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2017 Vol. 23, No. 6
Published: 2017-06-20
882
Comparison of the Effects of PDD and PTD and IL-6 Levels in Patients with Multiple Myeloma
XIE Wei, PANG Ying, YE Xu, et al
DOI: 10.3969/j.issn.1006-6233.2017.06.02
Objective:
To study the contrast PDD (Bortezomib + liposome adriamycin + dexamethasone) with PTD (Bortezomib + pirarubicin + dexamethasone) solutions in patients with multiple myeloma curative effect and the influence of the level of IL - 6.
Methods:
From January 2012 to January 2017, Selection of 38 cases of patients with MM.According to the different methods of treatment were divided into PDD group (19 cases), PTD group 19 cases.4 weeks after treatment, respectively observed before and after treatment of the two groups of clinical curative effect, before and after treatment serum levels of IL - 6,M protein,tumor cells and β
2
-microglobulin and adverse reactions occured.
Results:
The PDD treatment group total remissio rate(sCR+CR) was 31.58% (6/19), compared with PTD group 5.26% (2/19), there's significant difference (P < 0.05).In the two groups after treatment than before treatment, serum levels of IL - 6 and PDD and below the PTD group, and had significant difference (P < 0.05).M protein PDD group after treatment, the tumor cells and β
2
-microglobulin levels were below the PTD group, and had significant difference (P < 0.05).PDD and PTD group the incidence of hematologic adverse reactions with no significant difference (P > 0.05),but the incidence of alopecia and cardiac toxicity in PDD group was significantly lower than PTD group.
Conclusion:
The PDD therapy in the treatment of MM had better clinical curative effect, and can effectively improve the patients' serum level of IL - 6,M protein,tumor cells and β
2
-microglobulin, better security, worthy of clinical popularization and application.
2017 Vol. 23 (6): 882-885 [
Abstract
] (
268
)
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886
Effect of Brinzolamide on Primary Open-angle Glaucoma and Vision Protection
QIU Manchun, YAN Wenjing, YANG Xuelian, et al
DOI: 10.3969/j.issn.1006-6233.2017.06.03
Objective:
To investigate the clinical effects of brinzolamide treatment of primary open-angle glaucoma and its effect on the patient's field of vision protection.
Methods:
98 cases of primary open-angle glaucoma patients were randomly divided into control group and observation group, 49 cases in each group. Patients in the control group were treated with conventional symptomatic treatment .Patients in the observation group rnderwent treatment of brinzolamide based on the control group.
Results:
After treatment, MD in the observation group patients compared with before treatment were decreased, the difference was statistically significant (P <0.05). After treatment, MD and average visual field defects variance in the observation group patients were lower than the control group, while MS in the observation group patients were higher than the control group, the difference was statistically significant (P <0.05).
Conclusion:
Brinzolamide treatment of primary open-angle glaucoma can effectively protect patient vision, control visual field defect and reduce the variance of visual field defect, improve patient quality of life.
2017 Vol. 23 (6): 886-888 [
Abstract
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117
)
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889
Effect of Transfection of ELF5 mRNA on Apoptosis and Cycle of Endometrial Carcinoma Cells
QI Ting, et al
DOI: 10.3969/j.issn.1006-6233.2017.06.04
Objective:
To study the effects of ELF5 gene on cycles and apoptosis of human endometria cancer cells and its probable mechanism.
Methods:
The eukaryotic expression vectedical or pcDNA3.1-ELF5+EGFP was transfected into human endometria cancer cells in vitro (recombinant plasmid group), and positive cell clones were selected by G418 and amplified. Transfected pcDNA3.1-EGFP cells (empty plasmid group) and untransfected cells (blank control group) were served as control groups. In vitro, the cell prolifetraion ability of three groups was analyzed by MTT; the cycle and apoptosis was analyzed by flow cytometry; the expression of protein P21 and Caspase-3 was detected by Western blot. In vivo, three groups of cells were transplanted into NOD/SCID nude mice, and observed the growth ability of tumors; the apoptosis of tumors was determined by TUNEL; the expression of protein P21 and Caspase-3 in tumors was detected by Western blot.
Results:
The recombinant plasmid pcDNA3.1- ELF5+EGFP was successfully transfected into human endometria cancer cells; The expression of ELF5 mRNA in the recombinant plasmid group was higher than that in the empty plasmid group and blank control group (P<0.05); At each time point, the cell proliferation ability of the recombinant plasmid group was significantly decreased than that of the empty plasmid group and blank control group, the differences were statistically significant (P<0.05); The number of cells arrested in G
0
/G
1
phase of the recombinant plasmid group was higher than that of the empty plasmid group and blank control group, the differences were statistically significant (P<0.05); The apoptosis rate of the recombinant plasmid group was compared with the empty plasmid group and the blank control group, the differences were statistically significant (P<0.05); The expression of protein P21 and Caspase-3 in the recombinant plasmid group was higher than that in the empty plasmid group and blank control group (P<0.05). In vivo, the growth ability of tumors (maximum diameter, weight) in recombinant plasmid group was lower than that in the empty plasmid group and blank control group, the differences were statistically significant (P<0.05); In vivo, the apoptosis rate of the recombinant plasmid group was compared with the empty plasmid group and the blank control group, the differences were statistically significant (P<0.05); In vivo, the expression of protein P21 and Caspase-3 in the recombinant plasmid group was higher than that in the empty plasmid group and blank control group (P<0.05).
Conclusions:
ELF5 gene has obvious effects on cycles and apoptosis of human endometria cancer cells and its mechanism connected with the protein P21 and Caspase-3.
2017 Vol. 23 (6): 889-894 [
Abstract
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141
)
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895
Comparative Study of the Efficacy of Limitesd Fluid Resuscitation and Conventional Fluid Resuscitation in Uncontrolled Hemorrhagic Shock
WANG Bin, WANG Xinyi
DOI: 10.3969/j.issn.1006-6233.2017.06.05
Objective:
To explore and analyze limitesd fluid resuscitation and conventional liquid recovery efficacy for the treatment of uncontrolled hemorrhagic shock.
Methods:
90 cases of patients with uncontrolled hemorrhagic shock admitted in our hospital from April 2015 to April 2017 were selected as objects. All the patients were divided into limitesdgroup and conventional resuscitation group by random number table, 45 cases in each group. The mortality and complication rates and laboratory indexes, average infusion quantity of two groups were compared.
Results:
Compared with the conventional liquid resuscitation group, the 24h mortality rate, the mortality rate and complication rate in the 1 weeks were lower and the average transfusion rate was less, and the difference was statistically significant (P<0.05). After two groups of treatment, compared with before treatment, HBG, Hct, PLT, BUN and Scr levels increased, PT time shortened, compared with the routine fluid resuscitation group, the indexes of the liquid resuscitation group improved more significantly. The difference was statistically significant (P<0.05).
Conclusion:
Compared with conventional fluid resuscitation, the treatment of hemorrhagic shock with limited fluid resuscitation has significant efficacy, low mortality and complication rate, better improvement of laboratory indexes and promotion of prognosis.
2017 Vol. 23 (6): 895-897 [
Abstract
] (
139
)
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898
Application of Immunofluorescence and other Special Staining in Pathological Diagnosis of Renal Biopsy
LUO Jiaoxiu, CHU Bing, CAO Xiaoshan, et al
DOI: 10.3969/j.issn.1006-6233.2017.06.06
Objective:
To analyze the effect of immunofluorescence and other special staining methods in the pathological diagnosis of renal biopsy.
Methods:
58 patients with chronic kidney disease admitted in our hospital from September 2014 to September 2016 were included in the object of study. All patients underwent renal biopsy puncture to obtain tissue using paraffin, respectively by immunofluorescence, six staining of methanol method, Congo red staining and mucin (PAS) and three Masson dye staining, staining results in different ways.
Results:
The positive rates of IgA, IgM, IgG, C3 and Clq in the patients with different types of nephropathy were significantly higher than those of IgA nephropathy and membranous nephropathy in patients by immunofluorescence staining. In the comparison of different staining methods, it was found that the positive rate of IgA, IgM, IgG, C3 and Clq detected by immunofluorescence staining was significantly lower than that of other staining methods, P<0.05. There was no difference in the diagnostic rate of other staining methods, P>0.05.
Conclusion:
Comparing with other methods, the rate of pathological diagnosis of renal biopsy is lower than that of other methods. It is recommended to use other special staining methods to diagnose renal tissue.
2017 Vol. 23 (6): 898-901 [
Abstract
] (
348
)
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902
High Dose Atorvastatin on Coronary Artery Stenosis and hs-CRP in Patients with Unstable Angina Pectoris
LU Qingyu, CHANG Yufeng, LIU Geng
DOI: 10.3969/j.issn.1006-6233.2017.06.07
Objective:
To explore the influence of high-dose atorvastatin on the degree of coronary artery stenosis, hs-CRP for unstable angina (UA) patients.
Methods:
145 cases of UA patients admitted in our hospital from July 2013 to July 2015 were choosen as the research object, and those patients were randomly divided into two groups by the random number table method: the control group and study group. Both groups were given aspirin, metoprolol, and isosorbide dinitrate tablets as the conventional treatment. In the meantime, the control group (70 cases) was given Atorvastatin 10mg per day; while the study group (75 cases) was given atorvastatin 40mg per day. Before and after treatment of 7d, 15d, 30d treatment, high sensitivity C reactive protein in the patients of the two groups (hs-CRP) and a-lipoprotein level were recorded. And the pearson correlation analysis on the relationship between hs-CRP and the degree of coronary artery stenosis were analyzed.
Results:
The hs-CRP level of the study group were all significantly lower than that of the control group after 7-day and 15-day's treatment (P<0.05); the vascular embolization rate of the study group was significantly lower than that of the control group after 15-day and 30-day's treatment (P<0.05). And Pearson correlation analysis revealed that the serum hs-CRP were all significantly associated with the degree of coronary artery stenosis (r=0.264, P=0.032; r=0.425, P=0.014).
Conclusion:
Early large-dose application of atorvastatin can significantly reduce the level of hs-CRP and vascular embolization rate for UA patients, and the level of hs-CRP are positively correlated with the degree of coronary artery stenosis.
2017 Vol. 23 (6): 902-904 [
Abstract
] (
142
)
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905
Effect of Shenqifuzheng Injection on Chinese Medicine Syndrome in Patients with Lung Cancer Undergoing Radiotherapy
ZHANG Zhenjun, YANG Xinyan, BAI Lu, et al
DOI: 10.3969/j.issn.1006-6233.2017.06.08
Objective:
To investigate the effects of Shenqifuzheng injection on Chinese medicine syndrome in patients with three-dimensional conformal radiotherapy of lung cancer.
Methods:
90 cases of lung cancer patients randomly divided into treatment group (Shenqifuzheng group), positive control group (Addie injection group) and blank control group and all the patients' data were analyzed.
Results:
The end of treatment, three groups of patients after treatment of TCM syndrome points were lower than those before treatment. The TCM syndrome points in Shenqi group before and after treatment were more significant differences (P<0.01); Shenmai group before and after treatment the difference was statistically significant (P <0.05 ); placebo group before and after treatment showed no significant difference (P>0.05). The Shenqi group compared with others before and after treatment was significant differences (P<0.05 or P<0.01). However, the data of spontaneous sweating and dizziness had no statistically significant.
Conclusion:
Shenqifuzheng injection fluid from the main function of the vital essence, Qi and spleen, and its effect in the treatment of lung weakness significantly better than Addie injection, can be used as a chemotherapeutic adjuvant.
2017 Vol. 23 (6): 905-907 [
Abstract
] (
156
)
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908
Liver and Blood Lipid Changes after Antipsychotic Treatment for Schizophrenia
CHEN Fang, PENG Shoulin, ZHOU Rong
DOI: 10.3969/j.issn.1006-6233.2017.06.09
Objective:
To evaluate the efficacy of four kinds of antipsychotic treatment of schizophrenia and the treatment of liver and blood lipid changes.
Method:
160 patients with schizophrenia who were enrolled from January 2015 to February 2016 were randomly divided into four groups: risperidone, quetiapine, olanzapine and aripiprazole group, respectively. Treatment efficiency, PANSS score before and after treatment, blood lipid levels, fatty liver and adverse drug reactions.
Result:
There was no significant difference between the four groups in the overall treatment rate and the overall incidence of fatty liver, and there was no statistical significance (P>0.05); After olanzapine treatment, the total score of PANSS group was significantly lower than that of quetiapine group; The levels of TC, TG and LDL in the quetiapine group were significantly higher than those in the other three groups, and the levels of TG and LDL in the olanzapine group were significantly lower than those in the risperidone group and the aripiprazole group; The incidence of other adverse reactions in quetiapine group was significantly higher than that of the other three groups, there was significant difference (P<0.01).
Conclusion:
Four kinds of dugs can be effective antipsychotics in the treatment of schizophrenia, but quetiapine on blood lipid influence, adverse reaction rate is the highest, while the relative efficacy of olanzapine on lipid stability, small adverse reaction rate is the lowest, so it can be recommended as the primary drug.
2017 Vol. 23 (6): 908-910 [
Abstract
] (
123
)
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911
Myocardial Troponin I in Myocardial Damage Monitoring in Patients with Thoracic Tumor
HUANG Tian
DOI: 10.3969/j.issn.1006-6233.2017.06.010
Objective:
To investigate the effect of cardiac troponin I (cTnI) on myocardial injury in patients with thoracic tumor.
Methods:
During the period of 2012-2016 in our hospital, specific cTnI and creatine kinase during radiotherapy (CK-MB) monitoring results of 43 cases of patients with chest tumor (observation group) and 28 cases of non breast cancer (control group) in different time were compared; the abnormal situation of cTnI, CK-MB of two groups were analyzed; the clinical value of cTnI for monitoring the myocardial injury in patients with thoracic tumor was studied.
Results:
In the observation group, in addition to cTnI CK-MB before radiotherapy, DT=50Gy had no statistical difference (P>0.05); the difference between two groups were statistically significant (P<0.05); the results of DT=50Gy, DT=60-70Gy and cTnI after radiotherapy abnormal rate between the two groups by chi square test were statistically significant (P<0.05); the results of DT=60-70Gy and radiotherapy and the abnormal rate of CK-MB by chi square test were statistically significant (P<0.05). cTnI and CK-MB of the control group in the process of radiotherapy didn't appear abnormal. In the observation group, the abnormal rate of DT=60-70Gy was higher than that of CK-MB, but the difference of cTnI was statistically significant (P<0.05).
Conclusion:
cTnI of radiotherapy in patients with thoracic cancer early cardiac injury monitoring effect, symptomatic treatment necessary for patients with early cardiac injury of chest tumor timely adjust the irradiation scheme, to improve the quality of life of cancer patients has important clinical significance.
2017 Vol. 23 (6): 911-914 [
Abstract
] (
123
)
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915
Bronchoalveolar Lavage in the Treatment of Elderly Patients with Severe Pulmonary Infection with Atelectasis
XU Youdong, et al
DOI: 10.3969/j.issn.1006-6233.2017.06.011
Objective:
To observe the clinical effect of lung lavage by bronchofibroscope in the treatment of elderly severe pulmonary infection patients with atelectasis and explore the effective treatment measures.
Method:
70 cases elderly severe pulmonary infection patients at the same time were selected and divided into control group and observation group. The control group was treated with conventional anti-inflammatory therapy and adjuvant therapy. The observation group was added with lung lavage by bronchofibroscope. Compared with the changes of blood gas index after one week's treatment, the clinical symptoms and related treatment experience time, the clinical curative effect and the sequelae after four weeks of discharge.
Results:
After one week treatment the blood gas index of observation group were significantly better than those of control group (P<0.05). The time of clinical symptoms disappearance and related treatment were significantly shorter than that of the control group (P<0.05). The satisfaction rate of clinical treatment was significantly higher than that of the control group (P< 0.05). The number of sequelae after discharge four weeks was significantly less than that of the control group (P<0.05).
Conclusion:
In treating elderly severe pulmonary infection patients with atelectasis, it should be actively added treatment of lung lavage by bronchofibroscope. And it could improve the clinical efficacy, promote the recovery of patients and reduce the sequelae after treatment.
2017 Vol. 23 (6): 915-917 [
Abstract
] (
135
)
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174
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918
GnRH-a on Endometriosis and the Level of Histone H3K4 Methylation in Patients with Endometriosis
JIN Fengyu
DOI: 10.3969/j.issn.1006-6233.2017.06.012
Objective:
To investigate the efficacy of gonadotropin releasing hormone agonist (GnRH-a) in the treatment of endometriosis (EMS) and the effect on the level of histone 3 lysine 4 (H3K4) methylation in patients with endometriosis.
Method:
96 cases of EMS patients admitted in our hospital from January 2015 to June 2016 were selected as the study subjects. All patients were treated with elective laparoscopic surgery and were randomly divided into the observation group and the control group, 48 cases in each group. The control group was treated with mifepristone after surgery, and the observation group was additionally treated with GnRH-1. The effective rate of treatment, pregnancy rate, recurrence rate, levels of follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E
2
) were compared between the two groups. The positive rate of anti-endometrial antibody (EMAB), positive rate of angiopoietin-2 (Ang-2), H3K4 methylation, tissue inhibitor of metalloproteinase-1(TIMP-1), vascular endothelial growth factor (VEGF) and glycoprotein 125 (CA125) in the two groups were analyzed, and adverse reactions were observed.
Results:
The total effective rate of treatment and the pregnancy ratein the observation group were significantly higher than those in the control group (97.92% and 29.17% vs 85.42% and 10.42%) (P< 0.05), and the half-year recurrence rate was lower than that in the control group (2.08% vs 16.67%) (P< 0.05). After treatment, levels of serum FSH, LH and E
2
were significantly lower in the observation group than the control group (P< 0.05). After treatment, the positive rates of EMAB and Ang-2 in the observation group were lower than those in the control group, while H3K4 methylationwas higher than that in the control group (P< 0.05). After treatment, the levels of serum TIMP-1, VEGF and CA125 were significantly lower in the observation group than the control group (P< 0.05). There was no significant difference between the two groups in the incidence of adverse reactions (10.42% vs 6.25%) (P > 0.05).
Conclusion:
GnRH-a is better than mifepristone in the treatment of EMS. It can significantly reduce the levels of hormone, EMAB, Ang-2, serum TIMP-1, VEGF and CA125 level and the recurrence rate. It also can improve the H3K4 methylation level and pregnancy rate, with high safety.
2017 Vol. 23 (6): 918-922 [
Abstract
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137
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923
Efficacy and Safety Analysis of Gaba Martin Add treatment in the Treatment of Refractory Partial Epilepsy Patients
SHAO Guangtian, et al
DOI: 10.3969/j.issn.1006-6233.2017.06.013
Objective:
To investigate the efficacy and safety analysis of Gaba Martin Add treatment in the treatment of Refractory partial epilepsy patients.
Method:
70 Refractory partial epilepsy patients admitted to neurology department of our hospital were selected and randomly divided into the control group and the experiment group with 35 cases in each group. The control group was given a Carbamazepine Tablets starting dose of 5mg/kg daily, gradually increased to 20 mg/kg. Topiramate Tablets starting dose of 0.8mg/kg per day could be gradually increased to 7mg/kg. The patients in the experimental group were added gabapentin Capsule on the basis of the control group. First gabapentin capsules 300mg orally every time, 1 times a day, second doses of gabapentin capsules 300mg orally every day, 2 times a day, third days until the end of treatment for gabapentin capsules 300mg oral every time, 3 times a day. Two groups of patients were treated for a period of 6 months. After treatment, the clinical efficacy, memory function, the degree of neurological deficit, T lymphocyte group, serum immunoglobulin and adverse reactions were compared between the two groups.
Results:
After treatment, 2 weeks after the onset of the attack frequency and the frequency of attack after 12 weeks was lower than the baseline frequency. Compared with before treatment, after treatment, the 2 groups of CMS score increased, NFDS score decreased, IgA, IgG and IgM levels decreased, serum CD
3+
, CD
4+
, CD
4+
/ CD
8+
increased(P＜0.05). Compared with the control group, the total effective rate of treatment group was higher after 4 weeks, 12 weeks after the onset of lower frequency, higher CMS scores, lower NFDS score, IgA, IgG and IgM low level of serum CD
3+
, CD
4+
, CD
4+
/, CD
8+
high and low incidence rate of adverse reaction, the difference has statistical significance(P＜0.05). There was no significant difference between the 2 groups before and after treatment with CD
8+
(P＞0.05).
Conclusion:
The clinical efficacy of gabapentin in the treatment of refractory partial epilepsy is significant. It can improve the memory function, nerve function and immune function of patients.
2017 Vol. 23 (6): 923-926 [
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132
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927
Comparative Study of TEP and Lichtenstein in the Repair of Hernia
SHEN Yawei, HUANG Xin, MA Xiaoan, et al
DOI: 10.3969/j.issn.1006-6233.2017.06.014
Objective:
To compare the clinical application of TEP and Lichtenstein in hernia repair.
Methods:
A total of 106 patients with TEP were treated with PEP from March 2013 to February 2015, and 104 patients with inguinal hernia treated with Lichtenstein were selected as the subjects. The patients in the two groups were enrolled in this study. The operation time, postoperative pain score, intraoperative blood loss, postoperative bed time, average hospital stay, hospitalization costs and postoperative complications of two groups were retrospectively analyzed.
Results:
The two groups of patients with smooth operation, no serious intraoperative and postoperative complications (P<0.05). The cost of operation was significantly higher than that of Lichtenstein group (P <0.05). The operation time of TEP group was significantly lower than that of Lichtenstein group (P<0.05). The difference was not statistically significant (P> 0.05). The levels of foreign body sensation, urine retention, scrotal serema, early postoperative pain score and long-term chronic neuropathic pain were observed in the TEP group after 5 days of operation and 6 months of follow-up. Retrospective analysis of two groups of patients after 5 days and 6 months of follow-up, the TEP group in postoperative foreign body sensation, urinary retention, scrotal seroma, early postoperative pain score, postoperative long-term chronic neuropathic pain incidence were lower than group Lichtenstein (P<0.05).
Conclusion:
TEP has the advantages of minimally invasive surgery, rapid recovery of patients after surgery, less pain, less complications, worthy of promotion and application.
2017 Vol. 23 (6): 927-930 [
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115
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931
Analysis of Related Risk Factors of Type 2 Diabetes Mellitus Complicated with Pulmonary Tuberculosis
SU Xiaohui, KONG Zheng, WANG Man
DOI: 10.3969/j.issn.1006-6233.2017.06.015
Objective:
To analyze the related risk factors of type Ⅱ diabetes mellitus (T2DM) complicated with pulmonary tuberculosis.
Method:
135 cases of T2DM complicated with pulmonary tuberculosis patients admitted in our hospital from January 2009 to January 2014 were selected as the observation group (n=135), and the other 138 cases of patients with T2DM during the same period as the control group (n=138). The clinical data of patients of two groups were retrospectively analyzed.
Results:
By Logistic regression analysis, diabetes, exercise, living conditions, diet, medication, specification of pulmonary tuberculosis contact history, blood glucose monitoring and control, impaired renal function, impaired liver function and lipid metabolism disorder was related to risk of type II diabetes complicated with pulmonary tuberculosis factors.
Conclusion:
The longer the duration of diabetes, less outdoor sports, the medication is not standardized, poor living and diet, have tuberculosis contact history, impaired renal function, impaired liver function and lipid metabolism disorders that type II diabetes patients complicated with pulmonary tuberculosis easily; to improve the prognosis of patients, suggest systematic health education on the patients with type II diabetes mellitus pulmonary tuberculosis.
2017 Vol. 23 (6): 931-934 [
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] (
136
)
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935
Analysis of the Efficacy of Combination of Ticagrelore and Rosuvastatin in the Treatment of Unstable Angina Pectoris
FU Mingming, LU Jian
DOI: 10.3969/j.issn.1006-6233.2017.06.016
Objective:
To study the clinical curative effect of ticagrelor combined with rosuvastatin in treatment of unstable angina.
Methods:
186 patients with unstable angina were randomly divided into control and observation group. The patients in the control group were treatment with Clopidogrel Hydrogen Sulphate and Rosuvastatin Calcium. The patients in the observation group were treatment with Ticagrelor and Rosuvastatin Calcium. The lipid levels and clinical efficacy between the two groups were observed. Results After treatment, the levels of TC, TG,LDL-C in the observation group were lower than those in the control group, while the level of HDL-C higher than that in the control group, the difference was significant (P<0.01).The total effective rate was 89.2% in the observation group and 68.9% in the control group with significant difference (P<0.01). The incidence of adverse reactions in two groups had no significant difference (P>0.05).
Conclusion:
Ticagrelor combined with rosuvastatin has significant clinical effect in treatment of unstable angina.
2017 Vol. 23 (6): 935-936 [
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160
)
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937
Comparison of Laparoscopic common Bile Duct Exploration and Endoscopic Duodenal Sphincterotomy in the Treatment of Common Bile Duct Stones
LI Jun
DOI: 10.3969/j.issn.1006-6233.2017.06.017
Objective:
To investigate the efficacy of laparoscopic common bile duct exploration and endoscopic duodenal sphincterotomy in the treatment of common bile duct stones.
Methods:
200 patients with choledocholithiasis who were enrolled from January 2016 to September 2016 were randomly divided into two groups. Laparoscopic patients underwent laparoscopic common bile duct exploration. Endoscopic group Intra-papillary sphincterotomy, compared the two groups of patients with perioperative clinical indicators, postoperative monitoring indicators, perioperative and long-term complications.
Results:
The length of the patients in the laparoscopic group, the amount of blood loss during operation, the time of operation, the recovery time of gastrointestinal function, the time of hospitalization, acute pancreatitis, the incidence of total perioperative complications, recurrence of stone recurrence and overall long-term complication (P <0.05) .There was significant difference between the two groups (P <0.05) .
Conclusion:
The efficacy of laparoscopic common bile duct exploration in the treatment of common bile duct stones is more significant, lower trauma, higher safety, with reference.
2017 Vol. 23 (6): 937-940 [
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151
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941
Effects of Simvastatin on OFR, NO and NOS in Brain Tissue of Rats with Renal Ischemia Reperfusion Injury
JING Jiao, ZHANG Yongzhong, YAN Wensheng, et al
DOI: 10.3969/j.issn.1006-6233.2017.06.018
Objective:
To observe the effect of simvastatin on brain tissue after renal ischemia reperfusion injury and its mechanism.
Methods:
A rat model of renal ischemia reperfusion injury (RIRI) was prepared by clamping the bilateral renal arteries for 45 minutes(10% chloral hydrate intraperitoneal anesthesia, open the abdominal cavity, exposed bilateral renal artery and vein, clamping the bilateral renal artery and vein with artery clamp, 45min after removal of the artery clamp to restore blood flow, and then suture the abdominal wall). 36 rats were randomly divided into the following groups, 12 rats in each group: sham operation group; renal ischemia reperfusion group; simvastatin group. Detection of serum creatinine (Scr), urea nitrogen (BUN), brain tissue malondialdehyde (MDA) and nitric oxide (NO) content, superoxide dismutase (SOD) and inducible nitric oxide synthase (iNOS) activity in brain tissue was detected in endothelial nitric oxide synthase (eNOS) protein expression level.
Results:
Compared with the sham operation group, the contents of Scr, BUN, MDA, NO and iNOS activity in the ischemic group increased (P<0.05), while the activity of SOD decreased (P<0.05). Compared with the ischemia reperfusion group, the content of SCr, BUN and MDA decreased, iNOS activity was decreased (P<0.05), but the activity of SOD and the content of NO increased (P<0.05). The content of eNOS protein in renal ischemia reperfusion group was higher than that in sham operation group (P<0.05), and the content of eNOS protein in simvastatin group was higher than that in the renal ischemia reperfusion injury group (P<0.05).
Conclusion:
Simvastatin can protect the brain from ischemia reperfusion injury. It may be related to decreased the activity of iNOS, and increase the expression of eNOS protein and the content of NO.
2017 Vol. 23 (6): 941-943 [
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82
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944
Clinical Value of Vacuum Sealing Drainage in the Treatment of Diabetic Foot Ulcer with Different Severity
WU Miaoqiong, LIU Yanhong, LUO Qunfang, et al
DOI: 10.3969/j.issn.1006-6233.2017.06.019
Objective:
To investigate the clinical value of vacuum sealing drainage (VSD) in different severity of diabetic foot ulcer (DFU) by randomized controlled study.
Methods:
40 cases of patients selected Wagner 2~4 grade of DFU were randomly divided into treatment group and control group, each of 20 cases. The treatment group was treated with VSD after debridement; the control group created by the method of wet dressing; 4 weeks of observation, to compare the two methods of different severity of DFU clinical effect.
Results:
The number of days in hospital, the number of dressing changes and the number of times of dressing change and cure time were significantly shorter in the observation group than in the control group, the difference was statistically significant (P < 0.05). The total effective rate of the observation group was 100.0%, which was significantly higher than that of the control group of 80.0%, the difference was statistically significant (P < 0.05).
Conclusion:
DFU using (VSD) basically to avoid major amputation and achieve guaranteed toe salvage and to retain the ability of action; VSD surgery treatment at all different severity of DFU effect is significant, hospitalization time and frequency of changing dressings reduce, and the total cost of health care has no advantage.
2017 Vol. 23 (6): 944-947 [
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100
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948
Clinical Effect of Sufentanil Combined with Ropivacaine on Postoperative Prolactin in Parturients Undergoing Cesarean Section
LIN Yali, DING Yi, QIN Miao
DOI: 10.3969/j.issn.1006-6233.2017.06.020
Objective:
To investigate the application of sufentanil and ropivacaine in postoperative analgesia for cesarean section and neonatal conditions.
Methods:
200 cases of cesarean section delivery of singletons full-term birth admitted nearly 1 year in our hospital were randomly divided into two groups, respectively selected sufentanil combined with ropivacaine, epidural analgesia and pethidine intermittent intramuscular injection were used to relieve pain.
Results:
The visual analogue pain score of VAS in the observation group was significantly lower than that in the control group (P < 0.05), and the level of plasma prolactin after operation was obviously increased due to the control group (P < 0.05). The colostrum time of the observation group was significantly shorter than that of the control group (P < 0.05), and the number of breast feeding was significantly higher than that of the control group (P < 0.05).
Conclusion:
Sufentanil combined with ropivacaine epidural analgesia can effectively relieve the pain after cesarean section, improve prolactin levels in maternal blood, improve breast milk status, and have no adverse effects on the newborn.
2017 Vol. 23 (6): 948-950 [
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128
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951
The Comparison of Inferior Vena Cava by Direct and Indirect 64-slice spiral CT Phlebography
CAO Hongwei, XING Yuanyuan, CHOU Heng-zhi, et al
DOI: 10.3969/j.issn.1006-6233.2017.06.021
Objective:
By compare the inferior vena cava diameters,CT value,image quality of direct and indirect 64-slice spiral CT angiography , analysis whether there is an advantage of direct.
Method:
Collecting 30 cases which were underwent direct inferior vena cava phlebography; and collecting 30 cases of whole abdominal contrast enhanced CT, get the venous phase image. Original datas were transferred to GE adw4.6 workstation for post-processing. The major axis、minor axis 、CT value were individually measured, at the levels of its entrance to the right atrium, the portahepatis, the renal pelvis, above the junction of iliac vein. The image quality of inferior vena cava (IVC) was evaluated by two physicians with more than 5 years experience. The results of the two groups were compared and statistically analyzed.
Result:
At the levels of its entrance to the right atrium, the portahepatis, the renal pelvis, above the junction of iliac vein, the major axis, minor axis of direct CT phlebography individually were (3.02±0.44, 2.06±0.32), (2.29±0.49, 1.39±0.52), (2.46±0.44, 1.73±0.45), (2.30±0.38, 1.66±0.46), of indirect phlebography individually were (2.88±0.43, 1.95±0.31), (2.37±0.59, 1.17±0.37), (2.28±0.32, 1.63±0.31), (2.25±0.21, 1.47±0.34), there is no obviously difference between them. The CT values of direct CTP were (232.57±59.45)、(278.10±80.00)、(360.32±92.13)、(466.78±100.71)HU, much higher than the indirect CTP (122.45±16.10)、(107.10±13.32)、(92.46±12.93)、(88.23±12.62)HU. Image quality better than good of direct CTP is 93.3%, much higher than indirect CTP 56.6%.
Conclusion:
Multi slice spiral CT direct CTP of IVC is feasible and superior to indirect CTP. It can obtain better image quality and can be used to diagnose the IVC diseases.
2017 Vol. 23 (6): 951-954 [
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136
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955
Effect of Addie Combined with FOLFOX4 in the Treatment of Colon Cancer and its Effect on Immune Function and Inflammatory Reaction
SONG Fei
DOI: 10.3969/j.issn.1006-6233.2017.06.022
Objective:
To investigate the effect of Addie combined with FOLFOX4 in the treatment of colon cancer and its effect on immune function and inflammatory reaction.
Method:
59 patients with colon cancer in our hospital were randomly divided into the experimental group and the control group. In the control group, 28 cases were treated with FOLFOX4 chemotherapy after operation, while 31 cases in the experimental group was treated with Addie injection combined with FOLFOX4 chemotherapy after operation. The clinical efficacy of the two groups and the immune function and inflammatory reaction before and after treatment were compared.
Results:
The total effective rate of the experimental group was 93.5% higher than that of the control group (78.6%), and the difference was statistically significant (P<0.05); Compared with the control group, the incidence of side effects was lower in the experimental group, the difference was statistically significant (P<0.05); The levels of IgA, IgG and IgM in the experimental group were higher, and the level of IL-6 was lower, the difference was statistically significant (P<0.05).
Conclusion:
Addie combined with FOLFOX4 in the treatment of colon cancer patients can reduce the damage to the immune system function, clinical effect is good, and greatly improved the quality of life of patients, reduce inflammatory response.
2017 Vol. 23 (6): 955-958 [
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147
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959
Application of Progesterone in the Treatment of Abnormal Uterine Bleeding Caused by Ovulation
SHEN Liyong, et al
DOI: 10.3969/j.issn.1006-6233.2017.06.023
Objective:
To research the clinical efficacy of dydrogesterone in the abnormal uterine bleeding of Ovulation disorder type (AUB-O).
Methods:
80 patients with AUB-O who were treated in our hospital from January 2013 to January 2015 were divided into A and B groups with the method of random number table, 40 patients in each group. Group A was received low-dose Mifepristone and group B was treated with Dydrogesterone, the therapeutic effects of the two groups were compared.
Results:
After treatment, the menstrual blood volume, two groups of patients with endometrial thickness and Hb concentration were significantly improved after treatment (P<0.05), and group B improved more significantly, and group A had significant difference (P<0.05); group B total effective rate was significantly higher than that of A group (P<0.05); the incidence of adverse reactions in group B significantly lower than group A (P<0.05).
Conclusion:
Mifepristone and Dydrogesterone can effectively treat AUB-O, but the latter is more advantageous in reducing menstrual quantity, endometrial thickness and adverse reactions, and increasing Hb concentration, is worth a recommendation.
2017 Vol. 23 (6): 959-961 [
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137
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962
Effect of Hydroxyethyl Starch 130.4 Electrolyte Injection and 130.4 Sodium Chloride Hydroxyethyl Starch on Blood Coagulation Function in Patients with Septic Shock, Oxidative Stress and Hemodynamics
LU Yan, WANG Liwei, et al
DOI: 10.3969/j.issn.1006-6233.2017.06.024
Objective:
To investigate the effect of hydroxyethyl starch 130.4 electrolyte injection and 130.4 sodium chloride hydroxyethyl starch on blood coagulation function in patients with septic shock, oxidative stress and hemodynamics.
Methods:
86 cases septic shock admitted in our hospital from September 2015 to September 2016 were randomly divided into observation group and control group, each of 43 cases. The observation group was received with 130.4 hydroxyethyl starch electrolyte injection for recovery and the control group was treated by using hydroxyethyl starch 130.4 sodium chloride for recovery. The levels of stress product of hemodynamics and coagulation function of two groups were compared.
Results:
After the recovery of the two groups of patients with MDA and AOPP levels decreased, the observation group was 16.44±1.9, 35.6 ± 5.6, were significantly lower than before treatment and the patients in the control group; after the recovery of antioxidant levels in two groups of GSH-PX and SOD levels were increased, the observation group were 242.6±31.3 and 29.7±2.2. But was significantly higher than the control group; two patients in group BT, PT, APTT and TT levels compared to no difference in recovery, after the recovery of the patients in the observation group BT, PT, APTT, TT levels were 129.5±39.8,13.3±0.9,31.7±2.9,17.7±1.8,significantly lower than the control group patients in the control group, difference significant. After treatment, the levels of EVLWI and CVP were significantly decreased in both groups, and the levels of were significantly higher than those before treatment, and the levels of MAP were significantly higher than those before treatment, but there was no difference between the two groups.
Conclusion:
130.4 electrolyte injection infection of fluid resuscitation in patients with septic shock by hydroxyethyl starch helps to reduce the oxidative stress reaction of patients, correct blood coagulation function disorder, which has no obvious effect on the hemodynamics index.
2017 Vol. 23 (6): 962-964 [
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132
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965
Study on the Relationship between the Pregnancy Outcome and Group B Streptococcus of Pregnancy in Qianjiang
LIU Ni, PI Dan, FENG Cuirong, et al
DOI: 10.3969/j.issn.1006-6233.2017.06.025
Objective:
To investigate the relationship between the pregnancy outcome and group B streptococcus of pregnancy in Qianjiang.
Methods:
800 cases of single fetal intrauterine pregnant women who taken regular prenatal in our hospital were included in the study, all of the pregnant woman were taken in B streptococcus routine detection, then they were divided into GBS positive group and GBS negative group according to the results. The perinatal outcomes of two groups were compared.
Resluts:
57 cases were infected GBS, the GBS positive rate was 7.1%. The rate of abortion, intrauterine infection, amniotic fluid contamination, postpartum hemorrhage, fetal infection and fetal distress of GBS positive group were significantly higher than the GBS negative group. Spearman correlation analysis showed that GBS had positive correlation with abortion, intrauterine infection, amniotic fluid contamination, fetal infection and fetal distress(r =2.306, 5.230, 4.052, 2.548, 3.647, P<0.05).
Conclusions:
Group B streptococcus can increase the incidence rate of abortion, intrauterine infection, amniotic fluid contamination, fetal infection and fetal distress, had bad effect on pregnancy outcome, should be taken into consideration seriously.
2017 Vol. 23 (6): 965-967 [
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164
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1026
Silver Ion Gel Combined with Fufang Shajiziyou Suppository for 124 Cases of Senile Vaginitis
HUANG Xiuli, LIANG Shiping, WANG Liping
DOI: 10.3969/j.issn.1006-6233.2017.06.045
Objective:
To observe the clinical effect of Silver ion gel combined with Fufang shajiziyou suppository for senile vaginitis.
Methods:
124 senile vaginitis from January 2014 to March 2016 were included and were treated with Silver ion gel combined with Fufang shajiziyou suppository. The clinical effect, vagina cleaness,side effect and recurrence were observed.
Results:
64 patients were cured, 52 patients were effective, 8 patietns were ineffective and the cure rate was 93.54%(116/124). The side effect rate was 4.84% and the vagina cleaness were improved compared with that before treatment(P＜0.05).After 5 month follow up visit, 4 patients recurrented.
Conclusion:
Silver ion gel combined with Fufang shajiziyou suppository for senile vaginitis has sound effect with less side effect and recurrence rate, it is worth spreading.
2017 Vol. 23 (6): 1026-1028 [
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192
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1040
Analysis of Pulmonary Function Values and its Influencing Factors of 600 Healthy School Children in Shijiazhuang
LIU Xiaojuan, ZHANG Zhongping, LIU Xinfeng, et al
DOI: 10.3969/j.issn.1006-6233.2017.06.051
Objective:
To explore the normal range and related factors in lung function of 6~12 years old healthy school-age children in Shijiazhuang City.
Methods:
A stratified sample of 600 cases in Shijiazhuang city of healthy children selected as the research object. And the main index from each child's age, sex, height, weight and other general demographic data and 5 pulmonary function: vital capacity (VC), forced vital capacity (FVC), one second forced expiratory volume (FEV1), peak expiratory flow (PEF), maximal midexpiratory flow (MMEF) were collected. And the research data were statistical analyzed.
Results:
For 600 children, an average of VC was 2.05L, FVC was 1.83L, FEV1 was 1.65L, PEF was 2.32L, MMEF was 1.64L. The 5 indicators showed that the male was higher than female (Tong Ling), and the trend of increasing with age. VC, FVC, FEV1, PEF and age, height are closely related, MMEF and height are closely related, have a positive correlation between the 5 indicators are closely related to gender, boys of the lung function indicators were higher than girls in the 5n.
Conclusion:
Lung function of healthy school-age children increased with age, lung function and age boys are higher than girls. Different factors influence lung function of the same failure, age, height and sex are the main factors.
2017 Vol. 23 (6): 1040-1042 [
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145
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1052
Effect of Exercise Rehabilitation Nursing on Cardiac Function and Quality of Life in Elderly Patients with Chronic Heart Failure
ZHAO Li
DOI: 10.3969/j.issn.1006-6233.2017.06.055
Objective:
To explore the effect of exercise rehabilitation nursing on cardiac function and quality of life in elderly patients with chronic heart failure.
Methods:
80 patients with heart failure admitted in our hospital from May 2015 to December 2016 were randomly divided into control group and observation group, each group of 40 patients. The patients of the control group were given routine treatment and care; and the patients in the observation group were treated with exercise rehabilitation on the basis of routine nursing treatment. The indexes of cardiac function evaluation, 6 min walking distance and quality of life were analyzed and compared between the two groups before and after treatment and 6 months follow-up.
Results:
The indexes of cardiac function in the observation group were significantly better than those in the control group, the difference was statistically significant (P <0.05);(P <0.05). The quality of life of the observation group was significantly higher than that of the control group (P <0.05). The difference was statistically significant (P <0.05). The quality of life was significantly higher in the observation group than in the control group at 6 min walking distance, exercise storage and plasma brain natriuretic peptide (P <0.05).
Conclusion:
Exercise rehabilitation and rehabilitation of elderly patients with chronic heart failure can effectively improve the heart function. And it has a very positive significance to improve the quality of life of patients.
2017 Vol. 23 (6): 1052-1054 [
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118
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