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| Diagnostic Value of Lysophosphatidylcholines in Patients with Acute Myocardial Infarction |
| ZHANG Lei, et al |
| College of Chemical Engineering, Tianjin University, Tianjin 300072, China |
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Abstract Objective: To investigate the diagnostic value of lysophosphatidylcholine (LPCs) in acute myocardial infarction (AMI). Methods: From December 2015 to June 2016, a total of 44 AMI patients in Tianjin Third Central Hospital were recruited as AMI group. And 25 healthy individuals were selected as control group. According to the results of coronary angiography, the patients in AMI group were divided into anterior myocardial infarction AAMI patients (n=21) and inferior myocardial infarction AIMI patients (n=23). The biochemical parameters such as hs-CRP in the serum of each group were measured. The contents of five LPCs in LPC 14:0-LPC 18:0 were determined by UPLC-MS metabolomics platform. Principal Component Analysis (PCA) Model and Orthogonal Partial Least Squares Discriminant (OPLS-DA) Model were used to analyze serum metabolic profiles, and ROC Curves were used to analyze the potential diagnostic significance of five LPCs. Results: Fasting blood glucose (GLU) and triglyceride (TG) levels were significantly lower in AMI patients than in healthy subjects in Control group. Serum brain natriuretic peptide (BNP), high-sensitivity C-reactive protein (hs-CRP), creatine kinase (CK), and creatine kinase isoenzyme (CK-MB) levels were significantly higher (P<0.05). The levels of five LPCs in serum LPC 14:0-LPC 18:0 in AMI patients were also lower than those in healthy subjects (P<0.05). The metabolic profile can better distinguish between healthy subjects and AMI patients. All five LPCs have high diagnostic values for the diagnosis of AMI patients, especially LPC 15:0-LPC 18:0. LPC 14:0, LPC 15:0, LPC 17:0 and LPC 18:0 have high diagnostic value for distinguishing between AAMI and AIMI. The combination of LPC 14:0 and LPC 18:0 enables more efficient diagnosis of AAMI and AIMI. Conclusion: LPCs have high diagnostic values for AMI. Combination of different LPCs can more effectively diagnose AMI patients with different sites.
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[1] Okwuosa IS, Lewsey SC, Adesiyun T, et al. Worldwide disparities in cardiovascular disease: challenges and solutions[J]. Int Cardio, 2016, 202:433~440.
[2] Zhao Q, Xu H, Chen Z, et al. Changes in characteristics, risk factors and mortality among patients with acute myocardial infarction in the capital of china over 40 years[J]. Int Cardio, 2017, 32(265):30~34.
[3] 何梦玲,麦惠香.血清肌钙蛋白I和肌红蛋白检测在心肌梗死诊断中的应用价值分析[J].医学检验与临床,2017,28(1):41~42.
[4] 芦勤玮,佟玲,李东翔,等.复方丹参滴丸抗急性心肌梗死代谢组学研究[J].分析化学,2017,45(6):791~798.
[5] Dalen JE, Alpert JS, Goldberg RJ, et al. The epidemic of the 20(th) century: coronary heart disease[J]. Am Med, 2014, 127(9):807~812.
[6] Krautbauer S, Eisinger K, Wiest R, et al. Systemic saturated lysophosphatidylcholine is associated with hepatic function in patients with liver cirrhosis[J]. Prostaglandins Other Lipid Mediat, 2016, 124:27~33.
[7] 许文轩,连烁,稂与恒,等.急性心肌梗死血浆标志代谢物及相关代谢通路的筛选[J].山东医药,2018,57(7):23~27. |
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2019, Vol. 25 
