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| Expression of CD133 β-catenin and hTERT in Gastric Carcinoma and the Clinical Relevance |
| QI Hongxia |
| Jing'an District Central Hospital, Shanghai Jing'an District 200432, China |
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Abstract Objective: To study the expression of CD133, β-catenin and hTERT in gastric carcinoma and the clinical relevance. methods: CD133 β-catenin and hTERT expression in tissue samples of 60 cases of gastric cancer (group A), 60 cases of precancerous lesions (group B) and 40 cases of chronic non-atrophic gastritis (group C) admitted in our hospital from February 2015 to March 2016 were detected by immunohistochemical method and analyzed. Results: The results of immunohistochemistry showed that the positive rates of CD133, β-catenin and hTERT in gastric cancer and precancerous lesions were significantly higher than those in gastritis, the difference was statistically significant (P < 0.05), while the positive rate of gastric cancer was significantly higher than that of cancer precancerous lesion. The expression of A, B group CD133, β-catenin beta and hTERT protein was significantly higher than that in group C, while the A group was significantly higher than that in B group, the differences were statistically significant (P < 0.05); CD133 protein in cancer tissues, β-catenin protein and hTERT protein in higher than that without lymph node metastasis in lymph node metastasis and expression. In the depth of invasion in T3+T4 was higher than that in T1+T2. The difference was statistically significant (P < 0.05). The correlation analysis showed that the expression levels of CD133, β-catenin and hTERT were positively correlated. Conclusion: The expression of CD133,β- catenin and hTERT are closely related to the stomach cancer occurrence, development, invasion and metastasis, which can be used as a clinical reference indexes of early diagnosis and prognosis of gastric cancer.
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2017, Vol. 23 
