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2017 Vol. 23, No. 3
Published: 2017-03-20
353
Expression and Significance of Matrix Metalloproteinase and Matrix Metalloproteinase Inhibitors in Spinal Tuberculosis Intervertebral Disc
GAO Xiaoliang, YANG Xiaohui, HUANG Weimin, et al
DOI: 10.3969/j.issn.1006-6233.2017.03.001
Objective:
To investigate the expression and significance of matrix metalloproteinase MMP-9, MMP-13 and their inhibitors TIMP-1, TIMP-3 in spinal tuberculosis intervertebral disc tissue.
Methods:
48 cases of patients with spinal tuberculosis treated by operation from January 2012 to January 2016 in our hospital were selected as TB group, another 48 cases with disc herniation treated by operation were selected as ID group, and patients with traumatic spinal fractures treated in our hospital in the same period were selected as the control group. Then the positive rate and the level of expression in the three groups were detected by immunohistochemistry assay and real-time quantitative PCR (RT-PCR) technique.
Results:
The positive rate of MMP-9 was 93.75%, MMP-13 positive rate was 89.58%, TIMP-1 positive rate was 87.50%, TIMP-3 positive rate was 91.67% in TB group, which were all significantly higher than those in ID group (70.83%, 66.67%, 68.75%, 64.58%) and the control group (20.83%, 16.67%, 18.75%, 10.42%) (X2=56.541,54.665,49.886 and 66.544,respectively, P<0.05); The expression levels of MMP-9, MMP-13, TIMP-1, TIMP-3TB in intervertebral disc tissue group were significantly higher than those in ID group and the control group (F=12.451,37.423,17.483 and 9.167,respectively, P<0.05), the ratio of MMP-9 / TIMP-1 and MMP-13 / TIMP-3 all increased.
Conclusion:
MMP-9, MMP-13, TIMP-1, TIMP-3 are highly expressed in spinal tuberculosis disc tissue, which result in the imbalance of MMP-9 / TIMP-1, MMP-13 / TIMP-3, indicating that the matrix metal proteases (MMPs) and matrix metalloproteinase inhibitors (TIMPs) may participate in the damages of spinal tuberculosis intervertebral disc.
2017 Vol. 23 (3): 353-355 [
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356
Antiviral Effect in Patients with Chronic Hepatitis C Treatedwith Peg-interferon α-2a Combined with Ribavirin
YAO Weimin, GUO Jianwen, CHEN Yan
DOI: 10.3969/j.issn.1006-6233.2017.03.002
Objective:
To observe the pathological changes of chronic hepatitis C after the treatment of peg-interferon α-2a combined with ribavirin.
Methods:
40 patients with chronic hepatitis C visited our hospital from October 2014 to October 2015 as the research object, were randomly divided into two groups, 20 cases in each group. Observation group was treated with peg interferon α-2a and ribavirin, the control group was given general hepatoprotective treatment, The levels of ALT, HCVRNA and the pathological tissue of the two groups were compared.
Results:
After treatment, the observation group ALT recovery rate was 80%, there's no significant difference with the control group (P>0.05); the observation group HCVRNA negative rate was 90%, compared with the control group were significantly higher (P<0.05); liver inflammation and fibrosis of the observation group was significantly lower than before, and significantly lower than the control group (P<0.05).
Conclusion:
Antiviral treatment can significantly reduce the degree of liver inflammatory activity and fibrosis.It is of great significance to evaluate the effect of antiviral therapy from the pathological point.
2017 Vol. 23 (3): 356-358 [
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359
Risk Factor After Treatment for Intracranial Hematoma Puncture Drainage in Patients with Intracranial Infection
FANG Dan
DOI: 10.3969/j.issn.1006-6233.2017.03.003
Objective:
To study the patients with intracranial infection after intracranial hematoma puncture drainage treatment of risk factors and analyzed.
Methods:
From May 2014 to July 2016 in our hospital happened after cerebral hemorrhage of puncture drainage treatment of 56 patients with intracranial infection for observe group.Another line close puncture drainage treatment did not occur in patients with intracranial infection after 58 cases as control group.Respectively compared two groups of age,diabetes mellitus,merging,hypoalbuminemia,the location of drainage tube drainage tube placement time,number of injections of urokinase,cerebrospinal fluid leakage and prevent use of antimicrobial agents.Multiariable Logistic regression analysis was carried on.
Results:
The average age group,the number of diabetes accounted for,the combining hypoalbuminemia number proportion respectively(65.3±11.4),73.21%(41/56),75.00%(42/56),were significantly higher than that of control group(47.2±9.3),43.10%(25/58),39.66%(23/58),differences were statistically significant(all P<0.05).Observation group of number placed on the drainage tube ventricle(ratio and mixing time number 5 d or higher than the control group,differences were statistically significant(all P<0.05).Observation group of injection of urokinase or greater than three times the number of and cerebrospinal fluid leakage rate were significantly higher than that of control group,differences were statistically significant(all P<0.05).After multiariable Logistic regression analysis,age,diabetes mellitus,merging,hypoalbuminemia,drainage tube location,time,number of injections of urokinase,cerebrospinal fluid leakage were intracranial hematoma puncture drainage after treatment of patients with intracranial infection risk factors.
Conclusion:
After treatment for intracranial hematoma puncture drainage in patients with intracranial infection risk factors including age,diabetes mellitus,merging,hypoalbuminemia,drainage tube location,time,number of injections of urokinase,cerebrospinal fluid leakage,etc.
2017 Vol. 23 (3): 359-362 [
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363
The Effects of VPA Combined with PTX on the Expression of Angiogenesis Related Factors in A549 Lung Cancer Cell Line
ZHU Cuimin GAO Feifei, LIANG Yunwei, et al
DOI: 10.3969/j.issn.1006-6233.2017.03.004
Objective:
To investigate the effects of valproic acid ,one of histone deacetylase(HDAC) inhibitors, combinations with PTX, on the expression of vascular endothelial growth factor (VEGF) and Ang-2 of the lung cancer cell line A549 cell. Explore their significance of cell proliferation, apoptosis and metastasis on A549 cell.
Methods:
Set the A549 cell to four groups:control group,PTX group,VPA group and VPA combined with PTX group. Determine the mRNA and protein of VEGF and Ang-2 by quantitative PCR and Western Blot.
Results:
The PTX group,VPA group and VPA combined with PTX can downregulate the VEGF and Ang-2 in mRNA and protein level. The combination group of lowest level of these two genes and protein. The difference between the groups was statistically significant.
Conclusion:
HDAC inhibitor valproic acid may depend on its regulation of histone to inhibite cell proliferation , promote cell apoptosis of A549 cell and inhibit the angiogenesis by regulating the VEGF and Ang-2 expression.
2017 Vol. 23 (3): 363-365 [
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366
Analysis on Relationship between Urinary Albumin Excretion with Diabetic Retinopathy in Type 2 Diabetics
SUN Guanyuan, WANG Ying
DOI: 10.3969/j.issn.1006-6233.2017.03.005
Objective:
To analyze the relationship between urinary albumin excretion with diabetic retinopathy in type 2 diabetics.
Methods:
320 patients with type 2 diabetics were divided into normal albuminuria group(NA, n=68, 24h-urinary albumin≤30mg), microalbuminuria group(MAU, n=135, 30mg＜24h-urinary albumin＜300mg) and macroalbuminuria group(CAU,n=117,24h-urinary albumin≥300mg) . All the patients were measured the 24h-urinary albumin and examined by digital retinal photographs, thus we can analyze the relationship between urinary albumin excretion with diabetic retinopathy in type 2 diabetics.
Results:
Simple retinopathy detection were 10.1%,42.9% and 43.3% in normal albuminuria group, microalbuminuria group and macroalbuminuria group, fertile retinopathy detection rate were 5.2%,15.8% and 35.4% in the 3 groups , statistically significant differences existed in the rate of simple retinopathy detection and fertile retinopathy detection of different groups(P＜0.05). Correlation analysis results showed that there is positive correlation between urinary protein excretion and diabetic retinopathy in patients with type 2 diabetes(r=0.526, P＜0.05).
Conclusion:
Urinary protein excretion were significantly correlated with the incidence of diabetic retinopathy in patients with type 2 diabetes, maybe they have common pathophysiological basis.
2017 Vol. 23 (3): 366-368 [
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369
The Effects of WBC CRP and WBC on Diagnosing Brain Surgery Patients with Fever
LI Bin, CHEN Jian, TAN Yong, et al
DOI: 10.3969/j.issn.1006-6233.2017.03.006
Objective:
To discuss the effects of WBC, CRP and WBC on diagnosing brain surgery patients with fever.
Methods:
98 brain surgery patients with fever who accepted treatment in our hospital from Aug.2014 to Aug. 2015 were included in this study and divided into two groups according to the infection degree. 46 patients were in the infection group and 52 cases in non-infection group. On the other hand, 50 patients accepted brain surgery patients without fever were selected as control group.
Results:
The CRP, WBC level of infection group and non-infection grouop were significantly higer than those of the control group(P＜0.05). There was no significant different between the control group and non-infectin group of the PCT level(P＞0.05) whereas the PCT level of infection group was significant higher than the other two group(P＜0.05). The sensitivity and specificity of PCT were significantly higher than CPR and WBR (P＜0.05), and the area under ROC curve was close to 1.
Conclusion:
PCT has the better diagnosing effect comparing to CRP and WBC, especially when patients with fever, which could be the main index of the clinical diagnosis.
2017 Vol. 23 (3): 369-370 [
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371
The Relationship between Preoperative BNP and Copeptin Concentration and Cardiovascular Events in Elderly Patients with Non Cardiac Surgery
XING Xubin, et al
DOI: 10.3969/j.issn.1006-6233.2017.03.007
Objective:
To investigate the relationship between the changes of type B natriuretic peptide (BNP) and peptide (copeptin) concentration and cardiovascular events in elderly patients with non cardiac surgery.
Methods:
From August 2012 to January 2013, patients with the occurrence of cardiovascular events were divided into two groups, and analyzed the changes of BNP and copeptin concentration patients of the two groups before and after surgery.
Results:
BNP concentration more than 100 ng/mL for cardiac events had a role in the occurrence of cardiac events in patients with plasma BNP,which concentrations were significantly higher than those who did not occur in patients with cardiac events. The higher the concentration of copeptin in plasma, the greater the possibility of the occurrence of cardiac events in patients, the results were statistically significant.
Conclusion:
Preoperative BNP and copeptin concentrations are higher than the normal value of the elderly patients with non cardiac surgery, cardiovascular events, the patients should be considered the corresponding risk factors.
2017 Vol. 23 (3): 371-373 [
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374
Effects of Clopidogrel Combined with Aspirin on Platelet Activation and Aggregation in Patients with Acute Cerebral Infarction
QI Huimin
DOI: 10.3969/j.issn.1006-6233.2017.03.008
Objective:
To explore the clinical effects of clopidogrel combined with aspirin on platelet activation and aggregation in patients with acute cerebral infarction.
Methods:
A total of 92 patients with acute cerebral infarction admitted in our hospital from October 2015 to September 2016 were randomly divided into control group and observation group according to the different treatment. The patients in the control group were treated with aspirin, The observation group were treated with clopidogrel on the basis of control group.The platelet activating factor, platelet count and platelet volume were measured after 2 weeks of treatment, detected the level of ADP and AA pathway-induced platelet inhibition rate, the clinical efficacy of the two groups.
Results:
After treatment, CD62p and CD63 were significantly decreased (P <0.05).The level of CD62p and CD63 of platelet activation markers in the observation group were significantly lower than those in the control group after treatment (P<0.05). There was no significant difference in PLT and MPV between the two groups (P> 0.05). The platelet inhibition rate of AA and ADP in the observation group were significantly higher than those in the control group (P <0.05). The total effective rate of clinical treatment in observation group was significantly higher than that in control group (P <0.05).
Conclusion:
Clopidogrel combined with aspirin can effectively inhibit platelet activation and aggregation in patients with acute cerebral infarction and improve the clinical curative effect.
2017 Vol. 23 (3): 374-376 [
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377
Effect of Pidotimod on Immune and Inflammatory Factors of Children with Mycoplasma Pneumonia
CHEN Yanling, et al
DOI: 10.3969/j.issn.1006-6233.2017.03.009
Objective:
To observe the effect of pidotimod on immune and inflammatory factors of children with mycoplasma pneumonia.
Methods:
80 cases of children with mycoplasma pneumonia treated in our hospital from March 2013 to July 2015 were selected and divided into control group and observation group according to random stratified grouping method, 40 cases in each group. The control group was given Azithromycin for treatment, while the observation group was given pidotimod on the basis of the treatment in the control group, then the level changes of immune function and inflammatory factors in the two groups were compared.
Results:
After treatment, immune function detecting indexes (IL-10,IL-6,TNF-α)in the observation group were all lower than those in the control group (t=5.731,P<0.05, inflammatory factor(CD3+,CD4+,CD8+,CD4+/CD8+)level in the observation group were all higher than those in the control group(t=5.538,P<0.05), CD8+ level in the observation group was lower than that in the control group(t=5.652,P<0.05).
Conclusion:
Clinical application of pidotimod for the treatment on children with mycoplasma pneumonia can improve the body's inflammatory status and immune function.
2017 Vol. 23 (3): 377-379 [
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380
The Effect of Four Surgical Approaches on the Semen Quality and Pregnancy Rate in Patients with Subclinical Varicocele
SU Hongwei, et al
DOI: 10.3969/j.issn.1006-6233.2017.03.010
Objective:
To investigate the effects of four different surgical methods for the treatment of subclinical varicocele.
Methods:
235 patients in our hospital were randomly divided into 4 groups: Group A with 60 cases was treated with traditional trans inguinal canal operation, group B with 58 cases was treated with subinguinal microscopic varicocelectomy, group C with 62 cases was treated with inguinal microscopic spermatic vein ligation, group D with 55 cases was treated with laparoscopic spermatic vein ligation. The operation time and hospital stay of 235 varicocele patients were recorded, and the postoperative recovery, complications, recurrence rate, the quality of semen before and after operation, and the pregnancy rate were compared.
Results:
The operation time of group A was the shortest of the four methods, but the hospital stay was longer than other groups (P < 0.05). The symptoms of patients in each group were significantly improved after six months, while the improvement rate of group B was higher than that of group A and group D (P < 0.05), but no statistical difference was found when compared with group C. The complication rate and recurrence rate in group B were lower than those in the other groups. The sperm quality in each group were significantly improved after 3, 6 and 12 months, in which the sperm motility of group B was obviously better than others. The pregnancy rate of the spouses in each group were 23.33%, 41.38 %, 25.81%, 27.27% respectively. There was statistically difference in the conception rate in 12 months after the surgery between group B and the other three groups.
Conclusion:
The four kinds of surgical procedures can significantly improve the semen quality and conception rate. But the subinguinal microscopic varicocelectomy has obvious advantages in reducing the recurrence rate and improve the sperm quality and pregnancy rate of spouse, and it is worth recommending for clinical applications.
2017 Vol. 23 (3): 380-383 [
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384
The Effect of Ultrasound Guided Percutaneous Catheter Drainage in the Treatment of Severe Acute Pancreatitis
HUI Min, LIU Xing, LAN Yu, et al
DOI: 10.3969/j.issn.1006-6233.2017.03.011
Objective:
To study the clinical curative effect of ultrasound guided percutaneous catheter drainage in the treatment of severe acute pancreatitis.
Methods:
84 cases with severe acute pancreatitis cured in our hospital from March 2014 to November 2015 were selected as the research object. All of them were divided into control group and observation group according to the random number table, 42 cases in the each group. Patients in the control group implemented with conservative treatment, and the observation group treated with ultrasound guided percutaneous catheter drainage on the basis of the above treatment measures. The clinical efficacy and complications of the two groups were analyzed.
Results:
After treatment, blood WBC, serum amylase in the observation group were significantly lower than those in the control group (P < 0.05). The serum calcium level in the observation group was higher than the control group, the difference was statistically significant (P < 0.05). The symptoms disappeared time, blood amylase recovery time and hospitalization time in observation group were significantly shorter than the control group (P < 0.05). The incidence abdominal infection and organ failure in observation group was significantly higher than the control group, the difference was statistically significant (P < 0.05).
Conclusion:
Ultrasound guided percutaneous catheter drainage has many advantages, has definite curative effect on severe acute pancreatitis, which has high value of clinical application.
2017 Vol. 23 (3): 384-386 [
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387
Comparing the Impact of Laparoscopic Surgery with Open Surgery for Severe Acute Peripheral Blood T Lymphocyte Subsets
ZHU Yufei, WU Tao, XU Jian, et al
DOI: 10.3969/j.issn.1006-6233.2017.03.012
Objective:
To analyze the impact of laparoscopic surgery and open surgery for severe acute peripheral blood T lymphocyte subsets.
Methods:
98 cases of patients with severe acute pancreatitis were selected and divided into control group (49 cases) and observation group (49 cases). The patients in control group were treated with open surgery, patients in the observation group were treated with laparoscopic surgery.
Results:
The level of the Lym,CD3+ and CD4+ of the patients in the observation group were significantly higher than those of the patients in control group, whereas the level of CD8+ of the patients in the observation group were significantly lower than those of the patients in control group (P <0.01). Furthermore, the level of Ang-Ⅱ,Ang-Ⅲ,ALD of the patients in the observation group were significantly lower than that of the patients in control group (P <0.01) and the level of IL-6,PCT,hs-CRP of the patients in the observation group were significantly lower than that of the patients in control group (P <0.01).
Conclusion:
Laparoscopic treatment of severe acute pancreatitis have obviously effect, advantages of the wound is small, simple and quick recovery, can effectively restore immune function in patients, improve the therapeutic effect, also can improve the quality of life of patients.
2017 Vol. 23 (3): 387-390 [
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391
Study on the Expression of Related Cytokines in the Serum of Patients with Diabetic Retinopathy
ZHANG Yanli, ZHAO Qi, et al
DOI: 10.3969/j.issn.1006-6233.2017.03.013
Objective:
To investigate whether EGF,TGF2β,bFGF,TNF-α,CRP and PEDF affect diabetic retinopathy.
Methods:
Serum EGF,TGF2β,bFGF,TNF-α,CRP and PEDF were detected by ELISA in control, NDR, NPDR and PDR groups.
Results:
The serum levels of VEGF,TGF2β,bFGF,TNF-α,CRP in NDR,NPDR and PDR groups were higher than control group, while PEDF was lower (P<0.05). The serum levels of VEGF,TGF2β,bFGF,TNF-α,CRP in NPDR and PDR were higher than NDR group while PEDF was lower (P<0.05). The serum levels of VEGF,TGF2β,bFGF,TNF-α,CRPin PDR were higher than NPDR group, while PEDF was lower (P<0.05).
Conclusion:
Hyperglycaemia induced VEGF,TGF2β,bFGF,TNF-α,CRP levels and reduced PEDF, which aggravated the pathological changes in retina.
2017 Vol. 23 (3): 391-393 [
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394
Serum Levels of Tumor Markers and Radiotherapy on Serum Levels of PINP and β-CTX in Lung Cancer Patients with Bone Metastasis
ZHU Li
DOI: 10.3969/j.issn.1006-6233.2017.03.014
Objective:
To study the changes of serum BALP, CA125, NSE, CEA and CYFRA21-1 levels in patients with lung cancer bone metastases and the effects of radiotherapy on serum levels of PINP and β-CTX.
Methods:
Thirty-six patients with bone metastases from advanced lung cancer were included in our study. Forty patients with lung cancer without bone metastasis were selected as bone metastases group. BALP, CA125, NSE and CEA were measured in all patients. And CYFRA21-1 tumor markers such as levels. The levels of PINP and β-CTX in the patients with lung cancer bone metastasis before and after radiotherapy were also measured.
Results:
The levels of BALP, CA125, NSE, CEA and CYFRA21-1 in lung cancer patients with bone metastasis were significantly higher than those without metastasis (P <0.05). The level of serum PINP before radiotherapy was higher than that after radiotherapy, and there was significant difference (t = 5.233, P <0.05) (0.56 ± 0.41) ng / mL,which was slightly higher than that after radiotherapy (0.41 ± 0.13) ng / mL, there was no statistically significant difference (t = 1.266, P> 0.05). The level of serum PINP in patients with radiotherapy before radiotherapy was significantly higher than that before radiotherapy (110.13 ± 80.99 ng / mL vs 48.16 ± 18.91 ng / mL, t = 6.029, P <0.05) (0.48 ± 0.32) ng / mL, which was significantly higher than that after radiotherapy (0.29 ± 0.15) ng / mL, and there was significant difference (t = 4.609, P <0.05). The level of PINP in patients with bone metastases from lung cancer before radiotherapy (102.47 ± 78.75) ng / mL was significantly higher than that after radiotherapy (43.29 ± 18.28) ng / mL, and there was significant difference (t = 7.023, P < (0.52 ± 0.34) ng / mL was significantly higher than that after radiotherapy (0.34 ± 0.18) ng / mL, with statistical significance (t = 4.601, P <0.05). There were 11 cases of NR, 12 cases of PR and 13 cases of CR in 36 cases of lung cancer with bone metastatic chemotherapy. The effective rate was 69.44%.
Conclusion:
Combined detection of BALP, CA125, NSE, CEA and CYFRA21-1 in patients with bone metastases of lung cancer is of great clinical significance. In addition, serum PINP and β-CTX are helpful in judging the progression of bone metastasis. Both of them have a good monitoring effect in the evaluation of metastatic radiotherapy, which is of great significance to prolong the survival time of patients with bone metastasis of lung cancer and improve the therapeutic effect.
2017 Vol. 23 (3): 394-397 [
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398
Study on Cognitive Function of Lacunar Cerebral Infarction with Cerebral Leukemia
ZHU Liqin, et al
DOI: 10.3969/j.issn.1006-6233.2017.03.015
Objective:
To study the effect of lacunar cerebral infarction and leukoaraiosis on cognitive function in patients, and to analyze their correlation.
Methods:
A total of 92 patients with lacunar infarction were enrolled in this study from July 2015 to November 2016. The patients were treated with MRI to determine the white matter of the patients. According to the situation of leukoaraiosis, the patients were divided into control group White matter loose) and observation group (with leukoaraiosis), the control group of 34 patients, the observation group of 58 cases. (MoCA) was performed on the cognitive function of the two groups of patients. The cholinergic pathway high signal scale (Chips scale) and the modified Scheltens scale were performed in the observation group. The patients were treated with leukoaraiosis to determine the situation after the analysis of patients with leukoaraiosis and cognitive function of the correlation.
Results:
The scores of MoCA scale showed that the visual acuity and performance score, attention and concentration score and memory score of the observation group were significantly better than those of the control group (t = 3.21,4.59,9.37; P <0.05) The overall score of the scale was also significantly better than the control group (t = 4.24, P <0.05). There was a statistically significant difference between the Chips scale and the modified Scheltens scale in patients with cognitive impairment and cognitive impairment in the observation group (t = 3.81,6.68; P <0.05). Correlation analysis of cognitive impairment in patients with lacunar infarction and leukoaraiosis in patients with leukoaraiosis showed that the visual space and execution of patients, attention and concentration, orientation and total score of MoCA were compared with those of Chips scale (P <0.01). There was a negative correlation between the concentration, the orientation force and the total score of MoCA and the modified Scheltens scale (P <0.05).
Conclusion:
Lacunar infarction with cerebral leukosis is associated with cognitive dysfunction in patients, and the degree of leukoaraiosis in patients is related to the severity of cognitive dysfunction.
2017 Vol. 23 (3): 398-400 [
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401
Effect of Enteral Spray of Kuijieling on the Intestinal Mucosal Immune Function and Levels of Inflammatory Factors in Patients with Ulcerative Colitis
XU Li
DOI: 10.3969/j.issn.1006-6233.2017.03.016
Objective:
To analyze the effect of enteral spray of Kuijieling on the intestinal mucosal immune function and levels of inflammatory factors in patients with ulcerative colitis (UC).
Methods:
Ninety patients with UC were randomly divided into the experimental group (n=45) and the control group (n=45).The control group was treated with oral administration of sulfasalazinecapsule while the experimental group was additionally treated with enteral spray of Kuijieling. The relief of endoscopic ulcer, erosion and bleeding points was observed before and after treatment. The serum immunological and inflammatory factors, including immunoglobulins (IgG, IgM, IgA), T cell subsets (CD4+, CD8+), tumor necrosis factor α(TNF- α), interleukin -1β(IL-1β) were detected.
Results:
The results of endoscopy showed no significant differences between the two groups before treatment (P> 0.05). After treatment, the incidence rates of endoscopic ulcer, erosion and bleeding were significantly decreased (P< 0.05), and the incidence rates in experimental group (4.44%, 11.11%, 8.88%) were significantly lower than those in the control group (17.78%, 28.89%, 24.44%) (P< 0.05). Before treatment, the immunoglobulins, T cell subsetsand levels of serum inflammatory factors showed no significant differences between the two groups (P> 0.05). After treatment, the above indexes were significantly improved (P< 0.05), and the levels of IgG, IgM, IgA, CD8+, IL-4 and IL-10 in the experimental group were significantly higher than those in the control group while the levels CD4+, TNF- α and IL-1β were significantly lower than those in the control group (all P< 0.05).
Conclusion:
Enteral spray of Kuijieling can significantly enhance the clinical therapeutic effect of UC, relieve endoscopic ulcer and erosion, enhance theintestinal mucosal immune function and regulate the levels of inflammatory factors.
2017 Vol. 23 (3): 401-404 [
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405
Different Kinds of Local Anesthetics on Pregnancy Effect in Diabetic Patients after Cesarean Section Neurotoxicity
JIANG Jiduan, LUO Li
DOI: 10.3969/j.issn.1006-6233.2017.03.017
Objective:
To observe the effects of different kinds of local anesthetics in patients with diabetes after cesarean section pregnancy neurotoxicity.
Methods:
90 cases of cesarean section in our hospital from April 2015 to June 2016 were selected as the research object.According to the gestational diabetes mellitus, women were divided into diabetic group (n=45) and non-diabetic group (n=45).The analysis of different kinds of local anesthetics on the two groups after cesarean section occurred neurotoxicity, success rate of nerve block and block duration.And to analyze the impact of species, local anesthetic concentration, dose and duration to maternal neurotoxicity after cesarean section.
Results:
Diabetes group neurotoxicity incidence rate was 86.67%, significantly higher than that of non-diabetic group neurotoxicity incidence was 68.89% (p<0.05);The success rate of nerve block in the diabetic group was 95.55% and that of the diabetic group was less than that in the non-diabetic group (p<0.05). The success rate of nerve block was 82.22% (p<0.05);Types of local anesthetics on small maternal neurotoxicity after cesarean section is relatively better than bupivacaine and ropivacaine, Liddle Kain (p<0.05);The smaller the higher dose of ropivacaine toxicity greater neurotoxicity (p<0.05);The higher the concentration, the greater the neurotoxicity (p<0.05);The longer the duration of action, the greater the neurotoxicity (p<0.05).
Conclusion:
diabetes in pregnancy after cesarean section neurotoxicity of local anesthetics is larger, better effect of local anesthetic nerve block of women with gestational diabetes mellitus.Effect of different kinds and concentration, dosage and time effect of local anesthetics on the neurotoxicity of different clinical attentions.It is necessary to further study, in order to reduce the neurotoxicity of local anesthetics brought by the development prospects for the rational application of local anesthetics.
2017 Vol. 23 (3): 405-407 [
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408
Elderly Patients with General Anesthesia Postoperative Static Note Fluorine Marcie's Influence Cognitive Function and According to Research of Beta Protein Expression
WANG Ting, YELIKEN·Yeerdaolaiti, MIRI Guli, et al
DOI: 10.3969/j.issn.1006-6233.2017.03.018
Objective:
To study the anesthesia in elderly patients with postoperative static note fluorine marcie's influence cognitive function and according to beta protein expression.
Methods:
Chose between April 2015 and March 2016, orthopaedic surgery treated in our hospital 82 cases of elderly patients. According to random number table method was divided into observation group and the control group each had 41 cases. All patients with general anesthesia processing, then the control group was given 5 ml saline intravenous injection, the observation group were given fluorine marcie, 5 ml intravenous injection. Respectively compared two groups of patients bleeding amount of operating time, wake up of time, extubation time, MMSE score, serum according to beta protein levels before and after operation and the OAA/S score before and after injection.
Results:
The observation group of waking time, extubation time, respectively (8.7±3.1) min and (13.1±2.4) min, were significantly lower than in the control group (12.9±2.9) min and (15.8±3.7) min, differences were statistically significant (all P < 0.001). After 6 h, 1 d after operation, postoperative MMSE score 3 d observation group were significantly higher than that of control group, differences were statistically significant (all P < 0.001). 6 h after surgery, postoperative serum according to beta level 1 d observation group were significantly lower than the control group, the difference had statistical significance (P < 0.05). 1 min, 2 min, 5 min after injection of OAA/S score of observation group patients were significantly higher than the control group, the differences were statistically significant (all P < 0.05).
Conclusion:
General anesthesia in elderly patients with postoperative static note fluorine marcie, which can effectively shorten the postoperative patients with waking time, extubation time, at the same time improve patients MMES score, reduce according to beta protein concentration, reducing the occurrence of postoperative cognitive dysfunction in patients.
2017 Vol. 23 (3): 408-411 [
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95
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412
Effect of the Clinical Efficacy and Gastroscopic Histology by Jinghuaweikang Capsules Combined with Mo Luo Dan in the Treatment of Senile Gastritis with Hp Infection
XIE Da
DOI: 10.3969/j.issn.1006-6233.2017.03.019
Objective:
To investigate the effect of the clinical efficacy and gastroscopic histology by Jinghuaweikang capsules combined with Mo Luo Dan in the treatment of senile Gastritis with Hp infection .
Method:
80 senile chronic atrophic gastritis with Hp positive patients from February 2014 to February 2016 in our hospital were selected and randomly divided into two groups. The control group of 40 cases, treated with routine clinical treatment; 40 cases in the experimental group were treated on the basis of the control group with Jinghuaweikang capsules combined with Mo Luo Dan. Observe two groups of patients before and after treatment of Hp eradication rate, gastric mucosal atrophy, intestinal metaplasia, dysplasia and other pathological score, the results using SPSS 19 statistical software for data analysis.
Result:
Compared with before treatment,two groups of patients Gastric mucosal atrophy, intestinal metaplasia and intraepithelial neoplasia levels were higher after treatment.Compared with the control group, the experimental group patients eradication rate of Hp was higher than that of control group, such as gastric mucosal atrophy, intestinal metaplasia and intraepithelial neoplasia lower than the control group, the differences were statistically significant (P < 0.05).
Conclusion:
Jinghuaweikang capsules combined with Luo Dan friction can be effective in the treatment of Hp infection, inhibition of gastric mucosal atrophy, intestinal metaplasia, intraepithelial neoplasia and other pathological changes, and has better clinical efficacy, worthy of clinical application.
2017 Vol. 23 (3): 412-414 [
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255
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415
The Coracoid Method of Suprascapular Nerve Puncture Positioning
ZHU YongJin, LI Ya
DOI: 10.3969/j.issn.1006-6233.2017.03.020
Objective:
To investigate the suprascapular nerve block using the traditional method and the coracoid method of suprascapular nerve block quality, to find a more simple method more accurately, improve the curative effect of suprascapular nerve block.
Methods:
using piecewise randomization, two groups of 43 patients respectively, using the traditional puncture and coracoid method of suprascapular nerve block, confirmed by perspective of C arm, and injection of 0.5% ropivacaine hydrochloride compound analgesic liquid after patients have obvious radiation to the shoulder and scapular region paresthesia, pain disappeared after 10 minutes or significantly reduced, that the success of the block.
Results:
the success rate of 74.4% using the traditional method, the coracoid method success rate was 97.7%, there were significant differences between the groups (P<0.05).
Conclusion:
the traditional method of block success rate is low, because the method does not consider the physical differences, while the proportion of scapula and coracoid process is relatively fixed, so the coracoid method of suprascapular nerve block is a simple and accurate method is obviously superior to the traditional method.
2017 Vol. 23 (3): 415-417 [
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203
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418
Efficacy of Posterior Laminectomy Combined with Cruciate Stick System in the Treatment of Ossification of Posterior Longitudinal Ligament
WANG Ning, ZHANG Xuesong
DOI: 10.3969/j.issn.1006-6233.2017.03.021
Objective:
To investigate the clinical efficacy of posterior laminectomy combined with cruciate ligament system in the treatment of ossification of posterior longitudinal ligament of the cervical spine.
Methods:
50 patients with ossification of the posterior longitudinal ligament of the cervical spine were randomly divided into two groups. The patients in the control group were treated with posterior laminectomy. The patients in the experimental group were treated with staples The curative effect of cervical spine, spinal cord compression, JOA score, overall treatment, complication and treatment satisfaction were compared between the two groups before and after treatment.
Results:
There was a significant difference between the experimental group and the control group (P> 0.05). There was a significant difference between the JOA score group and the control group (P <0.01). There was significant difference between the two groups (P> 0.05). There was significant difference between the two groups (P <0.01). There was significant difference between the two groups (P <0.01) Significantly higher than the control group, the overall incidence of complications was significantly lower than the control group, treatment satisfaction evaluation was significantly better than the control group, there was a significant difference (P <0.05).
Conclusion:
The clinical effect of posterior laminectomy combined with the treatment of ossification of the posterior longitudinal ligament of the cervical spine is significant and has reference significance.
2017 Vol. 23 (3): 418-420 [
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100
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421
Serum Thyroid Hormone Level Change of Chronic Obstructive Pulmonary Disease
GUAN Ruining, ZHOU Mudan, YU Dongzai
DOI: 10.3969/j.issn.1006-6233.2017.03.022
Objective:
To analyze serum thyroid hormone level change of chronic obstructive pulmonary disease and the correlation between the severity of disease.
Methods:
41 cases of patients with chronic obstructive pulmonary disease in remission and 123 cases in exacerbation (including PaO2>60mmHg, 40mmHg<PaO2<60mmHg and PaO2<40mmHg group) from April 2013 to September 2015 in our hospital and 41 cases of healthy people by routine check-up in our hospital during the same period were selected, then the serum thyroid hormone levels were determined.
Results:
Compared with healthy control group, TT3, FT3, TT4, FT4, TSH level in remission group has no statistical difference(P > 0.05), while compared with the rest of the two groups, all indexes in exacerbation group were significantly lower (P < 0.05).And TT3, FT3, TT4, FT4, TSH levels in moderate hypoxia group significantly decreased compared with those in relatively mild hypoxia (P < 0.05). The level of each index in severe hypoxia group significantly decreased compared with the moderate hypoxia group (P < 0.05). There was statistical difference in detection index level between three groups.
Conclusion:
The serum thyroid hormone level of chronic obstructive pulmonary disease is positively correlated with disease severity, level changes are more apparent as the pathological changes, clinical detection is of great significance in lesion severity judgment.
2017 Vol. 23 (3): 421-423 [
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103
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424
Curative Effect of Ultra-early Small Bone Window Minimally Invasive Clear Intracranial Hematoma in Treating Hypertensive Intracerebral Hemorrhage
SUN Lingyun, ZHANG Xiaoqiang, WANG Xiang, et al
DOI: 10.3969/j.issn.1006-6233.2017.03.023
Objective:
To observe the clinic effect of ultra-early small bone window minimally invasive clear intracranial hematoma in treating Hypertensive intracerebral hemorrhage.
Methods:
103 patients with hypertensive cerebral hemorrhage were randomly divided into two groups, the observation group(n=54) were treated by small bone window minimally invasive clear intracranial hematoma, and the control group(n=49) were treated with traditional craniotomy, clinical curative effect of the 2 groups were compared after surgery.
Results:
The total effective rate of observation group was 88.9%, significantly different compared with the control group (71.4%) (P＜0.05); The operation time of the observation group were (33.4±10.8) min, significantly lower than the control group (81.5±34.2) min (P < 0.05); The hematoma clearance rate of two groups respectively (94.3±5.2)%and(87.7±6.5)%, the observation group was significantly higher than the control group (P < 0.05); The hematoma absorption time were (5.4±1.3) d and d (6.9±1.2)d, the hospitalization days were (17.9±6.9)d and(23.3±7.2)d drespectively, observation group was significantly shorter than the control group (P < 0.05); After surgery, neurologic impairment of all patients were improved significantly, but the neurologic impairment score of observation group was significantly lower than control group (P < 0.05);The complication incidence rate of observation group was significantly lower than the control group (P < 0.05), there was no statistically significant difference between the two groups in mortality(P > 0.05).
Conclusions:
Ultra-early small bone window minimally invasive clear intracranial hematoma had good effect and high efficiency to hypertensive intracerebral hemorrhage, patient had good neural functional recovery after surgery, and it also had low complication rate and high security, is worth clinical promotion.
2017 Vol. 23 (3): 424-426 [
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114
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427
Effect of Pingyangmycin Combined with Radiotherapy in the Treatment of Advanced Skin Cancer
FENG Jiatie, ZHANG Lianzhong, DONG Bing
DOI: 10.3969/j.issn.1006-6233.2017.03.024
Objective:
To investigate the clinical effect of pingyangmycinc combined with radiotherapy in the treatment of advanced skin cancer.
Methods:
From January 2012 to January 2016,selected 100 cases of skin cancer in our hospital, the patients were randomly divided into observation group (n=44) and control group (n=56), the observation group were treated with pingyangmycinc combined with radiotherapy, and the control group were treated with radiotherapy, observed the curative effect and adverse reaction of the two groups.
Results:
The short-term curative efficacy of the observation group was significantly better than that of the control group (P < 0.05), the proportion of complete remission (CR) and partial remission (PR) were 50.00% and 34.09%; Observation group 1, 2, 3 year survival rates were 90.70%, 77.90% and 61.20%, the control group 1, 2, 3 year survival rates were 85.20%, 68.10% and 50.40%, the observation group long-term curative effect was significantly better than the control group (P < 0.05); The observation group and the control group nausea and vomiting, leukopenia, stomatitis and alopecia adverse reactions difference were not statistically significant (P > 0.05).
Conclusion:
It is safe and effective for the treatment of advanced skin cancer with pingyangmycinc combined with radiotherapy, which is worthy of clinical application.
2017 Vol. 23 (3): 427-429 [
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112
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430
Correlation Study of the Levels of Uric Acid With Inflammation Factor in Type 2 Diabetes
HE Jianqiu, ZHANG Rui, SUN Zhixin, et al
DOI: 10.3969/j.issn.1006-6233.2017.03.025
Objective:
To investigate the correlation of the levels of uric acid with inflammation factor in type 2 diabetes.
Methods:
One hundred and seven cases of patients with type 2 diabetes were divided into contral group, microalbuminuria group and clinical proteinuria group according to urinary albumin to creatinine ratio, the levels of uric acid and C-reactive protein were detected.
Results:
The levels of uric acid and C-reactive protein,TNF-α,ICAM-1 of contral group, microalbuminuria group and clinical proteinuria group were on the rise, the differences were statistically significant(P<0.05), the levels of uric acid with C-reactive protein,TNF-α,ICAM-1 were positively correlated.
Conclusion:
Uric acid leading to diabetic nephropathy through inflammatory reaction in type 2 diabetes.
2017 Vol. 23 (3): 430-432 [
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109
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433
Analysis of Thyroid Function FT3 FT4 TSH in Gestational
CUI Fengyun
DOI: 10.3969/j.issn.1006-6233.2017.03.026
Objective:
To investigate the dynamic changes of FT3, FT4 and TSH levels in thyroid function during pregnancy, and to investigate the prevalence of thyroid function in women with various stages of pregnancy.
Methods:
A total of 753 pregnant women and 114 normal pregnant women who had undergone pre - pregnancy physical examination and hospital delivery in our hospital between August 2015 and August 2016 were investigated. The serum FT3, FT4, TSH levels were measured by luminescence detection.According to the detection level and the corresponding diagnostic criteria to determine the prevalence of thyroid disease.
Results:
During pregnancy, the FT4 level decreased gradually with the pregnancy cycle prolonged, and there was significant difference in normal physical examination, early pregnancy, mid pregnancy and late pregnancy (F = 9.534, P <0.05); FT3 level (F = 4.968, P <0.05). The level of TSH in pregnant group increased gradually, and there was significant difference between the two groups (P <0.05). There was no significant difference between the two groups There was significant difference (F = 12.398, P <0.05). The prevalence of thyroid disease in pregnant women was significantly higher than that in normal pregnant women (P <0.05). There was no significant difference in the prevalence of thyroid diseases between early and middle stages of pregnancy (P> 0.05) There was significant difference between early and mid-pregnancy (P <0.05).
Conclusion:
The levels of FT3, FT4, TSH in pregnant women have significant changes, and the prevalence of thyroid disease in pregnant women is significantly higher than that in normal women. The incidence of thyroid disease in women in late pregnancy is significantly higher than that in early pregnancy and mid - On the corresponding measures should be taken to prevent and treat.
2017 Vol. 23 (3): 433-435 [
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90
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436
Effect of Auripuncture Tympanic Positive Pressure Lavage and Negative Pressure Drainage for Dry Ear Rate and Other Therapeutic Effects Index of Secretory Otitis Media
WANG Ling, LUO Wei
DOI: 10.3969/j.issn.1006-6233.2017.03.027
Objective:
To study effect of auripuncture tympanic positive pressure lavage and negative pressure drainage for dry ear rate and other therapeutic effects index of secretory otitis media.
Methods:
From August 2012 to August 2014 105 patients (112 ears) with surgical treatment in our hospital were selected as the research object. In accordance with the operation mode divided into observation group (auripuncture tympanic positive pressure lavage and negative pressure drainage) of 51 cases (56 ears) and the control group (tympanic conventional lavage) of 54 cases (56 ears). Followed up for 1 years, the two groups were compared with the near and long-term effects, as well as the treatment of ear related indicators.
Results:
The total effective rate was 94.64% in the observation group, whereas it was 76.79% in the control group(P < 0.05). The dry ear rate of observation group in 3, 6 and 12 months were 94.64%, 96.43% and 96.43%, respectively which were significantly higher than those in the control group (P < 0.05). After treatment, the tinnitus, deafness, hearing loss and the proportion of ear fullness of the two groups were significantly lower, and there was significantly difference between the two groups (P < 0.05).
Conclusion:
Auripuncture tympanic positive pressure lavage and negative pressure drainage in the treatment of SOM has a good short-term and long-term effect and can improve the patients dry ear rate, safety is good, it is worth in clinical promotion.
2017 Vol. 23 (3): 436-438 [
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85
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439
Effect of Different Minimally Invasive Surgery on Adult Patients with Hallux Valgus
YAN Shijie, FU Qiang, HOU Xizhi, et al
DOI: 10.3969/j.issn.1006-6233.2017.03.028
Objective:
To explore the clinical effect of minimally invasive surgery in the treatment of adult patients with hallux valgus.
Methods:
The clinical data of 78 cases of adult patients with hallux valgus treated in our hospital from January 2012 to January 2014 in our hospital were selected as the research object and analyzed retrospectively, of which 13 cases underwent Mayo, 20 cases underwent McBride, 22 cases underwent Keller, 23 cases underwent modified McBride, then the clinical efficacy and gait were analyzed.
Results:
After treated by modified McBride, HVA and IMA level were lower than those by McBride, Keller and Mayo(P<0.05), and the excellent rate of modified McBride (91.30%) was higher than that of Mayo (46.15%), McBride (75%), Keller (81.82%), there was significant difference (P<0.05).
Conclusion:
Modified McBride can be used to correct hallux valgus and restore the thumb flexion and extension ability, improve the clinical efficacy, which is worthy of clinical promotion and application.
2017 Vol. 23 (3): 439-441 [
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95
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442
Comparison of Efficacy of Two Nucleosides for the Treatment of Hepatitis B-Related Cirrhosis Associated with Hepatogenous Diabetes
YANG Jun, et al
DOI: 10.3969/j.issn.1006-6233.2017.03.029
Objective:
To compare the efficacy of entecavir and adefovir dipivoxil for the treatment of hepatitis B-related cirrhosis associated with hepatogenous diabetes.
Methods:
60 patients with hepatitis B-related cirrhosis associated with hepatogenous diabetes were randomly assigned to the entecavir group or adefovir dipivoxil group each including 30 patients.Entecavir group received entecavir tablets 0.5 mg qd,and adefovir dipivoxil group received adefovir dipivoxil tablets 10 mg qd.Patients in both groups were given diabetic diet,blood glucose control with insulin,and liver protection.The two groups were compared for liver function indicators,Child-Pugh score,HBV DNA load,hepatic fibrosis indicators(PCⅢ,Ⅳ-C,LN,HA),and glucose metabolic indicators(FBG and HbA1c)following 48 weeks of treatment.
Results:
Compared to adefovir dipivoxil group,there were significant improvements in liver function indicators,Child-Pugh score,HBV DNA load,hepatic fibrosis indicators,and glucose metabolic indicators following treatment in entecavir group(P<0.05).
Conclusion:
Entecavir could effectively suppress HBV replication,and improve liver function,Child-Pugh score,HBV DNA load,hepatic fibrosis indicators,and glucose metabolic indicators for patients with hepatitis B-related cirrhosis associated with hepatogenous diabetes,with the efficacy superior over adefovir dipivoxil.
2017 Vol. 23 (3): 442-445 [
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96
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446
More Section and Puncture and Section by Puncture Vertebral Plasty Treatment the Curative Effect of Vertebral Osteoporotic Fracture
WANG Duojun, LIU Xiaodong, CAI Feng, et al
DOI: 10.3969/j.issn.1006-6233.2017.03.030
Objective:
To explore the multi section and puncture and by puncture vertebral plasty (PVP) treatment the curative effect of vertebral osteoporotic fracture. Selection
Methods:
From January 2009 to January 2016, our hospital during the period of the PVP treatment of more than 120 patients with vertebral osteoporosis compression fractures (262 knots) vertebral bodies, 60 cases were divided into observation group (134 vertebral) and the control group 60 cases (128 vertebral), the control shall be by piercing into the road, observation group s to puncture into the road at the same time, compared two groups of pain degree, injured vertebral function recovery, average single vertebral operation time, security measures such as surgery.
Results:
Two groups of postoperative VAS pain score the next day and ODI scores were lower than the preoperative (P < 0.05), two groups of postoperative the ODO VAS score, score was no significant difference (P > 0.05).Observation group average single wounded vertebral operation time, average single vertebral perspective times are less than the control group (P < 0.05);Two groups of average single injured vertebrae cement injection dose was no significant difference (P > 0.05).Observation group of bone cement leakage rate was 13.3%, the control group in the incidence of leakage of bone cement was 16.7%, comparing the two groups had no significant difference (P > 0.05).
Conclusion:
For severe vertebral body collapse, multiple class and piercing into the road line PVP treatment vertebral osteoporotic fractures can be obtained more regular by section in the PVP similar clinical curative effect, and can shorten the operation time and the time perspective, and safe operation.
2017 Vol. 23 (3): 446-448 [
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101
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449
Efficacy Comparation of Retroperitoneal Laparoscopic Partial Nephrectomy and Open Partial Nephrectomy for the Treatment of Renal Tumors
FU Shui
DOI: 10.3969/j.issn.1006-6233.2017.03.031
Objective:
To explore clinical efficacy of retroperitoneal laparoscopic partial nephrectomy(LPN) and open partial nephrectomy (OPN) for the treatment of renal tumors.
Methods:
94 patients with renal tumor treated by renal resection in our hospital from October 2015 to October 2016 were selected and randomly divided into retroperitoneal laparoscopic group and open group, 47 cases in each group,observation compared two groups of then the operation time, intraoperative blood loss index, serum creatinine and postoperative complications rate, etc. were observed and compared.
Results:
Intraoperative blood loss, postoperative flow and postoperative hospital stay, postoperative intestinal recovery time, postoperative pain medication dosage in the retroperitoneal laparoscopic group were significantly less than those in the open group (P < 0.05). 3 days after the operation, the serum creatinine level is lower than that in the open group, there was statistical significance (P < 0.05). The postoperative complication rate was 4.3% in the retroperitoneal laparoscopic group, significantly less than 17.0% in the open group, there was statistical significance (P < 0.05).
Conclusion:
The treatment of LPN on stage T1 renal tumors can obtain similar efficacy to OPN, and the operation is more safe and reliable, worthy of clinical application and promotion, but its long-term efficacy still need long-term follow-up study.
2017 Vol. 23 (3): 449-452 [
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80
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489
The Significance of Dynamic Monitoring of the Changes of Cerebrospinal Fluid ADA for the Prognosis of Tuberculous Meningitis
PEI Shuang, et al
DOI: 10.3969/j.issn.1006-6233.2017.02.045
Objective:
To analyze the clinical significance of the relationship between the dynamic changes of cerebrospinal fluid adenosine deaminase and tuberculous meningitis disease outcome.
Methods:
51 patients with tuberculous meningitis with drug treatment of cerebrospinal fluid were dynamicly tested, and statistical comparison of different outcomes before patients and cerebrospinal fluid ADA levels at different time points after treatment.
Results:
In 51 patients, 44 cases (86.27%) were cured, 2 cases (3.92%) died. Cure treatment group from 1 week, CSF ADA levels gradually decline, down to 4.1U / L, adverse outcome cerebrospinal fluid ADA levels decreased slightly after treatment to 6 weeks of treatment, increased to 23.6U / L at 4 weeks of treatment, treatment It remained at a high 25.1U / L level at 6 weeks. From 4 weeks onwards, ADA levels were significantly lower than cure poor outcome group (P <0.05).
Conclusion:
Detection of ADA in cerebrospinal fluid is conducive to the early diagnosis of tuberculous meningitis, the dynamic changes of cerebrospinal fluid levels of ADA to prompt the condition changes, the prediction of disease prognosis and tuberculous meningitis in guiding clinical treatment has an important reference value.
2017 Vol. 23 (3): 489-490 [
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76
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491
Risk Factors of Pulmonary Embolism in Hospitalized Patients with AECOPD Deduced by Non-dominant Factors
LI Junhua, ZHANG Shiguo, CHEN Zhiyong, et al
DOI: 10.3969/j.issn.1006-6233.2017.02.046
Objective:
To investigate the risk factors of pulmonary embolism (PE) in patients with chronic obstructive pulmonary disease (COPD) deduced by non-dominant factors in order to provide the basis for clinical treatment.
Methods:
184 patients with AECOPD deduced by non-dominant factors in our hospital were selected and divided into two groups, 60 patients in pulmonary embolism group and 122 patients in non-pulmonary embolism group. The past disease history, general information, auxiliary examination results, clinical symptoms and COPD severity grading of the two groups were compared. Then the risk factors were analyzed by Logistic regression analysis.
Results:
There was no statistically significant difference in the general information, COPD severity grading, past disease history and clinical symptoms of the two groups (P>0.05).In the pulmonary embolism group, 25.0% patients' bed time was more than one week, 36.67% patients' difference of the two limb circumference was no less than 1cm, 28.33% patients' PCO
2
was no more than 36mmHg, 38.33% patients had deep venous thrombosis, and 98.33% patients' D Dimer was no less than 500μg/L. Compared with the pulmonary embolism group, the indexes of the non-pulmonary embolism group were significantly better than those of the pulmonary embolism group (P<0.05). According to the Logistic regression analysis, the time in bed more than one week, the difference of the two limbs circumference no less than 1cm, and deep venous thrombosis were the three main risk factors for AECOPD deduced by non-dominant factors.
Conclusion:
There are three main risk factors for AECOPD deduced by non-dominant factors including the time in bed more than one week, the difference of the two limbs circumference no less than 1cm, and deep venous thrombosis. The possibility of PE should be paid more attention to in order to avoid misdiagnosis.
2017 Vol. 23 (3): 491-494 [
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91
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495
Clinical Reasonable Application of Anti-tumor Traditional Analysis of the Assessment and Intervention Measures
CHEN Yong, YANG Yan, CHEN Xia, et al
DOI: 10.3969/j.issn.1006-6233.2017.03.047
Objective:
To evaluate the clinical reasonable application of anti-tumor traditional Chinese situation and analyze the intervention measures.
Methods:
Retrospective analysis of oncology 2015 4 ~ 8 months (before intervention) and 4 ~ 8, 2016 (after the intervention) hospital medical records 179 cases each. Statistical analysis of Chinese traditional medicine amount, DDDs and clinical drug use unreasonable situation.
Results:
The intervention before the anti-tumor traditional consumption amount, per capita medical expenses 2.0188 million yuan and 5078.33 yuan respectively, were significantly higher than 1.8874 million yuan, 44.9871 million yuan after the intervention, the difference was statistically significant (P < 0.05). Intervention after injection dosage forms of DDDs compared with before intervention decreased obviously, compared with oral dosage forms before the intervention. After intervention antitumor Chinese patent medicine use not GeLiLv was 11.18% (19/170), 38.24% (65/170), significantly lower than before, the difference was statistically significant (P < 0.05).
Conclusion:
Through effective intervention measures, can significantly reduce the consumption amount of anti-tumor traditional Chinese drug and unreasonable phenomenon, improve the level of hospital of rational drug use.
2017 Vol. 23 (3): 495-497 [
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96
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498
Antimicrobial Resistance of Helicobacter Pylori Eradication in Chengde Area
HAO Xin, LI Jainhui
DOI: 10.3969/j.issn.1006-6233.2017.03.048
Objective:
To investigate the antimicrobial resistance of Helicobacter pylori eradication in Chengde area and to explore the related treatment protocols.
Method:
Gastric mucosa specimens of 1036 cases of patents with Hp infection by endoscopy from March 2014 to December 2016 in Chengde Central Hospital, were cultured for Hp, 448 strains of clinic isolates were obtained, 9 kinds of antibacterial drug susceptibility test were taken to analyze drug resistance.
Result:
The sensitivity of amoxiciuim, amoxiciuim/clavulanute potassium and clarithromycin for the Chengde area's Hp was high, therefore the drug resistance rate was lower.
Conclusion:
Amoxicilln, amoxicilln/clarithromycin and clarithromycin can continue to be the top choice for the eradication of Hp in Chengde area. Tetracycline, furazolidone, levoifloxacin and moxifioxacin can be used as second-line drugs and the remedial treatment or treatment protocols again.
2017 Vol. 23 (3): 498-499 [
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139
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500
Clinical Effect of Neurotropin Injection Combined with Spleen Aminopeptide in the Treatment of Herpes Zoster
CHEN Lili, HE Lei, Qi Haihua, et al
DOI: 10.3969/j.issn.1006-6233.2017.03.049
Objective:
To explore the clinical effect of Neurotropin and spleen aminopeptide oral lyophilized powder in the treatment of herpes zoster.
Methods:
60 patients with herpes zoster at early stage were randomly divided into two groups: treatment group and control group, 30 cases in each group. The control group were given acyclovir for a 0.25 g intravenous drip every 8 hours and cobamamide needle for 1.0 mg intramuscular injection everyday. On the basis of the treatment in the control group, treatment group were given Neurotropin 3.6IU on an intravenousdrip and spleen peptide oral lyophilized powder producing 2 mg by oral a day, the treatment course was 10 days.The pain degree of the patients was assessed by the methods of visual analogue scale (VAS), The sleep quality of the patients was determined by the methods of sleep quality score (QS), VAS and QS score changes the two groups before and after treatment were compared, the improved effect of neuralgia was observed.
Results:
VAS score of the two groups all significantly decreased before and after the treatment, QS score increased significantly, the difference was statistical significant (P < 0.05). VAS score of the treatment group was significantly lower than that of the control group, while QS score of the treatment group was significantly higher than that of the control group, the difference was statistically significant (P<0.001).
Conclusion:
The application of Neurotropin injection combined with spleen peptide on the treatment of herpes zoster at early stage can effectively improve the symptom of neuralgia patients , then consequently improve the life quality of patients.
2017 Vol. 23 (3): 500-501 [
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113
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511
Analysis of Influencing Factors of Sense of Happiness Index in Patients with Systemic Lupus Erythematosus
MA Ling, YE Yali, CAI Yafei
DOI: 10.3969/j.issn.1006-6233.2017.03.053
Objective:
To explore the influencing factors of happiness index in patients with systemic lupus erythematosus (SLE).
Methods:
A total of 76 patients with systemic lupus erythematosus who underwent endocrine therapy in our hospital from November 2014 to October 2016 were investigated by questionnaire. The Influencing Factors of Sense of Well - being in Patients with Systemic.
Results:
The data of 76 patients in this study showed that the average score of well-being index was (10.29 ± 2.28) and the average level was low, 21 patients (27.63%) had moderate (8.36 ± 4.32). The results of Logistic regression analysis showed that: the education level was low, married, and the family economic burden was lower than that of the family (P0.05) Weight, disease recurrence ≥ 2, duration of disease ≥ 2, the degree of disease, low social support are the factors that affect the well-being index.
Conclusion:
Most patients with systemic lupus erythematosus are in the low level of well-being index. In the course of clinical treatment, the patients should be treated according to the actual situation to improve the index of well-being.
2017 Vol. 23 (3): 511-513 [
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115
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514
The Responsibility System for Overall Nursing Mode's Influence on the Prognosis of Sudden Deafness
ZHANG Xuehong, LIANG Xiaowei, BI Jing
DOI: 10.3969/j.issn.1006-6233.2017.03.054
Objective:
To discuss the responsibility system for holistic nursing effect on the prognosis of patients with sudden deafness.
Methods:
Retrospective analysis in January 2010 to December 2013, to the hospital otolaryngology seeing a doctor of nursing clinical data of 152 patients with sudden deafness.
Results:
The responsibility system for overall nursing mode focus on the patient's psychological nursing, emotional regulation, Pay attention to health education, 76 patients recovered 34 cases (44.74%), 19 cases were markedly improved (25.0%), effective in 18 cases (23.68%), 5 cases (6.58%), the total effective rate of 93.42%, satisfaction of 92.4%, Treatment compliance 93.42%,Significantly higher than the traditional nursing mode.
Conclusion:
Responsibility system for sudden deafness patients in the routine drug treatment, the overall nursing on patients with mental, emotional, implement targeted psychological care and health education, actively improve the patient's bad mood, improve the effect of treatment.
2017 Vol. 23 (3): 514-516 [
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100
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524
Clinical Analysis of New Stone Needle Therapy and Conventional Acupuncture Therapy in Elderly Patients with Chronic Lumbar Muscle Strain
BI Jing, et al
DOI: 10.3969/j.issn.1006-6233.2017.03.057
Objective:
To compare the clinical efficacy of new stone needle therapy and conventional acupuncture therapy on chronic lumbar muscle strain.
Methods:
80 elderly patients with chronic lumbar muscle strain chosen from January 2014 to January 2016 in the Affiliated Hospital of Chengde Medical College were divided into observation group of 40 cases (new stone needle) and control group of 40 cases (acupuncture) according to the digital random method. The observation groups were treated once per 5 days, 3 times as a period of treatment, 3 courses of treatment in all. The control groups were treated 20 minutes for one time, once a day, 5 days as a period of treatment, 3 courses of treatment in all. After each course, the efficacy of two groups were compared and analyzed respectively.
Results:
The VAS score of the observation group was significantly lower than the control group, the curative effect was better than the control group after second, third course of treatment, and the difference was statistically significant (<0.05 P).
Conclusion:
The new stone needle therapy has more advantages than conventional acupuncture therapy for patients with chronic lumbar muscle strain.
2017 Vol. 23 (3): 524-525 [
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92
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