Home  |  About Us  |  Editorial Board  |  Instruction  |  Subscribe  |  Advertisement  |  Messages  |  Contact Us  |  中文

Office Online         Journal Just Accepted Current Issue Archive Advanced Search Most Read Most Download Email Alert            Download More...              Links More...

2018 Vol. 24, No. 7 Published: 2018-07-20 1057 Clinical Effect of PVP and PKP in the Treatment of Osteoporotic Vertebral Compression Fractures and Its Influence on VAS and ODI Index of Patients LI Zesen, ZENG Qiao DOI: 10.3969/j.issn.1006-6233.2018.07.001 Objective: To analyze the clinical effect of PVP and PKP in the treatment of osteoporotic vertebral compression fractures and the influence on VAS and ODI, and to explore its clinical applicability. Methods: 86 patients with osteoporotic vertebral compression fractures were selected from January 2015 to January 2017 in our hospital, and they were simple randomly divided into the observation group of 43 cases and the control group of 43 cases by the number of hospitalized. The control group was given PVP treatment, and the observation group was treated with PKP. The patients in the two groups were followed up for 10 months. And the operation situation of the two groups of patients, recovery of vertebral body (Cobb angle and vertebral compression rate) before and after surgery were observed; and VAS and ODI were used to evaluate the improvement of vertebral function and bone cement leakage in the two groups. Results: The patients with operation process of two groups were very smooth, no nerve root and spinal cord injury and death and other adverse events, during the operation of the patients of two groups were successfully punctured, the observation group of unilateral puncture 25, bilateral puncture 18; control group with unilateral puncture 26, bilateral puncture 17.The operation time and the amount of bone cement in the observation group were higher than those in the control group (P<0.05). The patients with anterior Cobb angle of two groups, vertebral compression rate, VAS and ODI were no different before the surgery (P>0.05). Cobb angle, vertebral compression rate, VAS score and ODI index of the patients of two groups after treatment were significantly decreased (P<0.05); and the examination indexes in the observation group and the control group of patients after surgery were no significant difference (P>0.05), but after 10 months of follow-up, the observation group of patients with Cobb angle and the vertebral compression rate and VAS score was slightly lower than that of the control group (P<0.05). The patients in the observation group after bone cement leakage occurred in 2.33%, 13.95% in the control group and the difference was statistically significant (χ2=3.8912, P=0.0486). Conclusion: The clinical effect of PVP and PKP in the treatment of osteoporotic vertebral compression fractures are significantly, and the postoperative effect is the same, but the fracture healing is good. The incidence of cement leakage is low of PKP by followed up postoperatively, and the long-term prognosis effect is obvious. 2018 Vol. 24 (7): 1057-1059 [Abstract] ( 79 ) HTML (1 KB)  PDF (1263 KB)  ( 202 ) 1060 Application of Neuroendoscopy in the Treatment of Hypertensive Intracerebral Hemorrhage and its Effects on Serum SF MBP and GFAP ZHU Bin, CHEN Wei, XU Fengke, et al DOI: 10.3969/j.issn.1006-6233.2018.07.002 Objective: To study the application of neuroendoscopy on hypertensive intracerebral hemorrhage and its effects on serum ferritin (SF), myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP). Methods: 78 patients with hypertensive intracerebral hemorrhage admitted to our hospital from August 2014 to July 2015 were randomly divided into observation group and control group, 39 cases in each group. The observation group completed the treatment with neuroendoscopy, and the control group were taken the big bone flap craniotomy to complete the treatment. The clinical curative effect, intraoperative and postoperative situation, serum SF, MBP and GFAP levels were compared between the two groups. Results: After treatment, the total effective rate in the observation group was significantly higher than that in the control group (P<0.05). The skin incision length, cortical incision length, bone window size, operation time and blood loss in observation group were significantly less than those in control group (P<0.05). There was no significant difference in hematoma clearance rate, rebleeding rate, intracranial infection rate and mortality between the two groups (P>0.05). Before operation, there was no significant difference in serum SF, MBP and GFAP between the two groups (P>0.05). After operation, serum SF, MBP and GFAP levels in both groups were significantly lower than those before operation (P<0.05) , observation group were lower than the control group (P<0.05). Conclusion: Neuroendoscopy in the treatment of hypertensive intracerebral hemorrhage, can effectively reduce the serum levels of SF, MBP, GFAP, shorten the skin incision length, cortical incision length, operation time, reduce blood loss, clinical efficacy is good, is conducive to the prognosis of patients. 2018 Vol. 24 (7): 1060-1063 [Abstract] ( 100 ) HTML (1 KB)  PDF (1318 KB)  ( 207 ) 1064 The Diagnostic Value of Virtual Touch Tissue Quantification and Transrectal Ultrasonography in Prostatic Cancer ZHAO Ling, et al DOI: 10.3969/j.issn.1006-6233.2018.07.003 Objective: To analyze comparatively the diagnostic value of virtual touch tissue quantification (VTTQ) and transrectal ultrasonography (TRUS) in prostatic cancer. Methods: 78 cases of patients with Prostate disease received from January 2016 to September 2017, according to the result of transrectal prostate biopsy, it was divided into prostate hyperplasia group 46 cases and prostate cancer group 32 cases. In the same period, 35 healthy volunteers were included in the control group. All of them were examined by TRUS, at the same time, VTTQ was used to detect the shear wave velocity (SWV) of the prostate tissue, comparative analysis of the efficacy of VTTQ and TRUS in the diagnosis of prostate cancer. Results: The SWV in the prostate cancer group and the prostatic gland hyperplasia group and was significantly higher than that in the control group (P<0.05), the prostate cancer group was significantly higher than the prostatic gland hyperplasia group (P<0.05). When SWV=2.23m/s, the sensitivity, specificity and accuracy of VTTQ in the diagnosis of prostate cancer are 84.38%,86.96%,85.90%, the sensitivity, specificity and accuracy of TRUS in the diagnosis of prostate cancer are78.13%,65.22%,70.51%, there was no significant difference in the sensitivity of VTTQ and TRUS in the diagnosis of prostate cancer (P>0.05). The specificity and accuracy of VTTQ in the diagnosis of prostate cancer were significantly different from those in TRUS (P<0.05). Conclusion: Compared with TRUS, VTTQ has a better diagnostic value for the prostatic cancer, with higher diagnostic specificity and accuracy. 2018 Vol. 24 (7): 1064-1067 [Abstract] ( 153 ) HTML (1 KB)  PDF (1377 KB)  ( 521 ) 1068 Effect of Bladder Filling Degree on Target Location in Radiotherapy of Cervical Cancer ZHAO Jing, et al DOI: 10.3969/j.issn.1006-6233.2018.07.004 Objective: To explore the effect of different bladder filling degree on target location in radiotherapy of cervical cancer patients, and to provide reference for clinical application. Methods: A total of 8 patients with cervical cancer who were treated in the first phase of IIB IIIB in our hospital from June 2016 to June 2017 were collected. CT scan was performed in the bladder filling, half filling and vacuity state respectively, and the location of the target area in the different filling states of the cervix and uterus was analyzed. Results: The relative displacement of cervix and uterus in the different filling state of the bladder chould lead to relative bone signs. The change of left and right direction was the smallest. The largest lesion of cervical lesion was 1.5mm. It changed greatly in the direction behind chest. With the increase of bladder capacity, the cervical lesions moved towards the back of the body. The maximum range was 19mm. In the head foot direction during bladder filling degree and half filling degree of the movement of the cervical lesions was statistically significant (P<0.05), at half filling degree and the degree of cervical lesions empty mobility was statistically significant (P<0.05), and with the increase of bladder filling degree of cervical lesions generally to the foot direction body displacement, maximum the amplitude of 18.6mm.The palace of the movement of the influence in the chest behind the relatively large, with the increase of bladder filling degree, the palace body generally to the dorsal movement of the body, the maximum amplitude was 21mm, relatively small in the direction of change, the maximum amplitude of 1.2mm and different degree of bladder filling in the head foot direction opposite to the movement of a body significantly, and increase with the degree of bladder filling, the palace body generally to the head direction of the body displacement, the maximum amplitude of 13mm. Conclusion: In the radiotherapy of cervical cancer, we need to consider the different degree of bladder filling to move the cervical and uterine body position, so as to reduce the deviation of target area and protect normal tissues. 2018 Vol. 24 (7): 1068-1071 [Abstract] ( 119 ) HTML (1 KB)  PDF (1310 KB)  ( 197 ) 1072 Effect of Nicorandil combined with Trimetazidine on Serum hs-CRP ESM-1 EMPs of Emergency Patients with AMI After PCI WANG Qisheng, WANG Shaobo, DUAN Yunxiang DOI: 10.3969/j.issn.1006-6233.2018.07.005 Objective: To study the effect of nicorandil combined with trimetazidine on serum high sensitive C reactive protein(hs-CRP), endothelial cell specific molecules-1(ESM-1), endothelial cell particles (EMPs) and in patients with acute myocardial infarction after emergency percutaneous coronary intervention(PCI). Methods: 92 patients of acute myocardial infarction received therapy from October 2015 to October 2017 in our hospital were selected as research objects. According to random number table, those patients were divided into the observation group (n=46) and the control group (n=46), they were performed emergency PCI operation, and were given routine treatment during the perioperative period, the control group was treated with trimetazidine, while the observation group was combined with nicorandil, continuous use of 7 days. The electrocardiogram effect, the changes of cardiac function, hs-CRP, ESM-1 and EMPs before PCI and after treatment 7 days were compared between the two groups, and the incidence of adverse cardiovascular events in the after operation 30d was compared. Results: After 7 days treatment, the total effective rate in the observation group was 93.48% (43/46), which was significantly higher than that of the control group 73.91% (34/46) (P<0.05); after 7d treatment, the index of cardiac function in the two groups was significantly improved than that before PCI (P<0.05), and the left ventricular end diastolic diameter (LVDD), left ventricular end systolic diameter (LVDS), left ventricular end diastolic volume (LVEDV) and left ventricular end systolic volume (LVESV) in the observation group were significantly lower than those in the control group, the left ventricular ejection fraction (LVEF) was significantly higher than those in the control group (P<0.05); after treatment 7d, the serum hs-CRP, ESM-1, and EMPs in the two groups were significantly lower than those before the PCI (P<0.05), and the serum hs-CRP, ESM-1 and EMPs in the observation group were significantly lower than those in the control group[(6.84±1.19)mg/L vs(8.94±1.46)mg/L,(0.89±0.11)μg/L vs(1.16±0.15)μg/L,(820.18±113.49)number/μL vs(1017.35±120.47)number/μL](P<0.05); the total incidence of emergency coronary artery revascularization, recurrent myocardial infarction, stroke and cardiogenic death in the two groups was 4.35% and 13.04%, there was no significant difference (P＞0.05). Conclusion: Nicorandil combined with trimetazidine is well for acute myocardial infarction after PCI, which can effectively improve the postoperative cardiac function, and the short-term prognosis is good, it's intrinsic mechanism may reduce the expression of serum hs-CRP, ESM-1 and EMPs. 2018 Vol. 24 (7): 1072-1077 [Abstract] ( 97 ) HTML (1 KB)  PDF (1342 KB)  ( 164 ) 1078 Effect of Danhong Injection combined with Valsartan on Efficacy and Related Factors in Patients with Chronic Renal Failure WANG Liping, WU Gang, LIAO Zhimin, et al DOI: 10.3969/j.issn.1006-6233.2018.07.006 Objective: To study the effect of Danhong injection combined with valsartan on chronic renal failure and its related factors. Methods: 90 patients of chronic renal failure received therapy from March 2015 to March 2016 in our hospital were selected as research objects. According to the draw method divided into control group(n=45) and treatment group(n=45). Two groups of patients were treated with conventional treatment. The control group was treated with valsartan, 80mg per day, once a day. While the treatment group, on the basis of control group, treated with Danhong injection, 40mg per day, Add 5% glucose injection 200mL and mix intravenously, once a day. The two groups were treated for one month. Then treatment effect, clinical symptom score, renal function index, the level of 24 h urinary albumin (UAE), blood urea nitrogen (BUN), serum creatinine (SCr), the serum level of TGF-1, beta 1, VEGF, MCP-1, ANG II of two groups were compared. Results: The total effective rate of the treatment group was significantly higher than that of the control group(P<0.05); Lassitude, anorexia, clear night urine scores were significantly lower than the control group(P<0.05); The levels of UAE, BUN and Cr were significantly lower than those of the control group(P<0.05); The levels of TGF-1, beta 1, VEGF, MCP-1 and ANG II were significantly lower than those of the control group(P<0.05). Conclusion: Danhong injection combined with valsartan is well for chronic renal failure, which can improve the clinical symptoms, reduce urinary protein, improve the microcirculation of the kidney, and protect the renal function. It can significantly reduce the levels of serum TGF-β1, VEGF, MCP-1, ANG II, and alleviate the development of the disease. 2018 Vol. 24 (7): 1078-1080 [Abstract] ( 107 ) HTML (1 KB)  PDF (1302 KB)  ( 189 ) 1081 Effect of Tongxinluo Capsule combined with Dual Antiplatelet Regimen on the Prognosis of Patients with Aspirin Resistance after PCI WANG Feng, ZHAO Ruonan DOI: 10.3969/j.issn.1006-6233.2018.07.007 Objective: To explore the effect of Tongxinluo capsule combined with dual antiplatelet regimen on the prognosis of patients with aspirin resistance (AR) after percutaneous coronary intervention (PCI). Methods: 100 patients with coronary heart disease (CHD) who had AR after undergoing PCI in the hospital from February 2012 to April 2016 were selected as the subjects. They were randomly divided into the control group and the observation group by the random number table method, 50 cases in each group. The control group was treated with dual antiplatelet regimen, and on the basis, the observation group was treated with Tongxinluo capsule. The degree of platelet aggregation, serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) levels were measured at different time. Changes of cardiac function in patients were determined by echocardiography, and the relief of symptoms of angina pectoris was observed. The two groups were followed up for 1 year, and the incidence of adverse cardiovascular events was statistically analyzed. Results: After 4 weeks of treatment, the platelet aggregation rates of the two groups decreased to varying degrees (P < 0.05), and the platelet aggregation rates induced by AA and ADP in the observation group were lower than those in the control group (P < 0.05). Before treatment, there was no significant difference between the two group in serum lipids or cardiac function indexes (P > 0.05). After 6 months of treatment, the TC, TG, LDL and LVESD in the two groups were decreased, while HDL and LVEF were increased (P < 0.05). The TC, TG, LDL and LVESD in the observation group were lower than those in the control group while HDL and LVEF were higher than those in the control group (P < 0.05). The scores of angina pectoris in the two groups were increased after 6 and 12 months of treatment, and the scores of the observation group were higher than those of the control group (P < 0.05). The incidence of adverse events in the observation group during 1-year follow-up was slightly lower than that in the control group, but there was a significant difference only in the readmission rate (P < 0.05). Conclusion: Tongxinluo capsule combined with dual antiplatelet regimen can improve the blood lipid levels and cardiac function, relieve angina pectoris symptoms, reduce the incidence of cardiovascular adverse events, and improve the prognosis of patients with AR after PCI. 2018 Vol. 24 (7): 1081-1085 [Abstract] ( 148 ) HTML (1 KB)  PDF (1340 KB)  ( 372 ) 1086 Anesthesia Effects of Propofol-ruifendanil or Sevoflurane-ruifentanil during the Laparoscopic Hysterectomy SUN Wangchun DOI: 10.3969/j.issn.1006-6233.2018.07.008 Objective: To explore the anesthesia effects of propofol-ruifentanil and sevoflurane-ruifentanil druing the laparoscopic hysterectomy and the influence on pneumodynamics. Methods: 106 cases of patients with laparoscopic hysterectomy in our hospital were selected as the research object, and were divided into sevoflurane group (n=53) and propofol group (n=53) according to the random number table. Two groups were induced by ruifentanil anesthesia, propofol group was given propofol to maintain anesthesia, while sevoflurane group was treated with sevoflurane anesthesia. The effects of 2 groups were compared, and the changes of pneumodynamics indexes were compared between 2 groups. Results: There was no significant difference in anesthesia maintenance time between sevoflurane group and propofol group (P>0.05), but the spontaneous breathing recovery time, recovery time, extubation time, verbal response time, eye opening time of sevoflurane group were earlier than propofol group (P<0.01); compared with after intubation 5 min, Paw and PIP of 2 groups after pneumoperitoneum 10 min and after pneumoperitoneum 30 min significantly increased, Cdyn decreased significantly (P<0.01), and Paw of treatment group was lower than that of control group (P<0.05); there was no significant difference in Paw, PIP, Cdyn between 2 groups after pneumoperitoneum 5 min and after minintubation 5 min (P>0.05); There was no significant change in the BIS between 5 min after intubation and 5 min after pneumoperitoneum in both groups (P>0.05), but the BIS value in sevoflurane group was significantly higher than that in propofol group (P<0.01). There was no significant difference in the MAP, CO, SVR and ACI after intubation 5 min between the 2 groups (P>0.05), compared with after intubation 5 min, the MAP and SVR levels after pneumoperitoneum 10 minutes and after pneumoperitoneum 30 min increased significantly, the SVR significantly increased in 2 groups (P<0.01), the ACI of sevoflurane group was lower than that of propofol group (P<0.01); There was no significant difference in CO between 2 groups at different time points and between groups (P>0.05). Conclusion: Sevoflurane combined with remifentanil and propofol combined with remifentanil during laparoscopic hysterectomy has a same anesthesia time, and has effect on pneumodynamics after establishing pneumoperitoneum, but sevoflurane combined with remifentanil can make the patients in a shorter period of time to recover and restore consciousness, reduce lung injury, and the effect on hemodynamics was relatively small. 2018 Vol. 24 (7): 1086-1090 [Abstract] ( 79 ) HTML (1 KB)  PDF (1333 KB)  ( 126 ) 1091 Effect of Percutaneous Vertebroplasty at Low Temperature in the treatment of Multisegmental Osteoporotic Vertebral Fractures ZHAO Shengjun, et al DOI: 10.3969/j.issn.1006-6233.2018.07.009 Objective: To evaluate the effect of percutaneous vertebroplasty at low temperature in the treatment of multisegmental osteoporotic vertebral fractures. Methods: 87 cases of senile osteoporosis vertebral compression fractures (OVCFs) with more than 2 vertebral body were retrospectiveiy analyzed, which adopting low-temperatured, staged and unilateral-punctured injection of the percutaneous kyphoplasty (PKP) in Chengde Central Hospital from January 2006 to October 2016. Preoperative and postoperative visual analogue scale (VAS), postoperative Cobb angle improvement, the oswestry disability index (ODI) and cement extravasion were analyzed to assess the curative effectiveness. Results: 87 patients with unilateral pedicle puncture technique, the success rate was 100%.The VAS scores of preoperative and 1day, 3 months and 6 months after surgery were (7.7 ± 1.0),(2.5 ± 0.8),(2.4 ± 0.7)and(2.1 ± 0.7). Postoperative Cobb angle: (24.6 ± 4.7),(12.9 ± 2.1),(12.6 ± 2.0),(13.0 ± 2.2)°.ODI scores were(77.3 ± 8.4),(30.7 ± 6.5),(27.5 ± 6.6),(27.4 ± 6.1)%. Bone cement leakage: 3 cases without clinical symptoms. Conclusion: The low-temperatured and staged injection of the percutaneous kyphoplasty (PKP) in the treatment of multiple-segmental senile osteoporosis vertebral compression fractures (OVCFs) can reduce the cement extravasion rate, relieve pain rapidly, improve the quality of life and thus achieve satisfactory clinical effectiveness 2018 Vol. 24 (7): 1091-1095 [Abstract] ( 69 ) HTML (1 KB)  PDF (2777 KB)  ( 151 ) 1096 Effects of Enoxaparin Combined with Ulinastatin on the Thrombogenesis and Serum RANKL, OPG and MMP-9 Levels of Patients after Knee Arthroplasty PENG Xiong, CHEN Jialian DOI: 10.3969/j.issn.1006-6233.2018.07.010 Objective: To study the effect of enoxaparin combined with ulinastatin on the thrombus prophylaxis and the serum factor-1 receptor activator ligand (RANKL), osteoprotegerin (OPG), matrix metalloproteinase -9 (MMP-9) levels of patients after knee arthroplasty. Methods: From July 2015 to June 2016, 80 patients with knee replacement were included in this study in our hospital, and divided into the observation group and control group according to the admission order with 43 cases in each group. The control group was treated with enoxaparin sodium for injection on the basis of knee arthroplasty. The observation group was treated with ulinastatin on the basis of control group. The changes of serum PANKL, OPG, MMP-9 levels, coagulation function indexes before and after treatment, postoperative thrombosis and the incidence of adverse reactions were compared between the two groups. Results: The levels of serum PANKL, OPG and MMP-9 in the two groups after treatment were significantly lower than those before operation (P <0.05). Compared with the control group, the serum PANKL level in the observation group was higher (P <0.05), the serum OPG and MMP-9 levels were lower (P <0.05). There was no significant difference in the D-dimer, platelet, partial thromboplastin time, calf muscle vein thrombosis, deep vein thrombosis and thrombosis length between the two groups (P> 0.05). The proportion of thrombus, the total length of the thrombus, the number of thrombosis in the observation group were significantly lower than those of the control group (P<0.05). The was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Enoxaparin combined with ulinastatin can effectively prevent the thrombogenesis of lower extremities after knee arthroplasty, which can effectively reduce the serum levels of PANKL, OPG and MMP-9 with high safety. 2018 Vol. 24 (7): 1096-1099 [Abstract] ( 83 ) HTML (1 KB)  PDF (1307 KB)  ( 210 ) 1100 Curative Efficacy of Insulin Sensitizer in Treatment of Type 2 Diabetes Intensive Treatment after Long-term Remission and its Effects on Urine Microalbumin CHEN Hongxia, et al DOI: 10.3969/j.issn.1006-6233.2018.07.011 Objective: To study curative efficacy of insulin sensitizer in treatment of type 2 diabetes intensive treatment after long - term remission and its effects on urine microalbumin. Methods: 80 patients of type 2 diabetes mellitus who received therapy from April 2015 to April 2016 were selected as research objects. According to random number table method,those patients were divided into the observation group(n=40) and the control group(n=40). The control group was treated with secondary double-arc treatment,while the observation group was treated with Insulin sensitizer treatment.Then blood sugar,insulin,C peptide,HDL-C, LDL-C, Homa-IR and UAE level were compared. Results: After treatment,the level of FBG and PBG in observation group was less than the control group after 1 month and 2 months(P<0.05). There was no significant difference in HbA1c levels between the two groups after 1 and 2 months of treatment(P>0.05). Two groups of FINS levels in the treatment of 1, 2 months after the decline. There were no significant differences in FINS, PINS, FC-P and PC-P between the two groups after 1 and 2 months (P> 0.05). HDL-C indicator in Observation group was higher than the control group[(1.51±0.55) mmol/L vs(1.27±0.46)mmol/L](P<0.05). LDL-C indicator in Observation group was less than the control group[(2.92±0.71) mmol/L vs(3.36±0.79)mmol/L](P<0.05). UAE level in Observation group was less than the control group [(98.27±56.23) C/mg.(24h)-1vs(143.22±51.37) C/mg。(24h)-1](P<0.05). Conclusion: Insulin sensitizer treatment of type 2 diabetes can effectively reduce the level of blood glucose and FINS, so that the sensitivity of peripheral tissue in the insulin to improve and reduce the level of urinary albumin in patients with significant efficacy, worthy of promotion. 2018 Vol. 24 (7): 1100-1103 [Abstract] ( 91 ) HTML (1 KB)  PDF (1320 KB)  ( 145 ) 1104 Effects of Salvianolate Combined with Mecobalamin on Serum IGF-1 IGFBP-1 BDNF MBP and Peripheral Nerve Conduction Velocity in Patients with Diabetic Peripheral Neuropathy KE Li Mu-Palida, BAI Tingdina, MAO Wenjuan DOI: 10.3969/j.issn.1006-6233.2018.07.012 Objective: To study the effects of salvianolate combined with mecobalamin on serum insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 1 (IGFBP-1), human brain-derived neurotrophic factor (BDNF ), Human myelin basic protein (MBP) and peripheral nerve conduction velocity. Methods: A total of 136 patients with diabetic peripheral neuropathy who were treated in our hospital from September 2015 to October 2017 were selected for study. They were randomized into observation group (69 cases) and control group (67 cases). The patients in the control group were treated with mecobalamin, while the observation group was treated with salvianolate in the control group. The IGF-1, IGFBP-1, BDNF, MBP, MCV, SCV, fasting blood glucose, and postprandial blood glucose levels were recorded before treatment, 10 days after treatment, and 20 days after treatment, as well as the quality of life after treatment. And compare the two groups of changes, and then make a comprehensive evaluation of clinical efficacy. Results: The total effective rate in the observation group was significantly higher than that in the control group [92.75%>76.12%] (P<0.05); at 10 days after treatment and 20 days after the treatment, the levels of IGF-1, BDNF, MCV, and SCV were higher in the two groups of patients. Significantly increased before treatment, and the observation group was higher than the control group (P<0.05); IGFBP-1, MBP, fasting blood glucose, 2h postprandial blood glucose levels and quality of life scores were significantly lower in the two groups than before treatment, and the observation group Lower than the control group (P<0.05). Conclusion: Salviae miltiorrhizae polyphenols combined with mecobalamin treatment of diabetic peripheral neuropathy patients with significant clinical efficacy, not only can improve serum IGF-1, IGFBP-1, BDNF, MBP levels, but also regulate the peripheral nerve conduction velocity and improve quality of life. 2018 Vol. 24 (7): 1104-1107 [Abstract] ( 78 ) HTML (1 KB)  PDF (1324 KB)  ( 186 ) 1108 Effect of Scapular Motion control Training combined with Cerebroprotein Hydrolysate for Injection Powder Injection on upper Limb Movement and Executive Function Impairment in Hemiplegic Patients with Cerebral Infarction LI Jing, QIN Da, YAN Hong, et al DOI: 10.3969/j.issn.1006-6233.2018.07.013 Objective: To study the effect of scapular motion control training combined with brain protein hydrolysate on motor and executive function impairment in patients with cerebral infarction. Methods: 90 patients of hemiplegia of cerebral infarction who received therapy from March 2015 to March 2016 in our hospital were selected as research objects. According to drawing methodthose were divided into the treatment group (n=45) and the control group (n=45). The two groups of patients were treated with routine treatment, including oxygen inhalation, dehydration, reducing craniofacial pressure, maintaining acid-base and water electrolyte balance, preventing infection and so on. The control group was treated with brain protein hydrolysate powder. While the treatment group on the basis of the control group, treated with exercise control of scapula. Then treatment efficacy, muscle strength, Fugl-Meyer (FMA) score, improvement of executive function impairment, neurological deficit score (NIHSS) and activity of daily living (ADL) of two groups were compared. Results: The total effective rate of the treatment group was significantly higher than that of the control group [91.11%(41/45)vs71.11%(32/45)](P<0.05); The score of muscle strength and FMA was significantly higher than that of the control group [(4.69±0.95)score vs (3.78±0.62)score, (60.37±6.08)score vs(72.90±4.73)score](P<0.05); The improvement of executive function score was greater than that of the control group(P<0.05); The NIHSS score was significantly lower than that of the control group[(7.36±2.30)score vs(11.50±3.10)score](P<0.05). The ADL score was significantly higher than that of the control group [(87.09±15.23)score vs(70.46±12.41)score](P<0.05). Conclusion: Omoplate motion control training combined with brain protein hydrolysate has the remarkable curative effect in the treatment of hemiplegia due to cerebral infarction, which can effectively improve the patient's motor function and executive function, restore nerve function, improve the quality of life of patients. 2018 Vol. 24 (7): 1108-1112 [Abstract] ( 72 ) HTML (1 KB)  PDF (1342 KB)  ( 147 ) 1113 Contrastive Analysis of Contrast-enhanced Ultrasound and Enhanced CT in Evaluating the Efficacy of TACE in the treatment of Primary Liver Cancer WANG Xi, LI Dong, HE Fen, et al DOI: 10.3969/j.issn.1006-6233.2018.07.014 Objective: To comparatively analyze the value of contrast-enhanced ultrasound and enhanced CT in evaluating the curative effect of transcatheter arterial chemoembolization (TACE) in the treatment of primary liver cancer. Methods: 70 patients with primary liver cancer treated by TACE in the hospital from January 2015 to December 2017 were selected as the subjects. All patients were examined by contrast-enhanced ultrasound, enhanced CT and digital subtraction angiography (DSA) at 1 month after operation. With DSA as the golden standard, the sensitivity, specificity and accuracy of contrast-enhanced ultrasound and enhanced CT in evaluating the curative effect of TACE were compared. Results: DSA showed 63 residual lesions (positive) and 31 negative lesions. With DSA as the golden standard, the sensitivity, specificity and accuracy of contrast-enhanced ultrasound in the diagnosis of residual lesions(positive) (95.24%,100.00%and 96.81%) were significantly higher than those of enhanced CT (84.13%,100.00%and 89.36%) (P<0.05). Conclusion: Compared with contrast-enhanced CT, the sensitivity and accuracy of contrast-enhanced ultrasound are significantly higher in diagnosing residual lesions after TACE for primary liver cancer. It is an effective method for evaluating the curative effect of TACE in the treatment of primary liver cancer. 2018 Vol. 24 (7): 1113-1116 [Abstract] ( 80 ) HTML (1 KB)  PDF (1687 KB)  ( 204 ) 1121 Relationship between Serum Adiponectin, Leptin and The Receptors Expression and Clinicopathological Parameters in Patients with Colorectal Cancer JIANG Yong, TAN Weilin, HAN Lu, et al DOI: 10.3969/j.issn.1006-6233.2018.07.016 Objective: To investigate the risk, development and metastasis of Adiponectin (ADPN), adiponectin receptor 2 (adipoR2), Leptin (LP) and leptin receptor (LEPR) in patients with colorectal cancer. Methods: 43 patients with colorectal cancer hospitalized in the proctology department of our hospital and confirmed by pathology (tumor type, cell morphology and invasion depth) were enrolled into case group, 31 healthy individuals were included into control group, the general clinical data of all the selected subjects were collected. The levels of ADPN and LP in serum were measured by ELISA, and the expression of adipoR2 and LEPR mRNA was detected by RT-PCR. Results: The BMI, FBG, TC, HDL-C, LDL-C and TG between the two groups had no significant difference (t=0.78, 0.23, 0.64, 0.93, 0.19, 0.99, P>0.05), the prevalence rate of colorectal cancer in patients with family history of colorectal cancer was higher than those patients without the family disease history, the differences were statistically significant (χ2=12.13, P<0.05); The ADPN levels and adipoR2 mRNA expression level in serum were lower than those in the control group, and the LP levels and LEPR mRNA expression level in serum were higher than those in the control group (t=2.53, 4.29, 4.75, 6.24, P<0.05); Compared with patients in stageⅠ, The ADPN levels and adipoR2 mRNA expression level in serum decreased with the increase of TNM staging in colorectal cancer, and the LP levels and LEPR mRNA expression level in serum increased with the increase of TNM staging in colorectal cancer (F=9.90, 3.52, 8.70, 9.21, P<0.05); The ADPN levels and adipoR2 mRNA expression level in serum were negatively correlated with TNM stage (r=-0.335, -0.341, -0.557, -0.492, -0.665, -0.757, -0.815, -0.753, P<0.05), while the LP levels and LEPR mRNA expression level were positively correlated with TNM stage (r=0.396, 0.516, 0.510, 0.641, 0.642, 0.628, 0.695, 0.682, P<0.05). Conclusion: ADPN levels and LP levels and their receptor expression can be used as a marker for the diagnosis of colorectal cancer. In colorectal cancer patients, the level of ADPN and its receptor expression are significantly decreased, and the level of LP and its receptor expression are increased significantly. 2018 Vol. 24 (7): 1121-1124 [Abstract] ( 80 ) HTML (1 KB)  PDF (1329 KB)  ( 184 ) 1125 The Diagnostic Value of Selective Salpingography and Fallopian Tube Recanalization in Treating female Infertility MIAO Jie, LIU Mingming, MENG Ying, et al DOI: 10.3969/j.issn.1006-6233.2018.07.017 Objective: To explore the value of selective hysteroslapingography (SSG) and fallopian tube recanalization (FTR) in diagnosing and treating fallopian tubal infertility. Methods: All the data of 150 cases of female infertility caused by oviduct were retrospective analyzed. The patients underwent selective salpingography and recanalization, followed up for one year, and the diagnostic value were evaluated. Results: Of the 281 fallopian tubes, there were 224 cases with different degrees of obstruction or unblocked success.196 cases were succeeded again after surgery, and the success rate was 87.5%.One-sided or two-sided recanalized (47 cases of spontaneous conception in one year), and the pregnancy rate was 37.9%. Conclusion: Selective salpingography and recanalization have important diagnostic significance for infertility caused by oviduct cause and have important reference value for assisted reproductive technology. 2018 Vol. 24 (7): 1125-1127 [Abstract] ( 70 ) HTML (1 KB)  PDF (1387 KB)  ( 135 ) 1128 Comparison of Clinical Efficacy and Prognosis between Vocal Cords Polyp assisted by Self-retaining Laryngoscope and Fiberolaryngoscope LI Xinlong, YANG Changguo DOI: 10.3969/j.issn.1006-6233.2018.07.018 Objective: To explore the difference in the clinical effect of support laryngoscope and fiber laryngoscope assisted resection for the patients with vocal cord polyps. Methods: Eighty-four cases of vocal cord polyps in our hospital from January 2016 to January 2017 were selected as the subjects. The patients were divided into two groups according to the random number table. The study group (n=42) underwent support laryngoscopy assisted resection and the control group (n=42) underwent fiber laryngoscopy assisted resection. The clinical efficacy of the two groups, acoustic acoustic parameters (basal frequency perturbation, standardized noise energy, amplitude perturbation), complications and recurrence rate of 12 months after operation were observed. Results: The total effective rate of the study group (95.24%) was higher than that of the control group (78.57%), and the total incidence of complications (4.76%) was lower than that of the control group (19.05%), the difference was statistically significant (χ2=5.126, 4.086, P<0.05). After treatment, two groups of acoustic parameters were improved compared with before treatment, the study group frequency perturbation, normalized noise energy and amplitude perturbation level respectively (0.18±0.04)% and (-14.23±2.08) DB, (1.66±0.54)%, lower than that of the control group (0.32±0.07)%, (-10.46±1.85)DB, (2.13±0.68)%, the difference was statistically significant (P<0.05). In the study group, the recurrence rate of 12 months after operation (2.38%) was lower than that of the control group (14.29%), and the difference was statistically significant (χ2=3.896, P<0.05). Conclusion: Compared with Fiber laryngoscope, support laryngoscope assisted removal of vocal cord polyp is more effective, which can significantly improve voice and acoustic parameters, reduce complications and recurrence rate. It is beneficial to the improvement of prognosis. 2018 Vol. 24 (7): 1128-1131 [Abstract] ( 67 ) HTML (1 KB)  PDF (1300 KB)  ( 179 ) 1132 Changes of Serum Transaminase Level in Patients with Blunt Abdominal Trauma and their Correlation with Liver Injury DING Gang DOI: 10.3969/j.issn.1006-6233.2018.07.019 Objective: To investigate the changes of serum liver transaminase levels in patients with closed abdominal trauma and its significance in liver injury. Methods: A total of 157 patients with closed abdominal trauma admitted to our hospital from August 2010 to August 2017 were selected as the study objects. The patients were divided into liver injury group (77 cases) and no liver injury group (80 cases) according to the presence or absence of liver injury.According to the grading standards established by the American College of Trauma Surgery (AAST), the liver injury group was divided into two groups: mild liver injury group (I-II grade, 32 cases), moderate grade group (III grade, 22 cases) Grade, 23 cases). According to the treatment, they were divided into operation group (32 cases) and conservative group (45 cases).The expression levels of alanine aminotransferase (alt), aspartate transaminase (AST) and γ -glutamyltransferase (GGT) were observed and compared. Results: the levels of ALT, AST and GGT in liver injury group were (274.15±33.19) U/L, (283.65±35.42) U/L, (46.24±6.07) U/L, which was higher than that in the group without liver injury (35.06±4.72) U/L, (58.96±7.21) U/L, (25.62±7.21) U/L, the difference was statistically significant (t= 63.773,55.562,25.595, P<0.05).The levels of ALT, AST and GGT in severe group were higher than those in mild group and mild group (P <0.05). The levels of ALT, AST and GGT in moderate group were higher than those in mild group (P <0.05).The levels of ALT, AST and GGT in the surgical treatment group were higher than those in the conservative treatment group, but the difference was not statistically significant (P> 0.05). Conclusion: The elevated level of serum liver transaminase in patients with closed abdominal trauma has high diagnostic value for liver injury and may indicate the severity of liver injury. 2018 Vol. 24 (7): 1132-1134 [Abstract] ( 56 ) HTML (1 KB)  PDF (1306 KB)  ( 196 ) 1135 The Relationship between Plasma NT-proBNP and the Prognosis on Location Myocardial Infarction CHEN Guancheng, CHEN Zhelin, FANG Tianyuan, et al DOI: 10.3969/j.issn.1006-6233.2018.07.020 Objective: To analyze the effect of amino-terminal pro-brain natriuretic peptide (NT-proBNP) on the disease site of myocardial infarction and prognosis. Methods: 120 patients with myocardial infarction received therapy from January 2017 to June 2017, plasma NT-proBNP levels were detected by enzyme-linked immunoassay. The relationship between the plasma NT-proBNP and the different sites, Gensini integrals, cardiovascular events and prognosis was analyzed. Results: Level of NT-proBNP in the anterior wall infarction group was higher than that of the anterior wall infarction group, the anterior wall infarction group and the lower wall infarction group, there was a statistical difference (P<0.05). NT-proBNP in severe group was higher than the moderate group and was higher than the mild group, with a statistically significant difference (P<0.05). The plasma NT-proBNP level in recurrent myocardial infarction, heart failure and cardiac death group was higher than that in the untreated group (P<0.05). Multivariate Logistic regression showed that the anterior wall infarction, Gensini integral and NT-proBNP were independent risk factors for the prognosis of myocardial infarction patients. The area under the ROC curve of the NT-proBNP level was 0.649 (95%cl was 0.508~0.790, P<0.001), the cutoff value was 0.162, and the sensitivity and specificity were 0.561 and 0.731. Conclusion: NT-proBNP can reflect the location of myocardial infarction, and can serve as an important biomarker for predicting the prognosis of patients. 2018 Vol. 24 (7): 1135-1138 [Abstract] ( 97 ) HTML (1 KB)  PDF (1727 KB)  ( 164 ) 1139 Effect of Thoracoscopic Segmentectomy on Early Stage Non-small Cell Lung Cancer and its Influence on Cardiopulmonary Function LI Chuanhai, MO Xiuxin, SUN Zhiyun, et al DOI: 10.3969/j.issn.1006-6233.2018.07.021 Objective: To observe the effect of thoracoscopic segmentectomy for the treatment of early stage non-small cell lung cancer and its influence on cardiopulmonary function and evaluate its clinical value. Methods: Retrospective analysis 62 cases of patients with early-stage non-small cell lung cancer treated in our hospital from June 2015 to September 2017, 31 patients who received thoracoscopic lobectomy were as the routine group, 31 patients who received thoracoscopic segmentectomy were as the research group. The peri-operative period, intraoperative lymph node dissection, cardiac and pulmonary function before and after operation, postoperative complications, recurrence and the 1 year survival rate were analyzed and compared between the two groups. Results: The operation time of the study group was longer than that of the conventional group (P<0.05). However, the amount of bleeding, wound drainage, hospitalization time and dosage of analgesics in the study group were all lower than those in the conventional group (P<0.05). There was no significant difference in the number of total lymph node dissection and mediastinal lymph node dissection between the two groups (P>0.05). However, the incidence of postoperative complications was less than that of the conventional group (P<0.05); The forced expiratory volume (FVC), forced expiratory volume (FEV1) and maximum ventilation (MVV) in two groups before surgery were not significantly different between the two groups (P>0.05), after operation, FVC, FEV1 and MVV in both groups were increased (P<0.05), and the levels of FVC, FEV1 and MVV in the postoperative operation group were higher than those in the conventional group (P<0.05); Preoperative heart rate (HR), stroke volume per minute (SV), left ventricular ejection fraction (LVEF) no difference (P>0.05), after operation, the HR of both groups decreased (P<0.05), and the levels of SV and LVEF increased (P<0.05),the HR of the study group after surgery was significantly lower than that of the conventional group (P<0.05), study group SV, LVE increased more than the conventional group (P<0.05); Both groups had different degrees of recurrence postoperatively, but no recurrence was found between the two groups (P>0.05). The 1-year survival rate of the study group was significantly higher than that of the study group (P <0.05). Conclusion: Thoracoscopic resection of the lung segment for the treatment of early non-small cell lung cancer curative effect is exact, can reduce intraoperative bleeding, shorten hospital stay, reduce pain and reduce postoperative analgesic dosage, can improve cardiorespiratory function, and 1-year survival rate Higher, it is worth clinical promotion. 2018 Vol. 24 (7): 1139-1143 [Abstract] ( 107 ) HTML (1 KB)  PDF (1348 KB)  ( 246 ) 1144 Clinical Efficacy of Extracorporeal Shock Wave Lithotripsy in the treatment of Lower Urinary Calculi and Analysis of the Factors Influencing the Complications LI Baijun, WU Lanfang, XIANG Hui, et al DOI: 10.3969/j.issn.1006-6233.2018.07.022 Objective: To study clinical efficacy of extracorporeal shock wave lithotripsy in the treatment of lower urinary calculi and analysis of the factors affecting the complications. Methods: A retrospective analysis of 900 cases of lower urinary calculi in our hospital from January 2000 to October 2017 in our hospital were selected as research objects, The number of operations, the time of net operation, the time of operation, the time of hospitalization, the curative effect, the complications and the influencing factors of complications were observed by Logistic regression analysis. Results: Of the 990 cases, 410 cases were excluded from 1 times of gravel, accounting for 45.55%; 273 cases of 2 lithotripsy cases, accounting for 30.33%; 161 cases of 3 lithotripsy cases, accounting for 17.88%. The operation time was 30~70min, the average (52.39 + 3.10) min. After 6 months of follow-up, 519 cases (57.66%) were cured, 325 cases were effective (36.11%), 56 cases were invalid (6.22%), and the total effective rate was 93.77% (844/900) (P<0.05); Among 900 patients, 658 cases had complications and 242 cases had no complications. There were significant differences between body weight index, stone length diameter, stone diameter, impact times and impact energy between the two groups (P<0.05); In the Logistic regression analysis of the influencing factors of postoperative complications of lower urinary calculi, stone length diameter, stone diameter, impact times and impact energy were all the complications after lower urinary calculi surgery (P<0.05). Conclusion: The clinical effect of extracorporeal shock wave lithotripsy in the treatment of lower urinary calculi is significant. The possible factors of postoperative complications are mainly the length of the stone, the diameter of the stone, the number of times of impact, the impact energy, the greater the number of shocks, the greater the probability of complications. In clinical application, the indications and operating procedures should be strictly controlled to avoid the occurrence of complications so as to achieve better clinical efficacy. 2018 Vol. 24 (7): 1144-1147 [Abstract] ( 97 ) HTML (1 KB)  PDF (1330 KB)  ( 228 ) 1148 Safety and Feasibility of Laparoscopic Common Bile Duct Suture for Patients with Choledocholithiasis with History of Biliary Tract Surgery after Endoscopic Drainage LI Defu DOI: 10.3969/j.issn.1006-6233.2018.07.023 Objective: To analyze the effect of primary suture of common bile duct in patients with choledocholithiasis with history of choledocholithiasis treated by laparoscopy after nasobiliary drainage. Methods: From February 2014 to February 2016, 62 cases of choledocholithiasis with history of choledocholithiasis treated by cholangiopancreatic surgery were divided into two groups: control group and observation. Group, 31 cases in each group. The control group and Eisou routine laparoscopic choledochus examination, T tube drainage, the observation group is under laparoscopic nasobiliary drainage. Laparoscopic choledochus primary suture was performed. Results: The white blood cells in the observation group were (12.86±1.86)×109L-1, which were significantly lower than those in the control group (13.95±1.86)×109L-1, P<0.05; The tube time was (5.21±0.28) d, which was significantly lower than that of the control group (32.07±0.54) d, P<0.05; The length of hospital stay was (9.71 ±1.51) d, which was significantly lower than that of the control group (19.32±4.54) d, P<0.05; The length of the operation was (187.86±13.79) min, which was lower than that of the control group (181.65±15.49) min, P>0.05; The total bilirubin was (37.04±13.72) mol/L, lower than that of the control group (45.79±32.94) mol/L, P>0.05. There was no significant difference in postoperative complications between the two groups (P>0.05). Conclusion: Choledocholithiasis with the history of choledocholithiasis with the history of choledochal surgery in the treatment of biliary tract surgery after naso biliary drainage is of good maneuverability and high safety. 2018 Vol. 24 (7): 1148-1151 [Abstract] ( 72 ) HTML (1 KB)  PDF (1327 KB)  ( 212 ) 1152 Clinical Application of Ultrasound Guided Percutaneous Dilational Tracheotomy in Establishment of Artificial Airway for Critically ill Patients PENG Chaohua, TANG Jin, YOU Yan DOI: 10.3969/j.issn.1006-6233.2018.07.024 Objective: To observe the clinical application effect of ultrasound guided percutaneous dilational tracheostomy (PDT) in establishment of artificial airway for critically ill patients. Methods: 90 critically ill patients in intensive care unit (ICU) from March 2016 to April 2017 were selected, and PDT was performed in establishment of artificial airway. They were randomly divided into 2 groups, 45 cases in each group. Group A was treated by ultrasound guided PDT, while group B was treated by fiber bronchoscope assisted PDT. The operative indexes, tracheal intubation, postoperative recovery indexes and incidence of complications were compared between the 2 groups. Results: The operative time, bleeding volume and air leakage rate of air bag in group A were shorter / less / lower than those in group B (P < 0.05). There was no significant difference between the 2 groups in the length of incision, the incidence of intraoperative hypoxemia, the success rate of initial intubation, the distance of tracheal intubation backing to the incisor, postoperative weaning time, extubation time, length of stay in ICU, total length of stay hospital or total incidence rate of postoperative complications (P > 0.05). Conclusion: Compared with fiber bronchoscope, ultrasound guided PDT in establishment of artificial airway can shorten the operative time and decrease the bleeding volume and air leakage rate of tracheal intubation during operation, and it has high safety and accuracy. 2018 Vol. 24 (7): 1152-1154 [Abstract] ( 97 ) HTML (1 KB)  PDF (1297 KB)  ( 317 ) 1155 Effective Comparing of three Types of Open Surgery in the treatment of L4/5 Intervertebral Disc Protrusion MA Shuwei, WU Jigong DOI: 10.3969/j.issn.1006-6233.2018.07.025 Objective: To evaluate the clinical and radiographic results of three surgical methods namely dynesys, discectomy, and spinal fusion and internal fixation in the treatment of lumbar degenerative disease. Memods:Among the 82 cases of lurnbar degenerative disease from July 2010 to July 2013, 26 patients were treated with Dynesys procedure (Group A), 32 with spinal fusion and internal fixation (Group B) and 24 with discectomy (Group C). The follow-up periods were made between 2 and 3 years, an average of 2.4 years. Clinical outcomes in term of range of motion(ROM), intervenebral height of lumbar segments and ROM of adjacent segment were evaluated by visual analogue scale (VAS) and 0swestry disability index (ODI). Results: Group C with discectomy was much less than the other two(P<0.05)in terms of operation time and amount of bleeding while Group A with Dynesys was lower than the Group treated with spinal fusion and internal fixation(P<0.05). All 3 groups at the last follow-up have seen significant improvements in VAS and ODI figures compared with the numbers before operation (P<0.05) and the disparity among them makes no difference statistically (p>0.05). The intervenebral heights of lumbar segments for the three had not shown any dramatic variation before surgery (p>0.05)while the figure of Group B with spinal fusion and internal fixation increased significantly and the one of Group C dropped at the last follow-up (P<0.05). At the last follow-up the ROM of Group C had barely changed significantly compared with preoperative period(p>0.05)while the spinal fusion and internal fixation group and the Dynesys group decreased remarkably(P<0.05). During the preoperative period, there were no marked disparity in ROM of adjacent segment among the three groups(p>0.05)while at the last follow-up Group B with spinal fusion and internal fixation and Group C with Dynesys have both increased compared with their preoperative figures(P<0.05)and the discectomy group has remained unchanged (p>0.05). Conclusions:The three methods can all produce good results. Considering operation time and amount of bleeding discectomy is better than the other two groups; spinal fusion and internal fixation and Dynesys are more preferred than discectomy in opening lesion segments; and discectomy and Dynesys can equally maintain the ROM of parts of lesion segments, but the latter can achieve a better balance between ROM and stability, preventing effectively further lesion segment degeneration. 2018 Vol. 24 (7): 1155-1160 [Abstract] ( 81 ) HTML (1 KB)  PDF (2787 KB)  ( 214 ) 1161 Clinical Application of L - shaped Extended Lateral Approach and Sinus Tarsi Approach Respectively Combined with Arthroscope Assisted reduction and Internal Fixation in Sanders II and III Calcaneal Fracture Surgery SHENG Wei, LIN Min DOI: 10.3969/j.issn.1006-6233.2018.07.026 Objective: To investigate and compare the effects of L-shaped extended lateral approach and sinus tarsi approach respectively combined with arthroscope assisted reduction and internal fixation in the treatment of Sanders II and III calcaneal fractures. Methods: The data of 76 patients with Sanders II and III calcaneal fractures who underwent arthroscope assisted reduction and internal fixation in the hospital during the period from August 2014 to August 2016 were analyzed retrospectively. Patients treated by L-shaped extended lateral approach were included in the incision group (31 cases) while patients treated by sinus tarsi approach were included in the minimally invasive group (45 cases). The situation of surgery and the incidence of complications in the two groups were statistically analyzed. Changes in radiographic parameters were compared between the two groups. The recovery of foot function was evaluated with the ankle and hindfoot function scores in the American Orthopedic Foot Andankle Society (AOFAS) at 6 months after surgery. Results: There was no significant difference between the two groups in the surgical time, fracture healing time and the excellent and good rate of foot function recovery (P > 0.05). The intraoperative blood loss and postoperative drainage volume of the minimally invasive group were less than those of the control group, the time of waiting for surgery, length of incision and incision healing time were shorter than those of the incision group (P < 0.05). The Bohler's angle, calcaneal height and width were increased while the Gissane angle and shift distance of subtalar joint surface were decreased in the two groups at the end of follow-up (P < 0.05), without statistically significant differences between the two groups (P > 0.05). The incidence rates of incision related complications and fetlock joint stiffness in the incision group were significantly higher than those in the minimally invasive group (P < 0.05). Conclusion: Effects of the two approaches combined with arthroscope assisted reduction and internal fixation are similar in the treatment of Sanders II and III calcaneal fractures. Compared with L - shaped extended lateral approach, sinus tarsi approach can reduce surgical trauma and further reduce the incidence of postoperative complications. 2018 Vol. 24 (7): 1161-1164 [Abstract] ( 78 ) HTML (1 KB)  PDF (1325 KB)  ( 128 ) 1165 Diagnostic Value of Non-enhanced MRI and Diffusion Weighted Imaging in Adult Prostate Cancer: a Meta analysis CHEN Song, ZHAO Mingzeng, YANG Ruwu, et al DOI: 10.3969/j.issn.1006-6233.2018.07.027 Objective: To evaluate the overall diagnostic value of non-enhanced MRI and DWI in adults with Prostate cancer. Methods: All the papers concerning the diagnosis of prostate cancer using non-enhanced MRI and DWI in both English and Chinese published had been searched and reviewed, and the studies with the surgery or pathology as the gold standard were adopted as eligible. According to the requirements of Meta analysis and the recognized quality standard of diagnostic test, we assessed whether all the included studies were eligible and extracted the characteristic information of the above studies.Stata14.0 software was used to test the heterogeneity of the above features. After that, MetaDisc1.4 software was used to calculate the total sensitivity and specificity. The diagnostic accuracy of the method was evaluated by Meta, and the receiver operating characteristic curve (SROC) was used to evaluate the accuracy of the method. Results: 16 articles were in accordance with the inclusion criteria. The pooled indexes of diagnostic performance and summary receiver operating characteristic curve (SROC) demonstrated a high discriminatory power for detection prostate cancer by non-enhanced MRI and DWI. In the pooled estimates, sensitivity and specificity were 59%(95% confidence interval 0.57 to 0.61) and 89 %(95% confidence interval 0.88 to 0.90) respectively, AUC was 0.879 . Conclusion: Non-enhanced MRI and DWI may be a highly accurate and non-invasion diagnostic tool for detecting prostate cancer in dults. 2018 Vol. 24 (7): 1165-1168 [Abstract] ( 91 ) HTML (1 KB)  PDF (1762 KB)  ( 182 ) 1169 The Clinical Status of Hip Ankylosis after Internal Fixation for Hip Fracture and the Second Selection of Retreatment Plan YANG Yi, WEN Junen, ZHAO Hai, et al DOI: 10.3969/j.issn.1006-6233.2018.07.028 Objective: To research the clinical status of hip ankylosis after internal fixation for hip fracture and the selection of retreatment plan. Methods: The medical records of 82 elderly patients with hip ankylosis after fracture fixation were analyzed retrospectively. According to the different treatment plan, they were divided into the hip replacement group (50 cases) and the re internal fixation group (32 cases). Analyzed the causes of postoperative ankylosis and the choice of retreatment regimen, and compared the clinical efficacy and prognosis of the two retreatment regimens. Result: The main causes of ankylosis after internal fixation were screw loosening, head and neck cutting, poor fracture healing or osteonecrosis of the femoral head. In the choice of re treatment plans, most patients were selected partial fracture healed again. The patients with nonunion or necrosis of the femoral head were all selected for total hip replacement. There were no significant differences in the hip function score and barthel score at each time point after treatment in two differcet re treatment plans, and the differences were not statistically significant, the differences were not statistically significant (P>0.05). During the follow-up period, there were no complications such as deep vein thrombosis, infection, loosening and subsidence of the prosthesis, and the two treatments were safe and reliable. Conclusion: Artificial total hip replacement or secondary internal fixation can help patients to promote fracture healing, eliminate joint stiffness, so as to restore hip function as soon as possible. The appropriate treatment should be selected according to the actual situation of the patients. 2018 Vol. 24 (7): 1169-1173 [Abstract] ( 98 ) HTML (1 KB)  PDF (2075 KB)  ( 218 ) 1174 Curative Efficacy of Gemcitabine combined with Nida Platinum in treatment of Patients with Advanced Non-small Cell Lung Cancer and the Effects of Serum Tumor Markers XU Yang, CHEN Dan, LI Fanmin DOI: 10.3969/j.issn.1006-6233.2018.07.029 Objective: To study curative efficacy of gemcitabine combined with nida platinum in treatment of patients with advanced non-small cell lung cancer and its effects on the effect of serum tumor markers. Methods: 150 patients of late nonsmall cell lung who received therapy from July 2016 to December 2017 were selected as research objects. 75 cases were randomly divided into observation group and 75 in control group. The observation group was treated with gemcitabine combined with nidaliplatin. The control group was treated with cisplatin. The clinical efficacy and quality of life of the two groups were compared. Two groups of patients were recorded before and after treatment of cancer embryo antigen (CEA), carbohydrate antigen 125 (CA125), cytokeratin fragment antigen 21-1 (CYFRA21-1), and neuron specific enolase (NSE). The adverse reactions of the two groups were recorded. The survival time of the two groups was recorded. Results: After treatment, the effective rate was 54.67%, significantly higher than 33.33% in the control group, and the difference was statistically significant (P<0.05). Before treatment, there was no significant difference in the indexes of the two groups. After treatment, both groups showed a decrease in each index level, which was statistically significant (P<0.05). Observation group CEA, CA125 and cyfra21-1 were both lower than the control group, and the difference was statistically significant (P<0.05). After treatment, there was no significant difference in NSE level between the two groups (P>0.05). After treatment, there was no statistically significant difference between the two groups. The ECOG score of observation group was significantly higher than that in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the difference between the two groups in the survival period, and the observation group was significantly higher than the control group with no progress in survival and median survival, and the difference was statistically significant (P<0.05). The incidence of hair loss, nausea and vomiting in the observation group was significantly lower than that in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of thrombocytopenia, leukocyte decline, hemoglobin reduction, hepatotoxicity, phlebitis and constipation in both groups (P>0.05). Conclusion: The treatment of patients with advanced non-small cell lung cancer treated by gemcitabine combined with nidaplatin is more effective, with less adverse reactions, and the patient can tolerate the disease, and it is worth promoting the application. 2018 Vol. 24 (7): 1174-1177 [Abstract] ( 137 ) HTML (1 KB)  PDF (1316 KB)  ( 141 ) 1178 Risk Factors of Hypertensive Disorders of Pregnancy and the Effectsof Target Organ Damage YIN Xue, et al DOI: 10.3969/j.issn.1006-6233.2018.07.030 Objective: To investigate the risk factors of hypertensive disorders of pregnancy (HDP) and the association between gestational hypertension and target organ damage. Methods: From Oct 2015 to Oct 2017, 1468 pregnancy women were enrolled in Xintai People's Hospital. Clinical data, such as age, pre-pregnancy body mass index(BMI), blood pressure and family history of HDP were collected. Left ventricular hypertrophy was assessed by left ventricular mass index (LVMI) using cardiac color Doppler ultrasound. Estimate glomerular filtration rate (eGFR) was calculated base on the level of serum creatinine. Their clinical data were analyzed and logistic regression model was made to determine risk factors of HDP. Multivariate linear regression analysis was made to determine the independent influencing factors of LVMI and eGFR. Results: The prevalence of HDP was 5.18% among 1468 pregnancy women. Age (OR=3.071, 95%CI: 1.583-5.957), pre-pregnancy BMI (OR=1.213, 95%CI: 1.064-1.382), pre-pregnancy anxiety (OR=1.684, 95%CI: 1.164-2.435) and family history of HDP (OR=2.678, 95%CI: 1.446-4.957) were independent risk factors of HDP (P<0.05). Twenty-four-hour systolic blood pressure and diastolic blood pressure were positively correlated with LVMI (correlation coefficients were 0.736 and 0.702, respectively, all P<0.001) and negatively correlated with eGFR (correlation coefficients were -0.696 and -0.633, respectively, all P<0.001). After adjustment for confunders, 24-hour systolic blood pressure and diastolic blood pressure were independently and significantly associated with LVMI and eGFR (all P<0.05). Conclusion: Advanced age, pre-pregnancy BMI, pre-pregnancy anxiety and family history of HDP were independent risk factors of HDP. However, HDP played a crucial and independent role of target organ damage. 2018 Vol. 24 (7): 1178-1182 [Abstract] ( 100 ) HTML (1 KB)  PDF (1340 KB)  ( 162 ) 1183 Clinical Study of Serum 25-hydroxyvitamin D level and Inflammatory Factors and Nutritional Status in Continuous Ambulatory Peritoneal Dialysis Patients LI Xuena, HU Guicai DOI: 10.3969/j.issn.1006-6233.2018.07.031 Objective: To evaluate the association between 25-hydroxyvitamin D level and inflammatory and nutritional factors in continuous ambulatory peritoneal dialysis. Methods: Serum levels of 25-hydroxyvitamin D, albumin, prealbumin, neutrophi-lymphocyte ratio(NLR),high-sensitivity-reactive protein (Hs-CRP),IL-6,and TNF-a were measured in 89 patients with continuous peritoneal dialysis.All the patients were divided into there groups according to the serum 25-hydroxyvitamin D level. Vitamin D normal: 25(OH)D＞30ng/ml,Vitamin D insufficiency: 16<25(OH)D≤30ng/ml,Vitamin D deficiency: 25(OH)D≤15ng/ml,Inflammatory factory and nutritive index were compared among the three groups. Result: The average of serum 25 (OH) D level was 5.0~41.2ng/ml in patients with continuous peritoneal dialysis, the prevalence of 25 (OH) D deficiency was 86.51%. The levels of Hs-CRP, IL-6, TNF-a, and NLR were obviously lower in 25 (OH) D normal group than deficiency and insufficiency group, albumin and prealbumin were higher than patients with vitamin D deficiency and insufficiency groups.the difference was statistically significant(P<0.001). Conclusion: The level of blood 25 (OH) D in continuous ambulatory peritoneal dialysis patients plays an important role in micro inflammatory state and malnutrition. 2018 Vol. 24 (7): 1183-1186 [Abstract] ( 59 ) HTML (1 KB)  PDF (1322 KB)  ( 139 ) 1187 The Experimental Study on the Inhibitory Effect of TBO-PDT on Biofilm of Oral Mixed Bacteria in Rats TAO Yadong, et al DOI: 10.3969/j.issn.1006-6233.2018.07.032 Objective: To Study the inhibitory effect of TBO-PDT in different photosensitizer concentration and different lighting time on the cariogenic bacteria in dental plaque biofilms of rats, and determine the optimal photosensitizer parameters and time parameters. On the basis of this, to discuss the advantages of TBO-PDT in inhibiting the biofilm of mixed bacterial plaque, and provided theoretical and experimental evidence for the application of PDT in the prevention of dental caries and to provid theoretical and experimental basis for the application of PDT for dental caries prevention. Method: The caries model was constructed with Wistar rats. All the rats in accordance with the principle of randomization were divided into groups as follows:Group A :a saline - negative treatment group;Group B:a positive control group for chlorhexidine. The other groups were based on the concentration of the photosensitizer as group C1:60mg/L, group D1:80mg/L, group E1:100mg/L, group F1:120mg/L, group G1:140mg/L. Treated group C1-G1 with incubation for 5 minutes in dark place and exposed 9min by a semiconductor laser with a wavelength of 630nm. The output strength was 105 mW/cm2. The rest groups were based on the exposure time:group C2:3min; group D2:6min; group E2:9min; group F2:12min; group G2:15min. Treated group C2-G2 with incubation for 5 minutes in dark place and exposed by a semiconductor laser with a wavelength of 532nm. The photosensitizer concentration was 100mg/L. The output strength was 105mW/cm2. According to the different exposure time, it was divided into C2 group 3min, D2 group 6min, E2 group 9min, F2 group 12min, G2 group 15min, and the photosensitizer concentration was 100mg/L after incubating 5min, and the output intensity was 105 diode laser. The inhibitory effect of TBO-PDT on oral mixed bacteria biofilm of rat oral mixed bacteria was evaluated by atomic absorption spectrophotometer, and the inhibitory effect of TBO-PDT on oral mixed bacterial plaque biofilm was evaluated by atomic absorption spectrophotometer. Resultes: The bacteriostatic effect of TBO-PDT on bacterial plaque in rat oral cavity was studied in different concentration of photosensitizer. The tablet colony count results showed with the increase of concentration of photosensitizer stress the bacteria inhibitive rate was increased. Compared to the negative control group and positive control group, bacteria inhibitive rate of group C1, group D1, group E1, group F1 and group G1 changed most obviously. Bacteria inhibitive rate of group E1, group F1 and group G1 were increased than positive control group. The bacteriostatic effect of TBO-PDT on bacterial plaque in rat oral cavity was studied in different exposure time. The tablet colony count results showed with the increase of exposure time the bacteria inhibitive rate was increased. Compared to the negative control group, bacteria inhibitive rate of group C2, group D2, group E2, group F2 and group G2 changed most obviously. Bacteria inhibitive rate of group E2, group F2 and group G2 were increased than positive control group. Results of the calcium ion dissolution detected by atomic absorption spectrophotometer showed with the increase of exposure time the calcium ion dissolution was increased in each group in 48 hours. Compared to the negative control group, the calcium ion dissolution of each group was decreased significantly (P<0.05). Compared to the negative control group, the calcium ion dissolution of each group was decreased. However, there was no significant difference between them (P>0. 05). Conclusion: TBO-PDT has obvious inhibitory effect on the biofilm of mixed bacteria plaque in rats. The results showed that the best photosensitizer concentration of TBO-PDT was 100 g/mL and the best illumination time was 9min. Photodynamic therapy can effectively inhibit the cariogenic bacteria in the bacterial plaque biofilm of rats, reduce the amount of calcium ion dissolution in early caries, not only prevent the continued demineralization of the enamel, but also promote the remineralization of the enamel. PDT has broad clinical application prospects in the prevention of dental caries. 2018 Vol. 24 (7): 1187-1193 [Abstract] ( 69 ) HTML (1 KB)  PDF (1895 KB)  ( 218 ) 1194 Clinical Anatomic Study of Atlas Pedicle Screw Placement WANG Jianhua, FU Jinli, et al DOI: 10.3969/j.issn.1006-6233.2018.07.033 Objective: To explore the direction of pedicle screw placement for atlas pedicle screw placement through anatomic measurement of atlas specimens and provide theoretical guidance for accurate placement of atlas pedicle screws. Methods: 20 healthy complete atlas specimens were anatomically measured, accurate nail entry points were selected, a constant nail reference system was found, and the angle relationship between the screw channel and the selected reference system was measured to determine the related parameters of the pedicle screw point and angle of the atlas. Results: the width and the height of posterior arch at the thinnest part of the vertebral artery groove; the distance from entrance point of screw to median plane S1=(21.2±3.5)mm; the whole length screw path AB=(26.1±4.4)mm;the distance between the internal and external margin of dorsal of below lateral mass of atlas S2=(11.1±1.1)mm (5) atlas horizontal angle (X) are(10.9±5.2)°; vertical angle (Y) were(4.1±0.7)°. Conclusion: The distance from the midpoint of the internal and external margins of the lateral mass of the atlas to the posterior arch is from the vertical distance from the bottom of the vertebral arch to the most thin part of the arch. 2mm is the insertion point of the screw. The lateral angle is 6 to 16 degrees, and the longitudinal angle is 3 to 5 degrees. It is safe, objective and reliable to select screws with a diameter of 3.5mm and 21.7mm to 30.5mm. 2018 Vol. 24 (7): 1194-1196 [Abstract] ( 87 ) HTML (1 KB)  PDF (1964 KB)  ( 239 ) 1197 Video Nystagmus Typing of Benign Paroxysmal Positional Vertigo and its Clinical Effect on Manipulative Reduction ZHANG Chengxiang DOI: 10.3969/j.issn.1006-6233.2018.07.034 Objective: To observe the therapeutic effect of the method of clinical application on benign paroxysmal positional vertigo ( BPPV ) . Methods: A total of 154 suspected BPPV patients treated in our hospital from August 2016 to August 2017 were selected as the main study subjects. According to the characteristics of nystagmus induced by video-ocystagmus transposition experiment, BPPV was used to determine the side and type. According to the results of typing, the appropriate manual reduction was selected. The posterior semicircular canal (PC-BPPV) was treated by Eply manual reduction and the upper semicircular canal (SC-BPPV) by semont manual reduction. Horizontal Regulation (HC-BPPV) was reset by Barbecue tumbling and mixed BPPV (C-BPPV) by Eply and 3 - month follow-up. Results: Of the 154 BPPV patients, 106 PC-BPPV (68.83%) were detected; 27 cases of HC - BPPV were detected; 14 cases of SC - BPPV ( 9.09 % ) were detected; 7 cases of C - BPPV ( 4.55 % ) were detected; and the total effective rates were 85.71 % and 93.51 % after 1 week and 3 months after operation. Conclusions: The video nystagmus can effectively classify the BPPV side. Under the surveillance, the manipulative reduction can effectively control the reset technique and improve the therapeutic effect of the clinical manipulation to the BPPV, and the recurrence rate is low after the operation, which has the clinical value. 2018 Vol. 24 (7): 1197-1200 [Abstract] ( 58 ) HTML (1 KB)  PDF (1322 KB)  ( 153 ) 1201 Cost Effectiveness and Safety Evaluation of two Regimens for Insomnia LI Xiurong, YU Nan DOI: 10.3969/j.issn.1006-6233.2018.07.035 Objective: To evaluate the pharmacoeconomic efficacy of two kinds of regimens used in outpatient department of our hospital for the treatment of insomnia, and to provide an objective basis for the rational use of insomnia in treating patients with insomnia. Methods: According to guidelines for the diagnosis and treatment of adult insomnia in China, the patients were randomly divided into two groups, a group of treatment group with Zolpidem Tartrate tablets 10mg/d, and a group of control group with Alprazolam 0.4mg/d. After seven-days administration before going to sleep, efficacy evaluation and the rate of adverse effect of the use of SDRS score were compared. And the cost effectiveness was analyzed. Results: The effective rate of the two groups respective were 77.78%,73.81%;The effective rate had no significant difference between two groups(P＞0.05); Adverse drug reaction had no significant difference between two groups(P＞0.05);The average cost in the Zolpidem Tartrate tablets group was 23.9 yuan, and the Alprazolam group was 0.63 yuan. Sensitivity analysis revealed that the results were not sensitive to changes in the drug cost. Conclusion: Both Zolpidem Tartrate tablets and Alprazolam tablets are available for insomnia, but more advantage of Alprazolam tablets in the cost-effectiveness. 2018 Vol. 24 (7): 1201-1203 [Abstract] ( 85 ) HTML (1 KB)  PDF (1303 KB)  ( 158 ) 1207 Clinical Study of Endoscopic Sinus Surgery combined with Medicine in the Treatment of Chronic Rhinosinusitis Complicated with Bronchial Asthma ZHONG Limei, BIAN Ka DOI: 10.3969/j.issn.1006-6233.2018.07.037 Objective: To investigate the efficacy of endoscopic sinus surgery (ESS) combined with medication in the treatment of chronic rhinosinusitis (CRS) complicated with bronchial asthma. Methods: The clinical data of 55 CRS patients with bronchial asthma from Oct.2014 to Oct.2016 were analyzed retrospectively, and all of them were treated with ESS, inhaled corticosteroids, nasal sprays, and anti allergy drugs. The effect of the comprehensive treatment on the acute attack of bronchial asthma during operation and the short-term curative effect of CRS and bronchial asthma were studied. Results: ①The perioperative period: 52 cases were in perioperative stable condition, whereas 3 cases were diagnosed as acute bronchial asthma. ②CRS effective follow-up: the postoperative visual analogue scale (VAS) score and endoscopic Lund-Mackay score of postoperative 12w and 48w were significantly lower than those of preoperative 1w (P<0.05), and the postoperative 48W was significantly lower than that of 12W (P<0.05). ③Bronchial asthma effective follow-up: The asthma control scale (ACT) scores of postoperative 12w and 48w were significantly lower than those of preoperative 1w (P<0.05), and there were no significant change in lung function before and after the operation (P>0.05). ④Drugs for bronchial asthma: 42 patients (76.4%) were treated with minimum dose of hormone for more than 24 weeks and discontinued after operation. Conclusion: The combination of standard ESS and drug therapy can effectively reduce the risk of perioperative asthma attack, improve CRS nasal symptoms, and have a positive effect on the recent asthma. 2018 Vol. 24 (7): 1207-1209 [Abstract] ( 77 ) HTML (1 KB)  PDF (1307 KB)  ( 136 ) 1210 Efficacy Observation of Budesonide Nasal Spray Combined with Montelukast Sodium in the Treatment of Allergic Rhinitis ZHAN Fei, CHEN Feng DOI: 10.3969/j.issn.1006-6233.2018.07.038 Objective: To investigate the efficacy of budesonide nasal spray combined with montelukast sodium in the treatment of allergic rhinitis. Methods: 90 patients with allergic rhinitis admitted in our hospital from September 2013 to May 2015 were randomly divided into two groups (45 in each group). Patients in group A received budesonide plus loratadine , Group B patients given budesonide + montelukast sodium, clinical symptoms score and treatment effect of two groups were compared. Results: The nasal obstruction score (0.81 ± 0.18), nasal itching score (0.61 ± 0.19), sneezing score (0.57 ± 0.15), and nasal discharge score (0.34 ± 0.13) in group A were significantly higher than those in group B (0.56 ± 0.15, 0.46 ± 0.11,0.41 ± 0.12,0.21 ± 0.08), there was significant difference (t = 12.451,9.261,7.051,5.337), with statistical significance (P <0.01); The total effective rate in group A (75.56% ) Was significantly lower than that in group B (93.33%), there was a significant difference (χ2 = 5.414), with statistical significance (P <0.05). Conclusion: Comparing the efficacy of budesonide plus loratadine, budesonide + montelukast sodium is the most effective treatment for allergic rhinitis. 2018 Vol. 24 (7): 1210-1212 [Abstract] ( 83 ) HTML (1 KB)  PDF (1306 KB)  ( 172 ) 1219 Effects of Ethacridine combined with Dinoprofen in treatment of Maternal Cervix and its Influcences on Bishop score, PGE2α, ET-1 level and Pregnancy outcome MENG Qingtang, YE Qing, WU Xiujuan DOI: 10.3969/j.issn.1006-6233.2018.07.041 Objective: To study the effects of ethacridine combined with dinoprofenone in treatment of maternal cervix and its effects on Bishop score, PGE2α, ET-1 level and pregnancy outcome. Methods: From April 2015 to March 2016, 86 pregnant women admitted in our hospital, randomly divided into observation group and control group, 43 cases per group. The control group was treated with dinoprofen, and the observation group was treated ethacridine on the basis of control group. The two groups of patients with cervical ripening, Bishop score, PGE2α, ET-1 levels, induction of labor were compared. Results: After treatment, the cervical Bishop score of the observation group was significantly higher than that of the control group(9.21±0.96 vs5.98±0.62 P<0.05), and the cervical ripening within 3 days was significantly better than that of the control group [93.02%(40/43) vs 72.09%(31/43)P<0.05]. The levels of PGE2α and ET-1 in the observation group were significantly higher than those in the control group [(8.78±0.82 vs 6.97±0.68 P<0.05), (3.26±0.38 vs 2.96±0.29 P<0.05)]. The rate of fetal distress and breaking rate in the observation group was significantly lower than that in the control group [4.65%(2/43)vs 25.58% (11/43)、6.98%(3/43)vs 27.91%(12/43)](P<0.05). There was no significant difference in the adverse reaction rate between the observation group and the control group [2.32%(1/43)vs 4.65%(2/43)](P>0.05). Conclusion: Ethacridine combined with dinoprofen can effectively promote maternal cervical maturation and improve the level of PGE2α and ET-1, which can effectively improve the outcome of pregnancy. 2018 Vol. 24 (7): 1219-1222 [Abstract] ( 108 ) HTML (1 KB)  PDF (1325 KB)  ( 201 ) 1223 The Study Correlation between Liver Stiffness and Pathological Staging of Liver Biopsy in Patients with Chronic Hepatitis B by Fibroscan CAO Faming, ZHANG Zhaoru, WANG Xiang DOI: 10.3969/j.issn.1006-6233.2018.07.042 Objective: To observe the correlation between liver stiffness measured by transient elastography (Fibroscan) and liver biopsy pathological stage of patients with chronic hepatitis B. Methods: 196 cases of patients with chronic hepatitis B who were admitted to the hospital from January 2016 to January 2018 were selected as the subjects. All patients underwent liver biopsy to determine the stage of liver fibrosis, and Fibroscan was used for liver stiffness measurement (LSM). The correlation of LSM with liver fibrosis was analyzed. Results: The sensitivity, specificity, accuracy and Kappa value of Fibroscan in detecting LSM stage S0 were 92.31% (12/13), 100.00% (183/183), 99.49% (195/196) and 0.96, respectively. For S1, the sensitivity, specificity, accuracy and Kappa value were 100.00%(54/54), 97.18%(138/142), 97.96%(192/196)and 0.95, respectively. Those for S2 were 97.18%(69/71), 99.20%(124/125), 98.47%(193/196)and 0.97, respectively, for S3 were 93.33% (42/45), 100.00% (151/151), 98.47% (193/196) and 0.96, respectively, and for S4 were 92.31%(12/13), 98.91%(181/183), 98.48%(193/196)and 0.88, respectively. Levels of ALT, AST, Knodell score and LSM were significantly lower in the mild fibrosis group than in the moderate and severe fibrosis group (P < 0.05). The LSM measured by Fibroscan was an independent risk factor for liver biopsy pathological stage (P < 0.05), and it was positively correlated with Knodell score and liver biopsy pathological stage (P < 0.05). Conclusion: Fibroscan can be used as a reference for evaluating the stage of liver fibrosis. Instead of partial liver biopsy, it is of great value for early diagnosis of liver cirrhosis. 2018 Vol. 24 (7): 1223-1225 [Abstract] ( 77 ) HTML (1 KB)  PDF (1310 KB)  ( 246 ) 1226 Risk Factors Analysis of 188 Cases of Young and Middle-aged Patients with Gastric Cancer in Chengde Area HAO Xin, WANG Rongsheng, SU Bin, et al DOI: 10.3969/j.issn.1006-6233.2018.07.043 Objective: To explore the influencing factors of gastric cancer in chengde area and provide the basis for scientific and effective preventive measures. Methods: 188 young and middle-aged gastric cancer patients admitted by chengde central hospital from November 2015 to November 2017 were selected as the study subjects.Demographic characteristics, dietary habits, family history, behavioral lifestyle, previous disease history, Hp infection and psychological factors were obtained by questionnaire.Univariate analysis and multivariate analysis of conditional logistic regression were used to screen the influencing factors of gastric cancer.Results: Eating fried barbecue food, eating pickled food, drink, chronic gastritis, gastric ulcer history, immediate family history of gastric cancer, Hp infection and depressed (OR were 3.574, 4.135, 10.632, 7.214, 13.245, 9.420, 5.341) is the independent risk factors of gastric cancer of the chengde area residents.Conclusion: Eating less fried or barbecue food, eating less pickled food, drinking less, early treatment of chronic stomach diseases such as chronic gastritis and gastric ulcer, effectively inhibiting the occurrence of Hp infection, maintaining the mood and pleasure can help prevent gastric cancer. 2018 Vol. 24 (7): 1226-1229 [Abstract] ( 90 ) HTML (1 KB)  PDF (1309 KB)  ( 232 )

Copyright © Editorial Board of HeBei Med Supported by:Beijing Magtech