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| Curative efficacy of Seretide combined with Standard Myrtle oil Enteric-coated Capsule in Treatment of Chronic Obstructive Pulmonary Disease and Effects on Serum SIRT1 sfrp5 and MRpro-ADM Levels |
| ZHENG Li, CHEN Caiming, TANG Yuechan |
| Jiangbin Hospital of Guangxi Zhuang Autonomous Region, Guangxi Nanning 530021, China |
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Abstract Objective: To investigate the efficacy of seretide combined with standard Myrtle oil enteric-coated capsule in the treatment of chronic obstructive pulmonary disease and its effects on serum SIRT1, Sfrp5 and MRpro-ADM. Methods: 100 patients of chronic obstructive pulmonary disease who received therapy from April 2016 to April 2018 in our hospital were selected as research objects, they were divided into observation group (55 cases) and control group (45 cases) by the simple random number table method, On the basis of routine treatment, the control group was treated with seretide while the observation group was treated with Standard Myrtle oil enteric-coated on the basis of the control group, they were treated for 8 weeks. The clinical efficacy, serum SIRT1, sfrp5, MRpro-ADM, lung function, respiratory questionnaire (mMRC) score and adverse reactions were compared between the two groups. Results: After treatment, the total effective rate of the observation group was significantly higher than those in the control group(P＜0.05); the serum SIRT1 and Sfrp5 levels in the observation group were significantly higher than those in the control group, and MRpro-ADM levels was significantly lower than those in the control group(P＜0.05); the first second forced expiratory volume (FEV1) and FEV1/forced vital capacity (FVC) in the observation group were significantly higher than those in the control group(P＜0.05); the mMRC score of the observation group was significantly lower than those in the control group(P＜0.05); there was no significant difference in the incidence of adverse reactions between the two groups during treatment(P>0.05). Conclusion: Seretide combined with standard Myrtle oil enteric-coated capsule has remarkable effect on chronic obstructive pulmonary disease. It can effectively regulate the expression of SIRT1, Sfrp5 and MRpro-ADM in serum, alleviate airway inflammation and improve lung function. It has high clinical value.
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2019, Vol. 25 
