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| Effect of Combined Treatment of Pulmonary Surfactant and Non-invasive High Frequency Oscillatory Ventilation on Neonatal Respiratory Distress Syndrome |
| FENG Aimin, XIE Xiuchun, WANG Miao, et al |
| The Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Shaanxi Xianyang 712000, China |
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Abstract Objective: To observe the efficacy of combined treatment of pulmonary surfactant and non-invasive high-frequency oscillatory ventilation in neonatal respiratory distress syndrome (NRDS). Methods: 80 cases of children patients with NRDS admitted to our hospital from May 2017 to April 2018 were selected for the study and were randomly divided into observation group and control group according to the random number table method, with 40 cases in each group. Control group was given conventional ventilation combined with pulmonary surfactant, and observation group was treated with non-invasive high-frequency oscillatory ventilation combined with pulmonary surfactant. The effective rate of treatment, general conditions and arterial blood gas indexes [arterial partial pressure of oxygen (PaO2), pH value, partial pressure of carbon dioxide (PaCO2), percentage of inhaled oxygen concentration (FiO2), oxygenation index (OI)] and the incidence rate of complications were recorded in the two groups. Results: The effective rate of treatment in observation group was higher than that in the control group (90.00% vs 70.00%) (P<0.05). The operative time, symptom relief time and hospital stay in observation group were shorter than those in control group (P<0.05), and there was no significant difference in intermittent forced ventilation time and survival rate between the two groups (P>0.05). The PaO2 and pH value in observation group at 24h of embarkation were higher than those in control group while the PaCO2, FiO2 and OI were lower than those in control group (P<0.05). There were no significant differences in the incidence rate of complications (pneumothorax, pulmonary hemorrhage, bronchopulmonary dysplasia, pneumonia) between the two groups (P>0.05). Conclusions: The combined treatment of pulmonary surfactant and non-invasive high frequency oscillatory ventilation in children with NRDS can significantly improve the curative effect, shorten the time of going on the machine and hospitalization, and effectively improve the arterial blood gas index without significantly increasing complications, which is worthy of clinical application
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2019, Vol. 25 
