|
|
|
| Effects of Selegiline Combined with Pramipexole on Behavioral and Psychological Symptoms Cognitive Disorders and ADL of Patients with Parkinson's Disease Complicated with Sleep Disorders |
| WANG Yang, XU Bing, ZHOU Jin, et al |
| Shenyang First People's Hospital, Liaoning Shenyang 110041, China |
|
|
|
|
Abstract Objective: To investigate the effects of selegiline combined with pramipexole on behavioral and psychological symptoms, cognitive disorders and activity of daily living of patients with Parkinson's disease (PD) complicated with sleep disorders. Methods: 80 patients with PD and sleep disorders in the hospital were divided into control group (n=40) and observation group (n=40) by the simple random grouping method. The control group was treated with pramipexole while the observation group was treated with selegiline combined with pramipexole. Scores of neuropsychiatric inventory (NPI), mini-mental state examination (MMSE), Pittsburgh sleep quality index (PSQI), Epworth sleepiness scale (ESS), Unified Parkinson’s Disease Rating Scale (UPDRS-III) and activities of daily living (ADL), as well as adverse reactions were compared between the two groups. Results: Scores of NPI, PSQI, ESS and UPDRS-III of the observation group were lower than those of the control group after treatment (P<0.05), while scores of MMSE and ADL were higher than those of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Selegiline combined with pramipexole can significantly improve the behavioral and psychological symptoms of patients with PD and sleep disorders, reduce cognitive disorders, and enhance activity of daily living, without obvious adverse reactions.
|
|
|
|
|
|
[1] 周柏玉,周宇杰,王玉香.帕金森病临床治疗方法的研究进展[J].神经解剖学杂志,2014,30(4):495~498.
[2] 吴少璞,李学,祁亚伟.音乐联合心理治疗对伴睡眠障碍帕金森病患者多导睡眠图的影响[J].中华物理医学与康复杂志,2017,39(1):48~51.
[3] 尤林,白抚生,韩艳丽,等.帕金森病患者睡眠障碍临床特点及相关因素[J].中国公共卫生,2018,34(1):121~122.
[4] 苏娜,吴斌,徐珽.司来吉兰治疗帕金森病的有效性与安全性的系统评价[J].中国医院药学杂志,2014,34(14):1206~1212.
[5] 陈生弟.帕金森病[M].北京:人民卫生出版社,2006.20~22.
[6] 李燕,余刚.载脂蛋白AI在帕金森病发病中的作用及临床价值[J].中风与神经疾病杂志,2015,32(6):573~574.
[7] 李敦辉,吴丽,周海燕,等.表观遗传学在帕金森病发病机制中的研究进展[J].临床神经病学杂志,2015,28(4):312~313.
[8] 牛晓波,缑元冲.帕金森病睡眠障碍影响因素分析[J].脑与神经疾病杂志,2015,23(5):353~358.
[9] 刘宇翔,刘振华,等.帕金森病患者认知功能障碍的神经精神症状分析[J].中国现代医学杂志,2016,26(10):61~66. |
|
|
|
2019, Vol. 25 
