结直肠癌患者血清脂联素瘦素及其受体表达与临床病理参数的关系

doi:10.3969/j.issn.1006-6233.2018.07.016

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Abstract Objective: To investigate the risk, development and metastasis of Adiponectin (ADPN), adiponectin receptor 2 (adipoR2), Leptin (LP) and leptin receptor (LEPR) in patients with colorectal cancer. Methods: 43 patients with colorectal cancer hospitalized in the proctology department of our hospital and confirmed by pathology (tumor type, cell morphology and invasion depth) were enrolled into case group, 31 healthy individuals were included into control group, the general clinical data of all the selected subjects were collected. The levels of ADPN and LP in serum were measured by ELISA, and the expression of adipoR2 and LEPR mRNA was detected by RT-PCR. Results: The BMI, FBG, TC, HDL-C, LDL-C and TG between the two groups had no significant difference (t=0.78, 0.23, 0.64, 0.93, 0.19, 0.99, P>0.05), the prevalence rate of colorectal cancer in patients with family history of colorectal cancer was higher than those patients without the family disease history, the differences were statistically significant (χ²=12.13, P<0.05); The ADPN levels and adipoR2 mRNA expression level in serum were lower than those in the control group, and the LP levels and LEPR mRNA expression level in serum were higher than those in the control group (t=2.53, 4.29, 4.75, 6.24, P<0.05); Compared with patients in stageⅠ, The ADPN levels and adipoR2 mRNA expression level in serum decreased with the increase of TNM staging in colorectal cancer, and the LP levels and LEPR mRNA expression level in serum increased with the increase of TNM staging in colorectal cancer (F=9.90, 3.52, 8.70, 9.21, P<0.05); The ADPN levels and adipoR2 mRNA expression level in serum were negatively correlated with TNM stage (r=-0.335, -0.341, -0.557, -0.492, -0.665, -0.757, -0.815, -0.753, P<0.05), while the LP levels and LEPR mRNA expression level were positively correlated with TNM stage (r=0.396, 0.516, 0.510, 0.641, 0.642, 0.628, 0.695, 0.682, P<0.05). Conclusion: ADPN levels and LP levels and their receptor expression can be used as a marker for the diagnosis of colorectal cancer. In colorectal cancer patients, the level of ADPN and its receptor expression are significantly decreased, and the level of LP and its receptor expression are increased significantly.

Key words： Colorectal cancer ADPN AdipoR2 LP LEPR

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2018.07.016 OR http://www.hbyxzzs.cn/EN/Y2018/V24/I7/1121

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