不同剂量丙泊酚麻醉对接受无痛胃镜检查老年患者认知功能的影响

doi:10.3969/j.issn.1006-6233.2017.04.017

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Abstract Objective: To investigate the influence of different doses of propofol anesthesia in painless gastroscopy in elderly patients with cognitive function Methods: 200 cases of elderly patients admitted in our hospital from January 2013 to January 2015 were selected as study subjects. All the selected cases were randomly divided into group A, group B, group C and the common gastroscopy group, with 50 cases in each group. The patients in painless gastroscopy group A were recived intravenous injection of 1 mg/kg propofol. The patients in group B were recived intravenous injection of 1.5 mg/kg propofol. The patients in group C were injected with 2 mg/kg propofol for gastroscopy. The patients in the ordinary gastroscopy group only received gastroscopy and mucilage mucilage. The mean arterial pressure (MAP), heart rate (HR), respiratory rate (BR) and oxygen saturation (SPO₂) of patients were compared during operation. It was recorded and compared four groups of patients with Montreal cognitive assessment scale (MoCA) and activity of daily living scale (ADL) and mini mental state examination (MMSE) score scale after 1 year. The adverse reactions and the incidence of cognitive dysfunction (POCD) in 1 group were compared and observed between the four groups. Results: At different time points, the changes of MAP, HR and BR in the painless gastroscopy group were decreased in a dose-dependent manner, and the MAP, HR and BR values of painless gastroscopy group C were significantly lower than those of painless gastroscopy group A (P<0.05). On T1, T2, MAP, HR and BR values of each group were significantly lower than that of painless gastroscopy group A (P<0.05). There was no significant difference in SPO₂ values between the groups (P>0.05). After discharge for 1 years, the MMSE, MoCA and ADL scores of painless gastroscopy group C and were statistically significant (P<0.05). The adverse reaction rate of C group was significantly higher than that in painless gastroscopy group A group, B group and common gastroscopy group (P<0.05). The incidence of POCD in painless gastroscopy group was significantly higher than that in A group, B group and C group (P<0.05). Conclusion: Low dose propofol painless gastroscopy has little effect on the cognitive function of elderly patients has clinical value

Key words： Different dose Propofol Painless gastroscopy Elderly patients Cognitive function

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	Articles by authors
	WEN Huahai
	RAN Rui
	TIAN Jiangtao

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WEN Huahai,RAN Rui,TIAN Jiangtao. Effects of Different Doses of Propofol on Cognitive Function in Elderly Patients Undergoing Painless Gastroscopy[J]. 河北医学, 2017, 23(4): 589-593.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2017.04.017 OR http://www.hbyxzzs.cn/EN/Y2017/V23/I4/589

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