline cobined with cefoperazone-sulbactam. 2018 Vol. 24 (11): 1857-1861 [Abstract] ( 73 ) HTML (1 KB)  PDF (1288 KB)  ( 174 ) 1862 Effect of Laparoscopic Gastric Perforation Repair on Gastric Oerforation and its Influence on the Electrogastrogram Parameters ZHOU Sheng, WANG Linquan, ZHAO Xudong DOI: 10.3969/j.issn.1006-6233.2018.11.025 Objective: To investigate the clinical efficacy of laparoscopic gastric perforation repair on gastric perforation and its influence on the electrogastrogram parameters. Methods: From May 2015 to June 2017, 122 patients with gastric perforation were divided into laparoscopic group and open group according to different surgical methods. 68 patients in laparoscopic group underwent laparoscopic gastric perforation repair and 54 patients in open group underwent open gastric perforation repair. The clinical efficacy, changes of electrogastrogram parameters as well as serum PGI, AMY, GAS,MTL levels before and after operation were compared between the two groups. Results: Intraoperative blood loss of laparoscope group significantly lower than open group, bowel sound recovery time, exhaust time and length of stay significantly shorter than open group did (P<0.01). The percentage of normal slow wave rhythm, gastric electrical amplitude, gastric electrical frequency, and gastric electrical dominant power of laparoscope group after operation at different time points were all higher than those of open group after operation at the identical time points (P<0.01). The PGI level of laparoscope group 7d after operation was significantly higher than that of open group at the identical time point, the AMY level of laparoscope group 3, 7d after operation was significantly lower than that of open group at the identical time point, and the GAS, MTL levels of laparoscope group 1,3, 7d after operation were significantly lower than those of open group at the identical time point (P<0.01). The incidence of complication in the laparoscopic group was significantly lower in the open group (7.35% vs 27.78% P<0.01). Conclusion: In treating gastric perforation, laparoscopic gastric perforation repair has minor trauma, quicker recovery, less influence on electrogastrogram parameters and serum digestible indexes, and promotes the recovery of gastroenteric function. 2018 Vol. 24 (11): 1862-1866 [Abstract] ( 68 ) HTML (1 KB)  PDF (1264 KB)  ( 166 ) 1867 Efficacy and Complications of Levocarnitine Recombinant Human Erythropoietin and Iron in Hemodialysis Patients DONG Haixia, LV Yufeng DOI: 10.3969/j.issn.1006-6233.2018.11.026 Objective: To analyze the effects of combined treatment with L-carnitine, recombinant human erythropoietin and iron on the clinical efficacy and complications of hemodialysis patients. Methods: 92 hemodialysis patients who were admitted to our hospital from May 2017 to May 2018 were selected and randomly divided into control group (n=46) and observation group (n=46) according to the random number table method; Recombinant human erythropoietin and iron were only given. Patients in the observation group were treated with levocarnitine, recombinant human erythropoietin, and iron; clinical efficacy was compared between the two groups. Results: After treatment, the incidence of complications in the observation group and the control group were 2.17% (1/46) and 15.22% (7/46), respectively. The difference between the two groups was statistically significant (χ2= 4.929, P<0.05). Before treatment, there was no significant difference in iron transgenic protein saturation, hematocrit, serum ferritin and hemoglobin between the two groups (P>0.05). The levels of the indicators in the observation group were compared with the control group. The differences between the two groups after treatment were compared, and the differences in improvement were not compared. There were significant differences between the two groups (t=7.107, 12.581, 38.529, 12.024; P<0.05); The levels of blood urea nitrogen, blood urea and serum creatinine were significantly lower in the patients after treatment than in the control group (t=8.855, 18.612, 37.383; P<0.05). Conclusion: The combination of levocarnitine, recombinant human erythropoietin, and iron in patients with hemodialysis complications can effectively improve the clinical symptoms of patients and promote the improvement of renal function. The incidence of adverse reactions is low, and the safety is high. Clinical promotion. 2018 Vol. 24 (11): 1867-1869 [Abstract] ( 86 ) HTML (1 KB)  PDF (1252 KB)  ( 220 ) 1870 Diagnostic Value of the Change of Serum PCT SAA and CRP in Biliary Fistula after Intrahepatic Biliary Calculi Operation CHEN Guoli, FU Hua, ZHANG Xuejun DOI: 10.3969/j.issn.1006-6233.2018.11.027 Objective: To study the diagnostic value of the change of Serum PCT, SAA and CRP in biliary fistula after intrahepatic biliary calculi operation. Methods: The 232 cases with surgery of intrahepatic biliary calculi treated from April, 2015 to April, 2017 in our hospital, which were selected as the research objects, according to whether or not occuring the biliary fistula,were divided into the group of biliary fistula(21 cases) and non- biliary fistula(211 cases). The levels of PCT, SAA and CRP in the two groups were detected one day before operation, and one day after operation, two days after operation, three days after operation respectively. And then we compared th test. Results: No significant difference was found between the patients one day before operation and one day after operation in two groups on serum levels of PCT, SAA and CRP(P>0.05). But the patients two days after operation and three days after operation in the group of biliary fistula were higher than those of non- biliary fistula group, the difference had statistically significant(P<0.05). Conclusion: When patients in biliary fistula after intrahepatic biliary calculi operation, PCT, SAA and CRP levels have significantly elevated, which had significant assist of diagnostic value. 2018 Vol. 24 (11): 1870-1873 [Abstract] ( 110 ) HTML (1 KB)  PDF (1272 KB)  ( 310 ) 1874 The Effect of Video-assisted Thoracoscopy and Thoracotomy on the Treatment of Non-small Cell Lung Cancer and the Changes of Serum TGF-α CA21-1 HUANG Hongling, DENG Zhongbiao, HUANG Jinqi, et al DOI: 10.3969/j.issn.1006-6233.2018.11.028 Objective: To study the effect of video-assisted thoracoscopy and thoracotomy on the treatment of non-small cell lung cancer and the changes of serum transforming growth factor (TGF- alpha) and cytokeratin 19 fragment (CA21-1). Methods:80 patients of hypertension with diabetes mellitus who received therapy from February 2016 to February 2017 in our hospital were selected as research objects. According to the According to ballot method divided into observation group(n=40) and control group(n=40). The observation group was treated with video-assisted thoracoscopic lobectomy,The control group was treated with conventional thoracotomy for lobectomy.Then the operation time, the amount of bleeding, the time of drainage, the clearance of lymph nodes, the operation indexes of the time of hospitalization, the VAS score, the adverse reaction, and the therapeutic effect in two groups were compared.Results:The intraoperative blood loss, drainage time and hospital stay in the observation group were significantly lower than those in the control group[(209.63±17.92)ml vs(321.42±19.36)ml,(4.80±1.20)d vs(6.97±1.72)d,(6.37±1.02)d vs(11.96±2.39)d](P<0.05);The VAS score was significantly lower than that of the control group [(1.01±0.30)score vs(2.34±0.52)score](P<0.05);The level of TGF- alpha and CA21-1 was significantly lower than that of the control group[(11.53±2.60)μg/L vs(20.69±3.86)μg/L,(3.18±0.52)μg/L vs(6.97±0.72)μg/L](P<0.05);The total incidence of adverse reactions was significantly lower than that of the control group [7.50% (3/40) vs42.86%(18/42)](P<0.05). Conclusions: Compared with video-assisted thoracoscopy and thoracotomy in the treatment of non-small cell lung cancer, video-assisted thoracoscopy is more effective.It can alleviate complications and postoperative pain, regulate immune function and reduce serum levels of TGF-alpha and CA21-1. It is beneficial to the prognosis of patients. It is better than conventional thoracotomy and can achieve satisfactory clinical efficacy. 2018 Vol. 24 (11): 1874-1877 [Abstract] ( 73 ) HTML (1 KB)  PDF (1274 KB)  ( 175 ) 1878 Clinical Study of Jintian Ge Capsule combined with Alfacalcidol Soft Capsules in the treatment of Diabetic Osteoporosis ZHANG Zhiliang, REN Hua, PANG Xiaofen DOI: 10.3969/j.issn.1006-6233.2018.11.029 Objective: To investigate the clinical efficacy of Jintian Ge capsule combined with alfacalcidol soft capsules on diabetic osteoporosis and its effect on blood sugar level, clinical symptoms and bone metabolism. Methods: 90 patients with diabetic osteoporosis treated in our hospital from June 2015 to January 2017 were randomly divided into two groups according to the random number table method. The control group was treated with Alfacalcidol Soft Capsules, and the observation group was treated with Jin Tian Ge capsule combined with Alfacalcidol Soft Capsules. After one year of the treatment,the curative effect, adverse reactions, blood sugar, bone pain symptom score, bone metabolism index and bone mineral density were compared between the two groups. Results: The total effective rate of the observation group (91.11%) was higher than that of the control group (75.56%), and the differences was statistically significant(P<0.05), and the levels of FBG and HbALc in the two groups were lower than those before the treatment, and the differences was statistically significant (P<0.05), but there was no significant difference in the level of FBG and HbALc in the two groups (P>0.05). The scores of bone pain symptoms in the two groups were lower than those before the treatment, and the differences was statistically significant (P<0.05), and that of the observation group was lower than that in the control group (P<0.05). The levels of bone alkaline phosphatase in the two groups were lower than before the treatment, and the differences was statistically significant (P<0.05), and the level of bone alkaline phosphatase in the observation group was lower than that of the control group and the level of osteocalcin was higher than that of the control group, and the differences was statistically significant(P<0.05). After treatment, the level of bone alkaline phosphatase in the two groups was lower than that before the treatment and the level of osteocalcin was higher than that before the treatment, and the differences was statistically significant(P<0.05), Tthe level of bone alkaline phosphatase in the observation group was lower than that in the control group, and the level of osteocalcin was higher than that of the control group, and the differences was statistically significant(P<0.05). There was no significant change in the level of blood calcium and blood phosphorus (P>0.05). After treatment, the BMD of femoral trochanter, femur neck and lumbar vertebra in the two groups were higher than that before treatment, and the differences was statistically significant(P<0.05), and the BMD in the observation group were higher than those of the control group, and the differences was statistically significant(P<0.05). The total incidence of adverse reactions in the two groups was not significantly different(P>0.05). Conclusion: The therapeutic effect of Jintian Ge capsule combined with alfacalcidol soft capsules on diabetic osteoporosis is significant. It can effectively relieve the pain symptoms, improve the bone metabolism and the BMD, but it has no effect on blood sugar. 2018 Vol. 24 (11): 1878-1882 [Abstract] ( 161 ) HTML (1 KB)  PDF (1290 KB)  ( 456 ) 1883 Effect and Prognostic Impact of Soft Mirror combined with Percutaneous Nephrolithotomy in the treatment of Complex Renal Calculi YUE Xiao, YAN Jing, WANG Qiang, et al DOI: 10.3969/j.issn.1006-6233.2018.11.030 Objective: To investigate the effect of soft mirror combined with percutaneous nephrolithotripsy in the treatment of complex renal calculi and its effect on prognosis. Methods: 97 patients with complicated renal calculi in our hospital from April 2016 to July 2015 were selected and divided into the observation group (n=50) and the control group (n=47) according to the different surgical treatment methods. The control group was treated with percutaneous nephrolithotomy. The observation group was treated with percutaneous nephrolithotomy combined with flexible mirror. The rate of stone clearance, residual stone and perioperative operation were compared, and the changes of preoperative and postoperative hemoglobin concentration, blood creatinine, material life, body function and psychological function were compared, and the complications of postoperative infection, ureteral injury, urinary fistula, massive hemorrhage and renal function injury were recorded. Results: After operation, the stone clearance rate of the observation group was 88% significantly higher than that of the control group, the stone clearance rate was 63.83%, the residual rate of stone in the observation group was 12% lower than that of the control group (36.17% (P<0.05)), and the operation time, the time after the operation and the time of hospitalization were shorter in the observation group than the control group (P<0.05), and the amount of intraoperative bleeding in the observation group. It was significantly lower than that of the control group (P<0.05). After the operation, the hemoglobin concentration in the two groups was reduced, the observation group was significantly lower than the control group (P<0.05). After the operation, the blood creatinine in the two groups was significantly higher than that before the operation, and the observation group was higher than the control group (P<0.05). After the operation, the scores of the life quality indexes of the body function, material life and psychological function of the two groups were all higher than those before the operation. And the observation group was significantly higher than that of the control group (P<0.05). After the operation, the two groups had complications such as infection, ureteral injury, urinary fistula, massive hemorrhage and renal function injury, but the total incidence of the observation group was 10% lower than that of the control group (31.91% (P<0.05)). Conclusion: The treatment of complicated renal calculi with soft lens combined with percutaneous nephrolithotomy can improve the stone clearance rate, shorten the patient's time of hospitalization, improve the quality of the saint lake, and have small complications and high safety. It is worthy of clinical application. 2018 Vol. 24 (11): 1883-1886 [Abstract] ( 76 ) HTML (1 KB)  PDF (1271 KB)  ( 158 ) 1887 Analysis on the Curative Effect of Nasal Irrigation Combined with Mometasone Furoate Aqueous Nasal Spray in treatment of Patients with Allergic Rhinitis and the Influence on Serum IL-5 and Osteopontin YANG Liang, ZHANG Jianwei, NI Ze, et al DOI: 10.3969/j.issn.1006-6233.2018.11.031 Objective: To analyze the curative effect of nasal irrigation combined with Mometasone Furoate Aqueous Nasal Spray in treatment of patients with allergic rhinitis and the influence on serum interleukin-5 (IL-5) and osteopontin (OPN). Methods: 102 patients with allergic rhinitis were divided into control group (n=51) and experimental group (n=51) by lottery, the control group was treated with mometasone furoate nasal spray, experimental group treated with nasal irrigation joint Mometasone Furoate Aqueous Nasal Spray. IL-5, IL-10, IL-17, OPN, immunoglobulin-E (IgE), eosinophil (Eos), airway viscosity resistance R5 and R20, resonance frequency (Fres), signs and symptoms score, curative effect and adverse reactions of two groups were compared. Results: After treatment, the IL-5,IL-17, OPN, IgE, Eos, R5, R20, Fres OF experimental group was lower than the control group (P<0.05). The IL-10 of experimental group was higher than the control group (P<0.05). The signs and symptoms score, efficient of experimental group was better than that of control group (P<0.05). The adverse reactions was no differences between the two groups (P>0.05). Conclusion: The method of nasal irrigation combined with mometasone furoate aqueous nasal spray in treatment of patients with allergic rhinitis has high safety and curative effect. It can reduce the levels of serum IL- 5 and osteopontin. 2018 Vol. 24 (11): 1887-1891 [Abstract] ( 76 ) HTML (1 KB)  PDF (1291 KB)  ( 218 ) 1892 Clinical Study and Safety of Intraventricular Injection with Lebezumab in the treatment Neonatal Vascular Eye Disease YANG Jinshou, ZHANG Rong, QI En DOI: 10.3969/j.issn.1006-6233.2018.11.032 Objective: To explore the clinical effect and safety of intraventricular injection with lebezumab in the treatment neonatal vascular eye disease. Methods: 78 patients with choroidal neovascularization admitted to our hospital from February 2016 to December 2017 were randomly divided into control group and study group, 39 cases in each group. The control group was treated with vitrified photodynamic therapy (PDT), and the study group was treated with intravitreal injection of razomab. The clinical efficacy, best corrected visual acuity, macular foveal retinal thickness (CRT), and adverse reactions were compared between the two groups. Results: The effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P<0.05). There was no difference in the best corrected visual acuity and CRT between the two groups before treatment (P>0.05). The best corrected visual acuity and CRT of the two groups increased in 1 month and decreased in 6 months after treatment, and the change was more obvious in the study group. There were significant differences in the best corrected visual acuity and CRT between the two groups in 1 month and 6 months after treatment (P<0.05). The incidence of adverse reactions in the control group and the study group were 10.26% (4/39) and 12.82% (5/39), respectively. There was no significant difference between the two groups (P > 0.05). Conclusion: Intravitreal injection of razomab in the treatment of choroidal neovascularization has a prominent effect. And it can improve visual acuity, improve retinal edema, worthy of clinical promotion. 2018 Vol. 24 (11): 1892-1894 [Abstract] ( 91 ) HTML (1 KB)  PDF (1254 KB)  ( 460 ) 1895 Efficacy and Related Factors of Hyperbaric Oxygen Therapy for Severe Craniocerebral Trauma LU Youming, CHEN Xin, ZHANG Aijun DOI: 10.3969/j.issn.1006-6233.2018.11.033 Objective: To investigate the clinical efficacy and related influencing factors of hyperbaric oxygen therapy for severe traumatic brain injury. Methods: Fifty-six patients with severe craniocerebral trauma admitted to our hospital during April 2015 to February 2018 were all treated with hyperbaric oxygen therapy. Their clinical data were retrospectively analyzed and patients were prospectively analyzed with Disability Rating Scale (DRS). Efficacy was assessed and statistical analysis was performed on the relevant influencing factors. Results: Compared with before treatment (25.1±4.7 points), the DRS score (12.7±5.6 points) decreased significantly after treatment (P<0.05); the frequency of hyperbaric oxygen therapy, tracheotomy, basic diseases, The injury site and the number of craniocerebral operations did not significantly affect the long-term outcome of hyperbaric oxygen therapy in severe traumatic brain injury (P>0.05), but the time of hyperbaric oxygen therapy, GCS score on admission, and neurological complications affect this The main factors of long-term curative effect of patients (P<0.05) were treated with hyperbaric oxygen therapy within 29 days after injury. The patients' DRS score was significantly better than that after 30 days. The difference was significant (P<0.05). Conclusion: Hyperbaric oxygen therapy for patients with severe traumatic brain injury can effectively improve the prognosis of patients, including hyperbaric oxygenation time, GCS score at admission,Neurological complications are the main factors affecting the long-term efficacy of patients. The timing of hyperbaric oxygen therapy is the most significant. 2018 Vol. 24 (11): 1895-1898 [Abstract] ( 67 ) HTML (1 KB)  PDF (1263 KB)  ( 182 ) 1899 Comparison of Two Different Vascular Recanalization Methods in Acute Cerebral Artery Occlusion CHU Guifen, ZHANG Hong, LI Gaohua, et al DOI: 10.3969/j.issn.1006-6233.2018.11.034 Objective: To compare the application of two different ways of vascular recanalization (mechanical thrombectomy and arterial thrombolysis) in acute cerebral artery occlusion. Methods: The clinical data of 68 patients with mechanical thrombectomy in our hospital and 50 cases of arterial thrombolytic patients were retrospectively analyzed. The changes of NIHSS score before and after operation, puncture to repassage time, blood vessel repassage rate, incidence of intracranial hemorrhage, mortality and 3 months mRs after operation were compared between the two groups. Results: The time of the puncture and repassage of the patients in the mechanical thrombectomy group was significantly lower than that of the arterial thrombolytic group (P<0.05); the repassage rate of the patients in the mechanical thrombectomy group was significantly higher than that of the arterial thrombolysis group (P<0.05). The total incidence rate of intracranial hemorrhage were significantly lower than that in the arterial thrombolytic group (P<0.05); and there was no significant difference between the two groups after 3 months' mRS score and the NIHSS score (P>0.05); the good prognosis rate of the patients in the mechanical thrombectomy group was significantly better than that in the arterial thrombolysis group (P<0.05) at 3 months. Conclusion: Compared with the thrombolytic therapy, the treatment of thrombolytic therapy for the patients with acute cerebral artery occlusion has a wider time window, with a higher repassage rate, lower bleeding rate, which is beneficial to improve the prognosis of the patients, and should be advocated in clinical. 2018 Vol. 24 (11): 1899-1902 [Abstract] ( 65 ) HTML (1 KB)  PDF (1269 KB)  ( 175 ) 1903 Analysis of Clinical Efficacy and Safety of Patients with Parkinson's Disease Treated with Metoprolol and Pramipexole CHEN Dan DOI: 10.3969/j.issn.1006-6233.2018.11.035 Objective: To study the effect of treatment with midazolam and pramipexole on clinical efficacy and safety in patients with Parkinson's disease. Methods: A total of 95 patients with Parkinson's disease treated in our department from May 2015 to March 2017 were selected. The random number table was divided into control group (n=42) and study group (n=53). Patients in the control group were treated with metoprolol, and patients in the study group were treated with metopa and pramipexole. The UPDRS II, UPDRS III, and UPDRS IV scores before and after treatment were compared between the two groups of patients, and the excellent rate of treatment and the occurrence of adverse reactions during treatment were compared. Results: There was no significant difference in the UPDRS II, UPDRS III, and UPDRS IV scores between the two groups (P>0.05). The UPDRS II and UPDRS III scores at the 8th and 12th week after treatment were significantly lower in the study group than in the control group. The scores at the 12th week after treatment in both groups were significantly lower than those at the 8th week after treatment. The scores at the 8th and 12th week after treatment were significantly lower than those before treatment in both groups and were statistically significant. Difference (P<0.05). The rate of excellent treatment in the control group was 59.52%, which was significantly lower than that in the study group (88.68%). There was a statistically significant difference (χ2=4.504, P<0.05). The incidence of adverse reactions in the control group was significantly higher than that in the study group (23.81%), which was 7.55%, with statistical significance (χ2=5.309, P<0.05). Conclusions: The treatment of Parkinson's disease patients with midazolam combined with pramipexole can improve the clinical curative effect, which is beneficial to improve the daily living ability and motor function of patients, and has a higher safety. 2018 Vol. 24 (11): 1903-1905 [Abstract] ( 75 ) HTML (1 KB)  PDF (1252 KB)  ( 182 ) 1906 Clinical Study of Ai Sciplan combined with Ozagrel in the treatment of Acute Cerebral Infarction with Anxiety and Depression YIN Yanling, WANG Yanfei, MA Juan, et al DOI: 10.3969/j.issn.1006-6233.2018.11.036 Objective: To explore clinical study of escitalopram combined with ozagrel sodium in the treatment of acute cerebral infarction (ACI) combined with anxiety and depression. Methods: The subjects were 110 ACI patients with anxiety and depression admitted to our hospital from February 2015 to November 2017. They were divided into control group and observation group by random number table, each of 55 cases. The control group was treated with ozagrel sodium and the observation group was treated with escitalopram on the basis of it. All the patients were treated for 12 weeks. The clinical effects of the two groups were compared. The changes of the related scales (NIHSS, Barthel index, SAS and SDS), the levels of neuropeptide Y (NPY), substance P (SP) and the adverse reactions were observed before and after treatment. Results: After 12 weeks treatments, the total effective rate of observation group was higher than that of control group, and there was statistical difference (94.55% VS 74.55%, P<0.05). Observation group's NIHSS, SAS and SDS scores and serum SP levels were significant lower than those in control group at same time (P<0.05), BI score and serum NPY level were significant higher (P<0.05). Here was no significant difference in the incidence of adverse reactions between two groups (41.42% VS 36.36%, P>0.05). Conclusion: Escitalopram combined with ozagrel sodium helps patients with ACI combined with anxiety and depression to adjust psychological state, promote the recovery of nerve function with accurate effect. It is safe and reliable. 2018 Vol. 24 (11): 1906-1909 [Abstract] ( 57 ) HTML (1 KB)  PDF (1264 KB)  ( 201 ) 1910 Application of Tuberculosis Interferon γ-release Assay combined with Hydrothorax and Ascites ADA Detection in the Diagnosis of Tuberculosis BAI Yun, WANG Haifeng, ZHU Hongyan DOI: 10.3969/j.issn.1006-6233.2018.11.037 Objective:To investigate the value of tuberculosis interferon γ (IFN-γ) release assay combined with hydrothorax and ascites adenosine deaminase (ADA) detection in the diagnosis of tuberculosis. Methods: A total of 150 patients with suspected tuberculosis treated in our hospital during the period from December 2016 to February 2017 and 30 healthy volunteers (healthy group) who received physical examination in our hospital during the same period were enrolled in this study. They were divided into the tuberculosis group and the non-tuberculosis group according to the results of percutaneous biopsy. All patients underwent tuberculosis IFN-γ release assay, and samples of hydrothorax and ascites was collected for ADA detection. Results: The positive rate of IFN-gamma release assay, ADA level in pleural and ascites, IFN-gamma release assay and ADA positive rate in pleural and ascites in tuberculosis group were significantly higher than those in non-tuberculosis group and healthy group (P<0.05), but there was no significant difference between non-tuberculosis group and healthy group (P > 0.05). IFN-gamma release assay combined with ADA in pleural and ascites was more effective in the diagnosis of tuberculosis than the single test. Conclusion: The combination of tuberculosis IFN-gamma release assay and detection of ADA level in pleural and ascites can effectively improve the clinical diagnosis of tuberculosis. It is suitable for clinical popularization and application. 2018 Vol. 24 (11): 1910-1913 [Abstract] ( 76 ) HTML (1 KB)  PDF (1275 KB)  ( 185 ) 1914 Clinical Efficacy and Safety of Tigecycline in the Treatment of Multidrug or Pan-resistant Acinetobacter Baumannii Infection FAN Ruijuan, JIA Wei DOI: 10.3969/j.issn.1006-6233.2018.11.038 Objective:To analyze the clinical value of tegafycline in the treatment of multidrug or pan drug resistant Acinetobacter baumannii infection. Methods: 98 patients with multi-drug or pan-drug resistant Acinetobacter baumannii infection were selected from April 2015 to November 2017. Forty patients (April 2015 to May 2016) received routine sulbactam/cefoperazone antibiotic therapy, and 58 patients (June 2016 to November 2017) received tigacycline in combination. The two groups were treated before and after treatment. The clearance rate of pathogenic bacteria and changes of inflammatory indexes were observed and analyzed. Results: The total effective rate of the observation group (79.31%) was significantly higher than that of the control group (57.50%), the difference was significant (P<0.05). The levels of PCT, CRP and WBC in the observation group were significantly lower than those in the control group after treatment (P<0.05). The total clearance rate of pathogens in the observation group was significantly higher than that in the control group (P<0.05). Conclusion: Tigacycline can effectively enhance bacterial clearance by treating multidrug-resistant or pan-drug-resistant Acinetobacter baumannii, and has a very positive effect on improving clinical symptoms of patients. 2018 Vol. 24 (11): 1914-1916 [Abstract] ( 101 ) HTML (1 KB)  PDF (1253 KB)  ( 247 ) 1917 Effects of Azithromycin combined with Fat Soluble Vitamins on Inflammatory and Immune Factors in Children with Mycoplasma Pneumoniae Pneumonia WANG Rongliang DOI: 10.3969/j.issn.1006-6233.2018.11.039 Objective: To study the effect of azithromycin combined with fatsoluble vitamin (FV) on inflammatory and immune factors of child patients with mycoplasma pneumoniae pneumonia(MPP). Methods: A total of 108 cases of MPP child patients treated in our hospital from December 2014 to November 2017 were included into this study, and divided into combination group and control group using the random number table method, with 54 cases in each group. Patients in control group were performed conventional therapy plus azithromycin sequential therapy, and based on this, patients in combination group were performed FV trerapy. The symptoms, improvement time of signs, hospitalization time, levels of serum inflammatory factors, immune factors and chemotactic factors before and after treatment of the two groups were observed. Results: The extinction time of dyspnea, cough and lung rale, fever clearance time and hospitalization time in combination group were shorter than those in control group (P<0.05). After treatment, the serum levels of IL-8, IL-10, IL-13 and TNF-α in combination group were lower than those in control group (P<0.05). The serum levels of C3, C4, IgA, IgM and IgG in combination group were lower than those in control group(P<0.05). The serum levels of CysLTs, MDC and MCP-4 in combination group were lower than those in control group (P<0.05). The total effective rate in combination group (96.30%) was higher than 77.78% in control group (P<0.05). Conclusion: Azithromycin combined with FV can effectively remove serum inflammatory factors, improve serum immune factors and chemokines in children with MPP. It is effective, safe and reliable. 2018 Vol. 24 (11): 1917-1921 [Abstract] ( 60 ) HTML (1 KB)  PDF (1232 KB)  ( 188 ) 1922 Effect of Aspirin combined with Clopidogrel on Oxidative Stress and Hemorheology in Patients with Cerebral Infarction LI Li, WANG Qi, ZHANG Na, et al DOI: 10.3969/j.issn.1006-6233.2018.11.040 Objective: To analyze the curative effect of aspirin combined with clopidogrel in treatment cerebral infarction and its effect on oxidative stress response and blood rheology. Methods: 106 patients with cerebral infarction were divided into 50 control group and 56 observation group according to the simple random number table. The control group was treated with aspirin, and the observation group was treated with clopidogrel on the basis of the control group. The clinical efficacy, oxidase activity, hemorheology, neurological deficit scale (NIHSS), ability of daily living (ADL), follow-up and incidence of adverse reactions were compared between the two groups. Results: The effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). The levels of malondialdehyde (MDA) and superoxide dismutase (SOD) and catalase (CAT) in the two groups decreased 7 and 14 days after treatment, and the changes in the observation group were more significant (P<0.05). NIHSS decreased and ADL scores increased in both groups, and the changes in the observation group were more obvious (P<0.05). The plasma viscosity, whole blood viscosity and platelet aggregation rate of the two groups decreased, and the observation group was lower than the control group (P<0.05). The recurrence rate of the observation group was lower than that of the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Clinical curative effect of aspirin combined with clopidogrel in treatment patients with cerebral infarction is better than aspirin alone, which can reduce oxidative stress response, improve blood rheology and short-term prognosis., and do not increase adverse drug reactions. 2018 Vol. 24 (11): 1922-1925 [Abstract] ( 69 ) HTML (1 KB)  PDF (1264 KB)  ( 136 ) 1926 Application of Product pipe Circle in Improving the Awareness Rate of Health Knowledge of Hospitalized Patients in Department of Hematology SUN Rong, GAO Hua DOI: 10.3969/j.issn.1006-6233.2018.11.041 Objective: To observe the application effect analysis on the rate of awareness of health knowledge in the hospital for hospitalized patients in the Department of Hematology. Methods: In our hospital recently from Jun. 2017 to Dec. 2017 of the Department of Hematology in our hospital 100 cases of hospitalized patients randomly divided into two groups, 50 patients in each group, the B group adopted routine health education, take a method of management quality control circle. The awareness rate of health education, the incidence of adverse events due to lack of health knowledge, the survey of nursing satisfaction and the quality of life of two groups of patients after discharge 1 months were analyzed. Results: From the awareness rate of health education, satisfaction rate, group A were 100%, 100%; group B were 80% and 90%, the rate of adverse events occurred in patients with low incidence rate was 2%. The awareness of health education, group B was 40%, the quality of life after discharge were two groups of patients are improved, including group A is better than that of group B, the difference was statistically significant (P<0.001). Conclusion: In patients hospitalized in Department of Hematology, QCC, can effectively improve the hospital health education knowledge awareness rate, decrease due to lack of health knowledge and the incidence rate of adverse events, improve patient satisfaction with nursing care, improve the nurse patient relationship, and achieved good results, it is worthy of clinical promotion. 2018 Vol. 24 (11): 1926-1929 [Abstract] ( 80 ) HTML (1 KB)  PDF (1316 KB)  ( 381 ) 1930 Investigation and Analysis of Intestinal Infectious Diseases in Chengde in 2006-2016 WANG Wei, et al DOI: 10.3969/j.issn.1006-6233.2018.11.042 Objective: To analyze the epidemic trend and characteristics of Class A and B intestinal infectious diseases in Chengde, and to provide scientific basis for the prevention and control of intestinal infectious diseases. Method: Data of confirmed cases of Class A and B intestinal infectious diseases in Chengde from 2006 to 2016 were collected and analyzed with Excel and SPSS statistical software. Results: A total of 8069 cases of intestinal infectious diseases with no death case were reported from 2006 to 2016 in chengde and the average annual incidence rate were 21.26/100000 . The ratio of males and females was 1.65:1.There was no significant difference between the incidence of males and females (χ2=33.45, P<0.01). There were cases in all counties of chengde city. The top diseases were bacillary dysentery. The incidence rate among 0~14 years was the highest. In occupation, the incidence rates of farmers (40.85%) and scattered children (27.66%) were higher. Conclusion: Bacillary dysentery is the focus of prevention and treatment of class A and B infectious diseases in Chengde. Scattered children are the focus group. Surveillance of intestinal infectious diseases should be strengthened to control the occurrence and development of the epidemic. 2018 Vol. 24 (11): 1930-1932 [Abstract] ( 70 ) HTML (1 KB)  PDF (1447 KB)  ( 164 ) 1933 Effects of Laboratory Diagnosis of Hemolytic Disease of Newborn in Minjiang District LI Hongbing, RAN Bolin, WANG Chun, et al DOI: 10.3969/j.issn.1006-6233.2018.11.043 Objective: To analyze the laboratory test results of hemolytic disease of newborn (HDN) in Minjiang District, and to study the clinical value of blood group distribution and hemolysis three tests in the diagnosis of HDN. Methods: A total of 1,147 suspected HDN samples were collected from the Department of Obstetrics and Pediatric Department of Minjiang Central Hospital from August 2012 to August 2016. The hemolysis three tests, namely, direct antiglobulin test (DAT), free antibody test (FAT) and antibody released test (ART) were performed by the micro-column gel technique, and results were analyzed. Results: Of the 1,147 samples, there were 788 cases (68.70%) of maternal- fetal blood group incompatibility, 481 cases of positive HDN and the positive rate was 61.04% (481/788). Results of hemolysis three tests of 481 cases with HDN showed that the positive rates of DAT, FAT and ART were 28.27% (136/481), 86.90% (418/481) and 100%, respectively. Compared with the other three kinds of combination, the positive rate of FAT+ART was significantly higher (P<0.05). In 788 specimens of blood group incompatibility, the positive rate of ABO-HDN was significantly higher than that of Rh-HDN [73.01% (468/641) vs 8.84% (13/147)] (P<0.05). The positive rate of type A HDN was 81.46% (246/302) in 641 ABO blood group incompatibility specimens, which was significantly higher than that of type B HDN [66.08% (224/339)] (P<0.05). In 147 Rh blood group incompatible specimens, the positive rate of Rh D-HDN was 16.18% (11/68), which was significantly higher than Rh E-HDN positive rate [3.92% (2/51)] or Rh C-HDN positive rate [0% (0/28)] (P<0.05). Conclusion: In the hemolysis three tests, the sensitivity of ART is the highest, which is the strongest evidence for the diagnosis of HDN. The incidence of HDN is significantly higher in mothers and infants with ABO blood group incompatibility than in those with Rh blood group incompatibility, and type A is significantly higher than type B in ABO blood group system. Rh D is the highest in Rh blood group system. 2018 Vol. 24 (11): 1933-1936 [Abstract] ( 69 ) HTML (1 KB)  PDF (1256 KB)  ( 150 )

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