右美托咪定对全身麻醉老年患者术后苏醒期躁动及早期认知功能的影响

doi:10.3969/j.issn.1006-6233.2017.01.007

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Abstract Objective: To investigate the effects of dexmedetomidine on the early cognitive function and postoperative agitation in the stage of analepsia in old patients with general anesthesia. methods: A total of 60 eligible patients were collected and randomly divided into observation group and control group, with 30 patients in each group. All the patients were given the same anesthesia, and the observation group used dexmedetomidine additionally, while the control group used the same volume of 0.9% sodium chloride injection. The postoperative cognitive function and agitation in the stage of analepsia after anesthesia were observed. Results: The two groups had insignificantly different operative times, anesthesia times, and times to recovery of spontaneous breathing (P>0.05); but the observation group had significantly shorter analepsia time than those in control group (P<0.05). The incidence of agitation in the stage of analepsia of the observation group was 16.67%, and was significantly lower than that of the control group (53.33%)(P<0.05). On 1d and 7d after the surgeries, the incidences of postoperative cognitive dysfunction of the observation group were 13.33% and 3.33%, respectively, and were significantly lower than those of the control group (30.00% and 16.67%, respectively)(P<0.05). Conclusion: Dexmedetomidine can effectively prevent from postoperative agitation in the stage of analepsia and lighten the effects of the anesthesia on the cognitive function in old patients with general anesthesia.

Key words： Dexmedetomidine Postoperative cognitive dysfunction Agitation in the stage of analepsia General anesthesia

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LIAO Ying,et al. Influences of Dexmedetomidine on the Early Cognitive Function and Postoperative Agitation in the Stage of Analepsia in Elderly Patients with General Anesthesia[J]. HeBei Med, 2017, 23(1): 19-21.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2017.01.007 OR http://www.hbyxzzs.cn/EN/Y2017/V23/I1/19