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2017 Vol. 23, No. 10
Published: 2017-10-20
1585
Relationship between Serum CRP and PCT Levels and Acute Respiratory| Failure in Patients with Severe Craniocerebral Injury
LIAO Huan, CUI Daming, LI Ming, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.001
Objective:
To study the relationship between serum C-reactive protein (CRP) and procalcitonin (PCT) levels in patients with severe craniocerebral injury and acute respiratory failure.
Methods:
From May 2015 to April 2016, 77 patients with severe craniocerebral injury were selected. According to the results of laboratory examination and clinical features, the patients were divided into acute respiratory failure group (46 cases) and non-acute respiratory failure group (31cases). The levels of serum CRP and PCT were compared between the two groups at 1d, 3d, 5d and 7d after admission, and the specificity, sensitivity and area under the ROC curve (AUC) were compared between CRP and PCT.
Results:
The levels of serum CRP in the two groups were increased at 1d, 3d, 5d and 7d after admission,the level of PCT in the patients with acute respiratory failure was increased at 1d, 3d, 5d and 7d after admission, the levels of serum CRP and PCT in the patients with acute respiratory failure were higher than those in the non-acute respiratory failure group at 1d, 3d, 5d and 7d after admission, there was significant difference between the two groups, between the two groups at different time points (P <0.05). Patients with severe craniocerebral injury using serum CRP, PCT combined detection in parallel and diagnosis of acute respiratory failure specificity of 0.773, the sensitivity was 0.817, and the AUC was 0.873, which was significantly higher than that of serum CRP and PCT alone.
Conclusion:
The levels of CRP, PCT and acute respiratory failure in patients with severe craniocerebral injury are closely related. The combined detection of serum CRP and PCT can improve the diagnostic value of acute respiratory failure in patients with severe craniocerebral injury.
2017 Vol. 23 (10): 1585-1587 [
Abstract
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203
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1588
Study on the Protective Effect of Ganoderma Lucidum Polysaccharides| about Doxorubicin Inducing Myocardial Cell Injury
XU Fan, LI Xiao, LIU Lanfang, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.002
Objective:
To study the protective effects of Ganoderma lucidum polysaccharides on adriamycin induced myocardial injury, and to explore the mechanism of adriamycin induced myocardial cell.
Methods:
Different concentrations of doxorubicin (1, 2, 4, 6μmol/L) with H9C2 were cultured for 6, 12, 24h,then calculated the cell inhibitory rates at different time and concentration;H
9
C
2
cardiac myocytes were cultured with Ganoderma lucidum polysaccharides of different mass concentrations (0, 3.125, 6.25, 12.5, 25mg/L),adding doxorubicin after 1h,observing morphological changes of the cells after 24h,calculating the cell inhibition rate;MCF-7,KB,K562 were cultured with Ganoderma lucidum polysaccharides,adding doxorubicin after 1h,after 48h calculating the cell inhibition rate
Results:
The inhibition rate of 24h was the highest when 2μmol/L was cocultured with cells,25mg/L Ganoderma lucidum polysaccharides can significantly reduce the death of myocardial cells induced doxorubicin, and not reduce the anti-tumor effect of drugs.
Conclusion:
GL-PS has a protective effect on myocardial cells, had no effect on adriamycin inhibit the growth of tumor cells, there is no synergistic effect.
2017 Vol. 23 (10): 1588-1590 [
Abstract
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148
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1591
Clinical Study on Second-generation Tyrosine Kinase Inhibitors in the First-line |and Second-line Treatment of Chronic Myeloid Leukemia
CHEN Heng, JIANG Yuanqiang, SHEN Yunfeng, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.003
Objective:
To investigate the clinical effect of second-generation tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia (CML).
Methods:
A total of 64 patients with CML treated between January 2013 and December 2016 were selected as study subjects and treated with second-generation tyrosine kinase inhibitor (TKI). Among them, there were 41 cases treated with Nilotinib and 23 cases with Dasatinib. In patients treated by TKI, there were 13 cases receiving first-line medication and 51 cases receiving second-line medication. All were followed up for 6 ~ 54 months, median 18 months. The overall complete hematologic remission (CHR) rate, CCyR rate, rate of major cytogenetic response (MCyR), MMR rate, follow-up overall survival rate (OS) and event free survival rate (EFS) were observed; Meanwhile, the responses of first-line and second-line treatment and adverse drug reactions were compared.
Results:
At the end of follow-up, 43 cases continued second-generation TKI treatment, 14 cases died, 2 cases stopped medication, 2 cases were lost to follow up and 3 cases changed the medication regimen; In terms of overall responses to treatment, the rates of CHR, MCyR, CCyR and MMR were 98.44%, 64.00%, 59.37% and 43.75% respectively; In terms of overall survival status, OS and EFS decreased with duration of the disease. The rates of CCyR, MCyR and MMR of first-line treatment were significantly higher than the second-line treatment (P < 0.05); There were no significant differences in the incidence of adverse drug reactions between Nilotinib and Dasatinib (P > 0.05).
Conclusion:
The effect of Nilotinib and Dasatinib second-generation TKI in the treatment of CML is clear. The prognosis is good and safety is better; The effect of second generation TKI first-line treatment is better than second-line treatment in treating CML.
2017 Vol. 23 (10): 1591-1590 [
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138
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1595
Comparison of Locking Plate Fixation and common Anatomical Plate Fixation| in the Treatment of Fracture of Tibial Plateau with |Clinical Efficacy and Quality of life
LIU Luping, LI Weiqiang, CHEN Leijie, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.004
Objective:
To investigate the comparison of locking plate fixation and common anatomical plate fixation in the treatment of fracture of tibial plateau with clinical efficacy and quality of life.
Methods:
82 patients with fracture of tibial plateau from department of orthopedics in our hospital were selected and randomly divided into the control group and the experiment group, 41cases in each group. Two groups were both received limb traction, swelling and rehydration and other conventional treatment methods, epidural anesthesia was performed before operation in the two groups. The experiment group were treated by locking plate fixation and the control group were treated by ordinary anatomical plate fixation. The clinical efficacy, quality of life, joint mobility and postoperative complications were compared.
Results:
Compared with the control group after treatment, the clinical total effective rate were higher in the experiment group, the quality of life and joint mobility were higher. Compared with the control group, the incidence of postoperative complications in control group (9.76%) was higher than that in the experiment group (31.71%).
Conclusion:
Locking plate fixation was higher than that of the normal anatomic plate fixation compared, in tibial plateau fractures treatment of patients with clinical curative effect significantly, effectively improve the quality of life of patients and joint activities is ideal for tibial plateau fractures.
2017 Vol. 23 (10): 1595-1597 [
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134
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1598
Efficacy of Trastuzumab and Ixabepilone in the Treatment |of Advanced Metastatic Breast Cancer
HUANG Renping
DOI: 10.3969/j.issn.1006-6233.2017.10.005
Objective:
To investigate the efficacy of trastuzumab in combination with ixabepilone treatment of advanced metastatic breast cancer.
Methods:
92 patients with HER-2 positive advanced breast cancer patients in our hospital were selected, the control group (45 cases) with trastuzumab treatment, study group (47 cases) with trastuzumab combined with ixabepilone treatment. The clinical efficacy was compared between the two groups.
Results:
After treatment, the total effective rate of treatment group was significantly higher than the control group, the difference was statistically significant (P < 0.05); For the disease control rate of two groups, disease control rate of study group was significantly higher than the control group, the difference was statistically significant (P < 0.05); For the patients of two groups before treatment, the level of serum tumor markers in comparison, no statistically significant difference (P > 0.05); after treatment, patients with serum levels of tumor markers of two groups were lower than before treatment; compared with the group before treatment, the difference was statistically significant (P < 0.05); while the serum tumor research after treatment the levels of markers was significantly lower than the control group, the difference was statistically significant (P < 0.05); There was no statistically significant difference in adverse reaction rates between the two groups (P > 0.05).
Conclusion:
Trastuzumab combined with ixabepilone for patients with metastatic breast cancer can reduce the CEA, CA125 and CA15-3 levels, and drug safety, has clinical value.
2017 Vol. 23 (10): 1598-1601 [
Abstract
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119
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1602
Controlled Research of the Treatment of the Malignant Biliary |Obstruction Jaundice by Percutaneous Transhepatic Route and the |Duodenoscopic Approach Biliary Stent Placement
HUANG Renping
DOI: 10.3969/j.issn.1006-6233.2017.10.006
Objective:
To investigate the clinical efficacy of the treatment of malignant biliary obstruction jaundice by percutaneous transhepatic route and duodenoscopic approach biliary stent placement.
Methods:
110 patients with malignant biliary obstructive jaundice from December 2013 to March 2015 accepted in our hospital, were divided into experimental group and control group by the random number table method, 55 cases in each group. After admission to hospital, patients in the two groups before operation were given hepatoprotective, diuretic and anti infection etc., improve the patient's general condition. Patients in the experimental group were treated by percutaneous transhepatic biliary stent implantation, and the control group were treated by endoscopic biliary stent implantation. The levels of total bilirubin (TB), direct bilirubin (DB), indirect bilirubin (IB), the average survival period, complication rate and total efficiency of the treatment between the two groups before and after treatment were observed and compared. after treatment.
Results:
After treatment, compared with before treatment, the TB, DB and IB levels were decreased, the difference was statistically significant (P < 0.05); Compared with the control group, TB, DB, IB levels were lower in patients of the experimental group than that in control group, the difference was statistical significance (P < 0.05); Compared with the control group, postoperative average survival period was longer in patients of the experimental group than that in control group, the difference was statistical significance (P < 0.05); Compared with the control group, the incidence of complications in patients of the experimental group were lower, clinical effective rate was higher, and the difference was statistically significant (P < 0.05).
Conclusion:
The clinical efficacy of the percutaneous transhepatic route in the treatment of malignant biliary obstruction is better than duodenoscopic approach biliary stent placement, more conducive to reduced levels of bilirubin, prolong the survival of patients, improve the treatment efficacy.
2017 Vol. 23 (10): 1602-1604 [
Abstract
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131
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1605
The Relationship between CRP and LDL Levels with Microvascular Lesions| and Glucose Metabolism in Diabetic Patients
CHEN Fan, FENG Pu
DOI: 10.3969/j.issn.1006-6233.2017.10.007
Objective:
To study the relationship between the levels of CRP and low density lipoprotein and the degree of microvascular disease and glucose metabolism in diabetic patients.
Methods:
Forty patients with diabetes mellitus with vascular disease and 40 diabetic patients without vascular complications were enrolled in our hospital from Jan. 2015 to Jan. 2017 as subjects. All the patients were divided into two groups, namely 40 patients with diabetes mellitus with diabetes mellitus as the control group and 40 patients with diabetes without vascular complications were observed. The CRP levels and low-density lipoprotein levels were measured and compared between the two groups.
Results:
According to the degree of patients' disease, the patients were divided into two kinds: one, two kinds and three kinds of vascular diseases. The CRP levels of the three groups were measured and the number of vascular lesions was found. The lower the CRP level was, the difference was statistically different P <0.05). The CRP level of the control group was measured and compared with that of the control group (P <0.05), and the difference was statistically significant (P <0.05). The level of the low density lipoprotein was lower. The levels of CRP in the observation group were significantly higher than those in the control group (P <0.05). Low-density lipoprotein levels were measured in the control group and compared with the low-density lipoproteins in the observation group. The CRP level in the observation group was significantly higher than that in the control group (P <0.05).
Conclusion:
The levels of CRP and LDL in diabetic patients are closely related to the degree of microvascular disease.
2017 Vol. 23 (10): 1605-1608 [
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131
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1609
Tiotropium Combined with Respiratory Exercises on Pulmonary |Ventilation Function Quality of Life and Exercise Tolerance |in Patients with COPD
ZOU Dongxia, WANG Xianming, ZHANG Ying, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.008
Objective:
To investigate the effects of tiotropium combined with respiratory exercises on pulmonary ventilation function, quality of life and exercise tolerance in patients with chronic obstructive pulmonary disease (COPD).
Methods:
80 patients with COPD enrolled from July 2015 to December 2016 were randomly divided into two groups. The patients in the control group were treated with tiotropiumamine. The patients in the experimental group were treated with respiratory exercises and compared the patients before and after treatment lung function, exercise endurance, dyspnea, quality of life and poor clinical events.
Results:
Compared with the control group, the levels of FVC, FEV1, FEV1 / FVC, FEV1, MMEF and PEF were significantly higher in the experimental group than those in the control group. Compared with the control group, the 6MWD levels were significantly higher than those in the control group (P <0.05) .Conclusion: Compared with the control group, there was significant difference in the incidence of overall adverse clinical events between the two groups (P> 0.05). The difference between the two groups was statistically significant (P <0.05) P <0.01).
Conclusion:
The effect of tiotropium combined with respiratory exercises on lung ventilation function, quality of life and exercise tolerance of patients with COPD is significant and safe, which is of great significance.
2017 Vol. 23 (10): 1609-1611 [
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111
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1612
Effect and Safety of Dexmedetomidine Combined with Morphine in |Epidural Analgesia after Cesarean Section
CHEN Kunming, JIAO Xiangxue, CONG Zihong
DOI: 10.3969/j.issn.1006-6233.2017.10.009
Objective:
To investigate the clinical effect and safety of dexmedetomidine combined with morphine epidural analgesia after cesarean section.
Methods:
From January 2014 to September 2015, 60 cases with cesarean section were randomly divided into 2 groups, each with 30 cases. After cesarean section, the control group was injected with morphine 1 mg by epidural tube, and the patients in the study group were injected with morphine 1 mg+ and 1 g/kg by dexmedetomidine. The postoperative analgesia and sedative effect of the two groups were observed and compared. The changes of MAP fluctuation, SpO
2
, heart rate, nausea and vomiting, urinary retention, pruritus and chills in the two groups were compared.
Results:
The analgesic and sedative effects of the two groups were evaluated. After surgery 2h, 4h, 8h, 24h the pain classification and Ramsay score at all stages of improvement of the study group were better than the control group (P < 0.05), the difference was statistically significant. There were 2 cases of nausea and vomiting, 1 case of urinary retention, 2 cases of skin pruritus and 1 case of shivering, and the incidence of adverse reactions was 20% in the study group. The study group was obviously better than the control group (P < 0.05), the difference was statistically significant(P＜0.05).
Conclusion:
After the cesarean section analgesia, the combination of dexmedetomidine can achieve satisfactory analgesic and sedative effect, and the rate of adverse reactions is low, which provides a good clinical basis for the rational use of drugs in women.
2017 Vol. 23 (10): 1612-1614 [
Abstract
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132
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1615
Effect of Laparoscopic Resection of Pancreatic Body and Tail on |Splenic Immune Function and Blood Supply in Spleen
DING Bing, JIANG Hui
DOI: 10.3969/j.issn.1006-6233.2017.10.010
Objective:
To investigate the effect of laparoscopic resection of pancreatic body and tail on splenic immune function and blood supply in spleen.
Methods:
The clinical data of 80 cases underwent splenectomy and pancreatic body resection were retrospectively analyzed. The changes of immune function and the blood supply of spleen after open pancreatectomy and laparoscopic resection of pancreatic body and tail were compared.
Results:
The levels of IgG and CD4
+
and CD8
+
T cells in the two groups were lower than those before operation (P<0.05). The level of IgG in the observation group after 1 days was higher than that in the control group, and the scores of CD4
+
and CD8
+
T cells were lower than those of the control group (P<0.05). Two groups of patients had postoperative arteriovenous patency decreased (P<0.05); In the postoperative, the observation group patients arteriovenous patency was significantly higher than the control group (P<0.05). After 1 month, the spleen perfusion in the observation group was significantly better than that in the control group (P<0.05).
Conclusion:
The short-term prognosis of laparoscopic pancreatic body and tail resection is better than that of laparotomy group, and has less influence on the immune function.
2017 Vol. 23 (10): 1615-1618 [
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128
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1619
Efficacy and Impact of Micro-coils for Cerebral Aneurysms of Daily Living
LI Donghua, LI Mi, LI Hailong, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.011
Objective:
To investigate the effect of micro-coils for treatment and the incidence of complications of cerebral aneurysms.
Methods:
A retrospective analysis in August 2014 - February 2016 the clinical data in our hospital coil thrombolytic therapy in patients with cerebral aneurysms, and Guglielmi micro spring according to the treatment used in the process of divided differences microcoil ring set and mechanical detachable microcoil groups. Observation of the therapeutic effect of two groups of patients, NIHSS score, differences in activities of daily living, the incidence of complications.
Results:
Mechanical detachable microcoil group recanalization rate was 86.2%; Guglielmi microcoil group recanalization rate Guglielmi microcoil group, there was no significant difference between the two groups (P> 0.05); Two groups of patients before treatment NIHSS score was no significant difference after treatment, both groups of patients with NIHSS scores than those before treatment (P <0.05); After treatment of eating, bathing, modification, dressing and other activities of daily living score was no significant difference (P> 0.05); Guglielmi detachable microcoil aneurysm patients and then broke, coil prolapse and cerebral vasospasm were significantly lower than mechanical detachable microcoil group, the difference was statistically significant (P <0.05).
Conclusion:
Guglielmi detachable coils and micro-mechanical detachable microcoil of cerebral aneurysms have a better therapeutic effect, and Guglielmi detachable microcoil complication rate, with better clinical value.
2017 Vol. 23 (10): 1619-1622 [
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115
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1623
Preoperative Nutritional Screening Results of MNA-SF and NRS2002 in 242 Elderly| Patients with Colorectal Cancer and Their Relationship with Prognosis
LI Min, QI Fengxia, JU Kai, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.012
Objective:
To analyze the preoperative nutritional screening results of the Mini Nutritional Assessment Short Form(MNA-SF) and nutritional risk screening 2002 (NRS2002) in 242 elderly patients with colorectal cancer and their relationship with prognosis.
Methods:
MNA-SF and NRS2002 were used to evaluate the nutritional status of 242 elderly patients with colorectal cancer before operation. The relationship between the evaluation results and the clinical prognosis was analyzed, and the value of the two nutritional screening tools was compared.
Results:
There were 120 cases (49.59%) in MNA-SF nutritional risk group and 122 cases (50.41%)in MNA-SFnormal nutrition group while there were 99 cases (40.91%) in NRS2002 nutritional risk group and 143 cases (59.09%) in NRS2002 normal nutrition group, without significant difference (P>0.05). The consistent rate of test was 91.32%. The nutritional risk screened by MNA-SF and NRS2002 was related to age, course of disease, intestinal obstruction, differentiation degree, TNM stage and lymph node metastasis. 18 patients received nutritional support, including 16 cases (13.33%%) in MNA-SF nutritional risk groupand 1 case (0.82%) in MNA-SFnormal nutrition group, 18 cases (18.18%) in NRS2002 nutritional risk group. The incidence rates of complications in MNA-SF and NRS2002nutritional risk groupwere higher than those in normal nutrition groups, the hospitalization time was longer than that of normal nutrition groups, postoperative recurrence rate and mortality rate were higher than those of normal nutrition groups, with statistically significant differences (P<0.05). There was a statistically significant difference in the length of hospital stay between the MNA-SF nutritional risk group and the NRS2002 nutritional risk group(P> 0.05).
Conclusion:
MNA-SF and NRS2002 are of high guidance value in preoperative nutritional risk screening for elderly patients with colorectal cancer, and both of them are suitable for clinical nutritional risk screening.
2017 Vol. 23 (10): 1623-1628 [
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208
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1629
Comparison of the Value of ABCD2 Score Combined with TCD or MRA |in the Recent Occurrence of Cerebral Infarction in TIA
LI Qing, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.013
Objective:
To compare the value of ABCD2 score combined with transcranial Doppler (TCD) or magnetic resonance angiography (MRA) in the recent development of cerebral infarction in patients with transient ischemic attack (TIA).
Methods:
70 patients with TIA hospitalized in the department of neurology of our hospital from June 2015 to June 2017 were given ABCD2 score, 40 patients underwent TCD, and 30 patients underwent MRA. Cranial MRI examination was performed within 7 days of onset of TIA, the incidence of cerebral infarction was evaluated.
Results:
Among the 70 patients, 42 cases were ABCD2 scoring low-risk patients. The incidence of cerebral infarction was 4.76% . Among the 20 patients with moderate risk, the incidence of cerebral infarction was 45%. High-risk patients were 8 cases, the incidence of cerebral infarction was 62.50%. The incidence of cerebral infarction in high-risk group and high-risk group was significantly higher than that in low risk group (P<0.01), and there was no significant difference in the incidence of cerebral infarction between the 2 groups (P>0.05). ABCD2 score combined with TCD or MRA on TIA patients with recent cerebral infarction occurred under the diagnostic curve area AUC were 0.848 and 0.654, and the difference between the two tests was statistically significant (Z=2.43, P=0.015). Multivariate logistic regression analysis showed that hypertension, LDL≥2.6mol/L, symptom duration ≥60 min were positively correlated with cerebral infarction formation within 7 days after TIA.
Conclusion:
ABCD2 score has a good predictive value for short-term cerebral infarction in TIA. Compared with TCD, ABCD2 score combined with MRA can improve the accuracy of predicting the risk of cerebral infarction.
2017 Vol. 23 (10): 1629-1631 [
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102
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1632
Clinical Efficacy of Zirconia All-ceramic Crown Restoration |in Gingival Crevicular Fluid
GUO Bin, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.014
Objective:
To study the clinical effect of zirconia all-ceramic crown repair on gingival crevicular fluid.
Methods:
A total of 110 patients who underwent coronary resuscitation from October 2013 to September 2016 were enrolled in this study. The patients were randomly divided into two groups: The patients in the observation group were treated with zirconia all-ceramic crowns, while the control group was coated with cobalt-chromium alloy for crown repair, gingival color, bleeding index and plaque index were recorded. The levels of AST and ALP were detected by Beckman Kurt AU5800 automatic biochemical analyzer. The detection of TNF-α and IL-6 was carried out by ELISA, and the PCR products were used to analyze Haemophilus influenzae, Porphyromonas gingivalis, Trichoderma spp. and Pseudomonas sp. were detected.
Results:
Compared with before treatment, the levels of PD, BI and PLI were increased in the two groups, and the increase of the patients in the observation group was lower than that in the control group. Before treatment, AST, ALP, TNF-α and IL-6 in the observation group were significantly higher than those in the control group. The levels of AST, ALP, TNF-α and IL-6 were significantly higher than those before treatment. The detection rate of Aa, Pg, Tf, Fn and Td in the subgingival plaque specimens of the observation group was lower than that of the control group. The difference between the two groups was statistically significant (P<0.001).
Conclusion:
The effect of zirconia all-ceramic crown on the periodontal effect is small, and it can effectively reduce the levels of AST, ALP, TNF-α and IL-6 in gingival crevicular fluid, and can also reduce the subgingival pathogens Of the detection rate, excellent clinical results.
2017 Vol. 23 (10): 1632-1635 [
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135
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1636
Observation on the Effect of Intraoperative Recurrent Laryngeal |Nerve Exposure on Postoperative Complications |in 127 Patients Undergoing Thyroid Operation
HENG Xing, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.015
Objective:
To observe the effect of recurrent laryngeal nerve exposure on postoperative complications in 127patients undergoing thyroid operation.
Methods:
127 cases of patients who underwent thyroid operation in our hospital from September 2011 to September 2015 were selected and randomized into observation group and control group. 67 patients in the control group did not exposed the recurrent laryngeal nerve in operation while 60 cases in the observation group exposed the recurrent laryngeal nerve in operation. The operation time, intropaerative blood loss, length of hospital stay and other operation indexes and the incidence of postoperative complications were compared between the two groups.
Results:
The operation time of the observation group [(106.31±13.48) min] was significantly longer than that of the control group [(95.61±12.82) min] (P < 0.05); The incidence of postoperative complications in the observation group (4.47%) was lower than that in the control group (18.33%) (P < 0.05).
Conclusion:
The time of intraoperative exposure of recurrent laryngeal nerve in patients undergoing thyroid operation is relatively longer, but it can effectively reduce the incidence of postoperative complications and reduce the pain of patients. It is of application and promotion value in thyroid operation in the future.
2017 Vol. 23 (10): 1636-1637 [
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141
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1638
Effect of Oral Orthodontic Reconstruction Combined with Kangfuxin Liquid |in Treating Wrong Jaw Deformity and Its Effect on RANKL| and OPG in Gingival Crevicular Fluid
HU Fang, LUO Jun, TIAN Wei
DOI: 10.3969/j.issn.1006-6233.2017.10.016
Objective:
To study the effect of oral orthodontic reconstruction combined with Kangfuxin liquid in the treatment of wrong jaw deformity and its effect on RANKL and OPG in gingival crevicular fluid.
Methods:
78 patients with wrong jaw deformity were choosen in our hospital from August 2015 to July 2016, those patients were divided into observation group and control group according to the order of admission. The control group used oral orthodontic reconstruction, the observation group were given Kangfu new liquid on the basis of control group to complete the treatment. The clinical efficacy, toothache degree, gingival crevicular fluid RANKL, OPG levels and adverse reactions were compared between the two groups.
Results:
The total effective rate of the observation group was significantly higher than that of the control group [92.31% (36/39) vs 66.67% (26/39)] (P <0.05). The degree of toothache in the observation group was significantly better than that in the control group (P <0.05). The level of RANKL in the gingival crevicular fluid was significantly lower than that in the control group [(45.87 ± 4.12) ug / L VS(84.86 ± 8.32) ug / L] (P <0.05), and the OPG level was significantly higher than that in the control group [(275.32 ± 21.56 ) Ug / L VS(135.98 ± 11.43) ug / L] (P <0.05). There was no significant difference in the adverse reaction rate between the observation group and the control group [(23.08% (9/39) vs 28.21% (11/39)] (P >0.05).
Conclusion:
Oral orthodontic reconstruction combined with Kangfenxin solution can effectively reduce the concentration of RANKL in gingival crevicular fluid, increase the concentration of OPG, alleviate the pain of patients, and have good clinical curative effect.
2017 Vol. 23 (10): 1638-1641 [
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147
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318
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1642
Analysis on Factors of Deep Infection of Lumbar Spinal Stenosis after |Pedicle Screw Fixation and Treatment Measures
LIU Zhipeng, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.017
Objective:
To explore the related factors of deep infection of lumbar spinal stenosis after pedicle screw fixation and treatment measures.
Methods:
1244 cases of patients treated with pedicle screw fixation due to umbar spinal stenosis in our hospital from April 2011 to April 2016 were selected as the study objects. Single factor and multiple Logistic regression analysis were applied to analyze the related factors of deep infection of lumbar spinal stenosis after pedicle screw fixation.
Results:
In the study, 11 cases of patients with deep infection from 1244 cases of patients were detected, and 19 strains of pathogens were isolated. Of them, 9 strains were gram positive bacteria (47.37%), 10 strains were gram negative bacteria (52.63%), in which staphylococcus aureus accounted for the highest proportion (44.44%). There were on relations between patients' gender, antibiotic use time and the incidence of deep infection (P > 0.05). Single factor analysis showed factors like age more than 65, operation time more than 100 min, intraoperative blood loss more than 500ml, basic diseases or not, postoperative drainage time less than 2d, and BMI > 30 kg/m2 were closely related to the incidence of deep infection (P< 0.05). Multiple Logistic regression analysis showed independent risk factors were age, operation time, bleeding volume and BMI to induce deep infection (P< 0.05).
Conclusion:
There are many factors inducing deep infection, and the hospital should do well in perioperative nursing care in order to prevent deep infection.
2017 Vol. 23 (10): 1642-1645 [
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1646
The Relationship between Peripheral Blood T Lymphocyte Subsets| Serum Adiponectin Levels and the Effect of Hormone Therapy| in Patients with Nephrotic Syndrome
ZHU Lei, XIE Deqiong, ZHANG Chengli, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.018
Objective:
To investigate the relationship between peripheral blood T lymphocyte subsets(Treg), serum adiponectin (APN) levels and the effect of hormone therapy in patients with nephrotic syndrome.
Methods:
80 cases of primary nephrotic syndrome patients were selected during May 2014 to May 2016 in our hospital.35 healthy volunteers as control group, all patients were detected in the serum adiponectin level in patients with T cell subsets and serum in all patients using standard hormone treatment, serum T cell subsets and serum lipid in the association between hormone levels and treatment effect and prognosis of patients with hormone.
Results:
The levels of peripheral blood Treg cells in patients of the observation group was 4.25±1.32,which significantly lower than that in patients of the control group; The levels of APN, T helper cell 17 (Th17) and the ratio of Th17/Treg cells were 33.6±12.5 mg/L, 1.63± 0.26, 0.51 ± 0.07, which significantly higher than that in the control group (P<0.05). Patients were divided into low and high levels of hormone-sensitive therapy based on the numbers of Treg cells, and the results showed 38 cases of patients in the low-level group and 42 cases in high level group. Of them, 19 cases (50%) and 26 cases (61.90%) in the low-level and high-level groups respectively, were sensitive to hormone therapy. Patients were divided into low-level and high-level groups based on the median of serum APN and the results showed 39 and 41 cases of patients that sensitive to hormone therapy. Of them, 19 cases (48.70%) and 26 cases (63.41%) in the low-level and high-level groups respectively, were sensitive to hormone therapy. The difference was not statistically significant, P>0.05.
Conclusion:
The number of Treg cells and serum adiponectin levels were closely related to the effect of hormone therapy.
2017 Vol. 23 (10): 1646-1648 [
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101
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1649
The Effect of Early Combined Therapy on Surgical Treatment |of Old Femoral Shaft Fracture
HOU Jiguang, ZHANG Nan, LUO Shi, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.019
Objective:
To study the effect of orthopedic surgeon, rehabilitation physician and nursing joint on the function of knee joint in the early stage of femoral shaft fracture, and to observe the effect of early done of functional exercise therapy.
Methods:
Patients with femoral shaft fractures were randomly divided into two groups. One group was treated with combination therapy group, orthopedic surgeon and physician, rehabilitation group and nursing treatment. The bone traction was performed in time and early knee function exercise. The other group for the control group, orthopedic surgeon after traction treatment income should be prior to the emergency treatment of general, chest, neurosurgery and other departments, to be stable after the transfer into orthopedic surgery. According to the inclusion criteria, each group collected 30 cases. The age of the two groups, the timing of operation, the time of operation, the shortening of femur, and the knee knee flexion function were recorded and statistically analyzed.
Results:
There was no significantly difference in the age and operation time between the two groups. The operative time and the number of femoral shortening in the combined group were significantly lower than those in the control group. The active flexion range of the knee joint was better than that of the control group at 3 months after operation.
Conclusion:
Early combination therapy, preoperative knee functional therapy, standardized traction, more favorable surgical treatment of old femoral shaft fractures, is conducive to the recovery of better knee function.
2017 Vol. 23 (10): 1649-1651 [
Abstract
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109
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1652
Effects of Ulinastatin Combined with Xuebijing and Anti-tuberculosis drugs on| Arterial Blood Gas and Lactate Clearance in Patients with Pulmonary |Tuberculosis Complicated with Acute Respiratory Distress Syndrome
ZHANG Wenming
DOI: 10.3969/j.issn.1006-6233.2017.10.020
Objective:
To investigate the effects of ulinastatin combined with Xuebijing and anti tuberculosis drugs on arterial blood gas and lactate clearance in patients with pulmonary tuberculosis complicated with acute respiratory distress syndrome .
Methods:
60 pulmonary tuberculosis patients with acute respiratory distress syndrome in our hospital were selected and randomly divided into the control group and the experiment group with 30 cases in each group.Patients in control group were treated with antituberculosis drugs and xuebijing;the experiment group was treated with Ulinastatin Injection on the basis of the control group. After treatment, the clinical efficacy, arterial blood gas, inflammatory factors (IL-1, CPR, TNF-α, PCT) and blood lactate clearance rate of two groups were compared.
Results:
The effective rate of the treatment group was 93.33%, which was higher than that of the control group 73.33% (P < 0.05) ; Compared with before treatment, the PaO2, blood lactate clearance rate increased, the PaCO2 decreased after treatment(P < 0.05);Compared with the control group, the PaO2, blood lactate clearance rate was higher, the PaCO2 level was lower (P < 0.05); After treatment, the serum levels of IL-1, CPR, TNF-α and PCT were controlled in the two groups, and the levels of serum IL-1, CPR, TNF- and PCT in the experiment group were lower than those in the control group (P < 0.05).
Conclusion:
The combined application of ulinastatin Injection and xuebijing and anti-tuberculosis drugs can effectively improve pulmonary tuberculosis complicated with acute respiratory distress syndrome in patients with the effective rate of treatment. It can improve the respiratory circulation, promote the recovery of pulmonary function, arterial oxygen content adjustment, the mechanism might be related to lung function, improve blood gas levels, improve blood lactate clearance rate increased and decreased inflammatory factor IL-1, CPR, TNF- alpha, PCT concentration.
2017 Vol. 23 (10): 1652-1656 [
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130
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1657
Risk Factors of Penetrating Demyelinating Syndrome |after Severe Traumatic Brain Injury
JIN Tao, YE Xin, WANG Bei
DOI: 10.3969/j.issn.1006-6233.2017.10.021
Objective:
To analyze the risk factors of penetrating demyelinating syndrome after severe traumatic brain injury, and to provide reference for clinical prevention and treatment.
Methods:
Retrospective analysis of clinical data from March 2011 to March 2016 in our hospital of 450 cases of severe craniocerebral trauma patients, according to whether the occurrence of osmotic demyelination syndrome (ODS) were divided into ODS group and non ODS group, compared two groups of patients with gender, age, admission damage degree (GCS score), associated injuries, cerebral contusion and the brain, skull fracture, hypotension, traumatic subarachnoid hemorrhage, hematoma, difference of mannitol dosage index.
Results:
450 cases of patients with severe traumatic brain injury in the occurrence of osmotic demyelination syndrome in 11 cases, the incidence rate of 2.44%; Single factor analysis showed that the age of the ODS group was significantly higher than the control group, severe injury, injury, hypotension, cerebral hernia, brain contusion, hematoma was significantly higher than non ODS group (t=9.584, χ
2
=4.877~9.584, P<0.05); Multi Logistic regression analysis showed that age, GCS score (3-8), cerebral contusion, hematoma clearance, hypotension for severe brain tallage risk factors after osmotic demyelination syndrome (β=0.032~0.754, S.E= 0.007~0.302, Wald = 5.324~28.302, P<0.05).
Conclusion:
The osmotic demyelination syndrome with age and severity of injury, injury type and other factors related to severe traumatic brain injury, we should strengthen the prevention of risk factors, reduce the incidence of osmotic demyelination syndrome.
2017 Vol. 23 (10): 1657-1660 [
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91
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1661
The Curative Analysis and Value Evaluation of Immediate Implantation| and Aesthetic Repair in the Traumatically Area
CAO Jianqiang, WANG Lifang, TIAN Biyuan, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.022
Objective:
To observe the curative effect of immediate implantation and aesthetic repair in the traumatically area and evaluate the clinical value.
Methods:
Thirty-two patients visited department of oral implantology, People's Hospital of Handan from June 2014 to June 2016 were given immediate implantation (50 tooth). The injured teeth were planted immediately, and some patients underwent bone regeneration during the same period, and the final restoration was performed 3 months later. After 1 years of follow-up, the success rate of implant was analyzed, the red and white aesthetic index and gingival papilla index were analyzed, and the marginal bone level was measured.
Results:
The implantation success rate was 100%. 1 weeks after the completion of the restoration, the total score of white aesthetics (7.22 ±1.16) was measured and counted; and the soft tissue was recovered well; the gingival papilla did not flinch. As the implantation time increased, the scores of red aesthetics increased accordingly. 12 months after the repair, compared with 1 weeks after the repair and 6 months after the repair, the difference was significant (P<0.05). Compared with 1week and 6 months after the repair, the difference of the marginal bone level of the repair after 12 months was significant (P<0.05) difference.
Conclusion:
The immediate implant can slow the absorption of soft tissue surrounding the implant, shorten the course of the patient's treatment, and achieve higher aesthetic satisfaction, which is worthy of clinical promotion.
2017 Vol. 23 (10): 1661-1662 [
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136
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1663
A Study of the Association between Polymorphisms of the MMP-9 Gene |and type 2 Diabetic Retinopathy
YANG Jie, MA Yinghui, DONG Weili, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.023
Objective:
To study of the association between polymorphism of the MMP-9 gene(-1562C/T)and type 2 diabetic retinopathy.
Methods:
MMP-9 -1562C/T SNP was genotyped by polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) ,analysis in 180 healthy persons as control and 400 patients with type 2 diabetes including 180 complication-free cases and 220 with diabetic retinopathy (DR).
Results:
Association between the MMP-9 -1562C/T SNP in promoter region and diabetic retinopathy: the C and T allele frequencies in Control, DM, DR groups are 8.3%,91.7%; 7.8%, 92.2%; 91.4%, 8.6% respectively. And the results have a significant deviation (χ
2
=790.09,P=0.000). The C/C, C/T , T/T genotypic frequencies of cases in the three groups are 0%,16.7%,83.3%;2.2%,11.1%,86.7%;84.1%,14.5%,1.4%.There's a significant deviation of C and T allele frequency of MMP-9 -1562C/T between the Control group、the DM group and DR group(χ
2
=470.16,P=0.000).There's a significant deviation of C/C,C/T,T/T genotypic frequencies between the Control group and DM group(P<0.01),or the DM group and DR group(P<0.01),while there is no significant deviation between the Control group and DM group(P>0.01) .Compared with the T allele, the C allele may increase the onset risk of diabetic retinopathy.
Conclusion:
The MMP-9 -1562C/T SNP may play a role in the genetic susceptibility to the invasion of diabetic retinopathy. T allele is a protective gene for diabetic retinopathy.
2017 Vol. 23 (10): 1663-1666 [
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135
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1667
Study on the Effect and Mechanism of Injection of Raltitrexed on |Cancer Cells in Gastric Cancer Patients
MA Shihua, SHI Nengsheng, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.024
Objective:
To investigate the effect and mechanism of injection of raltitrexed on cancer cells in gastric cancer patients.
Methods:
84 nude mice were purchased to establish the human gastric cancer cell MGC-803 subcutaneous tumormodel,after successful modeling ,micewere randomly divided into 3 groups, the conventional group received intraperitoneal injection of saline, the raltitrexed group were given intraperitoneal injection of raltitrexed, the 5-Fu group were given intraperitoneal injection of 5-Fu, nude miceweight, tumor volume, tumorweight ,inhibition rate,apoptosis rate, cycle distribution of cancer cellsafter intervention were observed.
Results:
Nude miceweight, tumor volume ,tumor weight of the conventional groupwere significantly higher than those of the raltitrexed group and the 5-Fu group, the difference had statistical significance (P<0.05);The raltitrexed group'snude mice weight was higher than that of the 5-Fu group, the difference had no statistical significance (P>0.05), tumor volume, tumor weight of the raltitrexed group were lower than those of the 5-Fu group, the difference had statistical significance(P<0.05);The nude mice cancer cells S phase distribution of the conventional group was significantly higher than that of the raltitrexed group and the 5-Fu group, the difference had statistical significance(P<0.05); The S phase distribution of the raltitrexed group and the 5-Fu group had no significant difference, the difference hadno statistical significance (P>0.05);There was no significant difference between the raltitrexedgroup and the 5-Fu group in G0/G1 , the difference hadno statistical significance (P>0.05);G0/G1 phase distribution of the raltitrexed group and the 5-Fu group was lower than that of the conventional group, the difference had statistical significance (P<0.05); G2/M phrase distribution among the three groups has no obvious difference, the difference hadno statistical significance(P>0.05);The conventional group's cancer cell inhibition rate, apoptosis rate were significantly lower than those of the raltitrexed group and the 5-Fu group, the difference had statistical significance(P<0.05); While those of the raltitrexed group were significantly higher than those of the 5-Fu group, the difference had statistical significance (P<0.05).
Conclusion:
Adoptingraltitrexed for gastric cancer patients has similaranti-tumor effect with 5-Fu, which can effectively inhibit the growth of human gastric cancer cell MGC-803 xenograft tumor in nude mice and induce apoptosis of cancer cells.
2017 Vol. 23 (10): 1667-1670 [
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167
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1671
Analysis of the Efficacy and Safety of one or Two Chest| Deains after Upper Lobectomy of Lung
SHU Jian, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.025
Objective:
To compare the effect of single-tube drainage with that of two-tube drainage after upper lobectomy of lung.
Methods:
A total of 80 patients conforming to the including standard were randomly classified into a single-tube drainage group and a two-tube drainage group, consisting of 40 patients respectively. Clinical and surgical variables were collected prospectively.
Results:
There were no significant differences detected between the groups in relation to the amount of drainage or duration of drainage and other issues studied (P>0.05). But patients of single-tube drainage group had significantly lower pain scores from the second day to the fourth day after surgery, and also in two weeks(P<0.05).
Conclusion:
Single-tube drainage is as safe and effective as two-tube drainage after upper lobectomy of lung. Moreover, single-tube drainage can relieve the postoperative pain for patients.
2017 Vol. 23 (10): 1671-1673 [
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119
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1674
Study on the Efficacy and Safety of Tirofiban in Patients with Acute Myocardial| Infarction after Percutaneous Coronary Intervention
YANG Jinyong
DOI: 10.3969/j.issn.1006-6233.2017.10.026
Objective:
To investigate the efficacy and safety of tirofiban in patients with acute myocardial infarction after percutaneous coronary intervention.
Methods:
126 cases of acute myocardial infarction patients with multivessel coronary artery disease from emergency treatment in our hospital were selected, simple randomization, randomly divided into the control group and the experiment with 63 cases in each group according to the random number table method. Patients in the control group were treated with percutaneous coronary intervention; The treatment group was treated with Tirofiban Hydrochloride Injection on the basis of the control group.Two groups of patients in the postoperative unified symptomatic care.After treatment, the clinical therapeutic effect, postoperative complications, serum C reactive protein (CRP), serum creatine kinase isoenzyme (CK-MB), cardiac troponin T (cTnT) levels were compared between the two groups.
Results:
Data show that the total incidence rate of complications of the treatment group 11.11% was significantly lower than the control group 33.33% (P < 0.05); compared with before treatment, serum CRP, BNP, CK-MB and cTnT levels in patients decreased (P < 0.05), the serum CRP, BNP, CK-MB, cTnT levels were lower in experiment group than the control group (P < 0.05).
Conclusion:
The application of Tirofiban Hydrochloride Injection can effectively improve the operation effect of percutaneous coronary intervention in acute myocardial infarction patients with multivessel coronary artery disease, reduce the pain of patients, reduce the incidence of postoperative complications, control of complications have a positive effect on reducing the machine, and serum CRP, BNP, CK-MB and cTnT levels.
2017 Vol. 23 (10): 1674-1677 [
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124
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1678
Analysis of the Outcome of Skip Corpectomy for Treatment |of 4-level Cervical Spondylotic Myelopathy
YAO Guangqing, HU Yaning, TANG Ming, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.027
Objective:
To discuss the surgical outcomes of anterior skip corpectomies and fusion (ASCF) for patients with 4-level cervical spondylotic myelopathy (CSM) .
Methods:
17 cases of 4-level CSM treated with ASCF between November 2011 to November 2015 were followed up and analyzed. Used the Japanese Orthopedic Association scoring system (JOA) to demonstrate thespinal cord neurological functions. Also the cervical spine curvertures were measured with the cobb method at the same times on the lateral cervical X-ray films. The complications were recorded too.
Results:
The patients were followed up for at least 12-36 months (average 18.6 months).The mean JOA score was 8.2±0.4 (6-11) pre-operatively and 13.6±0.5 (9-17) at 12-month follow-up (P＜0.01); The cervical cobb's angle was 12.4±1.5° (-3～22°)pre-operatively and 17.5±1.6°(7～25°)at 12-month follow-up (P＜0.05); The bone graft were all fused at 12-month follow-up, and observ epseudarthrosis or segmental instability were done not.
Conclusion:
The anterior skip corpectomies and fusion (ASCF) is safe and effective in spinal cord decompression and has advantage in reconstructing and maintaining the cervical curvature for 4-level CSM.
2017 Vol. 23 (10): 1678-1680 [
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96
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1699
Effect of Short Term Intensive Insulin Therapy on Blood Glucose |in Patients with Type 2 Diabetes
RAN Kana, ZHANG Yunqing, XU Gang, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.034
Objective:
To investigate the effect of short term intensive insulin therapy on blood glucose in patients with type 2 diabetes.
Methods:
120 cases of type 2 diabetic patients were Selected from January 2015 to December 2016 in Department of Endocrinology as the object of study. Patients were divided into control and observation group by stratified randomization, 60 cases in each group. Patients in the two groups were underwent diabetic education and diet, exercise therapy; Based on the routine therapy, patients in the control group were given metformin therapy; patients in the observation group were given islet hormone intensive therapy, such as subcutaneous injection Novolin R (short acting insulin ), three times daily, 30 minutes before meals and subcutaneous injections Novolin N (acting insulin)three times daily before bedtime. Based on the glycemic control to adjust the dose of insulin, continuous treatment for 1 month. Regular follow-up 3 months, fasting insulin (fins), insulin resistance index (HOMA-IR), fasting C peptide (fc-p), postprandial 2H C-peptide (2H C-P), postprandial 2 h insulin level (Hins)were compared between the two groups to assess islet beta cell function; Besides, fasting blood glucose (FBG), 2hPG (2 h postprandial blood glucose, glycosylated hemoglobin (HbA1c) level and the adverse reactions were also compared.
Results:
After treatment, fins, fc-p, 2h C-P, 2 Hins significantly increased that compared with before treatment, and higher significant increasing at observation group, the difference were statistically significant (P<0.05). After treatment, HOMA-IR level in patients of the two group was decreased that compared with before treatment, and more lower values was observed at observation group, the difference was statistically significant (P < 0.05). Before treatment, the levels of FBG, 2Hpg and HbA1c in patients of the two groups were not significantly different; While, they were significantly decreased and more lower values observed at observation group, the difference was statistically significant. There were no obvious heart, liver and kidney function damage in patients of the two groups and without obvious adverse reactions in the control group, only 1 patient appeared low blood sugar glucose.
Conclusion:
Short term intensive insulin therapy can improve islet beta cell function in patients with type 2 diabetes mellitus, and maintain the normal range of blood glucose, which is of clinical value.
2017 Vol. 23 (10): 1699-1701 [
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153
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1702
Clinical Research of Colonoscopy Combined with Transparent Cap
JIANG Yong, ZHOU Lei, ZHANG Qunchao, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.035
Objective:
To investigate the value of colonoscopy combined with transparent cap.
Methods:
Totally 248 patients were selected from all the patients that took examinations in center of GI endoscopy between January and November in 2016. The chosen patients were divided randomly into the observation group(124 cases) and the control group(124 cases). The patients in the observation group were administrated transparent cap colonoscopy and those in the control group were administrated conventional colonoscopy. All patients were operated in non anesthetic state by one digestive endoscopic doctor. The two methods were compared by success rate, cecal intubation time, Numeric Rating Scale(NRS) and polyp detection rate. The influence factors of cecal intubation time were analyzed by gender, age, history of abdominal operation and chronic constipation.
Results:
The success rate of colonoscope of observation group and control group were 96.77% and 89.52%; cecal intubation time were (436.19±184.10)seconds and (569.57±217.15)seconds; the polyp detection rate were 42.74% and 28.23%, and the NRS were (4.06±1.84) and (5.89±2.12), respectively. There was significant difference between the two groups(P<0.05). No complication was observed in all patients. In all the influence factors of cecal intubation time, there were significant differences regarding to gender, age, history of abdominal operation and chronic constipation(P<0.05).
Conclusion:
The colonoscopy combined with transparent cap is an examination with high success rate, short cecal intubation time, high polyp detection rate and less pain of patients while gender, age, history of abdominal operation and chronic constipation are main factors that might result in longer cecal intubation time.
2017 Vol. 23 (10): 1702-1704 [
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112
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1705
The Value of Colposcopy and LEEP in Screening the |Cervical Intraepithelial Neoplasia
YU Shuli
DOI: 10.3969/j.issn.1006-6233.2017.10.036
Objective:
To explore the value of colposcopy and LEEP in screening the Cervical Intraepithelial Neoplasia.
Methods:
A total of 1810 cases were diagnosed with cervical intraepithelial neoplasia, from January 2012 to January 2014. All patients were further treated with LEEP and then processed routine pathologic examination. Cervical pathology biopsy under colposcopy, and cervical LEEP pathology were compared step by step.
Results:
The coincidence rates between Colposcopy and LEEP were CINI61.82%、CINII62.5%、CINIII73.5%.
Conclusion:
LEEP can significantly increase the diagnostic accuracy and decrease the misdiagnosis rate.
2017 Vol. 23 (10): 1705-1707 [
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115
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1708
Study on the Preventive Effects by Ephedrine combined with Methoxamine in Elderly| Patients with Gastric Cancer of Hypopiesia After General Anesthesia
WANG Yushun
DOI: 10.3969/j.issn.1006-6233.2017.10.037
Objective:
To investigate the preventive effects by ephedrine combined with methoxamine in elderly patients with gastric cancer of hypopiesia after general anesthesia.
Methods:
A total of 70 elderly patients with gastric cancer radical operation by laparoscope after general anesthesia from our hospital , the patients or their families signed an agreement, according to Simple random method was divided into the experiment group and control group with 35 cases in each group. patients in the control group were treated by conventional induction, patients in the experiment group were treated by ephedrine 6mg and methoxamine 1mg intravenous drip ,induction of general anesthesia stage, recorded the life indexes of the two groups patients before drug administration(T0) and after drug administration 5 min (T1), 15 min (T2), 30 min (T3), and recorded the adverse reactions of hypopiesia in anesthesia.
Results:
Compared with T0, the life indexes of the two groups were changed after drug administration, the systolic pressure and diastolic pressure of the experiment group were higher than the control group in T1, T2, T3 , systolic pressure and diastolic pressure and heart rate were lower than the control group, with statistical significance (P < 0.05), the blood oxygen saturation of the two groups had no changed at different time points ,had no statistical significance (P > 0.05); the hypopiesia and tachycardia incidence rate (5.71%, 8.57%) were lower than the control group (22.86%, 28.57%), the difference was statistical significance (P < 0.05), the nausea,vomiting and palpitation incidence rate of the two groups (8.57% 5.71%VS11.43% 14.29%) difference had no statistical significance (P > 0.05).
Conclusion:
Ephedrine combine with methoxamine in the treatment of elderly patients with gastric cancer after general anesthesia can provide a stable hemodynamic state, low incidence rate of hypopiesia, the effect is remarkable.
2017 Vol. 23 (10): 1708-1710 [
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116
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1711
Effects of Compound Huang Bai Liquid combined with Pevisone on the Expression |Levels of Skin Tissue K17 and Serum IL - 2, IL - 8 |in Patients with Seborrheic Dermatitis
ZHANG Jianzhen, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.038
Objective:
To investigate the effects of compound huang bai liquid combined with pevisone on the expression levels of skin tissue K17 and serum IL - 2, IL - 8 in patients with seborrheic dermatitis.
Methods:
130 patients with seborrheic dermatitis from our hospital were analyzed by retrospective study, and they were divided into experiment group and control group by random number table, 65 cases in each group. Patients in the control group were only given pevisone; While, patients in the experiment group were treated by compound huang bai liquid combined with pevisone. After treatment, the expression levels of skin tissue K17 and serum interleukin 2 (IL - 2), interleukin 8 (IL - 8) levels, the adverse reactions and the clinical efficiency in patients of the two groups patients were compared.
Results:
Compared with before treatment, the expression levels of skin tissue K17 in patients of the two groups were significantly decreased; The expression levels of serum IL - 2 and IL - 8 significantly increased (P < 0.05); Compared with the control group, the expression level of K17 in the experiment group was lower (P < 0.05), but the serum levels of IL - 2 and IL - 8 were higher (P < 0.05). The incidence rate of adverse reactions in experiment group were significantly lower than that in control group (P < 0.05). The clinical efficacy was significantly higher in experiment group than that in control group (P < 0.05).
Conclusion:
Compound huang bai liquid combine with pevisone in the treatment of patients with seborrheic dermatitis has good clinical efficacy, and could significantly reduce the incidence rate of adverse reactions. We speculate that the mechanism maybe related to the decline of the expression levels of K17 and increasing the serum IL - 2 and IL - 8 levels.
2017 Vol. 23 (10): 1711-1714 [
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1715
Curative Efficacy of Feizhen Acupuncture Combined with Ovulation |Stimulants in Treatment of Anovulatory Infertility and its effects| on Sex Hormone and Endometrium
ZHONG Weihua, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.039
Objective:
To study the curative efficacy of feizhen acupuncture combined ovulation stimulants in treatment of anovulatory infertility and its effects on sex hormone and endometrium.
Methods:
76 patients of anovulatory infertility who received therapy from September 2014 to September 2016 in our hospital were selected. According to random number table, they were divided into the observation group (n=38) and the control group (n=38). The control group was treated with oral Clomiphene, the observation group was combined with feizhen acupuncture, 2 menstrual cycles were treated continuously. The changes of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) and endometrial thickness before and after treatment were compared, and the clinical efficacy was compared.
Results:
After treatment, the FSH, LH and E2 in the two groups were significantly higher than those before treatment (P＜0.05), the FSH, LH and E2 in the observation group were significantly higher than the control group [(23.42±2.75) IU/L vs (15.78±1.93) IU/L ,(54.84±4.50) IU/L vs (29.75±2.04) IU/L, (418.34±27.56) IU/L vs (367.45±25.34) IU/L] (P＜0.05); After treatment, the endometrial thickness in the two groups increased significantly compared with that before treatment (P＜0.05); the endometrial thickness in the observation group was significantly thicker than the control group [(8.12±0.32) mm vs (7.31±0.37) mm](P＜0.05); the total effective rate of clinical efficacy in the observation group was higher than the control group [92.11% (35/38) vs 68.42% (26/38)] (P＜0.05).
Conclusion:
Feizhen acupuncture combined ovulation stimulants is well for anovulatory infertility, which can improve the expression of sex hormone, increase the thickness of endometrium and increase the rate of pregnancy.
2017 Vol. 23 (10): 1715-1717 [
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105
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1718
Clinical Analysis of Reoperation in 94 Cases of Patients with Thyroid Carcinoma
SHI Gaoyang, LU Hui, WANG Ying
DOI: 10.3969/j.issn.1006-6233.2017.10.040
Objective:
To implement clinical analysis of reoperation in 94 cases of patients with thyroid carcinoma in our hospital, and to provide a theoretical basis for the choice of mode and timing of reoperation.
Methods:
This study included 94 cases of reoperated patients with thyroid carcinoma in our hospital from June 2013 -June 2015, the medical records of 94 cases were retrospectively analyzed, and paraffin section diagnosis was taken again, the first operation mode, time of first operation to reoperation, reoperation causes and reoperation mode were recorded, through 2 years of follow up, prognosis after reoperation was observed.
Results:
There were 12 cases of reoperation at recent period (2~30d) of the first operation , the proportion was 12.77%, mid term (31d~1y) had 40 cases, the proportion was 42.55%, later period (＞1y) had 42 cases, the proportion was 44.68%; There were 78 cases showed causes of reoperation were recurrence and lymph node metastasis, the proportion was 82.98%, residual tumor after first operation had 16 cases, the proportion was 17.02%; The second pathological diagnosis showed thyroid papillary carcinoma of 80 cases, the ratio was 85.11%, 8 cases of medullary carcinoma, the ratio was 8.51%, 6 cases of follicular carcinoma, the proportion was 6.38%; Reoperation mode were 37 cases of total thyroidectomy, 33 cases of unilateral lobe and isthmus resection, 16 cases of unilateral lobe, isthmus, and contralateral subtotal resection, 4 cases of simple selective lymph node dissection, 4 cases of radical thyroidectomy and total laryngectomy; Two years of follow-up after operation, 2 cases of death due to multiple lung metastasis, 1 case of partial recurrence death due to suffocation, the rest were tumor-free survival.
Conclusion:
Partial recurrence, lymph node metastasis, residual tumor after surgery are major causes of reoperations in patients with thyroid carcinoma, pathological diagnosis are mainly thyroid papillary carcinoma, surgery mode of reoperation shall be based on color ultrasound, CT, FNAC examination.
2017 Vol. 23 (10): 1718-1721 [
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155
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1724
Clinical Observation of Tea Polyphenols and Vitaminc Intervention on |Patients with Hyperuricemia and Dyslipidemia
JIANG Shan, ZHANG Dandi
DOI: 10.3969/j.issn.1006-6233.2017.10.042
Objective:
A randomized-placebo double blind trial was performed to study the influence of tea polyphenols (TP) and vitamin C (VC) on patients with hyperuricemia and dyslipidemia.
Methods:
101 male patients with hyperuricemia with abnormal lipid metabolism were selected as the research object. All the patients were randomly divided into observation group and control group, and the observation group was given TP 300 mg/d VC 250 mg/d, the control group was given placebo. Determination and comparison of the general clinical data of intervention(Age, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure(DBP)], metabolic index metabolic index of serum uric acid (UA), total cholesterol (TC), glycerin three greases (TG), high density lipoprotein protein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), blood glucose (FBG), high sensitive C reactive protein (hs-CRP) and the antioxidant index antioxidant index (MDA), glutathione malondialdehyde (GSH), serum superoxide dismutase (SOD) changes.
Results:
Before treatment, two groups of patients with clinical data, differences between indices and antioxidant metabolism index comparison was not statistically significant (P > 0.05) ;the UA of two groups after treatment, the level of FBG decreased significantly after treatment, and patients in the control group LDL-C level was significantly decreased, the difference was statistically significant (P<0.05). Between the two groups, the control group of patients with UA, TC, hs-CRP index level difference was statistically significant with P<0.05). Two groups of patients with MDA index decreased significantly, the difference was statistically significant (P<0.05.SOD). GSH index was significantly higher than that before treatment, the difference was statistically significant (P<0.05). Comparison between groups, serum MDA level of observation group compared with the control group decreased significantly (P<0.05); serum SOD and GSH levels had no statistical comparison significance (P > 0.05).
Conclusion:
In patients with hyperuricemia and dyslipidemia, the combined supplementation of tea polyphenols and vitamin C can significantly reduce serum uric acid and blood lipid levels. And it can improve the body antioxidant index, is a reliable means of intervention prevention and treatment of hyperuricemia.
2017 Vol. 23 (10): 1724-1728 [
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182
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1729
The Analysis of Hedgehog Fungus Extract Granules in the Treatment for |Spleen Deficiency Syndrome after Infection in 106 Children
LI Xue, ZHAO Min, GENG Wenjing, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.043
Objective:
To study the clinical efficacy of hedgehog fungus extract granules in the treatment for spleen deficiency syndrome after infection in children.
Methods:
The 106 children patients with spleen deficiency syndrome after infection in our hospital during the period from Jan 2016 to Dec 2016 were randomized into the control group (treatment of live combined Bifidobacterium and Lactobacillus tablets, 48 patients) and the observation group (addition to control group, treatment of hedgehog fungus extract granules, 58 patients) according to the random number method. The total clinical efficacy, the changes of humoral immunity and cellular immunity pre- and post-treatment in two groups were compared.
Results:
Compared with the control group, the total effective rate of treatment was significantly increased in the observation group with statistical difference (96.6% vs 70.8%, P<0.05); compared with the control group, the humoral immune function was obviously improved and the levels of IgG and IgA on post-treatment were significantly increased in the observation group with statistical difference (P<0.05); compared with the control group, the cellular immune function was obviously improved and the levels of CD3, CD4, CD4/CD8 on post-treatment were significantly increased in the observation group with statistical difference (P<0.05).
Conclusion:
The treatment of hedgehog fungus extract granules can significantly improve the immune function for spleen deficiency syndrome after infection in children and increase the clinical efficacy of treatment.
2017 Vol. 23 (10): 1729-1731 [
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185
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1732
Curative Efficacy and Safety Evaluation of Small Dose of Low-molecular-weight| Heparin Calcium for the Treatment of Children with Sepsis
HUANG Jiexing, WANG Jinhua, WANG Dengfeng, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.044
Objective:
To evaluate the curative efficacy and safety of small dose of low-molecular-weight heparin calcium for the treatment of children with sepsis.
Methods:
92 cases of children with sepsis were randomly divided into control group(46 cases) and experiment group(46 cases). Patients in both groups were given oxygen, anti-infection, treatment of the original disease and other conventional treatment. According to the control group, patients in the experiment group were given low molecular weight heparin calcium at 10 IU/kg every 12 hours by subcutaneous injection. After treatment, coagulation function and clinical curative effect were compared.
Results:
The total clinical efficacy of the treatment group (95.65%) was significantly higher than that of the control group (69.57%), the difference was statistically significant (P<0.05). After treatment, the PT, TT and APTT in 2 groups were slightly decreased, but not statistically different (P<0.05). The APTT, PT and TT in patients of the treatment group were significantly lower than that in the control group (P<0.05). The FIB levels were significantly increased with time and the values in experiment group were significantly higher than that in control group (P<0.05). There was no significant difference in adverse reactions between the two groups (P > 0.05).
Conclusion:
Small dose of low molecular weight heparin calcium can improve the clinical treatment efficacy, improve the coagulation function in children with sepsis.
2017 Vol. 23 (10): 1732-1734 [
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143
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1744
Study on the Demands for “Internet Plus” Home-Based |Medical-Nursing Combined Service for the Elderly
DU Shaoying, WANG Yan, ZHOU Yi, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.048
Objective:
The paper studies the demands for the “internet plus” home-based medical-nursing combined services for the elderly.
Methods:
By convenience sampling,a total of 63 elders were enrolled on the questionnaire survey.
Results:
Among the 63 elders,the demand rate for “internet plus” home-based medical-nursing combined service was 74. 89% . The demand for medical service is the highest, such as emergency rescue (100%), physical examination(98.4%)and medical rehabilitation(98.4%). Whereas the demand for household service is the lowest.
Conclusion:
The demand rate for “internet plus” home-based medical-nursing combined service among elders is high. Practitioners should meet the needs of its medical services, daily care, spiritual consolation, rights protection and health benefits.
2017 Vol. 23 (10): 1744-1746 [
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135
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1747
Study on the Application of PDCA Circulation Management Mode in Continuous| Improvement of Nursing Quality in Combination of Medicine and Nursing
GU Jianli, WANG Juan, WANG Yaoman
DOI: 10.3969/j.issn.1006-6233.2017.10.049
Objective:
To investigate the application of PDCA circulation management mode in continuous improvement of nursing quality in combination of medicine and nursing.
Methods:
172 cases of elderly patients who were admitted to the hospital in the "medical" or "foster" state were selected and randomly divided into the control group and the experiment group with 86 cases in each group. After admission, the patients in the control group were given the mode of combining medical care with old-age care, and routine safety nursing methods were adopted; the experimental group received the nursing service after the PDCA circulation management mode on the basis of the control group. The service attitude, professional level, ward management, health education, nursing quality, satisfaction degree, assessment and safety incident were compared between the two groups.
Results:
After the intervention, two groups of nursing evaluation scores were significantly higher (P < 0.05); the experimental group of PDCA cycle management service attitude, service level, ward management and health education nursing evaluation was significantly better than the control group (P < 0.05); compared with the control group, the experimental group "critically ill patients, nursing ward management, nursing safety," the high degree of recognition; and hospital service satisfaction index was significantly higher (P < 0.05). At the same time, the test group security incident rate is low (P < 0.05).
Conclusion:
Applying PDCA circulation management mode to carry out high quality nursing can provide the high quality, safety and satisfactory nursing service for patients with medical and nursing support. It can continuously improve satisfaction and clinical nursing quality for patients.
2017 Vol. 23 (10): 1747-1750 [
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152
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1751
The Preliminary Construction of Evaluation Indicators for Diabetic Nurse Training
WANG Lining, WANG Chunhua, SUN Liming, et al
DOI: 10.3969/j.issn.1006-6233.2017.10.050
Objective:
To construct the evaluation system of the training effect of nurses in diabetes mellitus, and to determine the weight of indicators at all levels.
Methods:
Using the Delphi method to Koch's model theory as a guide, using the analytic hierarchy process to determine the weight of the primary indicators, using the weight method to determine the weight of two, three indicators.
Results:
The weights of the first-level indicators are: reaction layer 0.116, learning layer 0.156, behavior layer 0.400, result layer 0.326, and the primary index weight of the logical consistency test CR are less than 0.1. (0.084), the radiation effect (0.081), the theoretical knowledge (0.078), the skill operation (0.076), the higher the weight of the secondary index.
Conclusion:
Based on the Kocher model, the weight and significance of the evaluation system of the training effect of the nurses in diabetes mellitus have certain scientificity, which can provide reference for the training effect of diabetes mellitus nurses.
2017 Vol. 23 (10): 1751-1756 [
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162
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