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| Comparison of Efficacy of Two Nucleosides for the Treatment of Hepatitis B-Related Cirrhosis Associated with Hepatogenous Diabetes |
| YANG Jun, et al |
| The First Affiliated Hospital of Chengdu Medical College, Sichuan Chengdu 610500, China |
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Abstract Objective: To compare the efficacy of entecavir and adefovir dipivoxil for the treatment of hepatitis B-related cirrhosis associated with hepatogenous diabetes.Methods: 60 patients with hepatitis B-related cirrhosis associated with hepatogenous diabetes were randomly assigned to the entecavir group or adefovir dipivoxil group each including 30 patients.Entecavir group received entecavir tablets 0.5 mg qd,and adefovir dipivoxil group received adefovir dipivoxil tablets 10 mg qd.Patients in both groups were given diabetic diet,blood glucose control with insulin,and liver protection.The two groups were compared for liver function indicators,Child-Pugh score,HBV DNA load,hepatic fibrosis indicators(PCⅢ,Ⅳ-C,LN,HA),and glucose metabolic indicators(FBG and HbA1c)following 48 weeks of treatment.Results: Compared to adefovir dipivoxil group,there were significant improvements in liver function indicators,Child-Pugh score,HBV DNA load,hepatic fibrosis indicators,and glucose metabolic indicators following treatment in entecavir group(P<0.05).Conclusion: Entecavir could effectively suppress HBV replication,and improve liver function,Child-Pugh score,HBV DNA load,hepatic fibrosis indicators,and glucose metabolic indicators for patients with hepatitis B-related cirrhosis associated with hepatogenous diabetes,with the efficacy superior over adefovir dipivoxil.
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| Fund:四川省卫生厅课题资助,(编号:130384) |
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2017, Vol. 23 
