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2019 Vol. 25, No. 3 Published: 2019-03-31 529 Role of miR-326 in LPS-induced Acute Lung Injury in Rats and Its Effect on NF-κB Signaling Pathway LIU Wenjuan, HUANG Aixia, LU Liwen DOI: 10.3969/j.issn.1006-6233.2019.03.001 Objective: To investigate the role of miR-326 in lipopolysaccharide (LPS)-induced acute lung injury in rats and its effect on Nuclear factor κB (NF-κB) signaling pathway. Methods: 20 adult female SD rats were divided into control group and model group according to the random number table method. The model group received intraperitoneal injection of LPS (10mg/kg) and the control group received intraperitoneal injection of normal saline. 6h later, all the animals were sacrificed under anesthesia, and the pulmonary tissue section was collected for wet/ dry weight ratio of lung tissue (W/D) calculation. Then the expression levels of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in lung tissues were measured by enzyme linked immunosorbent assay (ELISA), moreover, the real-time fluorescence polymerase chain reaction (RTFQ-PCR) was used to detect the expression levels of miR-326, nuclear factor-crythroid 2-related factor 2 (Nrf2) and NF-κB mRNA. Results: The lung tissue sections of the control group showed no obvious abnormalities, while that of the observation group was characterized by the exfoliative inflammatory cells and exudates in the bronchiolar bronchial cavity, capillary wall congestion, red cells in the alveolar cavity and interstitial, as well as thrombus formation. The W/D of the model group was higher than that of the control group (P<0.05); The experssion levels of IL-1β and TNF-α in lung tissue of the model group were significantly higher than those of the control group (P<0.05). The relative expression levels of miR-326, Nrf2 and NF-κB mRNA in the lung tissue of the model group were higher than those in the control group (P<0.05). Conclusion: The expression of microRNA-326 increased in LPS-induced acute lung injury rat model and increased the expression of inflammatory factors. Its mechanism may be related to the activation of NF-kappa B signaling pathway 2019 Vol. 25 (3): 529-532 [Abstract] ( 102 ) HTML (0 KB)  PDF (1417 KB)  ( 319 ) 533 Effect of Huachansu Capsule Combined with NX Chemotherapy on Serum Related Tumor Markers and Median Survival in Patients with Advanced Breast Cancer CHEN Hao DOI: 10.3969/j.issn.1006-6233.2019.03.002 Objective: To investigate the effect of Huachansu capsule combined with NX chemotherapy on serum-related tumor markers and median survival in patients with advanced breast cancer. Methods: From February 2014 to April 2016, 92 patients with advanced breast cancer were enrolled in our hospital. As the random number table method, they were divided into control group (n=46) and experimental group (n=46). The control group was given NX chemotherapy (capecitabine + vinorelbine). On this basis, the experimental group was given Huachansu capsule for 2 consecutive treatments. The therapeutic effects, adverse reactions, and Karnofsky functional status score (KPS) were observed in the two groups. Serum tumor markers [saccharide antigen 15-3 (CA153), carcinoembryonic antigen (CEA)] and metastasis-invasive indicators before and after treatment [matrix metal] Protease-9 (MMP-9), vascular endothelial growth factor (VEGF)], and two-year follow-up of the two groups of patients, the median survival (OS), median progression-free survival (PFS) were compared. Results: There was no significant difference between the RR group and the control group (P>0.05). The difference of serum CA153, CEA, VEGF and MMP-9 between the two groups was more significant than that of the control group (P<0.05); Both groups of adverse reactions were grade II-III. The incidence of thrombocytopenia, anemia, and neutropenia in the experimental group was lower than that in the control group (P<0.05). The improvement rate of KPS score in the experimental group was higher than that in the control group (P<0.05); After treatment During the 2-year follow-up, the median OS and median PFS in the experimental group were greater than those in the control group (P<0.05). Conclusion: Huachansu capsule combined with NX chemotherapy in the treatment of patients with advanced breast cancer is effective, can reduce adverse reactions, reduce serum CA153, CEA, VEGF, MMP-9 levels, improve quality of life, and prolong the survival of patients 2019 Vol. 25 (3): 533-536 [Abstract] ( 118 ) HTML (0 KB)  PDF (1232 KB)  ( 442 ) 537 Expression and Clinical Significance of GATA-6 and Dickkopf-1 in Pituitary Adenoma DIAO Yi, DONG Nan, YANG Yang, et al DOI: 10.3969/j.issn.1006-6233.2019.03.003 Objective: To investigate the expression of GATA-6 and Dickkopf-1 in pituitary adenomas and its clinical significance. Methods: 138 patients with pituitary adenomas were selected. The expressions of GATA-6 and Dickkopf-1 in pituitary adenomas and normal pituitary tissues were detected by real-time fluorescence reverse transcription and immunohistochemistry. The expression of GATA-6 and Dickkopf-1 in pituitary adenomas patients with different clinical features and the prognosis of pituitary adenomas with different levels of GATA-6 and Dickkopf-1 were analyzed. Results: The expression of Dickkopf-1 mRNA in pituitary adenoma group was lower than that in normal pituitary, and the expression of GATA-6 mRNA was higher than that in normal pituitary (P<0.01). The expression of Dickkopf-1 protein in pituitary adenoma group was lower than that in normal pituitary, and the expression of GATA-6 protein was higher than that in normal pituitary (P<0.01). The positive rate of Dickkopf-1 protein pituitary adenoma group was lower than that in normal pituitary gland, and the positive rate of GATA-6 protein pituitary adenoma group was higher than that in normal pituitary gland (P<0.01). The expression of Dickkopf-1 and GATA-6 protein was not significantly correlated with age (P>0.05). The expression of Dickkopf-1 and GATA-6 protein were significantly correlated with TNM stage, pathological grade, recurrence, depth of invasion, infiltration of vascular space, tumor maximum diameter and metastasis, and the higher TNM stage, pathological grade. The higher the credit stage, recurrence, depth of invasion, infiltration of vascular space, tumor diameter (>2cm), the lower the positive expression rate of Dickkopf-1 protein and the higher the positive expression rate of GATA-6 protein (P<0.01). The 3-year survival rate and survival time of Dickkopf-1 positive group were significantly higher than those of Dickkopf-1 negative group, and the 3-year survival rate and survival time of GATA-6 negative group were significantly higher than those of GATA-6 positive group (P<0.01). Conclusion: The expression of GATA-6 in pituitary adenomas is higher and the expression of Dickkopf-1 in pituitary adenomas is lower. GATA-6 play a promoting role in the course of occurrence and development of pituitary adenomas and Dickkopf-1 play a inhibiting role. The pituitary adenomas patients with high expression of Dickkopf-1 or low expression of GATA-6 can get better prognosis 2019 Vol. 25 (3): 537-541 [Abstract] ( 75 ) HTML (0 KB)  PDF (1249 KB)  ( 224 ) 542 Detection Value of Th Cell Level in Peripheral Blood in Hepatitis Cirrhosis and Hepatocellular Carcinoma CHEN Tian, et al DOI: 10.3969/j.issn.1006-6233.2019.03.004 Objective: To explore the detection value of peripheral blood Th cells in hepatitis, cirrhosis and liver cancer. Methods: 91 patients with liver diseases admitted by our department from March 2017 to March 2018 were selected as subjects, among which 34 were patients with chronic hepatitis b, 31 were patients with liver cirrhosis and 26 were patients with liver cancer. Meanwhile, 30 healthy subjects with normal liver function were selected as the control group. Using enzyme-linked immunosorbent (ELISA) method above and the control group in the peripheral blood of patients with Th cytokines - Th1 class factor [interferon (IFN) - gamma, interleukin (IL) - 12, tumor necrosis factor (TNF) - alpha], Th2 factor [IL - 4), IL - 6, IL - 10], the cells and the determination of Th cells (CD3 +, CD4 +, CD8 +). Results: IL-2, IFN-gamma, TNF-a, IL-4 and IL-10 in hepatitis B group were higher than those in cirrhosis group, while IL-6 was lower than that in cirrhosis group (P<0.05). The levels of IL-12, IL-6 and IL-10 in the hepatitis b group were higher than those in the liver cancer group, while the levels of ifn-fractionation and TNF- were significantly lower than those in the liver cancer group (P<0.05). The levels of ifn-beta, TNF-, IL-4 and IL-10 in the liver cirrhosis group were lower than those in the liver cancer group and IL-6 was higher than those in the liver cancer group, with statistically significant differences (P<0.05). IL-12, ifn-beta, TNF-, IL-4, IL-6, and IL-10 in the hepatitis b group and the cirrhosis group were lower than those in the control group, with statistically significant differences (P<0.05). IL-12, ifn-fractionation, IL-4, IL-6, and IL-10 in the liver cancer group were all lower than those in the control group, with statistically significant differences (P<0.05). There were also statistically significant differences in CD3+, CD4+, CD8+ and CD4+/CD8+ between the hepatitis B group, the liver cirrhosis group and the liver cancer group (P<0.05). Conclusion: The expression of Th1 and Th2 cytokines is abnormal in patients with hepatitis, cirrhosis and hepatocellular carcinoma. The balance of Th1/Th2 is destroyed and the clearance of HBV virus is inhibited. The detection of Th1/Th2 cytokines in patients with hepatitis, cirrhosis and hepatocellular carcinoma should be emphasized 2019 Vol. 25 (3): 542-547 [Abstract] ( 72 ) HTML (0 KB)  PDF (1351 KB)  ( 195 ) 548 Diagnostic Value of Doppler Imaging Combined with High Frequency Ultrasound in Surface Soft Tissue Masses DONG Ruiyu, QIAN Yonghuan, HE Qixiu DOI: 10.3969/j.issn.1006-6233.2019.03.005 Objective: To explore the diagnostic value of doppler imaging combined with high frequency ultrasound in soft tissue mass on the surface of body. Methods: 97 patients with soft tissue mass on the surface of body who had pathological diagnosis were enrolled to this study from March 2017 to March 2018. The soft tissue mass were evaluated by doppler imaging combined with high frequency ultrasound, meanwhile, the blood flow classification were compared between benign and malignant. Results: A total of 90 cases were detected by high frequency Doppler ultrasound in 97 patients. The diagnostic coincidence rate was 92.78% (90/97), of which 85 cases were benign and 5 cases were malignant, and the missed diagnosis rate was 7.23% (7/97). In CDFI blood flow grading, benign tumors were mainly grade 0 and grade I blood flow distribution, while malignant tumors were mainly grade II-IV blood flow distribution. The proportion of benign tumors in grade 0 and grade I was 91.30% and 6.52% more than malignant tumors. The proportion of grade III and grade IV tumors was 1.09% and 0.00% less than malignant tumors (P<0.01), and PSV (16.71+2.97) cm/s and RI (63.11+12.12)% were lower than malignant tumors (P<0.01). Conclusion: The clinical value of Doppler imaging combined with high frequency ultrasound in qualitative diagnosis of soft tissue masses on the surface of the body is remarkable. It can clearly show the characteristics of the internal ultrasound of the masses, help to judge the type of the masses, and the coincidence rate of differential diagnosis between benign and malignant masses is high, so it can be used as the first choice for qualitative diagnosis 2019 Vol. 25 (3): 548-550 [Abstract] ( 76 ) HTML (0 KB)  PDF (1214 KB)  ( 253 ) 551 Effect of Combined Treatment of Pulmonary Surfactant and Non-invasive High Frequency Oscillatory Ventilation on Neonatal Respiratory Distress Syndrome FENG Aimin, XIE Xiuchun, WANG Miao, et al DOI: 10.3969/j.issn.1006-6233.2019.03.006 Objective: To observe the efficacy of combined treatment of pulmonary surfactant and non-invasive high-frequency oscillatory ventilation in neonatal respiratory distress syndrome (NRDS). Methods: 80 cases of children patients with NRDS admitted to our hospital from May 2017 to April 2018 were selected for the study and were randomly divided into observation group and control group according to the random number table method, with 40 cases in each group. Control group was given conventional ventilation combined with pulmonary surfactant, and observation group was treated with non-invasive high-frequency oscillatory ventilation combined with pulmonary surfactant. The effective rate of treatment, general conditions and arterial blood gas indexes [arterial partial pressure of oxygen (PaO2), pH value, partial pressure of carbon dioxide (PaCO2), percentage of inhaled oxygen concentration (FiO2), oxygenation index (OI)] and the incidence rate of complications were recorded in the two groups. Results: The effective rate of treatment in observation group was higher than that in the control group (90.00% vs 70.00%) (P<0.05). The operative time, symptom relief time and hospital stay in observation group were shorter than those in control group (P<0.05), and there was no significant difference in intermittent forced ventilation time and survival rate between the two groups (P>0.05). The PaO2 and pH value in observation group at 24h of embarkation were higher than those in control group while the PaCO2, FiO2 and OI were lower than those in control group (P<0.05). There were no significant differences in the incidence rate of complications (pneumothorax, pulmonary hemorrhage, bronchopulmonary dysplasia, pneumonia) between the two groups (P>0.05). Conclusions: The combined treatment of pulmonary surfactant and non-invasive high frequency oscillatory ventilation in children with NRDS can significantly improve the curative effect, shorten the time of going on the machine and hospitalization, and effectively improve the arterial blood gas index without significantly increasing complications, which is worthy of clinical application 2019 Vol. 25 (3): 551-554 [Abstract] ( 108 ) HTML (0 KB)  PDF (1233 KB)  ( 280 ) 555 Different Surgical Treatments on Vision Intraocular Pressure Astigmatism and complications in Patients with Glaucoma complicated with Cataract HE Xin, LIU Ning DOI: 10.3969/j.issn.1006-6233.2019.03.007 Objective: To compare the effects of phacoemulsification (Phaco) combined with trabeculectomy and Phaco combined with goniosynechialysis on vision, intraocular pressure, astigmatism and complications in patients with glaucoma complicated with cataract. Methods: 94 patients with glaucoma and cataract admitted in our hospital from March 2016 to March 2018 were collected. Among them, 49 patients were treated with Phaco combined with trabeculectomy (trabeculectomy group), 45 patients were treated with Phaco combined goniosynechialysis (goniosynechialysis group). The vision improvement, intraocular pressure, anterior chamber depth, anterior chamber angle, astigmatism and complications in the two groups 6 months after surgery were compared. Results: At 6 months after operation, there was no significant difference in visual acuity improvement rate between the two groups (77.55% vs 84.44%) (P>0.05). At 6 months after operation, there was no significant difference in the decrease degree of intraocular pressure and increase degree of anterior chamber depth between the two groups (P>0.05). However, the increase of anterior chamber angle in the goniosynechialysis group was significantly greater than that in the trabeculectomy group (P<0.05). At 6 months after operation, the increase degree of astigmatism and the incidence of complications in the goniosynechialysis group were significantly lower tha those in the trabeculectomy group (P<0.05). Conclusion: Compared with Phaco combined with trabeculectomy, Phaco combined with angle separation has lower astigmatism and fewer complications in the treatment of glaucoma combined with cataract 2019 Vol. 25 (3): 555-558 [Abstract] ( 112 ) HTML (0 KB)  PDF (1223 KB)  ( 268 ) 559 Application of Vertical Spinal Muscle Planar Block Combined with Laryngeal Mask Retention for Autonomous Breathing in Thoracoscopic Lung Lobectomy Anesthesia HU Liqun, LI Li, FU Jinsong, et al DOI: 10.3969/j.issn.1006-6233.2019.03.008 Objective:To investigate the efficacy and safety of spinal plane block combined with laryngeal mask self-help breathing in anesthesia for thoracoscopic pulmonary lobectomy. Methods:40 cases of patients with elective thoracoscopic lobectomy in our hospital were selected and randomly divided into the erector spine plane block combined with the laryngeal mask and retained spontaneous breathing anesthesia group(group C) and the double-lumen endotracheal intubation general anesthesia group (group S) with 20 in each.The concentration levels of plasma cortisol,norepinephrine and epinephrine were measured in the two groups before anesthesia induction (T1),10 minutes after the beginning of operation (T2),30 minutes after the beginning of operation (T3) and 10 minutes after the end of operation (T4);The highest PetCO2 (PetCO2max) and the lowest SpO2 (SpO2min) were recorded during surgery in the two groups;The operative time,anesthesia recovery time,hospitalization time,postoperative complications,postoperative VAS pain and surgeon's satisfaction were compared between the two groups.Results:Compared with T1, the levels of cortisol, norepinephrine and epinephrine at T2, T3 and T4 in both groups increased (P<0.05). At T2, T3 and T4, the contents of cortisol, norepinephrine and epinephrine in group C were lower than those in group S at the same time point (P<0.05). Compared with group S,patients in group C experienced increased PetCO2max (P<0.05),decreased SpO2min (P<0.05),shortened anesthesia recovery time and hospitalization time (P<0.05), decreased postoperative VAS pain score (P<0.05),and significantly decreased the incidence of postoperative laryngopharyngeal pain and hoarseness (P<0.05).There was no difference in operative time and surgeon's satisfaction between the two groups (P>0.05).Conclusion: The erector spinae plane block combined with laryngeal mask and retained spontaneous breathing in anesthesia is certain feasible for thoracoscopic lobectomy,which does not affects the surgical process and effectively inhibits the surgical stress response,accelerates patient recovery and reduces complications. 2019 Vol. 25 (3): 559-562 [Abstract] ( 109 ) HTML (0 KB)  PDF (1230 KB)  ( 371 ) 563 Effects of Different Analgesic Regimens on Postoperative Analgesia and Immune Function in Patients with Cancer HUO Miao, ZHANG Qian, et al DOI: 10.3969/j.issn.1006-6233.2019.03.009 Objective: To study the effects of different analgesic regimens on postoperative analgesia and immune function in patients with cancer. Methods: 120 cases of tumor patients admitted to our hospital for surgery from January 2015 to January 2018 were included in the study and were divided into the following four groups according to simple random grouping method, including group A (sufentanil + dezocine + ondansetron, n=30), group B (suffentanil + NSAIDS + ondansetron, n=30), group C (dezocine+ NSAIDS + ondansetron, n=30) and group D (sufentanil + dezocine + NSAIDS + ondansetron, n=30). The postoperative analgesic effects and body immune function were counted among the four groups. Results: At each time point after operation, the VAS scores in resting and coughing status in group D were significantly lower than those in the other three groups (P<0.05). The frequency of intravenous analgesia (PCIA) compression in group D at each time point was less than that in the other three groups (P<0.05). There were no interactions between CD3+, CD4+, CD8+ and CD4+/CD8+ at each time point among the four groups, and there were interactions in the number of NK cells among the four groups at each time point (P<0.05), and the number of NK cells in groups B and C after operation was decreased, and there was significant difference at different time points within-groups (P<0.05), and there was no significant difference between groups B and group D at each time point (P>0.05). There was a significant difference in the adverse reactions rate among the four groups after operation (P<0.05), and there were significant differences in adverse reactions between group A and group B, between group B and group C and between group B and group D (P<0.05). Conclusions: Sufentanil + dezocine + non-steroidal anti-inflammatory drugs (NSAIDS) + ondansetron can effectively control postoperative pain in patients with cancer, reduce the immunosuppression caused by postoperative pain, and reduce the amount of anesthetic drugs, and it has high safety and is worthy of clinical promotion. 2019 Vol. 25 (3): 563-567 [Abstract] ( 123 ) HTML (0 KB)  PDF (1239 KB)  ( 228 ) 568 Protective Effect of Angelica Polysaccharides on Energy Metabolism Disorder of H9c2 Myocardial Cells Induced by Hypoxia-reoxygenation Injury HUO Lichao, LI Mengli, QIAO Chengdong DOI: 10.3969/j.issn.1006-6233.2019.03.010 Objective: To explore the protective effect of Angelica polysaccharide (ASP) on energy metabolism disorder of H9c2 myocardial cells induced by hypoxia-reoxygenation damage. Methods: MTT was used to detect the effect of polysaccharides from Angelica sinensis on the proliferation of H9c2 cells. The hypoxia-reoxygenation model of Angelica sinensis polysaccharide intervention and non-intervention was constructed in vitro; cell morphology was observed; apoptosis was detected by flow cytometry; mitochondrial membrane potential detection kit was used to detect cells. Mitochondrial membrane potential changes; kits were used to detect the activity of Na+-K+ATPase and Ca2+-Mg2+ATPase and mitochondrial respiratory enzyme chain complex I and IV in LDH and cardiomyocytes in culture supernatant of cardiomyocytes. Results: Angelica polysaccharide inhibited the proliferation of H9c2 cells in a concentration-dependent manner. Hypoxia-reoxygenation induced apoptosis of H9c2 cells, decreased mitochondrial membrane potential, and increased LDH in H9c2 cell supernatant. Na+-K+ATPase and Ca2+-Mg2+ATPase in cells and mitochondrial respiratory enzyme chain complex I, IV activity decreased; Angelica polysaccharide can inhibit cell apoptosis in a concentration-dependent manner, increase mitochondrial membrane potential, reduce LDH in supernatant, increase Na+-K+ATPase, Ca2+-Mg2+ATPase and mitochondrial respiratory enzyme chain complex I, IV activity. Conclusion: Angelica polysaccharide can protect cardiomyocytes from hypoxia-reoxygenation injury by improving myocardial cell energy metabolism disorder caused by hypoxia-reoxygenation. 2019 Vol. 25 (3): 568-571 [Abstract] ( 86 ) HTML (0 KB)  PDF (1821 KB)  ( 234 ) 572 Effect of Probiotic Enteral Nutrition Intervention on Intestinal Flora and Inflammatory State in Patients with Severe Cerebral Hemorrhage after Operation LI Yuanyuan, Yanruiying, LI Dongchun, et al DOI: 10.3969/j.issn.1006-6233.2019.03.011 Objective: To explore the effect of enteral nutrition intervention with probiotics on intestinal flora and inflammatory status after critical cerebral hemorrhage surgery. Methods:86 cases of patients after critical cerebral hemorrhage surgery from January 2016 to January 2018 were divided into observation group and control group according to the simple random grouping, with 43 cases in each group. Control group was given gastric intubation of enteral nutrition intervention on the basis of conventional treatment, and observation group was supplemented with probiotics on the basis of control group. Nutritional status [serum total protein (TP), albumin (ALB), hemoglobin (HB)], intestinal flora distribution (Bifidobacterium, Lactobacillus, Enterobacter, Enterococcus), immune function (T lymphocyte subsets) and inflammatory status [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8)] were evaluated in the two groups before intervention and after 2 weeks of intervention. And the incidence rate of adverse events was compared between the two groups. Results:Before intervention, there were no significant differences in the levels of TP, ALB and HB between the two groups (P>0.05). Before intervention, there were no significant differences in the levels of TNF-α, IL-6 and IL-8 between the two groups (P>0.05). After 2w intervention, the levels of TP, ALB and HB in the two groups were higher than those before intervention (P<0.05) while the levels of TNF-α, IL-6 and IL-8 were lower than those before intervention (P<0.05), and the changes in observation group were greater than those in control group (P<0.05). Before intervention, there were no significant differences between the two groups in Bifidobacterium, Lactobacillus, Enterobacter and Enterococcus (P>0.05). After 2w of intervention, the Bifidobacterium and Lactobacillus in observation group were higher than those before intervention and those in control group at the same time period (P<0.05), and the Enterobacter and Enterococcus were lower than those before intervention and those in control group at the same time period (P<0.05). There was no statistically significant difference in the Bifidobacterium and Lactobacillus in control group compared with those before intervention (P>0.05). The Enterobacter and Enterococcus in control group were higher than those before intervention (P<0.05). Before intervention, there were no significant differences in CD3+, CD4+ and CD4+/CD8+ between the two groups (P>0.05). After 2w of intervention, the levels of CD3+, CD4+ and CD4+/CD8+ in the two groups were higher than those before intervention (P<0.05), and the increase in observation group was greater than that in control group (P<0.05). The CD8+ in observation group was lower than that before intervention and that in control group at the same time period (P<0.05). There was no significant difference in CD8+ before and after intervention in control group (P>0.05). The incidence rates of gastrointestinal hemorrhage and intestinal flora imbalance in observation group were lower than those in control group (P<0.05). There was no statistically significant difference in the incidence rate of pulmonary infection (P>0.05). Conclusions:Probiotic enteral nutrition intervention can improve nutritional status, intestinal flora, inflammatory status and immune function of patients with severe cerebral hemorrhage after operation, and reduce the risk of complications. 2019 Vol. 25 (3): 572-576 [Abstract] ( 170 ) HTML (0 KB)  PDF (1245 KB)  ( 304 ) 577 Clinical Significance of Detection of Parathyroid Hormone and Homocysteine in Patients with Chronic Kidney Disease LIU Hong, JIN Juan, ZHOU Zhifeng, et al DOI: 10.3969/j.issn.1006-6233.2019.03.012 Objective: To explore the clinical significance of the detection of PTH and Hcy in patients with the chronic kidney disease. Methods: 48 patients with chronic kidney disease (CKD) were divided into three groups: CKD stage 3, CKD stage 4 and CKD stage 5 according to the clinical diagnosis. PTH, Cys C, Hcy and Cr were detected in three groups, and the statistical analysis was conducted. Results: The levels of serum PTH, Cys C, Hcy and Cr in CKD stage 5 group were higher than those in CKD stage 4 and CKD stage 3 groups, the difference was statistically significant (P<0.05), but there was no significant difference between CKD stage 4 group and CKD stage 3 group in serum PTH, Cys C , Hcy and Cr levels (P>0.05 ). The positive rates of PTH in CKD stage 5 group, CKD stage 4 group and CKD stage 3 group were: 70.8%, 21.4%, 20%; The positive rates of Hcy in CKD stage 5 group, CKD stage 4 group and CKD stage 3 group were: 58.3%, 7.1%, 10% . PTH,Hcy,Cr and Cys C were positively correlated(R=0.505、0.855、0.788). Conclusion: The combined detection of PTH, Hcy and other indicators is helpful for the diagnosis and judgment of CKD patients, and provides accurate guidance for clinical diagnosis and treatment. 2019 Vol. 25 (3): 577-579 [Abstract] ( 102 ) HTML (0 KB)  PDF (1214 KB)  ( 198 ) 580 Changes and Clinical Significance of Serum CXCL16, GDF15, Lp-PLA2 Levels in Patients with Acute Cerebral Infarction LIU Xiqi, et al DOI: 10.3969/j.issn.1006-6233.2019.03.013 Objective: To investigate the expression levels of serum CXCL16, GDF15 and Lp-PLA2 in patients with acute cerebral infarction (ACI) and its clinical significance. Methods: 100 patients with acute cerebral infarction (study group) and 100 healthy subjects (control group) were enrolled in our hospital from January 2016 to March 2018. The clinical data of patients were collected and ACI patients were performed according to TOAST. Grouping. The levels of CXCL16, GDF-15 and Lp-PLA2 in the serum of patients were detected by enzyme-linked immunosorbent assay and statistical analysis was performed. Results: Univariate analysis showed that there was a significant difference in the levels of hypertension, diabetes, hyperlipidemia, CXCL16, GDF15 and Lp-PLA2 between the ACI group and the control group (P<0.05). Serum CXCL16 levels in ACI patients were associated with BMI (P=0.001), hypertension (P=0.018), hyperlipidemia (P=0.044), and NIHSS score at admission (P=0.004); GDF15 and diabetes (P=0.042) Hyperlipidemia (P=0.005) and NIHSS score (P=0.003) at admission; Lp-PLA2 and BMI (P=0.046), hyperlipidemia (P=0.040), and NIHSS score at admission (P=0.046) related. Compared with other ACI subtypes, patients with large atherosclerosis (LAA) had the highest levels of serum CXCL16, GDF15, and Lp-PLA2 (3.64±0.63, 1338.12±513.31, 344.52±134.26, respectively), and there were statistical differences (P<0.05). Conclusion: The elevated levels of serum CXCL16, GDF-15 and Lp-PLA2 are risk factors for acute ischemic stroke. 2019 Vol. 25 (3): 580-583 [Abstract] ( 130 ) HTML (0 KB)  PDF (1233 KB)  ( 268 ) 584 CT and MRI Imaging Findings of Patients with Hypopharyngeal Carcinoma and Their Comparison with Pathological Features LU Kaiwen, QI Xiaohu, et al DOI: 10.3969/j.issn.1006-6233.2019.03.014 Objective:To analyze the CT and MRI imaging findings of patients with hypopharyngeal carcinoma and their comparison with pathological features. Methods:The clinical data of 34 patients with hypopharyngeal carcinoma admitted to our Department of Otorhinolaryngology from March 2016 to March 2018 were retrospectively analyzed. All patients were given CT and MRI before treatment. Various signs on the images were observed and recorded, and the results of histological pathology were taken as standards to compare the tumor staging of CT and MRI and the imaging conditions of surrounding tissue structure of tumor involvement. Results:There were 28 cases (82.35%) with the same tumor stage and pathological stage of CT, and there were 30 cases (88.24%) with the same tumor stage and pathological stage of MRI, and there was no significant difference in the coincidence rate of tumor staging of two imaging methods (P>0.05). The results of pathological examination were taken as the standards, and there were no statistically significant differences in the detection rates of invasion of paralaryngeal space, cricoid cartilage, thyroid cartilage, preepiglottic space,arytenoid cartilage and lymph node metastasis by CT and MRI (P>0.05). The detection rate of intramural adipose layer of posterior annulus by MRI was higher than that by CT (P<0.05). Conclusions:CT and MRI both have high accuracy in staging of hypopharyngeal carcinoma, and there is no significant difference in imaging conditions of surrounding tissues of tumor invasion. However, MRI has an advantage in the imaging of intramural adipose layer of posterior annulus. 2019 Vol. 25 (3): 584-587 [Abstract] ( 119 ) HTML (0 KB)  PDF (1235 KB)  ( 379 ) 588 Clinical Value of Serum igf-1 Vitamin A 25-(OH)D Levels in Short Stature Child LIU Xin, JIANG Huiyun, LIANG Yanting, et al DOI: 10.3969/j.issn.1006-6233.2019.03.015 Objective: To explore the clinical value of serum insulin growth-like factor-1 (IGF-1), vitamin A and 25-hydroxyvitamin D (25-(OH)D) levels in short stature children. Methods: 146 cases of short stature children who treated from January 2015 to May 2015 in our hospital, at the same time 109 cases height of normal healthy children as control group. Then serum levels of IGF-1, vitamin A, 25-(OH)D of all the subjects were compared, and the changes in the above indicators before and after treatment, the predictive value of ROC curve analysis indicators was obtained. Results: IGF-1, vitamin A, 25-(OH)D and height in short stature children group were lower than those in the control group (P<0.05). IGF-1, vitamin A, 25-(OH)D and height in children with short stature after treatment were higher than before treatment (P<0.05). serum IGF-1 area under the curve was 0.722, sensitive and specific degree were 0.696 and 0.706 , the area under the curve of vitamin A was 0.712, sensitive and specific degree were 0.697 and 0.691 , the area under the curve of 25-(OH) D was 0.705, sensitive and specific degree were 0.913 and 0.411, the joint detection sensitivity and specific area under the curve was 0.824, the degree of 0.783 and 0.794, under the joint detection curve area significantly higher than that of single index. Conclusion: Serum IGF-1, vitamin A and 25-(OH)D can be used as effective indicators for the screening and diagnosis of children with short stature, Appropriate intervention is recommended for children with short stature, to improve adult life 2019 Vol. 25 (3): 588-591 [Abstract] ( 121 ) HTML (0 KB)  PDF (1338 KB)  ( 277 ) 592 Analysis of miR-21 Expression in Gingival Crevicular Fluid and the Correlation with MMP-9 Levels in Patients with Aggressive Periodontitis WU Lina, et al DOI: 10.3969/j.issn.1006-6233.2019.03.016 Objective: To investigate the miR-21 expression levels in gingival crevicular fluid and its correlation with MMP-9 levels in patients with aggressive periodontitis. Methods: 89 cases of aggressive periodontitis (case group) and 78 cases of health individuals in our hospital (control group) were selected. Then various indicators were detected, including expression levels of microRNA-21 and MMP-9 in gingival crevicular fluid, the plaque index, probing depth, clinical attachment loss and bleeding index. Results: The plaque index, probing depth, clinical attachment loss and bleeding index of the case group were higher than those of the control group (P<0.05); The levels of microRNA-21 and MMP-9 in gingival crevicular fluid of the case group were higher than those of the control group (P<0.05); miRNA-21 was positively correlated with plaque index, probing depth, clinical attachment loss, bleeding index and MMP-9 (P<0.01). Conclusion: The expression levels of microRNA-21 and MMP-9 in gingival crevicular fluid are positively correlated, which play an important role in the pathogenesis of aggressive periodontitis 2019 Vol. 25 (3): 592-594 [Abstract] ( 130 ) HTML (0 KB)  PDF (1212 KB)  ( 306 ) 595 Effect of Azithromycin combined with Tebutaline Inhalation on Inflammatory Factors and Immune Function in Children with Mycoplasmal Pneumonia XIAO Yun, WANG Jiangang, ZHANG Di DOI: 10.3969/j.issn.1006-6233.2019.03.017 Objective: To investigate the effects of azithromycin combined with teptoline inhalation on inflammatory factors and immune function in children with mycoplasmal pneumonia. Methods: A retrospective analysis of 70 children with mycoplasmal pneumonia admitted to our department from January 2015 to January 2018. All children were divided into two groups according to different treatment methods. 30 patients in the control group were given oral azithromycin tablets. treatment. Forty patients in the combined treatment group were given nebulized inhalation therapy with pedicalin on the basis of the control group. Both groups were treated for 7 days. Results: Before treatment, TNF-α was combined treatment group (70.35±3.62) pg/ml, control group (69.94±4.10) pg/ml; hs-CRP was combined treatment group (22.27±5.67) pg/ml, control Group (21.99±5.02) pg/ml, the difference was not statistically significant. After treatment, TNF-α and hs-CRP were significantly decreased in the two groups. TNF-α was (34.03±3.72) pg/ml in the combination group and (21.99±5.02) pg/ml in the control group; hs-CRP They were (8.32±2.17) pg/ml, (13.48±3.75) pg/ml, and difference is significant (P<0.05). There were no significant differences in the immunological function between the two groups before treatment (P>0.05). After treatment, IgA, IgG, C3, and C4 were significantly increased in the two groups, the difference is significant(P<0.05), and the combination treatment group was significantly better than the control group(P<0.05). The time of disappearance of fever, the time of disappearance of sputum, the time of disappearance of cough and the length of hospital stay were significantly shorter in the combined treatment group than in the control group, and the difference was not statistically(P<0.05). Conclusion: The use of azithromycin combined with teptoline inhalation in children with mycoplasmal pneumonia can better improve the inflammatory factor level and immune function of children, so that children can recover their body temperature, eliminate their voices and cure cough in a short time. Early sunrise, the effect is exact. 2019 Vol. 25 (3): 595-598 [Abstract] ( 136 ) HTML (0 KB)  PDF (1213 KB)  ( 217 ) 599 Study on the Correlation between Peripheral Blood MiR-223 and MiR-146a Levels and Acute Ischemic Stroke YANG Yuanyuan, et al DOI: 10.3969/j.issn.1006-6233.2019.03.018 Objective: To investigate the expressions of miR-223 and miR-146a in peripheral blood of acute ischemic stroke and their relationships with the occurrence of disease. Methods: 76 cases of acute ischemic stroke diagnosed and treated in the Fourth Affiliated Hospital of Harbin Medical University from January 2017 to April 2018 were selected as the subjects (case group), according to the TOAST etiological classification, there were 33 cases of main artery atherosis type, 19 cases of cardiogenic embolism type, 16 cases of small artery occlusion type, and 8 cases of unknown cause type. 60 healthy subjects were as the control group. The expression levels of miR-223 and miR-146a in peripheral blood were detected by RT-PCR, NIHSS score was used to assess the severity of acute ischemic stroke, the relationships between miR-223 and miR-146a levels with acute stroke were analyzed. Results: The expression level of miR-223 in peripheral blood of case group was significantly higher than that of control group (P<0.05), the expression level of miR-146a was significantly lower than that of the control group (P<0.05); there was no significant difference in the expression levels of miR-223 and miR-146a between the different etiological subtypes (P>0.05); there was a significant positive correlation between miR-233 level with NIHSS score in case group (r=0.774, P=0.000), there was a significant negative correlation between miR-146a level with NIHSS score (r=0.741, P=0.000); hypertension, hyperglycemia, platelet count, INR and miR-223 were risk factors for acute ischemic stroke, miR-146a is a protective factor for acute ischemic stroke. Conclusion: The miR-223 in peripheral blood of patients with acute ischemic stroke is high expressed, the miR-146a is low expressed, it is closely related to the severity of the patient's condition 2019 Vol. 25 (3): 599-602 [Abstract] ( 115 ) HTML (0 KB)  PDF (1252 KB)  ( 267 ) 603 Changes of Serum PCT, Endothelin, eNOS and NFκB levels in Patients with Intracranial Infection after Craniocerebral Trauma and their Clinical Significance YIN Jie, MOLADING·Abulizi, ZHENG Xi DOI: 10.3969/j.issn.1006-6233.2019.03.019 Objective: To investigate the changes of procalcitonin (PCT), endothelin (ET-1), endothelial nitric oxide synthase (eNOS) and nuclear factor (NFκB) levels in patients with intracranial infection after craniocerebral trauma and their clinical significance. Methods: 182 patients undergoing operation of traumatic brain injury and 30 healthy subjects were enrolled in the study. The patients were divided into infected group and uninfected group according to the criteria of intracranial infection. According to the anti-infective effect, patients in the infected group were divided into the controlled group and the uncontrolled group. Serum PCT, ET-1, eNOS and NFκB levels in each group were determined. The diagnostic efficiency of each index for infection was compared between groups. Results: Serum PCT, ET-1, eNOS and NFκB levels showed in the infected and uninfected groups were significantly higer than those in the control group (P<0.05). The levels of serum PCT, ET-1, eNOS and NFκB in the uncontrolled group were significantly higher than those in the controlled group (P<0.05). ROC curve analysis showed that the area under the curve of serum PCT was the largest and the diagnostic efficiency was the highest. With serum PCT =0.32μg/L as the best cut-off point, the diagnostic sensitivity and specificity were 88.6% and 91.6%, respectively. Conclusion: The levels of serum PCT can reflect the status of intracranial infection to a certain extent, and they can be used as reference indexes for the diagnosis of intracranial infection and evaluation of prognosis 2019 Vol. 25 (3): 603-605 [Abstract] ( 129 ) HTML (0 KB)  PDF (1357 KB)  ( 297 ) 606 Application of Video-assisted Thoracoscope Technology in Primary Lung Lobectomy and the Influence on Serum CRP and IL-6 YUAN Qingfeng, ZHANG Qi DOI: 10.3969/j.issn.1006-6233.2019.03.020 Objective: To analyze the video-assisted thoracoscope technology in primary lung lobectomy and the influence on serum c-reactive protein (CRP) and interleukin 6 (IL-6). Methods: 106 cases of primary lung cancers according to the simple random number table method those patient was divided into the 50 cases of control group and 56 cases of research group, control group traditional thoracotomy lung resection, research group video-assisted thoracoscope lung resection, then operation index, CRP, IL-6, lung function before and after surgery,postoperative complications in both groups was compared. Results: The incision length, intraoperative blood loss, postoperative pain time, hospital stay was better than control group (P<0.05); operation time, number of lymph node cleaning of two groups was no difference (P>0.05). Before operation, CRP and IL-6 in both group was no significant difference (P>0.05). After treatment, CRP, IL-6, MVV, 1s forced expiratory volume (FEV1) and forced vital capacity (FVC) in both groups were statistically significant, indicating that there were differences in treatment methods between the control group and the research group (P<0.05). CRP, IL-6 and FEV1 in the research group were lower than those in the control group at 1d and 3d after surgery, while MVV, FEV1 and FVC were higher than those in the control group. There were statistically significant differences in CRP, IL-6, MVV, FEV1 and FVC between the two groups at different time points (P<0.05). The postoperative complication rate of research group was lower than the control group (P<0.05). Conclusion: The exact effect of video-assisted thoracoscope technology in primary lung resection of lung cancer, can achieve similar to traditional thoracotomy surgical operation effect, and inhibit the overexpression of serum CRP and Il-6 and facilitate the recovery of lung function. 2019 Vol. 25 (3): 606-609 [Abstract] ( 109 ) HTML (0 KB)  PDF (1227 KB)  ( 260 ) 610 Expression and Correlation of Mismatch Repair Proteins and Epithelial-mesenchymal Transition Markers in Colorectal Cancer WU Jianlong, LIU Jianwei, LIU Haili, et al DOI: 10.3969/j.issn.1006-6233.2019.03.021 Objective: To investigate the expression and significance of mismatch repair protein (MMR) and epithelial-mesenchymal transition (EMT) markers in colorectal cancer, and to analyze the relationship between them. Methods: Immunohistochemistry was used to label the expression of mismatch repair proteins (MSH1, MSH2, MSH6, and PMS2) and epithelial-mesenchymal transition markers (E-cadherin, Vimentin) in colorectal cancer tissues. One or more of the four proteins of MSH1, MSH2, MSH6, and PMS2 were identified as mismatch repair gene defects (dMMR), and all expressions were judged to be mismatched gene integrity (pMMR). Results: 1 Among the 131 patients with colorectal cancer, 112 were pMMR, and the MMR protein expression rate was 85.50%. In 19 cases of dMMR, the MMR protein deletion rate was 14.50%. According to the analysis, in patients with colorectal cancer, dMMR is partially different from the disease site. In 32 patients with right colon cancer, there are 12 cases of dMMR, accounting for 37.5%, and among the 71 cases of left colon cancer, dMMR is common. In 4 cases, the proportion was 5.6%. In 28 cases of rectal cancer, there were 3 cases of dMMR, accounting for 10.7%. And in the lymph node metastasis group, the dMMR in the distant metastasis group and the invasive muscular layer group was significantly lower than that in the no lymph node metastasis group, the no distant metastasis group, and the invasive muscular layer group (P<0.05). The expression of E-cadherin in colorectal cancer was 2131 cases. 115 cases (86.68%) were significantly lower than adjacent tissues (99.24%), and Vimentin expression was significantly higher in 21 cases (16.03%) than in adjacent tissues (0%) (P<0.05). The expression of E-cadherin in poorly differentiated colorectal cancer, lymph node group and invasive muscle layer was much lower than that in high-medium differentiated colorectal cancer, no lymph node group, no distant metastasis and invasion of muscle layer (P<0.05). In contrast, the expression of Vimentin was reversed (P< 0.05). The expression of E-cadherin in the right colon cancer was higher than that in the left colon and rectal cancer. The expression of Vimentin right colon cancer was lower than that of left colon cancer and rectal cancer (P<0.05). Conclusion: The status of mismatch repair protein and epithelial-mesenchymal transition are related to the occurrence and progression of colorectal cancer, and affect its prognosis. It also suggests that the colorectal cancer with insignificant epithelial-mesenchymal transition has a high MMR protein deletion rate and mismatch. Repairing genetically defective colorectal cancer will have a better prognosis. 2019 Vol. 25 (3): 610-614 [Abstract] ( 82 ) HTML (0 KB)  PDF (1740 KB)  ( 302 ) 615 Correlation Analysis on the Relationship between Pain and Serum HIF-1 and VEGF Levels in Patients with Primary Liver Cancer ZHANG Geng, et al DOI: 10.3969/j.issn.1006-6233.2019.03.022 Objective: To investigate the relationship between pain and serum levels of hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) in patients with primary liver cancer. Methods: From January 2016 to November 2017, 94 patients with hepatocellular carcinoma were divided into three groups according to visual analogue scale (VAS). Thirty patients were divided into pain-free group, 39 patients in general pain group and 25 patients in severe pain group. The expression level of HIF-1 and VEGF mRNA, serum levels of HIF-1 and VEGF were measured by ELISA. Results: There was a significant difference in VAS between the three groups (P<0.05). The relative expression of HIF-1 mRNA and VEGF mRNA, serum HIF-1 and VEGF levels in severe pain group were significantly higher than those in painless group and general pain group. The relative expression of HIF-1 mRNA and VEGF mRNA, serum HIF-1 and VEGF levels in general pain group were significantly higher than those in painless group (P<0.05). VAS score was positively correlated with HIF-1 and VEGF (r>0, P<0.05). Conclusion: The expression of HIF-1 and VEGF in patients with hepatocellular carcinoma has a certain correlation with the degree of pain, which provides a new idea for clinical relief of pain in patients with hepatocellular carcinoma and has important clinical value 2019 Vol. 25 (3): 615-617 [Abstract] ( 103 ) HTML (0 KB)  PDF (1209 KB)  ( 241 ) 618 Effects of two Different Surgical Methods on Perioperative Indexes ADL Score and Postoperative Complications in Patients with Hypertensive Intracerebral Hemorrhage in Basal Ganglia ZHENG Xi, SUN Dunxin, YIN Jie DOI: 10.3969/j.issn.1006-6233.2019.03.023 Objective:To analyze the effects of two different surgical methods on perioperative indexes, activities of daily living (ADL) score and postoperative complications in patients with hypertensive intracerebral hemorrhage (HICH) in basal ganglia. Methods: 86 patients with HICH in basal ganglia who were admitted to the hospital during the period from January 2015 to January 2018 were selected as subjects. According to different surgical methods, they were divided into the observation group (40 cases) and the control group (46 cases). The observation group was treated by neuroendoscopic minimally invasive surgery, and the control group was treated by small bone window craniotomy microsurgery. The perioperative indexes and changes of intracranial pressure within 7 days after surgery were recorded. The ADL scale and the Glasgow Outcome Scale (GOS) were used to evaluate the activities of daily living and prognosis within 6 months after surgery, and complications were recorded. Results: The surgical time, intraoperative blood loss and hospital stay of the observation group were shorter/less than those of the control group, and the hematoma clearance rate was higher than that in the control group (P<0.05). The intracranial pressure of the observation group was significantly lower than that of the control group at 3 days and 7 days after surgery (P<0.05). The ADL scores of the observation group were higher than those of the control group at 3 months and 6 months after surgery (P<0.05). The GOS grade of the observation group was better than the control group at 6 months after surgery (P<0.05), and the incidence of complications in the observation group within 6 months after surgery was lower than that in the control group (5.00% vs 19.57%) (P<0.05). Conclusion: Compared with small bone window craniotomy microsurgery, neuroendoscopic minimally invasive surgery for HICH in basal ganglia can significantly improve the perioperative indexes, effectively remove hematoma, reduce intracranial pressure, improve postoperative activities of daily living and the prognosis. 2019 Vol. 25 (3): 618-622 [Abstract] ( 110 ) HTML (0 KB)  PDF (1244 KB)  ( 236 ) 623 Research of renal cell carcinoma RASSF2A gene methylation and expression status FAN Bo, WANG Zhongkai, QI Pan, et al DOI: 10.3969/j.issn.1006-6233.2019.03.024 Objective: To investigate the renal cell carcinoma RASSF2A gene methylation and expression status of research, and to analyze the occurrence of renal cell carcinoma development in rats. Methods: Methylation specific polymerase chain reaction (Methylation-Specific PCR, MSP) and reverse transcription - polymerase chain reaction (Reverse Transcriptase-PCR, RT-PCR) to detect 60 cases of renal cell carcinoma patients, paraneoplastic RASSF2A normal tissue gene expression relative situation promoter methylation status and mRNA. Results: In the 60 cases ,The methylation rate of cancer tissue was significantly higher than that of cancer paraneoplastic and normal tissues. The relative expression of RASSF2A gene mRNA was significantly lower than that of cancerous bypass and normal tissue. The difference was statistically significant (P<0.05). There was no significant difference between the methylation rate and the relative expression of mRNA (P>0.05); In the cancer tissue, the relative expression of mRNA in the methylation positive patients was lower than that of the mRNA in the negative methylation patients, and the difference was statistically significant(P<0.05). There was positive correlation between RASSF2A gene methylation and protein expression of β-catenin in renal cell carcinoma tissues(r=0.269,P<0.05). Conclusion: RASSF2A promoter hypermethylation is RCC frequent events, tumor suppressor gene RASSF2A inactivation may be one of the important reasons leading to transcriptional silencing, RASSF2A promoter hypermethylation and mRNA expression decrease may be involved in the RCC the occurrence and development.RASSF2A gene methylation might be related to the high expression of β-catenin gene. It had effect on the invasion and metastasis of renal cell carcinoma through changing the intracellular distribution of β-catenin. It indicated that this signaling pathway was involved in tumorigenesis. 2019 Vol. 25 (3): 623-626 [Abstract] ( 77 ) HTML (0 KB)  PDF (1574 KB)  ( 231 ) 627 Diagnostic Value of Conventional Ultrasound and Elastography with Fine Needle Aspiration Cytology in Thyroid Microcarcinoma WU Wenying, WANG Xiaoyan, ZHAO Li, et al DOI: 10.3969/j.issn.1006-6233.2019.03.025 Objective: To investigate the diagnostic value of conventional ultrasound(CUS),ultrasound elastography(UE) and fine needle aspiration cytology(FNA) in thyroid microcarcinoma.Methods:279 thyroid nodules confirmed by operation and pathology were retrospectively analyzed. The diagnostic criteria of thyroid cancer were greater than or equal to 4 scores of elastic score and Bethesda report system classification ≥Ⅴ, and the diagnostic sensitivity, specificity, positive predictive value, negative predictive value and correct rate were calculated respectively compared with the pathological gold standard.Result:Of the 279 nodules, 124 were malignant and 155 were benign; 121 were malignant and 158 were benign by CUS, 170 were malignant and 109 were benign by UE, 162 were malignant and 117 were benign by FNA,102 were malignant and 177 were benign by CUS+UE series,106 were malignant and 173 were benign by CUS+FNA series. The sensitivity of UE and FNA for diagnosing thyroid microcarcinoma was higher than that of CUS, while specificity and positive predictive value were lower than CUS, and the difference was statistically significant(P<0.05).The CUS+UE series specificity, correct rate, positive predictive value and Eugene index were higher than CUS, the difference was statistically significant (P<0.05). The CUS+ FNA series specificity and positive predictive value were higher than CUS, the difference was statistically significant (P<0.05).Conclusion:CUS, UE and FNA have certain deficiencies in the diagnosis of thyroid microcarcinoma. CUS+ UE series and CUS+ FNA series specificity is higher than CUS, which can improve the early diagnosis of thyroid microcarcinoma and has high clinical value. At the same time, CUS+UE series is superior to CUS+FNA series in terms of non-invasiveness and low cost, which is worthy of clinical promotion. 2019 Vol. 25 (3): 627-629 [Abstract] ( 84 ) HTML (0 KB)  PDF (1210 KB)  ( 359 ) 630 Comparative Study of Percutaneous Transforaminal Nucleotomy and Small Incision Interlaminar Nucleus Pulposus Removal for Lumbar Disc Herniation CHEN Kang, LI Keqian, YI Jianhua, et al DOI: 10.3969/j.issn.1006-6233.2019.03.026 Objective: To evaluate the efficacy and safety of percutaneous transforaminal nucleotomy and small incision interlaminar nucleus pulposus in the treatment of lumbar disc herniation. Methods: 70 patients with lumbar disc herniation from December 2016 to July 2018 were enrolled in our hospital. According to the surgical procedure, they were divided into the open window group (n=35) and the endoscopy group (n=35). The fenestration group was treated with small incision interlaminar nucleus pulposus removal, and the endoscopic group was treated with percutaneous transforaminal nucleus pulpectomy. Perioperative conditions (surgery duration, length of incision, intraoperative blood loss, bed rest time, hospital stay), preoperative and postoperative 1 d, postoperative 1 month, postoperative 2 months pain scores, preoperative and postoperative oswestry dysfunction index score (ODI) and Japanese orthopaedic association treatment score (JOA), treatment rate, and complication rate were counted. (VAS). Results: The length of incision in the endoscopy group was shorter than that in the fenestration group. The intraoperative blood loss was less than that in the fenestration group. The length of operation, bed time and hospital stay were shorter than those in the fenestration group (P<0.05). There was no significant difference VAS score between the two groups before operation. (P>0.05), the VAS scores of the two groups were lower than those before surgery (P<0.05), but there was no significant difference between the two groups (P>0.05); There was no significant difference between the two groups (P>0.05). The ODI scores of the two groups were lower than those before operation, and the JOA scores were higher than those before surgery (P<0.05). There was no significant difference (P>0.05). There was no significant difference between the excellent rate of endoscopic treatment (94.29%) and the fenestration group (88.57%) (P>0.05). The incidence of endoscopic complication (8.57%) was lower than that in the window group (28.57%) (P<0.05). Conclusion: Percutaneous transforaminal resection of nucleus pulposus and small incision fenestration of nucleus pulposus can effectively relieve pain and improve lumbar function in patients with lumbar disc herniation. However, percutaneous transforaminal resection of nucleus pulposus has more significant advantages in reducing surgical trauma, and can reduce postoperative complications and has safety. 2019 Vol. 25 (3): 630-635 [Abstract] ( 81 ) HTML (0 KB)  PDF (1240 KB)  ( 250 ) 636 Clinical Comparison of Percutaneous Transforaminal Discectomy and Discoscopic in L5/S1 Discectomy FAN Hong, MA Yong, WANG Canfeng, et al DOI: 10.3969/j.issn.1006-6233.2019.03.027 Objective: To compare the clinical efficacy of percutaneous transforaminal and discectomy with L5/S1 discectomy. Methods: 85 patients with lumbar disc herniation admitted in our hospital from September 2016 to August 2017 were randomly divided into observation group (41 cases) and control group (44 cases) according to simple random grouping. The observation group completed the discectomy with percutaneous transforaminal microsurgery, and the control group underwent discectomy under discoscopy. The clinical efficacy, intraoperative and postoperative conditions, dysfunction index (ODI), visual analog scale (VAS), and complications were compared between the two groups. Results: After treatment, the total clinical effective rate of the observation group was significantly higher than that of the control group (P<0.05). The length of incision, operation time, number of fluoroscopy, and length of hospital stay in the observation group were significantly lower than those in the control group (P<0.05). Before operation, there was no significant difference in ODI, low back pain VAS score and leg pain VAS score between the two groups (P>0.05). At 6 months after operation, the ODI, low back pain VAS score and leg pain VAS score of the observation group were significantly lower than the control group (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05). Conclusion: Percutaneous transforaminal L5/S1 discectomy has a shorter incision length, less operative time, number of fluoroscopy, and less hospital stay. The clinical effect is good, which can effectively relieve lumbar function and waist and leg pain. 2019 Vol. 25 (3): 636-638 [Abstract] ( 93 ) HTML (0 KB)  PDF (1209 KB)  ( 195 ) 639 MRI Imaging Manifestations and literature Analysis of Giant cell Reparative Granuloma of Temporal Bone GAO Yan, PAN Xiaowen DOI: 10.3969/j.issn.1006-6233.2019.03.028 Objective: To retrospectively analyze the MRI manifestations and related literature of 4 pathologically confirmed giant cell reparative granuloma of temporal bone in our hospital in recent 5 years, so as to improve the understanding of the disease and further improve the diagnostic accuracy of MRI. Methods: Four patients with giant cell reparative granuloma of the temporal bone diagnosed in our hospital in recent five years were collected. Two experienced doctors performed image analysis separately. The morphology, extent, signal, bone destruction, adjacent relationship and enhancement degree of the lesion were observed. Combined with the MRI manifestations and related literature of these four patients, some relative characteristics of the disease were summarized. Significant MRI findings. Results: The MRI findings of 4 cases were as follows: all lesions occurred in temporal bone, 1 case in left temporal bone, 3 cases in right temporal bone, unclear boundary and irregular shape. The lesions were mainly composed of mixed signal shadows with low signal intensity on T2WI. There were patchy long T1 long T2 cystic necrosis, hemoglobin deposition on short T1 and long T1 short T2. After enhancement, the lesions were unevenly enhanced (cystic change, hemorrhage and hemoglobin deposition on long T1 short T2). The heme-iron-containing area was not strengthened, and it was close to bone destruction. One case had right temporal bone mass and right middle ear mastoiditis. Two of the 4 cases were misdiagnosed as giant cell tumor of bone and chondrosarcoma before operation. Conclusion: Giant cell reparative granuloma may be considered if short T2-dominated, unevenly enhanced space occupying the temporal bone is near bone destruction, but it needs to be differentiated from giant cell tumors, chondrosarcomas, aneurysmal bone cysts and other diseases. 2019 Vol. 25 (3): 639-641 [Abstract] ( 97 ) HTML (0 KB)  PDF (3061 KB)  ( 219 ) 642 Clinical Efficacy and Safety of Pituitrin in Patients with Pulmonary Tuberculosis Hemoptysis HE Guoqing DOI: 10.3969/j.issn.1006-6233.2019.03.029 Objective: To analyze the clinical efficacy and safety of vasopressin in patients with pulmonary hemoptysis. Methods:102 cases of hemoptysis were selected and randomly divided into the control group and the observation group, 51 cases in each group; control group patients With clinical routine treatment, patients in the observation group were treated with pituitrin on the basis of conventional treatment; clinical efficacy of the two groups was compared. Results: After treatment, the difference of total effective rate, hemoptysis stop time and hemoptysis in the two groups was statistically significant (P<0.05), and there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Patients with pulmonary tuberculosis hemoptysis using pituitrin treatment can effectively improve the clinical efficacy, reduce the amount of hemoptysis, shorten the hemoptysis time, the effect is significant, safe, and worthy of clinical promotion 2019 Vol. 25 (3): 642-644 [Abstract] ( 123 ) HTML (0 KB)  PDF (1211 KB)  ( 182 ) 645 Clinical Analysis of Complications of Lumbar Spinal Stenosis in Elderly Patients with Lumbar Spinal Stenosis HE Yubao, XU Lin, REN Longxi, et al DOI: 10.3969/j.issn.1006-6233.2019.03.030 Objective: To analyze the influencing factors and incidence of complications after lumbar internal fixation in elderly patients with lumbar spinal stenosis, and to explore the relevant measures to reduce the complications. Methods: Patients aged 60 years and above with one or more comorbidities operated by multilevel instrumented lumbar fusion in our center between January 2012 and December 2013 were included in the study. Perioperative complications and their incidence were calculated. Age, number of levels fused, operative time, blood loss, and complication rates were correlated with the duration of stay and the incidence of perioperative complications using SPSS software. Measures to reduce complications are determined by these results and by review of literature. Results: Fifty two patients were included in the study (28 females and 24 males) with an average age of 69 years (range 60-84 years). Hypertension was the most common comorbidity followed by diabetes. Spondylolisthesis was the most common indication. Eleven complications were noted with an incidence of 21%. Three were systemic complications which required transfer to Intensive Care Unit. Local complications were incidental durotomy (three), transient root deficits (two), wound infections (one), and persistent radicular pain (two). Operative time and blood loss were significantly higher in patients with complications. Conclusion: The incidence of complications was strongly correlated with blood loss and operation time. The application of tranexamic acid, bone knife laminectomy, bilateral exposure and operation can reduce the operation time and bleeding volume, and help to reduce complications. 2019 Vol. 25 (3): 645-649 [Abstract] ( 82 ) HTML (0 KB)  PDF (1253 KB)  ( 243 ) 650 Clinical Efficacy of Isoniazid Combined with Glucocorticoid in the treatment of Tuberculous Pleurisy HUANGFU Tong, et al DOI: 10.3969/j.issn.1006-6233.2019.03.031 Objective: To observe the clinical efficacy of isoniazid combined with glucocorticoids in the treatment of tuberculous pleurisy. Methods:120 patients with tuberculous pleurisy admitted to the infections department of the hospital from June 2016 to March 2018 were chosen and divided into two groups by simple randomization method. The control group (n=60) was given conventional anti-tuberculosis treatment and chest drainage, the observation group (n=60) was given transthoracic injection of isoniazid combined with glucocorticoid on the basis of conventional treatment; the clinical efficacy, symptom improvement status, and lung function index[lung capacity percentage taking estimated value (VC%pred), forced lung capacity percentage taking estimated value(FVC%pred), total lung volume as a percentage of predicted value (TLC%pred)] changes before and after treatment and inflammatory factors in pleural effusion [transforming growth factor-β1 (TGF-β1), interleukin-6 (IL-) 6), tumor necrosis factor-α (TNF-α)] changes were compared between the two groups. Results: The effective rate of treatment in the observation group (91.67%)was significantly higher than in the control group (76.67) (P<0.05). The changes of pleural effusion and pleural thickness in the observation group were significantly more than those in the control group (P<0.05), and the pleural fluid absorption time was significantly shorter than that in the control group (P<0.05), the incidence of pleural thickening was significantly lower than that in the control group (P<0.05). After treatment, the increase of VC%pred, FVC%pred, TLC%pred and the decrease of TGF-β1, IL-6 and TNF-α levels in the observation group were significantly higher than those in the control group (P<0.05). Conclusion: Intrathoracic injection of isoniazid combined with glucocorticoids is effective in the treatment of tuberculous pleurisy, which can promote the loss of pleural effusion and reduce the occurrence of pleural hypertrophy 2019 Vol. 25 (3): 650-653 [Abstract] ( 88 ) HTML (0 KB)  PDF (1229 KB)  ( 234 ) 654 Analysis of the Effect of Desdrogesterone Combined with Gestrinone in the Surgical Treatment of Endometriosis YAN Lihua, LIU Chengwen, et al DOI: 10.3969/j.issn.1006-6233.2019.03.032 Objective: To analyze the effect of desdrogesterone combined with gestrinone in the surgical treatment of endometriosis. Methods: 120 conservative patients with endometriosis were randomly divided into two groups, 60 cases in each group. The control group was treated with gestrinone (Nemeyong), while the observation group was treated with didrogesterone. In the observation group, the levels of FSH, LH and E2 before and after treatment, the visual analogue pain score (VAS) before and after treatment, the changes of carbohydrate antigen 125 (CA125) levels before and after treatment, and the incidence of adverse reactions and 1-year recurrence rate were compared between the two groups. Results: After treatment, the levels of FSH, LH, E2, dysmenorrhea, sexual intercourse pain, chronic pelvic inflammation and CA125 in the two groups were lower than those before treatment (P<0.05); after treatment, the levels of FSH, LH and E2, dysmenorrhea, sexual intercourse pain, chronic pelvic inflammation and serum CA125 in the observation group were lower than those in the control group (P<0.05). There was no significant difference in incidence and recurrence rate in 1 years (P>0.05). Conclusion: Didrogesterone combined with gestrinone can improve the level of sex hormone, relieve pain, reduce the level of serum CA125 in patients with endometriosis, with fewer adverse reactions and lower recurrence rate. It is safe and reliable to use. 2019 Vol. 25 (3): 654-657 [Abstract] ( 102 ) HTML (0 KB)  PDF (1229 KB)  ( 339 ) 658 Analysis of 43 Cases of Adverse Events of Oxygen Inhalation and Preventive Measures LI Yamei, WANG Liang, LI Chunlei, et al DOI: 10.3969/j.issn.1006-6233.2019.03.033 Objectives: To explore the causes and preventive measures of adverse events of oxygen inhalation. Methods: Through the analysis of 43 cases of adverse events related to oxygen inhalation reported in our hospital from January 2017 to December 2017, the improvement measures were put forward. Results: Through this study, it was found that the reason of 43 adverse events of oxygen inhalation was due to inaccurate oxygen inhalation flow, delayed closing of oxygen, leakage of oxygen and folded oxygen inhalation tube. The reason for this event is that the operation process needs to be detailed, and the inspection effectiveness should be improved, and the misson should be done thoroughly. Conclusion: It is an important measure to improve the quality of nursing care by analyzing the causes of adverse events and then improving the workflow of oxygen inhalation. 2019 Vol. 25 (3): 658-660 [Abstract] ( 702 ) HTML (0 KB)  PDF (1189 KB)  ( 4238 ) 661 Effect of Video-assisted Thoracoscopic Resection of Mediastinal Tumors on Surgical Parameters, Postoperative Recovery and Prognosis in Patients with Mediastinal Tumors LIANG Lihui, LI Changbo, YU Defu DOI: 10.3969/j.issn.1006-6233.2019.03.034 Objective: To investigate the effect of video-assisted thoracoscopic resection of mediastinal tumor on surgical parameters, postoperative recovery and prognosis in patients with mediastinal tumor. Methods: 60 patients with mediastinal tumors admitted to our hospital from June 2013 to June 2018 were randomly divided into control group and experimental group according to random number table method. The experimental group was treated with mediastinal tumors resection under video-assisted thoracoscopy, while the control group was treated with standard thoracotomy. Relevant indexes of operation and recovery were observed, and the incidence of postoperative complications was compared between the two groups. Results: There was no significant difference in the total operation time between the two groups (P>0. 05), the time of thoracotomy, the amount of bleeding and the time of closure were (12.07±3.27) min, ( 13.26±4.33) ml, (11.09±2.14) min;, respectively, which were significantly lower than those in the control group (18.20±2.34) min, (24.98±8.43) ml, (21.09±3.28) min (t=5.323,t=5.293,t=4.985,P< 0. 05). Postoperative time of tubing in the trial group The postoperative hospitalization time was (3.09±0.89) d, (354.45±101.22) ml, (7.15±2.35) days, which was significantly lower than that in the control group (5.59 ±1.23) d, (643.34±144.20) ml, (10.98±3.17) d (t=5.045, P<0.05). In the control group, 8 patients had postoperative complications, while in the trial group, only 3 patients had postoperative complications. The incidence of postoperative complications in the trial group was as follows: 10.00% was significantly lower than that in the control group 26.67% (χ2= 8.374, P<0.05). Conclusion: Video-assisted thoracoscopic resection of mediastinal tumors can effectively reduce the trauma, shorten the time of postoperative recovery, and have a high clinical effect and few postoperative complications, so it is worth popularizing and applying in clinic. 2019 Vol. 25 (3): 661-663 [Abstract] ( 110 ) HTML (0 KB)  PDF (1213 KB)  ( 193 ) 664 Effect of Different Operative Approaches on Lymph Node Dissection and treatment of Patients with Esophageal Carcinoma MA Shengmao, et al DOI: 10.3969/j.issn.1006-6233.2019.03.035 Objective: To analyze the effect of different operative approaches on lymph node dissection and treatment of esophageal cancer patients. Methods: 90 patients with esophageal cancer admitted to our hospital from May 2016 to May 2018 were retrospectively studied. According to the different surgical approaches, the two groups were divided into two groups: group A was treated with lvor-Lewis operation, while group B was treated with left chest operation. The number of abdominal and thoracic lymph node dissection and the incidence of complications were compared between the two groups. Results: The metastatic rate of upper mediastinal lymph nodes in group A was 24.00%, which was significantly higher than that in group B 10.00%(χ2=6.945,P<0.05), and that in group A was 20.00%, which was significantly higher than that in group B (χ2=7.495,P<0.05). There was no significant difference in lymph node metastasis between the lower mediastinum and abdominal region between the two groups (P>0.05). The incidence of arrhythmia, anastomotic stenosis, delayed gastric emptying, anastomotic fistula and chest infection were not significantly different between the two groups (all P>0.05). ). Conclusion: Compared with the left thoracic approach, lvor-Lewis two-field dissection is more thorough and effective in the treatment of metastatic lymph nodes in patients with esophageal cancer, which is worthy of wide clinical application. 2019 Vol. 25 (3): 664-666 [Abstract] ( 103 ) HTML (0 KB)  PDF (1217 KB)  ( 159 ) 667 Effect of Intravenous and Local combination of Tranexamic Acid on Fibrinolytic Activity and Blood Loss in Patients Undergoing Total Knee Arthroplasty SUN Bo, et al DOI: 10.3969/j.issn.1006-6233.2019.03.036 Objective: To investigate the effect of intravenous and local combination of tranexamic acid on fibrinolytic activity and blood loss in patients undergoing total knee arthroplasty. Methods: 100 cases of knee replacement patients treated in our hospital from March 2015 to March 2018 were randomly divided into observation group (n=52) and control group (n=48). The control group was treated with local medication, while the observation group was treated with intravenous and local combined medication. Hemoglobin, hematocrit, fibrinogen (FIB), D-dimer (D-D), maximum loss of hemoglobin, total drainage, occult blood loss, total blood loss, blood transfusion patients and subcutaneous ecchymosis area were compared between the two groups before and after operation. Results: There was no significant difference in hemoglobin and blood cell contents before operation between the two groups. After surgery, the hemoglobin and blood cell contents of the two groups were significantly decreased, and the hemoglobin and blood cell contents of the observation group were significantly higher than those of the control group (P<0.05). There was no significant difference in the level of fibrinolysis before operation between the two groups. After surgery, FIB and d-d were significantly increased in both groups, and FIB and d-d were significantly lower in the observation group than in the control group (P<0.05). After surgery, the maximum hemoglobin loss, total outflow, recessive blood loss, total blood loss, blood transfusion patients and subcutaneous blood stasis area of the observation group were significantly lower than those of the control group (P<0.05). Conclusion: The use of tamaric acid vein combined with local medication in total knee replacement patients has significant effect, which can effectively reduce the blood loss and blood transfusion rate of patients, and is worthy of promotion and application. 2019 Vol. 25 (3): 667-670 [Abstract] ( 98 ) HTML (0 KB)  PDF (1234 KB)  ( 218 ) 671 Detection of Pathogenic Microorganism of Infantile Siarrhea and Analysis of Changes of IFN-γ IL-6 and TGF-β PAN Shu, ZHANG Jing, MA Yushan DOI: 10.3969/j.issn.1006-6233.2019.03.037 Objective: To analyze the pathogenic microorganism of infantile diarrhea pathogenic factors and the changes of serum interferon-γ(IFN-γ), interleukin-6 (IL-6), and transgenic growth factor -β(TGF-β). Methods: 100 cases of Infantile diarrhea children who treated from May 2015 to May 2018 in our hospital, according to the severity of the disease those children were divided into 41 cases of light group and 59 cases of heavy group, and 41 cases of healthy infants were selected for outpatient physical examination in the same period as a control group. The distribution of pathogenic microorganisms in infants and young children with diarrhea was analyzed, and the serum levels of IFN-γ, IL-6 and TGF-βin each group were compared, and the correlation was analyzed. Results: A total of 100 stool samples from infants with diarrhea were collected,a total of 80 pathogenic microorganisms were detected,the total detection rate was 83.00%, which the detection rate of rotavirus was 37.34%, the detection rate of calicivirus was 28.91%, the detection rate of small double-section virus was 9.63%, the detection rate of adenovirus was 8.43%, The detection rate of bacteria was 6.02%, and the detection rate of remaining viruses and bacteria was low. The serum levels of IFN-γ, IL-6 and TGF-β in the research group were lower than those in the control group, and the difference was statistically significant (P<0.05). The levels of serum IFN-γ, IL-6 and TGF-β in the severe group were higher than those in the light group (P<0.05).The areas of serum IFN-γ, IL-6, TGF-β and combined index ROC curves were 0.770, 0.788, 0.859, 0.940,the ROC curve area of the combined indicator was significantly higher than the individual indicators of IFN-γ, IL-6 and TGF-β. Conclusion: rotavirus is the main pathogenic microorganism of infantile diarrhea,analysis of serum IFN-γ, IL-6, TGF-β levels can be useful for the observation of disease diagnosis and progression. 2019 Vol. 25 (3): 671-674 [Abstract] ( 92 ) HTML (0 KB)  PDF (1343 KB)  ( 199 ) 675 Analysis of Related Factors Affecting Parenteral Nutrition Associated Cholestasis in Premature Infants WANG Caifei DOI: 10.3969/j.issn.1006-6233.2019.03.038 Objective: To analyze the related factors of parenteral nutrition associated cholestasis in preterm infants. Methods: 150 premature infants treated with parenteral nutrition (PN) in our hospital from June 2016 to May 2018 were divided into two groups according to whether they belong to parenteral nutrition-related cholestasis (PNAC), non-PNAC group and PNAC group, including 100 non-PNAC premature infants and 50 PNAC premature infants. The clinical data of two groups of premature infants were compared. Logistic regression analysis was used to analyze the risk factors of PNAC in premature infants. Results: The gestational age and birth weight of children in non-PNAC group were (34.93±1.92) weeks and (1398.34±283.44) g, respectively, higher than those in PNAC group (30.02±1.23) weeks) and (1243.45±213.33) g (t=4.384, t=9.233, all P<0.05). The rates of anemia and neonatal infection in the PNAC group were 82.00% and 76.00%, respectively, which were significantly higher than those in the non-PNAC group 57.00% and 53.00% (χ2=7.384, χ2=7.555, P<0.05). The fat milk calorie ratio, amino acid caloric ratio, fasting time and feeding difficulty rate in non-PNAC group were significantly lower than those in PNAC group (t = 4.934, t = 5.874, χ2=7.384, P< 0. 05). The total calorie and milk caloric ratio in PNAC group were significantly lower than those in non-PNAC group (t = 6.372,t = 5.483, P< 0. 05). Neonatal infection, gestational age, fat milk caloric ratio, amino acid supply calorie ratio, fasting time and so on are all related to the occurrence of PNAC in preterm infants. The risk factors of PNAC (all P< 0. 05) and the ratio of calorie supply of milk were the protective factors of PNAC in preterm infants (P<0. 05). Conclusion: The related factors affecting the occurrence of parenteral nutrition-related cholestasis in preterm infants mainly include neonatal infection, low gestational age, high calorie supply ratio of amino acids and fat emulsion, and long fasting time. To formulate corresponding preventive measures can effectively reduce the incidence of PNAC in preterm infants. 2019 Vol. 25 (3): 675-678 [Abstract] ( 83 ) HTML (0 KB)  PDF (1215 KB)  ( 203 ) 679 Observation of Effect of Himpelson and Low Dose Oxytocin on Induced Labor with Oligohydramnios in Full-term Pregnancy YAO Jing DOI: 10.3969/j.issn.1006-6233.2019.03.039 Objective: To explore the therapeutic effect of Himpelson and low dose oxytocin on induced labor with oligohydramnios in full-term pregnancy. Methods: The clinical data of 48 cases of full-term pregnant women with oligohydramnios treated with Dinoprostone for labor induction (observation group) and low-dose oxytocin for labor induction (control group) were retrospectively analyzed. The cervical ripening (Bishop score) was compared between the two groups before administration and after 12h of administration, and the time required for labor, labor induction, pregnancy outcomes and occurrence of complications were recorded in the two groups. Results: After 12h of administration, the Bishop score in the two groups was higher than that before administration (P<0.05), and the score in observation group was higher than that in control group (P<0.05). The time required for labor, and the total incidence rates of maternal adverse outcomes, fetal adverse outcomes and complications in observation group were significantly lower than those in control group (P<0.05), and the success rate of induction and the total effective rate of labor induction were significantly higher than those in control group (P<0.05). Conclusions: Dinoprostone and low-dose oxytocin are beneficial for labor induction in pregnant women with oligohydramnios in full-term pregnancy. However, Dinoprostone can promote cervical ripening and provide a more suitable intrauterine environment for labor induction, and increase the success rate of labor induction, and reduce the incidence rate of complications, and it has a positive effect on improving the maternal-infant outcomes. 2019 Vol. 25 (3): 679-682 [Abstract] ( 83 ) HTML (0 KB)  PDF (1202 KB)  ( 299 ) 683 Effective Dose of Small Volume Fractional Dexmedetomidine for Preoperative Sedation in Children ZHOU Shaowu, YANG Kun, LIU Hongqiang, et al DOI: 10.3969/j.issn.1006-6233.2019.03.040 Objective: To determine the effective dose of dexmedetomidine (ED50) and 95% effective dose of dexmedetomidine (ED95) for sedation before operation in children. Methods: The American Society of Anesthesiologists (ASA) Grade I, aged from September to 5 years, was selected to perform laparoscopic high ligation of indirect inguinal hernia sac under general anesthesia in 30 children. One hour before operation, small volume fractional administration of dexmedetomidine: dexmedetomidine was not diluted, 0.1 ml or 10 UG was taken with a small spoon every time, every 3 minutes, less than 0.1 ml was taken at one time until the end of the treatment. According to the sedative effect of the previous case, the next case increased or decreased by 0.25 ug/kg. The ED50, ED95 and 95% CI of dexmedetomidine were calculated by probabilistic unit regression analysis. Results: The ED50 of small volume fractional administration of dexmedetomidine was 2.295 ug/kg, (95% CI: 2.170-2.422 ug/kg) and ED95 was 2.564, (95% CI: 2.472-3.294 ug/kg). Conclusion: Small volume fractional administration of dexmedetomidine for pediatric preoperative sedation has better compliance and higher oral mucosal absorption rate. The ED50 determined by modified sequential method is 2.295 ug/kg and ED95 is 2.564 ug/kg. 2019 Vol. 25 (3): 683-684 [Abstract] ( 92 ) HTML (0 KB)  PDF (1355 KB)  ( 266 ) 685 Evaluation of Postoperative Comprehensive Intervention on Acute Circulation Occlusion after Mechanical Thrombectomy LIU Yan, QI Baozhu, YAN Lina, et al DOI: 10.3969/j.issn.1006-6233.2019.03.041 Objective: To observe the effect of postoperative comprehensive intervention on acute occlusion of large circulation vessels after mechanical embolization of intracranial arteries. Methods:From January 2015 to September 2018, 83 patients with acute occlusion of posterior circulation great vessels underwent mechanical embolization of intracranial artery in our hospital were randomly divided into two groups. Patients in observation group (n=42) received routine nursing plus comprehensive intervention, while those in control group (n=41) received routine nursing only. The incidence of complications, the average length of stay and the satisfaction rate of nursing care between the two groups were compared. Results:The incidence rate and average hospitalization time of the observation group were significantly better than those of the control group, which were 10.24% vs 25.26%, 10.6 + 2.5 vs 14.3 + 3.2, P < 0.05, respectively. Conclusion:For patients with acute posterior circulation occlusion undergoing mechanical thrombectomy with Solitaire AB stent, postoperative comprehensive intervention can effectively reduce the incidence of complications and shorten the average hospital stay. 2019 Vol. 25 (3): 685-687 [Abstract] ( 109 ) HTML (0 KB)  PDF (1198 KB)  ( 269 ) 688 Observation Curative Effect of Acupuncture Combined with Biofeedback on Postpartum Constipation LIU Jingzhou, GAO Yingjie, LIU Baolin, et al DOI: 10.3969/j.issn.1006-6233.2019.03.042 Objective: To study the effect of acupuncture combined with biofeedback on postpartum constipation. Methods: 60 patients with postpartum constipation were treated with acupuncture combined with biofeedback therapy. The self-rating symptoms (PAC-SYM) and constipation quality of life (PAC-QOL) were used as evaluation systems to observe clinical efficacy and quality of life. Results: The fecal traits, rectal symptoms and abdominal symptoms scores after trentment of the 60 patients were(1.46±0.12), (1.45±0.09)and(1.38±0.07)points, which were significantly better than the scores of the pre-treatment(2.73±0.23),(2.71±0.21)and (2.72±0.18)points (P<0.05); the physiological status, mental state, anxiety and social satisfaction score after treatment were(1.42±0.08)、(1.57± 0.11)、 (1.45±0.08)and(1.36±0.12)points, which were significantly better than the scores of the pre-treatment(2.93±0.18),(2.98±0.23),(2.76±0.17)and(1.36±0.12)points,(P<0.05). Conclusion: Acupuncture combined with biofeedback for the treatment of postpartum constipation has a definite curative effect and low cost, which can alleviate the patient's pain and improve the quality of life of patients. 2019 Vol. 25 (3): 688-690 [Abstract] ( 82 ) HTML (0 KB)  PDF (1191 KB)  ( 208 ) 691 Clinical Efficacy of Aspirin combined with Low Molecular Weight Heparin in the treatment of Fetal Growth Restriction and its Influence on Fetal Blood Flow Parameters and Maternal and Infant Outcomes CHEN Yongli DOI: 10.3969/j.issn.1006-6233.2019.03.043 Objective: To investigate the clinical curative effect of aspirin combined with low molecular weight heparin (LMWH) in the treatment of fetal growth restriction (FGR) and the influence on fetal blood flow parameters and maternal and neonatal outcomes. Methods: 180 pregnant women with FGR caused by umbilical cord and placental abnormalities were divided into the study group (100 cases) and the control group (80 cases) according to different regimens. The situation of fetal development was determined after admission and confirmed diagnosis and was monitored. The control group was treated by subcutaneous injection of LMWH preparation Low Molecular Weight Heparin Calcium Injection. On the basis, the study group was treated with oral Aspirin Enteric-coated Tablets. According to the results of color Doppler ultrasonography, the curative effect was evaluated. The parameters of umbilical artery, such as fetal pulsatility index (PI), resistance index (RI), peak systolic blood flow velocity (S) and peak diastolic end blood flow velocity (D) were detected. Maternal and neonatal outcomes were statistically analyzed. Results: The total effective rate of treatment in the study group was significantly higher than that in the control group (79.00% vs 65.00%) (P<0.05). PI, RI and S/D of the two groups were close before treatment (P>0.05), but they were significantly decreased after treatment, and the decrease in study group was significantly greater than that in the control group (P<0.05). The incidence rates of placental abruption, fetal distress, neonatal asphyxia, premature infants and extremely low birth weight infants in the study group were slightly lower than those in the control group (P>0.05). Conclusion: Aspirin combined with LMWH can effectively improve the fetal blood flow parameters and improve the clinical curative effect on FGR to a certain extent. However, the improvement of curative effect and maternal and neonatal outcomes is limited. 2019 Vol. 25 (3): 691-694 [Abstract] ( 110 ) HTML (0 KB)  PDF (1231 KB)  ( 271 ) 698 Study on Effect of Nerve Mobilization on Shoulder Pain in Hemiplegic Patients after Stroke CHEN Huanzhou DOI: 10.3969/j.issn.1006-6233.2019.03.045 Objective: To observe the effect of nerve mobilization of upper limb on shoulder pain in hemiplegic patients after stroke. Methods: 60 patients with hemiplegic shoulder pain after stroke were randomly divided into research group (n=30) and control group (n=30) using random number table. Compare the pain degree, shoulder joint activity, upper limb motor function and daily living ability of the two groups before and 3 months after treatment. Results: The score of NAS decreased in both groups after treatment (P<0.05), and was lower in the research group than in the control group (P<0.05). The score of shoulder joint activity, FMA and MBI increased in both groups after treatment (P<0.05), and was higher in the research group than in the control group (P<0.05). Conclusion: Nerve mobilization of upper limb could further relieve the shoulder pain and muscle spasm, then improve the motor function of upper limb and ADL in patients with hemiplegia after stroke. 2019 Vol. 25 (3): 698-701 [Abstract] ( 106 ) HTML (0 KB)  PDF (1197 KB)  ( 214 )

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