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| Correlation Study of Platelet Parameters NF-κB IL-6 Levels with Disease Severity and Prognosis in Patients with Cirrhosis Complicated by Upper Gastrointestinal Bleeding |
| CAI Xu, XU Shuai, SHANG Shuai |
| No. 902 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Anhui Bengbu 233000, China |
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Abstract Objective: To analyze the correlation between platelet parameters, serum nuclear factor-κB (NF-κB), interleukin-6 (IL-6) levels, and the disease severity and prognosis in patients with cirrhosis complicated by upper gastrointestinal bleeding (UGIB).Methods: A total of 155 patients with cirrhosis complicated by UGIB, treated at our hospital from January 2021 to January 2024, were included in the study. Based on the amount of blood loss before admission, they were divided into a mild group (n=70) and a moderate to severe group (n=85). Additionally, based on the prognosis, they were categorized into a good prognosis group (n=122) and a poor prognosis group (n=33). Platelet parameters [platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT), platelet distribution width (PDW)], serum NF-κB, and IL-6 levels were measured in all patients. Spearman rank correlation analysis was used to evaluate the relationship between these parameters and the severity and prognosis of cirrhosis complicated by UGIB.Results: The PLT, MPV, PCT, PDW, serum NF-κB, and IL-6 levels in the moderate to severe group were significantly higher than those in the mild group (P<0.05). Similarly, these parameters were higher in the poor prognosis group compared to the good prognosis group (P<0.05). Spearman rank correlation analysis indicated a positive correlation between PLT, MPV, PCT, PDW, serum NF-κB, IL-6 levels, and the severity of cirrhosis complicated by UGIB (r=0.226,0.311,0.387,0.311,0.351,0.386; P<0.05).Conclusion: Platelet parameters, NF-κB, and IL-6 levels are closely related to the severity and prognosis of patients with cirrhosis complicated by UGIB. Early detection of these serum indicators can provide a reference for clinical assessment of disease severity and prognosis.
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2024, Vol. 30 
