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| Effect of Probiotic Enteral Nutrition Intervention on Intestinal Flora and Inflammatory State in Patients with Severe Cerebral Hemorrhage after Operation |
| LI Yuanyuan, Yanruiying, LI Dongchun, et al |
| Weinan Central Hospital, Shaanxi Weinan 714000, China |
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Abstract Objective: To explore the effect of enteral nutrition intervention with probiotics on intestinal flora and inflammatory status after critical cerebral hemorrhage surgery. Methods:86 cases of patients after critical cerebral hemorrhage surgery from January 2016 to January 2018 were divided into observation group and control group according to the simple random grouping, with 43 cases in each group. Control group was given gastric intubation of enteral nutrition intervention on the basis of conventional treatment, and observation group was supplemented with probiotics on the basis of control group. Nutritional status [serum total protein (TP), albumin (ALB), hemoglobin (HB)], intestinal flora distribution (Bifidobacterium, Lactobacillus, Enterobacter, Enterococcus), immune function (T lymphocyte subsets) and inflammatory status [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8)] were evaluated in the two groups before intervention and after 2 weeks of intervention. And the incidence rate of adverse events was compared between the two groups. Results:Before intervention, there were no significant differences in the levels of TP, ALB and HB between the two groups (P>0.05). Before intervention, there were no significant differences in the levels of TNF-α, IL-6 and IL-8 between the two groups (P>0.05). After 2w intervention, the levels of TP, ALB and HB in the two groups were higher than those before intervention (P<0.05) while the levels of TNF-α, IL-6 and IL-8 were lower than those before intervention (P<0.05), and the changes in observation group were greater than those in control group (P<0.05). Before intervention, there were no significant differences between the two groups in Bifidobacterium, Lactobacillus, Enterobacter and Enterococcus (P>0.05). After 2w of intervention, the Bifidobacterium and Lactobacillus in observation group were higher than those before intervention and those in control group at the same time period (P<0.05), and the Enterobacter and Enterococcus were lower than those before intervention and those in control group at the same time period (P<0.05). There was no statistically significant difference in the Bifidobacterium and Lactobacillus in control group compared with those before intervention (P>0.05). The Enterobacter and Enterococcus in control group were higher than those before intervention (P<0.05). Before intervention, there were no significant differences in CD3+, CD4+ and CD4+/CD8+ between the two groups (P>0.05). After 2w of intervention, the levels of CD3+, CD4+ and CD4+/CD8+ in the two groups were higher than those before intervention (P<0.05), and the increase in observation group was greater than that in control group (P<0.05). The CD8+ in observation group was lower than that before intervention and that in control group at the same time period (P<0.05). There was no significant difference in CD8+ before and after intervention in control group (P>0.05). The incidence rates of gastrointestinal hemorrhage and intestinal flora imbalance in observation group were lower than those in control group (P<0.05). There was no statistically significant difference in the incidence rate of pulmonary infection (P>0.05). Conclusions:Probiotic enteral nutrition intervention can improve nutritional status, intestinal flora, inflammatory status and immune function of patients with severe cerebral hemorrhage after operation, and reduce the risk of complications.
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[1] 刘卫东.高血压性脑出血的诊治进展[J].上海医学,2017,40(11):646~649.
[2] 吴自成,陈新成,黄启化,等.不同术式治疗重症高血压脑出血患者的效果比较[J].实用临床医药杂志,2016,20(21):86~87.
[3] 苏学艳,薛苏娟,李晓红,等.添加益生菌的肠内营养对老年骨折术后患者肠道菌群变化及预后的影响[J].河北医药,2017,39(12):1776~1779.
[4] 吴莉娟,李景萍,郭帮卫.添加双歧杆菌的肠内营养对重症脑卒中病人肠道菌群的影响[J].肠外与肠内营养,2016,23(4):220~222.
[5] 韩丽丽,刘银辉,赵利慧,等.肠道菌群紊乱对Treg细胞影响的研究进展[J].中国微生态学杂志,2017,29(1):101~105.
[6] 班碧秀.早期个体化肠内营养支持在重症脑出血术后患者中的应用[J].广西医科大学学报,2017,34(5):756~759.
[7] 张毅,王军,朱海龙,等.添加双歧杆菌的肠内营养干预对重症脑梗死患者营养状态及肠道菌群紊乱的影响[J].海南医学院学报,2017,23(12):1723~1725.
[8] 彭慧平,唐艳,董为为,等.肠道菌群对肠黏膜T淋巴细胞亚群的调节作用[J].中国微生态学杂志,2017,29(2):234~238. |
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2019, Vol. 25 
