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2019 Vol. 25, No. 2 Published: 2019-02-28 177 Expressions and Clinical Significances of MiR-144-3p L and SGK3 in Oral Squamous Cell Carcinoma YAN Mengxiong, HUA Wei, GAO Guilin DOI: 10.3969/j.issn.1006-6233.2019.02.001 Objective: To investigate the expressions of miR-144-3p and serum/glucocorticoid regulated protein kinase 3 (SGK3) in the oral squamous cell carcinoma (OSCC) tissues, and to analyze the relationships between the them with the clinicopathological feature and prognosis. Methods: 78 cases of OSCC tissue specimens were selected as case group, and normal oral mucosa epithelium specimens were taken as control group, real time quantitative PCR (RT-PCR) was used to detect the relative expressions of miR-144-3p and SGK3 in tissues, Western blot and immunohistochemistry were used to detect the SGK3 protein expression in tissues, the relationships between the them with clinicopathological features and prognosis were analyzed. The working characteristic curve (ROC) of the subjects was made, evaluated the diagnostic efficiencies of miR-144-3p and SGK3 for OSCC; all patients were followed up for 30 months, the survival rate of patients was statistically analyzed, survival was analyzed by Kaplan-Meier, survival differences between the two groups were detected by Log-Rank. Pearson correlation analysis was used to analyze the correlation between miR-144-3p and SGK3. Results: Compared with the control group, the expression of miR-144-3p mRNA in OSCC group was increased, SGK3 mRNA, protein and protein positive expression were all decreased (P<0.05), miR-144-3p expression and SGK3 positive expression were not related to sex, age, smoking status and depth of tumor invasion (P>0.05), was related to TNM stage, tumor differentiation and lymph node metastasis (P<0.05). The ROC curve showed that the AUC of miR-144-3p in the prediction of OSCC was 0.767, the sensitivity was 71.79%, and the specificity was 63.96%. The AUC of SGK3 in the prediction of OSCC was 0.683, the sensitivity was 66.67%, and the specificity was 75.64%. Followed up for 30 months, 27 patients died, the survival rate was 65.38%. The mortality rates of miR-144-3p high expression group (44.68%) and SGK3 negative group (48.78%) were significantly higher than those of miR-144-3p low expression group (19.35%) and SGK3 positive group (18.92%), Kaplan-Meier survival curve showed that the overall survival rate of the two groups was significantly different (P<0.05). There was a significant negative correlation between miR-144-3p and SGK3 expression (r=-0.417, P<0.05). Conclusion: The expression of miR-144-3p in OSCC tissues is up-regulated, and the expression of SGK3 is down-regulate, it is related to the stage of tumor, the degree of differentiation, and lymph node metastasis, it may be a biological indicator of the diagnosis and prognosis of OSCC. 2019 Vol. 25 (2): 177-181 [Abstract] ( 138 ) HTML (1 KB)  PDF (1870 KB)  ( 173 ) 182 Diagnostic Value of Combined Detection of Serum β-HCG hs-CRP and IL-6 for Premature Rupture of Membranes with Intrauterine Infection LI Jie DOI: 10.3969/j.issn.1006-6233.2019.02.002 Objective: To analyze the diagnostic value of combined detection of serum human chorionic gonadotropin (β-HCG), high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) for premature rupture of membranes with intrauterine infection. Methods: 82 pregnant women with premature rupture of membranes diagnosed in the hospital from June 2016 to June 2017 were divided into the infected group and the control group according to the presence of intrauterine infection. The fasting venous blood samples of both groups were collected to detect levels of serum β-HCG, hs-CRP and IL-6. The critical values of the three serum indicators were determined according to the receiver operating characteristic (ROC) curve. Prediction and diagnosed of intrauterine infection were performed. Results: Of the 82 pregnant women with premature rupture of membranes, 38 cases (46.34%) had intrauterine infection, including 15 cases of mild infection, 15 cases of moderate infection and 8 cases of severe infection. Compared with the control group, levels of serum β-HCG, hs-CRP and IL-6 were significantly higher in the infected group (P<0.05). Levels of serum β-HCG, hs-CRP and IL-6 showed pregnant women with mild intrauterine infection < moderate infection < sever infection (P<0.05). According to the ROC curves, the diagnostic thresholds of serum β-HCG, hs-CRP and IL-6 were 3.32 ng/mL, 4.09 mg/L and 14.15 mg/L, respectively. The sensitivity, specificity and accuracy of combined detection of the three serum indicators in diagnosis of intrauterine infection were 92.11%, 90.91%and 91.46%, respectively, higher than those any indicator alone (P<0.05). Conclusion: The levels of serum β-HCG, hs-CRP and IL-6 are significantly higher in pregnant women with premature rupture of membranes and intrauterine infection than in uninfected pregnant women, and they are closely related to the severity of infection. Combined detection of the three serum indicators can improve the diagnostic efficiency for premature rupture of membranes with intrauterine infection. 2019 Vol. 25 (2): 182-185 [Abstract] ( 124 ) HTML (1 KB)  PDF (1391 KB)  ( 244 ) 186 Evaluation of Liver Fibrosis by Real-time Two-dimensional Quantitative Shear Wave Elastography (E-Imaging) BIAN Jinhua, ZHOU Qi, JIANG Yu, et al DOI: 10.3969/j.issn.1006-6233.2019.02.003 Objective: To explore the value of real-time two-dimensional quantitative shear wave elastography (E-imaging) in evaluating the degree of liver fibrosis. Method: A total of 153 patients with clinically confirmed hepatic fibrosis were enrolled. All patients were examined by E-imaging. According to the pathological results of liver puncture, all patients were divided into four groups: hepatic fibrosis stage 1 group (S1 group), hepatic fibrosis stage 2 group (S2 group), hepatic fibrosis stage 3 group (S3 group) and hepatic fibrosis stage 4 group (S4 group), and 80 normal persons in the same period were selected as control group. The difference of Young's modulus of elasticity between groups was compared. Results: The case group was compared with the control group. The control group was significantly lower than that of hepatic fibrosis group (P<0.05). The Young's modulus of elasticity in case group was significantly higher than that in control group< S1 group< S2 group< S3 group< S4 group (P<0.05). Conclusion: Real-time two-dimensional quantitative shear wave elastography (E-imaging) can provide objective criteria for evaluating the grading of liver fibrosis. 2019 Vol. 25 (2): 186-188 [Abstract] ( 100 ) HTML (1 KB)  PDF (2846 KB)  ( 294 ) 189 Evaluation on Therapeutic Efficacy of Chuankezhi by Different Administration Pathways Combined with Salmeterol Rinafoate and Fluticasone Propionate Powder for Inhalation on Acute Exacerbation of Moderate-Severe COPD LI Meng, HUANG Minqiang, HE Guanghui, et al DOI: 10.3969/j.issn.1006-6233.2019.02.004 Objective: To investigate therapeutic efficacy evaluation of chuankezhi injection by different administration pathways combined with salmeterol xinafoate and fluticasone propionate powder for inhalation in the treatment of acute exacerbation of moderate-severe chronic obstructive pulmonary disease (COPD). Methods: 90 cases of moderate-severe COPD in acute exacerbation treated in our hospital from January 2016 to April 2018 were selected and equally divided into two groups. The control group received the salmeterol xinafoate and fluticasone propionate powder for inhalation, while the treatment group received the chuankezhi by different administration combined with salmeterol xinafoate and fluticasone propionate powder for inhalation. Then the clinical efficacy, adverse reactions, pulmonary function indicators, blood gas parameters, mMRC scores, and CAT scores of the two groups were compared. Results: The total clinical efficacy of the treatment group was higher than that of the control group, and the difference was statistically significant (88.89% vs 71.11%, P<0.05); The FEV1, FEV1/FVC, PEF and 6min walking distance of the two groups were increased after treatment, and were higher in the treatment group than those in the control group (P<0.05); The PaCO2 of the two groups were decreased, while the PaO2 and SaO2 were increased after treatment (P<0.05); The treatment group had lower level of PaCO2 as well as higher levels of PaO2 and SaO2 than those of the control group (P<0.05); The scores of mMRC and CAT of the two groups were decreased (P<0.05), and were lower in the treatment group than in the control group (P<0.05); The incidence rate of the adverse reactions of the two groups had no difference (8.88% vs 6.66%, P>0.05). Conclusion: Chuankezhi injection by different administration pathways combined with salmeterol xinafoate and fluticasone propionate powder for inhalation is an effective way to ameliorate the pulmonary function, blood indexes and quality of life for acute exacerbation of moderate-severe COPD. 2019 Vol. 25 (2): 189-192 [Abstract] ( 130 ) HTML (1 KB)  PDF (1261 KB)  ( 299 ) 193 Value of Multiple b-value DWI combined with DCE-MRI in the Differential Diagnosis of Prostate Cancer and Benign Prostatic Hyperplasia LI Peng, et al DOI: 10.3969/j.issn.1006-6233.2019.02.005 Objective: To explore the value of multiple dispersion sensitivity coefficient (b-value) diffusion-weighted imaging (DWI) combined with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in the differential diagnosis of prostate cancer (PCa) and benign prostatic hyperplasia (BPH). Methods: The clinical data of 82 patients suspected as PCa (observation group) from January 2014 to March 2018 were retrospectively analyzed. Another 30 healthy examiners at the same time period were selected as control group. All patients and control group were given DWI and DCE-MRI. The DWI signal intensity value (SI) and apparent diffusion coefficient value (ADC) were evaluated at different b values, and the values of single DWI, single DCE-MRI and combined detection were compared in the differential diagnosis of prostate diseases. Results: The accuracy was the highest by DWI combined with DCE-MRI, and the accuracy was the lowest by DCE-MRI (P<0.05). The sensitivity was the highest by combined detection, and the sensitivity was the lowest by DCE-MRI (P>0.05). The specificity was the highest by combined detection, and was the lowest by DCE-MRI (P>0.05). There was no statistically significant difference in the specificity of PCa by multiple b-value DWI and DCE-MRI (P>0.05). The accuracy and sensitivity of PCa by multiple b-value DWI were higher than those by DCE-MRI (P>0.05). When b=800, 1000s/mm2, the SI of PCa was higher than that of BPH and normal prostate tissue while the ADC of PCa was lower than that of BPH and normal prostate tissue (P<0.05). There were no significant differences between BPH and normal prostate tissue in the SI and ADC (P>0.05). When b=800s/mm2, the PC and ADC of PCa, BPH and normal prostate tissue were higher than those when 1000s/mm2 (P<0.05). Conclusions: Multiple b-value DWI combined with DCE-MRI has good diagnostic efficiency in the differential diagnosis of PCa and BPH, and it is beneficial to improve the accuracy of clinical diagnosis. 2019 Vol. 25 (2): 193-196 [Abstract] ( 102 ) HTML (1 KB)  PDF (1262 KB)  ( 208 ) 197 Diagnosis Value of Serum β-HCG ALP Combined Transabdominal Color Doppler Ultrasound for Early Ectopic Pregnancy LIU Aihua, WANG Dong, YAO Shuiping, et al DOI: 10.3969/j.issn.1006-6233.2019.02.006 Objective: To investigate the value of serum β-human chorionic gonadotropin (β-HCG), alkaline phosphatase (ALP) and transabdominal color doppler ultrasound in the diagnosis of ectopic pregnancy. Methods: A total of 47 patients with ectopic pregnancy in our hospital from March 2017 to March 2018 were selected. 51 pregnant women with normal pregnancy were selected as controls. Retrospective analysis of serum β-HCG, ALP level and the gestational sac, endometrial thickness and other indicators detected by transabdominal color Doppler ultrasound and compared. Results: The incidence of abdominal pain, vaginal bleeding, abdominal tenderness, uterine enlargement, attachment tenderness and cervical lift were significantly higher in ectopic pregnancy group than that in normal pregnancy group (P<0.05). The level of serum β-HCG in ectopic pregnancy group was significantly lower than that in normal pregnancy group [(1554.12±279.21) vs (3267.98±610.21) mIU/mL, P<0.05]. The level of serum ALP in ectopic pregnancy group was significantly lower than those in the normal pregnancy group [(29.45±5.23) vs (42.37±9.72) mIU/mL, P<0.05]. Spearman test showed that serum β-HCG level was positively correlated with ALP level in ectopic pregnancy group (r = 0.630, P<0.05). The incidence of endometrial thickness ≤ 10mm, attachment area with mass, intrauterine no gestational sac, fetal heart rate in ectopic pregnancy group was significantly higher than that of the normal pregnancy group (P<0.05). The of serum β-HCG and ALP in combination with abdominal color Doppler ultrasonography were 96.08%, which were higher than those used one of them (P<0.05). Conclusion: Combined serum β-HCG, ALP with abdominal color Doppler ultrasonography can significantly improve the diagnosis rate of early ectopic pregnancy, which is valuable to promote. 2019 Vol. 25 (2): 197-200 [Abstract] ( 76 ) HTML (1 KB)  PDF (1372 KB)  ( 318 ) 201 The Relationships Between Serum 25-Hydroxyvitamin D and Hcy with Cognitive Dysfunction in Patients with Parkinson's Disease LIU Guian, SHI Jing DOI: 10.3969/j.issn.1006-6233.2019.02.007 Objective: To explore the relationships between serum 25-hydroxyvitamin D and homocysteine (Hcy) with cognitive dysfunction in patients with Parkinson's disease. Methods: 132 cases of Parkinson's disease in our hospital from February 2014 to March 2018 were selected as observation group, and 75 cases of healthy physical examination were selected as control group, serum 25-hydroxyvitamin D and Hcy levels were detected, cognitive function was assessed by the Montreal cognitive assessment scale (MoCA), the correlations between serum 25-hydroxyvitamin D and Hcy levels with cognitive dysfunction were analyzed by Pearson correlation analysis, the risk factors of cognitive dysfunction were analyzed by unconditional logistic regression analysis. Results: The level of serum 25-hydroxyvitamin D in the observation group was significantly lower than that in the control group, while the level of Hcy was significantly higher than that in the control group (P<0.05); the executive ability, naming, attention, language, abstract thinking, delayed memory, directional ability and total score of the observation group were significantly lower than those of the control group (P<0.05); serum 25-hydroxyvitamin D was positively correlated with MoCA score, and Hcy level was negatively correlated with MoCA score (all P<0.05); the results of Logistic regression analysis showed that age, years of education, total cholesterol, triglyceride, diabetes, hypertension, 25-hydroxyvitamin D and Hcy were risk factors for cognitive impairment (P<0.05). Conclusion: The levels of serum 25-hydroxyvitamin D is significantly decreased in patients with Parkinson's disease, while Hcy is increased significantly, both of them are related to cognitive dysfunction,detection of 25-hydroxyvitamin D and Hcy levels is of great importance for early diagnosis and treatment of Parkinson's disease. 2019 Vol. 25 (2): 201-204 [Abstract] ( 134 ) HTML (1 KB)  PDF (1339 KB)  ( 293 ) 205 Clinical Value of Combined Detection of Thyrotropin and Thyroglobulin in the Diagnosis of Benign and Malignant Thyroid Nodules PENG Huali, LI Linwu, YONG Jin, et al DOI: 10.3969/j.issn.1006-6233.2019.02.008 Objective: To analyze the clinical value of combined detection of thyroid stimulating hormone (TSH) and thyroglobulin (Tg) in the diagnosis of benign and malignant thyroid nodules. Methods: The clinical data of 196 patients with thyroid nodules (TN) in our hospital were retrospectively analyzed. According to the results of pathological diagnosis, the patients were divided into malignant group (n=57) and benign group (n=139). Serum TSH and Tg levels were compared between the two groups. Logistic regression analysis and receiver operating curve (ROC curve) were used to evaluate the clinical value of TSH, Tg and the combined examination in the diagnosis of benign and malignant thyroid nodules. Results: Serum TSH and Tg levels in malignant group were higher than those in benign group (P<0.05). The ROC curve of serum TSH level showed AUC was 0.739 (P<0.05), and the critical value was 2.45mIU/L, and the diagnostic sensitivity and specificity were 0.754 and 0.770 respectively. The ROC curve of serum Tg level showed AUC was 0.728 (P<0.05), and the critical value was 72.66ng/mL, and the diagnostic sensitivity and specificity were 0.421 and 0.778 respectively. The AUC of TSH combined with Tg was 0.815, and the sensitivity and specificity were 0.749 and 0.821 respectively, and the above indexes were significantly higher than those of single TSH or Tg (P<0.05). Conclusions: The combined detection of TSH and Tg in the diagnosis of benign and malignant thyroid nodules has good accuracy, sensitivity and specificity, and has certain clinical value. 2019 Vol. 25 (2): 205-207 [Abstract] ( 87 ) HTML (1 KB)  PDF (1378 KB)  ( 264 ) 208 Effects of Early Intracranial Aneurysm Clipping on Serum Inflammatory Cytokines Levels and Complication Rate in Patients with Intracranial Aneurysms WANG Xu, CHEN Feng, ZHOU Daquan, et al DOI: 10.3969/j.issn.1006-6233.2019.02.009 Objective: To investigate the application value of early intracranial aneurysm clipping in patients with intracranial aneurysms. Methods: 72 patients with intracranial aneurysms from February 2015 to March 2017 in Xiangyang central hospital were randomly divided into groups, 36 cases in each groups. The control group was treated with intravascular embolization, and the study group was treated with early intracranial aneurysm. Neurological function score (NIHSS) and daily life ability score (BI), serum inflammatory factor TNF-α, IL-1 and IL-6 levels preoperative and postoperative 1 month, the incidence of complications1 month after operation and the prognosis12 months after operation were statistically compared between the two groups. Results: The BI scores of the two groups after operation were higher than those before operation, while the NIHSS scores were lower than those before operation; the score of BI in the study group was higher than that in the control group, and the NIHSS score was lower than that in the control group (P<0.05); The serum TNF-α, IL-1 and IL-6 levels in the two groups after operation were lower than those before the operation, and the study group was lower than the control group, the difference was statistically significant (P<0.05); The incidence of complication in the study group 11.12% (4/36) was lower than that of the control group 33.35% (12/36), the difference was statistically significant (P<0.05); The good recovery rate of the study group 61.11% (22/36) was higher than that of the control group (30.56%, 11/36), the difference was statistically significant (P<0.05). Conclusion: Early clipping of intracranial aneurysms is effective in the treatment of intracranial aneurysms. It can effectively reduce the level of serum inflammatory factors, improve the neurological function and daily living ability of patients, and improve the prognostic effect. It is safe and worth popularizing. 2019 Vol. 25 (2): 208-210 [Abstract] ( 98 ) HTML (1 KB)  PDF (1241 KB)  ( 234 ) 211 Relationship between Neurobehavioral Behavior of Simple Obesity and Serum IGF-1 and GH levels in Preschool Children HUANG Chun, TAN Chi, WANG Xin, et al DOI: 10.3969/j.issn.1006-6233.2019.02.010 Objective: To study the incidence of neural behavioral problems and the changes of serum insulin growth factor-1 (IGF-1) and growth hormone (GH) levels of preschool children with simple obesity, and to explore the correlations between neural behavioral of children with simple obesity with the serum IGF-1 and GH. Methods: 120 preschool children aged 4-6 years in a certain urban area of Nanning, 60 children with body weight exceeding 20% of standard weight were selected as obese group, and 60 children with normal weight were used as normal group. The Achenbach Child Behavior Checklist (CBCL) was used to assess the psychological and behavioral abilities of the children, detection of serum IGF-1 and GH levels in children by enzyme-linked immunosorbent assay (ELISA), the relationships between CBCL score with serum IGF-1 and GH were analyzed. Results: The incidence rate of abnormal neural behavioral problems in obese group was significantly higher than that in the normal group (χ2=10.159, P=0.001), the incidence rate of neural behavioral abnormalities in children with severe obesity was significantly higher than that in children with mild to moderate obesity (χ2=4.516, P=0.034); the CBCL total score of boys in obesity group was significantly higher than that of boys in normal group (P<0.05), the CBCL total score of girls was significantly higher than that of girls in the normal group (P<0.05); the serum IGF-1 levels in obese children were significantly higher than those in the normal group (P<0.05), serum GH levels were significantly lower than those in normal group (P<0.05), the heavier the level of obesity, the higher the level of serum IGF-1, the lower the level of GH; the CBCL score is significantly positively correlated with the serum IGF-1 in obese group (r=0.622, P=0.000), was negatively correlated with serum GH level (r=-0.489, P=0.012). Conclusion: The incidence rate of neural behavioral abnormality in preschool children with simple obesity is increased, and is related to the severity of obesity, the increase of serum IGF-1 level and decrease of GH level. 2019 Vol. 25 (2): 211-214 [Abstract] ( 128 ) HTML (1 KB)  PDF (1296 KB)  ( 278 ) 215 Clinical Effect of Neuropathic factor in the treatment of Cerebral Infarction and its effect on plasma D-D, TXB2 and BNP YIN Xingzhi DOI: 10.3969/j.issn.1006-6233.2019.02.011 Objective: To study the efficacy of rat neurotrophic factor in the treatment of cerebral infarction and its effects on plasma D-D, TXB2 and BNP. Methods: From April 2015 to March 2016, 120 patients with cerebral infarction were selected in our hospital, those patients were randomly divided into control group (60 cases) and experimental group (60 cases) according to simple random grouping. The control group was treated with conventional drugs. The experimental group were given nerve growth factor to complete the treatment on the basis of control group. The clinical efficacy, daily living ability (ADL) and neurological score, plasma D-D, TXB2 and BNP levels were compared between the two groups. Results: After treatment, the total effective rate was 83.33% in the experimental group was significantly higher than that in the control group 70.00% (P<0.05). The scores of ADL in the experimental group were significantly higher than those in the control group [(64.60±5.13)points VS(54.51±5.33)points] (P<0.05), NIHSS score was significantly lower than that of the control group [(9.49±1.03)points VS (15.04±1.17) points] (P<0.05). The levels of DD, TXB2 and BNP in the test group were significantly lower than those in the control group [(0.47±0.04)mg/L,(46.14±3.88)ng/L,(10.93±1.29)pg/ml VS(1.23±0.15)mg/L, (68.80±6.19)ng/L,(18.56±2.07)pg/ml](P<0.05). Conclusion: The treatment of neurological growth factor in patients with cerebral infarction can effectively reduce the levels of plasma D-D, TXB2 and BNP, improve the clinical symptoms of patients, the clinical efficacy is good and the safety is high. 2019 Vol. 25 (2): 215-218 [Abstract] ( 100 ) HTML (1 KB)  PDF (1259 KB)  ( 259 ) 219 Effects of Neoadjuvant Chemotherapy with Paclitaxel and Cisplatin on Lymph Node Metastasis and Long Term of Prognosis in Patients with Advanced Cervical Cancer XIANG Anling, ZHUANG Ruichun, PENG Ling DOI: 10.3969/j.issn.1006-6233.2019.02.012 Objective: To analyze the effects of neoadjuvant chemotherapy with paclitaxel and cisplatin on lymph node metastasis and long term of prognosis in patients with advanced cervical cancer. Methods: 78 cases of advanced cervical cancer who underwent radical hysterectomy and pelvic lymph node dissection were selected in our hospital and were randomly divided into the control group and study group, with 39 cases in each group. The control group underwent the treatment program of cisplatin, leucovorin calcium, fluorouracil glucoside and doxorubicin before surgery, and the study group were treated with neoadjuvant chemotherapy with paclitaxel and cisplatin before surgery. The rate of lymph node metastasis and long term of prognosis were compared between the two groups after treatment. Results:The total efficiency of the study group was higher than that of the control group (P<0.05); the rate of lymph node metastasis, vascular invasion, parametrial involvement in the study group were lower than those in the control group (P<0.05); the incidence rate of adverse reactions of the two groups showed no different significance (P>0.05); the survival rate of 3 years and median survival time in the study group were higher than those in the control group (P<0.05). Conclusion: Neoadjuvant chemotherapy of paclitaxel combined with cisplatin can significantly reduce the rate of lymph node metastasis in patients with advanced cervical cancer before operation and reduce the range of lesions, which can improve the clinical effects and help to improve the long-term of survival rate. 2019 Vol. 25 (2): 219-222 [Abstract] ( 102 ) HTML (1 KB)  PDF (1270 KB)  ( 209 ) 223 Effect of Nutritional Risk Screening on Clinical Outcomes of Orthopaedic Inpatients ZHANG Qing, LIU Yongrui, HE Yixin, et al DOI: 10.3969/j.issn.1006-6233.2019.02.013 Objective: To investigate the incidence of nutritional risk and the status of nutritional support among inpatients in department of orthopedics. Methods: Nutritional risk screening was performed according to the NRS2002 scoring criteria. Nutritional support was divided into intervention group and non intervention group according to whether or not to accept intervention. The albumin and total protein, incidence of infection related. Albumin, total protein, incidence of infection-related complications and hospitalization time were compared between the two groups. Results: Among the 158 patients in Department of orthopedics, 52 (32.9%) had nutritional risk and 33 (20.9%) did not have nutritional support. Among the patients who had nutritional risk, there were 18 (11.4%) cases of nutritional support. Among the 52 hospitalized patients with nutritional risk in the Department of orthopedics, there was no significant difference in the total albumin and total protein between the nutrition support intervention group and the untreated group (P>0.05), and the difference of the discharged albumin intervention group was significantly higher than that of the undone group (P<0.05). The incidence of infection and complications in the nutritional support group was less than that in the non nutritional support group (P<0.05), and the time of hospitalization was also shorter than that in the non nutritional support group (t=2.86, P<0.05). Conclusion: Positive nutritional risk screening should be carried out for patients in the Department of orthopedics. Nutritional support for patients with nutritional risk can effectively improve their nutritional status and shorten the time of hospitalization. 2019 Vol. 25 (2): 223-225 [Abstract] ( 123 ) HTML (1 KB)  PDF (1227 KB)  ( 222 ) 226 Effects of Atorvastatin and Folic Acid Tablets on Homocysteine and Carotid Atherosclerosis in Patients with Type H Hypertension ZHANG Yejin, WEI Xiaona DOI: 10.3969/j.issn.1006-6233.2019.02.014 Objective: To investigate the effects of atorvastatin and folic acid tablets on homocysteine and carotid atherosclerosis in patients with type H hypertension. Methods: A total of 90 patients with H-type hypertension in the internal medicine clinic of Jieyang Traditional Chinese Medicine Hospital were enrolled. The patients were divided into atorvastatin group, folic acid group and control group by random grouping method. The changes of blood pressure, homocysteine (Hcy), blood lipids, carotid intima-media thickness (IMT), and sputum pulse wave velocity (baPWV) levels were analyzed before and after treatment. And the adverse reactions that occurred were recorded during the treatment. Results: The systolic and diastolic blood pressures of the three groups were significantly lower than those before treatment (P<0.05), and the blood pressure reduction in the atorvastatin group and the folic acid group was significantly better than that in the control group (P<0.05). There was no significant difference in blood pressure (P>0.05). There were no significant differences in Hcy, cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein, IMT, and baPWV between the folic acid group and the folic acid group (P>0.05). The level of Hcy, cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein, IMT, and baPWV in the atorvastatin group and the folic acid group were significantly improved after treatment (P<0.05), and the atorvastatin group and the folic acid group after treatment. The improvement of each index was significantly better than that of the control group (P<0.05), but there was no significant difference between the two groups (P>0.05). During the treatment, the incidence of adverse reactions in the folic acid group was significantly higher than that in the control group and the atorvastatin group (P<0.05). There was no significant difference in the incidence of adverse reactions between the control group and the atorvastatin group (P>0.05). Conclusion: Adding atorvastatin or folic acid tablets on the basis of conventional antihypertensive therapy can reduce the level of Hcy and the degree of carotid atherosclerosis in patients with H-type hypertension, but atorvastatin is safer and can avoid the shortcomings of folic acid tablets. 2019 Vol. 25 (2): 226-228 [Abstract] ( 133 ) HTML (1 KB)  PDF (1247 KB)  ( 326 ) 229 Changes of Related Factors of Gastrointestinal Motility Disorders in Rabbit Models of Severe Acute Pancreatitis WANG Gang, HAN Junling, WANG Fang, et al DOI: 10.3969/j.issn.1006-6233.2019.02.015 Objective: To study the related factors of gastrointestinal motility disorder in rabbits with severe acute pancreatitis. Methods: 30 New Zealand SPFrabbits were randomly divided into control group and experimental group, 15 rabbits in each group. The rabbits in the experimental group were established by injection of sodium taurocholatethrough pancreatic duct, and the rabbits in the control group were operated through the experimental group, but injected with equal volume distilled water.After 24h, the general condition of the rabbit's abdominal cavity was observed, the gastrointestinal transmission index (TI) was calculated, and the serum levels of GAS, MTL, SP, VIP, CCK, TNF- a, IL-1 and IL-6 were detected. The pathological sections of the pancreas were made, under the microscope, and the pathological score was observed. Results:In the experimental group, a large number of turbidity ascites, many saponification spots, large hemorrhage and necrosis of the pancreas, obvious hyperemia and edema of the gastrointestinal tract accompanied by partial necrosis were found in the abdominal cavity. The widening of the interleaf space of the pancreas tissue, the edema of the cells, the necrosis of some acinar cells and a large number of inflammatory cells infiltrated in the experimental group.The TI in the experimental group was lower than the control group, and PSP was significantly higher(P<0.05); The concentrations of GAS, SP and VIP in the experimental group were higher, and the concentration of MTL、CCK was lower(P<0.05). The concentrations of TNF-α, IL-1 and IL-6 in the experimental group were higher(P<0.05).Conclusion: SAP white rabbits have gastrointestinal motility disorders, which are closely related to the abnormal expression of gastrointestinal hormones and inflammatory factors. 2019 Vol. 25 (2): 229-232 [Abstract] ( 144 ) HTML (1 KB)  PDF (1464 KB)  ( 326 ) 233 Quantitative Analysis of Ultrasound Elastography and Clinical Staging of Prostate Cancer LU Congqing DOI: 10.3969/j.issn.1006-6233.2019.02.016 Objective: To quantitatively analyze the parameters of ultrasound elastography (UE) of prostate cancer (PCa) and explore its application value in clinical staging of PCa. Methods: 84 cases of patients with PCa in our hospital from December 2016 to May 2018 were given transrectal real time elastography (TRTE) and given the quantitative analysis of elasticity scoring, elastic area ratio (AR), elastic strain rate ratio (SR) and elastography strain index (SI). And the relationship between each parameter and pathological grade and clinical staging of PCa was studied. Results: Among 168 patients with PCa, 61 cases were highly differentiated (36.31%), and 73 cases were moderately differentiated (43.45%) and 34 cases were poorly differentiated (20.24%), and the clinical staging showed 12 cases (7.14%) in T1 stage, 46 cases (27.38 %) in T2 stage, 83 cases (49.40%) in T3 stage and 27 cases (16.07%) in T4 stage, and there were statistically significant differences in the TRTE hardness scores in patients with different pathological grades and clinical stages (P<0.05). With the increase of PCa differentiation degree, the SR and ASI were significantly increased (P<0.05), and the difference was statistically significant in the groups (P<0.05). The AR, SR and ASI at T1~T4 of PCa patients were significantly increased (P<0.05), and the SR and ASI at T2 stage were higher than those at T1 stage, and there were statistically significant differences in the AR, SR and ASI at T2~T4 (P<0.05). After Spearman correlation coefficient analysis, TRTE elasticity score, SR and ASI were significantly positively correlated with PCa pathological grade (P<0.05), and elasticity score, AR, SR and ASI were positively correlated with PCa clinical staging (P<0.05). Conclusion: Quantitative analysis results of UE image elasticity score, AR, SR and AI have important guiding significance for PCa clinical staging and treatment. 2019 Vol. 25 (2): 233-237 [Abstract] ( 127 ) HTML (1 KB)  PDF (1275 KB)  ( 280 ) 238 The Clinical Efficacy of Ozone Autologous Blood Transfusion in the Treatment of Post-herpes Zoster Neuralgia and its Effect on Serum IL-6 and TNF- vaccine LIN Tao, DAI Yuee DOI: 10.3969/j.issn.1006-6233.2019.02.017 Objective: To observe the clinical effect of ozone autologous blood transfusion on post-herpes zoster neuralgia and its effect on serum IL-6 and TNF-α. Methods: Retrospective analysis was performed on 90 cases of post-herpetic neuralgia treated in our hospital,which were divided into control group and study group according to the treatment method. The control group was treated with prebahrain treatment and the study group was treated with prebahrain combined with ozone autologous blood transfusion. Changes in treatment efficiency, pain score, serum IL-6, TNF-α, were compared between the two groups. Results: The effective rate of treatment in the study group was 81.39%, which was significantly superior to 72.09% in the control group. Changes in VAS score, serum IL-6 and TNF-α level in the two groups after treatment were statistically significant compared with those before treatment, and VAS score, serum IL-6 and TNF-α were significantly lower in the study group than in the control group (P<0.05). Conclusion: Ozone autologous blood transfusion combined with drug therapy is effective in treating neuralgia after herpes zoster. 2019 Vol. 25 (2): 238-240 [Abstract] ( 86 ) HTML (1 KB)  PDF (1221 KB)  ( 254 ) 241 Effects of PFNA, Proximal Locking Plate and Artificial Femoral Head Replacement on Perioperative Indexes, Hip Function Recovery and Lower Limb Venous Thrombosis in Elderly Osteoporotic Patients with Femoral Intertrochanteric Fractures HUANG Shaodong, WEI Wei, LU Xianwei, et al DOI: 10.3969/j.issn.1006-6233.2019.02.018 Objective: To investigate the effects of proximal femoral nail anti-rotation (PFNA), proximal femoral locking compress plate (PF-LCP) and artificial femoral head replacement on perioperative indexes, hip function recovery and lower limb venous thrombosis in Elderly osteoporotic patients with femoral intertrochanteric fractures. Methods: 95 Elderly osteoporotic patients with femoral intertrochanteric fractures were divided into PFNA group, PF-LCP group and artificial femoral head replacement group according to different surgical procedures. The perioperative indexes were compared among groups. The incidence of postoperative complications was statistically analyzed, and D-dimer levels were measured. The patients were followed up, and hip function was evaluated at the last follow-up. Results: The surgical time, intraoperative blood loss and postoperative drainage volume of PFNA group were significantly shorter/less than those of PF-LCP group or the artificial femoral head replacement group (P<0.05). The weight-bearing time and hospital stay of the artificial femoral head replacement group was significantly shorter than that of PFNA group or PF-LCP group (P<0.05). The D-dimer levels in PF-LCP group and the artificial femoral head replacement group at 7 days after surgery were significantly higher than those in PFNA group (P<0.05). All patients were followed up, and the follow-up time was 17 to 22 months. The Harris grade of hip function in PFNA group or the artificial femoral head replacement group was significantly better than that in PF-LCP group (P<0.05). Conclusion: Both PFNA and artificial femoral head replacement can effectively improve the hip function in patients with femoral intertrochanteric fractures. The duration of PFNA is short, blood loss is little and the risk of postoperative deep venous thrombosis is low. The time in bed of patients treated by artificial femoral head replacement is short and the patient can recover quickly. 2019 Vol. 25 (2): 241-244 [Abstract] ( 85 ) HTML (1 KB)  PDF (1259 KB)  ( 277 ) 245 Expression and Clinical Meaning of Serum Endocan and Vaspin Levels in Patients with Unstable Angina Combined with Hypertension LIU Qiumei, JIN Fengbiao, ZHANG Ying, et al DOI: 10.3969/j.issn.1006-6233.2019.02.019 Objective: To investigate the expression and clinical meaning of visceral adipose tissue-derived serine protease inhibitor(Vaspin) and endothelial cell specific molecule-1(Endocan) in patients with unstable angina combined with hypertension. Methods: Our research included in 4 groups:43 patients with hypertension for HD group,61 patients with unstable angina for UA group,90 patients with unstable angina combined with hypertension for UA with HD group,35 healthy peaple for control group,All patients were diagnosed and treated in our hospital from 2017-02 to 2018-02.Vaspin and Endocan were detected by ELISA. Results: Compared with control group,Vaspin and Endocan level in HD,UA and UA with HD groups were statistically significant difference(P<0.05),and Vaspin level gradually declined while Endocan increased.Pearson correlation analysis showed that the level of Vaspin was negatively correlated with the number of coronary lesions and the Gensini score(P<0.05), while Endocan positively correlated with the number of coronary lesions and the Gensini score(P<0.05),Vaspin and Endocan were negatively correlated(r=-0.715,P<0.05).ROC curve analysis showed that the area under curve of UA with HD and HD groups with Vaspin and Endocan were 0.877、0.850,respectively(P<0.05), and the UA with HD and UA groups were 0.692、0.689,respectively(P<0.05).Conclusion: Vaspin and Endocan were related to the severity of cardiovascular disease and could be used for predicting the early prognosis in unstable angina combined with hypertension. 2019 Vol. 25 (2): 245-249 [Abstract] ( 89 ) HTML (1 KB)  PDF (1570 KB)  ( 233 ) 250 Effect of Thoracoscopic Surgery on IgA IgG IgM and Quality of Life in Patients with Early and Middle Thoracic Esophageal Cancer SI Panpan, NING Guangyao, LU Chen, et al DOI: 10.3969/j.issn.1006-6233.2019.02.020 Objective: To investigate the effects of thoracoscopic surgery on IgA, IgG, IgM and quality of life in patients with early and middle thoracic esophageal cancer, and to analyze the clinical effects. Methods: Eighty-four patients with lower thoracic esophageal cancer who were treated in our hospital from November 2015 to November 2016 were enrolled. The patients were divided into observation group (n=43) and control group (n=41) by simple random grouping. The control group underwent thoracotomy and the observation group underwent thoracoscopic surgery. Compare the operation time, intraoperative blood loss, hospitalization time, complete resection rate, compare the preoperative and postoperative immune function indexes immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), The quality of life index scores were changed. The 1st, 3rd, and 5th year survival rates were recorded. The incidence of complications such as chylothorax, pneumothorax, recurrent laryngeal nerve injury, anastomotic leakage, and arrhythmia were recorded. Results: The operation time and hospitalization time of the observation group were shorter than those of the control group (P<0.05). The intraoperative blood loss was lower in the observation group than in the control group (P<0.05). The complete resection rate was 93.33% in the observation group and 69.78% in the control group. The observation group was higher than the control group (P<0.05). After operation, the immune function indexes of IgA, IgG and IgM were decreased in the two groups, but the observation group was significantly higher than the control group (P<0.05). After operation, the quality of life indicators such as physical function, social function, material life and overall health of the two groups were improved, but the observation group was significantly higher than the control group (P<0.05). After the operation, the patient was given a 5-year telephone call. After follow-up, the results showed that the 1-year survival rate of the observation group was 93.02%, the 3-year survival rate was 81.39%, and the 5-year survival rate was 74.41%, which was significantly higher than the control group of 68.29%, 58.53%, and 48.78% (P<0.05). During the treatment, complication of chylothorax, pneumothorax, recurrent laryngeal nerve injury, anastomotic leakage and arrhythmia occurred in both groups. The total incidence of 8.89% in the observation group was significantly lower than that in the control group (34.88%) (P<0.05). Conclusion: Thoracoscopic surgery for patients with early and middle thoracic esophageal cancer can shorten the length of hospital stay, improve the surgical resection, reduce the immune function of the body, improve the quality of life, postoperative survival rate, and high safety. It is safe and effective. 2019 Vol. 25 (2): 250-254 [Abstract] ( 85 ) HTML (1 KB)  PDF (1289 KB)  ( 265 ) 255 Clinical Efficacy of Allergen Specific Immunotherapy for Allergic Rhinitis with Allergic Asthma YANG Dong, XING Yanfei, XIU Manxiang DOI: 10.3969/j.issn.1006-6233.2019.02.021 Objective: To study and analyze the therapeutic effect of specific immunity on allergic rhinitis with asthma and whether it is safe to use it widely in clinic. Methods: All patients were simple random grouping divided into two groups: immune group and symptomatic group. They were treated with standardized house dust mite allergen preparations and symptomatic drugs respectively. The severity of the disease and the use of drugs were evaluated before the start of the study, one year, two years and three years after the treatment. The adverse symptoms during the whole study were recorded in detail. Results: The nasal and asthmatic symptom scores and drug use scores of the two groups showed a significant downward trend (P<0.05), and the data of the symptomatic group were significantly higher than those of the immune group (P<0.05); the probability of adverse symptoms in the immune group was much lower than that in the symptomatic group (P<0.05). Conclusion: Specific immunotherapy for allergic rhinitis with asthma is better than symptomatic drugs, so it is more suitable for clinical use. 2019 Vol. 25 (2): 255-258 [Abstract] ( 71 ) HTML (1 KB)  PDF (1260 KB)  ( 248 ) 259 Correlation of Serum Sestrin2 levels with Severity and Prognosis of Acute Ischemic Stroke ZHANG Jinzhi, WANG Lijuan, ZHANG Xiao DOI: 10.3969/j.issn.1006-6233.2019.02.022 Objective: To analyze the relationship between the serum level of Sestrin2 and the severity and prognosis of acute ischemic stroke (AIS). Methods: A total of 98 patients with AIS who were admitted to the hospital during the period from January 2017 to January 2018 were included in the case group, and 40 persons who underwent physical examination in the same period were included in the control group. Serum Sestrin2 levels were determined by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). According to the National Institute of Health Stroke Scale (NIHSS), the patients were divided into mild, moderate and severe three subgroups. According to the modified Rankin (mRS) score at 3 months after discharge, the patients were divided into good prognosis group and poor prognosis group. The serum Sestrin2 levels were compared between subgroups. Results: The level of serum Sestrin2 in the case group was significantly higher than that in the control group [(13.90±2.54) ng/mL vs (11.76±1.41) ng/mL] (P<0.05). There were significant differences in serum Sestrin2 levels among the mild, moderate and severe groups (P<0.05), but there was no significant difference in the serum Sestrin2 level between the good prognosis group and the poor prognosis group [(13.69±1.95) ng/mL vs (14.60±2.38) ng/mL] (P>0.05). The serum Sestrin2 level was positively correlated with the NIHSS score (P<0.05) but not correlated with the mRS score (P>0.05). Conclusion: The level of serum Sestrin2 in patients with AIS is related to the severity of the disease, but there is no significant correlation with the prognosis. 2019 Vol. 25 (2): 259-261 [Abstract] ( 107 ) HTML (1 KB)  PDF (1252 KB)  ( 229 ) 262 Clinical Characteristics Analysis and the Change of Serums IL-6 and C-reactive Protein in Children with Henoch-Schonlein Purpura ZHENG Zhifang, CHEN Guoli, SUN Peng DOI: 10.3969/j.issn.1006-6233.2019.02.023 Objective:To study the clinical characteristics and to investigate the changes of serum levels of IL-6 and CRP in children of Henoch-Schonlein purpura(HSP). Methods:The 126 cases with HSP treated from June 1, 2015 to May 31, 2017, which were selected as the research objects, were divided into the group of patients with simple HSP (74 cases) and patients with HSP nephritis (52 cases) . All patients were retrospectively studied and clinical manifestations, cause of before the onset and starting symptoms. Meanwhile, the other 100 healthy medical examination children in our hospital during the same period were selected as the control group. The levels of IL-6 and CRP in the control group and experimental group were detected respectively. Results:①In the 126 cases of children with HSP, the average age of was 5.87±2.23 years old, from three to seven years old was accounted for 77.78%, and minimum age was 1 year 6 months. ②Infection was the major factor to induce HSP (55.56%); and food allergy was the second factor(14.29%). ③For starting symptoms, skin purpura was found in 78(61.90%) patients, which was for the first in HSP, especially for double lower limbs purpura. Renal involvement was found in 52(41.27%) patients. ④Serum levels of IL-6 and CRP of the patients with HSP before the treatment were higher than those of the normal control group(P<0.05). Serum levels of IL-6 and CRP were significantly higher in the patients with HSP nephritis than those in patients with simple HSP(P<0.05). The early disease recovery, levels of IL-6 and CRP were falling in the patients with HSP nephritis, but also higher than those of in patients with simple HSP(P<0.05). Conclusion:①The onset age of HSP was among school-age children and the most important inducing factor was infection. ②IL-6 and CRP participated in the pathological process of HSP, and dynamic testing the changing of levels of IL-6 and CRP in HSP could provide theoretical basis for clinical judgment condition. 2019 Vol. 25 (2): 262-264 [Abstract] ( 130 ) HTML (1 KB)  PDF (1251 KB)  ( 345 ) 265 Analysis on the Level of Palliative Care Demand and the Influencing Factors in Patients with Severe Chronic Obstructive Pulmonary Disease CHEN Xiaoshan DOI: 10.3969/j.issn.1006-6233.2019.02.024 Objective:To explore the level of demand and influencing factors for palliative care in patients with severe chronic obstructive pulmonary disease (COPD). Methods: A total of 180 patients with severe COPD were enrolled in our hospital from February 2015 to March 2018. The palliative care outcome scale (POS scale) was used to assess the level of palliative care needs, and the HAD anxiety and depression scale was used. Influencing factors of KPS card function scale and Borg scale on POS scale scores in patients with severe COPD. Results: In this study, 180 patients with severe COPD had an average POS score of 14.1 ± 5.3. Univariate analysis showed that gender, economic stress, duration of disease, pulmonary function, and comorbidities were all palliative care for patients with severe COPD. The correlation factors of the demand level were significantly different (P<0.05). The HAD score and Borg score of patients with severe COPD were positively correlated with the palliative care demand level. The KPS score was significantly negatively correlated with the palliative care demand level. The difference was significant. Sexuality (P<0.05); multivariate analysis showed that lung function grade, comorbidity type, and HAD score were the key factors affecting the level of palliative care in patients with severe COPD, and were significantly positively correlated with the level of palliative care needs of patients. Sex (P<0.05). Conclusion: Patients with severe COPD have higher palliative care services. Among them, the patient's lung function level, comorbidity type, anxiety and depression are important factors affecting the level of palliative care of such patients. Clinically, palliative care should be strengthened for such patients. The assessment of needs, the degree of progress of the patient's disease course is closely grasped, and the degree of attention to patient comfort and dignity is improved to improve the quality of life of patients with severe COPD. 2019 Vol. 25 (2): 265-268 [Abstract] ( 108 ) HTML (1 KB)  PDF (1240 KB)  ( 239 ) 269 Clinical Study of Chinese Medicine Dietary Regulation Combined with Meridian Pressure Exercise in Relieving Angina Pectoris of Coronary Heart Disease DAI Honghong, YAO Fumei, JI Huanchun DOI: 10.3969/j.issn.1006-6233.2019.02.025 Objective: To analyze the clinical effect of medicinal diet conditioning combined with meridian massage on relieving angina pectoris of coronary heart disease and its influence on patients'quality of life. Methods: A total of 134 patients with angina pectoris in our hospital were enrolled in the study. All patients were divided into control group (n=67 cases) and study group (n=67 cases) according to simple digital random method. The patients in the control group were given regular basic medication + traditional Chinese medicine diet. The patients in the study group were treated with meridian push-based operation on the basis of the control group. The nitroglycerin usage before and after the two groups were compared. The Seattle Angina Scale Scale (SAQ), The Health Status Questionnaire (SF-36) and the TCM Clinical Symptom Score were used to assess the post-treatment efficacy and impact on the patient's quality of life. Results: There was no significant difference in the amount of nitroglycerin before treatment, the Seattle Angina Scale Scale (SAQ), the Health Status Questionnaire (SF-36), and the TCM clinical symptom scores between the two groups (P>0.05). After treatment, the nitroglycerin dosage (40.31±9.36) mg, SAQ scale score (443.44±93.76), SF-36 score (515.82±53.46), and TCM clinical symptom score (3.52±2.64) were included in the study group. The amount of nitroglycerin (45.42±7.63) mg, SAQ scale score (389.59±92.08), SF-36 score (468.42±42.08), TCM clinical symptom score (4.81±2.64), between the two groups There were significant differences in the scores (P<0.05). Conclusion: The treatment of patients with coronary heart disease and angina pectoris treated with traditional Chinese medicine diet and combined with meridian push surgery can improve the patient's efficacy and quality of life, which is worthy of clinical promotion. 2019 Vol. 25 (2): 269-271 [Abstract] ( 104 ) HTML (1 KB)  PDF (1234 KB)  ( 216 ) 272 Heparin-free Dialysis and Filtration in the treatment of 60 cases of Uremia Complicated with Upper Gastrointestinal Bleeding DENG Cheng'ai, LU Lihua, WU Qi DOI: 10.3969/j.issn.1006-6233.2019.02.026 Objective: To observe the curative effect of heparin-free hemodiafiltration on uremia with upper gastrointestinal bleeding. Methods: 120 patients with uremia complicated with upper gastrointestinal bleeding in our hospital from January 2013 to January 2017 were randomly divided into two groups, 60 cases in each group. Group A was treated with local citrate anticoagulant hemodialysis, and group B was treated with heparin-free hemodiafiltration. The activated partial thromboplastin time (APTT), activated clotting time (ACT), pH of gastric juice, blood biochemical indicators and blood gas analysis before and after dialysis were compared between the two groups. The occurrence of dialyzer and tube coagulation in both groups was observed. Results: After dialysis, the APTT and ACT in group B were significantly shorter than those in group A (P<0.05), and the pH of gastric juice was significantly higher than that in group A (P<0.05). The levels of BUN and SCr in group B were significantly lower than those in group A (P<0.05). There were no significant differences in the level of Ca2+ or K+ or blood pH between the two groups (P>0.05). The HCO3- levels in group B were significantly lower than those in group A (P<0.05). There was no significant difference in the incidence of coagulation between group A and group B (10.00% vs 13.33%) (P>0.05). Conclusion: Heparin-free hemodiafiltration for uremia with upper gastrointestinal bleeding can effectively improve the renal function and pH of gastric juice, and correct potassium abnormalities. Local citrate anticoagulant hemodialysis is superior to heparin-free dialysis in terms of extracorporeal circulation. 2019 Vol. 25 (2): 272-275 [Abstract] ( 94 ) HTML (1 KB)  PDF (1258 KB)  ( 193 ) 276 Curative Effect of Pranoprofen combined with Carboxymethylcellulose Sodium Eye Drops in the treatment of Moderate to Severe Dry Eye FU Yu, CEN Yujian, FU Mi, et al DOI: 10.3969/j.issn.1006-6233.2019.02.027 Objective: To observe the clinical curative effect of pranoprofen combined with carboxymethylcellulose sodium eye drops in the treatment of moderate to severe dry eye. Methods: 100 patients with moderate to severe dry eye treated in the ophthalmology clinic of the hospital from January to August 2018 were randomly divided into the combined group (50 patients treated with pranoprofen combined with carboxymethylcellulose sodium eye drops) and the control group (50 patients treated with carboxymethylcellulose sodium eye drops). The SIT, BUT and FL scores before and after treatment, dry eye scores, curative effect and incidence of adverse reactions in both groups were observed. Results: The SIT, BUT and FL scores and dry eye score of the combined group were significantly lower than those of the control group after treatment (P<0.05). The cure rate and the total effective rate of the combined group were higher than those of the control group. The overall incidence of adverse reactions in the combined group was significantly lower than that in the control group (P<0.05). Conclusion: Praprofene combined with carboxymethylcellulose sodium eye drops is effective in the treatment of moderate to severe dry eye, with safety. 2019 Vol. 25 (2): 276-279 [Abstract] ( 94 ) HTML (1 KB)  PDF (1261 KB)  ( 252 ) 280 Effect of Loratadine combined with Montelukast Sodium on Serum ICAM-1 ECP EOS and CSF in Patients with Allergic Rhinitis LIU Yijun, ZENG Bangbing, ZENG Lang DOI: 10.3969/j.issn.1006-6233.2019.02.028 Objective: To investigate the effects of loratadine and montelukast on serum levels of ICAM-1, ECP, EOS and CSF in patients with allergic rhinitis. Methods: 104 cases of allergic rhinitis patients were from August 2013 to October to 2015 period in our hospital clinical cases, by drawing lots were randomly divided into the control group and the experimental group, 52 cases in each group. The control group received oral loratadine treatment, and the experimental group was treated with montelukast on the basis of the control group. The clinical efficacy, the levels of serum ICAM-1, ECP, EOS, CSF, nasal symptoms, VAS score and adverse reactions before and after treatment were compared between the two groups. Results: After treatment, the clinical efficacy of the experimental group (90.38%) was higher than that of the control group (80.77%), and the difference was statistically significant (P<0.05). There was no significant difference in serum ICAM-1, ECP, EOS and CSF levels between the two groups before treatment (P<0.05). After treatment, the VAS scores of the experimental group were significantly lower than those of the control group [(6.69 +2.08) VS (7.86 +2.69), (374.58 +69.83) VS (468.46 +80.53), (3.02 +0.88) VS (3.91 +0.89), (16.69 +3.47) VS (29.58 +5.73)]. After treatment, the nasal symptoms of the two groups were significantly lower than those of the control group. The adverse reactions in the experimental group were significantly lower than those in the control group, and there was no difference between the two groups (P>0.05). Conclusion: Loratadine combined with montelukast sodium has a definite therapeutic effect on allergic rhinitis. It can reduce the levels of serum ICAM-1, ECP, EOS and CSF, improve clinical symptoms, and is worthy of clinical application. 2019 Vol. 25 (2): 280-283 [Abstract] ( 85 ) HTML (1 KB)  PDF (1268 KB)  ( 296 ) 284 Efficacy and Prognosis of LVIS Stent Assisted Embolization for Intracranial Small Aneurysms LV Guangtao, WANG Haiquan, WANG Deming, et al DOI: 10.3969/j.issn.1006-6233.2019.02.029 Objective: To study the efficacy of LVIS stent assisted embolization for intracranial small aneurysms. Methods: Clinical data of 80 patients with intracranial small aneurysms who underwent LVIS stent-assisted embolization from April 2015 to April 2017were selected, the surgical outcome and prognosis were analyzed. Results: All 80 patients were successfully embolized, the success rate was 100%, immediate postoperative angiography showed that Raymond grade I embolism was 76.25% (61/80), grade II embolism was 21.25% (17/80), and grade III embolism was 2.50% (2/80), there was 1 cases of stent thrombosis occurred during operation, 2 cases of stent thrombosis occurred after post operation 72h, the incidence was 3.75% (3/80), no perioperative bleeding, transient or permanent neurological deficits and death occurred in all patients; the time from operation to discharge was 8~23d, with an average of (15.48±3.94) d. the Hunt-Hess classification improved significantly at discharge compared with admission(P<0.05); the follow-up time was 7~11 months, with an average of (9.34±1.24) months; during the follow-up period, the patients with Raymond grade I embolization remained stable without recurrence, the patients with grade II and III embolism had no aneurysm or aneurysm; the mRS score showed that there were 75 cases in 0 scores, 5 cases in 1~2 scores, and no case died during the follow-up period. Conclusion: LVIS stent assisted embolization is well for intracranial small aneurysms, the incidence of perioperative complications is low, the long-term prognosis is good, and the clinical value is high. 2019 Vol. 25 (2): 284-287 [Abstract] ( 113 ) HTML (1 KB)  PDF (1249 KB)  ( 256 ) 288 Curative Effects Observation of Coflex System Implantation and Fusion Technique in the Treatment of Elderly Lumbar Spinal Stenosis PAN Fujian, DUAN Yi DOI: 10.3969/j.issn.1006-6233.2019.02.030 Objective: To compare and analyze the short-term effects and follow-up results of Coflex system implantation and full laminectomy bone grafting fusion internal fixation (fusion technique) for elderly lumbar spinal stenosis (LSS). Methods: 72 elderly patients with LSS in our hospital were selected as the research subjects, and they were randomly divided into the control group and the observation group, whit 36 cases in each group. The control group was treated with fusion technique, and the observation group was implanted with Coflex system implantation. The operation condition, nerve function, pain improvement, postoperative complications and imaging indexes of the two groups were observed. Results:The operation time, intraoperative bleeding volume, the flow rate of wound and the hospitalization time in the observation group were significantly lower than those in the control group (P<0.05). The VAS scores of both groups decreased significantly at 3 months after operation (P<0.05). The JOA scores of the two groups increased significantly 6 months and 2 years after operation (P<0.05), and the change level of the observation group was significantly higher than that of the control group (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05). Two years after operation, there was no significant difference in the height of adjacent intervertebral space between the two groups (P>0.05). The activity of adjacent intervertebral space in the control group increased significantly (P<0.05). There was no significant change in the observation group (P>0.05). The activity of adjacent intervertebral space in the observation group was significantly lower than that in the control group (P<0.05). Conclusion:Coflex system implantation is an ideal short-term treatment for senile LSS. Two years follow-up shows that it can avoid the increase of adjacent segment intervertebral mobility to a certain extent, which is worthy of clinical application. 2019 Vol. 25 (2): 288-291 [Abstract] ( 79 ) HTML (1 KB)  PDF (1707 KB)  ( 233 ) 292 Effectiveness comparison of Erythropoietin and Mild Hypothermia in Full-term Neonates with Hypoxic-ischemic Encephalopathy SHANG Yun, et al DOI: 10.3969/j.issn.1006-6233.2019.02.031 Objective: To compare the efficacy of erythropoietin (EPO), mild hypothermia and their combination in the treatment of hypoxic-ischemic encephalopathy in full-term neonates.Methods:This study was a clinical experimental study. From January 2015 to January 2018, 100 children with moderate to severe HIE were randomly divided into routine group, EPO group, routine + EPO group, mild hypothermia group, routine + mild hypothermia group, combined group, routine + EPO + mild hypothermia group, normal healthy newborn group. In the control group, there were 25 persons in each group. The changes of serum IL-6 and TNF-a at admission and 72 hours after admission were compared, and the changes of neonatal neurobehavioral (NBNA) scores at 3 and 14 days after admission were compared. Results: The expression levels of IL-6 and TNF-a in routine group, EPO group, mild hypothermia group, combination group and control group decreased gradually. There were significant differences between the two groups (P<0.05). The NBNA score of newborns in four groups increased gradually after 14 days of admission, and there were significant differences between the two groups (P<0.05). Conclusion: Among various treatments, erythropoietin combined with mild hypothermia had the lowest levels of IL-6 and TNF-a, and the highest neurobehavioral score of newborns, suggesting that brain injury was the lightest and recovery was the fastest. It had the best therapeutic effect on neonatal hypoxic-ischemic encephalopathy, reducing brain injury, protecting nervous system and improving prognosis. 2019 Vol. 25 (2): 292-295 [Abstract] ( 90 ) HTML (1 KB)  PDF (1265 KB)  ( 269 ) 296 Effect of Breast Conserving Surgery and Delayed Immediate Reconstruction on Breast Cancer Patients WANG Longqing DOI: 10.3969/j.issn.1006-6233.2019.02.032 Objective: To investigate the effect of breast-conserving surgery and delayed immediate reconstruction on postoperative recovery, complications and quality of life of patients with breast cancer. Methods: The clinical data of 62 patients with breast cancer who were admitted to the hospital from July 2016 to December 2017 were retrospectively analyzed. They were divided into breast-conserving group and reconstruction group according to different surgical procedures. The breast appearance and quality of life were evaluated after surgery. The incidence of postoperative complications was recorded. All patients were followed up to record the local recurrence and distant metastasis. Results: The excellent and good rate of breast appearance in the breast-conserving group and the reconstruction group were 93.33% and 96.87%, respectively (P>0.05). The functional status score and additional attention score of the breast-conserving group were better than those of the reconstruction group (P<0.05). There was no significant difference in the total incidence of complications, long-term recurrence rate, local metastasis rate or survival rate between the two groups (P>0.05). Conclusion: Breast-conserving surgery and breast reconstruction can improve the breast appearance and quality of life of patients. There is no significant difference between the two in postoperative complications or long-term recurrence. The surgery can be chosen based on the patient's clinical data. 2019 Vol. 25 (2): 296-298 [Abstract] ( 118 ) HTML (1 KB)  PDF (1248 KB)  ( 196 ) 299 Analysis on the Cause of Acute Occlusion of Radial Artery After Radial Artery Puncture ZHAO Jie, LIU Jingyi, LIU Jiamei, et al DOI: 10.3969/j.issn.1006-6233.2019.02.033 Objective: To analyze the causes of acute occlusion of radial artery after radial artery puncture, and to speculate the possibility of occlusion after radial artery puncture by scientific means in clinical practice, so as to reduce the incidence of acute occlusion of radial artery. Methods: From June 2017 to May 2018, 845 consecutive patients underwent percutaneous coronary intervention through radial artery puncture in our hospital were enrolled. Radial artery pulsation was examined by two experienced doctors 72 hours after removing the sheath tube of the radial artery. The acute occlusion of the radial artery was determined by the decrease of oxygen saturation of the thumb and finger. The patients were divided into the radial artery occlusion group and the non-radial artery occlusion group. Clinical data were collected and analyzed statistically. Result: A total of 845 patients divided into radial artery occlusion group, n=46 and radial artery non-occlusion group n=799. By statistical analysis the ratio of female, the age, the medical history of hypertension, the medical history of hypertension diatebes, the medical history of hypertension of hypertriglyceridemia and the retention time of radial artery sheath are higher than in the radial artery non-occlusion group, P≤0.05. The difference was statistically significant. Conclusion: The causes of acute occlusion after radial artery puncture are closely related to females, seniors, hypertension, diabetes, hypertriglyceridemia and the time of radial artery puncture and catheterization. 2019 Vol. 25 (2): 299-302 [Abstract] ( 129 ) HTML (1 KB)  PDF (1256 KB)  ( 344 ) 303 Clinical Effect and Influencing Factors of Total Thoracoscopic Lobectomy combined with Systemic Lymphadenectomy in the treatment of Lung Cancer ZHANG Yin, YANG Min, WANG Jiaqi DOI: 10.3969/j.issn.1006-6233.2019.02.034 Objective: To investigate the clinical effect of video-asisted thoracoscopic surgery (VATS) combined with systematic lymphadenectomy in the treatment of lung cancer and the influencing factors. Methods: A total of 64 patients with lung cancer who were admitted to the hospital from January 2012 to July 2015 were enrolled in the study. They were divided into the observation group and the control group by the stratified random grouping, 32 cases in each group. The observation group was treated with VATS combined systematic lymphadenectomy, while the control group was treated with traditional open thoracotomy lobectomy and systemic lymphadenectomy. All patients were followed up for 3 years. Kaplan-Meier survival curve was used to analyze the median survival time and survival rate of both groups, and multivariate Cox regression analysis was performed to analyze factors affecting the clinical effect in the observation group. Results: The median survival time of the observation group was 27 months, and the 1-year, 2-year and 3-year survival rates were 87.50%, 68.75% and 40.63%. The median survival time of the control group was 25 months, and the 1-year, 2-year and 3-year survival rates were 84.38%, 62.50% and 34.38%. Kaplan-Meier survival curve analysis showed that there was no significant difference in overall survival time between the two groups (P>0.05). Univariate analysis showed that clinical stage, length of the lesion, tissue differentiation, number of lymph nodes removed and postoperative chemotherapy were closely related to the 3-year survival rates in the observation group (P<0.05). Multivariate Cox regression analysis showed that the clinical stage and the number of lymph nodes removed were independent factors influencing the prognosis in the observation group (P<0.05). Conclusion: The clinical effect of VATS combined with systematic lymphadenectomy is similar to that of traditional thoracotomy lobectomy combined with lymphadenectomy. Clinical stage and number of lymph nodes removed are independent influencing factors, which needs clinical attention. 2019 Vol. 25 (2): 303-306 [Abstract] ( 86 ) HTML (1 KB)  PDF (1357 KB)  ( 196 ) 307 Changes of Stress-related Indicators in Patients with Retroperitoneal Laparoscopic Renal Cyst Decompression and their Clinical Significance ZHENG Yanshen, MAI Huihong, LI Jianfeng, et al DOI: 10.3969/j.issn.1006-6233.2019.02.035 Objective: To analyze the changes in the level of stress-related markers in patients undergoing decompression of a new retroperitoneal renal cyst and its clinical significance. Methods: 120 patients with renal cysts who were examined in our hospital from July 2014 to March 2018 were randomly divided into study group and control group, each with 60 cases. The patients in the study group underwent single-hole laparoscopic resection of renal cysts and decompression. The patients in the control group underwent conventional retroperitoneoscopic renal cyst decompression. The clinical efficacy, body temperature, blood pressure, and blood glucose levels, cortisol, thyroid stimulating hormone (TSH), total triiodothyronine (TT3), and blood were compared before and after surgery on the 1st, 2nd, and 3rd days in the two groups of renal cyst patients. Total tetraiodothyronine (TT4) content, WBC and CRP levels, IL-6 and IL-8 levels, IgG, IgA and IgM levels, andCD4+,CD8+and CD4+/CD8+ ratios. Results: There was no significant difference in the operation time, length of stay, and blood loss between the study group and the control group. There was no significant difference between the two groups (P>0.05). The incidence of postoperative complications in study group and control group were 5.00% and 13.33%, respectively, and the difference between control group and study group was statistically significant (P<0.05); the study group and control group were postoperative There were significant differences in preoperative and postoperative blood glucose levels between 1st, 2d, and 3d (P<0.05). There was no significant difference in SBP and DBP between the two groups (P>0.05). There was a significant difference in the TT3 between the study group and the preoperative patients on the first postoperative day (P<0.05), but there was no statistically significant difference in the TSH, TT3, and TT4 levels between the two groups compared with the preoperative ones (P>0.05); The levels of CRP, IL-6 and IL-8 in the control group at the 1st, 2nd, and 3rd postoperative days were significantly different from those in the study group (P<0.05); There was no significant difference in the levels of IgG, IgA and IgM between the 2nd and 3rd day after operation (P>0.05). There was no significant difference in the levels of CD4 +, CD8 + and CD4 +/CD8+between the two groups on the 2nd and 3rd postoperative days (P>0.05). Conclusion: After retrograde decompression of a new type of retroperitoneal renal cyst, the changes in body temperature, blood pressure, blood glucose, WBC and CRP levels are smaller, and they have little impact on the patient's immune function, rapid recovery, and less trauma. 2019 Vol. 25 (2): 307-312 [Abstract] ( 83 ) HTML (1 KB)  PDF (1283 KB)  ( 186 ) 313 Observation of 308 nm Excimer Phototherapy for Vitiligo ZHOU Fen DOI: 10.3969/j.issn.1006-6233.2019.02.036 Objective: To analyze and discuss the effect of 308 nm excimer light on vitiligo. Methods: 250 patients with vitiligo admitted to our hospital from May 2013 to May 2018 were randomly divided into control group and experimental group according to random number table method. The patients in the control group were treated with 311 nm narrow-band ultraviolet radiation, while the experimental group was treated with 308 nm excimer light. The patients of two groups were treated twice a week, 30 times a week. The clinical efficacy of the two groups was evaluated. Results: After 3 courses of treatment, the effective rate of the control group was 46.40%, which was significantly lower than 57.60% of the experimental group (χ2=8.834, P<0.05). The average number of times of treatment was (9.24±4.11), significantly lower than that of the control group (12.37±3.94) (t=2.123, P<0.05). In the experimental group, the mean cumulative dose of efficacy was (7.38±4.72) J/cm2, significantly lower than that in the control group (29.88±8.56) J/cm2 (t=3.293, P<0.05). Conclusion: For vitiligo patients, 308 nm excimer phototherapy is more effective than 311 nm narrow-band ultraviolet irradiation, and the onset time is faster, which is worthy of clinical application. 2019 Vol. 25 (2): 313-315 [Abstract] ( 117 ) HTML (1 KB)  PDF (1235 KB)  ( 255 ) 316 Comparisons between Modified Kirschner Wire Cross-fixation and Traditional Kirschner Wire Cross-fixation in the treatment of Phalangeal Fractures ZHAO Zejin, et al DOI: 10.3969/j.issn.1006-6233.2019.02.037 Objective: To compare the clinical efficacy of modified Kirschner wire internal fixation with traditional Kirschner wire internal fixation for the treatment of phalangeal fractures. Methods: A retrospective analysis of 46 cases of phalangeal fractures admitted to our hospital from August 2015 to August 2017 was performed with modified Kirschner wire internal fixation or traditional Kirschner wire internal fixation. Among them, 25 patients underwent modified surgical method group (improved group) and 21 patients underwent traditional surgical method group (traditional group). The clinical efficacy of the two surgical Methods: was evaluated by observing the operation time, fracture healing time, and total finger active flexion (TAFS) score. Results: All patients were followed up for 12 to 24 months with an average of 16.7 months. In the traditional group, there were 2 cases of surgical failure, 19 cases of the result analysis, and 25 cases of the improved group all entered the result analysis. The results showed that the operation time of the improved group was significantly shorter than that of the traditional group. There was significant difference in the operation time between the two groups (P<0.05). There was no significant difference in the fracture healing time and TAFS score between the two groups (P>0.05). Conclusion In treating the phalangeal fractures, modified closed reduction percutaneous K-wire cross-fixation is better than traditional method. Conclusion: For the treatment of closed proximal and middle phalanx A fractures, modified Kirschner wire internal fixation has obvious advantages over traditional Kirschner wire internal fixation. 2019 Vol. 25 (2): 316-318 [Abstract] ( 65 ) HTML (1 KB)  PDF (1487 KB)  ( 173 ) 319 Study on the Effect of SMI Technique on the Detection of Sputum Microvascular Flow in Synovial Membrane of Knee Joint DU Jianwen, et al DOI: 10.3969/j.issn.1006-6233.2019.02.038 Objective: To investigate the effect of superb microvascularimaging(SMI) on the detection of microvascular blood flow signals in the synovial membrane of the knee joint.Methods: Forty-one patients with preoperative total knee arthroplasty were examined with power Doppler ultrasound (PDUS) and superb microvascular imaging (SMI). A total of 82 synovial membranes were detected in bilateral supracondylar sacs. At the same time, the distribution of blood vessels in 49 synovial pathological specimens of total knee arthroplasty was graded. The display rate of synovial grading between PDUS and SMI was compared, and the correlation between SMI classification and pathological grade was analyzed.Results: Among the 41 patients,49 knees undergoing total knee arthroplasty. The thickening synovial PDUS blood flow signal display rate was 84.1%,SMI blood flow signal display rate was 93.9%,χ2=3.994,(P<0.05).The consistency of PDUS and SMI synovial blood flow signal grading was Kappa=0.513. There was a positive correlation between SMI classification and synovial pathological grade rS=0.697,(P<0.05).Conclusion: Compared with PDUS,SMI has a high detection rate of synovial flow signals. There is a positive correlation between SMI classification and pathological grade. SMI technique has a good effect on the vasospasm of synovial membrane in RA patients. 2019 Vol. 25 (2): 319-321 [Abstract] ( 89 ) HTML (1 KB)  PDF (1219 KB)  ( 401 ) 322 Efficacy of Laparoscopic Myomectomy for Uerine Leiomyoma and Influence on Anti-Mullerian Hormone and Cervical Microcirculation CHEN Tiping, PENG Shihan, LUO Dan DOI: 10.3969/j.issn.1006-6233.2019.02.039 Objective: To investigate the efficacy of laparoscopic myomectomy for uterine leiomyoma and the influence on anti-Mullerian hormone (AMH) and cervical microcirculation. Methods: 95 patients with uterine leiomyoma admitted to our hospital from February 2015 to March 2018 were selected as the study subjects. They were randomly divided into observation group (n=50) and control group (n=45). The control group was treated with open hysteromyomectomy, while the observation group was treated with laparoscopic hysteromyomectomy. The operation time, hospitalization time, bleeding volume, recovery time of gastrointestinal tract, antimullerian hormone, follicle stimulating hormone (FSH), blood perfusion, capillary diameter, loop shape integral, blood flow integral and postoperative complications were compared between the two groups. Results: After treatment, operation time, hospital stay, blood loss and postoperative gastrointestinal recovery time of the observation group were significantly lower than those of the control group (P<0.05). There was no significant difference in AMH and FSH before treatment between the two groups. After treatment, AMH level in the observation group was significantly higher than that in the control group, and FSH level was lower than that in the control group (P<0.05). There was no significant difference between the two groups in the blood perfusion before treatment, capillary vessel diameter, and tubular loop shape integral and blood flow integral of nail fold microcirculation. After treatment, the shape integral and blood flow integral of the tubule loop in the blood perfusion and nail fold microcirculation were significantly lower in the observation group than in the control group, and the capillary diameter was higher than that in the control group (P<0.05). During the treatment, the total incidence of complications in the observation group was 4.00%, significantly lower than 22.22% in the control group (P<0.05). Conclusion: Laparoscopic myomectomy in patients with uterine leiomyoma has a significant effect, and has little effect on AMH level and cervical microcirculation. It is worth popularizing and applying. 2019 Vol. 25 (2): 322-324 [Abstract] ( 88 ) HTML (1 KB)  PDF (1239 KB)  ( 218 ) 325 Cytogenetic Analysis of Infertility between Bai Nationality and Han Nationality in Dali Bai, Yunnan ZHANG Lirong, ZHU Li, XU Anli, et al DOI: 10.3969/j.issn.1006-6233.2019.02.040 Objective: To analyze whether there is a difference in cytogenetic between infertility patients of Bai and Han nationality in Dali. Methods: G-band karyotype analysis was carry on peripheral blood lymphocytes in 1056 couples with infertility (422 were Bai female and 417 were Bai male; 634 were Han female and 639 were Han male). Results: The number of Bai infertile patients who carried abnormal chromosomes were 44, the detection rate was 5.13%, including 24 females and 19 males. The number of Han infertile patients who had abnormal chromosomes were 118,the detection rate was 9.27%, including 72 females and 46 males. There was a statistically significant difference in the detection rate of abnormal karyotypes between the two ethnic groups, but there was no difference in the sex ratio the of the abnormal karyotypes between the two groups. Conclusion:. The abnormal karyotype detection rate of Bai infertility patients is lower than that of Han patients in Dali, Yunnan.That may be related to the marriage customs, education level, occupation and living habits of Bai people in Dali. 2019 Vol. 25 (2): 325-327 [Abstract] ( 162 ) HTML (1 KB)  PDF (1236 KB)  ( 496 ) 328 The Relation between Plasma Glucose and Serum CA199 Levels in Physical Examination People NIE Qian, WANG Zhongli, HAO Zhihua, et al DOI: 10.3969/j.issn.1006-6233.2019.02.041 Objective: To investigate the relationship between plasma glucose and serum CA199 levels in physical examination people. Methods: A total of 2868 people aged 40-80 years were enrolled retrospectively from one medical center for physical examination of Hebei. According to CA199 level, all people were divided into negative group (<34U/ml) and positive group (≥34U/ml). Clinical data were compared between the two groups. The kinds of clinical data and the change of CA199 were compared according to different level of plasma glucose. Results: Compare with CA199 negative group, the levels of HbA1c, FPG, AST and ALT (P＜0.05) were significantly higher in CA199 positive group. The sex, age, BMI, SBP, DBP, TG, TC, LDL-C, HDL-C, BUN, Scr, SUA, γ-GGT, Hcy, WBC, NEUT, LYM between the two groups were no significant differences (P＞0.05). With the increase of HbA1c, the levels of CA199 were significantly higher (P＜0.01). Pearson analysis showed that the level of CA199 was positively correlated with FPG(r=0.272,P＜0.01), HbA1c(r=0.289, P＜0.01), AST(r=0.112, P＜0.01), ALT(r=0.087, P＜0.05). Multiple logistic regression analysis showed that FPG and HbA1c were associated with CA199 (OR=1.903,2.243,P=0.012,0.005) . Conclusion: The level of serum CA199 was affected by FPG and HbA1c in healthy people. Poor control of blood sugar was related to the increase of CA199. 2019 Vol. 25 (2): 328-331 [Abstract] ( 130 ) HTML (1 KB)  PDF (1252 KB)  ( 245 ) 337 Genital Tract Mycoplasma Infection in 227 Patients with Tubal Infertility in our Hospital and Results of Drug Sensitivity Test WANG Yuanyuan, et al DOI: 10.3969/j.issn.1006-6233.2019.02.044 Objective: To study the current status and drug resistance of genital tract mycoplasma infections in patients with tubal infertility. Methods: 227 patients with tubal infertility who were admitted to the hospital from January 2015 to June 2017 were included in the infertility group. 100 healthy female volunteers were selected as the control group at the same time. The cervical secretions were collected for mycoplasma culture, identification and drug sensitivity test. Results: A total of 129 cases with genital tract mycoplasma infection were detected in 227 patients with tubal infertility, including 66 cases with Ureaplasma urealyticum infection, 38 cases with Mycoplasma hominis infection and 25 cases with Ureaplasma urealyticum and Mycoplasma hominis infections. The total genital tract mycoplasma infection rate in the infertility group was significantly higher than that in the control group (56.8% vs 14.0%) (χ2=51.746, P=0.000). Ureaplasma urealyticum was most sensitive to doxycycline and mycophencin, and the sensitivity rate was 93.9%. The drug resistance to clarithromycin was the highest, and the drug resistance rate was 56.1%. Mycoplasma hominis was most sensitive to tetracycline and doxycycline, and the sensitivity rate was 94.7%. The drug resistance to roxithromycin was the highest, and the resistance rate was 68.4%. Ureaplasma urealyticum and Mycoplasma hominis were most sensitive to doxycycline, and the sensitivity rate was 88.0%,. The drug resistance to azithromycin was the highest, and the resistance rate was 92.0%. Conclusion:. Ureaplasma urealyticum infection is the main part of genital tract mycoplasma infection, showing multi-drug resistance. The clinical treatment should be guided by results of drug sensitivity test. 2019 Vol. 25 (2): 337-340 [Abstract] ( 94 ) HTML (1 KB)  PDF (1266 KB)  ( 291 ) 341 Effects of Perioperative Analgesia with Ropivacaine Combined with Sufentanil on Immune Function and Serum Tumor Markers in Patients Undergoing Radical Resection of Rectal Cancer TAN Guangye, YANG Yingchun, ZHOU Linrong, et al DOI: 10.3969/j.issn.1006-6233.2019.02.045 Objective: To observe the effects of ropivacaine lumbar muscle block (QLB) combined with sufentanil patient-controlled intravenous analgesia (PCIA) on immune function and serum tumor markers in patients undergoing radical resection of rectal cancer. Methods: 110 cases of patients undergoing elective radical resection of rectal cancer were selected and randomly divided into QLB group (n=55) and control group (n=55). QLB group was treated with QLB after general anesthesia induction (20ml of 0.375% ropivacaine per side), and control group was not given QLB, and they were given sufentanil PCIA after operation. The systolic blood pressure difference (ΔSBP), diastolic blood pressure difference (ΔDBP), heart rate difference (ΔHR) and postoperative pain visual analogue scale (VAS) score were compared between the two groups before and after slicing. The consumption amount of intraoperative fentanyl and postoperative sufentanil, compression time of first analgesic pump and remedial analgesia cases were recorded. The serum immunoglobulin (IgA, IgG, IgM), carcinoembryonic antigen (CEA), carbohydrate antigen125 (CA125) and CA199 were detected before operation and at 24h after operation. Results: Compared with control group, ΔSBP, ΔDBP and ΔHR were significantly decreased in QLB group (P<0.05), and the pain VAS scores were significantly decreased at 6h, 12h and 24h after operation (P<0.05). Compared with control group, the consumption amount of intraoperative fentanyl and the consumption amount of postoperative sufentanil were significantly decreased in QLB group (P<0.05), and the compression time of first analgesic pump was significantly later (P<0.05), and the proportion of remedial analgesia was significantly lower (P<0.05). The levels of serum IgA, IgG and IgM in both groups at 24h after operation were significantly lower than those before operation (P<0.05), and the changes in QLB group were smaller than those in the control group (P<0.05). There were no obvious changes in levels of CEA, CA125 or CA199 in the control group at 24h after operation, compared with those before operation (P<0.05). However, levels of CEA, CA125 and CA199 in QLB group were significantly lower than those before operation (P<0.05), and the changes were greater than the control group (P<0.05). Conclusion: Ropivacaine QLB combined with sufentanil PCIA can significantly reduce the consumption amount of opioids, improve the analgesic effects, reduce the immunosuppression, and effectively reduce the levels of serum tumor markers. 2019 Vol. 25 (2): 341-345 [Abstract] ( 98 ) HTML (1 KB)  PDF (1280 KB)  ( 213 ) 346 Effects of Ulinastatin on Inflammatory Factors Coagulation Function and Cognitive Function in Elderly Patients Undergoing Hip Replacement Surgery WEI Zhixian, PEI Zifeng DOI: 10.3969/j.issn.1006-6233.2019.02.046 Objective: To analyze the effects of ulinastatin on inflammatory factors, coagulation function and cognitive function in elderly patients undergoing hip replacement. Methods: A total of 128 elderly patients undergoing hip arthroplasty who were treated in our hospital from August 2016 to December 2017 were enrolled. All patients were divided into control group (n=64 cases) by random number table method. Study group (n=64 cases). Patients in the control group were given normal saline during the perioperative period, and patients in the study group were given ulinastatin during the perioperative period. Venous blood was collected from all patients before and immediately after surgery, 1, 2, and 3 days to detect interleukin-6 (IL-6), detect interleukin-8 (IL-6), and CRP levels; Prothrombin time (PT), partial thrombin time (APTT), thrombin time (TT) were measured at 3 days after surgery and cognitive function was assessed by the patient's simple intelligence state test (MMSE).Results: The levels of IL-6, IL-6 and CRP in the two groups reached a peak after the operation, and then gradually decreased. However, the postoperative study group was lower than the control group, and IL-8 and CRP were in operation. Immediately after and 1 and 2 days after surgery, the difference was statistically significant (P<0.05). At 3 days after operation, the PT, APTT and TT of the study group were significantly better than the control group, and the difference was statistically significant (P<0.05). The MMSE score of the control group was significantly lower than that of the preoperative group, and the difference was statistically significant (P<0.05).Conclusion: Ulinastatin can improve the hypercoagulable state of patients with senile hip replacement by inhibiting inflammatory reaction, and effectively prevent postoperative cognitive dysfunction. It is worthy of clinical promotion. 2019 Vol. 25 (2): 346-348 [Abstract] ( 95 ) HTML (1 KB)  PDF (1242 KB)  ( 187 ) 349 Correlation on Detection of Low Density Lipoprotein Cholesterol and Plasma D-dimer Levels in Patients with Coronary Heart Disease ZHU Yanzhong, SONG Cheng DOI: 10.3969/j.issn.1006-6233.2019.02.047 Objective: To study the clinical value of pediatric low density lipoprotein cholesterol (sdLDL-C) and plasma D-dimer levels in physical examination of coronary heart disease patients. Methods: A total of 200 patients with coronary artery disease diagnosed in our hospital from October 2015 to October 2017 were selected as the observation group, including 66 patients with unstable angina (UAP), 56 patients with myocardial infarction (AMI), and stable angina pectoris. 78 patients (SAP) were included in the same period as 50 control subjects. The total cholesterol (TC), triglyceride (TG), serum sdLDL-C, and high-density lipoprotein cholesterol (HDL-C) were measured. Low-density lipoprotein cholesterol (LDL-C), plasma D-dimer and homocysteine (Hcy) levels. Results: The levels of TC, TG, serum sdLDL-C, LDL-C, HDL-C, Hcy and plasma D-dimer in the observation group were significantly higher than those in the control group (P<0.05). The comparison between the AMI group and the SAP group showed that the levels of sdLDL-C and D-dimer were significantly higher than those of the SAP group (P<0.05). The comparison between the UAP group and the SAP group showed no significant difference in the level of sdLDL-C. (P>0.05), but at the D-dimer level, UAP group was significantly higher than SAP group (P<0.05); AMI and UAP group data showed that there was no significant difference in sdLDL-C level (P>0.05) In addition, the comparison showed that D-dimer levels were higher than those in the UAP group (P<0.05). Conclusion: Detection of sdLDL-C and D-dimer can effectively reflect the specific condition of patients with coronary heart disease, and have important application value for the early diagnosis and prediction of coronary heart disease and clinical classification. 2019 Vol. 25 (2): 349-352 [Abstract] ( 114 ) HTML (1 KB)  PDF (1246 KB)  ( 412 )

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