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| The Application of Serum Golgi Membrane Protein 73 in Early Diagnosis of Primary Hepatocellular Carcinoma |
| CHEN Fei, ZENG Chuanqin, OU bin |
| The West China Guang'an Hospital, Sichuan University, Sichuan Guang'an 638001, China |
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Abstract Objective: To investigate the clinical value of serum Golgi membrane protein 73 (GP73) in the diagnosis of primary hepatocellular carcinoma (HCC).Methods: 300 people including healthy people, outpatient and inpatient in our hospital from July 2014 to July 2015 were divided respectively into five groups as HCC group, posthepatitic b cirrhosis group, other malignant tumor group, chronic hepatitis B group and healthy control group. The level of Serum GP73 and alpha fetoprotein (AFP) were determined and the ROC curve of its diagnostic HCC was drawn. Result: There was no significant difference in the level of serum GP73 of the patients with different age, tumor size, gender and concentration of serum AFP in the HCC group (P>0.05). The level of serum AFP and GP73 of the patients in the HCC group were significantly higher than that in the other groups(P<0.05), while the level of serum AFP and GP73 of the patients in the chronic hepatitis B, posthepatitic b cirrhosis group and other malignant tumor group were significantly higher than that of the healthy control group(P<0.05). The specificity and sensitivity of GP73 in the diagnosis of HCC were significantly higher than those of AFP, P<0.05. Conclusion: The sensitivity and specificity of serum GP73 in the diagnosis of HCC are better than those of AFP. GP73 can be a serum marker in the early diagnosis of HCC.
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2017, Vol. 23 
