错配修复蛋白MLH1 MSH2 MSH6及PMS2 在结直肠癌中的表达及其临床意义

doi:10.3969/j.issn.1006-6233.2019.04.003

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Abstract Objective: To detect the expression of mismatch repair proteins(MLH1, MSH2, MSH6 and PMS2)in the colorectal cancer and disscus the correlation between the clinicopathological characteristics and MMR protein. Methods: EnVision immunohistochemical method was used to detect the expression of MMR protein, and then analyze the relationship between the expression of mismatch repair protein of CRC patients and pathology features from 242 cases of colorectal cancer. Results: ①In 242 cases of colorectal cancer patients, total expression deletion rate was 14.04%, the expression deletion rate was of MLH1, hMLH2, hMSH6 and hPMS2 protein was respectively 10.03% (25/242), 1.2% (3/242), 1.2% (3/242) and 11.16% (27/242). hMLH1 and hPMS2 co-expression deletion rate was 9.50%(23/242), hMSH2 and hMSH6 co-expression deletion rate was 0.83% (2/242). ②All of MMR protein expression deletion was uncorrelated with sexuality, age, lymphatic metastasis in CRC (p＞0.05), the expression of hMLH1 protein was related to the differentiation degree of CRC (p＜0.05), the expression of hPMS2 protein was related to the location, size and differentiation degree of tumor (p＜0.05). Conclusion: The location, size and differentiation of tumors affect the expression of mismatch repair proteins hMLH1 and hPMS2 in CCR. The co-expression of hMLH1 and hPMS2, hMSH2 and hMSH6 is more common, and the deletion of hMLH1 and hPMS2 is more common.

Key words： Colorectal cancer Mismatch repair protein Immunohistochemistry

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.04.003 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I4/536

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