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| Expression of KI67 Protein in Ovarian Cancer and its Correlation with Clinicopathological Features and Prognosis |
| MA Chunyan |
| Chengde County Hospital of Traditional Chinese Medicine, Hebei Chengde County 067400, China |
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Abstract Objective: To investigate the expression of KI67 protein in ovarian cancer and its correlation with clinicopathological features and prognosis. Methods: 60 patients with ovarian cancer admitted to our hospital from January 2013 to December 2014 were selected as the study subjects, and 30 patients with benign ovarian tumors treated in the same period were selected as the control group. The expression of KI67 protein in different ovarian tissues was measured by immunofluorescence labeling, and its correlation with clinicopathological characteristics and prognosis was further analyzed. Result: The expression level of KI67 protein in ovarian cancer tissue was higher than that in benign ovarian tumor tissue and normal ovarian tissue, while that in benign ovarian tumor tissue was higher than that in normal ovarian tissue (P<0.05). The expression level of KI67 protein in ovarian cancer tissues of patients with ovarian cancer was higher than that of patients with tumor diameter > 3cm than that of patients with tumor diameter > 3cm, TNM stage > (III+ IV) than (I+ II), low differentiation than high and moderate differentiation (P<0.05). Within 4 years, the expression level of KI67 protein in the death group was higher than that in the survival group (P<0.05). Conclusion: KI67 protein is highly expressed in ovarian cancer tissues and is associated with the occurrence, development and prognosis of ovarian cancer.
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2019, Vol. 25 
