Home  |  About Us  |  Editorial Board  |  Instruction  |  Subscribe  |  Advertisement  |  Messages  |  Contact Us  |  中文

Office Online         Journal Just Accepted Current Issue Archive Advanced Search Most Read Most Download Email Alert            Download More...              Links More...

2018 Vol. 24, No. 8 Published: 2018-08-20 1233 Study on Somatic Proteins from Trichinella Spiralis Muscle Larvae on Apoptosis of H446 Small cell Lung Cancer Cells and C-kit Expression PAN Jingdan, YU Li, LI Dan, et al DOI: 10.3969/j.issn.1006-6233.2018.08.001 Objective: To investigate the effect of apoptosis of somatic proteins from Trichinella spiralis muscle larva on small cell lung cancer H446 cells and correlation of C-kit expression. Methods: The H446 cells were divided into groups, somatic proteins of Trichinella spiralis muscle larva as experiment group, cis-platinum(DDP) as positive control group and untreated cells as negative control group. The effects of somatic protein and DDP on the proliferation activity of H446 cells were detected by MTT colorimetry; the cell apoptosis rate of H446 cells were induced by somatic proteins and DDP by flow cytometry(FCM) respectively; the transcriptional level of C-kit mRNA and protein expression of C-kit protein were detected by Real time PCR and Western Blot method respectively. Results: The results of MTT detection showed that the proliferation of H446 cells decreased with the increase of the concentration of insect body protein and the prolongation of the time of H446 cells, and the insect body protein had a significant inhibitory effect on H446 cells, showing a dose time effect. Flow cytometry showed that somatic proteins and DDP could induce apoptosis of H446 cells. Real time PCR and Western Blot showed that the transcriptional level of C-kit mRNA and protein expression of C-kit protein were decreased of somatic proteins group and DDP group respectively, compared with negative control group. Conclusion: The somatic protein of Trichinella spiralis muscle larvae can inhibit the growth of H446 cells and induce apoptosis of H446 cells. C-kit gene may be one of the molecular targets for the treatment of small cell lung cancer. 2018 Vol. 24 (8): 1233-1236 [Abstract] ( 66 ) HTML (1 KB)  PDF (1703 KB)  ( 187 ) 1237 Effects of TIMP-1 on Invasion Migration and Secretion of VEGF Level in Villous Trophoblast Cells HOU Cui, ZHENG Yan, TANG Xiaoxia DOI: 10.3969/j.issn.1006-6233.2018.08.002 Objective: To study the effect of TIMP-1 on the invasion, migration and secretion of VEGF in the villous trophoblast cells. Methods: Anoxic reoxygenation was used to treat HTR8/SVneo in the villous trophoblastic cells; the expression of TIMP-1 in cells was detected by fluorescence quantitative PCR and Western blot, transfection of TIMP-1 siRNA in HTR8/SVneo cells, after the anoxia and reoxygenation treatment, the expression of TIMP-1 in cells was detected by fluorescence quantitative PCR and Western blot; the effects of low TIMP-1 on the migration and invasion of anoxic reoxygenated HTR8/SVneo cells were detected in the Transwell compartment; Western blot assay was used to detect the level of MMP-9 protein, the content of VEGF, sFlt-1 and sEng in the supernatant of the culture liquid was detected by ELISA. Results: The level of TIMP-1 mRNA and protein in HTR8/SVneo cells after anoxic reoxygenation was higher than that of cells without anoxic reoxygenation (P<0.05). The transfection of TIMP-1 siRNA in cells can reduce the expression of TIMP-1 in the hypoxic and reoxygenation cells. The invasion and migration of HTR8/SVneo cells decreased after anoxic reoxygenation, the level of MMP-9 protein in the cells decreased, the cell secretion of VEGF decreased, and the number of sFlt-1 and sEng increased. Compared with the cells without anoxic reoxygenation, the difference was statistically significant (P<0.05). Down regulation of TIMP-1 can promote the invasion and migration of HTR8/SVneo cells under hypoxia and reoxygenation, promote the expression of MMP-9 in cells, Inducing cells to secrete VEGF, decrease the secretion of sFlt-1 and sEng in cells. Conclusion: Down regulation of TIMP-1 promoted the invasion and migration of villous trophoblastic cells under hypoxia and reoxygenation, and promoted the secretion of VEGF by cells. 2018 Vol. 24 (8): 1237-1241 [Abstract] ( 52 ) HTML (1 KB)  PDF (1552 KB)  ( 144 ) 1242 Expression of Soluble Co-stimulatory Molecule B7-H4 in Serum of Patients with Precancerous Lesions of Esophagus CHEN Xinran, et al DOI: 10.3969/j.issn.1006-6233.2018.08.003 Objective: To study the expression of soluble costimulatory molecule B7 homologue 4 (sB7-H4) in sera of patients, in order to investigate the clinical significance of sB7-H4 in the diagnosis of esophageal precancerous condition. Methods: Esophageal pathological changes were evaluated by hematoxylin-eosin (HE) staining. sB7-H4 and squamous cell carcinoma antigen-2 (SCCA-2) concentrations were detected by enzyme-linked immunosorbent assay (ELISA). Results: The precancerous lesions of the esophagus were divided into low grade intraepithelial neoplasia (LGIN) and high grade intraepithelial neoplasia (HGIN). The serum SCCA-2 concentration in HGIN patients was significantly higher than that in LGIN patients and healthy subjects (SCCA-2, P<0.01, P<0.01). The serum sB7-H4 concentration in LGIN patients was significantly higher than that in healthy subjects (sB7-H4) (P<0.05), and significantly lower than that in HGIN patients (P<0.01). The expression of sB7-H4 in serum was positively correlated with the histopathological grade of esophagus (P<0.0001), but not related to age and sex (P=0.7777, P=0.6068). Conclusion: The concentration of serum sB7-H4 increased progressively in the course of precancerous lesions of the esophagus. sB7-H4 is a valuable serum marker for judging the progression of precancerous lesions. 2018 Vol. 24 (8): 1242-1244 [Abstract] ( 77 ) HTML (1 KB)  PDF (1693 KB)  ( 177 ) 1245 Screening and Identification of EPHA2 Gene in Congenital Cataract LI Qian, et al DOI: 10.3969/j.issn.1006-6233.2018.08.004 Objective: To investigate the pathogenesis gene in a family with autosomal dominant congenital cataracts (ADCC) by target rejoin capture sequencing. Methods: A three-generations Chinese family with ADCC were recruited and all patients underwent comprehensive ophthalmic examinations. Target rejoin capture sequencing was performed on the proband, then the sequencing results were compared with the data of human genomic database, the synonymous mutation was filled after reported common variants. Sanger sequencing was used to validate co-segregation of the candidate variant in the family. The impact on the amino acid sequences and the conservation of the variant were further analyzed. Results: Seven patients were found in this family, the patients were distributed in each generation with equal incidence rates in male and female subjects. Target rejoin capture sequencing found a heterozygous mutation c.1532C>T (p.T511M) in EPHA2(ephrin typeA receptor2), which was highly conserved among various species and resulted in an abnormal EPHA2 protein. Then the Sanger sequencing showed co-segregation of the mutation in the family. Conclusion: EPHA2 gene c.1532C>T (p.T511M) may be a pathogenic mutation in the family of congenital cataract. 2018 Vol. 24 (8): 1245-1248 [Abstract] ( 134 ) HTML (1 KB)  PDF (1880 KB)  ( 195 ) 1249 Effect the Study of Recombinant Human Brain Natriuretic Peptide Combined with Xinmailong Injection on Serum Apelin-12 D-dimer and Cardiac Function in Patients with Cardiac Valve Replacement HUANG Lihua, HOU Xiuwei, LI Wei DOI: 10.3969/j.issn.1006-6233.2018.08.005 Objective: To study the influence of recombinant human brain natriuretic peptide combined with Xinmailong injection on serum Apelin-12, D-dimer and cardiac function in patients with cardiac valve replacement. Methods: 80 patients with mitral valve replacement who received therapy from Aug. 2015 to Aug. 2017 in our hospital were selected as research objects, according to random number table, those patients were divided into the observation group (n=40) and the control group (n=40), they were given routine treatment after operation, the control group was treated with Xinmailong injection, while the observation group was combined with recombinant human brain natriuretic peptide. The perioperative condition, serum N-terminal pro brain natriuretic peptide (NT-proBNP), serum Apelin-12, D-dimer, left ventricular ejection fraction (LVEF), creatine kinase isoenzyme (CK-MB), troponin I (cTnI) and incidence of postoperative adverse events were compared between the two groups. Results: The mechanical ventilation time, ICU time and the hospitalization time in the observation group were significantly shorter than those in the control group(P<0.05). The NT-proBNP of two groups were significantly lower than those before the operation (P<0.05), and the NT-proBNP in the observation group was significantly lower than those in the control group (P<0.05). The serum Apelin-12, D-dimer of two groups were significantly higher than those before the operation (P<0.05), and the serum Apelin-12, D-dimer in the observation group was significantly lower than those in the control group (P<0.05); after the operation, the LVEF of two groups were significantly lower than those before the operation, and the CK-MB and cTnI were significantly increased (P<0.05), and the LVEF in the observation group was significantly higher than those in the control group, the CK-MB and cTnI was significantly lower than those in the control group (P<0.05); 1 months after operation, there was no significant difference in the incidence of infection and hypoglycemia between the two groups (P>0.05), the incidence of atrial fibrillation and thrombus in the observation group was significantly lower than those in the control group 2.50%(1/40)vs 15.00%(6/40),2.50%(1/40)vs 17.50%(7/40) (P<0.05). Conclusion: The effect of recombinant human natriuretic peptide combined with heart injection after cardiac valve replacement is significant, and it has protective effect on cardiac function, and can reduce the incidence of atrial fibrillation and thrombus after operation. The internal mechanism may be related to the effective control of the elevation of serum Apelin-12 and D- two polymer. 2018 Vol. 24 (8): 1249-1253 [Abstract] ( 77 ) HTML (1 KB)  PDF (1346 KB)  ( 136 ) 1254 Efficacy of Dexamethasone combined with Ursodeoxycholic Acid in Clinical treatment of Intrahepatic Cholestasis of Pregnancy and its Effects on Level of PLTP IL-18 LI Hua, ZHANG Liping, GAO Xia, et al DOI: 10.3969/j.issn.1006-6233.2018.08.006 Objective: To study curative efficacy of dexamethasone combined with ursodeoxycholic acid in treatment of intrahepatic cholestasis of pregnancy and its effects on level of PLTP,IL-18. Methods: 130 patients with intrahepatic cholestasis of pregnancy treated in our hospital from Oct. 2014 to Oct. 2016 were selected and divided into the observation group and the control group according to different treatment methods. The patients in observation group were treated with dexamethasone and deoxycholic acid, while the patients in control group were treated with dexamethasone. Then the clinical effect, serum levels of PLTP and IL-18, pruritus score and pregnancy outcomes in the two groups were observed and compared before and after the treatment. Results: After treatment, the total efficacy of observation group was 93.8%, which was obviously higher than that of the control group (80.0%, P<0.05); After treatment, the serum levels of PLTP and IL-18 in the observation group were significantly lower than those of the control group (3.17±0.33) pg/mL vs (4.47±0.49) pg/mL; (58.03±6.02) ng/mL vs (68.86±7.11) ng/mL)(P<0.05); After treatment, the levels of ALT, AST and TBIL, and pruritus score of observation group were significantly lower than those of the control group(P<0.05). There was no statistically significant difference in the incidence of premature birth, fetal distress and neonatal asphyxia between the two groups (P>0.05). The cesarean section rate in the observation group was significantly lower than that of the control group, and the apgar score was higher (P<0.05). Conclusion: The clinical efficacy of dexamethasone combined with ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy is significantly better than that of dexamethasone alone. It can effectively improve the liver function and pregnancy outcome, and reduce the level of serum PLTP and IL-18. 2018 Vol. 24 (8): 1254-1257 [Abstract] ( 89 ) HTML (1 KB)  PDF (1321 KB)  ( 167 ) 1258 The Effect of Huoxue Tongyu Decoction combined with TCM Syndrome Differentiation in the treatment of Patients with Ovulatory Infertility ZHU Lei, CHEN Yi, DING Fangling, et al DOI: 10.3969/j.issn.1006-6233.2018.08.007 Objective: To observe the clinical effect of Huoxue Tongyu decoction combined with TCM syndrome differentiation in the treatment of patients with ovulatory infertility. Methods: 98 patients with ovulatory infertility in our hospital from Feb. 2016 to Apr. 2017 were selected as the study objects, and they were randomly divided into control group and observation group, with 49 cases in each group. The control group was treated with western medicine, and the observation group was treated with Huoxue Tongyu decoction combined with TCM syndrome differentiation. The oviposit rates and pregnancy rates of different duration of disease, diameter of follicle and the thickness of endometrium before and after the treatment of two groups were compared. Results: The oviposit rates and pregnancy rates of observation group with different duration of disease were all higher than those of control group, the differences were statistically significant (P<0.05). The diameter of follicle and the thickness of endometrium of two groups before the treatment were compared, and the differences were not statistically significant (P>0.05). The diameter of follicle and the thickness of endometrium of observation group were all higher than those of control group, the differences were statistically significant (P<0.05). Conclusion: The clinical effect of Huoxue Tongyu decoction combined with TCM syndrome differentiation in the treatment of patients with ovulatory infertility is better, and it can significantly improve the oviposit rate and pregnancy rate. 2018 Vol. 24 (8): 1258-1260 [Abstract] ( 94 ) HTML (1 KB)  PDF (1295 KB)  ( 124 ) 1261 Expression and Significance of Homocysteine Glycosylated Hemoglobin and Glial Fibrillary Acidic Protein in Patients with Acute Ischemic Stroke ZHANG Nan, JIA Yonghua, JI Qiling, et al DOI: 10.3969/j.issn.1006-6233.2018.08.008 Objective: To study the expression and significance of homocysteine (Hcy), glycosylated hemoglobin (HbAlc), glial fibrillary acidic protein (GFAP) in acute ischemic stroke patients. Methods: 80 patients of acute ischemic stroke received therapy from Oct. 2015 to Oct. 2016 in our hospital were selected as observation group, in the same period, 80 healthy people who received medical examination in our hospital were selected as the control group. Enzyme linked immunosorbent assay (ELISA) was used to detect the expression of Hcy, HbAlc and GFAP in all subjects, the expression of Hcy, HbAlc and GFAP in patients with acute ischemic stroke with different infarct level, different severity of disease and different prognosis were compared, and the relationship between Hcy, HbAlc, GFAP and acute ischemic stroke was analyzed. Results: The Hcy, HbAlc and GFAP in the observation group were significantly higher than those in the control group (P<0.05); the expression of Hcy, HbAlc and GFAP increased with the increase of infarct size and the severity of the disease, and the difference was significantly different (P<0.05); the Hcy, HbAlc and GFAP in the poor prognosis group were significantly higher than those in the good prognosis group (P<0.05); the Pearson correlation analysis showed that there was a positive correlation between Hcy, HbAlc, GFAP and the degree of National Institutes of Health Stroke Scale (NIHSS) scores and the area of cerebral infarction (P<0.05); and in Logistic regression, Hcy, HbAlc, and GFAP are all risk factors affecting the prognosis of patients with acute ischemic stroke (P<0.05). Conclusion: Hcy, HbAlc and GFAP are independent risk factors that affect the degree and prognosis of acute ischemic stroke, it can be used as an important indicator of diagnosis, treatment and evaluation of the disease, and it is of high value in clinical application. 2018 Vol. 24 (8): 1261-1265 [Abstract] ( 109 ) HTML (1 KB)  PDF (1341 KB)  ( 121 ) 1266 Relationship between Serum FGF21 Level and Serum Thyroid Hormone Levels and Bone Metabolic Parameters in Patients with Abnormal Thyroid Function ZHANG Yanyan, WU Jun DOI: 10.3969/j.issn.1006-6233.2018.08.009 Objective: To investigate the level of serum FGF21 in patients with abnormal thyroid function, so as to discuss the relationship between FGF21 and thyroid hormones and bone metabolism. Methods: 64 hyperthyroid patients (hyperthyroidism group), 31 hypothyroid cases (hypothyroidism group) and 57 healthy controls (control group) were recruited in this investigation. FT3, FT4, TSH, ALP, FGF21, and BGP were detected. Results: Compared with the control group, FT3, FT4, OPN, TRACP, BALP, BGP, β-CTX decreased, while increased in hyperthyroidism group, meanwhile, TSH and FGF21 increased in hypothyroidism group and decreased in hyperthyroidism group, the differences were statistically significant (F=336.60, 278.79, 72.32, 47.95, 22.71, 283.51, 17.54, 19.22, 19.91, P<0.05); FGF21 in three groups negatively correlated with OPN, TRACP, BALP, BGP and β-CTX (r=-0.531, -0.614, -0.346, -0.425, -0.391, -0.412, -0.406, -0.316, -0.346, -0.298, - 0.528, -0.606, -0.391, -0.447, -0.385, P<0.05). Conclusion: In patients with hyperthyroidism, the increased serum levels of FT3, FT4 and decreased level of TSH make the FGF21 significantly inhibited, resulting in an increase in the expression of bone metabolism index and the loss of bone mass. The above index in patients with hypothyroidism is the opposite. 2018 Vol. 24 (8): 1266-1269 [Abstract] ( 79 ) HTML (1 KB)  PDF (1464 KB)  ( 148 ) 1270 Clinical Value of PNI/CRP in Predicting the Prognosis Outcome of Patients with Hip Fracture after Operation JI Jinwei, YOU Xiaojun, YANG Liangdong, et al DOI: 10.3969/j.issn.1006-6233.2018.08.010 Objective: To explore the predictive value of prognostic nutrition index (PNI)/C-reactive protein (CRP) ratio (PNI/CRP) in the prognosis of hip fracture patients. Methods: 83 cases of hip fractures treated in our hospital were involved. The general data, majeed scores, the serum type I procollagen amino propeptide (PINP), osteocalcin (BGP), bone alkaline phosphatase(BALP), PNI, CRP, PNI / CRP and other indicators of all patients were measured and recorded. A follow-up period of 12 months was applied. Patients who died during follow-up were defined as having a poor prognosis, and the remaining patients were defined as having a good prognosis. After the end of follow-up, the potential factors that may affect the patient's prognosis were collated and analyzed and their predictive value was analyzed. Results: At the end of follow-up, 46 patients had a good prognosis (good prognosis group) and 31 patients died (poor prognosis group). Cox single & multivariate regression analysis found that PNI (P = 0.013, RR = 0.768) and PNI / CRP (P = 0.003, RR = 0.216) were independent predictors of poor surgical outcome in patients with hip fractures. ROC curve analysis found that the area under the curve (AUC) of PNI/CRP was the best, 0.887, the best diagnostic point was 10.84, the sensitivity was 64.52%, and the specificity was 97.83%. Conclusion: PNI/CRP has a good ability to predict the prognosis of patients with hip fracture after operation, and it is expected to be one of the indexes for clinical evaluation of prognosis risk of hip fracture patients. 2018 Vol. 24 (8): 1270-1272 [Abstract] ( 92 ) HTML (1 KB)  PDF (1350 KB)  ( 205 ) 1273 Effect of Nimodipine Combined with Donepezil Hydrochloride on Cognitive Impairment and Quality of Life in Patients with Cerebral Infarction WANG Jianfeng, ZHANG Chenhong, WANG Wan, et al DOI: 10.3969/j.issn.1006-6233.2018.08.011 Objective: To study the effect of Nimodipine combined with donepezil hydrochloride on cognitive impairment and quality of life in patients with cerebral infarction. Methods: 82 patients of cognitive impairment after cerebral infarction who received therapy from Jan. 2016 to Dec. 2016 in our hospital were selected. According to random number table, The patients were divided into the observation group and the control group, 41 cases of each group. Patients in the control group were treated with donepezil hydrochloride, and patients in the observation group were treated with nimodipine on this basis. The clinical efficacy and NIHSS score, Montreal Cognitive Assessment Scale (MoCA) score, motor function scale (Fugl-meyer score) and adverse reactions were compared between the two groups before and after treatment. Results: After treatment, the clinical efficiency of the observation group was significantly higher than that of the control group 92.68%(38/41) vs 73.17% (30/41) (P<0.05); The NIHSS score in observation group was significantly lower than that in control group (3.87±1.33) vs (5.56±1.85) score (P<0.05); The MoCA score in observation group was significantly higher than that in control group (26.53±5.71) vs (22.02±5.47) score (P<0.05); The Fugl-meyer score in observation group was significantly higher than that in control group (84.57±6.13) vs (73.13±6.02) score (P<0.05); The total incidence of adverse reactions in observation group was lower than that in control group 14.63% (6/41) vs 41.46% (17/41) (P<0.05). Conclusion: Nimodipine combined with donepezil hydrochloride is effective in the treatment of cognitive impairment of cerebral infarction. It can obviously improve the nerve defect, cognitive function and motor function of the patients, and improve the quality of life of the patients with high safety. The effect is better than the use of donepezil alone. It is worthy of application. 2018 Vol. 24 (8): 1273-1276 [Abstract] ( 97 ) HTML (1 KB)  PDF (1319 KB)  ( 370 ) 1277 Expressions and Significance of Th17 Treg Cell and Related Cytokines in Peripheral Blood in Patients with SLE JIA Huiyu, CHENG Guanghui DOI: 10.3969/j.issn.1006-6233.2018.08.012 Objective: To explore the expressions and significance of Th17, Treg, and related cytokines in peripheral blood in patients with SLE. Methods: A total of 65 patients with SLE admitted in our hospital from May 2016 to April 2017 were included in the study and divided into the activity group (n=33) and the non-activity group (n=32) according to SLEDAI. Moreover, 25 healthy individuals who came for physical examinations were served as the control group. The fasting peripheral venous blood was collected. The scattering velocity immunoturbidimetry was use to detect the serum IgA, IgG, IgM, C3, C4 levels. FCM was used to detect the expressions of Th17 and Treg. ELISA was used to detect the expressions of IL-6, IL-17, IL-23, and TGF-β. Results: IgA, IgG, and IgM in the activity group were significantly higher than those in the non-activity group and the control group, while C3 and C4 were significantly lower than those in the non-activity group and the control group. IgA and IgG in the non-activity group were significantly higher than those in the control group. Th17 and Th17/Treg in the activity group were significantly higher than those in the non-activity group and the control group, while Treg was significantly lower than that in the non-activity group and the control group. Th17 and Th17/Treg in the non-activity group were significantly higher than those in the control group, while Treg was significantly lower than that in the control group. IL-6, IL-17, and IL-23 in the activity group were significantly higher than those in the non-acitivity group and the control group, while TGF-β was significantly lower than that in the non-acitivity group and the control group. IL-6, IL-17, and IL-23 in the non-activity group were significantly higher than those in the control group. Conclusion: The expressions of peripheral blood Th17, Treg, and related cytokines in patients with SLE are abnormally expressed, and correlated with the disease activity, sugessting that Th17/Treg imbalance plays a vital role in the pathogenesis of SLE. 2018 Vol. 24 (8): 1277-1280 [Abstract] ( 100 ) HTML (1 KB)  PDF (1326 KB)  ( 176 ) 1281 Cox Regression Analysis of the Risk Factors of Severe Incisional Hernia after Renal Transplantation XIAO Zhaolan, FU Junming, WU Chenguang, et al DOI: 10.3969/j.issn.1006-6233.2018.08.013 Objective: To understand the occurrence of severe incisional hernia after renal transplantation and analyze the risk factors that affect the occurrence of it. Methods: Retrospective analysis of the clinical data of 827 patients who underwent the allograft kidney transplantation from Aug. 2005 to Aug. 2015, according to the occurrence of severe incisional hernia after operation, They were divided into incisional hernia group and non incisional hernia group, including 25 cases of incisional hernia group and 802 cases of non incisional hernia groups, the clinical data and renal transplantation data of the two groups were compared, and the factors that affected the severe incisional hernia after renal transplantation were analyzed by Cox multiple factor regression analysis. Results: ①In this study, 25 cases of postoperative severe incisional hernia occurred in 827 patients with renal transplantation, the incidence rate was 3.02%. ②The difference between the incisional hernia group and non incisional hernia group was not statistically significant in age, gender, chronic kidney disease history, diabetes and hypertension before transplantation, steroid induced diabetes, first transplantation, organ donation type, operation time, senior surgeon, fascia closure suture, the way of closing the abdomen, incision hernia history and peritoneal dialysis history (P > 0.05), there was a statistically significant difference in body mass index (BMI), smoking, abdominal operation history, surgical incision, incision infection, postoperative low albumin, postoperative taking immunosuppressive agents and lymphatic cyst after transplantation between the two groups (P < 0.05). ③Multivariate Cox multiple factor regression analysis showed that obesity, smoking and lymphatic cyst after transplantation were independent risk factors for severe incisional hernia after renal transplantation. Conclusion: Obesity, smoking and lymphatic cysts after transplantation are independent risk factors for severe incisional hernia after renal transplantation. 2018 Vol. 24 (8): 1281-1284 [Abstract] ( 72 ) HTML (1 KB)  PDF (1302 KB)  ( 144 ) 1285 Comparison of Predicting Value of the prognostic of Plasma BNP and PCT in Elderly Patients with Severe Pulmonary Infection SHEN Yan, QIN Xiaojuan DOI: 10.3969/j.issn.1006-6233.2018.08.014 Objective: To compare the plasma brain natriuretic peptide (BNP) and procalcitonin (PCT) on the predictiveprognosis value of elderly patients with severe pulmonary infection. Methods: 78 cases of elderly patients with severe pulmonary infection as the study group were selected in our hospital, and 78 cases of elderly patients with general pulmonary infection were selected at the same period as the control group. Thelevels of plasma BNP and PCTbefore treatment, 1 day, 3 days and 7 days after treatment were measured of the two groups, and thepredictiveprognosis value of plasma BNP and PCT inelderly patients with severe pulmonary infection was analyzed. Results: Theplasma BNP level in the study group before treatment was significantly higher than in the control group and the PCT level was also significantly higher than in the control group, which showed that the differences were statistically significant (both P<0.05). Theplasma BNP and PCT levels 3 days and 7 days after treatment of those who improved in the study group were significantly lower than in the deterioration persons, which showed that the differences were statistically significant (all P<0.05). The area under ROC curve in BNP for evaluation the prognosis of patients was 0.43, with sensitivity of 0.72 and the specificity of 0.56; the area under ROC curve in PCT for evaluation of the prognosis of patients was 0.92, with the sensitivity of 0.81 and the specificity of 0.92. Conclusion: Compared with plasma BNP, PCT in the predictiveprognosis value ofelderly patients with severe pulmonary infection is higher, which show thesensitivity and specificity for prognosis are high those in BNP, so it can be used as an important indicator to evaluate the prognosis of elderly patients with severe pulmonary infection. 2018 Vol. 24 (8): 1285-1288 [Abstract] ( 63 ) HTML (1 KB)  PDF (1472 KB)  ( 324 ) 1289 Anesthetic Effect of Lumbar Plexus Sciatic Nerve Block Anesthesia on Upper Femoral Fracture and Its Effects on Heart Rate and Blood Pressure During Operation Anesthesia YAN Jianxin, LIU Chunming DOI: 10.3969/j.issn.1006-6233.2018.08.015 Objective: To study the femoral fractures in the upper lumbar plexus anesthesia operation-the effect of sciatic nerve block and the effects on the heart rate, blood pressure. Methods: 110 cases of upper femoral fracture of the Department of orthopedics in our hospital in February -2018 February 2017 were selected and all patients were divided into two groups according to the random number method, the control group and the study group, each of the n=55 cases. The control group was treated with combined spinal epidural anesthesia, and the study group received lumbar plexus sciatic nerve block anesthesia. The onset time, duration and duration of motor and sensory nerve block were recorded in the two groups. The patients' heart rate blood pressure and visual analogue scale (VAS) before and after operation, were recorded for the two groups to compare their effects. Results: After anesthesia, there was no significant difference in onset time and improvement time between the two groups (P > 0.05). The duration of motor block in the study group was significantly lower than that in the control group, while the duration of sensory nerve block was significantly longer than that in the control group (P<0.05). There was no significant difference in HR, SBP and DBP scores between the control group and the study group before anesthesia (P > 0.05). The HR in the study group was significantly lower than the control group (P<0.05) at the beginning of the operation (P < 0.05). All the SBP and DBP were higher than those in the control group (P < 0.05). The results of visual analogue assessment (VAS) showed that the VAS scores in the control group were significantly higher than those in the study group (P < 0.05) in the first day and third day after the operation. Conclusion: The anesthesia effect of combined lumbar plexus and sciatic nerve block in the operation of the upper femoral fracture is good. It can not only meet the requirements of operation anesthesia, but also have less influence on the circulation and respiration and it is worthy of should be further applied in clinical practice. 2018 Vol. 24 (8): 1289-1292 [Abstract] ( 68 ) HTML (1 KB)  PDF (1304 KB)  ( 154 ) 1293 Clinical Efficacy of Transanal Microsurgery in the Treatment of Rectal Tumor and Its Effects on Serum IL-2 IL-6 and TNF-α Levels YAO Yuan, LI Qingke, MA Guoming, et al DOI: 10.3969/j.issn.1006-6233.2018.08.016 Objective: To study the clinical efficacy of transanal microsurgery in the treatment of rectal tumor and its effects on the serum IL-2, IL-6 and TNF-α levels. Methods: A retrospective analysis of 68 cases of rectal cancer admitted from February 2014 to December 2015 in our hospital was carried out. The patients were divided into 2 groups by operation method, 34 cases in each group. The control group was treated with traditional rectal cancer radical resection (Miles operation), while the observation group was treated with transanal microsurgery. The perioperative condition, preoperative anorectal function score, serum IL-2, IL-6 and TNF- alpha levels and postoperative complications of the two groups were compared. Results: The operation time, anal exhaust time, feeding time, hospitalization time of observation group were significantly shorter than those of the control group, the amount of bleeding was significantly less than that of the control group (P<0.05). After surgery, the anorectal function score of observation group was significantly lower than that of the control group (P<0.05), the serum IL-2 level of observation group was significantly higher than that of the control group, and the serum IL-6 and TNF-α levels were significantly lower than those of the control group (P<0.05); the total incidence of urethral injury, infection, anastomotic leakage and encopresis of observation group was significantly lower than that of the control group(P<0.05). Conclusion: The application of transanal microsurgery in the treatment of rectal tumor patients is significant. It can help to promote postoperative recovery, and has less effect on serum IL-2, IL-6, TNF- a, and is safe and worthy of application. 2018 Vol. 24 (8): 1293-1296 [Abstract] ( 65 ) HTML (1 KB)  PDF (1305 KB)  ( 118 ) 1297 Curative Efficacy of Pramipexole Combined with Benserazide Tablets in treatment of Parkinson's Disease and Effects on Serum BDNF 5-HT and NE ZHANG Binbin, HOU Yu, LOU Wei DOI: 10.3969/j.issn.1006-6233.2018.08.017 Objective: To study curative efficacy of pramipexole combined with benserazide tablets in treatment of parkinson's disease and effects on serum brain derived neurotrophic factor(BDNF), 5-serotonin (5-HT) and norepinephrine (NE) level. Methods: 100 patients of parkinson's disease who received therapy from June 2015 to June 2017 in our hospital were selected as research objects, according to random number table, those patients were divided into the observation group (n=50) and the control group (n=50). The control group was treated with benserazide tablets, while the observation group was combined with pramipexole. All the patients were treated continuously for 12 weeks. The clinical effects, Parkinson's unified score scale (UPDRS) score, serum BDNF, 5-HT, NE and adverse reactions of two groups were compared. The clinical effects of two groups were compared with the Parkinson unified score scale (UPDRS), and the enzyme linked immunosorbent assay was used to detect serum BDNF, 5-HT and NE, and the adverse reactions of the two groups were recorded. Results: After treatment, the total effective rate of clinical efficacy in the observation group was 94% (47/50), which was significantly higher than that of the control group 76% (38/50) (P<0.05); after treatment, the scores of UPDRS I, UPDRSⅡ, UPDRS Ⅲ, UPDRS Ⅳ and UPDRS total score of two groups were significantly lower than those before treatment (P<0.05), and the scores of UPDRS I, UPDRSⅡ, UPDRS Ⅲ, UPDRS Ⅳ and UPDRS total score in the observation group were significantly lower than that of the control group (P<0.05); after treatment, the serum BDNF, 5-HT and NE in the two groups were significantly higher than those before the treatment (P<0.05), and the serum BDNF, 5-HT and NE in the observation group were significantly higher than that of the control group (P<0.05); there was no significant difference in the incidence of nausea, vomiting, sleeplessness, upper abdominal discomfort and visual abnormality during the treatment of the two groups (P>0.05). Conclusion: Pramipexole combined with benserazide tablets is well for parkinson's disease, which can effectively improve the clinical effect, and its internal mechanism may be related to the increase of the expression of serum BDNF, 5-HT and NE. 2018 Vol. 24 (8): 1297-1300 [Abstract] ( 77 ) HTML (1 KB)  PDF (1323 KB)  ( 174 ) 1301 Analysis of the Application Effect of Glucocorticoids in the Treatment of Children with Refractory Pneumonia and Mycoplasma Pneumonia SONG Xiaotong DOI: 10.3969/j.issn.1006-6233.2018.08.018 Objective: To investigate the effect of glucocorticoids in the treatment of children with refractory pneumonia and mycoplasma pneumonia. Methods: 200 children with refractory pneumonia and mycoplasma pneumonia admitted from February 2016 to February 2018 were randomly divided into two groups. The control group was given routine treatment. The glucocorticoid group was given glucocorticoids. Hormones, hospital-related indicators, lung function, inflammatory markers, immune parameters, imaging findings, and adverse reactions were compared between the two groups. Results: The time of fever, total fever, cough remission, total cough time, antibiotic use time, and number of relapses were significantly lower in the glucocorticoid group than in the control group; FVC, FEV1, PEF, and FEF25 after treatment. , FEF75, IgG, CD3+/CD4+ and CD3+/CD8+ levels were significantly higher than the control group, WBC and CRP levels were significantly lower than the control group; overall imaging examination results were significantly better than the control group, the difference has Statistical significance (P<0.05); There was no statistically significant difference in drug adverse reaction rate between the two groups of children (P>0.05). Conclusion: The application of glucocorticoids in the treatment of children with refractory pneumonia caused by mycoplasma pneumonia is effective, with high safety and useful for reference. 2018 Vol. 24 (8): 1301-1303 [Abstract] ( 71 ) HTML (1 KB)  PDF (1295 KB)  ( 143 ) 1304 Efficacy and Mechanism Analysis of Linezolid combined with Cyclosporine Capsule and Levofloxacin in the treatment of Drug-resistant Pulmonary Tuberculosis ZHANG Mengtao, XU You, MA Jinbao DOI: 10.3969/j.issn.1006-6233.2018.08.019 Objective: To discuss the clinical efficacy of linezolid combined with serine capsule and levofloxacin in the treatment of drug-resistant pulmonary tuberculosis. Methods: 78 cases of drug-resistant pulmonary tuberculosis treated in our hospital in May 2014 -2016 May were studied. According to the difference of the medication scheme, the patients were divided into the observation group (39 cases) and the control group (39 cases). The patients in the control group were treated with serine and levofloxacin on the basis of the national standard pulmonary tuberculosis treatment. The observation group was treated with linezolid on the basis of the control group. The therapeutic effects, serum levels of TNF-alpha, PCT, TOS, TAS and PON1 of the two groups were compared. Results: The effective rates of the observation group and the control group were (87.18%, 66.67%, P<0.05) respectively. After treatment, the absorption time, cavity closure time, acid fast staining negative time and sputum culture negative time in the observation group were shorter than those in the control group (P<0.05). Compared with before treatment, the levels of serum TNF- alpha, PCT and TOS in the two groups were significantly decreased, while the levels of TAS and PON1 were increased, and the changes of the above indexes were higher in the observation group (P<0.05). Conclusion: The clinical effect of linezolid combined with cycine serine capsule and levofloxacin in the treatment of drug-resistant tuberculosis is significant. It can significantly improve the clinical symptoms and shorten the turning time of sputum tuberculosis bacilli. It is worthy of clinical application. 2018 Vol. 24 (8): 1304-1307 [Abstract] ( 311 ) HTML (1 KB)  PDF (1301 KB)  ( 864 ) 1308 The Application of Double Microcatheter Technique in the Interventional Treatment of Intracranial Wide Necked Aneurysm HUANG Huadong, LUO Kunxiang, FU Huangde, et al DOI: 10.3969/j.issn.1006-6233.2018.08.020 Objective: To explore the effect of double catheter technique in the interventional treatment of intracranial wide necked aneurysms. Methods: 42 patients with intracranial wide necked aneurysms admitted in our hospital from January 2013 to March 2016 were selected as the subjects. According to the difference of treatment methods, all the patients were divided into two groups: the observation group and the control group. The observation group was treated by double micro catheter intervention, and the control group was treated with stent assisted therapy. The time of two groups of hospitalization and the neurological deficit (NIHSS) score, living activity (ADL) score, Glasgow prognosis score, and the incidence of complications after 6 months after treatment were observed. Results: There was no significant difference in NIHSS scores and ADL scores between the two groups (P > 0.05); The good recovery rate of the two groups was equal (P>0.05). There was no significant difference in mortality, survival rate and disability rate (P>0.05). The incidence of complications in the observation group (14.29%) was lower than that in the control group (33.33%), P<0.05. Conclusion: Double microcatheter technique and stent assisted embolization are effective in the treatment of intracranial wide necked aneurysms, but double microcatheter interventional therapy can reduce the incidence of complications. 2018 Vol. 24 (8): 1308-1309 [Abstract] ( 64 ) HTML (1 KB)  PDF (1278 KB)  ( 154 ) 1310 Effect Observation of Vitreous Injection of Compaq combined with Total Retinal Photocoagulation on Progressive Diabetic Retinopathy CHANG Yan DOI: 10.3969/j.issn.1006-6233.2018.08.021 Objective: To investigate the effect of intravitreal injection of Conbercept combined with panretinal photocoagulation on the thickness of retinal nerve fiber layer (RNFL), macular thickness and visual acuity in patients with progressive diabetic retinopathy (DR). Methods: 76 patients with progressive DR were randomly divided into the experimental group and the control group, with 38 cases in each group. The former was treated by intravitreal injection of Conbercept combined with panretinal photocoagulation, while the latter was only treated with panretinal photocoagulation alone. The thickness of RNFL and macular thickness were obtained through related examinations before and after treatment. The concentration of serum vascular endothelial growth factor (VEGF) was detected, the recovery of visual acuity was evaluated, and the incidence of complications was statistically analyzed. Results: There was no significant difference in the thickness of RNFL and macular thickness between the two groups before treatment (P>0.05). However, the thickness of RNFL and macular thickness were significantly decreased after the treatment, and the average RNFL thickness of the upper, lower, temporal and nasal side ring area of the optic disc, the thickness of whole-cycle 360 degrees RNFL and macular thickness in the experimental group were significantly lower than those in the control group (P<0.05). There was no significant difference in the concentration of serum VEGF and the BCVA between the two groups before treatment (P>0.05). The concentration of serum VEGF in at the experimental group at 7d, 14d and 28d after treatment was significantly lower than that in the control group, and the increase of the BCVA was significantly greater than that in the control group (P<0.05). The incidence rates of anterior chamber inflammatory reactions, intraocular hypertension, corneal edema and neovascularization in the experimental group after treatment were slightly lower than those in the control group (P>0.05). Conclusion: Intravitreal injection of compaitcp before retinal photocoagulation helps to reduce the thickness of RNFL, macular thickness and serum VEGF concentration in progressive DR patients, thus improving visual acuity. 2018 Vol. 24 (8): 1310-1314 [Abstract] ( 61 ) HTML (1 KB)  PDF (1333 KB)  ( 176 ) 1315 Effect of Reconstruction of the Dorsal Branch of the End of the Digital Artery and Reverse Island Flap on the Sensation of the Fingertip Defect Patient AI Chengbin, et al DOI: 10.3969/j.issn.1006-6233.2018.08.022 Objective: To explore the influence of reverse island flap pedicled with terminal dorsal branch of digital artery with sense reconstruction for repairing fingertip defects. Methods: From January 2015 to December 2016, 70 patients with finger end defect were treated in our hospital. A total of 78 fingers were used for the reconstruction of the dorsal branch of the terminal dorsal branch of the finger artery. Results: In 5 cases, blisters appeared on the 7 finger-flaps in the third day after operation, healing after symptomatic treatment, the other flaps survived and woundsⅠhealed; After operation, the recovery rate of superficial sensation at 6th month was higher than that at 3rd month and 1st month, and the difference was statistically significant (100.00%, 76.92%,0.00 %,P<0.05); In the 1st month after surgery, all the patients recovered deep pain; In the postoperative 6th month, the two-point discrimination was (5.48±1.14) mm, which was significantly less than that of the postoperative 3rd month; In the postoperative 6th month, the sensory recovery of the flaps was significantly better than that of postoperative 3rd month and 1st month (P<0.05), and the ratio of S4 reached to 23.08%. Conclusion: The reconstruction of sensory end dorsal branch island flap to repair the finger end defect is an effective way to restore the sensation of the skin flap, but it takes a certain time. 2018 Vol. 24 (8): 1315-1317 [Abstract] ( 61 ) HTML (1 KB)  PDF (1300 KB)  ( 138 ) 1318 Changes in Expession Levels of Branched Chain Amino Acids NT-proBNP and Left Ventricular Function in Patients with Diabetic Cardiomyopathy CHANG Pan, ZHANG Xiaomeng, et al DOI: 10.3969/j.issn.1006-6233.2018.08.023 Objective: To investigate the changes of BCAA and NT-proBNP levels, and the correlation of left heart function in patients with diabetic cardiomyopathy. Methods: A total of 87 patients with diabetic cardiomyopathy, and 50 healthy persons who had received physical examination as control group in the corresponding period. The serum levels of BCAA and NT-proBNP level were determined. Echocardiography was taken to detect the left ventricular enddiastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), inter-ventricular septum end-diastolic thickness (IVST), left ventricular posterior wall end-diastolic thickness (LVPWT), left ventricular ejection fraction (LVEF), fraction shortening (FS) and mitral valve peak blood flow velocity E and A to calculate E/A value and Tei index. Results: Compared with the control group, the serum levels of BCAA and NT-proBNP level increased greatly, the difference was statistically significant (P>0.01), LVEDD, LVESD, FS, the A and E/A value was not statistically significant (P>0.05), while IVST, LVPWT, LVEF, the E and Tei index was statistically significant (P<0.05). In patients with diabetic cardiomyopathy, the levels of both amino acid and NT-proBNP in plasma were positively correlated with the Tei index, and the difference was statistically significant (P<0.05). Conclusion: The content of BCAA in diabetic cardiomyopathy is significantly increased and has a positive correlation with the Tei index, which provides a basis for the early diagnosis of diabetic cardiomyopathy and the progress of the disease. 2018 Vol. 24 (8): 1318-1321 [Abstract] ( 86 ) HTML (1 KB)  PDF (1306 KB)  ( 137 ) 1322 Influence Analysis of FOCUS-PDCA Circulation Management on Patients with Diabetic Nephropathy CUI Yihong, LI Jianping DOI: 10.3969/j.issn.1006-6233.2018.08.024 Objective: To investigate the effect of FOCUS-PDCA circulatory management on blood glucose and hypoglycemia during maintenance hemodialysis in patients with diabetic nephropathy. Methods: The 108 patients with diabetic nephropathy admitted from January 2013 to January 2018 in our hospital were randomly divided into 2 groups according to the random number table method, 54 cases in each group. The control group received routine care and the observation group received FOCUS-PDCA cycle management care. The fasting blood glucose levels and the incidence of hypoglycemia were compared between the two groups. Results: At the beginning of dialysis, the control of blood glucose level at 2h after dialysis and at the end of dialysis were all better than those in control group (P <0.05).The incidences of hypoglycemia in observation group 1h, 2h, 3h and 4h after dialysis were lower than those in control group Control group, the difference was statistically significant (P <0.05). Conclusion: The application of FOCUS-PDCA circulation management in maintenance hemodialysis patients with diabetic nephropathy can effectively maintain the blood glucose level and reduce the incidence of hypoglycemia, which is worthy of clinical promotion. 2018 Vol. 24 (8): 1322-1324 [Abstract] ( 74 ) HTML (1 KB)  PDF (1301 KB)  ( 228 ) 1325 Effects of Standard Large Trauma Craniotomy combined with Mild Hypothermia on Postoperative NIHSS Score and Serum S-00β and MBP Levels in Patients after Operation with Severe Craniocerebral Injury FENG Tao, HAN Bing, YE Kaihua DOI: 10.3969/j.issn.1006-6233.2018.08.025 Objective: To investigate the effects of standard large trauma craniotomy combined with mild hypothermia on postoperative NIHSS score and serum astrocyte protein (S-100β) and myelin basic protein (MBP) in patients with severe craniocerebral injury. Methods: From April 2016 to November 2017, 72 patients with severe craniocerebral injury were treated in the Department of Neurosurgery at the second people's Hospital in Dongying. The random digital table method was divided into the control group (n=36) and the study group (n=36). The control group was treated with standard large trauma craniotomy, while the study group was treated with standard large trauma craniotomy plus mild hypothermia treatment. 1 month after admission and 1 month after operation, the scores of two groups of nerve function defect (NIHSS), intracranial pressure level (1d, 2d, 3d), and the changes of serum S-100 beta and MBP levels at admission and first d after operation were compared, and the incidence of complications in two groups were compared. Results: The NIHSS scores in the two groups after treatment were lower than those before treatment, and the study group was lower than the control group, the difference was statistically significant (P <0.05); The intracranial pressure of the two groups at 1d, 2d and 3d after treatment was lower than before treatment, and the study group was lower than that of the control group at each time period, the difference was statistically significant (P <0.05); The levels of serum S-100β and MBP in the two groups after treatment were lower than those before treatment, the study group was lower than the control group, the difference was statistically significant (P <0.05); The incidence of complications in the study group was significantly lower than that of the control group (P <0.05). Conclusion: Treatment of severe craniocerebral injury using standard large trauma craniotomy combined with mild hypothermia gets a significant effect, which can effectively reduce intracranial pressure, improve neurological function, reduce serum S-100β, MBP levels, and the low incidence of complications , with higher security, worthy of promotion. 2018 Vol. 24 (8): 1325-1328 [Abstract] ( 76 ) HTML (1 KB)  PDF (1301 KB)  ( 155 ) 1329 Clinical Observation of Microscope-assisted Anterior Cervical Discectomy and Fusion in treatment of Single Segmental Cervical Spondylosis LIU Yongqiang, et al DOI: 10.3969/j.issn.1006-6233.2018.08.026 Objective: To observe the clinical efficacy of microscope-assisted anterior cervical discectomy and fusion (ACDF) in treatment of single segmental cervical spondylosis. Methods: 98 cases of single segment cervical spondylosis admitted to our hospital from February 2016 to July 2017 were selected. According to the random number table, they were divided into the control group and the research group, 48 cases and 50 cases respectively. Control group was treated with standard ACDF, research group was treated with microscope-assisted ACDF. The surgical indexes, changes of visual analogue scale (VAS), Japanese orthopaedics association (JOA) and complications of two groups before and after treatment were compared. Results: The intraoperative bleeding volume of research group was less than that of control group (P<0.05); Compared with before treatment, the VAS scores of two groups significantly decreased after treatment, but the JOA score significantly increased, and above indexes of research group were better than those of control group (P<0.05); The incidence of complications of research group was 2.00% (1/50), which compared with 8.33% (4/48) of control group, there was no statistical difference (P>0.05). Conclusion: The treatment of single cervical spondylosis with microscope assisted anterior cervical discectomy and fusion can significantly improve the clinical effect, reduce the amount of bleeding in the operation, and will not increase the complications, relieve the pain of the patients and promote the recovery of the function of the cervical vertebra. 2018 Vol. 24 (8): 1329-1331 [Abstract] ( 81 ) HTML (1 KB)  PDF (1305 KB)  ( 153 ) 1332 Effect of Hysteroscopic Combined with Uterine Artery Embolization for the Treatment of Ectopic Pregnancy after Cesarean Section and its Safety Analysis LI Na DOI: 10.3969/j.issn.1006-6233.2018.08.027 Objective: To investigate the efficacy and safety of hysteroscopic and uterine artery embolization in the treatment of cesarean scar pregnancy. Methods: 70 cases of cesarean scar pregnancy that were admitted from January 2015 to June 2017 were randomly divided into two groups. Patients in the embolization group were given traditional treatment. Hysteroscopy combined with uterine artery embolization was performed in the combined group. Comparing the perioperative indexes, adverse reactions or complication rate, lesion diameter, β-HCG level and long-term quality of life between the two groups. Results: Intraoperative blood loss (32.08±9.12), mass loss time (5.36±0.78), β-HCG negative time (4.77±0.60), menstrual recovery time (5.09±0.79) and length of stay (6.29±) 0.66) were significantly lower than the traditional group (52.43±10.85, 7.04±1.16, 5.72±0.89, 6.31±0.80, 8.03±0.71); the lesion diameter (30.44±7.07) and β-HCG levels (4720±531) after treatment Comparison between groups was significantly lower than the traditional group (36.38±7.46, 6035±712); 6 months after treatment, physiological function (71.25±8.04), role limitation (83.12±8.78), body pain (75.60±8.31), overall The difference between healthy (72.90±7.67) and vitality score (85.12±8.40) groups was significantly higher than that of the traditional group (62.47±7.95, 74.56±7.83, 67.13±8.22, 64.78±7.96, 76.45±8.70). There was a significant difference. (P<0.01); There was no significant difference in overall adverse reactions or complication rates between the two groups (P>0.05). Conclusion: Hysteroscopy and uterine artery embolization are effective and safe for cesarean scar pregnancy. 2018 Vol. 24 (8): 1332-1335 [Abstract] ( 64 ) HTML (1 KB)  PDF (1319 KB)  ( 209 ) 1336 Observation on the Clinical Efficacy of Stereotactic Minimally Invasive Surgery Combined with Piracetam and Hyperbaric Oxygen in the Treatment of Brain Tumors TANG Tao DOI: 10.3969/j.issn.1006-6233.2018.08.028 Objective: To analyze the clinical efficacy of stereotactic micro-invasive surgery combined with postoperative piracetam and hyperbaric oxygen therapy for brain tumors. Methods: 104 cases of brain tumor patients were divided into control group and observation group according to admission by random digital table method, each group of 52 cases. The control group was treated with stereotactic minimally invasive surgery. The observation group was given stereotactic minimally invasive surgery combined with piracetam and hyperbaric oxygen therapy. The quality of life score, adverse reactions, curative effect and survival rate, mortality, recurrence rate and metastasis rate during the 1-year follow-up were and compared between the two groups. Results: During treatment, the total incidence of complications in the observation group was 7.67%, The mortality, recurrence rate and metastasis rate were 11.54%, 1.92%, 1.92% during follow-up, respectively, and these were significantly lower than the control group's (21.15%, 19.23%, 13.46%, 13.46%) (all P<0.05). After treatment, the total score of the life quality in the observation group was (89.04±7.78), the total effective rate was 92.31%, and the survival rate was 90.38%, which were significantly higher than those in the control group (69.17±6.74, 78.85%, 53.85%) (all P<0.05) . Conclusion: The effect of Laci Staw and hyperbaric oxygen therapy on brain tumor patients after minimally invasive surgery is significant. It can effectively improve the quality of life, reduce the incidence of complications, and have high safety. 2018 Vol. 24 (8): 1336-1338 [Abstract] ( 74 ) HTML (1 KB)  PDF (1300 KB)  ( 339 ) 1339 Value Analysis of Four-dimensional Color Doppler Ultrasound combined with System B Ultrasound in Screening Fetal Congenital Malformations ZHANG Ling, MENG Linxia, HE Fang, et al DOI: 10.3969/j.issn.1006-6233.2018.08.029 Objective: To investigate the value of B-ultrasound in the screening of fetal congenital malformations by four-dimensional ultrasonography. Methods: 780 pregnant women who underwent physical examination in our hospital from January 2016 to January 2017 were selected as study subjects. All pregnant women was used four-dimensional color ultrasound and system B-ultrasound for the checking of fetal congenital malformations. The accuracy, sensitivity, and specificity of the two methods was compared. Results: The results of labor induction/delivery was used as the gold standard, there were 18 malformation fetuses in 780 newborns, the accuracy rate of four-dimensional ultrasonography was 94.44% (17/18), the accuracy of system B-ultrasound was 66.67% (12/18),and the difference between the two groups was statistically significant (P<0.05); The sensitivity of the two examination methods was the same, both being 100.00%. The specificity of the system B-ultrasound was 99.28%, and the specificity of the color Doppler ultrasound was 99.87%; Misdiagnosis analysis found that four-dimensional color Doppler ultrasound by pregnancy time, fetal position and amniotic fluid content greater impact, the system B-ultrasound detection accuracy lower but can be used during early pregnancy; Conclusion: The four dimensional color Doppler ultrasound and the system B ultrasound have high accuracy and sensitivity in fetal congenital malformation screening, but the two detection methods have certain defects. The combined detection method can improve the accuracy of detection, and the effect is better. 2018 Vol. 24 (8): 1339-1342 [Abstract] ( 53 ) HTML (1 KB)  PDF (1302 KB)  ( 132 ) 1343 Effect of Recombinant Bovine Basic Fibroblast Growth Factor combined with Negative Pressure Drainage on Wound Healing in Patients with Grade Ⅱ burns XIANG Guangjun DOI: 10.3969/j.issn.1006-6233.2018.08.030 Objective: To observe the clinical effect of recombinant bovine basic fibroblast growth factor (rbFGF) combined with negative pressure drainage on wound healing in patients with second degree burn. Methods: A total of 64 patients with grade Ⅱ burn from April 2016 to April 2017 in our hospital were selected for study. According to patients with different treatment methods they were divided into observation group and control group, 32 cases in each group. The control group was treated with negative pressure drainage and the observation group was treated with rbFGF and negative pressure drainage. The clinical effects of wound healing in both groups were compared. Results: The growth of superficial second-degree burns granulation in the observation group was significantly faster than that in the control group (P <0.05). The total wound granulation growth in the observation group was better than that in the control group (P <0.05). The residual wound area, wound healing time and hospital stay in the observation group were less than those in the control group after treatment (P <0.05). After 3 months of healing, a follow-up survey was conducted. All the burn wounds healed in both groups, leaving scar of different degree. Scores in the observation group were lower than those in the control group (P <0.05). Conclusions: Recombinant bovine basic fibroblast growth factor combined with negative pressure drainage is an ideal treatment for wound healing in patients with second degree burn. 2018 Vol. 24 (8): 1343-1345 [Abstract] ( 65 ) HTML (1 KB)  PDF (1299 KB)  ( 165 ) 1346 Clinical Observation of Ultrasonic Debridement Combined with Biofeedback Therapy on Postoperative Wound Healing and Recovery of Sphincter Function in Perianal Abscess JIA Guopu, LIU Xiaoli, et al DOI: 10.3969/j.issn.1006-6233.2018.08.031 Objective: To investigate the effect of ultrasound debridement therapy combined with biofeedback therapy on postoperative wound healing and sphincter function recovery of perianal abscess. Methods: 90 cases of patients underwent perianal abscess in the hospital from September 2016 to October 2017 were enrolled in this study and were randomly divided into routine treatment group, ultrasonic debridement group and ultrasonic debridement combined with biofeedback therapy group. Patients in the conventional treatment group were treated with saline debridemen, patients in Ultrasonic debridement group were given ultrasound debridement treatment, and patients in the combined group were given biofeedback on the basis of ultrasound debridement. The wound healing rate, the wound healing time, the first bacterial clearance rate and the anorectal dynamics were compared between the three groups after treatment. Results: The total effective rate in the combined treatment group was higher than that in the ultrasound group and the conventional group (P<0.05). The carrion off time, epithelial time, wound healing time of patients in ultrasonic debridement group and combined treatment group were significantly shorter than the conventional treatment group (P<0.05). inwhich the wound healing time of the combined treatment group was significantly shorter than that of the ultrasound debridement group (P<0.05). After 14 days, the scores of wound pain, secretory score, granulation score and tissue edema were significantly lower in the patients with ultrasound debridement and combination therapy than those in the conventional treatment group (P<0.05). The first bacterial clearance rates in patients with ultrasound debridement group and combination therapy group were significantly higher than that in routine treatment group (P<0.05);The first time bacterial clearance rate in the combined treatment group was significantly higher than that in the ultrasound group and the conventional group (P < 0.05). The rectal resting pressure in the combined treatment group was significantly lower than that of the other two groups, and the maximal systolic pressure, defecation and distress threshold and the maximum tolerance threshold were significantly higher than those of the other two groups (P<0.05). Conclusion: Ultrasonic debridement combined with biofeedback can effectively shorten the healing time of postoperative wound in patients with perianal abscess and improve postoperative anal rectal dynamics. 2018 Vol. 24 (8): 1346-1350 [Abstract] ( 85 ) HTML (1 KB)  PDF (1338 KB)  ( 203 ) 1351 Observation of the Effect of Metformin combined with Dimethyl -35 in the treatment of Polycystic Ovary Syndrome in Women of Childbearing Age ZHOU Lihong, MANAER·Zhumahan, LU Chunyan DOI: 10.3969/j.issn.1006-6233.2018.08.032 Objective: To investigate the curative effect of metformin combined with da-35 on polycystic ovary syndrome in women of childbearing age. Methods: 70 women of childbearing age who were admitted to hospital from January 2015 to June 2017 were randomly divided into two groups: metformin in the single drug group and up to Ying-35 in the combined group Disease-related parameters in two groups of patients, overall treatment effect, BBT biphasic rate, pregnancy outcome and safety. Results: BMI (23.40 ± 0.82), average follicular volume (7.01 ± 0.50), mean antral follicle count (5.05 ± 0.73), FINS (17.38 ± 2.75), Homa-IR (2.96 ± 0.50), LH ± 0.73), LH / FSH (0.71 ± 0.19) and TG (115.56 ± 25.18) were significantly lower than those in the single drug group (24.47 ± 0.80,7.94 ± 0.58,6.35 ± 0.90,19.41 ± 2.60,3.76 ± 0.61,6.09 ± 1.03,1.09 ± 0.20,130.44 ± 23.78), intima thickness (9.70 ± 1.09), FSH (12.36 ± 2.48) and HDL-C (72.48 ± 9.31) were significantly higher than those in the single drug group (7.07 (94.29%), bipolar rate of BBT (62.86%), ovulation (88.57%) and pregnancy rate (77.14%) were significantly different between the two groups ) Were significantly higher in single drug group (74.29%, 34.29%, 68.57%, 51.43%), there was a significant difference (P <0.05). There was no significant difference between the two groups in the adverse drug reaction rate (17.14% vs. 5.71%) (P> 0.05). Conclusion: Metformin combined with dimethyl -35 is effective and safe in the treatment of polycystic ovary syndrome in women of childbearing age. 2018 Vol. 24 (8): 1351-1353 [Abstract] ( 90 ) HTML (1 KB)  PDF (1299 KB)  ( 209 ) 1354 Clinical Efficacy Observation of Leuprolide Acetate Combined with Tibolone in the treatment of Endometriosis CHEN Rong, WANG Jun, LIU Yuehe DOI: 10.3969/j.issn.1006-6233.2018.08.033 Objective: To investigate the clinical efficacy of leuprolide combined with tibolone in the treatment of endometriosis. Methods: 80 patients with endometriosis admitted from October 2015 to October 2016 were randomly divided into two groups: leuprolide acetate group and leuprolide acetate group Boulong,. The clinical indicators, bone mineral density, overall treatment effect and Kupperman score of the two groups were compared. Results: The levels of 24wFSH (3.04 ± 0.53), LH (4.41 ± 0.73) and E2 (31.45 ± 6.33) in the combined group were significantly higher than those in the leuprolide group (2.38 ± 0.40,3.45 ± 0.70 , 25.78 ± 5.19), BGP (16.60 ± 4.17) and CA125 levels (13.27 ± 4.04) were significantly lower than those in the leuprolide group (24.17 ± 5.89 and 18.77 ± 4.60) The level of lumbar BMD at 6 months (1.085 ± 0.060) and 12 months after lumbar spine withdrawal (1.082 ± 0.061) were significantly higher than those in leuprolide group (1.035 ± 0.062,1.050 ± 0.051,1.054 ± 0.050) ; The total effective rate (87.5%) was significantly higher than that of leuprolide group (70%); after treatment, hot flashes, sweating value (5.90 ± 0.76), vulvar vaginal discomfort value (1.90 ± 0.55) (0.60 ± 0.18) and Kupperman score (7.94 ± 1.80) were lower than those in the leuprolide group (7.12 ± 0.88, 3.33 ± 1.08, 1.05 ± 0.42 and 10.77 ± 2.35 respectively), the difference was statistically significant (P <0.05). Conclusion: The clinical efficacy of leuprolide combined with tibolone in the treatment of endometriosis is significant, which can improve the safety and has reference value. 2018 Vol. 24 (8): 1354-1357 [Abstract] ( 116 ) HTML (1 KB)  PDF (1313 KB)  ( 524 ) 1358 Comparative Study of Combined Ureteroscopic Flexible Holmium Laser Lithotripsy and Percutaneous Nephrolithotomy in the treatment of Renal Calculi CHEN Chen, WANG Chen, LI Ziliang, et al DOI: 10.3969/j.issn.1006-6233.2018.08.034 Objective: To compare the clinical efficacy of combined ureteroscopic lithotripsy with holmium laser lithotripsy and percutaneous nephrolithotomy in the treatment of renal calculi. Methods: 102 patients with renal calculi from March 2016 to August 2017 in our hospital were divided into observation group (n=51) and control group (n=51) according to different surgical methods. The control group was treated with percutaneous nephrolithotomy, and the observation group was treated by combined ureteroscope and holmium laser lithotripsy. The recovery of surgery and postoperative were compared between the two groups including (operation time, intraoperative bleeding, stone clearance rate, hospitalization time), preoperative and postoperative 72h oxidative damage index malondialdehyde (MDA), superoxide dismutase (SOD), the occurrence rate of complications and quality of life score of 3 months before and after operation. Results: Operation and postoperative recovery: There was no significant difference between the two groups of operation, 96.08% (49/51) and 94.12% (48/51)) (P > 0.05). Compared with the control group, the amount of bleeding in the observation group was less and the time of hospitalization was shorter (P < 0.05). Oxidative stress injury: There was no significant difference in serum MDA and SOD levels between the observation group and the control group before operation (P > 0.05), and 72 h after operation. The level of serum MDA in the observation group was lower than that of the control group, and the level of SOD was higher than that of the control group (P < 0.05). Complications: The incidence of postoperative complications in the observation group was 1.96% (1/51), which was lower than that in the control group (15.69%) (8/51), and the difference was statistically significant (P < 0.05). Quality of life: There was no significant difference in the quality of life between the two group before operation (P>0.05); After 3 months, the quality of life score of the observation group was higher than that of the control group(P<0.05). Conclusion: Combined ureteroscopic lithotripsy with holmium laser lithotripsy and percutaneous nephrolithotomy in the treatment of renal calculi can achieve the ideal effect of gravel, but the former than the latter to the body smaller damage, less bleeding and lighter oxidative stress response, lower complication rate, which is conducive to the early rehabilitation of patients. 2018 Vol. 24 (8): 1358-1361 [Abstract] ( 57 ) HTML (1 KB)  PDF (1324 KB)  ( 171 ) 1362 Clinical Effect of Laparoscopic Surgery on Patients with Cholecystolithiasis and Choledocholithiasis LI Enzhong, XIE Fusheng, ZHANG Qian, et al DOI: 10.3969/j.issn.1006-6233.2018.08.035 Objective: To study and evaluate the clinical effects of laparoscopic surgery on patients with cholecystolithiasis and choledocholithiasis. Methods: 104 cases of cholecystolithiasis and choledocholithiasis patients in the hospital from January 2013 to December 2015 were selected as the research object, the patients were randomly divided into two groups by following by single blind random allocation principle, the control group (49 patients) received traditional open stone surgery, the observation group (55 patients) received laparoscopic cholecystectomy combined with biliary exploration, the situation of surgery, postoperative and follow-up were compared between two groups. Results: In the operation situation, the operation time in the observation group and the control group was closely (P>0.05), the incision length and intraoperative blood loss in the observation group were significantly lower than the control group (P<0.05); in the postoperative situation, the recovery time, ambulation time and hospitalization time in the observation group were significantly shortened than the control group (P<0. 05), and the complication rate was significantly lower than the control group (P<0.05); compared with the control group, the satisfaction of operation in the observation group was significantly higher (P<0.05); in follow-up situation, the recurrence rate in the observation group was significantly lower than the control group (P<0.05). Conclusions: Laparoscopic surgery treatment can effectively reduce the operation machine body hit on the patients with cholecystolithiasis and choledocholithiasis, reduce postoperative complications, is propitious to accelerate the postoperative recovery, also can reduce the relapse rate and improve the prognosis. 2018 Vol. 24 (8): 1362-1364 [Abstract] ( 52 ) HTML (1 KB)  PDF (1300 KB)  ( 167 ) 1365 Effects of Group Intervention on Mental Symptoms and Social Functions in Patients with First-episode Schizophrenia CAI Xiangming, QIU Jiancheng, WANG Lili, et al DOI: 10.3969/j.issn.1006-6233.2018.08.036 Objective: To explore the impact of group intervention model on mental symptoms and social function of patients with first-episode schizophrenia. Methods: A total of 60 cases of first-episode schizophrenia who were admitted to hospital in 2016 , were randomly divided into intervention group and control group of 30 cases. The intervention group was given the interventi- on of group model in the whole course. The social disability screening schedule (SDSS), the positive and negative syndrome scale (PANSS), drug management forms and awareness of drug knowledge and adverse reactions were assessed at admission, at 3 months and 6 months after discharge. Results: There was no significant difference in the scores of SDSS and PANSS scales between the two groups at admission (P>0.05). 3 months after discharge, the score of SDSS of intervention group was significantly lower than the control group (P<0.01); and the score of positive symptoms, general symptoms and total score in the PANSS scale was lower than the control group (P<0.05), and there was no significant difference in negative symptoms between the two groups (P>0.05). 6 months after discharge, the score of SDSS in the intervention group was significantly lower than the control group (P<0.01), and the scores of positive symptoms, negative symptoms, general symptoms and total socres in PANSS scale were all significantly lower than the control group (P<0.01). The self-management ability of the drug in the intervention group was significantly better than that of the control group at 6 months after discharge (P<0.01), and the awareness of drug knowledge and adverse reactions were also significantly higher than that of the control group (P<0.01). Conclusions: Group intervention can improve the mental symptoms of first episode schizophrenic patients and improve their daily social function, which can be used as one of the effective means of rehabilitation therapy for psychiatric patients. 2018 Vol. 24 (8): 1365-1368 [Abstract] ( 88 ) HTML (1 KB)  PDF (1318 KB)  ( 145 ) 1369 Clinical Efficacy Analysis of Vitapex Paste and Calcium Hydroxide in Treating Children's Root Induced by Pulp Necrosis ZHANG Zhihui DOI: 10.3969/j.issn.1006-6233.2018.08.037 Objective: Our study was aimed to investigate the clinical efficacy of Vitapex paste and calcium hydroxide in the application of apexification after pulp necrosis in children, in order to provide scientific basis for clinical diagnosis and treatment. Methods: The clinical data of 94 patients of pulp necrosis and 100 families of teeth treated with apexification in our hospital from January 2015 to January 2017 were selected and the 100 families of teeth were randomly divided into vitapex group(n=50) and calcium hydroxide group(n=50 ). Vitapex paste and calcium hydroxide were used to apexification. Recheck the treatments in June and December and analyze the curative effects of the two groups. Results: After 6 months of treatment, the total effective rates of X-ray films in the vitapex group and the calcium hydroxide group were 92% (46/50) and 86% (43/50), and there was no statistical difference between the two groups (χ2=0.854, P= 0.356); the clinical indexes of vitapex group and calcium hydroxide group were 94% (47/50) and 90% (45/50) respectively, there was no significant difference between the two groups (χ2 = 0.544, P = 0.461); After 12 months of treatment, the total effective rate of X-ray film in Vitapex group was 90% (45/50), which was significantly higher than that of calcium hydroxide group (70% (35/50)), and the difference was statistically significant (χ2=6.250, P = 0.012). The total effective rate of clinical indicators in the Vitapex group was 92% (46/50), which was significantly higher than that of the calcium hydroxide group (72% (36/50)),and the difference was statistically significant (χ2=6.775, P=0.009 ); The incidence of EIP in the vitapex group during the treatment was 8% (4/50), which was significantly higher than that of the calcium hydroxide group (24% (12/50), and the difference was statistically significant (χ2=4.762, P=0.029). Conclusion: Vitapex paste is superior to calcium hydroxide in the long-term efficacy of apexification by pulpal necrosis in children. 2018 Vol. 24 (8): 1369-1371 [Abstract] ( 73 ) HTML (1 KB)  PDF (1296 KB)  ( 188 ) 1372 Analysis on Predictive Factors of PCI Revascularization in Patients with Ischemic Cardiomyopathy WANG Kun, GUO Jingtao, ZHOU Jiang, et al DOI: 10.3969/j.issn.1006-6233.2018.08.038 Objective: To explore the efficacy predictors to percutaneous coronary intervention for the patients with Ischemic cardiomyopathy(ICM). Methods: 123 patients with ICM admitted in the Chengde Central Hospital from Sep,2015 to Sep,2017 underwent coronary angiography and PCI. The basic data and interventional data of the patients were collected and followed up for 6 months. The changes of various indexes before and after PCI were analyzed. Based on whether the treatment is effective, the patients were divided into two groups. Through the comparison between groups, the efficacy predictors to percutaneous coronary intervention for the patients with ICM were analyzed. Result:Among the 123 ICM patients enrolled in the study, 67 were PCI-responder and 56 were non-PCI-responder , with an effective rate of 54.47%. There were no statistically significant differences in general data between the two groups. And there were 7 indicators including sex, age, diabetes, SYNTAX score, angina pectoris, electrocardiogram V1~V4 lead Q wave, and whether left anterior descending coronary artery revascularization were correlated to the efficacy of PCI for the patients with ICM. Multivariable Logistic regression analysis showed that age(OR=0.825, 95% CI:0.813~1.157,P=0.032), diabetes(OR=0.170, 95% CI:0.042~0.643, P=0.012), angina pectoris(OR=3.982, 95% CI:0.581~14.232, P=0.008), electrocardiogram V1~V4 lead Q wave(OR=0.039, 95% CI:0.018~0.576,P=0.000), the left anterior descending coronary artery effective revascularization(OR=4.251, 95% CI:0.833~19.143,P=0.046) were the pridictors to percutaneous coronary intervention for the patients with Ischemic cardiomyopathy. Conclusion: The younger age, without diabetes mellitus, angina pectoris, electrocardiogram V1~V4 lead without Q waves, and left anterior descending coronary artery revascularization are predictors of possible benefit from PCI in patients with ICM. 2018 Vol. 24 (8): 1372-1375 [Abstract] ( 72 ) HTML (1 KB)  PDF (1321 KB)  ( 176 ) 1376 Analysis of Risk Factors for Syncope in Children with Basal Erect Tilt Test XUE Ying, AN Xinjiang DOI: 10.3969/j.issn.1006-6233.2018.08.039 Objective: To analyze the results of vertical tilt test (HUTT) and its correlation with related factors in children with vasovagal syncope(VVS). Methods: 140 cases of suspected VVS diagnosed from June 2016 to March 2017 in our hospital were selected as the subjects and HUTT examination was carried out. According to the results, the children were divided into HUTT positive group and HUTT negative group. The clinical information was analyzed by regression analysis to determine the independent risk factors of HUTT positive. Results: There were 75 cases of HUTT positive children and 65 cases of negative children. The average number of syncope in HUTT positive group was (2.34 + 1.18) times, while those in HUTT negative group were (0.74 + 0.18) times. The difference between two groups was statistically significant (t=10.818, P<0.001).The proportion of chest tightness in the HUTT positive group was 44% and the negative group of HUTT was 26.15%. The difference between the two groups was statistically significant (x 2=4.83, P=0.028); the results of univariate analysis showed that female gender (P<0.001), aged >12 years (P<0.001), number of syncope(χ2=22.918,P=<0.001)、a history of syncope pathogenesis (P=0.014), (P<0.001), family history of syncope the chest is weak (P=0.041) related factors for positive results for HUTT; Multiple factor Logistic regression analysis showed that Over 12 years of age, history of syncope, family history of syncope, number of syncope, chest tightness, fatiguewere independent risk factors for HUTT positive. Conclusion: The value of these features for the clinical diagnosis of VVS should be paid attention to in the HUTT examination, which is over 12 years old, sex female, syncope history, syncope family history and chest depression. 2018 Vol. 24 (8): 1376-1379 [Abstract] ( 106 ) HTML (1 KB)  PDF (1312 KB)  ( 220 ) 1380 Efficacy Study of Inhaled Therapy with Symbicort Turbulaler in the Treatment of Patients with Lung Cancer Complicated with Chronic Obstructive Pulmonary Disease SONG Zhonghua DOI: 10.3969/j.issn.1006-6233.2018.08.040 Objective: To explore the effect of inhaled therapy with symbicort turbulaler in the treatment of patients with lung cancer complicated with chronic obstructive pulmonary disease. Methods: 78 cases of COPD patients with lung cancer treated in the hospital respiratory department in April 2016 to June 2017 were selected as the study objects. According to the principle of random control, the patients were divided into the observation group (39 cases) and the control group (39 cases).The control group was given conventional basic treatment and symptomatic treatment for lung cancer and COPD stable period. On the basis of this, the observation group was given inhaled therapy with symbicort turbulaler.1 intake / time, 2 times /d, 1 times in the morning and evening, regular treatment for 3 months, regular follow-up during treatment. Results: There was no difference in the two lung function indexes, inflammatory factors and quality of life scores before treatment (P>0.05). After treatment, the FEV1% and FEV1/FVC indexes of the two groups were significantly improved, and the observation group was significantly higher than the control group (P<0.05). IL-6 and IL-8 indicators of two groups were significantly reduced.The observation group was significantly lower than the control group (P<0.05). During the follow-up period, the incidence of adverse reactions in the observation group was 17.95%, and the incidence of adverse reactions in the control group was 12.82%, the difference was not statistically significant (P>0.05). Conclusion: Inhaled therapy with symbicort turbulaler can significantly improve lung function and quality of life in patients with chronic obstructive pulmonary disease with stable stage of lung cancer, and is worthy of promotion. 2018 Vol. 24 (8): 1380-1383 [Abstract] ( 71 ) HTML (1 KB)  PDF (1324 KB)  ( 150 ) 1384 Clinical Application on Acute Non-normalvolemic Hemodilution in Laparoscopic Hepatectomy ZHANG Yuenong, DENG Jingdan, LUO Rong, et al DOI: 10.3969/j.issn.1006-6233.2018.08.041 Objective: To investigate the safety and effectiveness of the acute non-normalvolemic hemodilution (ANIH) method in laparoscopic hepatectomy. Method: 50 patients were selected for laparoscopic hepatectomy. According to the treatment method, it was divided into the ANIH group and the control group, with the age ranging from 21 to 77 years. The two groups were all operated with low central venous pressure under control, and the number of intraoperative blood loss and allogeneic blood transfusion cases in the two groups were compared. The postoperative hospitalization time, mean arterial pressure, heart rate and liver function before and after surgery were compared. Results: There was no significant difference in the level of CVP, HR and MAP before operation (P > 0.05) in the two groups. The level of CVP and the level of MAP after blood collection in group ANIH were lower than those in the control group (P < 0.05), and there was no significant difference between the two groups at each period of the HR level (P > 0.05). The liver function related indexes of group ANIH and control group before and after operation (AST, ALT, ALB, TBIL), there was no significant difference between the two groups before operation (P>0.05). The liver function indexes were improved after the operation, and the difference was statistically significant (P < 0.05) before and after operation (P < 0.05). The liver function index of ANIH group was improved compared with the control group. The situation was better. The bleeding volume in group ANIH was lower than that in the control group (P < 0.05), and there was no significant difference in the number of allogeneic blood samples (P>0.05). The recovery time of gastrointestinal tract in group ANIH was significantly lower than that in control group (P < 0.05), and there was no significant difference in hospitalization time between the two groups (P>0.05). Conclusion: The application of acute non-isovolemic hemodilution in laparoscopic hepatectomy is helpful to control low central venous pressure, reduce the chance of bleeding and transfusion of allogeneic blood, and is safe and reliable for patients during perioperative period. 2018 Vol. 24 (8): 1384-1387 [Abstract] ( 65 ) HTML (1 KB)  PDF (1316 KB)  ( 124 ) 1388 Therapeutic Observation and Analysis of Complication Related Factors in the treatment of Varicosis of great Saphenous Vein with EVLA and NMIS DU Jianqing, ZHAO Bo, JIANG Haijun, et al DOI: 10.3969/j.issn.1006-6233.2018.08.042 Objective: To analyze the curative effect and related factors of the treatment of varicose saphenous vein with EVLA and NMIS. Methods: A total of 218 patients with varicosities treated in our hospital from August 2016 to November 2017 were enrolled in this study. All patients were divided into EVLA group and NMIS group according to the random sequence generation method. All the patients in EVLA group were treated with endovascular laser ablation. The NMIS group was treated with new minimally invasive dissection device. The curative effect, clinical indicators and complication of the two groups were compared after different surgical treatment. Results: There was no significant difference in operative time between the two groups (P> 0.05). The mean amount of bleeding and hospital stay in NMIS group was significantly higher than that in EVLA group (P <0.05), mean hospitalization expense was significantly lower than that in EVLA group (P <0.05); VCSS and CIVIQ scores of two groups were significantly higher than before treatment (P <0.05), there was no significant difference between the two groups in the treatment of VCSS and CIVIQ score (P> 0.05); The complications of numbness, hematoma and ecchymosis were found in both NMIS group and EVLA group. The infection was independently present in the NMIS group, and the incidence of complications in the NMIS group was significantly higher than that in the EVLA group (P <0.05). Conclusion: Both EVLA and NMIS have their own advantages in clinical treatment of varicose saphenous vein, but there are still some limitations. The clinical application of EVLA and NMIS can be based on the patient's own situation to choose the surgical approach, the ultimate goal is to improve surgical treatment effect, reduce the occurrence of intraoperative and postoperative adverse events. 2018 Vol. 24 (8): 1388-1391 [Abstract] ( 80 ) HTML (1 KB)  PDF (1315 KB)  ( 119 ) 1394 Application of Self-management Nursing Intervention in Improving Self-care Level and Self-efficacy of Postoperative Patients with Lung Cancer after Chemotherapy JIAO Ying DOI: 10.3969/j.issn.1006-6233.2018.08.044 Objective: To explore the application of self-management nursing intervention in improving the level of self-care and self-efficacy of patients with lung cancer after operation. Methods: In our hospital from June 2015 to June 2017, 98 cases of lung cancer patients receivied chemotherapy after surgery, were randomly divided into control group and study group with 49 cases in each group, the control group of all lung cancer patients receiving chemotherapy after surgery were treated with routine nursing, the study group with the self management of nursing intervention based on routine nursing care, and by measuring the self-care ability scale and the quality of life scale, general self-efficacy scale and short fatigue scale to evaluate the nursing effect of two groups. Results: The self-concept, health knowledge, self-responsibility and self-efficacy of the study group were significantly higher than those of the control group (P < 0.01). According to the results of short fatigue scale, the fatigue score of the study group was significantly lower than that of the control group (P<0.001). According to the results of the quality of life measurement, the study group was significantly higher than the control group in the aspects of environmental factors, physiological factors, social factors, psychological factors and quality of life (P<0.001). Conclusion: Self-management nursing intervention is of great significance in improving the level of self-care and self-efficacy of patients with lung cancer after chemotherapy, and it can reduce the fatigue degree of postoperative patients with chemotherapy and improve their quality of life. 2018 Vol. 24 (8): 1394-1396 [Abstract] ( 68 ) HTML (1 KB)  PDF (1298 KB)  ( 142 ) 1397 Effectiveness Analysis of Yiqi Huoxue Bushen Decoction Combined with Fasudil on Cerebral Thrombosis and its Effect on Cognitive Function JIN Dong DOI: 10.3969/j.issn.1006-6233.2018.08.045 Objective: To explore the clinical effect of Yiqi Huoxue Bushen decoction combined with fasudil in the treatment of cerebral thrombosis and its influence on patients' cognitive function. Methods: 100 patients with cerebral thrombosis treated in our hospital from January 2016 to January 2017 were selected as the subjects. They were divided into study group ( n = 50 ) and control group ( n = 50 ). The control group was treated with Yiqi Huoxue Bushen decoction combined with conventional antithrombotic drugs. The study group was treated with Yiqi Huoxue Bushen decoction combined with fasudil. the clinical efficacy of the two groups was compared after treatment, and the nfd and mbi scores of the two groups were compared. The hemorheology indexes of the two groups were compared. Results: The clinical efficacy of the patients in the study group was significantly better than that of the control group (P<0.05). The NDF score of the patients in the study group was significantly lower than that of the control group and the MBI score was significantly higher than that of the control group (P<0.05). The hemorheological indexes (FIB, HBV, ESR, HCT) of the patients in the study group were significantly lower than those of the control group (P<0.05). Conclusion: Yiqi Huoxue Bushen decoction combined with Shu Di injection has good clinical effect in the treatment of cerebral thrombosis. It can obviously improve the curative effect of the clinical treatment, improve the blood flow status of the patients, improve the MBI, NFD score, improve the treatment experience of the patients, and improve the recovery of cognitive function. It is of great benefit to the treatment of cerebral blood thrombus. 2018 Vol. 24 (8): 1397-1400 [Abstract] ( 69 ) HTML (1 KB)  PDF (1319 KB)  ( 150 ) 1401 Clinical Study on Selective Denervation of Fire Needle combined with Extracorporeal Shock Wave for Knee Osteoarthritis LIU Yanwei, et al DOI: 10.3969/j.issn.1006-6233.2018.08.046 Objective: To observe the therapeutic effect of knee ostarthritis on the method of fire needles high selectivity in denervation combined with extracorporeal shock wave and to provide theoretical basis for the treatment of knee ostarthritis by integrated traditional Chinese and western medicine. Methods: Eighty patients with knee osteoarthritis were randomly divided into treatment group and control group. The treatment group was treated with fire needle denervation combined with extracorporeal shock wave therapy. The control group was treated with meroxicam tablets. WOMAC score and HSS score were evaluated before treatment, 3 weeks after treatment and 1 month after treatment, and adverse reactions were recorded. Results: The WOMAC score and HSS score of the treatment group and the control group were statistically significant after treatment (P<0.05), and the treatment group was significantly better than the control group, the two groups were statistically significant (P<0.05). Conclusion: Fire needle selective denervation combined with extracorporeal shock wave therapy is effective in improving the range of motion of the knee joint and relieving pain without serious complications, which is worthy of clinical application. 2018 Vol. 24 (8): 1401-1403 [Abstract] ( 72 ) HTML (1 KB)  PDF (1300 KB)  ( 230 ) 1404 Clinical Effectiveness Analysis of Warfarin Anticoagulation Therapy in Patients with non Valvular Atrial Fibrillation Guided by Clinical Pharmacists WANG Jinfeng, XING Laili, WEI Xiaoli, et al DOI: 10.3969/j.issn.1006-6233.2018.08.047 Objective: To analyze the efficacy of warfarin anticoagulation therapy in patients with non valvular atrial fibrillation under the guidance of clinical pharmacists. Methods: 91 patients with non-valvular atrial fibrillation who received therapy from January 2014 to June 2017 in our hospital, according to different treatment methods. All the patients were divided into 47 control groups and 44 research groups. The control group was treated with traditional warfarin, and the research group was given warfarin under the guidance of clinical pharmacist. then treatment compliance, international standardized ratio (INR), endothelial function, fibrinolytic index, and adverse reactions between two group was compared. Results: After treatment, the therapeutic compliance in the research group was better than that of the control group, with statistically significant difference (P<0.05). the INR compliance rate in research group was higher than the control group (P<0.05). Before treatment,the endothelin 1 (ET-1), circulating endothelial cells (CEC) in two group was no difference (P>0.05), after treatment, the above indicators in research group was lower than the control group, with statistically significant difference (P<0.05). plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (t-PA) and D-dimer (D-D) in research group were lower than the control group (P<0.05). Complication rate in research group was lower than that in the control group (P<0.05). Conclusion: Non-valvular AF patients with clinical pharmacist guidance warfarin anticoagulant therapy can change the patient's cognitive and behavioral status, improve their treatment compliance and INR compliance rate, reduce the risk of warfarin anticoagulation. 2018 Vol. 24 (8): 1404-1408 [Abstract] ( 48 ) HTML (1 KB)  PDF (4494 KB)  ( 131 )

Copyright © Editorial Board of HeBei Med Supported by:Beijing Magtech