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| Effects of Omeprazole combined with Alpha Lipoic Acid on Gastrointestinal Hormones and Oxidative Stress in Type 2 Diabetic Patients with Gastroparesis |
| XU Dan, et al |
| Dandong First Hospital, Liaoning Dandong 118000, China |
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Abstract Objective: To investigate the effects of omeprazole combined with αlipoic acid on gastrointestinal hormones and oxidative stress in patients with type 2 diabetic gastroparesis. Methods: 92 patients with type 2 diabetic gastroparesis who were admitted to the hospital during the period from February to February 2018 were enrolled in the study. They were divided into the control group and the observation group by the simple random grouping method, 46 cases in each group. The control group was treated with αlipoic acid, and the observation group was treated with omeprazole combined with α lipoic acidfor 2 weeks. Blood glucose fluctuation[daily mean amplitude of glycemic excursions (MAGE), standard deviation of blood glucose (SDBG) and the largest amplitude of glycemic excursions (LAGE)], levels of gastrointestinal hormones [gastrin (GAS), motilin (MTL), somatostatin (SS)], oxidative stress indicators [glutathione peroxidase ( GSH-Px), superoxide dismutase (SOD), reactive oxygen species (ROS)] and gastric motility indexes (stomach contraction frequency, gastric emptying time, gastric emptying rate) and adverse reactions were compared between the two groups. Results: The MAGE, SDBG, LAGE, GAS, MTL and ROS levels in the observation group were lower than those in the control group, while SS, GSH-Px and SOD were higher than the control group(P<0.05). The gastric contraction frequency and gastric emptying rate in the observation group were higher than those in the control group, and the gastric emptying time was shorter than that in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (4.35% vs 2.17%) (P>0.05). Conclusion: Omeprazole combined with αlipoic acid can effectively regulate gastrointestinal hormones in patients with type 2 diabetic gastroparesis, relieve oxidative stress and clinical symptoms and promote gastrointestinal function recovery.
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[1] 褚江洪,徐婷,符鸿钧.四磨汤对老年2型糖尿病胃轻瘫患者胃肠激素、胃动力学指标的影响[J].中华中医药学刊,2017,35(11):2962~2965.
[2] 张丹丹,罗晓燕,房辉,等.低频脉冲电联合α-硫辛酸治疗老年人2型糖尿病胃轻瘫的临床疗效[J].中华老年医学杂志,2016,35(6):604~607.
[3] 魏剑芬,陈冬,吴乃君,等.2型糖尿病合并胃轻瘫患者血糖水平的临床观察[J].中国糖尿病杂志,2015,23(3):245~247.
[4] 苟伟.α-硫辛酸对高盐诱发的高血压大鼠头端延髓腹外侧区内氧化应激的抑制作用[J].中国临床药理学杂志,2017,33(14):1328~1331.
[5] 贺东黎,刁云辉.奥美拉唑联合活血化瘀通络方对糖尿病胃轻瘫胃动力障碍疗效及相关指标的影响[J].中国药房,2016,27(12):1605~1607. |
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2019, Vol. 25 
