不同糖耐量人群甲状腺结节发病率及其相关性研究

doi:10.3969/j.issn.1006-6233.2017.07.014

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Abstract Objective: To compare the prevalence of thyroid nodules among people with different glucose tolerance, and to investigate the relationship between insulin resistance and the incidence of thyroid nodules. Methods: three groups of subjects were collected in this study, 342 patients with type 2 diabetes (T2DM), 145 normal glucose tolerance (NGT), and 180 patients with impaired glucose regulation (IGR), to compare between the three groups of thyroid nodule detection rate, HOMA - IR and Matsuda index. Divided into the nodules group and non-nodules group,and compared the differences between the two groups of gender, age, BMI, HOMA - IR and Matsuda index and correlation. Results: Thyroid nodules prevalence in T2DM group was significantly higher than in IGR and NGT group (P < 0.05);At the same time, the BMI, HOMA IR and TSH levels in T2DM group were higher than the other two groups (P < 0.05); The Matsuda index of T2DM group was lower. The BMI, FPG, HOMA-IR in Thyroid nodule group were higher than those in non- nodules group, P < 0.05; While the Matsuda index is lower than the non-nodule group, P < 0.05. Logistic regression analysis was carried out on the thyroid nodules, and the results showed that thyroid nodule and age, BMI, fasting glucose, HOMA-IR were positively correlated (OR =1.061,1.121,1.114,1.225,95％CI =1.015～1.079,1.057～1.324,1.142～ 1.416,1.112～ 1.428), and negatively correlated with Matsuda index (OR=0.385,95％CI =0.298～0.479). Conclusion: The prevalence of thyroid nodules significantly is higher in the diabetic population, age, gender, fasting glucose, BMI and insulin resistance are independent risk factors for the development of thyroid nodules disease.

Key words： Thyroid nodule Type 2 diabetes Insulin resistance

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2017.07.014 OR http://www.hbyxzzs.cn/EN/Y2017/V23/I7/1101

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