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| Elderly Patients with General Anesthesia Postoperative Static Note Fluorine Marcie's Influence Cognitive Function and According to Research of Beta Protein Expression |
| WANG Ting, YELIKEN·Yeerdaolaiti, MIRI Guli, et al |
| The Second Affiliated Hospital of Xinjiang Medical University, Xinjian Urumqi 830028, China |
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Abstract Objective: To study the anesthesia in elderly patients with postoperative static note fluorine marcie's influence cognitive function and according to beta protein expression. Methods: Chose between April 2015 and March 2016, orthopaedic surgery treated in our hospital 82 cases of elderly patients. According to random number table method was divided into observation group and the control group each had 41 cases. All patients with general anesthesia processing, then the control group was given 5 ml saline intravenous injection, the observation group were given fluorine marcie, 5 ml intravenous injection. Respectively compared two groups of patients bleeding amount of operating time, wake up of time, extubation time, MMSE score, serum according to beta protein levels before and after operation and the OAA/S score before and after injection. Results: The observation group of waking time, extubation time, respectively (8.7±3.1) min and (13.1±2.4) min, were significantly lower than in the control group (12.9±2.9) min and (15.8±3.7) min, differences were statistically significant (all P < 0.001). After 6 h, 1 d after operation, postoperative MMSE score 3 d observation group were significantly higher than that of control group, differences were statistically significant (all P < 0.001). 6 h after surgery, postoperative serum according to beta level 1 d observation group were significantly lower than the control group, the difference had statistical significance (P < 0.05). 1 min, 2 min, 5 min after injection of OAA/S score of observation group patients were significantly higher than the control group, the differences were statistically significant (all P < 0.05). Conclusion: General anesthesia in elderly patients with postoperative static note fluorine marcie, which can effectively shorten the postoperative patients with waking time, extubation time, at the same time improve patients MMES score, reduce according to beta protein concentration, reducing the occurrence of postoperative cognitive dysfunction in patients.
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| Fund:新疆维吾尔自治区自然科学基金,(编号:2014211C085) |
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[1] Zheng JW, Meng B, Li XY,et al.NF-κB/P65 signaling pathway: a potential therapeutic target in postoperative cognitive dysfunction after sevoflurane anesthesia[J].Eur Rev Med Pharmacol Sci,2017,21(2):394~407.
[2] Grocott HP.Postoperative cognitive dysfunction and low regional cerebral oxygen saturation: is this relationship fragile or fractured altogether[J].Anesth Analg,2017,124(2):697~698.
[3] 刘艳阳,刘佩军,雷德宝,等.奥拉西坦治疗脑梗死患者认知功能障碍的疗效观察[J].卒中与神经疾病,2016,23(3):204~206.
[4] 史成梅,周永德,徐懋,等.小剂量右美托咪啶复合舒芬太尼清醒镇静术在老龄患者多发肠息肉切除术中的应用[J].中华医学杂志,2016,96(43):3474~3478.
[5] Kok WF, Koerts J, Tucha O,et al.Neuronal damage biomarkers in the identification of patients at risk of long-term postoperativecognitive dysfunction after cardiac surgery[J].Anaesthesia,2017,72(3):359~369.
[6] 史学兵,高田,黄庭霞,等.氟马西尼对老年患者术后认知功能的影响[J].解剖与临床,2013,18(2):139~141.
[7] Zhang X, Yao H, Qian Q,et al.Cerebral mast cells participate in postoperative cognitive dysfunction by promoting astrocyte activation[J].Cell Physiol Biochem,2016,40(1):104~116.
[8] 井郁陌,张许霞,齐少霞,等.氟马西尼对术后认知功能影响的研究进展[J].临床麻醉学杂志,2012,28(11):1136~1138. |
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2017, Vol. 23 
