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2019 Vol. 25, No. 7 Published: 2019-07-31 1057 Screening Differentially Expressed Proteins in Serum of Patients with Contrast-induced Acute Kidney Injury by Proteomics Technology GONG Yu, DING Feng, YANG Yan, et al DOI: 10.3969/j.issn.1006-6233.2019.07.001 Objective: To screen the differentially expressed proteins in the serum of patients with contrast-induced acute kidney injury (CI-AKI) after percutaneous coronary intervention (PCI) by proteomics technology. Methods: Serum samples were collected from 2 groups of patients: patients with AKI after PCI (CI-AKI patients group, n=10);patients without AKI after PCI (non-CI-AKI patients group, n=10). In order to study the dynamic alteration of serum proteome and screen for differentially expressed proteins in the course of disease progression, serum samples were collected from the two groups before exposure of contrast media (0 h) and 24 h and 48 h after the use of contrast media. Two-dimensional gel electrophoresis (2-DE), matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) and bioinformatics analysis were performed. Results: In the CI-AKI patients group, serum proteome of patients with CI-AKI changed significantly after PCI. Apolipoprotein E was identified as the continuously differentially expressed protein (3-fold up-regulated) in the serum from 0 h to 24h and 0 h to 48 h after PCI. Conclusion: The expression profiles of serum proteins in CI-AKI patients changed significantly after PCI. Apolipoprotein E protein was continuously 3-fold up-regulated during the pathological process of CI-AKI, which may become a candidate serum protein marker with diagnostic value for CI-AKI. 2019 Vol. 25 (7): 1057-1061 [Abstract] ( 157 ) HTML (1 KB)  PDF (1492 KB)  ( 283 ) 1062 Study on the Relationship between Medial Temporal Lobe Changes and Amnestic Mild Cognitive Impairment Based on VBM-DARTEL and FreeSurfer HE Pan, MA Qiang DOI: 10.3969/j.issn.1006-6233.2019.07.002 Objective: To investigate the correlation between amnestic-type mild cognitive impairment(aMCI) and the changes in ROI of medial temporal lobe by voxel-based morphological (VBM-DARTEL) and Freesurfer. Methods: 3D-T1WI image data of aMCI group, AD group and NC group were collected. Gray matter density of hippocampus, amygdala, endoolfactory cortex and papillary body was measured quantitatively by VBM-DARTEL algorithm. The volume of hippocampus and amygdala subarea was segmented and calculated by Freesurfer software. ANOVA test and multiple comparisons were made among the three groups. Results: The gray values of ROI were different in AD-MCI-NC, AD-MCI and AD-NC groups except for the nipple in vitro. There was no difference among the four ROI groups in MCI-NC. There was no significant difference in AD, MCI, NC and multiple comparisons between the anterior and inferior hippocampal brackets. The left amygdala basal nucleus, lateral nucleus, cortical amygdala transitional area, paraaminic nucleus and bilateral hippocampal amygdala transitional area were only significant differences in differentiating early AD from normal adults. Conclusion: VBM and Freesurfer can objectively and accurately reflect the slight changes of the medial temporal lobe of amnestic mild cognitive impairment and early AD, and can significantly distinguish amnestic mild cognitive impairment from early AD and early AD from normal adults, but have low sensitivity to distinguish amnestic mild cognitive impairment from normal adults. 2019 Vol. 25 (7): 1062-1068 [Abstract] ( 286 ) HTML (1 KB)  PDF (1328 KB)  ( 584 ) 1069 Efficacy of Shensong Yangxin Capsule on Ventricular Arrhythmia and its Effects on Serum β1-AAB Level ZHANG Jing, LI Jun, TANG Sanhua DOI: 10.3969/j.issn.1006-6233.2019.07.003 Objective: To study the efficacy of Shensong Yangxin capsule on ventricular arrhythmia (VA) and its effects on serum anti-β1-adrenoceptor autoantibody (β1-AAB) level. Methods: 146 patients with VA in our hospital from January 2017 to December 2018 were selected and divided into two groups according to the random number table method, with 73 cases in each group. The two groups were treated with amiodarone, and observation group was additionally given Shensong Yangxin capsule on this basis, and they were treated for 2 months. The clinical efficacy, and electrocardiograph (ECG) indicators, serum β1-AAB, T lymphocyte subsets and occurrence of adverse reactions after treatment were compared between the two groups. Results: The effective rates of treatment were 94.52% and 83.56% in observation group and control group(P<0.05). After treatment, there were no significant changes in PR interval and QT interval between the two groups (P>0.05), and the QTcd, β1-AAB, CD4+ and CD4+/CD8+ in the two groups were significantly decreased (P<0.05) while the CD8+ was significantly increased in the two groups (P<0.05), and the change of PR interval before and after treatment in observation group was smaller than that in control group, and the changes of QT interval, QTcd, β1-AAB, CD4+ and CD4+/CD8+ before and after treatment were greater than those in control group (P<0.05). The incidence rates of adverse reactions in the two groups were 13.70% and 9.59% respectively (P>0.05). Conclusion: Shensong Yangxin capsule combined with amiodarone can shorten the cardioversion time and reduce the QTcd value, and it is also beneficial to reduce the level of serum β1-AAB and improve the distribution of T lymphocyte subsets, thus improving the treatment effects. 2019 Vol. 25 (7): 1069-1072 [Abstract] ( 131 ) HTML (1 KB)  PDF (1266 KB)  ( 174 ) 1073 Effects of Calcitriol combined with Cinacalcet on Serum Calcium Phosphorus iPTH Osteoporosis and Cardiac Valve Calcification in Patients with Secondary Hyperparathyroidism WANG Yi DOI: 10.3969/j.issn.1006-6233.2019.07.004 Objective: To analyze the effects of calcitriol combined with cinacalcet on serum calcium, phosphorus, intact parathyroid hormone(iPTH), osteoporosis and cardiac valve calcification in patients with secondary hyperparathyroidism. Methods: The clinical data of 60 patients with secondary hyperparathyroidism who underwent maintenance hemodialysis were collected as a retrospective study. According to the different treatment methods, they were divided into group A (12 cases), group B (30 cases), and group C (18 cases). The differences of iPTH, blood calcium, blood phosphorus, heart valve calcification and osteoporosis were compared between the two groups before and after treatment. Results: After treatment, the serum calcium concentration in group A decreased significantly (P<0.05), while that in group B increased significantly (P<0.05), while that in group C did not change significantly (P>0.05); compared with before treatment, the serum phosphorus concentration in group A and C decreased significantly (P<0.05), while that in group B did not change significantly (P>0.05); and compared with before treatment, the concentration of iPTH in group A, B and C decreased significantly after treatment. After treatment, the level in group C was significantly better than that in other two groups (P<0.05). Compared with before treatment, there was no significant change in the degree of cardiac valve calcification in group A and B after treatment (P>0.05), while the degree of cardiac valve calcification in group C was significantly reduced after treatment (P<0.05). After treatment, the incidence of osteoporosis in group A and B was not significantly different from that before treatment (P>0.05); compared with before treatment, the incidence of osteoporosis in group C was significantly lower after treatment (P<0.05). Conclusion: Calcitriol combined with cinacalcet can promote the maintenance of serum calcium and phosphorus concentration in normal range and control the level of iPTH in secondary hyperparathyroidism patients. It can also effectively reduce the degree of cardiac valve calcification and the occurrence of osteoporosis. The therapeutic effect of the combined use of calcitriol and cinacalcet is better than that of single usage, so it is worthy of clinical application. 2019 Vol. 25 (7): 1073-1077 [Abstract] ( 160 ) HTML (1 KB)  PDF (1263 KB)  ( 294 ) 1078 Effects of Selegiline Combined with Pramipexole on Behavioral and Psychological Symptoms Cognitive Disorders and ADL of Patients with Parkinson's Disease Complicated with Sleep Disorders WANG Yang, XU Bing, ZHOU Jin, et al DOI: 10.3969/j.issn.1006-6233.2019.07.005 Objective: To investigate the effects of selegiline combined with pramipexole on behavioral and psychological symptoms, cognitive disorders and activity of daily living of patients with Parkinson's disease (PD) complicated with sleep disorders. Methods: 80 patients with PD and sleep disorders in the hospital were divided into control group (n=40) and observation group (n=40) by the simple random grouping method. The control group was treated with pramipexole while the observation group was treated with selegiline combined with pramipexole. Scores of neuropsychiatric inventory (NPI), mini-mental state examination (MMSE), Pittsburgh sleep quality index (PSQI), Epworth sleepiness scale (ESS), Unified Parkinson’s Disease Rating Scale (UPDRS-III) and activities of daily living (ADL), as well as adverse reactions were compared between the two groups. Results: Scores of NPI, PSQI, ESS and UPDRS-III of the observation group were lower than those of the control group after treatment (P<0.05), while scores of MMSE and ADL were higher than those of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Selegiline combined with pramipexole can significantly improve the behavioral and psychological symptoms of patients with PD and sleep disorders, reduce cognitive disorders, and enhance activity of daily living, without obvious adverse reactions. 2019 Vol. 25 (7): 1078-1080 [Abstract] ( 200 ) HTML (1 KB)  PDF (1240 KB)  ( 297 ) 1081 Diagnostic Value of Combined Detection of Serum HE4 TK1 and CA199 for Ovarian Cancer WANG Chunyang, WANG Yu, et al DOI: 10.3969/j.issn.1006-6233.2019.07.006 Objective: To explore the diagnostic value of combined detection of serum human epididymis protein 4 (HE4), cytoplasmic thymidine kinase (TK1) and carbohydrate antigen 199 (CA199) for ovarian cancer. Methods: 124 cases of patients with pelvic tumors who were undergoing surgical treatment in our hospital from March 2016 to March 2018 were selected for the study. According to the results of postoperative pathological examination, the patients were divided into ovarian cancer group (n=64) and benign ovarian disease group (n=60). And another 66 healthy women who were for physical examination at the same time were randomly selected as control group. The levels of serum HE4, TK1 and CA199 were compared among the three groups. The receiver operating characteristic curve was used to evaluate the diagnostic value [sensitivity, specificity, and area under curve (AUC)] of single index detection and combined detection of the three indexes. Results: The levels of serum HE4, TK1 and CA199 and positive rate of each single index in ovarian cancer group were higher than those in benign ovarian disease group and control group (P<0.05), and the levels of serum HE4, TK1 and CA199 and positive rate of each single index in benign ovarian disease group were higher than those in control group (P<0.05). The sensitivity and AUC of combined detection of the three indexes for ovarian cancer were higher than those of single index detection (P<0.05), and there was no significant difference in the specificity compared with that of single index detection (P>0.05). Conclusions: The expression levels of serum HE4, TK1 and CA199 are different in patients with ovarian cancer, patients with benign ovarian disease and healthy people. They can be used as sensitive indicators for ovarian cancer diagnosis, and combined detection of the three indexes can improve the diagnostic accuracy. 2019 Vol. 25 (7): 1081-1084 [Abstract] ( 158 ) HTML (1 KB)  PDF (1412 KB)  ( 230 ) 1085 Effect of Mexiletine Combined with Shensong Yangxin Capsule on Heart Function and Therapeutic Effect of NSTEMI Patients with Arrhythmia WANG Feng, MA Fengyun, ZHAO Xizhe DOI: 10.3969/j.issn.1006-6233.2019.07.007 Objective: To analyze the effect of mexiletine combined with Shensong Yangxin capsule on therapeutic effect and cardiac function in patients with non-ST-segment elevation myocardial infarction (NSTEMI) complicated with arrhythmia. Methods: 178 NSTEMI outpatients with arrhythmia from June 2015 to June 2018 in our hospital were selected as the research subjects. According to the randomized parallel control design and simple random grouping method, the patients were divided into control group treated with mexiletine and study group treated with mexiletine combined with Shensong Yangxincapsule, with 89 cases in each group. The clinical efficacy, electrocardiogram indexes, cardiac function indexes before and after treatment and adverse reactions during treatment were compared between the two groups. Results: The total effective rate of the study group was 97.75%, which was significantly increased compared with 86.52% of the control group (P<0.05). Compared with before treatment, standard diviation of NN intervals (SDNN) and standard diviation average of NN intervals (SDANN) were significantly increased in both groups after treatment (P<0.05), but there was no significant difference between the study group and the control group after treatment (P>0.05). Compared with before treatment, the levels of left ventricular ejection fraction (LVEF), left ventricular systolic diameter (LVDs) and left ventricular diastolic diameter (LVDd) in the two groups were significantly increased after treatment, and the levels in the study group were significantly increased compared with control group after treatment(P<0.05). The incidence of adverse reactions was 3.37% in the study group and 6.74% in the control group, which showed no significant difference between the two groups (P>0.05). Conclusion: Mexiletine combined with Shensong Yangxin capsule can effectively improve the clinical efficacy of NSTEMI patients with arrhythmia. It plays an important role in improving cardiac function and anti-arrhythmia, and does not cause serious adverse reactions. It suggests that this therapy has good drug safety and is worthy of clinical application. 2019 Vol. 25 (7): 1085-1087 [Abstract] ( 369 ) HTML (1 KB)  PDF (1247 KB)  ( 463 ) 1088 Effect of Shock Wave Therapy on Meniscus Healing and Knee Function Recovery after Meniscus Laceration REN Xiaodong, WANG Wei, NIU Yali DOI: 10.3969/j.issn.1006-6233.2019.07.008 Objective: To investigate the effect of shock wave therapy on meniscus healing and knee function recovery after meniscus laceration. Methods: 140 patients with meniscus laceration admitted to our hospital from October 2016 to October 2018 were retrospectively analyzed. All patients were divided into control group and experimental group according to the difference of treatment methods. The control group underwent meniscus repair under knee arthroscopy, while the experimental group underwent shock wave therapy at the affected area 2 to 6 weeks after operation on the basis of the control group. HSS score and Lysholm score were used to evaluate the knee joint function. The knee function and meniscus healing were recorded before and 6 weeks after operation. HSS score and Lysholm score were used to evaluate the knee joint function. Results: There was no significant difference in Lysholm score and HSS score between the two groups before surgery (all P>0.05). Lysholm score and HSS score at 6 weeks after surgery in both groups were significantly better than those before surgery in this group (all P<0.05). Lysholm score and HSS score of the experimental group at 6 weeks after surgery were significantly better than those of the control group at the same period (all P<0.05). The positive and negative rates of HSS in the experimental group were 87.14%, which was significantly higher than that in the control group (χ2=5.638, P<0.05). The Lysholm positive and negative rates in the experimental group were 75.71%, significantly higher than those in the control group (χ2=5.235, P<0.05). Conclusion: The knee arthroscopic meniscus repair combined with shock wave therapy can effectively improve the joint function of the patients with meniscus laceration, and greatly promote the meniscus repair. This scheme not only has less trauma, but also has less side effects. It is worth popularizing and applying widely in clinic. 2019 Vol. 25 (7): 1088-1090 [Abstract] ( 301 ) HTML (1 KB)  PDF (1249 KB)  ( 319 ) 1091 Evaluation of Left Ventricular Systolic Function in Patients with Ischemic Cardiomyopathy by Three-dimensional Speckle Tracking Imaging and its Relationship with the Serum NT-proBNP Level LIN Wenhai, YE Tingfang, WU Deli DOI: 10.3969/j.issn.1006-6233.2019.07.009 Objective: To investigate the relationship between left ventricular systolic function in patients with ischemic cardiomyopathy (ICM) evaluated by three-dimensional speckle tracking imaging (3D-STI) and the serum N-terminal pro-brain natriuretic peptide (NT-proBNP) level. Methods: A total of 52 patients with ICM diagnosed in the hospital during the period from February 2015 to February 2018 were selected as the observation group, and 30 healthy volunteers were selected as the control group. The three-dimensional full-volume dynamic images of the left ventricle were obtained by 3D-STI, and they were sent to work station for off-line analysis. The left ventricular global longitudinal strain (GLS), left ventricular global circumferential strain (GCS), left ventricular global radial strain (GRS) and left ventricular global strain (GS) were calculated and compared between the two groups. The NT-proBNPlevels in both groups were measured by photo-chemistry and the relationship between left ventricular systolic function and NT-proBNP level in the observation group was analyzed. Results: GLS, GCS and GS in the observation group were significantly higher than those in the control group (P<0.05), while the GRS was significantly lower than the control group (P<0.05). Serum NT-proBNP levels were significantly higher than those in the control group (P<0.05). GLS, GCS and GS were positively correlated with the serum NT-proBNPlevel in the observation group (r=0.416, 0.387, 0.424, P<0.05), while GRS was negatively correlated with the serum NT-proBNP level (r=-0.496, P<0.05). Conclusion: 3D-STI can better evaluate the left ventricular systolic function in patients with ICM. GLS, GCS and GS are positively correlated with the serum NT-proBNP level, while GRS is negatively correlated with the serum NT-proBNP level. Therefore, the serum NT-proBNP level can be used as an auxiliary index for evaluating the left ventricular systolic function in 2019 Vol. 25 (7): 1091-1094 [Abstract] ( 100 ) HTML (1 KB)  PDF (1275 KB)  ( 256 ) 1095 Effect of Ultrasound-guided Bilateral TAP Block Combined with Ⅲ H Nerve Block on Incision Pain after Cesarean Section NIE Bin, CHI Xiaohui DOI: 10.3969/j.issn.1006-6233.2019.07.010 Objective: To investigate the effect of ultrasound guided bilateral TAP block combined with ⅢH nerve block on incision pain after cesarean section. Methods: 60 cases of cesarean section patients admitted to our hospital from June 2015 to June 2018 were randomly divided into control group and experimental group according to random number table method. All patients were anesthetized with combined spinal-epidural anesthesia. All patients in the control group underwent ultrasound-guided bilateral TAP block with 0.5% ropivacaine of 20mL on each side, while those in the experimental group underwent ultrasound-guided bilateral TAP block with 0.5% ropivacaine of 20 ml on each side. NRS score of rest and exercise in each group within 48 hours after surgery was recorded, exhaust time and first time to the ground of the two groups were recorded, and satisfaction with postoperative analgesia and adverse reactions of the two groups were compared. Results: There was no significant difference in NRS score between the two groups at other time points (all P>0.05). After treatment, there was no significant difference between the two groups in analgesia satisfaction, first exhaust time and first ground floor time (all P>0.05). After treatment, there was no significant difference in sedation score and adverse reactions between the two groups (all P>0.05). Conclusion: Compared with bilateral TAP block, ultrasound-guided bilateral TAP block combined with Ⅲ H block can not effectively improve the analgesic effect of incision after cesarean section. 2019 Vol. 25 (7): 1095-1097 [Abstract] ( 245 ) HTML (1 KB)  PDF (1412 KB)  ( 263 ) 1098 Effect of Proximal Femoral Nail Antirotation and Artificial Femoral Head Arthrolastyon Hip Joint Function ADL score and Postoperative Complications in Elderly Patients with Unstable Intertrochanteric Femoral Fracture MA Chuntao, TAN Yu, XIAO Yuzhi, et al DOI: 10.3969/j.issn.1006-6233.2019.07.011 Objective: To analyze the effects of proximal femoral nail antirotation and artificial femoral head arthrolasty on hip joint function, Ability of Daily Life (ADL) score and postoperative complications in elderly patients with unstable intertrochanteric femoral fracture. Methods: A total of 94 elderly patients with unstable intertrochanteric femoral fracture in the hospital from January 2014 to October 2017 were enrolled in this study. According to the surgical methods, 50 patients treated with proximal femoral nail antirotation were included in group A.44 patients treated with artificial femoral head arthrolasty were included in group B.The operation condition, hip joint function, ADL score and postoperative complications were compared between the two groups. Results: The operation time, intraoperative blood loss, hip joint function scores at 1 month and 3 months after operation and ADL score at 3 months after operation in group A were significantly lower than those in group B, while postoperative rest time was significantly long than that ingroup B (P<0.05).There was no significant difference in length of stay, the hip joint function score at 1 year after surgery, the ADL score at 6 months and 1 year after surgery, incidence of complications between the two groups (P>0.05). Conclusion: Both proximal femoral nail antirotation and artificial femoral head arthrolasty are effective for the treatment of elderly patients with unstable intertrochanteric femoral fracture, and they all have their characteristics. Comprehensive consideration should be performed clinically according to the actual situation of patients. 2019 Vol. 25 (7): 1098-1101 [Abstract] ( 109 ) HTML (1 KB)  PDF (2386 KB)  ( 280 ) 1102 Expression of KI67 Protein in Ovarian Cancer and its Correlation with Clinicopathological Features and Prognosis MA Chunyan DOI: 10.3969/j.issn.1006-6233.2019.07.012 Objective: To investigate the expression of KI67 protein in ovarian cancer and its correlation with clinicopathological features and prognosis. Methods: 60 patients with ovarian cancer admitted to our hospital from January 2013 to December 2014 were selected as the study subjects, and 30 patients with benign ovarian tumors treated in the same period were selected as the control group. The expression of KI67 protein in different ovarian tissues was measured by immunofluorescence labeling, and its correlation with clinicopathological characteristics and prognosis was further analyzed. Result: The expression level of KI67 protein in ovarian cancer tissue was higher than that in benign ovarian tumor tissue and normal ovarian tissue, while that in benign ovarian tumor tissue was higher than that in normal ovarian tissue (P<0.05). The expression level of KI67 protein in ovarian cancer tissues of patients with ovarian cancer was higher than that of patients with tumor diameter > 3cm than that of patients with tumor diameter > 3cm, TNM stage > (III+ IV) than (I+ II), low differentiation than high and moderate differentiation (P<0.05). Within 4 years, the expression level of KI67 protein in the death group was higher than that in the survival group (P<0.05). Conclusion: KI67 protein is highly expressed in ovarian cancer tissues and is associated with the occurrence, development and prognosis of ovarian cancer. 2019 Vol. 25 (7): 1102-1104 [Abstract] ( 270 ) HTML (1 KB)  PDF (1222 KB)  ( 446 ) 1105 Curative Effect of Pterygium Excision Combined with Limbal Stem Cell Transplantation in Elderly Patients with Pterygium and the Effect on Tear Film Function MA Liming, LI Bo DOI: 10.3969/j.issn.1006-6233.2019.07.013 Objective: To analyze the curative effect of pterygium excision combined with limbal stem cell transplantation in elderly patients with pterygium and the effect on tear film function. Methods: 84 elderly patients with pterygium were divided into the observation group (n=42, a total of 56 diseased eyes treated by pterygium excision combined with limbal stem cell transplantation) and the control group (n=42, a total of 54 diseased eyes treated by pterygium excision alone) by simple random number table method. The tear film stability , tear film function, uncorrected visual acuity (UCVA), corneal astigmatism degree (CAD), complications and recurrence rate were observed. Results: SIT and BUT decreased in both groups at 4 weeks after treatment, while CFS and OSDI scores increased (P<0.05). SIT, BUT, CFS and OSDI scores returned to the levels before treatment at 8 weeks after treatment (P>0.05). The above indexes in the observation group were superior to those in the control group at 4 weeks after treatment (P<0.01). There was a significant difference in the grade of tear film function between the two groups at 12 weeks after treatment (P<0.05), and the ratio of grade I～II in observation group was higher than that in the control group (P<0.05). The UCVA increased and the CAD decreased at 4 weeks, 8 weeks and 12 weeks after treatment (P<0.05), but there was no significant difference between the two groups (P>0.05). The incidence of complications and recurrence rate in the observation group were lower than those in the control group at 12 weeks after treatment (P<0.05). Conclusion: The curative effect of pterygium excision combined with limbal stem cell transplantation is good in elderly patients with pterygium. The combined treatment is beneficial to recovery of tear film function and visual acuity, and it can reduce complications and recurrence rate. 2019 Vol. 25 (7): 1105-1107 [Abstract] ( 101 ) HTML (1 KB)  PDF (1241 KB)  ( 234 ) 1108 Effects of Tiotropium Bromide Combined with Symbicort Turbuhaler on Lung Function, Exercise Tolerance and Adverse Reactions in Patients with Chronic Obstructive Pulmonary Disease LIU Bin, RAN Xiangui, XING Qingfeng, et al DOI: 10.3969/j.issn.1006-6233.2019.07.014 Objective: To explore the effects of tiotropium bromide combined with budesonide formoterol powder inhalant (trade name: symbicort turbuhaler) on lung function, exercise tolerance and adverse reactions in patients with chronic obstructive pulmonary disease (COPD). Methods: A total of 118 patients with acute exacerbation of COPD were selected and randomly grouped (observation group, n=59; control group, n=59). All patients were given routine symptomatic treatment, and control group was given tiotropium inhalation treatment, and observation group was given symbicort turbuhaler on the basis of above treatment. The lung function indexes, exercise tolerance, arterial gas blood analysis indexes and serum biochemical indexes were observed in the two groups before treatment and after 14 d of treatment, and the medicinal safety was evaluated in the two groups. Results: After 14 d of treatment, the lung function indexes of mean pulmonary artery pressure (MPAP), pulmonary artery systolic pressure (PASP) and pulmonary artery diastolic pressure (PADP) were significantly decreased in the the two groups (P<0.05), and the 6min walking distance (6MWD) score was improved (P<0.05), and the arterial gas blood analysis index of arterial partial pressure of oxygen (PaO2) was significantly increased (P<0.05) while the arterial partial pressure of carbon dioxide (PaCO2) was significantly decreased (P<0.05), and the levels of serum tissue inhibitor of metalloproteinase-1 (TIMP-1), matrix metalloproteinase-9 (MMP-9) and advanced glycation end products (AGEs) were significantly decreased in the two groups (P<0.05) while the level of soluble receptor for advanced glycation end-product (sRAGE) was significantly increased (P<0.05), and the changes of the above indicators in observation group were significantly greater than those in control group (P<0.05). The total incidence rates of adverse reactions in observation group and control group were 10.17% and 6.78% respectively (P>0.05). Conclusions: Tiotropium bromide combined with symbicort turbuhaler can treat patients with acute exacerbation of COPD, and it can significantly improve lung function, enhance exercise tolerance, and reduce lung inflammatory response, and it has good clinical medicinal safety, thus it is worthy of promotion. 2019 Vol. 25 (7): 1108-1112 [Abstract] ( 466 ) HTML (1 KB)  PDF (1265 KB)  ( 425 ) 1113 Dosimetric conparison of Three-dimensional anformal ladicthempy and Intensity mcdulatcd mditon Therapy in Rectalcaner ZHANG Wenbo, LI Meng, WANG Lizhi, et al DOI: 10.3969/j.issn.1006-6233.2019.07.015 Objective: To analyze the preoperative radiotherapy process in patients with rectal cancer, 3D-CRT and IMRT plan to treat the target area and the proximity of sensitive organs to receive the difference in irradiation dose.Methods: Twenty-one rectal cancer patients hospitalized in our department (chemotherapy center) from 2017 to 2018.Scan the CT image of the affected area and delineate the target area and adjacent sensitive organs. The total dose is 5000CGy. Design 3D-CRT and coplanar and other wild IMRT plans to evaluate HI (uniformity), CI (conformity), (Dmax) maximum exposure dose, (Dmin) minimum exposure dose, (Dmean) average The exposure dose and the exposure V (volume) of the adjacent sensitive organs were obtained and compared. Results: The 3D-CRT was worse than the target conformation of 5F-IMRT, 7F-IMRT, and 9F-IMRT; the IMRT was significantly better than the 3D-CRT for the adjacent sensitive organs, P<0.05. Conclusion: For the radiotherapy of patients with rectal cancer, the 3D-CRT plan is significantly worse than the IMRT plan in both the conformality and the protection of the adjacent sensitive organs. According to the comprehensive evaluation of all aspects, 5F is better than 7F and 9F. Not only is it efficient and reduces the economic burden of patients, it is clinically worthy of adoption. 2019 Vol. 25 (7): 1113-1115 [Abstract] ( 129 ) HTML (1 KB)  PDF (1240 KB)  ( 521 ) 1116 Effect of Statine on Cognitive Function and Plasma IL-6 IL-10 BDNF and S100 Beta in Elderly Patients after Hip Arthroplasty JING Xu DOI: 10.3969/j.issn.1006-6233.2019.07.016 Objective: To investigate the correlation between MMSE score and plasma IL-6,IL-10,BDNF and S100β after hip arthroplasty in elderly patients and the improvement of ulinastatin. Methods: 92 elderly patients undergoing hip arthroplasty in our hospital from April 2016 to April 2018 were selected and randomly divided into control group and experimental group according to random number table method.All patients were given intravenous access and multi-function monitor for vital signs monitoring. The experimental group was given 5 000 U/kg Ulinastatin intravenously before and after anesthesia, while the control group was given the same volume of physiological saline. Simple mental state scale was used to evaluate the cognitive function of the two groups before and after operation. The changes of plasma levels of IL-6, IL-10, BDNF and S100 beta were compared between the two groups before and after operation. Results: There were 7 cases(15.22%)in the control group and 1 cases (2.17%) in the trial group with postoperative cognitive impairment. The difference between the two groups was statistically significant ( P<0.05). There was no significant difference in MMSE score between the two groups before operation (t = 0. 329, P>0. 05). The MMSE score of the control group was (25.34±1.28) on the 3rd day after operation, which was significantly lower than that before the treatment (29.32±2.34), and the difference was statistically significant (t=4.283, P<0.05). The MMSE score of the patients in the trial group was (28.52±1.27) on the 3rd day after operation, which was significantly higher than that in the control group (25.34±1.28), and the difference was statistically significant (t = 4.132, P<0. 05). The levels of IL-6 and IL-10 at the end of operation and on the third day after operation in both groups were significantly higher than those before treatment (P<0. 05). The IL-6 of the patients in the trial group was significantly lower than that in the control group at the end of operation and the third day after operation (all P<0. 05). On the 3rd day after operation, the level of BDNF was significantly lower than that before operation (all P<0. 05). The levels of S100β at the end of operation in both groups were significantly higher than those before treatment, and the levels of S100β at the end of operation in the trial group were significantly lower than those in the control group (all P<0.05). Conclusion: The use of ulinastatin in perioperative hip replacement patients can effectively improve their cognitive function and plasma IL-6,IL-10,BDNF and S100β levels, which is worthy of extensive clinical application. 2019 Vol. 25 (7): 1116-1119 [Abstract] ( 152 ) HTML (1 KB)  PDF (1254 KB)  ( 250 ) 1120 Study on the Effect of Neuroprotective Factor on the Hearing of Newborns with Cytomegalovirus Infection HU Xiuming, DONG Xuyan DOI: 10.3969/j.issn.1006-6233.2019.07.017 Objective: To explore the effect of neuroprotective factor on the hearing of newborns with Cytomegalovirus Infection. Methods: 78 cases newborns with congenital cytomegalovirus infection were collected.All the patinets were divided into 2 groups. The patints of the 2 groups were treated with ganciclovir routinely.The study group patinets were given neuroprotective factors on the based of the above treatment.The therapeutic effects of the two groups were compared. Results: The pass rate of hearing screening of the study group was significantly higher than that in the control group after the birth of 6 days.The V wave threshold of ABR testing of the study group was significantly lower than the control group in the 3 months ans 6 months after birth. Conclusion: Nerve protection factor can reduce the hearing damage in congenital CMV infection in a certain extent,can have very good protection effect on the patients'auditory system,which is worthy to be populared and applied in clinic. 2019 Vol. 25 (7): 1120-1121 [Abstract] ( 102 ) HTML (1 KB)  PDF (1224 KB)  ( 203 ) 1122 Correlation Analysis between LH E2 and P in Follicular Fluid and Female Age XU Maoqing, et al DOI: 10.3969/j.issn.1006-6233.2019.07.018 Objective: To analyze the correlation between LH, E2 and P in follicular fluid and female age by measuring the levels of luteotropic hormone (LH), estradiol (E2) and progesterone (P) in follicular fluid of infertile women in different age groups. Methods: A total of 140 patients who received IVF-ET/ICSI assisted pregnancy from July 2017 to June 2018 were enrolled in the study. They were divided into groups A, B, and C according to age, and group A (<35 years old, n=55), group B (35-39 years old, n=55), group C (>39 years old, n=30), ELISA was used to detect the levels of LH, E2 and P in follicular fluid on day of egg retrieval, and three groups of infertility were analyzed. General information of patients with disease, the difference of LH, E2, P levels of follicular fluid on the day of egg retrieval and comparison of the number of eggs obtained in different age groups, fertilization rate, available embryo rate, high quality embryo rate, clinical pregnancy rate. Results: There were no significant differences in BMI between the general data of group A, group B and group C (P>0.05), but there were significant differences in age, basal serum follicle stimulating hormone (bFSH) and antral follicle (AFC). P<0.05); the difference of LH level and E2 level in follicular fluid of group A, group B and group C was statistically significant (P<0.05), but the level of follicular fluid P in the three groups was taken. The difference was not statistically significant (P>0.05). According to Spearman correlation analysis, the LH level of follicular fluid was positively correlated with female age (r=0.335, P<0.05), and E2 level was negatively correlated with female age (r= -0.418, P<0.05), there was no correlation between P level and female age (r=0.045, P=0.523). There were significant differences in the number of eggs, fertilization rate and multi-PN fertilization rate in group A, B and C. Significance (P<0.05), but there was no significant difference in available embryo rate, high quality embryo rate and clinical pregnancy rate (P>0.05). Conclusion: The levels of LH and E2 in follicular fluid are related to age. The ovarian reserve function is related to age, bFsh and AFC. The age of 35~39 years old is the beginning of the decline of ovarian reserve function, and the ovarian response (reflected by the number of eggs) is also followed. Decreased, especially in women over the age of 39, ovarian reserve dysfunction is evident, and ovarian response is also dramatically reduced. 2019 Vol. 25 (7): 1122-1125 [Abstract] ( 127 ) HTML (1 KB)  PDF (1270 KB)  ( 228 ) 1126 Application Value of Mammary Oxygenation Function Imaging in Screening of Breast Diseases ZHOU Lihong, WANG Min, SUI Wendong, et al DOI: 10.3969/j.issn.1006-6233.2019.07.019 Objective: To explore the application value of mammary oxygenation function imaging in screening breast diseases. Methods: Data analysis and follow-up were carried out on the patients who underwent mammary oxygenation imaging examination. The results of mammary oxygenation examination were compared with those of follow-up, and their value in screening breast diseases was analyzed. Results: 246 cases were normal, the diagnostic coincidence rate was 100%; mild breast hyperplasia, BI-RADS grade II, 1890 cases, the diagnostic coincidence rate was 100%; 1087 cases of benign breast nodules, the diagnostic coincidence rate was 95.01%; 24 cases of breast cancer, BI-RADS grade IV, the diagnostic coincidence rate was 92.31%. Conclusions: Breast oxygenation imaging is non-invasive, painless, sensitive and accurate, and can be used as a routine screening method for breast cancer in physical examination department. 2019 Vol. 25 (7): 1126-1128 [Abstract] ( 112 ) HTML (1 KB)  PDF (2990 KB)  ( 342 ) 1129 Evaluation Value of Nutrition Risk Screening Scale combined with Albumin Level Monitoring for Nutritional Status of Patients with Liver Cancer before and after Surgery HU Jiao, LUO Yanli, XIAO Fengming, et al DOI: 10.3969/j.issn.1006-6233.2019.07.020 Objective: To analyze the evaluation value of nutrition risk screening (NRS-2002) combined with albumin (ALB) level monitoring for nutritional status of liver cancer patients before and after surgery. Methods: A total of 300 patients with liver cancer who underwent surgery admitted to the hospital were enrolled. NRS-2002 and ALB level monitoring were performed to evaluate nutritional status of the patients before and after surgery. The evaluation results of NRS-2002 and NRS-2002 combined with ALB levels monitoring for nutritional status were observed. The detection rate of nutritional risk, traditional single indexes [body mass index (BMI), triceps skinfold thickness (TSF), arm muscle circumference (AMC), lymphocyte count, hemoglobin (Hb)] of patients with or without nutritional risk before and after surgery were compared. Results: The detection rate of nutritional risk before surgery was significantly lower than that after surgery (76.00% vs 86.00%) (P<0.05). Before and after surgery, BMI, TSF, AMC, lymphocyte count and Hb levels in patients with nutritional risk were significantly less than those in patients without nutritional risk evaluated by NRS-2002 combined with ALB (P<0.05). Conclusion: The risk of postoperative malnutrition in liver cancer patients is increased. NRS-2002 combined with ALB level monitoring is more comprehensive in evaluation of the presence or absence of nutritional risk in liver cancer patients, with high accuracy. The application value is important. 2019 Vol. 25 (7): 1129-1131 [Abstract] ( 105 ) HTML (1 KB)  PDF (1244 KB)  ( 231 ) 1132 Expression and Clinical Significance of CD68 and bFGF in Benign Prostatic Hyperplasia Tissues HAN WeiJun, et al DOI: 10.3969/j.issn.1006-6233.2019.07.021 Objective: To explore the changes of CD68 and bFGF levels in tissues of patients with benign prostatic hyperplasia and their effects in clinical practice. Methods: 68 cases of patients with benign prostatic hyperplasia confirmed by pathological biopsy who were treated in our hospital from June 2016 to December 2017 were selected as observation group, and another 52 cases of patients with prostatic inflammation were included in control group. The prostate volume and IPSS, urinary symptoms and pain and discomfort scores were analyzed in the two groups. The changes of CD68 and bFGF levels in prostate tissues were determined by immunohistochemistry in the two groups. Results: Compared with control group, the prostate volume of benign prostate patients was increased significantly (P<0.05). IPSS, urinary symptoms and pain discomfort scores were increased significantly (P<0.05). There was no statistically significant difference in the pain and discomfort scores between the two groups (P>0.05). In the immunohistochemistry experiment, compared with control group, the levels of CD68 and bFGF in the tissues of patients with benign prostate were significantly increased (P<0.05). The benign prostate status was positively correlated with the concentrations of CD68 and bFGF in the tissues (r=0.426, 0.401, P<0.05). Conclusions: The changes of CD68 and bFGF levels in tissues of patients with benign prostate are positively correlated with pathological status, and they may provide a reference for the diagnosis and treatment of patients with benign prostatic hyperplasia in clinical practice. 2019 Vol. 25 (7): 1132-1134 [Abstract] ( 99 ) HTML (1 KB)  PDF (1403 KB)  ( 194 ) 1135 Effects of Rational Emotional Therapy and Er Laser Therapy on Dental Anxiety of Teenagers with Orthodontic Window Opening Wang Yangyang, Zhao Chanyuan, Chen Xibo, et al DOI: 10.3969/j.issn.1006-6233.2019.07.022 Objective: To explore the methods of reducing dental anxiety (DA) in adolescent orthodontic window-opening patients. Methods: 200 patients with orthodontic fenestration were analyzed retrospectively randomly, and divided into 4 groups according to the different treatment methods. Group A: fenestration under Cymbidium anesthesia; Group B: fenestration under Er laser; Group C: reasonable emotional therapy was given to the patients before fenestration under Cymbidium anesthesia; Group D: fenestration under Er laser therapy after rational emotional therapy. Group A was investigated by symptom checklist 90 (self rating scale), and group C was investigated by Cognitive Emotion Regulation Questionnaire (Chinese version). Modified dental anxiety scale (MDAS) was used to observe the changes of DA level in the four groups at different stages. The data before and after window opening were compared and analyzed statistically. Results: In terms of five factors (somatization, depression, anxiety, hostility and interpersonal sensitivity) in SCL-90 scores of orthodontic patients, the scores of adolescents in group C were significantly lower than those in group A (all P < 0.05). the scores of positive coping and negative coping in group C were higher and lower than those in group A (all P < 0.05). During the follow-up visit, the DA values of the four groups showed a downward trend as a whole, and among the four groups, group D had the highest downward trend, followed by group B and group C. Even in the same group, the effect of treatment is also very different (P<0.05). Conclusions: In order to reduce the dental fear of adolescent orthodontic fenestration patients, rational emotional therapy and Er laser therapy should be used, and the combination of them can achieve the best results. 2019 Vol. 25 (7): 1135-1139 [Abstract] ( 113 ) HTML (1 KB)  PDF (1267 KB)  ( 184 ) 1140 Clinical Efficacy Traumatic Cervical Spinal Cord Injury with Posterior Cervical Single Door and Pedicle Screw Internal Fixation ZENG Hui, YAO Chuliang, YANG Yanxin, et al DOI: 10.3969/j.issn.1006-6233.2019.07.023 Objective: To explore the clinical effect of single open-door Expansive Laminoplasty combined with pedicle screw fixation in the treatment of traumatic long cervical spinal cord injury. Methods: From June 2012 to June 2017, 86 patients with traumatic long cervical spinal cord injury were selected and divided into observation group (n = 42) and control group (n = 44).The patients in the observation group were treated with single open-door Expansive Laminoplasty combined with pedicle screw fixation, while the patients in the control group were treated with nail shock therapy. The patients in the two groups were followed up for 12~36 months after the treatment. The clinical efficacy of the two groups was compared. To compare the clinical efficacy the Japanese Orthopaedic Association Scores (JOA) and the incidence of complications of the two groups. Results: The excellent and good rate of clinical effect in the observation group was significantly higher than that in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in JOA scores between the two groups before treatment (P>0.05). The JOA scores of the two groups were significantly improved after 12 months of follow-up , and the difference was statistically significant (P<0.05). The JOA score in the observation group was significantly higher than that in the control group after 12 months follow-up (P<0.05). The incidence of total complications in the observation group was significantly lower than that in the control group (P<0.05). Conclusion: The treatment of traumatic long cervical spinal cord injury with single open-door expansive laminoplasty combined with pedicle screw fixation has a good clinical effect. It can effectively improve the cervical spinal cord function, reduce the incidence of complications and improve the quality of life of the patients. 2019 Vol. 25 (7): 1140-1143 [Abstract] ( 96 ) HTML (1 KB)  PDF (1243 KB)  ( 259 ) 1144 The Application Analysis of Oxycodone Combined with Propofol in Female Hysteroscopic Surgery and the Influence on Blood Gas Indexes and Perioperative Chills CAO Weimin, FAN Junfeng DOI: 10.3969/j.issn.1006-6233.2019.07.024 Objective: To analyze the application of oxycodone combined with propofol in female hysteroscopic surgery and the influence on blood gas indexes and perioperative chills. Methods: A total of 140 patients who underwent hysteroscopic surgery in Xiangyang Maternal and Child Health Hospital from April 2017 to July 2018 were divided into the observation group and the control group bysimple random groupingmethod, 70 cases in each group. The control group was given propofol anesthesia induction and maintenance. On this basis, the observation group was additionally given oxycodone. The condition of anesthesia, blood gas indexes, perioperative anesthesia and other anesthesia-related complications were compared between the two groups. Results: There were no significant differences in blood gas analysis indexes between the two groups during anesthesia recovery time or at different time points (P>0.05). The induction dose, maintenance dose and dose per unit time of propofol in the observation group were significantly fewer than those in the control group. The incidence of chills, severity score and VAS score were significantly lower than those of the control group (P<0.05). There was no significant difference in the incidence of single anesthesia-related complicationbetween the two groups (P>0.05), but the overall incidence of other anesthesia-related complications in the observation groupwas significantly lower than that in the control group (P<0.05). Conclusion: In female hysteroscopic surgery, the combined use of oxycodone can reduce the dosage of propofol, obtain better analgesic efficacy, reduce the risk of chills and anesthesia-related complications, compared with single propofol anesthesia. 2019 Vol. 25 (7): 1144-1146 [Abstract] ( 125 ) HTML (1 KB)  PDF (1236 KB)  ( 200 ) 1147 The Value of Megakaryocyte Morphology in Bone Marrow Biopsy in Differential Diagnosis of Primary Thrombocytosis, Polycythemia Vera and Primary Myelofibrosis BAO Shuzhen, ZHANG Rufeng, MA Fengying, et al DOI: 10.3969/j.issn.1006-6233.2019.07.025 Objective: To analyze the diagnostic value of megakaryocyte morphology in bone marrow biopsy in differentiating primary myelofibrosis, polycythemia vera andprimary thrombocytosis. Methods: The clinical data of 78 patients with primary myelofibrosis (group A), 52 patients with polycythemia vera (group B) and 63 patients with primary thrombocytosis (group C) were collected retrospectively. The differences of blood routine, bone marrow smear cell count, percentage of megakaryocytes and morphological changes in bone marrow biopsy were compared among the three groups. Results: Compared with group A and B, platelet count (PLT) in group C increased significantly (P<0.05); white blood cell count (WBC) in three groups had no significant difference (P>0.05); hemoglobin (Hb) level in group B was significantly higher than that in group A and C, and Hb level in group C was significantly higher than that in group A (P<0.05). There was no significant difference in megakaryocyte count, erythrocyte percentage and granulocyte percentage among the three groups (P>0.05). Compared with group B and C, the percentage of type I and VI megakaryocytes in group A increased significantly (P<0.05); Compared with group A and C, the percentage of type III megakaryocytes in group B increased significantly (P<0.05); Compared with group A and B, the percentage of type IV and V megakaryocytes in group C increased significantly (P<0.05). Conclusion: In bone marrow biopsy, the morphology and percentage of paratrabecular megakaryocytes and nuclear shrinkage megakaryocytes are helpful to differentiate and diagnose primary myelofibrosis. The morphology and percentage of oligophyllotic megakaryocytes are helpful to differentiate and diagnose polycythemia vera. The morphology and percentage of giant multilobular nuclear megakaryocytes are helpful to differentiate and diagnose primary thrombocytosis. 2019 Vol. 25 (7): 1147-1150 [Abstract] ( 98 ) HTML (1 KB)  PDF (1265 KB)  ( 315 ) 1151 The influence of clinicopathologic parameters on prognosis of liver metastasis from colon cancer SUN Zhide , CHENG Limin DOI: 10.3969/j.issn.1006-6233.2019.07.026 Objective: To investigate the effect ofclinicopathologic parameters on prognosis of liver metastasis from colon cancer. Methods: Patients with colorectal cancer liver metastases from February 2010 to January 2015 were enrolled in this study. All patients underwent surgical treatment. The patients were followed up for 1 year and 3 years. Survival time and the univariate analysis were used to check the prognosis of patients related factors. Results: The 1-year survival rate and 3-year survival rate of patients with primary tumor resection was 47.87% and 11.70% respectively.However,The 1-year survival rate and 3-year survival rate of patientsundergoing primary and liver metastasis tumor resection was 65.38% and 46.15%.The results show that the degree of tumor differentiation, CEA, liver resection, interventional therapy and systemic chemotherapy are important factors forprognosis of patients. Conclusion: Patients with liver metastases of colon cancer should be treated with radical surgery as soon as possible,following with intervention therapy, systemic chemotherapy and other methods to promote the survival time. 2019 Vol. 25 (7): 1151-1153 [Abstract] ( 120 ) HTML (1 KB)  PDF (1239 KB)  ( 230 ) 1154 Comparison of renal dynamic imaging and CKD-EPI equation in determining the stage of the patients with chronic kidney disease GAO Jianqing, XIE Peng, HUANG Jianmin, et al DOI: 10.3969/j.issn.1006-6233.2019.07.027 Objective: To compare the accuracy of renal dynamic imaging and chronic kidney disease epidemiology collaboration (CKD-EPI) equation in determining the stage of the patients with chronic kidney disease. Method: A total of 121 patients with chronic kidney disease (CKD) was enrolled, and all the glomerular filtration rate (GFR) of the patients were determined simultaneously by dual plasma sample clearance method, 99mTc-DTPA renal dynamic imaging method and CKD-EPI equation. The dual plasma sample clearance method was used as the reference standard. The accuracy of the other two methods in determining the stage of the chronic kidney disease was compared and the comparison was repeated based on difference stage. Results: The accuracy of renal dynamic imaging and the CKD-EPI equation was 65.29% and 84.29%, respectively (P=0.001＜0.05). The advantage of CKD-EPI equation was reflected equation was 65.29% and 84.29%, respectively (P=0.000＜0.05). The advantage of CKD-EPI equation was reflected equation was 65.29% and 84.29%, respectively (P=0.000＜0.05). The advantage of CKD-EPI equation was reflected mainly in the stage of CKD4 and CKD5 (P=0.016 and P=0.031, respectively), while there was no obviously significant difference in the other stages (all P>0.05). Conclusion: The CKD-EPI equation showed better performance in determining the stage of the patients with chronic kidney disease. So the CKD-EPI equation may be the priority in clinical practice because of the accuracy and the simplicity. 2019 Vol. 25 (7): 1154-1157 [Abstract] ( 110 ) HTML (1 KB)  PDF (1277 KB)  ( 360 ) 1158 Comparison between High-flow Nasal Cannula and CPAP in Post-operative Congenital Heart Disease Children with Severe Type I Respiratory Failure SONG Hang , LI Qing, GUO Shiyong, Wu Yi DOI: 10.3969/j.issn.1006-6233.2019.07.028 Objective: To Compare the difference between the support effects of high-flow nasal cannula(HFNC) and CPAP in post-operative congenital heart disease(CHD) children with severe type I respiratory failure. Methods: From January 2018 to December 2018, 44 children were treated with HFNC (22 cases) and CPAP(22 cases) for severe type I respiratory failure after operation of congenital heart disease. PaO2,SpO2,PaCO2,RR,RW score,duration of invasive ventilation, reintubation rate,duration of ICU,hospital stay,comfort score, nasal crush,abdominal distention,regurgitation and aspiration ,gas leakage are compared between the two groups. Results: Comfort score, PaCO2,RR,RW score,nasal crush,abdominal distention,regurgitation and aspiration was lower in the HFNC group. There were no statistical significance in PaO2,SpO2,duration of invasive ventilation, reintubation rate,duration of ICU,hospital stay and gas leakage between the two groups. Conclusion: Comparing the support to post-operative children with CHD and severe type I respiratory failure,HFNC is better than CPAP. 2019 Vol. 25 (7): 1158-1161 [Abstract] ( 170 ) HTML (1 KB)  PDF (1245 KB)  ( 466 ) 1162 Effect of Transrectal Ultrasound Elastography Combined with Prostate Biopsy on Detection Rate of Prostate Cancer ZHANG Guiping, WEI Jie, XU Jie, et al DOI: 10.3969/j.issn.1006-6233.2019.07.029 Objective: To investigate the effect of transrectal Ultrasound Elastography (TRE) combined with prostate biopsy on the detection rate of prostate cancer (PCa), and to provide reference for clinical optimal diagnosis. Methods: 110 patients with suspected prostate cancer were examined by transrectal Ultrasound (TRUS) and TRE respectively, and puncture biopsy guided by TRUS was performed to compare the diagnostic effect of the two methods on PCa. Result: 53 cases Of 110 suspected PCa patients were diagnosed pathologically, accounting for 48.18% (53/110), 49 were benign prostatic hyperplasia (BPH), accounting for 44.55% (49/110), and 8 were chronic prostatitis (CP), accounting for 7.27% (8/110). The sensitivity, specificity and accuracy of TRUS-guided puncture biopsy in the diagnosis of PCa were 75.47% (40/53), 68.42% (39/57), 71.82% (79/110), and the positive and negative predictive values were 68.97% (40/58) and 75.00% (39/52), respectively, which were significantly lower than those of TRE-guided puncture biopsy in the diagnosis of PCa 92.45% (49/53), 94.74% (54/57), 93.64% (103/110), 94.23% (49/52), 93.10% (54/58), the difference was statistically significant (X2= 5.675, 13.134, 18.323, 11.331, 6.877, P<0.05 or <0.001), the number of needles under TRUS guidance was 815, the positive rate of puncture point was 18.77%(153/815), significantly lower than that under TRE guidance, the positive rate of target puncture point was 51.33% (116/226), the difference was statistically significant (X2 = 150.418, P<0.001). Conclusion: TRE-guided prostate biopsy can achieve the target biopsy of the lesion, improve the detection rate of PCa and positive rate of puncture point. It can be used as an effective means of early screening and diagnosis of PCa, and is worthy of clinical application. 2019 Vol. 25 (7): 1162-1165 [Abstract] ( 126 ) HTML (1 KB)  PDF (1940 KB)  ( 240 ) 1166 Related Factors Analysis of Pancreatitis Orhyperamylasemia after ERCP FAN Xiuping, HUANG Xiaoli, LI Xiaohui, et al DOI: 10.3969/j.issn.1006-6233.2019.07.030 Objective: To observe the risk factors of pancreatitis and hyperamylasemia after endoscopic retrograde cholangiopancreatography (ERCP). Methods: The clinical data of 196 patients undergoing ERCP in our hospital from March 2017 to March 2018 were retrospectively analyzed. According to the occurrence of post-ERCP pancreatitis (PEP) and post-ERCP hyperamylasemia (PEPH), the patients were divided into study group (concurrent with PEP or PEPH, n=41) and control group (not concurrent with PEP or PEPH, n=155). The differences in clinical data were compared between the two groups. Logistic regression analysis was used to analyze the risk factors affecting the occurrence of PEP or PEPH. Results: The proportions of patients with pancreatitis history, drinking history, common bile duct stricture, duodenal papillary diverticulum and intubation difficulties in study group were higher than those in control group, and the levels of blood WBC, PLT and Alb and ERCP operation time and frequency of entering pancreiatic duct in study group were greater than those in control group (P<0.05). Logistics regression analysis showed that the pancreatitis history, common bile duct stricture, duodenal papillary diverticulum, intubation difficulty and frequent pancreatic duct entering were independent risk factors for PEP or PEPH (P<0.05). Conclusions: The pancreatitis history, common bile duct stricture, duodenal papillary diverticulum, intubation difficulty and frequent pancreatic duct entering will increase the risk of PEP and PEPH in patients with ERCP. The emphasis should be placed on the above situation and timely intervention should be given to help to improve the prognosis of patients. 2019 Vol. 25 (7): 1166-1169 [Abstract] ( 208 ) HTML (1 KB)  PDF (1238 KB)  ( 438 ) 1170 Application Value Analysis on Color Doppler Ultrasound Diagnostic Apparatus in the Diagnosis of Breast Phylloid Tumors JIANG Guiqiong, et al DOI: 10.3969/j.issn.1006-6233.2019.07.031 Objective: To analyze the application value of color Doppler ultrasound diagnostic apparatus in the diagnosis of breast phylloid tumors. Methods: A retrospective study was conducted to analyze the ultrasonographic and pathological data of 64 patients with breast phyllodes tumors. The data were processed by statistical software. Results: The pathological results showed that among 64 cases of phyllodes tumor of the breast, 10 cases of malignant tumor, 18 cases of borderline tumor, 36 cases of benign tumors, without axillary lymph node enlargement. The diagnostic accuracy rate of ultrasound among 64 patients was 34.38%, of which 46.88% were misdiagnosed as fibroadenoma of breast, and the benign, borderline and malignant misdiagnosed as breast fibroadenoma respectively 55.56%, 50.00%, 10.00%. In the two-dimensional ultrasonic imaging, there were significant differences between patients with breast phyllodes tumors of different nature in the clearness of lesion boundary, cystic echo area, homogeneity of internal echo and hyperechoic septum (P<0.05), and there was no significant difference in the shape of the lesion, the diameter of the tumor, the presence of calcification and the enhancement of the posterior echo (P>0.05). 64 patients with phyllodes tumor of the breast showed different degrees of blood flow signals, and there was no significant difference in blood flow signal grading between patients with different tumors (P>0.05). Conclusion: Breast phyllodes tumors have some characteristics of ultrasonography. Whether there are small cystic anechoic areas and hyperechoic segregation within the tumors and whether the boundary of the tumors is clearly visible is an important basis for judging the benign and malignant of breast phyllodes tumors, suggesting that ultrasonography has a good application value in the clinical diagnosis of breast phyllodes tumors. 2019 Vol. 25 (7): 1170-1173 [Abstract] ( 130 ) HTML (1 KB)  PDF (1256 KB)  ( 298 ) 1174 MRI Study of Ischiofemoral Space after Femoral Head Collapse XING Qianchao, WANG Shenglin, QIU Hengzhi, et al DOI: 10.3969/j.issn.1006-6233.2019.07.032 Objective: To explore the changes of ischiofemoral space (IFS) and the relationship between ischiofemoral space with the quadratus femoris space(QFS), femoral offset (FO) and cervicodiaphyseal angle(CCD)after the collapse of the femoral head. Methods: The hip MRI images of 55 patients with unilateral femoral head necrosis (stage Ⅲ 31 cases,stage Ⅳ 24 cases ) were retrospectively analyzed.The bilateral IFS and QFS were measured on the cross section of T1WI,the bilateral FO and CCD were measured on the coronal section of T1WI,and observed the morphological and signal changes of the quadratus femoris muscle on the cross section of PDWI-FS. Result: s The IFS (1.76±0.14cm) , QFS(0.94±0.23cm), FO(2.78±0.27cm)in affected side were significantly lower than that in healthy side(2.19±0.19cm),(1.71±0.21cm), (3.83±0.22cm), the CCD(134.74±5.48°)in affected side significantly higher than that in healthy side (130.83±5.14°), the differences between the two groups were statistically significant (P＜0.05). The QFS, FO have positive correlation with IFS in the affected side(r＝0.757, 0.839, P＜0.05), while CCD have significant negative correlation with IFS in the affected side (r＝-0.680, P＜0.05). The IFS(1.81±0.20cm)、 QFS(0.99±0.26cm) and FO(2.84±0.27cm) in affected side of stage III patients were significantly higher than those of stage IV patients [IFS(1.71±0.14 cm), QFS (0.87±0.15 cm) and FO (2.69±0.26 cm)], while the CCD (133.17±5.10°) was lower than that of stage IV patients (136.77±5.38°), and there were significant differences between the two groups (P＜0.05). Conclusion: The IFS, QFS and FO decrease, while CCD increase after the collapse of the femoral head.The ischial femur impingement caused by the collapse of the femoral head may be involved in the occurrence of hip pain in patients with femoral head necrosis. 2019 Vol. 25 (7): 1174-1176 [Abstract] ( 122 ) HTML (1 KB)  PDF (1688 KB)  ( 417 ) 1177 Analysis of Anxiety and Depression in Elderly Patients with Hypertension Complicated with Lacunar Infarction WANG Jing, SUN Yanbao, LIU Yancheng, et al DOI: 10.3969/j.issn.1006-6233.2019.07.033 Objective: To explore the factor of anxiety and depression in hospitalized elderly hypertension patients combined with lacunar cerebral infarction. Methods: The Hamilton Anxiety Scale (HAMA-14 items) and Hamilton Depression Scale (HAMD-24 items) were used to assess the anxiety and depression status of 162 elderly patients with hypertension and lacunar infarction in Geriatrics Department of Chengde Central Hospital, and to analyze the influencing factors of anxiety and depression. Multivariate logistic regression was used to analyze the related risk factors. Results: The anxiety group and the depression group were compared with the control group, gender, smoking,and carotid plaque were statistically difference (P<0.05); diabetes, hyperlipidemia, hypoalbuminemia, frailty, and sleep quality were no statistical difference (P>0.05).The risk factors of anxiety included living hyperlipidemia (OR=2.799; 95% CI:1.180~6.638), hypoproteinemia (OR=11.271; 95% CI:1.269~10.084), frailty (OR=2.675; 95% CI:1.232~5.809), sleep disorder (OR=3.364; 95% CI:1.559~7.256). The risk factors of depression included living hyperlipidemia (OR=4.610; 95% CI:1.505~14.123), hypoproteinemia (OR=5.889; 95% CI:1.863~18.614), frailty (OR=4.024; 95% CI:1.674~9.672), sleep disorder (OR=17.405; 95% CI:6.847~44.243). Conclusions: Diabetes mellitus, hyperlipidemia, hypoproteinemia, weakness, sleep disorders in elderly hypertensive patients with lacunar infarction are more likely to develop anxiety and depression. 2019 Vol. 25 (7): 1177-1182 [Abstract] ( 133 ) HTML (1 KB)  PDF (1269 KB)  ( 374 ) 1183 Accuracy Comparison of Conventional Ultrasound and Elastography in Differential Diagnosis of Benign and Malignant Cervical Lymph Nodes JIANG Qun, et al DOI: 10.3969/j.issn.1006-6233.2019.07.034 Objective: To study the conventional ultrasound and ultrasound elastography in the benign and malignancy applied value in differential diagnosis of cervical lymph nodes. Methords: 84 patients (104 nodules) with cervical lymphadenopathy diagnosed by pathology in our hospital from June 2016 to June 2018 were selected as the research objects. The lymph node vascular pattern was classified by color Doppler ultrasound. Ultrasound elastography was used to analyze the difference of hardness between the lesion area and surrounding tissues. The clinical significance of each index in differentiating benign from malignant cervical lymph nodes was analyzed. The diagnostic results were based on pathological findings, and the diagnostic accuracy of the two methods was compared. Results: Pathological diagnosis showed that 23 (22.12%) of 104 cervical lymph nodes were benign and 81 (77.88%) were malignant; 80 (76.92%) were diagnosed accurately by Doppler ultrasonography; 85 (81.73%) were diagnosed accurately by ultrasound elastography. There was no significant difference between the accuracy of color Doppler ultrasonography and ultrasound elastography. Significance (P>0.05); and pathological diagnosis results were significantly different, P<0.05. Conclusions: Ultrasound elastography has a slightly higher accuracy and sensitivity in the differential diagnosis of benign and malignant cervical lymph nodes, while color Doppler ultrasound has a distinct advantage in specificity, so it can be complementary in the differential diagnosis of superficial lymph nodes. 2019 Vol. 25 (7): 1183-1185 [Abstract] ( 112 ) HTML (1 KB)  PDF (1223 KB)  ( 254 ) 1186 Clinical Observation of Fructonic Acid Combined with Collagen Dressing and CO2 Lattice Laser in the Treatment of Facial Acne Depressed Scar JIN Yanru, YANG Fan, LIU Xiaobing, et al DOI: 10.3969/j.issn.1006-6233.2019.07.035 Objective: To study the clinical curative effect of tartaric acid combined with collagen dressing and CO2 fractional laser (CO2FL)in the treatment of facial spitted acne scars. Methods: 98 patients with facial spitted acne scars treated in our hospital during the period from April 2016 to April 2017 were randomly divided into the study group (49 cases) and the control group (49 cases). The two groups were treated with CO2 fractional laser and collagen dressing, and the study group were additionally treated with tartaric acid. The curative effect, Vancouver scar scale (VSS) score, time of work delays and patient's satisfaction were compared between the two groups after 4 courses of treatment. Results: There were statistically significant differences in the interaction effects of between-groups and time points (P<0.05), and ECCA scores of two groups after treatment were lower than those before treatment (P<0.05). The total effective rate after treatment of the study group was significantly higher than that of the control group (97.96% vs 83.67%) (P<0.05). The difference of VSS score before and after treatment of the study group was significantly greater than that of the control group (P<0.05). After treatment, the total satisfaction rate of the study group was significantly higher than that of the control group (93.88% vs 75.51%) (P<0.05). The mean time of work delays of the study group was significantly shorter than that of the control group (P<0.05).The incidence rate of adverse reactions in the study group was significantly lower than that in the control group (24.48% vs8.16%) (P<0.05). Conclusion: Tartaric acid combined with collagen dressing and CO2FL is effective in the treatment of facial spitted acne scars. The regimen can effectively improve the scar status of patients and shorten the time of incapacity, with high safety. 2019 Vol. 25 (7): 1186-1189 [Abstract] ( 118 ) HTML (1 KB)  PDF (1254 KB)  ( 424 ) 1190 Study on the Risk Factors of Aortic Catheter Opening in Premature Infants with Hemodynamic Effects FANG Liang, GUAN Xianghong, ZHAO Li, et al DOI: 10.3969/j.issn.1006-6233.2019.07.036 Objective: To analyze the risk factors of hsPDA(hemodynamic significant PDA, hsPDA)and achieve the goal of early diagnosis and appropriate treatment to improve rate of survival. Methods: In January 2017-March 2018 hospitalized in our neonatal heart hospital, super PDA confirmed 140 cases of premature infants, using a retrospective survey method, through the literature, combined with the actual situation of the hospital, were the risk factors of the hemodynamic effects of hsPDA analysis. Results: HsPDA was related to gestational age, birth weight, sex, mother's pregnancy induced hypertension, premature rupture of membranes, placental lesions, amniotic fluid abnormalities, catheter diameter, 1.5-3mm, and fluid intake within 3 days after birth. Gestational age was associated with hsPDA (P<0.05). Birth weight was associated with hsPDA (P<0.05). Multivariate binary logistic regression analysis showed that sex, pregnancy induced hypertension, premature rupture of membranes, placental lesions and abnormal amniotic fluid were independent risk factors for hsPDA, with OR values of 1.173, 1.546, 1.670, 1.814 and 1.702, respectively. There was no correlation between maternal abnormal blood glucose metabolism during pregnancy, prenatal infection and prenatal dexamethasone use and hsPDA (P values were 0.6483, 0.343 and 0.410, respectively). Intrauterine distress (P = 0.8936) and umbilical cord abnormality (P = 0.3433) were not associated with hsPDA. The diameter of PDA catheter ranged from 1.5 mm to 3 mm, which was associated with hsPDA (P<0.05). The diameter of PDA catheter ranged from 1.6 mm to 3 mm, which was associated with hsPDA (P<0.05). The diameter of catheter > 3mm was not associated with hsPDA (P=0.9598). The liquid intake of PDA in hsPDA group and nhsPDA group on the 3rd day after birth was examined by t test. The results showed that the liquid intake on the 1st day (P<0.001), the 2nd day (P<0.001), and the 3rd day (P<0.001) were all correlated with hsPDA (P<0.05). Conclusions: Identifying and avoiding the risk factors of hsPDA is of great significance for improving the survival rate of premature infants and reducing the occurrence of sequelae. 2019 Vol. 25 (7): 1190-1193 [Abstract] ( 96 ) HTML (1 KB)  PDF (1263 KB)  ( 311 ) 1194 Effect of Laparoscopic-assisted Vaginal Hysterectomy on Perioperative Parameters and Long-term Pelvic Floor Function in Patients with Cervical Carcinoma in situ LI Yue, YE Liu DOI: 10.3969/j.issn.1006-6233.2019.07.037 Objective: To investigate the effect of laparoscopic assisted vaginal hysterectomy on perioperative indexes and long term pelvic floor function in patients with carcinoma in situ of cervix. Methods: 120 patients with carcinoma in situ of cervix, treated in our hospital from June 2014 to June 2017, were randomly divided into experimental group (n=60) and control group (n = 60). 60 patients of the control group were treated with abdominal panhysterectomy, and 60 patients of the experimental group were treated with laparoscopic-assisted vaginal hysterectomy;all patients were followed up for 12 months.The perioperative indexes and pelvic floor function of the two groups were observed. Result: Compared with the control group, the operation time (t =2.579,P=0.011), postoperative exhaust time (t =1.994,P=0.048) ,anti- infective therapy time (t =5.234,P<0.001), ambulation time (t =8.678,P<0.001), hospitalization time (t =9.610,P<0.001)of the patients in the experimental group were significantly shorter, and intraoperative blood loss (t =11.343,P<0.001) was significantly lower, the differences were statistically significant.In addition, the incidence of postoperative complications in the experimental group was 1.67% (1/60), significantly lower than 16.67% (10/60) of the control group, the difference was statistically significant (χ2=8.107, P=0.004).The degree of pain in the experimental group was significantly lower than that in the control group, the difference was significant (P<0. 05). The patients with poor quality of life and stress urinary incontinence were more than preoperative in two groups(P<0.05). There was no significant difference between the two groups in the pelvic floor function after the operation for 6 months and 12 months. Conclusion: Laparoscopic assisted vaginal hysterectomy for the treatment of carcinoma in situ of cervix with low intraoperative blood loss, fast recovery,less postoperative complications and less pain; but it could affect the pelvic floor function after operation. 2019 Vol. 25 (7): 1194-1197 [Abstract] ( 140 ) HTML (1 KB)  PDF (1272 KB)  ( 196 ) 1198 Risk Factors and Outcomes of Infectious Pancreatic Necrosis in Patients with Severe Acute Pancreatitis LIU Yan, WANG Chunhui, ZHANG Mingguang, et al DOI: 10.3969/j.issn.1006-6233.2019.07.038 Objective: To study the risk factors of infective pancreatic necrosis in patients with severe acute pancreatitis (SAP) and to explore their effects on prognosis. Methods: The clinical data of 319 patients with SAP in our hospital were retrospectively analyzed. According to whether pancreatic infection occurred, they were divided into infection group (n=62) and non-infection group (n=257). Clinical data of basic information, etiology, disease course, symptoms and signs, occurrence of complications, laboratory results, organ system function score and corresponding treatment measures were collected in the two group and compared and analyzed. The treatment effects of the two groups were followed up, and the condition changes and prognosis were compared between the two groups. Results: Among 319 patients with SAP, 62 cases (19.44%) were complicated with pancreatic infection, and the univariate analysis showed that there were statistically significant differences in the disease course, hypoxemia, MOF, extra-pancreatic infection, WBC, CRP, APACHE II score, fasting time and mechanical ventilation and antibiotic application between infection group and non-infection group (P<0.05). Logistic regression analysis showed that the disease course, hypoxemia, MOF, extra-pancreatic infection, fasting time and mechanical ventilation were independent risk factors for pancreatic infection in SAP (P<0.05), and antibiotic applicationwasan effective protective factor (P<0.05). The case mortality of infection group and non-infection group were 25.81% and 4.28% respectively(P<0.05). Conclusions: SAP complicated with infectiouspancreatic necrosis can significantly increase the mortality risk of patients. And its independent risk factors include disease course, hypoxemia, MOF, extra-pancreatic infection, fasting time and mechanical ventilation, and its protective factor is preventive application of antibiotics. 2019 Vol. 25 (7): 1198-1201 [Abstract] ( 167 ) HTML (1 KB)  PDF (1254 KB)  ( 227 ) 1202 Clinical Review and Analysis of Complications of Bronchoscopy in Children LUO Xinbin, BAO Qiong,WANG Shasha, et al DOI: 10.3969/j.issn.1006-6233.2019.07.039 Objective: The complications occurred during and after bronchoscopy in children were reviewed and analyzed. Method: From January 2016 to January 2019, 312 children aged 0-14 who underwent electronic bronchoscopy in our hospital were selected to record the intraoperative and postoperative complications. Results: A total of 347 bronchoscopy examinations were recorded in the medical records of 312 children.During and after the operation, a total of 48 cases of complications were recorded, including 36 cases of general complications (19 cases during the operation and 17 cases after the operation) and 12 cases of serious complications (10 cases during the operation and 2 cases after the operation). The incidence of general complications was 11.54% and the incidence of serious complications was 5.47%.Hypoxemia was the most common complication, with a total of 16 cases (3.85%).Postoperative fever and intraoperative bleeding are also common complications. Conclusion: Because of the particularity of children's physiology and anatomy, the incidence of complications of bronchoscopy is higher than that of adults. The safety of operation should be improved by strictly grasping the indication of bronchoscopy, perfecting preoperative examination and skilled operation. 2019 Vol. 25 (7): 1202-1204 [Abstract] ( 121 ) HTML (1 KB)  PDF (1236 KB)  ( 205 ) 1205 Clinical Value of Ambulatory Electroencephalogram and Video Electroencephalogram in the Diagnosis of Non-convulsive Seizures in Children WU Xiaobo, CHEN Zhao, LIU Wei, et al DOI: 10.3969/j.issn.1006-6233.2019.07.040 Objective: To study the diagnostic value of ambulatory electroencephalogram (AEEG) and video electroencephalogram (VEEG) in children with non-convulsive seizures (NCS). Methods: 82 patients diagnosed as NCS in our hospital from January 2016 to January 2018 were included in the study and given retrospective analysis. All patients were given routine electroencephalogram (REEG), and 56 patients were given 24h AEEG, and 78 patients were given VEEG. Diagnostic value of 24hAEEG and VEEG in NCS was analyzed. Results: 56 children patients were given 24h AEEG examination, and the abnormal discharge rate, epileptic discharge rate and detection rate of clinical seizures were significantly higher than those of REEG (P<0.05). 78 children patients were given VEEG examination, among which 59 cases were with seizure events and 6 cases were with abnormal discharge during seizure, and 57 cases were finally confirmed by combining with past history, family history and neurological examination of children patients. And the seizure events rate and abnormal discharge rate during seizure of VEEG were significantly higher than those of REEG (P<0.05). VEEG suggested that all children patients had somatic NCS seizures, among which 50 cases (87.72%) were non-convulsive tonic seizures and the remaining 7 cases (12.28%) were benign myoclonus. Conclusions: Compared with REEG, 24hAEEG can effectively prolong the monitoring time and increase the positive rate of capture events, but the examination results are greatly disturbed by the activities of children patients or parents, and VEEG achieves the simultaneous recording of electroencephalogram and seizure status, and it has highest diagnostic value. 2019 Vol. 25 (7): 1205-1207 [Abstract] ( 124 ) HTML (1 KB)  PDF (1247 KB)  ( 285 ) 1208 Effects of Intravenous Anesthesia with Etomidate and Propofol on Cerebral Oxygen Metabolism in Patients with Subdural Hematoma ZHANG Changwei, et al DOI: 10.3969/j.issn.1006-6233.2019.07.041 Objective: To investigate the effects of intravenous anesthesia with etomidate and propofol on hematoma evacuation in patients with subdural hematoma. Methods: 86 patients with subdural hematoma from August 2016 to June 2018 were enrolled in our hospital, divided into etomidate group (n=43) and propofol group (n=43) as the simple random grouping and proceeded hematoma evacuation treatment. The propofol group was intravenously anesthetized with propofol, and the etomidate group was given intravenous anesthesia with etomidate. The two groups were analyzed before anesthesia induction (T0), after intubation (T1), 30 min (T2), and (T3) hemodynamics [mean arterial pressure (MAP), heart rate (HR)]. Cerebral oxygen metabolism index [CEO2, cervical internal venous oxygen saturation (SjvO2)] level, S100β protein level, lactic acid internal jugular venous lactic acid (Ljv), arterial blood lactate (La) level and adverse reactions incidence were compared. Results: Hemodynamics: There was no significant difference in MAP and HR levels between the two groups (P>0.05). The T1 and T3 were significantly lower in the propofol group than in the T0 period (P<0.05). T1, T2 There was no significant change in MAP and HR levels in the etomidate group compared with the T0 period (P>0.05), and the MAP in the propofol group was lower than that in the etomidate group at each time point after induction (P<0.05). Cerebral oxygen metabolism: There was no significant difference between CERO2 and SjvO2 levels in the T0 period (P>0.05). The levels of SjvO2 in the T1, T2 and T3 groups were higher than those in the T0 period, and the CERO2 level was lower than that in the T0 period, and the propofol group SjvO2 The level of CERO2 was lower than that of etomidate group (P<0.05). There was no significant difference between S100β protein levels in S100β protein:T0 period (P>0.05), T1, T2, T3 The levels of S100β protein in the two groups were higher than those in the T0 period, but the level of S100β protein in the propofol group was lower than that in the etomidate group (P<0.05). There was no significant difference in Ljv and La levels between the two groups during the T0 period. (P>0.05), there was no significant change in Ljv, La level and T0 period between T1, T2 and T3 (P>0.05). There was no significant difference between the groups (P>0.05); Adverse reactions: There was no significant difference between the incidence of adverse reactions in the propofol group (16.28%) and the etomidate group (11.63%) (P>0.05). Conclusions: Intravenous anesthesia with propofol and etomidate in patients with epidural hematoma during hematoma clearance can not lead to abnormal fluctuation of lactic acid level and has high safety, but etomidate has significant advantages in maintaining hemodynamic stability. Propofol can improve brain metabolism, protect brain and inhibit abnormal increase of S100beta protein level. 2019 Vol. 25 (7): 1208-1213 [Abstract] ( 131 ) HTML (1 KB)  PDF (1293 KB)  ( 215 ) 1214 Comparative Analysis of the Application of Self-made Puncture Apparatus in Thoracoscopic Surgery and Traditional Thoracotomy YANG Bin, ZHENG Xuan, SUN Jing, et al DOI: 10.3969/j.issn.1006-6233.2019.07.042 Objective: To study the application of self-made puncture device in thoracoscopic surgery and traditional thoracotomy. Methods: 88 patients with spontaneous pneumothorax who were hospitalized in our hospital from May 2012 to December 2015were divided into observation group (n = 44) and control group (n = 44). The patients in the control group were treated with traditional thoracotomy, the indexes and complications were compared between the two groups, and the patients were followed up to observe the recurrence after operation. Results: The volume of bleeding in the observation group was (61.81+9.31) mL, significantly lower than that in the control group [(90.23+15.83) mL, P<0.05]; the operation time was (71.1+12.89) min, significantly lower than that in the control group [(83.95+13.76) min, P<0.05]; the time of getting out of bed after operation was (23.16+7.32) h, significantly higher than that in the control group [(46.97+10.72) h, P<0.05]; The time was (6.82 + 1.22) days, which was significantly lower than that of the control group [(9.54 + 2.81) days, P<0.05]. The total incidence of complications in the observation group was significantly lower than that in the control group (χ2= 5.091, P<0.05); according to the follow-up results, the recurrence rate in the control group was significantly higher than that in the observation group (χ2= 3.106, P<0.05). Conclusion: The self-made puncture device is safe to be used in thoracoscopic surgery. Compared with traditional thoracotomy, it is simple to operate, and there are no serious complications in patients with minor surgical trauma,and significantly reduce the financial burden of the patient. 2019 Vol. 25 (7): 1214-1216 [Abstract] ( 117 ) HTML (1 KB)  PDF (1243 KB)  ( 213 ) 1217 Analysis on Influencing Factors of Short-term Outcomes during Hospitalization in Patients with Acute Myocardial Infarction YAO Kai, YU Guixia, ZHENG Xianmei DOI: 10.3969/j.issn.1006-6233.2019.07.043 Objective: To explore the influencing factors for recent outcomes during hospitalization in patients with acute myocardial infarction (AMI). Methods: 295 cases of patients with confirmed AMI from January 2016 to January 2017 were retrospectively analyzed. According to the disease outcomes during hospitalization, the patients were divided into good outcome (healing and improving) group and poor outcome (deterioration and death) group. The data of gender, age and treatment methods were recorded in the two groups, and Logistic regression analysis was performed on the patients' data. Results: Compared with good outcome group, the age, the time from onset to treatment, hospitalization heart rate and Killip classification were significantly increased in poor outcome group (P<0.05), and the proportions of patients combined with hypertension history, diabetes history, history of cardiovascular and cerebrovascular disease, and Killip classification≥grade III, ST-segment elevation myocardial infarction (STEMI) and drug-selective therapy were increased significantly (P<0.05), and the systolic blood pressure and diastolic blood pressure at admission were decreased significantly (P<0.05), and the proportions of patients with non-ST-segment elevation myocardial infarction (NSTEMI) and PCI were significantly decreased (P<0.05). Logistic regression analysis showed that age, time from onset to treatment, history of cardiovascular and cerebrovascular disease, myocardial infarction, Killip classification and PCI were all risk factors for prognosis in AMI patients during hospitalization. Conclusions: Age, time from onset to treatment, history of cardiovascular and cerebrovascular disease and Killip classification are independent risk factors for AMI, and PCI treatment is an independent protective factor for AMI. 2019 Vol. 25 (7): 1217-1220 [Abstract] ( 149 ) HTML (1 KB)  PDF (1250 KB)  ( 279 ) 1221 Effect of Discectomy via Iliac Crest Approach and Interlaminar Approach on Pain Function and Long-term Recurrence in Patients with L5S1 Disc Herniation ZHU Bin, et al DOI: 10.3969/j.issn.1006-6233.2019.07.044 Objective: To investigate the effects of discectomy via iliac crest approach and interlaminar approach on pain, function and long-term recurrence of L5~S1 disc herniation. Methods: From January 2014 to August 2016, 82 patients with lumbar disc herniation who were treated in our hospital were randomly divided into observation group (39 cases) and control group (43 cases). They were treated discectomy via iliac crest approach and intervertebral approach, respectively, both groups were followed up for 24 months. The operation conditions, pain before and after operation (VAS), motor function (ODI score), complications and long-term recurrence after surgery between the two groups were compared. Results: There was no significant difference in the time of postoperative ambulation and average hospitalization between the two groups (P=0.838, 0.169). The operation time, fluoroscopy times and intraoperative bleeding volume in the observation group were significantly higher than those in the control group (P=0.000, 0.000, 0.039). The VAS scores in the lumbar and leg and ODI scores of the two groups were significantly lower than those before operation (P<0.05), The VAS score of the observation group at 3 and 24 months after operation was lower than that of the control group (Pwaist=0.008, 0.002, Pleg = 0.006, 0.001). There was no significant difference in the ODI score between the two groups (P = 0.553, 0.202). There was no significant difference in the incidence of postoperative complications between the two groups (12.82% vs. 18.60%, P=0.474). The recurrence situation was not statistically significant between the two groups(HR=0.531,95%CI[0.107, 2.634], P=0.457). Conclusion: Discectomy via iliac crest approach can significantly relieve pain, restore the activity of patients, and the safety is guaranteed. However, the operation time and fluoroscopy times need to be further optimized. 2019 Vol. 25 (7): 1221-1225 [Abstract] ( 110 ) HTML (1 KB)  PDF (1261 KB)  ( 252 ) 1226 Clinical Efficacy of Self-made Qinggan Lishi Decoction in the treatment of Patients with Cervical Cancer Chemotherapy ZUO Minfang DOI: 10.3969/j.issn.1006-6233.2019.07.045 Objective: To study the clinical efficacy of self-made Qinggan Lishi decoction in the treatment of patients with cervical cancer chemotherapy. Methods: 86 patients with cervical cancer chemotherapy who were admitted to our hospital from January 2016 to July 2017 were randomly divided into control group (43 cases) and observation group (43 cases). Control group was given paclitaxel/irinotecan chemotherapy regimen, and observation group was given self-made Qinggan Lishi decoction on the basis of control group. After 6 w of treatment, the tumor diameter, time required for chemotherapy, treatment effects, serum tumor markers levels, immune function, quality of life and adverse reactions were evaluated and analyzed in the two groups. Results: The tumor diameter in observation group after treatment was significantly reduced, and the total effective rate of treatment was higher than that in control group (81.39% vs 72.09%) (P<0.05). The serum levels of carbohydrate antigen 125 (CA125), squamous cell carcinoma antigen (SCCA) and carcinoembryonic antigen (CEA) were significantly decreased in observation group after treatment (P<0.05). The levels of immunoglobulin G ((IgG), immunoglobulin M (IgM) and immunoglobulin A (IgA), blood CD3+ and CD4+ cell ratios and CD4+/CD8+ ratio in the blood were increased significantly in observation group (P<0.05). The SF-36 scores in observation group after treatment were significantly higher than those in control group (P<0.05), and the incidence rate of adverse reactions of grade II-III was significantly lower than that in control group (P<0.05). The local recurrence rate and distant metastasis rate within 1 year of treatment were 4.65% and 2.33% in observation group, which were lower than those in control group with 11.63% and 4.65% (P<0.05). Conclusions: Self-made Qinggan Lishi decoction can effectively improve the clinical treatment effects of patients with cervical cancer chemotherapy. 2019 Vol. 25 (7): 1226-1230 [Abstract] ( 150 ) HTML (1 KB)  PDF (1279 KB)  ( 194 )

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