曲美布汀联合阿普唑仑对腹泻型IBS患者血清炎性因子及胃肠激素的临床研究

doi:10.3969/j.issn.1006-6233.2017.11.011

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Abstract Objective: To evaluate the effect of trimebutine combined with alprazolam on serum inflammatory factor, immune function, gastrointestinal hormone, ghrelin and quality of life of IBS-D patients. Methods: 117 cases of IBS-D were randomly divided into control group (n=58) and treatment group (n=59).The control group was only given trimebutine treatment, the treatment group was treated with trimebutine combined with alprazolam, 2 groups were consecutively treated for 4 weeks. Detected and compared of the 2 groups of serum inflammatory factors, immune function, gastrointestinal hormon, ghrelin and quality of life changes before and after treatment; Statistics and analysis of 2 groups of SF-36 quality of life scores before and after treatment. Results: After treatment, the MOT, GAS, SP, 5-HT, IL-8, IL-12, CD8⁺T cell ratio of 2 groups were significantly decreased (P<0.05 or P<0.01), VIP, SS, CCK, CGRP, IL-10, CD3⁺, CD4⁺, CD4⁺/CD8⁺ and SF-36 scores increased significantly (P<0.05 or P<0.01), and the difference between 2 groups was significant (P<0.05 or P<0.01). Conclusion: Trimebutine combined with alprazolam can significantly improve gastrointestinal peristaltic function of IBS-D patients, balance the level of inflammatory cytokines, improve the immune function and quality of life, with significant curative effect and worthy of clinical application.

Key words： Trimebutine Alprazolam IBS-D Gastrointestinal hormone Ghrelin

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2017.11.011 OR http://www.hbyxzzs.cn/EN/Y2017/V23/I11/1799

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