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| Changes of Serum PCT, Endothelin, eNOS and NFκB levels in Patients with Intracranial Infection after Craniocerebral Trauma and their Clinical Significance |
| YIN Jie, MOLADING·Abulizi, ZHENG Xi |
| The 474 Hospital of PLA, Xinjiang Urumqi 830001, China |
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Abstract Objective: To investigate the changes of procalcitonin (PCT), endothelin (ET-1), endothelial nitric oxide synthase (eNOS) and nuclear factor (NFκB) levels in patients with intracranial infection after craniocerebral trauma and their clinical significance. Methods: 182 patients undergoing operation of traumatic brain injury and 30 healthy subjects were enrolled in the study. The patients were divided into infected group and uninfected group according to the criteria of intracranial infection. According to the anti-infective effect, patients in the infected group were divided into the controlled group and the uncontrolled group. Serum PCT, ET-1, eNOS and NFκB levels in each group were determined. The diagnostic efficiency of each index for infection was compared between groups. Results: Serum PCT, ET-1, eNOS and NFκB levels showed in the infected and uninfected groups were significantly higer than those in the control group (P<0.05). The levels of serum PCT, ET-1, eNOS and NFκB in the uncontrolled group were significantly higher than those in the controlled group (P<0.05). ROC curve analysis showed that the area under the curve of serum PCT was the largest and the diagnostic efficiency was the highest. With serum PCT =0.32μg/L as the best cut-off point, the diagnostic sensitivity and specificity were 88.6% and 91.6%, respectively. Conclusion: The levels of serum PCT can reflect the status of intracranial infection to a certain extent, and they can be used as reference indexes for the diagnosis of intracranial infection and evaluation of prognosis
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[1] 郑光辉,张国军,李方强,等.神经外科术后患者脑脊液培养凝固酶阴性葡萄球菌真感染诊断值的确定与临床意义[J].中华检验医学杂志,2017,40(9):112~114.
[2] 赵晖,张国军,刘志忠,等.神经外科手术后颅内感染早期脑脊液中IL-6、IL-8和TNF-α水平变化的意义[J].标记免疫分析与临床,2013,20(3):132~135.
[3] 张松坡,高玉松,胡承啸,等.神经外科手术后颅内感染患者病原菌分布及其影响因素研究[J].实用心脑肺血管病杂志,2016,5(1):29~32.
[4] 孙鑫晔,宇文利霞,李勇晋,等.脑脊液培养出肠杆菌科细菌对颅内感染诊断价值的探讨[J].河北医学,2016,22(11):1870~1872.
[5] 何炳灵,郭述良.降钙素原与临床肺部感染评分对老年呼吸机相关性肺炎患者病情严重程度及预后的评估价值[J].医学研究杂志,2016,45(4):49~52.
[6] 方黎晓,胡少玄,孙龙,等.脑外伤患者术后颅内感染病原菌分析与对一氧化氮及降钙素原水平影响研究[J].中华医院感染学杂志,2016,26(5):1095~1097.
[7] 武元星,郝京京,王强.血清及脑脊液降钙素原在神经外科术后颅内感染早期诊断中的应用[J].中国临床神经外科杂志,2017,9(4):237~238.
[8] 贺峰,孙晓东.血清C-反应蛋白、降钙素原及乳酸在脑外伤患者术后颅内感染诊断意义研究[J].安徽医药,2017,21(11):2035~2038.
[9] 张国新,隋明亮,张劲松.降钙素原对开颅术后颅内感染的早期诊断及预后预测价值[J].广东医学,2015,11(20):3152~3156. |
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2019, Vol. 25 
