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| Effects of Enoxaparin Combined with Ulinastatin on the Thrombogenesis and Serum RANKL, OPG and MMP-9 Levels of Patients after Knee Arthroplasty |
| PENG Xiong, CHEN Jialian |
| Hanchuan People's Hospital, Hubei Hanchuan 431600, China |
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Abstract Objective: To study the effect of enoxaparin combined with ulinastatin on the thrombus prophylaxis and the serum factor-1 receptor activator ligand (RANKL), osteoprotegerin (OPG), matrix metalloproteinase -9 (MMP-9) levels of patients after knee arthroplasty. Methods: From July 2015 to June 2016, 80 patients with knee replacement were included in this study in our hospital, and divided into the observation group and control group according to the admission order with 43 cases in each group. The control group was treated with enoxaparin sodium for injection on the basis of knee arthroplasty. The observation group was treated with ulinastatin on the basis of control group. The changes of serum PANKL, OPG, MMP-9 levels, coagulation function indexes before and after treatment, postoperative thrombosis and the incidence of adverse reactions were compared between the two groups. Results: The levels of serum PANKL, OPG and MMP-9 in the two groups after treatment were significantly lower than those before operation (P <0.05). Compared with the control group, the serum PANKL level in the observation group was higher (P <0.05), the serum OPG and MMP-9 levels were lower (P <0.05). There was no significant difference in the D-dimer, platelet, partial thromboplastin time, calf muscle vein thrombosis, deep vein thrombosis and thrombosis length between the two groups (P> 0.05). The proportion of thrombus, the total length of the thrombus, the number of thrombosis in the observation group were significantly lower than those of the control group (P<0.05). The was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Enoxaparin combined with ulinastatin can effectively prevent the thrombogenesis of lower extremities after knee arthroplasty, which can effectively reduce the serum levels of PANKL, OPG and MMP-9 with high safety.
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2018, Vol. 24 
