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| Relationship between Serum Sex Hormone Levels and Idiopathic Scoliosis in Adolescent Females |
| HAN Xue, et al |
| Sport Rehabilitation Medical Center, Hebei Institute of Sports Science, Hebei Shijiazhuang 050001, China |
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Abstract Objective: To investigate the relationship between serum sex hormone levels and idiopathic scoliosis (AIS) in adolescent girls, as well as the relationship between sex hormones and the degree of scoliosis and bone mineral density (BMD). The feasibility and credibility of using sex hormones to identify the probability of AIS in adolescent girls were also analyzed. Methods: Thirty-eight adolescent females with AIS (AIS group) treated in our rehabilitation center from February 2018 to December 2023 were selected, and 29 age-matched females without AIS were recruited as the control group. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone, estradiol (E2), Cobb angle, trunk rotation angle, and BMD were measured. The correlation between sex hormone levels and BMD, scoliosis severity in AIS patients, and the value of using sex hormone levels to judge the probability of AIS in adolescent females were analyzed. Results: The serum LH level, Cobb angle, and trunk rotation angle in the AIS group were higher than those in the control group (t=4.532, 42.835, 23.808, P<0.05), while E2 and BMD were lower than those in the control group (t=2.814, 7.082, P<0.05). Serum LH in AIS patients was positively correlated with Cobb angle and trunk rotation angle (P<0.05) and negatively correlated with BMD (P<0.05). E2 levels were negatively correlated with Cobb angle and trunk rotation angle (P<0.05) and positively correlated with BMD (P<0.05). The area under the curve (AUC) for identifying AIS in adolescent females based on E2 and LH was 0.690 and 0.801, respectively. The AUC for identifying AIS in adolescent females based on a combination of E2 and LH was 0.807, which had an identification value (P<0.05), but the difference was not significant compared with the identification value of E2 or LH alone (P>0.05). Conclusion: Sex hormone levels are related to the occurrence of AIS in adolescent females and play an important role in the pathogenesis and progression of the disease. Observation of E2 and LH data alone or in combination can help to identify AIS and assess the severity of the condition.
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[1] 李梦,曲亚斌,孙艺,等.广东省中小学生脊柱侧凸流行特征及影响因素分析[J].中国学校卫生,2022,43(2):292-295.
[2] Wang L,Zhang Y,Zhao S,et al.Estrogen receptors (ESRs) mutations in adolescent idiopathic scoliosis:a cross-sectional study[J].Med Sci Monit,2020(26):921611.
[3] Chmielewska M,Janusz P,Andrusiewicz M,et al.Methylation of estrogen receptor 2 (ESR2) in deep paravertebral muscles and its association with idiopathic scoliosis[J].Sci Rep,2020,10(1):22331.
[4] Peng Y,Wang SR,Qiu GX,et al.Research progress on the etiology and pathogenesis of adolescent idiopathic scoliosis[J].Chin Med (Engl),2020,133(4):483-493.
[5] Liang Z T,Guo C F,Li J,et al.The role of endocrine hormones in the pathogenesis of adolescent idiopathic scoliosis[J].The FASEB Journal,2021,35(9):21839.
[6] Wu RW,Lian WS,Chen YS,et al.Piezoelectric microvibration mitigates estrogen loss-induced osteoporosis and promotes piezo1,microRNA-29a,and wnt3a signaling in osteoblasts[J].Int Mol Sci,2021,22(17):9476.
[7] Schiavi J,Fodera DM,Brennan MA,et al.Estrogen depletion alters osteogenic differentiation and matrix production by osteoblasts in vitro[J].Exp Cell Res,2021,408(1):112814.
[8] Zhang HQ,Wang LJ,Liu SH,et al.Adiponectin regulates bone mass in AIS osteopenia via RANKL/OPG and IL6 pathway[J].Transl Med,2019,17(1):64. |
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2024, Vol. 30 
