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| Effect of Gemcitabine combined with DF Chemotherapy Regimen on 3D-CRT Therapy on Serum VEGF and MMP-9 Levels in Patients after Cervical Cancer Surgery |
| YAN Jun, CAO Chun |
| Zigong First People's Hospital of Sichuan Province, Sichuan Zigong 643000, China |
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Abstract Objective: To investigate the effect of simultaneous three-dimensional conformal radiotherapy (3D-CRT) with gemcitabine combined with DF chemotherapy in patients with cervical cancer. Methods: A total of 90 patients with cervical cancer who underwent surgery from November 2013 to June 2015 were enrolled in our hospital. All patients were treated with synchronous 3D-CRT therapy, grouped according to random number table, 45 patients in the control group were treated with DF chemotherapy. 45 patients in the study group were treated with gemcitabine on the basis of the control group. The therapeutic effects and serum vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9) levels, and tumor suppressor genes (Fas, p53), the level of change, and the incidence of adverse reactions and prognosis (1 year, 2 years, 3 years) survival rate were compared before and after treatment. Results: The clinical efficacy of the observation group was better than that of the control group, and the disease control rate was 82.22% (37/45) in the observation group, 57.78% (26/45) in the control group (P<0.05). The levels of VEGF and MMP-9 were significantly lower than those before treatment, and the levels of serum VEGF and MMP-9 in the observation group were lower than those in the control group (P<0.05). The levels of Fas and p53 in the two groups were significantly higher than those before treatment. The levels of Fas and p53 in the observation group were higher than those in the control group (P<0.05). The observation group had leukopenia (26.67%), diarrhea (31.11%), nausea and vomiting (37.78%), thrombocytopenia (44.44%), and hair loss. The incidence rate of 57.78% was not significantly different from that of the control group (P>0.05). The 1-year survival rate of the observation group was 93.33% (42/45), and the 2-year survival rate was 84.44% (38/45). The annual survival rate was 64.44% (29/45). The 1-year survival rate of the control group was 91.11% (41/45), the 2-year survival rate was 80.00% (36/45), and the 3-year survival rate was 57.78% (26/45) There was no significant difference between the groups (P>0.05). Conclusion: Synchronous 3D-CRT therapy with gemcitabine combined with DF chemotherapy can improve serum VEGF and MMP-9 levels, up-regulate tumor suppressor gene expression, increase disease control rate, and have fewer adverse reactions.
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2019, Vol. 25 
