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| Comparative Study of Remifentanil Combined with Propofol versus Propofol Alone in Anesthesia for Hysteroscopic Electrosurgical Procedures |
| TONG Bin, WU Yue, HE Rui, et al |
| The First People's Hospital of Wuhu, Anhui Wuhu 241000, China |
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Abstract Objective: To investigate the application efficacy of two total intravenous anesthesia regimens, remifentanil combined with alfentanil versus propofol combined with alfentanil, during hysteroscopic electrosurgical procedures.Methods: From January 2023 to June 2023, a total of 107 patients undergoing hysteroscopic electrosurgical procedures were included and randomly allocated using a random number table into a control group (n=53) receiving propofol combined with alfentanil anesthesia and an observation group (n=54) receiving remifentanil combined with alfentanil anesthesia. Pain intensity (evaluated using VAS scores), sedation levels (assessed by Ramsay Sedation Scale), vital signs, Modified Aldrete Score (MAS), and adverse reactions were compared between the two groups.Results: Compared with the control group, the observation group showed significantly lower VAS scores at 2 hours and 12 hours postoperatively (P<0.05) and higher Ramsay Sedation Scale scores at 2 hours postoperatively (P<0.05). There were no significant differences in preoperative heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and oxygen saturation (SPO2) between the two groups (P>0.05). However, HR, SBP, DBP, and SPO2 levels were significantly higher in the observation group than in the control group at 5 minutes after the start of surgery and at 2 hours postoperatively (P<0.05). Significant group effects, time effects, and interaction effects were observed for VAS scores, Ramsay Sedation Scale scores, and vital signs (P<0.05). The observation group had higher Modified Observer's Assessment of Alertness/Sedation (MOAA/S) scores at 1, 3, and 5 minutes after surgery compared to the control group (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion: Remifentanil combined with alfentanil provides better pain control and sedation during early postoperative period in patients undergoing hysteroscopic electrosurgical procedures compared to propofol combined with alfentanil. Patients recover faster to a clear consciousness state, and their vital signs are more stable during anesthesia.
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[1] Young S,Miller C E.Hysteroscopic resection for management of early pregnancy loss:a case report and literature review[J].F S Rep,2022,3(2):163-167.
[2] Landoni G,Lomivorotov V V,Nigro N C,et al.Volatile anesthetics versus total intravenous anesthesia for cardiac surgery[J].N Engl Med,2019,380(13):1214-1225.
[3] Walsh C T.Propofol:Milk of Amnesia[J].Cell,2018,175(1):10-13.
[4] Moman R N,Mowery M L,Kelley B.Alfentanil[J].2023.
[5] 贾涛,刘辉,滕金亮.瑞马唑仑的药理特点、安全性及联合用药研究进展[J].中国药房,2023,34(8):1020-1024.
[6] Shafshak T S,Elnemr R.The visual analogue scale versus numerical rating scale in measuring pain severity and predicting disability in low back pain[J].Clin Rheumatol,2021,27(7):282-285.
[7] Rasheed A M,Amirah M F,Abdallah M,et al.Ramsay sedation scale and richmond agitation sedation scale:a cross-sectional study[J].Dimens Crit Care Nurs,2019,38(2):90-95.
[8] Pastis N J,Hill N T,Yarmus L B,et al.Correlation of vital signs and depth of sedation by modified observer's assessment of alertness and sedation (MOAA/S) scale in bronchoscopy[J].Bronchology Interv Pulmonol,2022,29(1):54-61.
[9] 郭鹏飞,姚玲玲,李长生.丙泊酚复合不同浓度七氟醚麻醉对老年术后认知障碍的影响[J].安徽医药,2023,27(6):1130-1135.
[10] 陈艳杰,石福,岳明明,等.瑞马唑仑与丙泊酚用于肝硬化患者无痛胃镜检查的有效量及安全性[J].国际麻醉学与复苏杂志,2023,44(6):616-621.
[11] 陈慧,王佳,张春明.瑞马唑仑注射剂联合瑞芬太尼注射剂用于老年胸腔镜手术患者的临床研究[J].中国临床药理学杂志,2023,39(11):1552-1556.
[12] 王云,张艳珂,桂文虎,等.术前焦虑对术后疼痛的影响研究进展[J].新乡医学院学报,2022,39(10):996-1000. |
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2024, Vol. 30 
