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| Effects of Mechanical Ventilation Combined with High-dose Ambroxol on Plasma PCT and CRP Levels in Elderly Patients with Severe Pulmonary Infection |
| CAI Rong |
| Maanshan Seventeen Metallurgical Hospital, Anhui Maanshan 243000, China |
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Abstract Objective: To explore the effects of mechanical ventilation combined with high-dose ambroxol on elderly patients with severe pulmonary infection. Methods: 84 cases of elderly patients with severe pulmonary infection who were admitted between January 2016 and June 2018 were divided into observation group and control group according to the simple random sampling, with 42 cases in each group. Control group was given mechanical ventilation combined with conventional-dose ambroxol, and observation group was given mechanical ventilation combined with high-dose ambroxol. The clinical efficacy, symptoms improvement times and mechanical ventilation time were compared between the two groups. The blood gas analysis indexes [arterial partial pressure of oxygen (PaO2), arterial oxygen saturation (SaO2), oxidation index (PaO2/FiO2)] were evaluated before treatment and after 1 w of treatment, and the inflammatory indexes [procalcitonin (PCT), C-reactive protein (CRP)] were evaluated before treatment and after 2 w of treatment. Results: After 2 w of intervention, the total effective rate of treatment in observation group was higher than that in control group (P<0.05). The symptoms improvement times of fever, cough, shortness of breath and lung wet rales and the mechanical ventilation time in observation group were shorter than those in control group (P<0.05). After 1 w of treatment, the PaO2, SaO2 and PaO2/FiO2 in the two groups were higher than those before treatment (P<0.05), and the increases in observation group were greater than those in control group (P<0.05). After 2 w of treatment, the levels of PCT and CRP in the two groups were lower than those before treatment (P<0.05), and the decreases in observation group were greater than those in control group (P<0.05). Conclusions: Mechanical ventilation combined with high-dose ambroxol has good effects in the treatment of elderly patients with severe pneumonia, and it is beneficial to control the levels of PCT and CRP.
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2019, Vol. 25 
