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| Preventive Effect of Xuebijing Injection on Sepsis in Patients with Severe Burn and Its Effect on Inflammatory Factors |
| SUN Tongzu |
| The Third People's Hospital of Jingzhou, Hubei Jingzhou 434000, China |
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Abstract Objective: To explore the preventive effect of Xuebijing injection on sepsis in severely burned patients and its effect on inflammatory factors. Methods: A total of 84 patients with severe burns admitted to our hospital from July 2015 to December 2017 were divided into observation group and control group by simple random grouping, with 42 cases in each group. After admission, both groups were treated with conventional burns, including: nutritional support, organ protection, fluid resuscitation, antibiotics, and conventional wound debridement and dressing change. On the basis of this, the observation group applied Xuebijing injection: 50 ml/time, twice/d for 1 week. The incidence of sepsis, serum levels of creatinine (Cr), urea nitrogen (BUN), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), acute physiology and chronic health (APACHE) score, sequential organ failure score (SOFA) at the time of admission and 1 week of treatmentwere compared between the two groups. Results: The incidence of sepsis in the observation group was 11.90% (5/42), and 30.95% (13/42) in the control group, the difference was statistically significant (P<0.05). There were no significant differences in serum levels of TNF-α, IL-6, Cr, BUN, APACHE scores, and SOFA scores between the two groups (P>0.05). After 1 week of treatment, the serum levels of TNF-α, IL-6, Cr, BUN, APACHE and SOFA were significantly lower than those at admission in both group (P<0.05). The serumlevels of TNF-α, IL-6, Cr, BUN, APACHEscore and SOFA scoreat 1 week of treatmentin the observation group were significantly lower than those in the control group(P<0.05). Conclusion: On the basis of routine treatment of western medicine, Xuebijing injection can treat severe burns, which can effectively improve the overall physiological condition of patients, inhibit inflammatory factors, block inflammatory damage induced by inflammatory transmitters, protect kidney function and prevent the occurrence of sepsis, the effect is significant, it is worth promoting.
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2019, Vol. 25 
