丹参多酚酸盐联合甲钴胺对糖尿病周围神经病变患者血清IGF-1 IGFBP-1 BDNF MBP及周围神经传导速度的影响

doi:10.3969/j.issn.1006-6233.2018.07.012

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Abstract Objective: To study the effects of salvianolate combined with mecobalamin on serum insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 1 (IGFBP-1), human brain-derived neurotrophic factor (BDNF ), Human myelin basic protein (MBP) and peripheral nerve conduction velocity. Methods: A total of 136 patients with diabetic peripheral neuropathy who were treated in our hospital from September 2015 to October 2017 were selected for study. They were randomized into observation group (69 cases) and control group (67 cases). The patients in the control group were treated with mecobalamin, while the observation group was treated with salvianolate in the control group. The IGF-1, IGFBP-1, BDNF, MBP, MCV, SCV, fasting blood glucose, and postprandial blood glucose levels were recorded before treatment, 10 days after treatment, and 20 days after treatment, as well as the quality of life after treatment. And compare the two groups of changes, and then make a comprehensive evaluation of clinical efficacy. Results: The total effective rate in the observation group was significantly higher than that in the control group [92.75%>76.12%] (P<0.05); at 10 days after treatment and 20 days after the treatment, the levels of IGF-1, BDNF, MCV, and SCV were higher in the two groups of patients. Significantly increased before treatment, and the observation group was higher than the control group (P<0.05); IGFBP-1, MBP, fasting blood glucose, 2h postprandial blood glucose levels and quality of life scores were significantly lower in the two groups than before treatment, and the observation group Lower than the control group (P<0.05). Conclusion: Salviae miltiorrhizae polyphenols combined with mecobalamin treatment of diabetic peripheral neuropathy patients with significant clinical efficacy, not only can improve serum IGF-1, IGFBP-1, BDNF, MBP levels, but also regulate the peripheral nerve conduction velocity and improve quality of life.

Key words： Salvianolate Mecobalamin DPN

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	Articles by authors
	KE Li Mu-Palida
	BAI Tingdina
	MAO Wenjuan

Cite this article:

KE Li Mu-Palida,BAI Tingdina,MAO Wenjuan. Effects of Salvianolate Combined with Mecobalamin on Serum IGF-1 IGFBP-1 BDNF MBP and Peripheral Nerve Conduction Velocity in Patients with Diabetic Peripheral Neuropathy[J]. HeBei Med, 2018, 24(7): 1104-1107.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2018.07.012 OR http://www.hbyxzzs.cn/EN/Y2018/V24/I7/1104

[1] Almobarak AO, Noor SK, Elmadhoun WM,et al. Metabolic control targets in sudanese adults with type 1 diabetes: a population-based study[J].Family Med Prim Care,2017,6(2):374~379.
[2] 施君,张文川.糖尿病周围神经病变发病机制的研究进展[J].上海交通大学学报(医学版),2012,32(1):116~119.
[3] 鲍娟,唐彦,谈跃,等.糖尿病周围神经病变临床诊断方法的价值评估[J].中国糖尿病杂志,2014,22(2):122~125.
[4] 梁峰,胡大一,沈珠军,等.2014美国糖尿病指南:糖尿病诊疗标准[J].中华临床医师杂志(电子版),2014,8(6):1182~1190.
[5] Javed S , Alam U , Malik RA,et al. Burning through the pain: treatments for diabetic neuropathy[J].Diabetes, obesity & metabolism,2015, 17 (12):1115~1125.
[6] 张涛静,龚燕冰,周晖,等.糖尿病周围神经病变的中西医诊治[J].中华中医药杂志,2014,29(8):2433~2436.
[7] 桂伟,胡霞,唐宏图,等.中西医结合治疗糖尿病周围神经病变的临床研究[J].辽宁中医杂志,2016,43(1):101~103.
[8] Nathan HJ, Poulin P, Wozny D,et al. Randomized trial of the effect of mindfulness-based stress reduction on pain-related disability, pain intensity, health-related quality of life, and A1C in patients with painful diabetic peripheral neuropathy[J].Clin Diabetes,2017,35(5):294~304.
[9] Srinivasan S, Dehghani C, Pritchard N,et al. Corneal and retinal neuronal degeneration in early stages of diabetic retinopathy[J].Invest Ophthalmol Vis Sci,2017,58(14):6365~6373.
[10] Sun J, Zheng H, Qin X,et al. Effects of immunocytokine combined with cattle encephalon glycoside and Ignotin on CTGF, HO-1 and NT-3 in patients with type 2 diabetic peripheral neuropathy[J].Iran Public Health,2017,46(12):1632~1638.
[11] 卢伟波,杨丕坚,李舒敏,等.丹参多酚酸盐对早期糖尿病肾病患者炎症细胞因子及肾血管内皮功能的影响[J].中国实验方剂学杂志,2014,20(2):184~187.
[12] 赵云平.丹红注射液联合西药对糖尿病周围神经病变神经传导速度及神经生长相关因子的影响观察[J].世界中医药,2013,8(7):750~752.