痰湿体质高脂血症合并抑郁症患者脂代谢指标血清尿酸与尿微量白蛋白水平的相关性分析

doi:10.3969/j.issn.1006-6233.2024.07.027

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Abstract Objective: To analyze the correlation of lipid metabolism, serum uric acid and urinary microalbumin in patients with phlegm-dampness constitution and hyperlipidemia complicated with depression. Methods: The clinical data of 157 patients with hyperlipidemia complicated with depression admitted to our hospital from July 2021 to July 2023 were retrospectively analyzed. In addition, 120 healthy people who came to the hospital for physical examination at the same time were selected as the control group. The general demographic data and laboratory test indicators [total cholesterol (TC), triacylglycerol (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), apolipoprotein A (apoA), apolipoprotein B (apoB), uric acid (UA), microalbumin (mAlb)] were compared between both groups. According to the degree of depression, the patients were divided into mild depression group (n=68), moderate depression group (n=56) and severe depression group (n=33), and the levels of UA and mAlb were compared among the three groups. By means of hyperlipidemia typing, the patients were divided into type Ⅰ group (n=25), type Ⅱ group (n=43), type Ⅲ group (n=48), type Ⅳ group (n=28) and type Ⅴ group (n=13). The levels of UA and mAlb among the five groups were compared. Pearson correlation was used to analyze the correlation between lipid metabolism, UA and mAlb. Results: TC, TG, LDL-C, apoA, apoB, UA, mAlb were significantly higher in patients than in control group (P<0.05) and HDL-C was significantly lower in patients than in control group (P<0.05).The levels of UA and mAlb in different degree of depression patients with hyperlipidemia were statistically significant (P<0.05), and the order was mild depression grouP<moderate depression grouP<severe depression group (P<0.05).Among the 157 patients with hyperlipidemia complicated with depression, 25 were type Ⅰ, 43 type Ⅱ, 48 type Ⅲ, 28 type Ⅳ and 13 type Ⅴ.The levels of UA and mAlb in different types of hyperlipidemia patients with depression were statistically significant (P<0.05), and the order was type Ⅰ grouP<type Ⅱ grouP<type Ⅲ grouP<type Ⅳ grouP<type Ⅴ group (P<0.05). Pearson correlation analysis showed that UA and mAlb were not significantly correlated with TC, TG, LDL-C and apoA (P>0.05), but were negatively correlated with HDL-C (r=-0.431, -0.260, P<0.05) and positively correlated with apoB (r=0.413, 0.428, P<0.05), and UA had positive correlation with mAlb (r=0.522, P<0.05). Conclusion: Serum lipid metabolism indexes and UA and mAlb expression levels are highly expressed in patients with hyperlipidemia complicated with depression, and they are closely related to hyperlipidemia complicated with depression.

Key words： Phlegm-dampness constitution Hyperlipidemia with depression Lipid metabolism index Uric acid Urinary microalbumin

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.07.027 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I7/1202

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