糖尿病足感染患者外周血miR-155及miR-132表达水平及其与下肢血管病变程度的关系分析

doi:10.3969/j.issn.1006-6233.2024.07.018

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Abstract Objective: To explore the expression levels of peripheral blood miR-155 and miR-132 in patients with diabetic foot (DF) infection and the relationship with lower extremity vascular lesion degree. Methods: A total of 62 patients with simple type 2 diabetes mellitus (T2DM) in the hospital from June 2020 to June 2023 were selected and included in T2DM group, and 93 patients with T2DM complicated with DF infection during the same period were enrolled as DF infection group. The levels of peripheral blood miR-155 and miR-132 were compared, and the relationship between levels of peripheral blood miR-155 and miR-132 and clinical characteristics in patients with DF infection was analyzed. According to the classification criteria of the Transatlantic Association of Society Consensus (TASC), patients with DF infection were classified into grades A, B, C, and D. The levels of miR-155 and miR-132 in peripheral blood were compared among patients with DF infection and different lower extremity vascular lesion degrees. The Spearman method was used to analyze the correlation between peripheral blood miR-155 and miR-132 and lower extremity vascular lesion degree. Results: The level of miR-155 in DF infection group was higher than that in T2DM group while the level of miR-132 was lower than that in T2DM group (all P<0.05). The course of DF ulcer, wound area, and proportion of Wagner grade IV in the high miR-155 expression group were higher than those in the low expression group, while the course of DF ulcer, wound area, and proportion of Wagner grade IV were lower in high miR-132 expression group than those in low expression group, and the healing rate of DF ulcer after 8 weeks was higher than that in low expression group (all P<0.05). The miR-155 level in patients with DF infection of grade A to D was increased in turn while the miR-132 level was decreased in turn (all P<0.05). Spearman analysis showed that the expression level of miR-155 was positively correlated with lower extremity vascular lesion degree, while the expression level of miR-132 was negatively correlated with lower extremity vascular degree (all P<0.05). Conclusion: The high expression of miR-155 in the peripheral blood of patients with DF infection is positively correlated with degree of lower extremity vascular lesion, and the low expression of miR-132 is negatively correlated with the degree of lower extremity vascular lesion.

Key words： Diabetic foot Infection Lower extremity vascular lesion miR-155 miR-132 Type 2 diabetes mellitus

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.07.018 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I7/1156

[1] Alsabek MB,Abdul Aziz AR.Diabetic foot ulcer,the effect of resource-poor environments on healing time and direct cost:a cohort study during Syrian crisis[J].Int Wound,2022,19(3):531-537.
[2] Heyward J,Mansour O,Olson L,et al.Association between sodium-glucose cotransporter 2 (SGLT2) inhibitors and lower extremity amputation:a systematic review and meta-analysis[J].PLoS One,2020,15(6):234065.
[3] Qin B,Peng Q,Dong H,et al.Non-coding RNAs in diabetic foot ulcer- a focus on infected wounds[J].Diabetes Metab Res Rev,2023,15(1):3740.
[4] 中华医学会糖尿病学分会,中华医学会感染病学分会,中华医学会组织修复与再生分会.中国糖尿病足防治指南(2019版)(Ⅳ)[J].中华糖尿病杂志,2019,11(5):316-327.
[5] Darenskaya MA,Kolesnikova LI,Kolesnikov SI.Oxidative stress:pathogenetic role in diabetes mellitus and its complications and therapeutic approaches to correction[J].Bull Exp Biol Med,2021,171(2):179-189.
[6] 尚俊良,王广宇,石春红,等.血清C反应蛋白、前白蛋白及其比值在2型糖尿病足中医证型之间的表达水平及结局分析[J].世界中西医结合杂志,2023,18(9):1799-1804.
[7] 郑海龙,曹晓琳,吴海丽,等.糖尿病足患者感染特征与下肢血管病变及免疫功能和C反应蛋白的效果研究[J].中华保健医学杂志,2021,23(5):508-509.
[8] Ge L,Wang K,Lin H,et al.Engineered exosomes derived from miR-132-overexpresssing adipose stem cells promoted diabetic wound healing and skin reconstruction[J].Front Bioeng Biotechnol,2023,11(1):1129538.
[9] Zhang W,Wang L,Wang R,et al.A blockade of microRNA-155 signal pathway has a beneficial effect on neural injury after intracerebral haemorrhage via reduction in neuroinflammation and oxidative stress[J].Arch Physiol Biochem,2022,128(5):1235-1241.
[10] Chen X,Ou Y,Wang Z,et al.Association between systemic immune-inflammation index and risk of lower extremity deep venous thrombosis in hospitalized patients:a 10-year retrospective analysis[J].Front Cardiovasc Med,2023,10(1):1211294.