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| The Relationship between Serum Homocysteine and Cognitive Impairment in Patients with Epilepsy |
| LI Jiaojian, DONG Yan, LANG Lang, et al |
| Fuxin Mining Group General Hospital of Liaoning, Liaoning Fuxin 123000, China |
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Abstract Objective: To study the relationship between serum homocysteine (Hcy) and cognitive impairment (MCI) in patients with epilepsy. methods: 120 patients with epilepsy were divided into MCI group (n = 51) and non MCI group according to the impairment of cognitive function (n = 69). The Hcy, S-adenosine methionine (SAM), S-adenosine homocysteine (SAH) levels of were determined, and the Hcy levels and simple mental state assessment scale (MMSE) score were detected. Results: The serum level of Hcy and SAH of patients in MCI group were significantly higher than that in MCI group (P < 0.05); SAM serum level in patients with MCI group was obviously lower than the MCI group (P < 0.05); while serum Hcy levels < 15.0 umoL/L, MMSE score and serum Hcy concentration in patients had no significant correlation (r = 0.19, P > 0.19); When serum Hcy levels acuity 15.0 mu moL/L, MMSE score and serum Hcy concentration had negative correlation (P < 0.05). Conclusion: There are some correlations between serum Hcy and epilepsy patients with MCI. Clinical diagnosis can be carried out accordingly it.
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2017, Vol. 23 
