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2018 Vol. 24, No. 9 Published: 2018-09-20 1409 Effects of SOX11 Overexpression on Proliferation and Apoptosis of Retinoblastoma of Y79 Cells HUANG Xiaohan, TANG Shaohua, LIU Shuang, et al DOI: 10.3969/j.issn.1006-6233.2018.09.001 Objective: To explore the effects of SOX11 overexpression on proliferation and apoptosis of retinoblastoma of Y79 cells and the underlying mechanism. Methods: Y79 cells were transfected with pcDNA3.1-SOX11 plasmid or pc-DNA3.1-mock. Stable overexpression of SOX11 Y79 cells were collected for the following functional experiments. The effects of SOX11 overexpression on cell proliferation were examed by Edu cell immunofluorescence staining assay. Cell apoptosis were analyzed by Hoechst 33342 staining assay. Akt phosphorylation and PTEN protein expression were detected by Western blot assay. Results: The expression of SOX11 mRNA in SOX11 overexpression group were higher than control group [(354±26.2)% vs (100±1.3)%,P<0.05]. The OD 450nm value of SOX11 overexpression group were lower than control group(2.8±0.3 vs 4.5±0.3,P<0.05). The rate of proliferation cells in SOX11 overexpression group were decreased compared with control group [(12.4±4.3)% vs (32.3±3.3)%,P<0.05] detected by Edu cell immunofluorescence staining assay. The percentage of apoptosis cells in SOX11 overexpression group were higher than control group [(10.3±2.3)% vs (5.3±1.4)%,P<0.05] detected by Hoechst 33342 staining assay. The phosphorylation of AKT [(0.7±0.02)vs(0.4±0.02),P<0.05] was decreased, while PTEN expression [(0.3±0.03)vs(0.6±0.03),P<0.05]increased in SOX11 overexpression group compared with control group. The difference had statistical significance. Conclusion: SOX11 ovrexpression can inhibit Y79 cell proliferation and enhance apoptosis. PTEN/Akt signal pathway may involve in this process. 2018 Vol. 24 (9): 1409-1412 [Abstract] ( 68 ) HTML (1 KB)  PDF (1604 KB)  ( 183 ) 1413 Effect of Overexpression of GINS2 on Apoptosis of NB4 Cells and K562 Cells GAO Yanjun, XING Zhiwei, LIU Xiang, et al DOI: 10.3969/j.issn.1006-6233.2018.09.002 Objective: To observe its effect on leukemia cell apoptosis by using Ad-GINS2 infection. Methods: NB4 cells and K562 cells were infected by Ad-GINS2 and using fluorescence microscope observe the infection effect of NB4 cells and K562 cells; Apoptosis and cell cycle distribution of NB4 cells and K562 cells were detected by FCM;Bax and bcl-2 protein were detected by Western blotting test. Results: Fluorescence were observed by fluorescence microscope after 72h; Apoptosis rate was decreased significantly using FCM technology compared with the untreated group and no-load group(P<0.05);Results of cell cycle distribution showed that S, phase rate were increased and G1 phase rate were decreased in NB4 cells compared with the untreated group and no-load group(P<0.05);S G2 phase rate was increased and G1 phase rate were decreased in K562 cells compared with the untreated group and no-load group(P<0.05); Bax protein was decreased and bcl-2 protein was increased detected by Western blotting test. Conclusion: The recombinant adenovirus vector of GINS2 gene successfully infect NB4 and K562 cells and inhibit cell apoptosis, and then found that apoptosis may be related to the process of cell cycle, which lays a foundation for further clarifying the role of GINS2 gene white in leukemia. 2018 Vol. 24 (9): 1413-1415 [Abstract] ( 73 ) HTML (1 KB)  PDF (1740 KB)  ( 223 ) 1416 Effects of Matrine Preconditioning on Th1/Th2 Cytokines in Peripheral Blood of Rats with Cerebral Ischemia-reperfusion Injury XIAO Xu, SHI Wenda, CAI Chunhua, et al DOI: 10.3969/j.issn.1006-6233.2018.09.003 Objective: To investigate the effects of Matrine on Th1/Th2 subsets and activated cytokines in peripheral blood of rats with cerebral ischemia reperfusion injury. Methods: 50 SD rats were randomly divided into 5 groups, namely sham operation group, model group, matrine pretreatment group (4mg/kg, 8mg/kg, 16 mg/kg). 48 hours before operation, rats in both sham operation group and model group were gave saline by intraperitoneal injection, other drug pretreatment group were gaven matrine injection, respectively, bid for 2 days. Cerebral ischemia-reperfusion injury model in rats were established. 4h, 8h, 16h, 24h later, T cell subsets in femoral artery blood were detected by flow cytometry. Then the serum was separated and the cytokines (IL-1β, TNF-α, IL-4,and IL-10) were detected by ELISA. Results: The matrine pretreatment can significantly reduce the level of CD4+T cells in peripheral blood (P<0.05 or P<0.01), increase the level of CD8+T cells (P<0.05 or P<0.01), reduce the level of proinflammatory cytokines TNF-α and IL-1β in the activated Th1 cell (P<0.05 or P<0.01). Increase the level of anti-inflammatory cytokines IL-4 and IL-10 in the activated Th2 cells (P<0.05 or P<0.01). Conclusion: Matrine can play a neuroprotective role on cerebral ischemia reperfusion injury in rats by regulating Th1/Th2 cell subsets, adjusting cytokines in activatedTh1/Th2 cell and inhibiting inflammation reaction. 2018 Vol. 24 (9): 1416-1419 [Abstract] ( 70 ) HTML (1 KB)  PDF (1342 KB)  ( 223 ) 1420 Effect of Tongxinluo Capsule combined with Irbesartan on Early Diabetic Nephropathy and Serum Levels of CysC IL-18 ET-1 and NO WEI Hongfa, NING Jie, FENG Xiaoling DOI: 10.3969/j.issn.1006-6233.2018.09.004 Objective: To investigate the clinical efficacy of tongxinluo capsule combined with irbesartan (Irb) in the treatment of early diabetic kidney disease (DKD) and the effect on the serum cystatin C (CysC), interleukin (IL)-18, endothelin (ET)-1 and nitric oxide (NO) levels. Methods: 138 cases of patients with early DKD admitted in our hospital from Jan. 2015 to Jan. 2017 were selected and divided into two groups on a random basis. The control group was treated with Irb, while the observation group was administrated with tongxinluo capsule in combination with Irb. The clinical efficacy, changes of serum CysC, IL-18, ET-1, NO levels before and after treatment and occurrence of adverse reactions were compared between the two groups. Results: After 12 weeks of treatment, the total effective rate of the observation group was significantly higher than that of the control group (P<0.05). Compared with those before treatment, the serum CysC, IL-18 and ET-1 levels of both groups at 12 weeks after treatment were remarkably decreased(P<0.01), while the NO levels of both groups at 12 weeks after treatment were remarkably increased (P< 0.01). The serum CysC, IL-18 and ET-1 levels of observation group were significantly lower, while the serum NO level was much higher than those of the control group(P<0.01). There was no statistic difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The combination of Tongxinluo capsule and erbesartan in the treatment of early DKD can effectively improve its clinical efficacy and improve renal function with high safety. It may significantly reduce the level of serum CysC, IL-18, ET-1, increase the level of serum NO, and then improve the microinflammatory state and vascular endothelial function of the body. 2018 Vol. 24 (9): 1420-1423 [Abstract] ( 110 ) HTML (1 KB)  PDF (1346 KB)  ( 172 ) 1424 Predictive Value of sTREM-1 Combined Immunoassay for Short-term Prognosis of Senile Severe Pneumonia after Glucocorticoid Treatment TAN Nan, ZHAO Ning, ZHAO Kun, et al DOI: 10.3969/j.issn.1006-6233.2018.09.005 Objective: To explore the predictive value of serum soluble myeloid cell trigger receptor 1 (sTREM-1) combined with immunoassay in the short-term prognosis of elderly patients with severe pneumonia after glucocorticoid treatment. Methods: 92 patients with severe pneumonia treated in our hospital from Feb. 2014 to Jun. 2017 were treated with glucocorticoid. The serum levels of sTREM-1, immunoglobulin A (lgA), immunoglobulin M (lgM) and immunoglobulin G (lgG) were collected at the time of admission to the hospital.According to the treatment outcome of patients, they were divided into good outcome group and poor outcome group. The clinical characteristics of the two groups were compared. The predictive value of serum sTREM-1 combined immunoassay for prognosis of the patients was analyzed by drawing ROC curve. Logistic regression analysis was used to identify the independent risk factors of poor short-term prognosis. Results: Among the 92 patients, 70.65% were well transferred and 29.35% had poor prognosis. The serum sTREM-1 level in the good outcome group was lower than that in the adverse outcome group, and the levels of lgA, lgM and lgG in serum were higher than those in the adverse outcome group. There was a statistically significant difference between the two groups (P<0.05). The area under the curve of serum strem-1, serum lgA, serum lgM, serum lgG and four combined to predict the short-term prognosis of patients was 0.812, 0.793, 0.787, 0.852 and 0.869, respectively.Logistic regression analysis showed that serum sTREM-1>74.225pg/mL, serum lgA<0.674g/L, serum lgM<0.947g/L and serum lgG<5.755g/L were the risk factors of poor short-term prognosis (P<0.05). Conclusion: Serum sTREM-1 combined with immunoassay has a high sensitivity and specificity in predicting the short-term prognosis of elderly patients with severe pneumonia. It can be used as an important index for evaluating the condition of patients. 2018 Vol. 24 (9): 1424-1428 [Abstract] ( 78 ) HTML (1 KB)  PDF (2004 KB)  ( 155 ) 1429 The Relationship between the Pathological Characteristics of Laryngeal Carcinoma and Angiogenesis and Effect on the Short-term Efficiency GU Lei, WEN Fei, XIAO Jie DOI: 10.3969/j.issn.1006-6233.2018.09.006 Objective: To analyze the correlation of pathological features of laryngeal cancer with the angiogenesis and its impact in the short-term clinical effective rate. Methods: 120 patients with laryngeal cancer treated from February 2016 to February 2017 in our hospital were selected. The correlation of pathological features of laryngeal cancer with the angiogenesis was analyzeds; the subjects were divided into positive group and negative group according to the VM (vasculogenic mimicry) results. The clinical effective rate for two groups was compared. Results: The MVD (microvessel density) for patients over 60 years old was significantly higher than patients below 60 years old; the MVD for glottic patients was significantly higher than supraglottic and subglottic patients;the MVD for male patients was significantly higher than female patients;the MVD for poorly differentiated patients was significantly higher than moderately and highly differentiated patients (P<0.05); the MVD for T3 and T4 of patients was higher than T1 and T2 of patients; the MVD for N1-3 group was higher than N0 patients; the MVD for stage Ⅲ and Ⅳ of patients was higher than stage Ⅰ and Ⅱ of patients (P＞0.05); there were 67 positive cases of VM and HIF-1α(hypoxia-inducible factor); the results indicated that the two indicators were closely correlated with each other (r=0.526, P<0.0 5); the short-term effective rate for VM positive cases was lower than negative cases (P<0.05). Conclusion: There is a significant correlation between pathological features such as age, sex and degree of differentiation with angiogenesis, and the prognosis of VM positive patients is often poor, which needs to be paid attention to by medical staff. 2018 Vol. 24 (9): 1429-1432 [Abstract] ( 80 ) HTML (1 KB)  PDF (1329 KB)  ( 172 ) 1433 Effect of Cyclosporine Combined with Methylprednisolone Sodium Succinate on Serum Fibrosis Index and Urinary Beta 2-MG and mALB in Patients with Paraquat-induced Pulmonary Fibrosis FU Zhibin, WANG Zhenzhen DOI: 10.3969/j.issn.1006-6233.2018.09.007 Objective: To study effect of cyclosporine combined with methylprednisolone on paraquat induced pulmonary fibrosis in patients with serum fibrosis index and its effects on urine Urinary beta 2- microspheres (beta 2-MG) and microalbuminuria (mALB). Methods: 102 patients of paraquat induced pulmonary fibrosis who received therapy from Apr. 2015 to Apr. 2017 in our hospital were selected as research objects. According to draw method, all the patients were divided into the experimental group (n=50) and the control group(n=52). Two groups were given gastrointestinal lavage, nutritional supplements, analgesia, antibiotics, infection prevention and other conventional treatment, while the experimental group was on this basis, treated with cyclosporine combined with methylprednisolone, cyclosporin injection every time 5mg/kg, methylprednisolone every time 1000mg, once a day, after 4 days of treatment, decrease. Then serum fibrosis markers Hyaluronic acid (HA), laminin (LN), type IV collagen (CIV) and type III procollagen, Matrix metalloproteinase-9 (MMP-9) and matrix metalloproteinase inhibitor (T1MP-1) levels, urinary beta 2-MG, mALB levels, and Pulmonary high-resolution CT (HRCT) scores were compared. Results: The levels of HA, LN, C, IV and PC III in the experimental group were significantly lower than the control group(P<0.05); MMP-9, T1MP-1 level were significantly lower than the control group(P<0.05); β2-MG, mALB level were significantly lower than the control group(P<0.05); HRCT score were significantly lower than the control group(P<0.05). Conclusion: Cyclosporin combined with methylprednisolone sodium succinate can significantly reduce the index of serum fibrosis in patients with paraquat induced pulmonary fibrosis, alleviate the process of pulmonary fibrosis, reduce the level of urinary beta 2-MG and mALB, and reduce renal function damage. 2018 Vol. 24 (9): 1433-1436 [Abstract] ( 104 ) HTML (1 KB)  PDF (1315 KB)  ( 256 ) 1437 Effect of Levothyroxine Tablet on Serum sIL-2R CD44V6 TSGF Levels and p27 Expression in Elderly Patients with Thyroid Carcinoma HU Kun, LI Chunyan, TONG Yanchu DOI: 10.3969/j.issn.1006-6233.2018.09.008 Objective: To study the clinical effect of levothyroxine on the expression of p27 protein of elderly patients with thyroid cancer. Methods: 106 elderly patients with thyroid cancer in our hospital from Jun. 2014 to Jun. 2017 were divided into control group and observation group by simple random grouping method, 53 cases in each group. The control group was given hormone replacement therapy, the observation group was given levothyroxine treatment, both groups were treated for 1 month. The changes of serum sIL-2R,CD44V6, TSGF levels, T lymphocyte subsets levels and p27 expression in the thyroid cancer tissues before and after treatment were compared between two groups. Results: After treatment, the serum levels of sIL-2R, CD44V6 and TSGF in the observation group were (378.65±30.14)μ/mL,(310.84±21.78)ng/mL,(58.86±6.78)μ/mL, which were significantly lower than those of the control group [(436.90±33.72)μ/mL, (382.43±26.06)ng/mL, (62.73±7.40)μ/mL] (P<0.01). The serum levels of CD3+ and CD4+ in the observation group were (67.02±8.31) and (27.56±4.27), which were significantly higher than those of the control group [(58.94±7.83) and (35.07±3.88)] (P<0.01). The serum CD8+ level of observation group was (23.05±4.22), which was significantly lower than that of the control group (31.43±3.57) (P<0.01); the positive rate of p27(75.47%) expression in observation group was significantly higher than that of the control group (54.72%) (P=0.02). Conclusion: The levothyroxine tablet can decrease the expression of serum sIL-2RnCD44V6 TSGF and inhibit the expression of p27 protein in the serum of the elderly patients with thyroid carcinoma, and it can obviously improve the immune function of the patients, which is worth popularizing in clinic. 2018 Vol. 24 (9): 1437-1439 [Abstract] ( 77 ) HTML (1 KB)  PDF (1322 KB)  ( 164 ) 1440 Effect and Significance of Regular Antiepileptic Therapy on the Level of T Lymphocyte in Peripheral Blood of Epileptic Patients SHI Xiangsong, ZHANG Fuchi, WANG Xiaohua, et al DOI: 10.3969/j.issn.1006-6233.2018.09.009 Objective: To explore the effect and its clinical significance of regular antiepileptic therapy on the level of T lymphocyte in peripheral blood of epileptic patients. Methods: Among the epileptic patients who were admitted to our hospital during the period of Jan. 2014 to Dec. 2017, 90 cases of epilepsy patients in our hospital were selected for retrospective study, a total of 90 epileptic patients who met the inclusion criteria and exclusion criteria were selected for retrospective study, according to whether the patients took regular antiepileptic drugs in the past 3 months, they were divided into regular medication group and untreated group, and 50 healthy volunteers were selected as the control group in the outpatient department of our hospital during the same period. Peripheral venous blood was collected from the subjects, the peripheral blood T lymphocyte levels of CD3+, CD4+ and CD8+ were measured by flow cytometry, the ratio of CD4+/CD8+ was calculated, and the immunoglobulin levels, such as IgG and IgA, were detected by immunoturbidimetry. The levels of T lymphocyte and immunoglobulin in peripheral blood of three groups were compared. Results: The peripheral blood of patients in regular medication group and untreated group with CD8+ was significantly higher than the control group (P<0.05), CD3+, CD4+, CD4+/CD8+ were lower than the control group (P<0.05), and peripheral blood of CD8+ in regular medication group was lower than that of untreated group (P<0.05), CD3+, CD4+ and CD4+/CD8+ were higher than untreated group (P<0.05). IgG and IgA in the regular medication group and untreated group were lower than those in the control group (P<0.05), while the IgG and IgA in the regular medication group were higher than those in untreated group (P<0.05). Conclusion: The disorder of T lymphocyte and humoral immune function in peripheral blood is common in epileptic patients, while regular use of antiepileptic drugs can effectively correct the disorder of immune function in epileptic patients. 2018 Vol. 24 (9): 1440-1442 [Abstract] ( 90 ) HTML (1 KB)  PDF (1326 KB)  ( 241 ) 1443 Curative Efficacy of Bipolar Radiofrequency Discectomy in Treatment of Cervical Intervertebral Disc Protrusion and Effects on Serum IL-1β TNF-α and TXB2 Levels MA Bo, ZHANG Ning, GAO Yang, et al DOI: 10.3969/j.issn.1006-6233.2018.09.010 Objective: To investigate the effect of bipolar radiofrequency disc nucleoplasty on the clinical efficacy of cervical disc herniation and the effects on serum levels of interleukins (IL-1 beta), tumor necrosis factor (TNF- alpha) and thromboxane (TXB2) in patients. Methods: The clinical data of 96 cases of cervical disc herniation in our hospital from Dec. 2014 to Dec. 2016 were retrospectively analyzed. 48 cases of single stage radiofrequency were used as a single stage group and 48 patients with bipolar radiofrequency were used as a bipolar group. The monopole group was protrused RF needle at the base of the protrusion, while the bipolar group was protrused base is sandwiched between the two needle operating ends, the distance between two electrodes and tips should less than 0.8cm. The visual analogue scale (VAS), serum IL-1β, TNF-α, TXB2 and JOA scores before and after the operation, clinical efficacy and incidence of postoperative complications were compared between two groups. Results: On the 7th, 14th day after operation, the VAS score and serum IL-1β, TNF-α and TXB2 levels of both groups were significantly lower than those before operation (P<0.05), and the VAS score, serum IL-1β, TNF-α and TXB2 levels of bipolar group were significantly lower than those of the monopole group on the 7th, 14th day after operation (P<0.05); On the 14th, 30th day after operation, the JOA scores of both groups were significantly increased compared with those before treatment (P<0.05), and the JOA scores of bipolar group were significantly lower than those of the monopole group on the 14th, 30th day after operation (P<0.05); the excellent and good rate of bipolar group was significantly higher than that of the monopole group (P<0.05); there was no significant difference in the incidence of postoperative complications between the two groups (P＞0.05). Conclusion: Bipolar radiofrequency discectomy is prominently effective for cervical intervertebral disc protrusion, which can relieve the postoperative pain and improve the function of cervical spine, its intrinsic mechanism may be related to the decrease of serum IL-1β, TNF-α, TXB2 expression. 2018 Vol. 24 (9): 1443-1447 [Abstract] ( 67 ) HTML (1 KB)  PDF (1334 KB)  ( 161 ) 1448 Effect of Flat Mesh Tension-free Hernia Repair on Postoperative Pain and Rehabilitation in Elderly Patients with Indirect Inguinal Hernia LIANG Feng, LI Fei, NIE Shuangfa, et al DOI: 10.3969/j.issn.1006-6233.2018.09.011 Objective: To research the effect of onlay mesh hernioplasty on pain and the process of rehabilitation for elder patients with indirect inguinal hernia. Methods: 100 cases of elderly inguinal hernia treated in our hospital from Jan. 2016 to Nov. 2017 were selected and divided into two groups by random number table. 50 cases in the control group were filled with tension free herniorrhaphy. In the observation group, 50 cases were treated with onlay mesh hernioplasty. The operative time, intraoperative blood loss, hospitalization time, treatment cost, pain degree (VAS score), postoperative complications, recurrence and quality of life score were recorded. Results: After operation, the VAS scores of one day and 3 days in observation group were lower than those in control group (P<0.05).There was no significant difference in the time of operation, the amount of bleeding and the time of hospitalization in the two groups(P＞0.05). The treatment cost of the observation group was significantly lower than the control group(P<0.05). 3 months after the operation, the scores of the quality of life in the observation group were lower than the control group(P<0.05). There was no significant difference in the incidence of complications and recurrence rate between the two groups(P＞0.05). Conclusion: The treatment of elderly inguinal hernia by flat patch tension-free herniorrhaphy can effectively relieve the pain of the patients, promote rehabilitation, improve the quality of life, reduce the cost of treatment, and have fewer complications and recurrence. It is worthy of clinical application. 2018 Vol. 24 (9): 1448-1450 [Abstract] ( 69 ) HTML (1 KB)  PDF (1315 KB)  ( 183 ) 1451 Diagnostic Value of Optical coherence Tomography for Macular Degeneration of Retinal Vein Occlusion LI Hongying, et al DOI: 10.3969/j.issn.1006-6233.2018.09.012 Objective: To analyze the optical correlation tomography (OCT) diagnostic value for retinal vein occlusion macular degeneration, providing the basis for clinical diagnosis. Methods: 182 patients (230 eyes) with retinal vein occlusion were selected. All patients underwent laser induced choroidal retinal vein anastomosis. All patients underwent macular examination before and after OCT. The detection rates of macular lesions in two patients with retinal vein occlusion were compared. Results: OCT checked 114 cases(138 eyes) with macular degeneration, detection rate was 60.0% (138/230). Front mirror checked 85 cases(109 eyes)with macular degeneration, detection rate was 47.4% (109/230). Through the McNemar test, detection rate of OCT examination for retinal vein occlusion patients with macular lesion was higher than the front mirror examination (χ2= 10.345, P<0.01).Taking FFA examination as the "gold standard", the sensitivity and speciality of OCT examination diagnosing retinal vein occlusion patients with macular degeneration respectively was 95.7% (132/138), 96.7% (89/92); the sensitivity and speciality of front mirror examination respectively was 67.0% (73/109), 48.8% (59/121),the sensitivity and speciality of former were higher than the latter. Conclusion: OCT to macular lesion detection rate is higher in patients with retinal vein occlusion, having higher sensitivity and speciality. It can accurately found different types of macular structural changes and provide the effective diagnosis basis for the clinical doctors. 2018 Vol. 24 (9): 1451-1453 [Abstract] ( 66 ) HTML (1 KB)  PDF (1320 KB)  ( 179 ) 1454 The Changes of Lung Microbial in Patients with Acute Exacerbation of COPD with Respiratory Failure LIU Rong, GENG Xinpu, SHAO Xingxing DOI: 10.3969/j.issn.1006-6233.2018.09.013 Objective: To investigate the effect on the changes of lung microbial in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) with respiratory failure. Methods: 182 patients with acute exacerbation of COPD with respiratory failure from our hospital were selected. The sputum specimens were inoculated on blood plate, Jimmy Kang Kai, flat plate and flat sandy Paull chocolate. The drug resistance and changes of lung microbial continuity were tested and compared. Results: Gram-negative bacteria were the main bacteria, Gram-positive bacteria and fungi were more, and the proportion of microorganisms was gradually increasing (P<0.05). The resistance rate of tetracycline in Pseudomonas aeruginosa showed a downward trend (P<0.05). The drug resistance rate of amikanamycin, carbapenems, levofloxacin, piperacillin tazobactam and cefoperazone sulbactam increased (P<0.05). The resistance rates of the treatment of Bauman 's Acinetobacter to common antibiotics, carbon - and - resistant strains, and the resistance rates of the drug to the south of the Bacillus were higher,(P<0.05). The resistance rate of Klebsiella pneumoniae to gentamicin, carbapenem, beta lactamase inhibitor and three generation cephalosporins increased (P<0.05). There was a downward trend in piperacillin tazobactam (P<0.05). Escherichia coli was the most common drug resistance rate was on the rise,(P<0.05). The resistance rate of the drug in the south of the drug and the resistance of the ammonia to the south of the ammonia was decreased(P<0.05). Staphylococcus aureus s a rising trend in the use of antibiotics and most of the drug resistance rate,(P<0.05). Clindamycin resistance and SMZ-TMP rate decreased(P<0.05). Conclusion: The continuous changes in lung microbes in patients with acute exacerbation of COPD and respiratory failure have diagnostic significance for the development of acute exacerbation of COPD, the development of respiratory failure and the treatment of respiratory failure. 2018 Vol. 24 (9): 1454-1458 [Abstract] ( 78 ) HTML (1 KB)  PDF (1360 KB)  ( 144 ) 1459 The Value of Combined Detection of Serum Soluble ST2 and NT-proBNP in short-term Clinical Prognosis of CPR Patients WU Lizhu, YU Haixia, LIU Haiyang, et al DOI: 10.3969/j.issn.1006-6233.2018.09.014 Objective: To explore the relationship between the level of growth soluble ST2(sST2), NT-proBNP in peripheral blood and the recent clinical prognosis of cardiopulmonary resuscitation (CPR) . Methods: Serum sST2 levels were measured by ELISA in 160 patients with CPR immediately, 24 hours and 48~72 hours after CPR. The patients were divided into three groups according to the time of elevation of serum sST2. Group A: Serum sST2 levels were always lower than 200ug/L immediately after CPR, 24h, 48~72h, and group B: Serum sST2 levels were continuously elevated 24 hours, 48~72 hours after CPR and always higher than 200ug/L; group C: sST2 levels were continuously elevated 24 hours, 48~72 hours after CPR, but decreased 48~72 hours after CPR. Serum NT-proBNP levels were measured at each time point. The three groups were followed up for 6 months after CPR. Results: SST2 and NT-proBNP interact (P<0.05). The mortality of patients with high expression of sST2 (>200ug/L) and high expression of NT-proBNP (>400pg/ml) was higher than that of patients with low expression of sST2 and NT-proBNP (P<0.05). The mortality of group B was significantly higher than that of group A and group C (P<0.05), and the mortality of group A was lower than that of group C, but there was no significant difference (P>0.05). Conclusion: Combined detection of serum sST2 and NT-proBNP is expected to be a good indicator for predicting the short-term prognosis of patients with CPR. 2018 Vol. 24 (9): 1459-1462 [Abstract] ( 86 ) HTML (1 KB)  PDF (1412 KB)  ( 164 ) 1463 The Effect of 3D-CRT and VMAT on Thyroid Function in Patients with Head and Neck Cancers ZHANG Jun, LI Gang, REN Biyong, et al DOI: 10.3969/j.issn.1006-6233.2018.09.015 Objective: To study the effects of three-dimensional conformal radiation therapy (3D-CRT) and volume modulated arc therapy (VMAT) on thyroid function in patients with head and neck cancers. Methods: 140 patients with head and neck tumors from January 2011 to June 2014 underwent radiotherapeutics in Nuclear Medicine Department of Central Hospital of Chongqing Three Gorges Tumour Branch were randomly divided into group 3D-CRT and group VMAT, with 70 cases in each group, group 3D-CRT was treated with 3D-CRT, group VMAT was treated with VMAT, all patients were treated for 2 months and followed up for 24 months. The clinical efficacy at 2 months after radiotherapy was observed, the levels of serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) were measured before radiotherapy, at the end of radiotherapy, and at 3, 6, 12, 18 and 24 months after radiotherapy, QLQ-H&N35 scale score was used to evaluate the quality of life of patients before radiotherapy, 1 months for radiotherapy, after radiotherapy and 6 months after radiotherapy, the occurrence of hypothyrea during follow-up was recorded. Results: There was no significant difference in the total effective rate between the two groups at 2 months after radiotherapy (P>0.05); at 6, 12, 18 and 24 months after radiotherapy, the TSH in group VMAT was significantly lower than that in group 3D-CRT (P<0.05);at 12,18 and 24 months after radiotherapy, the FT3 and FT4 in group VMAT were significantly higher than those in group 3D-CRT (P<0.05); at 6 months after radiotherapy, the score of QLQ-H&N35 scale in group VMAT was significantly lower than that in group 3D-CRT (P<0.05); there was no significant difference in the incidence rate of hypothyrea between the two groups during the 24 months follow-up (P>0.05). Conclusion: 3D-CRT and VMAT are effective radiotherapy methods for head and neck cancers, but VMAT is superior to 3D-CRT in protecting thyroid function and improving quality of life after treatment. 2018 Vol. 24 (9): 1463-1466 [Abstract] ( 70 ) HTML (1 KB)  PDF (1344 KB)  ( 284 ) 1467 Clinical Observation of Midazolam Maleate Tablets combined with Quetiapine Fumarate in the treatment of Senile Dementia Complicated with Sleep Disorders WEN Yan, YANG Hui DOI: 10.3969/j.issn.1006-6233.2018.09.016 Objective: To explore the clinical efficacy of Midazolam Maleate Tablets combined with quetiapine fumarate in the treatment of senile dementia complicated with sleep disorders. Methods: 200 patients with Alzheimer's disease were treated in our hospital from September 2015~2017 to May. According to the order of admission, the patients were divided into control group and observation group, and 100 cases in each group were divided into 2 groups. After admission, the control group was treated with quetiapine alone, 100~150mg/ times, and 3 times /d; the observation group was treated with midazolam combined with quetiapine, and the dose and use of quetiapine were in the same control group, midazolam was taken in sleep 30min~1h and 7.5~15mg/ times for 8 weeks. The pathological changes of Alzheimer's disease (BEHA VE-AD) and the Pittsburgh sleep quality index scale (PSDI) were used to evaluate the pathological changes and sleep improvement of patients with dementia, and the changes in the expression of serum inflammatory factors of interleukin 1 β (IL-1 β) and tumor necrosis factor α (TNF-α) were detected in the 2 groups, and the 2 groups were treated for adverse reactions. Results: There were no cases of withdrawal or exfoliate in this group. The score of BEHA VE-AD scale in the 2 groups after 4 weeks and 8 weeks was significantly lower than that before the treatment, but the score of BEHA VE-AD scale in the observation group was lower than that of the control group after 8 weeks of treatment (P<0.05), and the score of the PSDI scale in the 2 groups was significantly lower than that before the treatment. Low, the score of sleep time, sleep quality, sleep disorder, sleep medication and daytime function in the PSDI scale of the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). The serum inflammatory index IL-1β and TNF-α in the observation group were lower than those before and after the treatment, the difference was statistically significant. The adverse reaction rates of the control group and the observation group were 17% (17/100) and 15% (15/100), respectively, and there was no significant difference between the 2 groups (P>0.05). Conclusions: The effect of Midazolam Maleate Tablets combined with quetiapine fumarate in the treatment of alzheimer's disease is significant, and it may be related to the inhibition of the expression of serum inflammatory reaction. The combination therapy is more stable and does not increase the adverse reaction. It is a reliable and safe treatment method. 2018 Vol. 24 (9): 1467-1470 [Abstract] ( 87 ) HTML (1 KB)  PDF (1341 KB)  ( 182 ) 1471 Retrospective Analysis of 104 Cases of Spontaneous Intracranial Hemorrhage in Children CHENG Zhenghai, et al DOI: 10.3969/j.issn.1006-6233.2018.09.017 Objective: To investigate the clinical manifestation, etiology and treatment of spontaneous intracranial hemorrhage in children. Methods: The clinical data of 104 cases of spontaneous intracranial hemorrhage in children from Jan. 2010 to Dec. 2017 (≤14 years old) were analyzed retrospectively, especially the findings of cerebral angiography, and their characteristics were elucidated. Results: The incidence of spontaneous intracranial hemorrhage in childhood with headache is more common (81/104 77.9%), and headache is the main clinical manifestation (59/104 56.7%). Some of the children with headache are complicated with facial and limb paralysis (20/59 33.9%), combined nausea and vomiting (23/59 39.0%), but combined hemiinas and speech disorders are rare. Cerebrovascular disease is the main reason, and cerebral arteriovenous malformation (AVM) accounts for 70.2%. Conclusion: There are many causes of headache in children. Sudden, atypical and severe headache children are likely spontaneous intracranial hemorrhage, and need further examination. Through early and timely diagnosis and reasonable treatment, the cure rate of the disease can be significantly improved. 2018 Vol. 24 (9): 1471-1474 [Abstract] ( 61 ) HTML (1 KB)  PDF (1314 KB)  ( 119 ) 1475 Study on the Relationship between Subclinical Hypothyroidism and Atherosclerosis in Different Types of Constitutions CHEN Jie DOI: 10.3969/j.issn.1006-6233.2018.09.018 Objective: To investigate the relationship between subclinical hypothyroidism and atherosclerosis in different types of constitutions. Methods: 85 cases of subclinical hypothyroidism in our hospital were selected as the subjects. The constitution classification of Chinese medicine was carried out by using the TCM body quality table and the classification and judgement of the constitution of Chinese medicine. Blood pressure, blood glucose and blood lipid [TG, TC, HDL-C, LDL-C], carotid intima media thickness (IMT) and the incidence of arteriosclerosis were compared in subclinical hypothyroidism patients with different physique types. Results: There are 9 types of TCM constitutions in patients with subclinical hypothyroidism, of which Qi deficiency, qi depression, Yang deficiency and yin deficiency are the main constitutions. Qi deficiency accounted for the highest proportion, reaching 24.71%, followed by qi depression 21.18%, Yang deficiency 18.82%, yin deficiency 15.29%. Mild constitution, phlegm dampness, hot and humid substance, peculiar nature and blood stasis constitution, 5 constitution is less, respectively 7.06%, 5.88%, 4.71%, 1.18%, 1.18%. The incidence of systolic blood pressure, LDL-C, IMT and arteriosclerosis in patients with Qi deficiency and qi depression were higher than those of other types of patients with subclinical hypothyroidism, the difference was statistically significant (P<0.05). There were no significant differences in the laboratory parameters, IMT and atherosclerosis, arteriosclerosis incidence between the other groups of patients with subclinical hypothyroidism (P>0.05). Conclusion: The main types of patients with subclinical hypothyroidism are Qi deficiency, qi depression, Yang deficiency, yin deficiency, and Qi deficiency and qi depression are closely related to atherosclerosis, which should be paid more attention to. 2018 Vol. 24 (9): 1475-1477 [Abstract] ( 83 ) HTML (1 KB)  PDF (1319 KB)  ( 185 ) 1478 A Prospective Study on the Near and Long Term Effect of Zero Incisor Cervical Interspace Fusion Fixator in the Treatment of Cervical Spondylosis SHEN Honglei, XU Hongjun, HUA Lei, et al DOI: 10.3969/j.issn.1006-6233.2018.09.019 Objective: To investigate the short-term and long-term difference in the treatment of cervical spondylosis with the fixed fusion of zero notch cervical intervertebral space fusion cage. Methods: 94 cases of patients with cervical spondylosis in our hospital were randomly divided into observation group and control group of 47 cases. The observation group was treated with fixed fusion with zero incisor cervical intervertebral space fusion cage, and the control group was treated with the traditional anterior titanium plate combined with Cage fusion system. The two groups of surgical related indexes, the Japanese Department of orthopedics (JOA) score, the interbody height, the fusion rate of bone graft and the incidence of complications were compared. Results: The operation time of the observation group was shorter than that of the control group (P<0.05). The amount of bleeding and the flow rate of the two groups were not statistically significant (P>0.05). 3 months, 6 months, 12 months and 36 months after operation, the JOA scores in the two groups were all higher than those before the operation (P<0.05). There was no significant difference in JOA scores at each time point between the two groups (P>0.05). The fusion rate of bone graft in the observation group was higher than that of the control group at 3 months after the operation (P<0.05). All the two groups had bone graft fusion at 6 months after operation. The intervertebral height at all time points in the two groups was higher than that before the operation (P<0.05), but there was no significant difference between the groups (P>0.05). The incidence of complications in the observation group was lower than that of the control group (P<0.05). Conclusion: Compared with the traditional anterior titanium plate combined with Cage fusion system for the treatment of cervical intervertebral fusion device, zero notch fixation and fusion in treatment of cervical vertebra disease curative effect is similar, but the shorter operation time, early bone graft fusion rate is higher, and the incidence of postoperative complications is low, more clinical value. 2018 Vol. 24 (9): 1478-1481 [Abstract] ( 87 ) HTML (1 KB)  PDF (1532 KB)  ( 205 ) 1482 A Study on the Comprehensive Treatment of Postpartum Hemorrhage in Caesarean Section by Modified B-Lynch Suture Combined Restrictive Rehydration Therapy with Carboprost Tromethamine Injection SHA Xiaolong, WANG Qian DOI: 10.3969/j.issn.1006-6233.2018.09.020 Objective: To investigate the safety and efficacy of Comprehensive treatment of postpartum hemorrhage in caesarean section by combined modified B-Lynch suture and restrictive rehydration therapy with Carboprost Tromethamine Injection. Methods: 100 cases of postpartum hemorrhage were selected and divided into the control group and the observation group according to the different treatment methods, so there are 50 patients in each group. The control group was treated with oxytocin combined with traditional suture and traditional fluid supplement. The observation group was treated with the combination of modified B-Lynch suture and restrictive fluid filling with Carboprost Tromethamine Injection. The amount of intraoperative bleeding, postoperative bleeding, blood transfusion, hemodynamic index and coagulation function were compared between the two groups. Results: The experimental results showed that the amount of bleeding, the amount of bleeding and the amount of blood transfusion in the observation group were lower than those of the control group. There was no complication in the observation group. The hemodynamic indexes of the observation group at 0.5h and 2h after treatment were better than those of the control group, there were significant differences in related hemodynamic indicators between the two groups, between different time points and between groups. The difference was statistically significant (P<0.05). The clotting function of the observation group was better than that of the control group at 6h and 12h after treatment. Conclusion: The Comprehensive treatment of postpartum hemorrhage in caesarean section by combined modified B-Lynch suture and restrictive rehydration therapy with Carboprost Tromethamine Injection is safe and reliable. 2018 Vol. 24 (9): 1482-1485 [Abstract] ( 73 ) HTML (1 KB)  PDF (1334 KB)  ( 137 ) 1486 The Effect of Exfoliation Excision of Peripheral Sympathetic Nerve Network in Common Carotid Artery in Children with Cerebral Palsy MU Cangshan, WANG Dong, JIN Huan, et al DOI: 10.3969/j.issn.1006-6233.2018.09.021 Objective: To observe the changes of ptyalism, dysphagia and cognitive function in children with cerebral palsy after the exfoliation excision of the sympathetic nerve network around the common carotid artery. Methods: The clinical data of 74 children with cerebral palsy treated by different ways in our hospital from October 2015 to May 2017 were retrospectively analyzed. The 37 children who were treated by rehabilitation were taken as the control group. The sympathetic surroundings of common carotid artery Nerve net stripping resection of children treated 37 cases as the observation group. The changes of arterial hemodynamics indexes of cerebral artery, and the improvement of ptyalism, dysphagia and cognitive function in the two groups were compared. Results: After treatment, the hemodynamic indexes of the cerebral artery in the observation group were superior to those in the control group (P<0.05); the Teacher Drooling Scale (TDS) score and the water swallow test score in the observation group were lower than those in the control group (P<0.05); the score of Wechsler Preschool and Primary Scale of Intelligence (WPPSI) in the observation group was higher than that in the control group (P<0.05). Conclusion: The application of exfoliation excision of the sympathetic nerve network around the common carotid artery in the treatment of children with cerebral palsy can significantly improve ptyalism and swallowing function, and can effectively promote the recovery of cognitive function. 2018 Vol. 24 (9): 1486-1488 [Abstract] ( 90 ) HTML (1 KB)  PDF (1315 KB)  ( 313 ) 1489 Analysis on Efficacy of Short Segment and Long Segment Fixation and Fusion for the treatment of Degenerative Scoliosis MA Yuan DOI: 10.3969/j.issn.1006-6233.2018.09.022 Objective: To explore the effect of short segment and long segment fixed fusion in the treatment of scoliosis. Methods: 120 cases of elderly patients who underwent adult degenerative scoliosis from February 2014 to October 2015 were divided into two groups according to the random number method. The control group and the observation group were There were 60 patients in each group who underwent surgical treatment with long segment and short segment fixation, respectively, to compare the effects of treatment. Results: The control group and the observation group patients in the operation time, operative blood loss and surgical segment number three relates to the difference index data were statistically significant (t=19.167, 1.756, 9.515, P<0.05), from the data, each value is higher than the observation group in the control group, the control group and the patients in the observation group were treated before the VAS data. The difference of leg pain and VAS disability index scores were not statistically significant (P>0.05), in the 2 years after treatment, the observation group and the control group of patients with VAS pain, leg pain and VAS disability index score before treatment data differences were statistically significant (P<0.05), and the value of three projects were for treatment after 2 years of lower than that before treatment, in comparison to 2 years after treatment of the data, differences between the control group and observation group were not statistically significant (P>0.05), the control group and the observation group of patients before treatment Scoliosis Cobb'Cobb' angle, kyphosis angle and lordosis angle difference, sagittal balance and coronal balance several data items were not statistically significant (P>0.05), in the 2 years after treatment, and the treatment of the numerical difference between the above 5 items before were statistically significant (P< 0.05), and scoliosis Cobb 'Cobb' angle, kyphosis angle, sagittal balance, lower than the value for 1 years after treatment of coronal balance in several items before treatment, the physiological lordosis angle is higher than the value of 2 years after treatment before treatment, in the treatment of scoliosis after one year, Cobb 'Cobb' angle, kyphosis angle of two projects, with statistical significance of the data of the observation group and the control group (P<0.05), and the numerical difference were the observation group than in the control group, lordosis angle, sagittal balance, coronal balance in three projects and the observation group There was no significant difference between the two groups (P>0.05). Conclusion: Short segment and long segment fixation have different advantages and disadvantages, in patients with scoliosis patients choose surgery program, we should fully consider the patient's own situation, if the patient's physical condition is better, and hope to achieve better Long-term treatment effect, then you can choose a long segment of fixed fusion, if the patient's physical condition is poor, the trauma is not high tolerance, it is recommended to use short-segment fixed fusion. 2018 Vol. 24 (9): 1489-1493 [Abstract] ( 71 ) HTML (1 KB)  PDF (1845 KB)  ( 113 ) 1494 Application of Analysis Modified Multiple U-type Uterine Compression Suture in Intractable Postpartum Hemorrhage FU Dan DOI: 10.3969/j.issn.1006-6233.2018.09.023 Objective: To investigate the effect of modified multi U-type uterine oppression suture in refractory postpartum hemorrhage. Methods: 80 patients with refractory postpartum hemorrhage admitted to hospital from October 2014 to October 2017 were randomly divided into two groups. Patients in the compression and suture group were given modified multiple U-type uterine pressure sutures. Patients in the B-Lynch group were treated with suture. B-Lynch suture was given to compare the perioperative indicators, stress, complications and quality of life between the two groups. Results: In the compression suture group, intraoperative blood loss, postoperative 2h and 24h hemorrhage, red blood cell and plasma infusion volume, length of stay, NE, E, MDA, ET-1 levels, hysterectomy, secondary anemia and menstrual abnormalities, the incidence was significantly lower than that of the B-Lynch suture group. The serum albumin and general health status at 24 hours were significantly higher than those at the B-Lynch suture group (P<0.05). Conclusion: The improved multi U-type uterine oppression suture has a significant effect on refractory postpartum hemorrhage. The prognosis is good and has implications for reference. 2018 Vol. 24 (9): 1494-1496 [Abstract] ( 91 ) HTML (1 KB)  PDF (1305 KB)  ( 122 ) 1497 Diagnostic Value of Hysteroscopic Water Injection and Transabdominal Ultrasound for Uterine scar Diverticulum DU Xiujuan, XU Hui DOI: 10.3969/j.issn.1006-6233.2018.09.024 Objective: To study diagnosis of uterine cicatricial diverticulum by hysteroscopic underwater transabdominal ultrasound. Methods: 240 patients uterine cicatricial diverticulum who received therapy from November 2014 to November 2017 in our hospital were selected as research objects, they were examined by hysteroscopic underwater transabdominal ultrasound and transvaginal ultrasound, the morphological and size of the diverticulum were measured, and the diagnostic value of the two ways of the uterine cicatricial diverticulum was compared. Results: The results showed that the detection rate of hysteroscopic underwater transabdominal ultrasound was 100% (240/240), while the rate of transvaginal ultrasound was 92.08% (221/240), the differences are statistically significant (P<0.05); the results of four meridians of depth, length, width and thickness of residual muscularis were measured respectively, the results of the depth, length and width in the hysteroscopic underwater transabdominal ultrasound were significantly larger than those in the transvaginal ultrasound [(13.82±2.41)mmvs(7.01±1.18)mm,(9.85±1.40)mmvs(8.14±1.19)mm,(14.29±2.35)mmvs(11.83±1.84)mm], the thickness of the residual muscularis is significantly thinner than those in the results of transvaginal ultrasound[(2.15±0.21)mmvs(2.98±0.74)mm], the differences are statistically significant (P<0.05). Conclusion: Hysteroscopic underwater transabdominal ultrasound in the diagnosis of uterine cicatricial diverticulum has a good value. And it can accurately understand the shape of the diverticulum, it's worthy of application and popularization. 2018 Vol. 24 (9): 1497-1500 [Abstract] ( 81 ) HTML (1 KB)  PDF (1490 KB)  ( 125 ) 1501 Analysis on Therapeutic Effect of Adenoidectomy for Children with Chronic Rhinosinusitis MA Shuwei, CHEN Jie DOI: 10.3969/j.issn.1006-6233.2018.09.025 Objective: To investigate the efficacy of adenoidectomy for children with chronic rhinosinusitis. Methods: 80 children with chronic rhinosinusitis admitted from January 2014 to December 2016 were randomly divided into two groups. The adenoidectomy was performed on the children in the surgery group, while the conventional group was given traditional routine treatment. The quantitative scores of disease symptoms, pain, endoscopic score, total effective rate and long-term prognosis were compared between the two groups. Results: The total score of SNOT-20 (5.90±1.04) was significantly lower in the surgical group than in the conventional group (8.52±1.20); the VAS score (2.05±0.50) and the Lund-Kennedy score (1.70±0.68) after the treatment. 0.68)Compared groups were significantly lower than the conventional group (4.11±1.07, 3.57±0.79); Total effective rate (97.5%) was significantly higher than the conventional group (67.5%); Physical pain at the end of follow-up (70.20±9.13), The overall health (78.25±9.05) and vitality score (80.23±9.16) groups were significantly higher than the conventional group (61.13±8.70, 67.23±10.04, 70.60±9.11), and the difference was statistically significant (P<0.05). Conclusion: Adenoidectomy has a significant effect on the treatment of chronic rhinosinusitis in children with a good prognosis. 2018 Vol. 24 (9): 1501-1503 [Abstract] ( 73 ) HTML (1 KB)  PDF (1308 KB)  ( 207 ) 1504 Observation on Curative Effect of Arthroscopic Knee Debridement Combined with Denervation Therapy on Patients with Knee Osteoarthritis Complicated with Cartilage Injury WAN Ruijie, CHEN Yu, XIAO Qiuke, et al DOI: 10.3969/j.issn.1006-6233.2018.09.026 Objective: To observe curative effect of arthroscopic knee debridement combined with denervation therapy on patients with knee osteoarthritis complicated with cartilage injury. Methods: Eighty-four cases of patients with knee osteoarthritis complicated with cartilage injury treated in our hospital were selected as the study objects. All the patients were divided into observation group and control group according to the random and equal principle. The control group were treated with arthroscopic knee debridement, and the observation group were combined with denervation therapy on the basis of the control group. Pain degree, knee function, clinical effects and complication rates were observed in the two groups. Results: After the operation, the VAS score of the two groups was significantly lower than that before the operation (P<0.05), and the observation group was significantly lower than the control group (P<0.05). The difference between the two groups after the operation was statistically significant (P<0.05). Lysholm scores at each time after operation were significantly lower than those before operation (P<0.05). There were no significant differences in the scores a month and three months after operation (P>0.05), while significant differences in the scores six months and twelve months after operation (P<0.05), with significant differences at each time after operation in the observation group (P<0.05) and no significant differences in the control group (P>0.05). The excellent rate of the observation group was 90.48% significantly higher than that of 71.43% of the control group (P<0.05). The incidence of complications in the observation group was 2.38% lower than that of 7.14% in the control group (P>0.05). Conclusion: Arthroscopic knee debridement combined with denervation for knee osteoarthritis complicated with cartilage injury can relieve pain and improve knee function. 2018 Vol. 24 (9): 1504-1507 [Abstract] ( 66 ) HTML (1 KB)  PDF (1420 KB)  ( 173 ) 1508 Clinical Study on Nasal Irrigation combined with Fluticasone in Patients with Allergic Rhinitis WANG Hong, LI Yan, GAO Jianhua, et al DOI: 10.3969/j.issn.1006-6233.2018.09.027 Objective: To study curative efficacy of nasal flushing combined with fluticasone propionate nasal spray in treatment of allergic rhinitis and its effects on ICAM-1 ECP IL-5 and osteopontin, and analyze the clinical effect. Methods: 142 patients of allergic rhinitis received therapy from may 2015 to may 2017 in our hospital were selected as research objects. According to different treatment regimens were divided into observation group and control group, the control group was treated with Nasal flushing, while the observation group was treated with nasal flushing combined with fluticasone propionate nasal spray. Then clinical effects, adverse reactions, serum ICAM - 1, ECP, IL-5 levels,nasal resistance and OPN,physical scores,symptom scores were compared,. Results: The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, serum ECP and IL-5 in the observation group were lower than those in the control group, and ICAM-1 was higher than those in the control group (P<0.05). The nasal resistance and OPN in the observation group was less than the control group (P<0.05). Physical scores and symptom scores in the observation group was less than the control group (P<0.05). Conclusion: Nasal irrigation combined with Fluticasone Propionate Nasal Spray in the treatment of allergic rhinitis, effectively improved the serum CAM-1, ECP, IL-5 levels and nasal resistance and OPN, alleviated the symptoms score and symptom score of the patients, and improved the clinical efficacy, and had less adverse reactions. 2018 Vol. 24 (9): 1508-1511 [Abstract] ( 83 ) HTML (1 KB)  PDF (1333 KB)  ( 203 ) 1512 Influence Analysis of Multiple Diseases on Clinical Characteristics of Elderly Patients with Heart Failure XU Qi, WANG Hongqi, XIN Guoyong DOI: 10.3969/j.issn.1006-6233.2018.09.028 Objective: To analyze the clinical features of heart failure with multiple etiological factors in seniors, so as to provide scientific basis for clinical prevention and treatment. Methods: A retrospective analysis was made on hospitalized medical records of heart failure patients aged 60 or above in our hospital. According to the number of etiological factors divided into single-cause group, double-cause group and multi-cause group were compared to summarize the clinical characteristics of multi-cause heart failure. Results: A total of 249 cases of senile heart failure were collected, of which there were 83 cases of single pathogeny group, 79 cases of two pathogenesis group and 87 cases of multiple pathogenesis group. The most common combination of double pathogenesis was coronary heart disease and hypertension (28 cases, 35.4%). There were 46 cases (52.9%) with three etiological factors and 34 cases (39.1%) with four etiological factors in the multi-etiological group. The indexes of age, NYHA class III-IV, brain natriuretic peptide (BNP) elevation, hospitalization time and the number of drugs taken in the two groups were significantly higher than those in the single-cause group, while those in the multi-cause group were significantly higher than those in the double-cause group (age F=53.05, P<0.01; cardiac function class χ2=15.83, P<0.01; brain natriuretic peptide χ2= 18.58, P<0.01). Hospitalization time F=28.61, P<0.01; medication type F = 18.81, P<0.01; hospitalization mortality increased with the increase of etiology, but no statistical difference was found (χ2=1.823, P=0.twin). Conclusion: The heart failure with multiple etiological factors in seniors are many with advanced age with comorbid diseases. The state of an illness and its treatment were complication as well as the hospital stays were prolonged with a poor prognosis. 2018 Vol. 24 (9): 1512-1514 [Abstract] ( 72 ) HTML (1 KB)  PDF (1321 KB)  ( 174 ) 1515 Correlation between the Endoscopic Grade of Active UC and Pathological Characteristics ZHANG Haitao, SUN Hao, LI Kai, et al DOI: 10.3969/j.issn.1006-6233.2018.09.029 Objective: To investigate the correlation between the endoscopic endoscopic grade of active UC and pathological characteristics. Methods: The clinical data of 130 UC patients admitted to our hospital in May 2014 to 2017 in May were retrospectively analyzed. Lympus CF-H260I electronic colonoscopy was used for examination. Results: Activity grading of active UC under electronic enteroscopy: 30 patients with grade I, 50 patients with grade II, 24 patients with grade III, 26 patients with grade IV. Scope of lesion: rectum 11 cases, rectosigmoid 35 cases, left colon 10 cases, right colon 11 cases, regional 3 cases, total colon 15 cases, left distal colorectal 45 cases. The proportion of diffuse inflammation and non-diffuse inflammation in different endoscopic activity classes was significantly different (P<0.05), and the proportion of diffuse inflammation in different endoscopic activity classes was higher than that in non-diffuse inflammation. Inflammation of different grade endoscopic activity of ulcerative colitis were significantly different(P<0.05). The incidence of endoscopic activity of ulcerative colitics /Ulcerative, the crypt disorder, cryptitis, recess abscess in grade Ⅳ were higher than other grade , and had no statistical significance.(P>0.05). There was difference in diminution of goblet cell and the incidence of abnormal hyperplasia of glands(P<0.05),and grade Ⅳ was significantly higher than other grade.(P<0.05)The endoscopic grade of active UC was related to AI,ESR,frequency of bloody stool, loody purulent stool(P<0.05),And has no relationship with Hb, albumen. Conclusion: Endoscopic features of active UC: the activity was mainly grade IV and grade II, and the lesion was mainly located in the left distal colon and rectum. Endoscopic activity was correlated with pathological features, and was correlated with AI, ESR, the degree and frequency of mucous bloody stool. 2018 Vol. 24 (9): 1515-1518 [Abstract] ( 76 ) HTML (1 KB)  PDF (1344 KB)  ( 193 ) 1519 Comparative Study on Intracavitary Laser and Conventional Surgery in Varicose Veins ZHAO Dandan DOI: 10.3969/j.issn.1006-6233.2018.09.030 Objective: To compare venous luminal laser and traditional surgery in the great saphenous vein in the clinical efficacy. Methods: 90 patients with varicose veins were selected as the subjects. Ninety patients were randomized to 45 patients and 45 controls. The observation group was treated with intravenous laser therapy, the control group to the great saphenous vein ligation + segmental stripping treatment. The observation and evaluation index of the system: Intraoperative,; postoperative pain and recurrence rate of one year; postoperative complications; symptoms improved. Results: ①The operation time, intraoperative blood loss and postoperative hospital stay were significantly lower in the observation group(t=9.57, 12.54, 8.62, P<0.05); ②The number of postoperative pain and recurrence in the observation group were significantly lower than those in the control group(χ2=9.24,P<0.05); ③The postoperative complications were significantly less than those in the control group(χ2=8.95,P<0.05); ④The postoperative complications were significantly less than those in the control group(χ2=9.75, P<0.05); ⑤There was no significant difference in the quality of life score between the two groups before treatment (t=1.13, P>0.05). After treatment, the two groups had significant improvement compared with before treatment (t=16.74, 22.74, P<0.05); The post-observation group improved more significantly than the control group (t=13.48, P<0.05). Conclusion: Intravenous luminal laser surgery is superior to traditional surgical treatment. It is a minimally invasive treatment method with simple operation, mild pain, quick recovery, less operative complications, low recurrence rate, safe and effective. 2018 Vol. 24 (9): 1519-1521 [Abstract] ( 72 ) HTML (1 KB)  PDF (1311 KB)  ( 109 ) 1522 Application of Ureteroscope and Percutaneous Nephroscope in Patients with Renal Calculi and its effects on Renal Function, Coagulation Function and Oxidative Stress Products XIANG Qin, LIU Yueguang, LI Wenke, et al DOI: 10.3969/j.issn.1006-6233.2018.09.031 Objective: To analyze the application effect of ureteroscope and percutaneous nephroscope in patients with renal calculi and its effects on renal function, coagulation function and oxidative stress products. Methods: The clinical data of 628 patients with renal calculi from January 2013 to October 2017 admitted in our hospital were retrospectively analyzed. According to the treatment methods, all the patients were divided into 487 control groups and 141 research groups. The control group was treated with percutaneous nephroscope and the research group was treated with ureteroscope. Then surgical effect, renal function, coagulation function and oxidative stress products, complications occurred between two group was compared. Results: The operative time in the study group was longer than that in the control group, and the amount of bleeding and hospitalization time in the study group were less than those in the control group (P<0.001). There was no difference in stone clearance between the two groups (P>0.05). 12h and 24h after operation, kidney function level in both group was increased, while research groups was lower than control group,there were significant differences in renal function between the two groups, between different time points and between groups. The difference was statistically significant (P<0.001). K and R in two group were both decreased,α and MA all increased, range of change in research groups was lower than control group (P<0.001). MDA in both group was increased, SOD and GSH-Px in both group was decreased, while the range of changein research groups was lower than control group, there were significant differences in oxidative stress productbetween the two groups, between different time points and between groups. The difference was statistically significant (P<0.001). Total adverse reaction rate in two group between the two groups was no difference (P>0.05). Conclusion: The effect of ureteroscopy and percutaneous nephrolithotomy in the patients with renal calculi diameter <20mm is similar, but the ureteroscopy has less effect on renal function, coagulation function and oxidative stress. It is more invasive and can be used as the first choice for such patients. 2018 Vol. 24 (9): 1522-1526 [Abstract] ( 94 ) HTML (1 KB)  PDF (1357 KB)  ( 332 ) 1527 Meta Analysis of Risk Factors for Intracranial Infection after Craniocerebral Injury in China WANG Kunpeng, WANG Weixing, YANG Jie, et al DOI: 10.3969/j.issn.1006-6233.2018.09.032 Objective: To explore risk factors for intracranial infection after craniocerebral injury surgery, and provided the theory basis for clinical treatment and prevention. Methods: The Chinese knowledge network, VIP, Wan Fang, CBM, and PubMed database were retrieved, and a case-control study on the related risk factors of intracranial infection after craniocerebral injury in China was retrieved from the establishment of each database to July 2016. The quantitative and comprehensive analysis of the risk factors was carried out by a fixed or random model. Results: A total of 14 case-control studies, 7969 patients had been brought into study. Meta analysis results showed that: ≥45 years old[ORthe combineOR=1.49,95%CI(1.14~1.94), P =0.003], preoperative GCS<8 [ORthe combineOR=2.53,95%CI(1.09~5.84),P=0.037], serum albumin<35g/L [ORthe combineOR=3.56,95%CI(1.27~9.96), P =0.02], operation time＞4 hours [ORthe combineOR=3.47,95%CI(1.96~6.13),P<0.0001], external ventricular drainage [ORthe combineOR=1.93,95%CI(1.00~3.72), P<0.00001], cerebrospinal fluid leakage [ORthe combineOR=5.15,95%CI(2.17~12.24), P=0.0002] and operation more than once were all risk factors for intracranial infection after craniocerebral injury surgery, the difference has statistically significance (P<0.05). The influence factor of open craniocerebral injury [ORthe combineOR=1.02, 95%CI(0.50~2.11),P=0.95], blood glucose≥7mmol/L [ORthe combineOR=3.25, 95%CI(0.49~21.31), P=0.22] has no statistically significance(P＞0.05). Conclusion: The age was≥45 years old, GCS<8, ALB<35g/L, operation time＞4 hours, external ventricular drainage, cerebrospinal fluid leakage, operation more than once were high risk factors for intracranial infection after craniocerebral injury surgery. Positive prevention and treatment should be carried on the clinical guidance for high-risk patients to reduce mortality and improve prognosis. 2018 Vol. 24 (9): 1527-1531 [Abstract] ( 88 ) HTML (1 KB)  PDF (1837 KB)  ( 226 ) 1532 Comparison of Left Ventricular Function and Myocardial Infarction Range in Patients with Myocardial Infarction by Three-Dimensional and Two-Dimensional Echocardiography WANG Weifang, HAO Hong, DING Zhichao DOI: 10.3969/j.issn.1006-6233.2018.09.033 Objective: To compare the value of three-dimensional and two-dimensional echocardiography in the evaluation of the left ventricular function and the range of myocardial infarction (MIS) in patients with myocardial infarction. Methods: 42 patients with acute myocardial infarction (AMI) were used as the research group, according to MIS size, they were divided into small MIS group and large MIS group, 32 cases healthy persons taken physical examination were used as the control group. The results of single photon emission computed tomography (SPECT) examination were the gold standard, used the Pearson correlation to analyze the value of two-dimensional and three-dimensional echocardiography in the detection of left ventricular end systolic volume (LVESV), left ventricular end diastolic volume (LVEDV), left heart stroke volume (LVSV) and left ventricular ejection fraction (LVEF) for the left ventricular function evaluation, and the value of two-dimensional global longitudinal peak strain (GLS), the whole radial peak strain (GRS), the whole circumferential peak strain (GCS) and the three dimensional total area peak strain (GAS) for the evaluation of MIS, and the 2-D global longitudinal peak strain (GLS), the whole radial peak strain (GRS), the whole circumferential peak strain (GCS) and the three dimensional total area peak strain (GAS), GLS, GRS and GCS for the MIS evaluation value, the ROC curve is used to analyze the discriminating values of the two-dimensional and three-dimensional strain values to the large and small MIS respectively. Results: The correlations between three-dimensional echocardiography and SPECT in the detection of LVESV, LVEDV, LVSV and LVEF were high (r=0.596~0.764), were significantly better than those between two-dimensional echocardiography and SPECT in the detection of left ventricular function parameters (r=0.378 ~ 0.512). The two-dimensional and three-dimensional ultrasonic strain values had high correlation with MIS (r=0.569~0.786), the correlation of two-dimensional GLS was the highest. The ROC curve showed that both the two-dimensional and three-dimensional strain values could distinguish the MIS size, the two-dimensional GLS had the maximum area under the curve (AUC), when the diagnostic threshold was 13.06%, the sensitivity was 79.86%, the specificity was 94.78%. Conclusion: Three-dimensional echocardiography has better effect on evaluating left ventricular function in patients with myocardial infarction, while two-dimensional GLS has better effect in assessing MIS size. 2018 Vol. 24 (9): 1532-1536 [Abstract] ( 113 ) HTML (1 KB)  PDF (1450 KB)  ( 315 ) 1537 Efficacy Analysis on Diagnosis and Clinical Application of X-ray CT and MRI of Cervical Spondylosis LI Xiaohui, MAO Cuiping, JIN Rui, et al DOI: 10.3969/j.issn.1006-6233.2018.09.034 Objective: To compare and analyze the clinical diagnosis of X-ray, CT, MRI diagnosis for cervical spondylosis patients. Methods: 68 cases of cervical spondylosis admitted to our hospital in December 2016 ~2017 in December were selected as research subjects. All patients were diagnosed by X-ray, CT and MRI. The results of three different diagnostic methods were compared As well as the specific signs of the situation. Results: The detection rates of patients with intervertebral space stenosis, abnormal curvature of the cervical spine, and bony stenosis using MRI were significantly higher than those diagnosed by CT. The difference between the two groups was statistically significant (P<0.05); The detection rate of intervertebral space stenosis, facet joint hyperplasia, uncinate process, bony stenosis, and vertebral body osteophytes were significantly higher than those of X-ray plain film (P<0.05). CT diagnosis hook The detection rate of sudden hyperplasia was significantly higher than that of X-ray examination. There was a statistically significant difference between groups (P<0.05). The specific signs of X-ray, CT, and MRI were respectively 35.29% (24/68), 23.53% (16/68), and 11.76% (8/68). The ratio of specific signs detected by X-ray film significantly higher than the MRI detection rate, the difference between the groups was statistically significant (P<0.05). Conclusion: The detection rate of CT diagnosis and MRI diagnosis of cervical spondylosis is higher than that of X-ray plain film. Clinical diagnosis of cervical spondylosis with CT diagnosis or MRI diagnosis can effectively improve the clinical diagnosis effect of cervical spondylosis, and has a high clinical diagnostic value. 2018 Vol. 24 (9): 1537-1539 [Abstract] ( 73 ) HTML (1 KB)  PDF (1323 KB)  ( 169 ) 1540 Influnce of Gatifloxacin on Urinary Tract Infection and Its Effect on Serum PCT IL-2 and IL-8 WANG Qi, et al DOI: 10.3969/j.issn.1006-6233.2018.09.035 Objective: To explore the effect of gatifloxacin in treatment urinary tract infection and its effect on serum PCT, IL-2 and IL-8. Methods: 122 patients with urinary tract infection who received therapy from June 2016 to December 2017 in two hospitals, according to the simple random number table method, those patients were divided into the control group and the research group, 61 cases in each group. control group was treated with levofloxacin, and the research group was treated with gatifloxacin. Then clinical efficacy, symptom relief time, the level of serum PCT, IL-2 and IL-8, and adverse reactions between two group was compared. Results: Total effective rate and bacterial clearance rate in research group was higher than that of the control group (P<0.05). the urinary tract pain, urinary frequency, and urgency relief time in research group was lesser than those in the control group, and there were statistically significant differences (P<0.05). Before treatment, serum PCT, IL-2 and IL-8 in two group was no statistically significant difference (P>0.05). After treatment, the levels of serum PCT and IL-8 in two group was decreased, and the level of IL-2 was significantly increased, and the changes of the research group were more obvious, there are statistically significant differences (P<0.05). adverse reactions in two group were mainly rash, dizziness and gastrointestinal discomfort, Adverse reaction rate in two group was no statistically significant (P>0.05). Conclusion: Effect of gatifloxacin in treatment urinary tract infection is sure, and can regulate the expression of serum PCT, IL-2 and IL-8, and reduce clinical symptoms, which may be a reliable solution for clinical treatment. 2018 Vol. 24 (9): 1540-1543 [Abstract] ( 86 ) HTML (1 KB)  PDF (1335 KB)  ( 185 ) 1544 Comparison of Transurethral Resection of Bladder Tumor and Green Laser in the treatment of Bladder Urothelial Carcinoma LI Yong, XU Zhigang, et al DOI: 10.3969/j.issn.1006-6233.2018.09.036 Objective: To compare the clinical efficacy of transurethral resection of bladder tumor and selective green laser in the treatment of bladder urothelial carcinoma. Methods: 78 patients with non invasive invasive bladder urothelial carcinoma (NMIBC) treated in our hospital were selected as the study subjects. They were divided into two groups according to the different treatment methods,electro cutting group and laser group, 39 cases in each group,transurethral resection of bladder tumor was performed in the transurethral resection group,the patients in the laser group were treated with selective green laser.The intraoperative, postoperative and adverse reactions were compared between the two groups; No recurrence, overall survival, and overall survival were analyzed within 3 years using Kaplan-Meier retention analysis. Results: The operation time, blood transfusion rate, obturator nerve reflex and perforation in the operation group were higher than those in the laser group, but the difference was not statistically significant (P>0.05). The amount of bleeding in the laser group and the amount of irrigation after operation were lower than those in the cut group, indwelling time of catheter and the length of hospital stay were shorter than those of electric cutting group, the difference was statistically significant (P<0.05).The incidence of adverse reactions in the electric cutting group (35.89%) was higher than that in the laser group (28.21%),the main adverse reactions include frequent urination, urgency, dysuria, hematuria, nausea, vomiting, fever, there was no significant difference between different types (P>0.05).The survival rate in the 3 year group (89.74%) was lower than that in the laser group (94.87%), the recurrence rate (25.64%) was higher than that of laser group (10.26%), the difference was not statistically significant (P>0.05).The average recurrence time of the electric cutting group was higher than that of the laser group, the difference was statistically significant (P<0.05).There was no significant difference between the two groups in the relapse free survival curve and the overall survival curve(χ2=0.629,P=0.428;χ2=0.58,P=0.445). Conclusion: Selective green laser treatment of bladder urothelial carcinoma is less traumatic, less bleeding, less clinical adverse reaction and low recurrence rate. The effect is better than traditional urethral resection of urinary bladder tumor. It is an effective method for the treatment of bladder urothelial carcinoma. 2018 Vol. 24 (9): 1544-1547 [Abstract] ( 91 ) HTML (1 KB)  PDF (1414 KB)  ( 174 ) 1548 Changes Analysis of Inflammatory Factors in Chronic Obstructive Pulmonary Disease with Different Phenotypes LV Jianguo, ZHAO Hailian, XU Wenbin, et al DOI: 10.3969/j.issn.1006-6233.2018.09.037 Objective: To observe the level of inflammatory factors in patients with chronic obstructive pulmonary disease, and to analyze the correlation between the level of inflammatory cytokines and the lung function. Methods: Patients with chronic obstructive pulmonary disease (COPD) hospitalized in our hospital in May 2013 to Oct. 2015 were selected as objects. The levels of inflammatory cytokines in COPD patients with different phenotypes were observed, and the correlation between inflammatory cytokines and pulmonary function was analyzed. Results: There were significant differences in IL-17 levels among COPD patients with different phenotypes: frequent acute exacerbation phenotype, emphysema type, FEV1 rapid decline type, and the difference was statistically significant (P<0.05); The COPD level of the patients with acute exacerbation of IL-8 was higher than that of the patients with emphysema, and the patients with emphysema type were higher than those of FEV1 patients, and the difference was statistically significant (P<0.05); There were significant differences in CRP levels among COPD patients with different phenotypes: frequent acute exacerbation phenotype, emphysema type, FEV1 rapid decline type, and the difference was statistically significant (P<0.05). Conclusion: The levels of inflammatory cytokines were significantly different among COPD patients with different phenotypes, and were closely related to lung function. 2018 Vol. 24 (9): 1548-1550 [Abstract] ( 95 ) HTML (1 KB)  PDF (1316 KB)  ( 176 ) 1551 Correlation Analysis of the Relationship between Plasma Ferritin Concentration and Serum Microelement Contents and Children with Febrile Seizures DU Xiaoying, LI Li DOI: 10.3969/j.issn.1006-6233.2018.09.038 Objective: To explore the correlation analysis of the relationship between plasma ferritin concentration, serum zinc, copper, selenium and magnesium content in the children with febrile seizures. Method: From April 2014 to February 2017, 158 children with febrile seizures were enrolled in this study. 96 healthy children in our hospital were selected as the control group. The levels of plasma zinc, copper, selenium and magnesium in all children were measured. The fever of the children in the observation group, the frequency of convulsions, the duration of each convulsion and 2 weeks of seizures recurrence were recorded. The children in the observation group were subjected to systemic treatment, treatment and antipyretic treatment until the hyperthermia and convulsions disappeared. Results: The blood zinc levels in the observation group were significantly lower than those in the control group (P<0.05), but there was no significant difference between the two groups in blood copper, serum selenium and blood magnesium. Compared with the control group, the plasma ferritin concentration, serum iron concentration and hemoglobin concentration were significantly smaller in the observation group, but there was no significant difference between the red blood cell count and the control group in the observation group. There were significant differences in plasma ferritin abnormalities and blood zinc abnormalities between children with different febrile seizures (P<0.05). There were no significant differences in blood copper, blood selenium and blood magnesium abnormalities (P>0.05). Conclusion: Plasma ferritin and blood zinc levels are associated with the incidence and recurrence of febrile seizures in children. To maintain iron and zinc levels in a timely manner, attention should be paid to the prevention and control of febrile seizures. 2018 Vol. 24 (9): 1551-1553 [Abstract] ( 88 ) HTML (1 KB)  PDF (1314 KB)  ( 180 ) 1554 Observation of the Clinical Effects of Vindesine and Conventional Dose Glucocorticoid on Patients with Immune Thrombocytopenic Purpura DENG Lili DOI: 10.3969/j.issn.1006-6233.2018.09.039 Objective: To discuss the effects of vindesine and conventional dose glucocorticoid on patients with immune thrombocytopenic purpura. Methods: 50 patients with immune thrombocytopenic purpura were divided into the observation group (n=25) and the control group(n=25), the control group were treated with conventional dose glucocorticoid, the observation group were treated with vindesine and conventional dose glucocorticoid. And the effective rate, PLT levels before and 4 weeks after the treatment, adverse reaction were contrasted between the two groups. Results: The effective rate was 75.0% in the observation group, significantly higher than 48.0% in the control group (P<0.05). PLT was significantly higher 4 weeks after the treatment than before (P<0.05); the PLT in the observation group was significantly higher in the observation group than the control group4 weeks after treatment (P<0.05). There was no significant difference in the adverse reactions between the two groups (P>0.05). Conclusion: Vindesine and conventional dose glucocorticoid has exactly effects in the treatment of patients with immune thrombocytopenic purpura. And it can increase the level of PLT, some patients can achieve long-term remission, and without serious adverse reactions, and the security is high. 2018 Vol. 24 (9): 1554-1556 [Abstract] ( 92 ) HTML (1 KB)  PDF (1314 KB)  ( 348 ) 1561 Application of Protective Constraint Clinical Pathway Nursing in Patients with Craniocerebral Injury and Restlessness in Department of Neurosurgery LI Lihua, et al DOI: 10.3969/j.issn.1006-6233.2018.09.041 Objective: To explore the application of protective constraint clinical pathway nursing in patients with craniocerebral injury and restlessness in mental surgery. Methods: 70 cases of craniocerebral injury restless nursing care in our hospital from 1 to April 2018 were selected as the study samples, and the equal scores were divided by random number table method. The number of study samples from the clinical nursing path group and the traditional nursing group were 35 cases, and the correlation observation of the two groups of research samples after the different protective nursing care was observed. The difference degree of the standard were observed. Results: The incidence of restlessness and constraint related nursing adverse events in the clinical pathway nursing group was lower than that of the traditional protective nursing group. The protective quality control score and the nursing satisfaction rate were higher than those of the traditional protective group (P<0.05). Conclusion: With the clinical path nursing mode, the protective management of the nursing objects of craniocerebral injury restless nursing was carried out, which could win the improvement of the protective quality of nursing care, reduce the risk of undesirable nursing events related to the agitation and restriction of the high risk nursing objects, and the satisfaction was high. 2018 Vol. 24 (9): 1561-1563 [Abstract] ( 81 ) HTML (1 KB)  PDF (1317 KB)  ( 159 ) 1564 Clinical Observation on Wuzi Mingmu Recipe Combined with Acupuncture and Moxibustion Therapy in the Treatment of Retinitis pigmentosa ZHOU Xianlin, KONG Lin DOI: 10.3969/j.issn.1006-6233.2018.09.042 Objective: To investigate the clinical effects of Wuzi Mingmu recipe combined with acupuncture and moxibustion in the treatment of retinitis pigmentosa (RP). Methods: 54 cases of RP patients (108 eyes) treated between June 2015 and June 2017 were divided into the treatment group and the control group by random number table method, each with 27 cases (54 eyes). The two groups were given western medicine, and the treatment group was given Wuzi Mingmu recipe combined with acupuncture and moxibustion on this basis. The clinical efficacy was compared in the two groups, and the visual field (mean light sensitivity, mean defect), hemorheology (whole blood viscosity, plasma viscosity, fibrinogen, erythrocyte aggregation index) and electroretinogram b wave (latency time, amplitude) were evaluated before treatment and after 8w of treatment. Results: After 8w of treatment, the clinical efficacy in the treatment group was better than that in the control group (P<0.05). After 8w of treatment, the mean light sensitivity of the two groups was significantly higher than that before treatment (P<0.05) while the mean defect was lower than that before treatment (P<0.05), and the change degree in the treatment group was higher that in the control group (P<0.05). After 8w of treatment, the hemorheology indexes (whole blood viscosity, plasma viscosity, fibrinogen, erythrocyte aggregation index), and the b wave latency times of dark adaptation and light adaptation in the treatment group were lower than those before treatment (P<0.05) and those in the control group at the same period (P<0.05) while the b wave amplitudes of dark adaptation and light adaptation were higher than those before treatment and in the control group at the same period (P<0.05), and there was no statistical significance in the levels of hemorheology indexes and the amplitude and latency time of b wave in the control group before and after treatment (P>0.05). Conclusions: Wuzi Mingmu recipe combined with acupuncture and moxibustion can have good efficacy in the treatment of RP, and it is beneficial to improve the visual acuity and visual field of patients. 2018 Vol. 24 (9): 1564-1567 [Abstract] ( 63 ) HTML (1 KB)  PDF (1329 KB)  ( 153 ) 1568 Qizhizhu Decoction Combining with Valsartan in the Treatment of Increment of UALB in DN for 29 Cases ZHANG Xia DOI: 10.3969/j.issn.1006-6233.2018.09.043 Objective: To study the effect of the increment of UALB in the early stage of DN by means of traditional Chinese and western medicine. Methods: The treatment group was treated with Qizhizhu decoction combined with Valsartan for diabetic nephropathy and the control group was treated with Valsartan for 4 weeks. The microalbuminuria improvement of two groups were compared. Results: The study showed that the microalbuminuria in the treatment group was significantly higher than that in the control group (P<0.01). Conclusion: The effect of Qi Zhi Tang Decoction Combined with valsartan on early diabetic microalbuminuria increased significantly. 2018 Vol. 24 (9): 1568-1570 [Abstract] ( 101 ) HTML (1 KB)  PDF (1244 KB)  ( 162 ) 1571 Changes and Significance of Ultrasonography in the 7th Week of Pregnancy of Spontaneous Abortion Patients MO Xiumei DOI: 10.3969/j.issn.1006-6233.2018.09.044 Objective: To study Changes and significance of ultrasonography in the 7th week of pregnancy of spontaneous abortion patients. Methods: 150 pregnant women in our hospital from February 2014 to February 2016 were selected. And all pregnant women were 7 weeks old and underwent vaginal ultrasonography. According to the pregnancy outcome, 70 patients with spontaneous abortion were set as the observation group, and 80 patients with non-spontaneous abortion were set as the control group. Collect compared two groups of pregnant women 6 weeks, 7 weeks, 8 weeks of fetal heart rate (FHR), average sac diameter (MGSD), calculation of the hip (CRL) and long average gestation sac diameter - top hip ratio (MGSD/CRL) and compare two groups of patients with clinical indicators. Results: There was no significant difference between the two groups of age and gestational age. Observation group of beta human chorionic gonadotropin (beta HCG) and progesterone levels significantly lower than the control group, uterine spiral artery blood flow parameters (RI) is significantly higher than the control group, the differences were statistically significant (P<0.05); The FHR in the observation group was significantly lower than the control group at week 6, week 7 and week 8, and the difference was statistically significant (P<0.05); The MGSD of the observation group was significantly lower than the control group in week 6, week 7 and week 8, and the difference was statistically significant (P<0.05). There was no significant difference in CRL differences between the two groups at week 6, week 7 and week 8 (P>0.05). The MGSD /CRL in the observation group was significantly lower than the control group in week 6, week 7 and week 8, and the difference was statistically significant (P<0.05). Conclusion: Ultrasonic examination of pregnant women's fetal heart rate, average diameter of the capsule, the average diameter of gestation sac - the ratio of top to hip length, beta -HCG and RI have a high evaluation value in spontaneous abortion, and the intervention measures should be taken according to the individual condition of pregnant women. 2018 Vol. 24 (9): 1571-1573 [Abstract] ( 75 ) HTML (1 KB)  PDF (1316 KB)  ( 176 ) 1574 Analysis on Risk Factors of Premature Ovarian Failure in Women of Middle Age ZHANG Xiaojing, DING Feng, LI Haijiao DOI: 10.3969/j.issn.1006-6233.2018.09.045 Objective: To investigate the risk factors of premature ovarian failure (POF) in women of middle age. Methods: 100 cases of premature ovarian failure women who received treatment in our hospital from February 2015 to February 2017 were selected as the subjects, and 100 healthy women were selected as the control group. The differences of ABO blood group, menstrual cycle and type A behavior and personality between the two groups were observed, and the factors influencing the incidence of POF were analyzed. Results: The irregular menstrual cycle, type A personality and BMI was 24kg/m2 higher incidence of premature ovarian failure (χ2=42.473, 15.394, 8.515, P<0.05), and different age, the incidence of POF in female ABO blood group had no significant difference; Age, menstrual cycle, ABO blood type, type A personality and BMI as independent variables, the occurrence of premature ovarian failure as the dependent variable, Logistic regression analysis, the results in menstrual cycle regularity and type A personality into the regression equation, the OR values were 5.361 and 4.985; The incidence of POF in patients with premature ovarian failure is positively correlated with menstrual cycle and type A behavioral personality (r=0.613, 0.598, P=0.012, 0.008), but not significantly related to ABO blood type. Conclusion: Irregular menstrual cycle and type A personality are risk factors for premature ovarian failure in women of the right age. 2018 Vol. 24 (9): 1574-1576 [Abstract] ( 75 ) HTML (1 KB)  PDF (1320 KB)  ( 207 ) 1577 Analysis on Monitoring Results of Foodborne Pathogens in Fuxin in 2014 to 2016 DU Bo, XIU Min, REN Yanyan, et al DOI: 10.3969/j.issn.1006-6233.2018.09.046 Objective: To understand the pollution of food borne pathogens in food in Fuxin, analyze the pollution of food borne pathogens in different food categories and different sampling links, and provide scientific basis for monitoring and evaluation of food safety risk in the region. Methods: According to the inspection method of the national food pollution and harmful factor risk monitoring manual, 424 samples were collected in -2016 in 2014 to detect common foodborne pathogenic bacteria, such as Salmonella. Results: 89 positive samples were detected, the total detection rate was 21%, the detection rate of Pseudomonas aeruginosa was the highest, the detection rate was 100% (6/6), followed by 43 strains of Bacillus cereus, the detection rate was 34.1% (43/126), 30 strains of Lester bacteria were detected, the detection rate was 17% (30 / 177), and 8 strains of Vibrio parahaemolyticus were detected. The detection rate was 12.7%. (8 /63) 2 strains of Enterobacter sakazakii were detected, with a detection rate of 4.4% (2 /45). The detection rate of pathogenic bacteria in food service was significantly higher than that in circulation (χ2=5.97, P<0.05), and the detection rate of pathogenic bacteria in bulk (simple package) was significantly higher than that of pre packaged food (χ2=6.22, P<0.05). Conclusion: Pseudomonas aeruginosa in direct drinking water has a certain food safety risk to residents'drinking water hygiene. Bacillus cereus contamination in rice and other flour products is serious. Food borne infant food contaminated by Enterobacter sakazakii is also a high-risk food. Supervision should be strengthened. 2018 Vol. 24 (9): 1577-1581 [Abstract] ( 58 ) HTML (1 KB)  PDF (1340 KB)  ( 206 ) 1582 Comparison of the Predictive Value of KIM-1 and Cys-C for Different Degrees of Renal Injury in Unilateral Obstructive Nephropathy GUO Li, et al DOI: 10.3969/j.issn.1006-6233.2018.09.047 Objective: To compare the predicting value of urine Kidney injury molecule-1 (KIM-1) and serum Cystatin-C(Cys-C)for levels of unilateral injury in obstructive renal disease. Methods: 92 patients with unilateral obstructive nephropathy were selected as the subjects. According to the glomerular filtration rate, the patients were divided into mild injury group, moderate injury group, severe injury group, and healthy people as control group. Blood and urine samples were collected on an empty stomach in the morning. Enzyme-linked immunosorbent assay (ELISA) was used to detect urine KIM-1. Cys-C, serum creatinine (Scr) and urea nitrogen (BUN) were detected in the laboratory. The results were compared and analyzed with GFR. Results: The expression of urinary KIM-1 in the control group was lower than that in the patients (P<0.05), and in the mild injury group was lower than that in the moderate and severe injury group (P<0.05), but there was no significant difference between the moderate and severe injury groups (P>0.05). Cys-C, Scr and BUN had no significant changes in each group. Cys-C, Scr and BUN had no significant correlation with GFR. Conclusion: Compared with Cys-C, Scr and BUN, urinary KIM-1 has potential clinical value in predicting renal injury and degree of injury in unilateral obstructive nephropathy. 2018 Vol. 24 (9): 1582-1584 [Abstract] ( 80 ) HTML (1 KB)  PDF (4567 KB)  ( 180 )

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