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| Analysis on the Effect of Methylpyridine combined with Mifepristone on Serum Progesterone and β-HCG Levels in Patients with Ectopic Pregnancy |
| LI Changhong, HUANG Zhanyi, et al |
| Hainan Maternal and Child Health Hospital, Hainan Haikou 570206, China |
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Abstract Objective: To study the effect of meteropteridine combined with mifepristone on serum progesterone and β-HCG levels in patients with ectopic pregnancy. Methods: 86 cases of ectopic pregnancy treated in our hospital from January 2016 to February 2017 were randomly divided into two groups: control group (methotrexate treatment) and observation group (methotrexate mifepristone treatment). Adverse reactions, mass, abdominal pain disappearance time, serum β-HCG negative time, progesterone recovery time and menstrual resuscitation time were analyzed in both groups. Results: The success rate in the observation group (95.35%) was significantly higher than that in the control group (74.42%) (P<0.05). In the observation group, the mass, the time of disappearance of abdominal pain, the negative time of serum β -HCG, the time of progesterone returning to normal and the time of menorrhagia were shorter than those of the control group (P<0.05). After treatment, the levels of serum progesterone and β-HCG in the observation group were lower than those in the control group (P<0. 05).But there was no significant difference in the rate of intrauterine pregnancy and the rate of ectopic pregnancy between the two groups within one year (P>0.05). Conclusion: Methamotrexil combined with mifepristone for ectopic pregnancy has a high success rate, rapid disappearance of clinical symptoms, little influence on fertility outcome, and high safety.
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2019, Vol. 25 
