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| Effect of Mexiletine Combined with Shensong Yangxin Capsule on Heart Function and Therapeutic Effect of NSTEMI Patients with Arrhythmia |
| WANG Feng, MA Fengyun, ZHAO Xizhe |
| Beijing Electric Power Hospital of State Grid Corporation of China, Beijing 100073, China |
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Abstract Objective: To analyze the effect of mexiletine combined with Shensong Yangxin capsule on therapeutic effect and cardiac function in patients with non-ST-segment elevation myocardial infarction (NSTEMI) complicated with arrhythmia. Methods: 178 NSTEMI outpatients with arrhythmia from June 2015 to June 2018 in our hospital were selected as the research subjects. According to the randomized parallel control design and simple random grouping method, the patients were divided into control group treated with mexiletine and study group treated with mexiletine combined with Shensong Yangxincapsule, with 89 cases in each group. The clinical efficacy, electrocardiogram indexes, cardiac function indexes before and after treatment and adverse reactions during treatment were compared between the two groups. Results: The total effective rate of the study group was 97.75%, which was significantly increased compared with 86.52% of the control group (P<0.05). Compared with before treatment, standard diviation of NN intervals (SDNN) and standard diviation average of NN intervals (SDANN) were significantly increased in both groups after treatment (P<0.05), but there was no significant difference between the study group and the control group after treatment (P>0.05). Compared with before treatment, the levels of left ventricular ejection fraction (LVEF), left ventricular systolic diameter (LVDs) and left ventricular diastolic diameter (LVDd) in the two groups were significantly increased after treatment, and the levels in the study group were significantly increased compared with control group after treatment(P<0.05). The incidence of adverse reactions was 3.37% in the study group and 6.74% in the control group, which showed no significant difference between the two groups (P>0.05). Conclusion: Mexiletine combined with Shensong Yangxin capsule can effectively improve the clinical efficacy of NSTEMI patients with arrhythmia. It plays an important role in improving cardiac function and anti-arrhythmia, and does not cause serious adverse reactions. It suggests that this therapy has good drug safety and is worthy of clinical application.
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2019, Vol. 25 
