|
|
|
| Correlations Between Levels of Serum HIF-1α and VEGF with Coronary Artery Calcification in Maintenance Hemodialysis Patients |
| FENG Jingfang, WANG Wenjin, RAO Longhua |
| Xiangyang First People's Hospital Affiliated to Hubei Medical College, Hubei Xiangyang441000, China |
|
|
|
|
Abstract Objective: To detect the levels of serum hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in patients with maintenance hemodialysis (MHD), and to explore the relationships between them with coronary artery calcification (CAC). Methods: 88 patients with MHD in our hospital were selected as MHD group and divided into low-risk group, middle-risk group and high-risk group according to Framingham risk score (FRS); at the same time, 56 healthy persons were selected as the control group. Enzyme linked immunosorbent assay (ELISA) was used to detect the levels of serum HIF-1 and VEGF in two groups, CAC was evaluated by coronary artery calcification score (CACs), the relationships between levels of serum HIF-1, VEGF with CACs in MHD patients were analyzed. Results: Compared with the control group, the smoking rate, hemoglobin (Hb), blood glucose (GLU), C reactive protein (CRP), triglyceride (TG) and high-density lipoprotein cholesterol (HDLC) levels in MHD group were significantly different (P<0.05); the levels of serum HIF-1 and VEGF in group MHD were much higher than those in reference group (P<0.05); the levels of serum HIF-1α, VEGF and CACs score in high-risk group and middle-risk group were significantly higher than those in low-risk group (P<0.05), the levels of serum HIF-1α, VEGF and CACs in high-risk group were significantly higher than those in middle-risk group (P<0.05); the levels of serum HIF-1α and VEGF in MHD patients were positively correlated with CACs (r=0.778, 0.747, P<0.05); multivariate regression analysis showed that HDLC, FRS, HIF-1α, VEGF and CRP were the main influencing factors of CACS. Conclusion: The levels of serum HIF-1α and VEGF are high in patients with MHD, which is related to CACS, and may be involved in the occurrence and development of coronary artery calcification in MHD patients.
|
|
|
|
|
|
[1] 易建,万幼云,徐晓满.两种透析方法治疗终末期糖尿病肾病前后患者血管内皮生长因子和基质金属蛋白酶-9水平变化[J].微循环学杂志,2016,26(2):49~52.
[2] 邓丽玉,林彬,涂胜,等.缺氧诱导因子对急性心肌梗死后心肌细胞及细胞外基质的影响[J].国际心血管病杂志,2016,43(1):43~45.
[3] 徐丽霞,崔燕海,冯仲林,等.维持性血液透析患者冠状动脉钙化及其进展的危险因素[J].肾脏病与透析肾移植杂志,2017,26(5):408~413.
[4] Ruffenach G, Chabot S, Tanguay V F, et al. Role for RUNχ2 in proliferative and calcified vascular lesions in pulmonary arterial hypertension[J]. American Journal of Respiratory & Critical Care Medicine, 2016, 194(10):1273~1285.
[5] 江杰,郑东文,李仪,等.维持性血液透析患者冠状动脉钙化相关危险因素分析[J].中国血液净化,2018,17(6):388~390.
[6] 樊丹平,郭晴晴,李静,等.雷公藤甲素对胶原诱导关节炎大鼠缺氧诱导因子-1α和血管内皮生长因子表达影响[J].辽宁中医药大学学报,2016,18(1):27~29.
[7] Araki N, Misawa S, Shibuya K, et al. POEMS syndrome and calciphylaxis: an unrecognized cause of abnormal small vessel calcification[J]. Orphanet Journal of Rare Diseases, 2016, 11(1):35~41.
[8] Chiang C H, Chu P Y, Hou M F, et al. MiR-182 promotes proliferation and invasion and elevates the HIF-1α-VEGF-A axis in breast cancer cells by targeting FBXW7[J]. American Journal of Cancer Research, 2016, 6(8):1785~1798.
[9] 史聪,李文静,宋培,等.维持性血液透析患者的血清肝细胞生长因子与蛋白质-能量消耗的相关性研究[J].医学研究杂志,2017,46(12):148~153.
[10] 李沙,李树仁,郝清卿.过表达缺氧诱导因子1α心肌干细胞能提高心肌梗死后心功能及移植细胞的存活率[J].中国组织工程研究,2017,21(1):103~109.
[11] 冯珺,白莉,张学良.扁平苔藓皮损中缺氧诱导因子1α、血管内皮生长因子和蛋白激酶B的表达[J].中华皮肤科杂志,2017,50(1):18~21.
[12] 任明芬,魏旭明,张三强,等.急性冠脉综合征与血管内皮生长因子及同型半胱氨酸的相关分析[J].重庆医学,2016,45(8):1046~1048.
[13] 项洁,吴鑫,陆晓,等.兔骨骼肌生理性缺血对缺氧诱导因子-1α的表达和血管内皮生长因子释放的影响[J].中国康复医学杂志,2016,31(10):1055~1059.
[14] 曾海鸥,陈圳炜,罗敏虹,等.血液透析与腹膜透析对非糖尿病终末期肾病患者胰岛素抵抗及冠状动脉钙化的影响[J].中国中西医结合肾病杂志,2016,17(1):26~30. |
|
|
|
2019, Vol. 25 
