|
|
|
| Effects of Nicergoline Combined with Vinpocetine on Hemorheology and Inflammatory Response in Patients with Cerebral Infarction |
| GU Yuming, XU Chunli |
| Shanghai Seventh People's Hospital, Shanghai 200137, China |
|
|
|
|
Abstract Objective: To study the effects of nicergoline combined with vinpocetine on hemorheology and inflammatory response in patients with cerebral infarction. Methods: 116 cases of patients with cerebral infarction in our hospital were selected and randomly divided into control group and observation group, with 58 cases in each group. Both groups were treated with routine therapy, while the control group was treated with vinpocetine; the observation group was treated with nicergoline tablets on the basis of the control group. The observation group was treated with nicergoline tablets on the basis of the control group, and the curative effect was evaluated after 2 weeks of treatment. The hemorheological parameters, inflammatory reaction factors and functional scale scores of the two groups were observed before and after treatment, and adverse drug reactions during treatment were recorded. Results: After treatment, the whole blood ratio, high shear viscosity, low shear viscosity and plasma specific viscosity in the observation group were lower than those in the control group (P<0.05). The levels of TNF-a, IL-6 and hs-CRP in the observation group were significantly lower than those in the control group (P<0.05). The NIHSS and improved Barthel index scores of the observation group were significantly improved compared with those of the control group (P<0.05). And the incidence of adverse drug reactions was similar between the two groups during the treatment period (P>0.05). Conclusions: Nicergoline combined with vinpocetine for patients with cerebral infarction can significantly reduce the hemorheology parameters and serum inflammatory factors levels, improve the patients' coagulation function, and does not increase adverse drug reactions.
|
|
|
|
|
|
[1] 尚广芹,王志宏,姜积军.颈动脉重度狭窄或闭塞导致脑梗死发病机制的研究[J].中风与神经疾病,2016,33(2):128~130.
[2] 冯诗婷,李丽,林云.灯盏花素联合长春西汀治疗急性脑梗死的临床观察[J].中国药房,2017,28(26):3678~3681.
[3] 中华医学会神经病学分会.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246~257.
[4] 陈红英,郭俐宏,王文杰,等.参麦注射液联合长春西汀治疗脑梗死的临床研究[J].中国医药导报,2015,12(18):126~129.
[5] 于明,贾海玉,李国春.急性脑出血患者血液流变学指标变化的相关研究[J].临床神经病学杂志,2017,30(1):1~4.
[6] 孙洪英.肿瘤坏死因子-α基因多态性及其血清水平与脑梗死的相关性[J].中国老年学杂志,2016,36(20):5002~5004.
[7] 陈春利,刘利珍.长春西汀联合疏血通治疗脑梗死疗效观察[J].现代中西医结合杂志,2018,27(16):1772~1775.
[8] 盛守权,乔启家,方茹.尼麦角林联合长春西汀治疗急性脑梗死的临床研究[J].现代药物与临床,2018,33(8):1884~1887. |
|
|
|
2019, Vol. 25 
